UA138610U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes clinical examination, radiography. Additionally, in the patient's serum determine the polymorphism of the gene for methylenetetrahydrofolate reductase (MTHFR C677T), the content of thrombomodulin, folic acid, glycosaminoglycans (GAG), C-reactive protein (SRP), interleukin 6 (IL-6). With a homozygous carrier of 677-TT and levels of thrombomodulin> 5 ng / ml, folic acid <6 ng / ml, GAG> 28 μmol / l, PSA> 6 mg / l, IL-6> 10 ng / l predict the development of osteoarthritis.

Description

The proposed useful model The method of predicting the development of osteoarthritis belongs to medicine, in particular to orthopedics and rheumatology. The method is intended and can be used in diagnosing the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (Okorokov

A.N. Diagnosis of diseases of internal organs. - M., 2001. - T. 2. - b. 186-196). The disadvantage of these methods is the lack of an opportunity to predict the dynamics of the process in the early subclinical stages, to prevent its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, according to a useful model, the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEV C677T), the content of thrombomodulin, folic acid, glycosaminoglycans (GAG), C-reactive protein (CRP), is determined in the patient's blood serum. interleukin 6 (IL-b6) and with homozygous carrier 677-TT, the content of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, GAG "28 μmol/l, SRP "6 mg/l, IL-6 "10 ng/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, an X-ray is taken, and the MTNEV C677T gene polymorphism is determined. The content of thrombomodulin, folic acid, GAG, SRP, IL-6 is determined by immunoenzymatic method. With homozygous carrier 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, GAG "28 μmol/l, SRP "b mg/l, IL-6 510 ng/l predict the development of osteoarthritis.

A specific example of using the method

Patient P., 67 years old, was admitted to the clinic due to pain in the right hip joint. Examined, x-ray taken. No signs of osteoarthritis were found. Polymorphism of MTNEV C677T gene was determined in blood serum. The content of thrombomodulin, folic acid, GAG, SRP, IL-6 was determined by immunoenzymatic method. Homozygous carrier 677-TT was established. Levels of thrombomodulin - 14 ng/ml, folic acid - 3.2 ng/ml, GAG - 43 μmol/l, SRP - 18 mg/l, IL-6-25 ng/l. The development of osteoarthritis was diagnosed. After 13 months on

X-rays revealed the phenomena of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

Claims (1)

USEFUL MODEL FORMULA The method of predicting the development of osteoarthritis, which includes a clinical examination, X-ray photography, which is distinguished by the fact that the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEV C677T), the content of thrombomodulin, folic acid, glycosaminoglycans (GAG), C-reactive protein (CRP), is additionally determined in the patient's blood serum. interleukin b (IL-6) and with homozygous carrier 677-1T and levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, GAG 228 μmol/l, SRP "6 mg/l, IL-6 210 ng/ predict the development of osteoarthritis.