UA137863U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes a clinical examination, radiography. Additionally, the patient's serum determines the polymorphism of methylenetetrahydrofolate reductase (MTHFR C677T), nitric oxide synthase (eNOS T786C), thrombomodulin, folic acid, oxyproline, interleukin 6 (IL-6), go. With a homozygous carrier of 677-TT, 786-CC and levels of thrombomodulin> 5 ng / ml, folic acid <6 ng / ml, oxyproline> 15 μmol / l, IL-6> 10 ng / l, homocysteine> 20 μmol / l predict development of osteoarthritis.

Description

The proposed useful model belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in the diagnosis of the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies

I.N. Okorokov Diagnosis of diseases of internal organs. - M., 2001. - Vol. 2. - P. 186-196).

The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that in the method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, according to a useful model, polymorphisms of the genes methylenetetrahydrofolate reductase (MTNEV C677T), nitric oxide synthase (6ЕМО5 T786С), thrombomodulin content are additionally determined in the patient's blood serum. folic acid, oxyprolin, interleukin 6 (IL-6), homocysteine and with homozygous carrier 677-TT, 786-SS, and levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, oxyprolin "15 μmol/l, IL-b 510 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis.

The method is used as follows.

During hospitalization, the patient is examined, x-rays are taken, the polymorphism of MTNEV C677T, eMmo5 1786C genes, the content of thrombomodulin, folic acid, oxyproline, IL-6, and homocysteine are determined by the immunoenzymatic method. With homozygous carrier 677-TT, 786-SS, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, oxyproline 215 μmol/l, IL-6 "10 ng/l, homocysteine 220 μmol/l predict the development of osteoarthritis .

A specific example of using the method.

Patient T., 68 years old, was hospitalized in the clinic due to pain syndrome of the left hip joint. Examined, X-ray taken. No signs of osteoarthritis were found.

The polymorphism of MTNEV C677y and emMmo5 7860 genes was determined in blood serum.

The content of thrombomodulin, folic acid, oxyproline, IL-

From 6, homocysteine. A homozygous carrier of 677-TT and 786-SS was established, the levels of thrombomodulin - 11 ng/ml, folic acid - 2.5 ng/ml, oxyproline - 23 μmol/l, IL-6-18 ng/l, homocysteine -

30 μmol/l. The development of osteoarthritis was diagnosed. After 12 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

Claims (1)

USEFUL MODEL FORMULA A method of predicting the development of osteoarthritis, which includes conducting a clinical examination, 40 x-ray, which is distinguished by the fact that in the patient's blood serum polymorphisms of the genes methylenetetrahydrofolate reductase (MINEV Сб677Т), nitric oxide synthase (emo5 1Т786С), the content of thrombomodulin, folic acid, oxyproline, interleukin b (IL-b), homocysteine, and homozygous carrier 677-TT, 786-SS, and levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, oxyproline 215 μmol/l, IL-6 "10 ng/l, homocysteine 220 μmol/l 45 predict the development of osteoarthritis.