UA137834U - METHOD FOR PREDICTING THE DEVELOPMENT OF OSTEOARTHRITIS - Google Patents

Abstract

The method of predicting the development of osteoarthritis includes clinical examination and radiography. Additionally, in the patient's serum determine the polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR C677T), the content of thrombomodulin, folic acid, C-terminal propeptide type I collagen (SISR), C-reactive protein (SRP), and interleukin 6 677-TT and levels of thrombomodulin> 5 ng / ml, folic acid <6 ng / ml, SISR <102 ng / ml, PSA> 6 mg / l, IL-6> 10 ng / l predict the development of osteoarthritis.

Description

A useful model belongs to medicine, in particular to orthopedics and rheumatology. It is prescribed and can be used in the diagnosis of the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (A.N.

Okorokov Diagnosis of diseases of internal organs. M., 2001. - vol. 2. - pp. 186-196). The disadvantage of these methods is the inability to predict the dynamics of the process in the early subclinical stages, the inability to prevent its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to clinical examination and radiography, according to a useful model, the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEK C677T), the content of thrombomodulin, folic acid, C-terminal propeptide of type I collagen (SICP), C- reactive protein (SRP), interleukin 6 (IL-b) and with homozygous carrier 677-TT, thrombomodulin content "5 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l , IL-6 »10 ng/l predict the development of osteoarthritis.

Application of the method. During hospitalization, the patient is examined, X-rays are taken, and the MTNEK S677T gene polymorphism is determined. The content of thrombomodulin, folic acid, SISR, SRP, IL-6 is determined by immunoenzymatic method. With homozygous carrier 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SICR "102 ng/ml, SRP "6 mg/l, IL-6 510 ng/l predict the development of osteoarthritis.

A specific example of using the method.

Patient O., 63 years old, was hospitalized in the clinic due to pain syndrome in the right knee joint. Examined, x-ray taken. No signs of osteoarthritis were found. The MTNEK C677T gene polymorphism was determined in blood serum. The content of thrombomodulin, folic acid, SISR, SRP, IL-6 was determined by immunoenzymatic method. Homozygous carrier 677-TT was established. Levels of thrombomodulin - 14 ng/ml, folic acid - 3.8 ng/ml, SICP - 78 ng/ml,

SRP - 18 mg/l, IL-b6 - 23 ng/l. The development of osteoarthritis was diagnosed. After 12 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosing the development of osteoarthritis at an early stage.

Claims (1)

USEFUL MODEL FORMULA The method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEK C677T), the content of thrombomodulin, folic acid, C-terminal propeptide of type I collagen (SICP), C- reactive protein (SRP), interleukin 6 (IL-b) and with homozygous carrier 677-TT and levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, SISR "102 ng/ml, SRP "6 mg/l , IL-6 »10 ng/l predict the development of osteoarthritis.