UA130796U - METHOD OF FORECASTING OSTEOARTHrosis DEVELOPMENT - Google Patents

Abstract

A method for predicting the development of osteoarthritis involves clinical examination, radiography, determination of serum polymorphism of the eNOS T786C gene and content of pyridinoline, homocysteine, IL-6, PSA. With homozygous carrier 786-SS and levels of pyridinoline> 8 ng / ml, homocysteine> 20 μmol / l, IL-6> 10 ng / l, PSA> 6 mg / l predict the development of osteoarthritis.

Description

The proposed useful model for predicting the development of osteoarthritis belongs to medicine, in particular to orthopedics and rheumatology. The method is intended and can be used in diagnosing the development of osteoarthritis in the early stages.

Methods of predicting the development of osteoarthritis are known. These include x-rays, studies of biopsies of the synovial membrane, synovial fluid, and cartilage biopsies (A.N.

Okorokov Diagnosis of diseases of internal organs. M., 2001. - vol. 2. - pp. 186-196). The disadvantage of these methods is the lack of the possibility of predicting the dynamics of the process in the early subclinical stages, preventing its development and possible complications due to the internal characteristics of the body.

The basis of a useful model is the task of developing a method that would allow predicting the development of osteoarthritis in the early stages.

The task is solved by the fact that, in addition to conducting a clinical examination and radiography, the polymorphism of the nitric oxide synthase gene (EeMO5 T7860C), the content of pyridinoline, homocysteine, interleukin b (IL-6), C-reactive protein (CRP) and with homozygous carrier 786-SS, levels of pyridinoline 28 ng/ml, homocysteine 220 μmol/l, IL-6 210 ng/l, SRP »6 mg/l predict the development of osteoarthritis.

Application of the method.

During hospitalization, the patient is examined, x-rays are taken, the polymorphism of the emo T786C gene is determined, the content of pyridinoline, homocysteine, IL-6, SRP is determined by the immunoenzymatic method.

With homozygous carrier 786-SS and levels of pyridinoline »8 ng/ml, homocysteine 220 μmol/l, IL-6 210 ng/l, SRP »6b mg/l predict the development of osteoarthritis.

A specific example of using the method.

Patient V., 56 years old, was hospitalized in the clinic due to pain syndrome in the left knee joint. X-rays were examined and carried out. No signs of osteoarthritis were found. The eMMO5 T786C gene polymorphism and pyridinoline, homocysteine, IL-6, SRP content were determined in the blood serum using the immunoenzymatic method. A homozygous carrier of 786-SS was established, the levels of pyridinoline - 16 ng/ml, homocysteine - 29 μmol/l, IL-6-21 ng/l, SRP -15 mg/l. The development of osteoarthritis was diagnosed. After 13 months, X-rays revealed signs of osteoarthritis.

Thus, the proposed method is informative and allows diagnosis

From the development of osteoarthritis in the early stages.

Claims (1)

USEFUL MODEL FORMULA A method of predicting the development of osteoarthritis, which includes a clinical examination, radiography, which is distinguished by the fact that the emMo5 1786C gene polymorphism and the content of pyridinoline, homocysteine, IL-6, SRP are determined in the blood serum, and in the case of homozygous carrier 786-SS and its levels pyridinoline »8 ng/ml, homocysteine 220 μmol/l, IL-6 »10 ng/l, SRP 26 mg/l predict the development of osteoarthritis.