UA125906U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of MTHFR S677T gene polymorphism in serum, endothelin content, folic acid, SOMP, SRP, homocytosis. With homozygous carrier 677-TT, endothelin levels> 10 ng / ml, folic acid <6 ng / ml, COMP> 595 ng / ml, SRP> 6 mg / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography of Ts|A.N. Okorokov

Diagnosis of diseases of internal organs. - M.: Med. lit., 2003. - Vol. 6. - P. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow early diagnosis of atherosclerosis.

The task is solved by the fact that, along with the study of low and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the methylenetetrahydrofolate reductase gene (MITNEV Сб677Т), the content of endothelin, folic acid, cartilage oligomeric matrix protein (COMP), C-reactive protein ( SRP), homocysteine. At a homozygous carrier of 677-TT, levels of endothelin 210 ng/ml, folic acid "b ng/ml, SOMR "595 ng/ml, SRP "6 mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the MTNEV C677T gene polymorphism is determined. The content of endothelin, folic acid, SOMP, SRP, homocysteine is determined by immunoenzymatic method. With homozygous carrier 677-177, levels of endothelin 210 ng/ml, folic acid "6 ng/ml, SOMR "595 ng/ml, SRP "6 mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient M., 58 years old, was hospitalized with a diagnosis of rheumatoid arthritis.

Examined Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. No signs of atherosclerosis were detected. Polymorphism of MTNEVK C677T gene was determined in blood serum. The content of endothelin, folic acid, SOMP, SRP, homocysteine was determined by immunoenzymatic method. Homozygous carrier 677-1T was established. Levels of endothelin - 18 ng/ml, folic acid - 3.6 ng/ml, COMP - 695 ng/ml, SRP - 13 mg/l, homocysteine - 29 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic confirmation of the diagnosis was obtained only after 12.5 months.

Thus, the proposed method of diagnosing the development of atherosclerosis allows to determine it in the early stages.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 low- and high-density lipoprotein cholesterol, arteriography, determination of the MTNEV Sb677T gene polymorphism in blood serum, the content of endothelin, folic acid, SOMP, SRP, homocysteine, which is distinguished by the fact that with homozygous carrier 677-YIT, endothelin levels are 210 ng/ml, folic acid "6 ng/ml, SMP "595 ng/ml, SRP 26 mg/l, homocysteine "20 μmol/l diagnose the development of atherosclerosis.