UA123758C2 - APPLICATION OF ALS INHIBITORY HERBICIDES TO CONTROL UNWANTED VEGETATION IN AREAS GROWING TOLERANT TO INHIBITIVE INHIBITORS - Google Patents

Abstract

FIELD: medicine. moreover, beet plants, optimally sugar beets, include a mutation in codon 1705-1707 of the endogenous ALS gene encoding an ALS protein containing an amino acid other than tryptophan at position 569, optimally tryptophan is replaced by leucine.

Description

of the AG 5 gene, which encodes the AI 5 protein, which contains an amino acid other than tryptophan at position 569, in the optimal version, tryptophan is replaced by leucine.

This invention belongs to the field of protection of cultivated plants through the use of inhibiting AI 5 (acetolactate synthase, also known as ANA5 (acetohydroxy acid synthase; ЕС 2.2.1.6; formerly - ЕС 4.1.3.18)) herbicides against unwanted vegetation in areas where beet plants are grown (Veia mpiYidagi5 ), in the optimal version - sugar beet, which are tolerant to AI 5-inhibiting herbicides, due to the inclusion of a mutation in codon 1705-1707 of the endogenous AI 5 gene and encoding, thus, the AI 5 polypeptide, which has an amino acid different from natural tryptophan in the position 569.

Cultural forms of common beet (as defined in the publication of Roga-I Ioua (2005) botsshgsev oi depeiis magaiyop, Sepyv Veia. Ip: Viapsagdi E, Satrbeyi s, 5Kagasie M, Oe Viaddi M (edv)

Sepeiys5 apa Vgeedipd oi Zydag Veei. Zsiepse RybiizNeg5, Epiviy (MN), OA, yr. 25-33) are important agricultural crops in areas with a temperate and subtropical climate. For example, about 2,095% of the world's sugar production is based on sugar beet. As seedlings and young beet plants during the first 6-8 weeks of their life are sensitive to stiff competition caused by fast-growing weeds that suppress young crop plants, reliable weed control measures are an urgent need in crop production areas.

For more than 40 years, herbicides have been considered the optimal means of weed control in sugar beet cultivation areas (Veia mtsidagi5, subspecies miiYidagi5, variety Apivzita). Products used for this purpose, such as phenmedipham, desmedipham, etofumesatta metamitron, allow suppressing weeds in sugar beet fields without harming the crop. Despite this, under unfavorable environmental conditions, the effectiveness of these products is still far from the maximum, especially in cases where such weeds as

Speporodiitis airitis, Atagapipyv heigoyehiv and/or RaIPoria sopmoymshi5, develop over a long period of time.

The AI 5/ANA5 enzyme is present in bacteria, fungi, and plants, and protein isolates have been obtained from various organisms, and their corresponding amino acid/nucleic acid sequences, as well as their biochemical characteristics, have been determined/characterized (see Shtbragaeg, N.E. ., Appi. Nehu. Biospet. (1978), 47, 533-606; SNitap, O.M.

Viospit. Viorpuv. Asia (1998), 1385, 401-419; Oiddiebu, V.S, and Rapo, 5.5., U. Viospet. Mo). Vio).

Zo (2000), 33, 1-36; YuOpadiebu, V.S. (Bigisiige apa Rgorepievz oi Aseyupuagohuasia Zupipaze ip Tiatipe:

Sagauis Mespapivtv ip Mogtai apa Oiveaze biaievz, My 11, Magsie! OekKeg, Mem Moik, 2004, 251-274).

The use of herbicide compounds that belong to the class of inhibitors A! 5, such as (a) sulfonylurea herbicides (Veuyeg EM ei ai. (1988), ZyMopuishgeav ip Negbrisidev: Spetivigu,

Juedgadayop, apa Mode oi Asiop; Magsie! OekKeg, Mem MOZH, 1988, 117-189), (B) sulfonylaminocarbonyltriazolinone herbicides (Ropigep, V., RPapl.-Masngisniep Vaueg, 2002, 55, 37-52), (c) imidazolinone herbicides (ZPPapeg, O.I. ., eyi ai., Riapi Rnuzio!., 1984, 76, 545-546;

Zpapeg, 0.I., and O'Soppog, 5.1. (Edv.) Tne Itidagoiipope Negbriside5, SAS Rgezv, Vosa Rayo, NI, 1991), (a) triazolpyrimidine herbicides (KiezspiskK, MU. A. eyi ai., Adgis. Rosa Speth., 1992, 40, 1083-1085) , and (are) pyrimidinyl (thio)benzoate herbicides (Zpitii, T.9., Reziis. Zsi., 1997, 22, 245-256;

ZPiti?y, T. eyi ai., Aseyuiasiaie Zupieenaze Ippiriyug5 ip Netiside Siazze5 ip Oemeiortepi, Vodeg",

R. MMaKabrauzni. K., Nigai, K., (Edv»j.), brgipdeg Mepad, Vepip, 2002, 1-41), for combating unwanted vegetation on areas of cultivation of various crops is well known in the field of agriculture.

A wide range of A B/ANA5 inhibitory herbicides allows farmers to control a variety of weeds regardless of their growth stage, but these highly effective herbicides cannot be used on common beet, in particular sugar beet, because common beet, in particular, traditional sugar beet plants / commercial varieties of sugar beet, are very susceptible / vulnerable to these AI5-inhibiting herbicides. Despite this, such AI5-inhibiting herbicides demonstrate excellent herbicidal activity against broad-leaved and herbaceous weed species. The first herbicides based on A inhibitors! 5 were developed for their use in agriculture as early as 30 years ago. Currently, the active ingredients of this class demonstrate high effectiveness in the fight against weeds and are widely used to protect corn and cereals, as well as dicot crops, but not for common beets, in particular, sugar beets.

Currently, there is only one sulfonylurea herbicide product in industrial production, that is, Oerike (component (A) 50 95 triflusulfuron-methyl and component (B) a specific compound for formulation, that is, a specific adjuvant), which can be used on areas under sugar beet in the regime of post-emergence application, but it must be applied at a very early stage of development of weed leaves, and also reveals significant gaps in the processing of serious weeds that grow in areas under sugar beet. This sulfonylurea is not tolerated by sugar beet plants, but breaks down in them.

Another, more reliable and flexible way to obtain plants of ordinary beet, in the optimal version - sugar beet, which would withstand treatment with an AI 5-inhibiting herbicide, is to create mutants that have sufficient tolerance to the agronomically effective / necessary amount of AI 5-inhibiting herbicides in order to suppress serious unwanted vegetation on the areas where beet plants are grown, and in the optimal version - sugar beet.

Since the introduction of AI 5-inhibiting herbicides in agriculture, it has been observed that susceptible plant species, including natural weeds, sometimes develop spontaneous tolerance to this class of herbicides. Individual substitutions of pairs of nucleotides in certain sites of the gene

AI5 usually lead to more or less resistant varieties of the AI5 enzyme that show different levels of inhibition by AI5-inhibiting herbicides.

Thus, plants harboring AI 5 mutant alleles show varying levels of tolerance to AI5-inhibiting herbicides, depending on the chemical structure of the A5-inhibiting herbicide and the location of the point mutation(s) in the AG5 gene and the AI5 protein thus encoded. .

Several AI 5 mutants (natural in weeds as well as artificially induced in cultivated plants through mutations or transgenic technologies) that confer tolerance to one or more of the chemicals defined under the above classes/groups of AI 5-inhibiting herbicides are known in various parts of the enzyme (i.e., in the α-, β-, and γ-domains of AI5) and are known and found in various organisms, including plants (US Patent No. 5,378,82; Yuiddieru, V.O. ei ai., (2008), Riapi Rnuzio!. apa Viospet., pp. 309-324; Biutsap, T. Yei Ai. (2005), Revi Mapadetepi

Zsi., 61, pp. 246-257; dip, 5. (2004) Viospet 9., pp. 53-61; KoiKtap, 9U.M. (2004), Tneog. Arri.

Sepei., 109, 1147-1159; Yuidaiebu, V.S. Hey! (2003), Yeshg. U. Viospet., 270, pp. 1295-2904; Rapo, 5.5., you a). (2003), 9. Vioi. Snet., pp. 7639-7644); Madam, M. Yei a!., (1986), Rhos. Mai). Asad 5si., 83, pp. 4418-4422), supplement of S. ei a). (2003), Riapi Rnuzioi!., 131, pp. 139-146); Tgapei, R.U., apa UUtidni,

AND. (2002), Meey Zsiepse, 50, pp. 700-712); Spapo, A.K., and Oiddieru, V... (1998), Viosnet »., 333, pp. 765-777).

Cultivated plants that provide mutant АЙ5 alleles show different levels of tolerance to АЙ5-inhibiting herbicides, depending on the chemical structure of the inhibiting А 5

From the herbicide and the site of the point mutation in the AI 5 gene.

For example, in the publication of Nayogi Yeyi AI. (1995), My. Seep. (zepei. 246:419-425, describes a unidirectional mutation in codon Ttr 557 of the Vgazbis parib5 cell line (according to the sequence numbering of Agaridorvzi5 INaiyapa, which is used in the literature, for the purpose of comparing all A5/ANA5 mutants, it corresponds to position "574") - which is equal to position 569 of the beet AI 5 polypeptide sequence.These authors observed resistance to several members of subclasses of inhibitory A!5 herbicides, such as sulfonylureas, imidazolinones, and triazolepyrimidines.

The patent EP-A-0360750 describes the production of plants tolerant to the AI 5 inhibitory herbicide by creating an increased number of attacked A! 5 inside the plant. Such plants show increased tolerance to some sulfonylureas, such as chlorsulfuron, sulfometuron-methyl, and triasulfuron.

Patent 5 5,198,599 describes sulfonylurea and imidazolinone tolerant plants that have been bred and show tolerance to chlorsulfuron, bensulfuron, chlorimuron, thifensulfuron and sulfometuron.

In addition, patents 05 5,013,659, 05 5,141,870 and 05 5,378,824 describe the production of transgenic sugar beet plants by incorporating the AI 5 gene of modified yeast into such sugar beet plants

In addition, in the publication ZaypaegveiaI. (Stor Osiepsee, 1992, 32, 1317-1320) describe sulfonylurea-tolerant sugar beet plants obtained through somaclonal selection of cells, but these authors did not present any biological data regarding the level of tolerance of such plants to treatment with an AI5-inhibiting herbicide and did not demonstrate genetically resistant mutants obtained from cultures in which such mutations were induced.

In the publication of the hotsdaaga ei ai. (1990), U. Sei! Viospet., Zirri. 14E, 310, describes the selection of mutants A 5 in the culture of tetraploid cells of sugar beet. Two different A 5 genes (AI 5 I and AI 5 II) were isolated, which differed only in amino acid position 37. Mutant 1 contained in its

AI 5 I gene 2 mutations, and 2 contained Z mutation in its AI 5 II gene. After isolation of mutations to determine the specific mutation that should provide resistance to the AI 5 inhibitor, it was found 60 that AI 5 synthesized from recombinant E. soya was resistant to herbicides if it contained a point mutation in codon Tgr 574 (according to sequence numbering Agaridorov INaiapa, which is used in the literature, for the purpose of comparing all AI mutants 5) - which is equal to position 569 of the amino acid sequence A! From beets, which leads to the replacement of the amino acid "Ttr" with the amino acid "Gay". Authors of b5iotsdaaga eyi a. did not demonstrate on sugar beet that a mutation at position 569 of any of the AI 5 genes of sugar beet is sufficient to achieve an agronomically acceptable level of tolerance to AI 5 inhibitory herbicides. In addition, Ijutsdaaga ei ai did not regenerate or consider sugar beet plants that include mutations, including the Tgr -- I ei mutation at position 569 AI 5 of sugar beet.

On the basis of this information bioidaaga eyi am. constructed plant transformation vectors that contained various AII 5 genes for use in plant transformation. However, until now no data have been reported by these or other authors during the following more than 20 years, in particular, regarding the effect of the application of AI 5-inhibiting herbicides to plants and/or agricultural areas, with the inclusion of this mutation in common beet plants, or subjected to genetic engineering, or mutated.

In addition, beet mutants have been described that provide a point mutation in codon Aa 122, which leads to a certain tolerance to imidazolinones of the subclass of AI5-inhibiting herbicides (document MO 98/02526), which is still insufficient for weed control in agricultural applications. application. There was no information on cross-tolerance to other classes of AI-inhibiting 5 herbicides when using this mutant. In addition, beet plants harboring a second point mutation in codon Rgo 197 demonstrated moderate tolerance to AI 5-inhibiting herbicides belonging to the sulfonylurea herbicide subclass. Double mutants consisting of these two have also been described (MO document 98/02527). However, none of these mutants have been used to market beet varieties because the level of tolerance to inhibitory A! 5 herbicides in these mutants was not high enough for agronomic use.

Document M/O 2008/124495 describes double and triple A! 5 mutants. According to document UMO 2009/046334, specific mutations in the AI 5 gene were provided. However, mutants of common beet that contain such mutations according to document MO 2009/046334 and also demonstrate sufficient tolerance to any type of AI 5 inhibitors are suitable for agronomic use. herbicides of different classes of AI-inhibiting 5 herbicides, so far not been obtained / described.

None of these sugar beet mutants show reliable tolerance to different classes of AI 5-inhibiting herbicides, and even worse: they do not show an agronomically acceptable level of tolerance to any type of AI 5-inhibiting herbicide.

Since these are compounds known to act as AI 5 inhibitory herbicides, they can be divided into several classes.

Compounds from the group of (sulfon)amides are already known as herbicidally active compounds for controlling unwanted vegetation; see, for example, the docs

ER 239414, 05 4288244, CE 3303388, 05 5457085, 005 3120434, 005 3480671, ER 206251, ER 205271, 25 2556664, 05 3534098, 05

869169, ER 447004, CE 1039779, but 176582, 05 3442945, CE 2305495, CE 2648008, CE 2328340, OE 1014380, but 53483, 05 48029 , OE 1031571, 05 3175897, OR 1098331, 005 2913327, Mo 8300329, ur 80127302, CE 1300947, OE 2135768, 05 3175887, 05 3836524 4394506, 05 4127405, 5 4479821, 005 5009699, ER 136061, ER 324569, ER 184385, MO 2002030921, Mo 092155576, MO 095299999 4789393, ER 971902, 05 5209771, ER 84020, ER 120814, ER 87780, MO 08804297, ER 5828924,

MO 2002036595, 05 5476,936, MO 2009/053058 and literary sources given in the above publications.

Compounds from the group of imidazolinones are already known as herbicidally active compounds for controlling unwanted vegetation; see, for example, publications

Rgos. Boche. Mrs. boss. 1992. 45, 341, Rhos. Botius Meeai 5si. wasps Apps. Mia Failure, 1983, 29, Mei Zsi. boss. Apps. Mia Failure, 1983, 90-91, MU/eed si. boss. Med., 1984, 18, Modet

Adhospetisai!v5, 2004, 14-15.

Compounds from the group of pyrimidinyl (thio)benzoates are already known as herbicidally active compounds for controlling unwanted vegetation; see, for example, documents 5 4906285, EP 658549, 005 5118339, MO 91/05781, 54932999 and EP 315889.

Compounds from the group of sulfonanilides are already known as herbicidally active compounds to control 60 unwanted vegetation; see, for example, the docs

MO 93/09099, MO 2006/008159 and MO 2005/096818.

All publications and patents cited herein are incorporated by reference in their entirety. If material incorporated by reference conflicts with or is inconsistent with this description, that description takes precedence over any such material.

Considering that, for example, about 20 95 percent of the world's sugar is produced from sugar beets, there is a great need for a weed control system that would allow effective control of highly active and serious weeds. Thus, it is highly desirable to use one or more AI 5-inhibiting herbicides to combat unwanted vegetation on common beet growing areas, and ideally, sugar beet plants that are tolerant to such AI 5-inhibiting herbicides.

This problem is solved by the present invention.

The present invention relates to the use of one or more AI 5 inhibitory herbicides, which belong to one of the different classes of AI 5 inhibitory herbicides, to combat unwanted vegetation on areas where beet plants are grown, in the optimal version - sugar beet, where beet plants are optimally in the variant - sugar beet plants, include a mutation in codon 1705-1707 of the endogenous acetolactate synthase gene (A 5), which encodes the AI 5 protein, which includes an amino acid different from tryptophan at position 569, and in the optimal version, the tryptophan of the wild-type AI 5 protein is substituted by leucine at position 569.

A seed of a sugar beet plant which includes such a mutation and can be used in accordance with the present invention has been deposited with the National Collection of Industrial, Food and Marine Bacteria, Abegaeep, UK, under the number of the National Collection of Industrial, Food and Marine Bacteria, under the number of the National Collection of Bacteria 41705 on March 12, 2010.

In an even better version, the present invention relates to the use of one or more inhibitors

AI 5 herbicides in common beet mutants, in the optimal version - sugar beet mutants, which include a mutation in codon 1705-1707 of the endogenous acetolactate synthase gene (AI 5), which encodes the AI 5 protein, which includes an amino acid other than tryptophan at position 569, and in an optimal variant, the tryptophan of the wild-type AI 5 protein is substituted with leucine at position 569, and the AI 5 inhibitory herbicide(s) belong to: the group of (sulfon)amides (group (A)), which consists of: subgroup (AT) sulfonylureas, which include:

Zo amidosulfuron (СА5 ВМ 120923-37-7| (- A1-1); azimsulfuron |(ИСА5 ВМ 120162-55-21) (- А1-2); bensulfuron-methyl |(ИСА5 ВАМ 83055-99-6| ( - A1-3); chlorimuron-ethyl |(СА5 VAM 90982-32-4| (- A1-4); chlorsulfuron |(СА5 ВМ 64902-72-3) (- A1-5); cinosulfuron |(ИСА5 VAM 94593 -91-6| (- A1-6); cyclosulfamuron (CA VAM 136849-15-51 (- A1-7); ethametsulfuron-methyl |(CA5 VAM 97780-06-81 (- A1-8); ethoxysulfuron |( CA5 VM 126801-58-9| (- A1-9); flazasulfuron (CA VAM 104040-78-01) (- A1-10); flucetosulfuron (CA5 VM 412928-75-7| (- A1-11); flupyrsulfuron -methyl-sodium (CA5 VM 144740-54-5I| (- A1-12); foramsulfuron ISA5 VM 173159-57-4| (- A1-13); halosulfuron-methyl |(CA5 AM 100784-20-11 (- A1-14); imazosulfuron |(СА5 VM 122548-33-8) (- A1-15); iodosulfuron-methyl-sodium (СА5 VM 144550-36-7| (- A1-16); mesosulfuron-methyl |(ИСА5 AM 208465-21-8) (- A1-17); metsulfuron-methyl (CA BM 74223-64-6) (- A1-18); monosulfuron (CA VAM 155860-63-21 (- A1-19); nicosulfuron (CA5 VM 111991-09-41 (- A1-20); orthosulfamuron (CA5 VM 213464-77-8) (- A1-21); oxasulfuron (CA VAM 144651-06-9| (- A1-22); primisulfuron-methyl |(CA5 VAM 86209-51-0| (- A1-23); prosulfuron |(CA5 VAM 94125-34-5I| (- A1-24); pyrazosulfuron-ethyl |(ICA5 VM 93697-74-6| (- A1-25); rimsulfuron (ICA5 VM 122931-48-0| (- A1-26); sulfometuron-methyl (СА VAM 74222- 97-2| (- A1-27); sulfosulfuron (CA VM 141776-32-1| (- A1-28); thifensulfuron-methyl |(CA5 VM 79277-27-3| (- A1-29); triasulfuron | (CA5 VAM 82097-50-5) (- A1-30); 60 tribenuron-methyl | ИСА5 VAM 101200-48-0) (- A1-31);

trifloxysulfuron |(CA5 VM 145099-21-4| (sodium) (- A1-32); triflusulfuron-methyl |(CA5 VM 126535-15-7| (- A1-33); tritosulfuron |(CA5 VM 142469-14- 5) (- A1-34);

MO-330 (СА5 VAM 104770-29-81) (- A1-35);

MO-620 |(СА5 AM 868680-84-6| (- A1-36);

ТН-547 |(CA5 VM 570415-88-21 (- A1-37); monosulfuron-methyl (CA VM 175076-90-11| (- A1-38); 2-iodo-M-((4-methoxy- 6-methyl-1,3,5-triazinyl)/carbamoyl|benzenesulfonamide (-A1-39); compound of the general formula (I) 5 ri M sn,

AOS Io, oo o

Osn, (), where M" means the corresponding salt of compound (I), i.e., its lithium salt (- A1-40); its sodium salt (- A1-41); its potassium salt (- A1-42); its magnesium salt (-

A1-43); its calcium salt (- A1-44); its ammonium salt (- A1-45); its methylammonium salt (- A1-46); its dimethylammonium salt (- A1-47); its tetramethylammonium salt (- A1-48); its ethylammonium salt (- A1-49); its diethylammonium salt (their A1-50); its tetraethylammonium salt (its A1-51); its propylammonium salt (A1-52); its tetrapropylammonium salt (- A1-53); its isopropylammonium salt (- A1-54); its diisopropylammonium salt (- A1-55); its butylammonium salt (their A1-56); its tetrabutylammonium salt (-

A1-57); its (2-hydroxyet-1-yl)ammonium salt (- A1-58); its bis-M, M-(2-hydroxyet-1-yl)ammonium salt (-

A1-59); its tris-M,M,M-(2-hydroxyet-1-yl)ammonium salt (their A1-60); its 1-phenylethylammonium salt (-

A1-61); its 2-phenylethylammonium salt (their A1-62); its trimethylsulfonium salt (- A1-63); its trimethyloxonium salt (- A1-64); its pyridinium salt (- A1-65); its 2-methylpyridinium salt (- A1-66); its 4-methylpyridinium salt (- A1-67); its 2,4-dimethylpyridinium salt (- A1-68); its 2,6-dimethylpyridinium salt (- A1-69); its piperidinium salt (- A1-70); its imidazolium salt (- A1-71); its morpholinium salt (5 A1-72); its 1,5-diazabicyclo|4.3.O|non-7-enium salt (- A1-73); its 1,8-diazabicyclo|5.4.Fundec-7-enium salt (- A1-74); or a compound of formula (II) or its salt

SHCHI bom (in) she and ra

M

-4 M to her

AK with in B ()) with B2 and VU, which have the values defined below in the table

A1-85

A1-86 or the compound of the formula (PI) (7 A1-87), i.e., the sodium salt of the compound (A1-83)

Fi bo her (c)

From r H in:

Mother: D -

M

AND

Osn, osn, (1) or a compound of the formula (IM) (- A1-88), i.e., the sodium salt of the compound (A1-82); because her (in)

Z AH N i t still ma" Kh r

M Y in Osn, (M subgroup of sulfonylaminocarbonyltriazolinones (subgroup ((A2)), which includes: flucarbazone-sodium (СА5 ВМ 181274-17-9) (- А2-1); propoxycarbazone-sodium (ИСА5 ВМ 181274-15- 7)| (- A2-2); thiencarbazone-methyl |(СА5 ВМ 317815-83-1| (- A2-3); subgroups of triazolepyrimidines (subgroup (AZ)), which includes: cloransulam-methyl (147150-35 -4I| (- AZ-1); diclosulam (ISA5 AM 145701-21-9) (- AZ-2); florasulam (СА5 ВМ 145701-23-1| (- АЗ-3); flumetsulam ИСА5 ВАМ 98967-40 -91 (- АЗ-4); methosulam |ИСА5 VAM 139528-85-1| (- AZ3-5); penoxsulam |ИСА5 ВМ 219714-96-21 (- AZ-6); piroxsulam (СА5 VAM 422556-08- 9| (- AZ-7); subgroup of sulfonanilides (subgroup (A4)), which includes: compounds or their salts from the group described by the general formula (1): в' в"

M--5O, SNE, at 2 in Z

My

AK

M neo Osn" (y) in which

B" is a halogen, in the optimal version - fluorine or chlorine,

IN? is hydrogen and VZ is hydroxyl, or

B: and BZ, together with the carbon atom to which they are attached, is a C-O carbonyl group, and

B" is hydrogen or methyl; more specifically, compounds of the following chemical structure from (A4-1) to (A4-8)

N y: 4 o-- sleep um o (c)

E M Osn,

What va 5 OSN" (AK-1)

N yh "y o-- sn

From the Academy of Sciences: m on o N

E M osn"

What is the foundation, (Ad-g)

N kh "i

Odev // t Mn on o N

E M osn"

What is the foundation, (A-Z)

N ykh «i o-- sn 5 il // m o (c)

SI M osn, y va

OSN", (A4-4)

N yh "i o-- il m on o N si M O sn" that va o sn, (AB)

N kh "i

Oshev / Mn on o Nsi M Osn» schiva osn, (Av)

N y: 4

Opera / Mn o (in)

E M Osn,

What is the foundation, (AA-7)

No. 4

Oshev / "Mn o (c) si M Osn" scho va osn" (AA-8) 5 groups of imidazolinones (group (B1)), which include: imazametabenzmethyl |(ИСА5 АМ 81405-85-8) (- Б1- 1); imazamox (ICA5 VAM 114311-32-91 (- B1-2); imazapic (CA5 VAM 104098-48-81 (- B1-3); imazapir (ICA5 VAM 81334-34-11 (- B1-4 );

ZUR-298 |ISA5 VAM 557064-77-41 (- B1-7);

ZUR-300 |SA5 VM 374718-10-21 (- B1-8).

groups of pyrimidinyl (thio)benzoates (group (C)), which includes: subgroup of pyrimidinyloxybenzoic acids (subgroup (C1)), which includes: sodium bispyribac (СА5 ВМ 125401-92-5| (- С1-1); pyribenzoxime |(СА5 ВМ 168088-61-71 (- С1-2); pyriminobac-methyl |(СА5 ВМ 136191-64-5| (- С1-3); pyribambenz-isopropyl (СА ВАМ 420138-41-6) ( - С1-4); pyribambenz-propyl (СА ВАМ 420138-40-5) (- С1-5); subgroup of pyrimidinylthiobenzoic acids (subgroup (С2)), which includes: pyriphthalide (СА ВАМ 135186-78-6Й (- C2-1); sodium pyrithiobac (ISA5 VM 123343-16-81 (- C2-2).

In this context, "tolerance" or "tolerant" means that the use of one or more AI 5-inhibiting herbicides belonging to any of the above groups (A), (B), (C) does not cause obvious consequences concerning physiological functions / phytotoxicity when applied to common beet plants, in particular, sugar beet, which contains a polypeptide

AI 5, which includes a mutation at position 569, while the application of the same amount of the corresponding AI 5 inhibitory herbicide(s) to intolerant plants of common beet leads to significant negative consequences concerning the growth of the plant, its physiological functions, or shows phytotoxic symptoms. The quality and quantity of effects observed may depend on the chemical composition of the respective inhibitor(s) used. 5 herbicide(s), dose rate and time of application, as well as growth conditions / stage of development of the plants to be treated.

Unless specifically stated otherwise, the term "at least"? used before a list of items shall be understood as referring to each item listed. Specialists in this field will recognize or, through routine experimentation, will be able to verify the possibility of many equivalent variants of the embodiment of the described invention. These equivalents are within the scope of the present invention.

Throughout this specification and in the following claims, unless the context otherwise requires, the word "include" and its variants such as "includes" and "including" shall be understood to mean the inclusion of an integer or step, or groups of integers or

Of stages, but not excluding any integer or stage, or group of integers or stages.

The word "comprise" and variants thereof, on the one hand, and the word "comprise" and similar variants thereof, on the other hand, may be used interchangeably throughout the text of this specification and the corresponding claims, without preference being given to either.

In the context of this description, the term "transgenic" or "genetically modified" means that the gene - which may be taken from the same or a different species - has been incorporated into the plant through a suitable biological vehicle, such as Adgobasiegt isteiasiepe, or by any other physical by a method such as protoplast transformation or particle bombardment, and this gene is able to be expressed in a new environment, i.e., in a genetically modified organism (GMO).

According to the above definition, the term "non-transgenic" or "not genetically modified" means the exact opposite, that is, the absence of inclusion of the corresponding gene through a suitable biological carrier or by any other physical means. However, a mutated gene can be transferred through pollination, naturally or through a selection process, to create another plant that is not transgenic with respect to that particular gene. An "endogenous" gene means a plant gene that has not been incorporated into the plant through the use of genetic engineering techniques. "Amino acid other than tryptophan" (denoted as "Tgr" in the three-letter code or "Mu" in the equivalent one-letter code) means any naturally occurring amino acid other than tryptophan. These natural amino acids include alanine (A), arginine (NK), asparagine (M), aspartate (0), cysteine (C), glutamine (0), glutamate (E), glycine (C), histidine (H), isoleucine (1), leucine (I), lysine (K), methionine (M), phenylalanine (P), proline (P), serine (5), threonine (T), tyrosine (U), or valine (M).

However, in the optimal version, an amino acid other than tryptophan (belonging to the group of neutral-polar amino acids) at position 569 of protein A! 5, is an amino acid with physicochemical properties different from those of tryptophan, that is, one that belongs to any of the amino acids that exhibit neutral-nonpolar, acidic or basic properties. In an even better embodiment, the amino acid other than tryptophan is selected from the group consisting of alanine, glycine, isoleucine, leucine, methionine, phenylalanine, proline, valine, and arginine. In an even better embodiment, the aforementioned amino acid is a neutral non-polar 60 amino acid such as alanine, glycine, isoleucine, leucine, methionine, phenylalanine, proline or valine. Particular preference among the above-mentioned amino acids is given to such as alanine, glycine, isoleucine, leucine, valine. Glycine and leucine are considered even better. The greatest preference is given to leucine. "СА5 ВМ" in square brackets after the names (common names) indicated under groups from A to C corresponds to the "registration number for SPetis! ABzigasie begmise", which is an accepted registration number that allows for the precise classification of the specified substances, since "СА5

VM", among other things, distinguishes between isomers, including stereoisomers.

Inhibitory A! 5 herbicides, which are optimally used to combat unwanted vegetation on areas where beet plants are grown, optimally - sugar beet, and normal beet plants, optimally - sugar beet plants contain protein A! 5, which is encoded by the endogenous AI 5 gene, which includes an amino acid other than tryptophan at position 569, thus providing tolerance to the AI 5 inhibitory herbicide(s) according to the present invention, which belong to group (A), are: amidosulfuron (CA5 VM 120923-37-7| (- A1-1); chlorimuron-ethyl |(CA5 VAM 90982-32-4| (- A1-4); ethametsulfuron-methyl |(CA5 VAM 97780-06 -81 (- A1-8); ethoxysulfuron |(СА5 ВМ 126801-58-9| (- А1-9); flupyrsulfuron-methyl-sodium (СА5 ВМ 144740-54-5I (- А1-12); foramsulfuron ИСА5 ВМ 173159-57-4| (- A1-13); iodosulfuron-methyl-sodium (CA5 VM 144550-36-7| (- A1-16); mesosulfuron-methyl |(CA5 VM 208465-21-8) (- A1 -17); metsulfuron-methyl |(CA5 VM 74223-64-6) (- A1-18); monosulfuron (CA VAM 155860-63-21 (- A1-19); nicosulfuron (CA5 VM 111991-09-4| (- A1-20); sulfosulfuron (CA VM 141776-32-1) (- A1-28); thifensulfuron-methyl |(CA5 VM 79277-27-3| (5 A1-29); tribenuron-methyl |(CA5 VAM 101200-48-0) (- A1-31); 2-iodo-M-(4-methoxy-6-methyl-1,3,5-tr yazinyl)/carbamoyl|renzol-sulfonamide (-A1-39);

Sodium salt of 2-iodo-M-((4-methoxy-6-methyl-1,3,5-triazinyl)ucarbamoyl|renzol-sulfonamide (-1-41); (A1-83) or its sodium salt (- A1-87); propoxycarbazone-sodium (СА5 ВМ 181274-15-7| (5 A2-2); thiencarbazone-methyl (СА ВМ 317815-83-1|) (- А2-3); florasulam (СА5 ВМ 145701- 23-1) (- AZ-3); methosulam (SA VM 139528-85-1| (- AZ-5); piroxsulam (SA VM 422556-08-9| (- AZ-7) (A4-1); (A4-2) and (A4-3).

AIII 5 inhibitory herbicides, which are given special preference for use to combat unwanted vegetation in areas where beet (preferably sugar beet) is grown, and beet plants (preferably sugar beet) contain the protein AI 5, which is encoded by endogenous AI 5 genome, which includes an amino acid other than tryptophan at position 569, thus providing tolerance to the AI 5 inhibitory herbicide(s) according to the present invention, which belong to group (A), are: amidosulfuron ( CA5 BM 120923-37-7| (- A1-1); foramsulfuron (CA5 BM 173159-57-4| (- A1-13); iodosulfuron-methyl-sodium (CA5 BM 144550-36-7| (- A1- 16); 2-iodo-M-((4-methoxy-6-methyl-1,3,5-triazinyl)/carbamoyl|benzene-sulfonamide (- A1-39); sodium salt of 2-iodo-M-(( 4-methoxy-6-methyl-1,3,5-triazinyl)ucarbamoyl|renzol-sulfonamide

A1-41;

A1-83 or its sodium salt (-A1-87); thiencarbazone-methyl (CA VM 317815-83-1) (- A2-3).

Another AI 5-inhibiting herbicide, which is preferred for the control of unwanted vegetation in areas where beet (preferably sugar beet) is grown, and beet plants (preferably sugar beet) contain AI 5 protein, which is encoded endogenous AI 5 gene, which includes an amino acid,

other than tryptophan, at position 569, thus providing tolerance to the AI 5 inhibitory herbicide(s) according to the present invention, which belongs to group (B), is: imazamox |(СА5 ВМ 114311-32-9| (- B1-2).

Another AI 5-inhibiting herbicide, which is preferred for the control of unwanted vegetation in areas where beet (preferably sugar beet) is grown, and beet plants (preferably sugar beet) contain AI 5 protein, which is encoded endogenous AI 5 gene that includes an amino acid other than tryptophan at position 569, thus providing tolerance to the AI 5 inhibitory herbicide(s) of the present invention, which belongs to group (C), is: bispyribac- sodium (CA5 VM 125401-92-51) (- C1-1).

It should also be understood that with respect to all of the above AI 5 inhibitory herbicides, and if they have not already been specified through the corresponding CA5 VM, all application forms, such as acids and salts, can be used according to the invention.

In addition, the inhibiting A 5 herbicide(s) intended for use according to the invention may include other components, for example, agrochemically active compounds of a different type of mechanism of action and/or auxiliaries for formulation and/or impurities that are customary in the field of crop protection, or can be used together with them.

In an optimal embodiment, the herbicide combinations intended for use according to the invention include an effective amount of AI 5 inhibitory herbicide(s) that belong to groups (A), (B) and/or (C) and/or have synergistic action A synergistic effect can be observed, for example, when using one or more AI 5 inhibitory herbicide(s) belonging to groups (A), (B) and/or (C) together, for example, in the form of a joint formulation or tank mixture; however, they can also be observed when the active compounds are applied at different times (fractional application). It is also possible to apply herbicides or combinations of herbicides in multiple portions (sequential application), such as pre-emergence application followed by post-emergence applications or early post-emergence application followed by mid or late post-emergence application. At the same time, preference is given to the joint or almost simultaneous application of 5 AI-inhibiting herbicides belonging to groups (A), (B) and/or (C) of this combination.

The synergistic effect makes it possible to reduce the application rates of individual AI5 inhibitors

From herbicides, to achieve higher efficiency with the same application rate, allows to fight against species that were previously uncontrolled (skips), to fight against species that are tolerant or resistant to individual inhibiting A 5 herbicides or to several inhibiting AI5 herbicides, allows to extend the period of application and/or reduce the number of separate applications required, and as a result, the user obtains weed control systems that have advantages from an economic and environmental point of view.

All herbicides to be used in accordance with the present invention are acetolactate synthase (A5)-inhibiting herbicides (which may also alternatively or interchangeably be referred to as "AI5-inhibiting herbicides") and thus inhibit protein biosynthesis in plants.

The application rate of AI 5 inhibiting herbicides belonging to groups (A), (B) or (C) (as defined above) can vary widely, for example, from 0.001 g to 1500 g aiga (aga hereafter means " of active ingredient per hectare" - based on 100 95 pure active compound). Herbicides that belong to classes A, B and C according to this invention, applied at a rate of application from 0.001 g to 1500 g ai/ha, in the optimal version - compounds A1-1; A1-4; A1-8; A1-9; A1-12; A1-13; A1-16; A1-17; A1-18; A1-19; A1-20; A1-28; A1-29; A1-31; A1-39; A1-41; A1-83; A1-87; A2-2; A2-3; AZ-3; AZ-5; AZ-7, A4-3 control, when applied within the limits of pre-emergence and post-emergence application, a relatively wide range of harmful plants, for example, annual and perennial monocotyledonous and dicotyledonous weeds, as well as unwanted cultivated plants (together also defined as "unwanted vegetation").

In many cases of application according to the invention, application rates are usually lower, for example, in the range from 0.001 g to 1000 g ai/ha, in the optimal version - from 0.1 g to 500 g ai/ha, in an even better version - from 0 .5 g to 250 g AI/ha, in the best version - from 1.0 g to 200 g AI/ha. In cases of application of several inhibiting AI5 herbicides, the amount represents the total amount of all applied AI5 inhibiting herbicides.

For example, the combinations of AI5-inhibiting herbicides (which belong to groups (A), (B) and/or (C)) used according to the invention allow to synergistically increase the activity in such a way that it unexpectedly far exceeds the activity that can be achieved with individual application AI-inhibiting 5 herbicides (which belong to groups (A), (B) and/or (C)).

For combinations of AI-inhibiting 5 herbicides, the optimal conditions are explained below.

Of particular interest according to this invention is the use of herbicidal compositions for combating unwanted vegetation on the areas where beet plants are grown, in the optimal version - sugar beet, which have the following content of inhibiting AI 5 herbicides: (A1-1) and (A1-4); (A1-1) and (A1-8); (A1-1) and (A1-9); (A1-1) and (A1-12); (A1-1) and (A1-13); (A1-1) and (A1-16); (A1-1) and (A1-17); (A1-1) 4 (AMV); (A1-1) and (A1-19); (A1-1) 4(A1-20); (A1-1) and (A1-28); (A1-1) 4 (A1-29); (A1-1) and (A1-31); (A1-1) 4 (AT1-39); (A1-1) (A1-41); (A1-1) 4 (A1-83); (A1-1) and (A1-87); (A1-1) - (A2-2); (A1-1) and (A2-3); (A1-1) - (AZ-3); (A1-1) and (AZ-5); (A1-1) 4 (AZ-7); (A1-1) - (A4-1); (A1-1) and (A4-2); (A1-1) - (A4-3); (A1-4) and (A1-8); (A1-4) 4 (A1-9); (A1-4) 4 (A1-12); (A1-4) and (A1-13); (A1-4) and (A1-16); (A1-4) 4 (A1-17); (A1-4)3 and (A1-18); (A1-4) and (A1-19); (A1-4) and (A1-20); (A1-4) 4 (A1-28); (A1-4) and (A1-29); (A1-4) 4 (A1-31); (A1-4) and (A1-39); (A1-4)3 4(A1-41); (A1-4) and (A1-83); (A1-4) 4 (A1-87); (A1-4) and (A2-2); (A1-4) 4 (A2-3); (A1-4) i- (AZ-3); (A1-4) 4 (AZ-5); (A1-4) I (AZ-7); (A1-4) 4 (A4-1); (A1-4) 4 (Ad-2); (A1-4) with (A4-3); (A1-8) and (A1-9); (A1-8) 4 (A1-12); (A1-8) and (A1-13); (A1-8) 4 (A1-16); (A1-8) and (A1-17); (A1-8) 4 (A1-18); (A1-8) and (A1-19); (A1-8) 4(A1-20); (A1-8) and (A1-28); (A1-8) 4 (A1-29); (A1-8) and (A1-31); (A1-8) 4 (A1-39); (A1-8) h(A1-41); (A1-8) 4 (A1-83); (A1-8) and (A1-87); (A1-8) and (A2-2); (A1-8) i- (A2-3); (A1-8) and (AZ-3); (A1-8) and (AZ-5); (A1-8) -- (AZ-7); (A1-8) -- (A4-1); (A1-8) 4 (A4-2); (A1-8) -- (A4-3); (A1-9) and (A1-12); (A1-9) 4 (A1-13); (A1-9) and (A1-16); (A1-9) and (A1-17); (A1-9) with (A1-18); (A1-9) 4 (A1-19); (AT1-9) K(A1-20); (A1-9) 4 (A1-28); (A1-9) and (A1-29); (A1-9) 4 (A1-31); (A1-9) and (A1-39); (A1-9) 4(A1-41); (A1-9) and (A1-83); (A1-9) 4 (A1-87); (A1-9) and (A2-2); (A1-9) 4 (A2-3); (A1-9) -- (AZ-3); (A1-9) and (AZ-5); (A1-9) and (AZ-7); (A1-9) 4 (A4-1); (A1-9) and (A4-2); (A1-9) 4 (A4-3); (A1-12) 4. (A1-13); (A1-12) and (A1-16); (A1-12) and (A1-17); (A1-12) 4 (A1-18); (A1-12) 4. (A1-19); (A1-12) (A1-20); (A1-12) and (A1-28); (A1-12) and (A1-29); (A1-12) 4. (A1-31); (A1-12) and (A1-39); (A1-12) (A1-41); (A1-12) 4 (A1-83); (A1-12) 4. (A1-87); (A1-12) and (A2-2); (A1-12) and (A2-3); (A1-12) 4 (AZ-3); (A1-12) 4 (AZ-5); (A1-12) and (AZ-7); (A1-12) 4 (AD-1); (А1-12), - (АЯ-2); (A1-12) and (A4-3); (A1-13) 4. (A1-16); (A1-13) - (A1-17); (A1-13) and (A1-18); (A1-13) and (A1-19); (A1-13) h(A1-20); (A1-13) and (A1-28); (A1-13) 4 (A1-29); (A1-13) 4 (A1-31); (A1-13) 4 (A1-39); (A1-13) n(A1-41); (A1-13) 4 (A1-83); (A1-13) and (A1-87); (A1-13) and (A2-2); (A1-13) - (A2-3); (A1-13) 4 (AZ-3); (A1-13) - (AZ-5); (A1-13) 4 (AZ-7); (A1-13) - (A4-1); (A1-13) and (A4-2); (A1-13) - (A4-3); (A1-16) 4 (A1-17); (A1-16) - (A1-18); (A1-16) - (A1-19); (A1-16) 4(A1-20); (A1-16) 4 (A1-28); (A1-16) - (A1-29); (A1-16) and (A1-31); (A1-16) 4 (A1-39); (A1-16) 4(A1-41); (A1-16) and (A1-83); (A1-16) 4 (A1-87); (A1-16) - (A2-2); (A1-16) 4 (A2-3); (A1-16) - (AZ-3); (A1-16) 4 (AZ-5); (A1-16) - (AZ-7); (A1-16) 4 (A4-1); (A1-16) - (A4-2); (A1-16) 4 (A4-3); (A1-17) 4. (A1-18); (A1-17) and (A1-19); (A1-17) n(A1-20); (A1-17) 4 (A1-28); (A1-17) 4. (A1-29); (A1-17) and (A1-31); (A1-17) and (A1-39); (A1-17) 4(A1-41); (A1-17) 4. (A1-83); (A1-17) and (A1-87); (A1-17) - (A2-2); (A1-17) and (A2-3); (A1-17) 4 (AZ-3); (A1-17) - (AZ-5); (A1-17) 4 (AZ-7); (A1-17) - (A4-1); (A1-17) 4 (A4-2); (A1-17) - (A4-3); (A1-18) 4 (A1-19); (A1-18) (A1-20); (A1-18) and (A1-28); (A1-18) -- (A1-29); (A1-18) 4 (A1-31); (A1-18) - (A1-39); (A1-18) (A1-41); (A1-18) 4 (A1-83); (A1-18) 4 (A1-87); (A1-18) - (A2-2); (A1-18) - (A2-3); (A1-18) 4 (AZ-3); (A1-18) 4 (AZ-5); (A1-18) - (AZ-7); (A1-18) and (A4-1); (A1-18) - (A4-2); (A1-18) 4 (A4-3); (A1-19) h(A1-20); (A1-19) and (A1-28); (A1-19) and (A1-29); (A1-19) 4 (A1-31); (A1-19) 4 (A1-39); (A1-19) (A1-41); (A1-19) 4 (A1-83); (A1-19) 4 (A1-87); (A1-19) 4 (A2-2); (A1-19) and (A2-3); (A1-19) 4 (AZ-3); (A1-19) - (AZ-5); (A1-19) 4 (AZ-7); (A1-19) - (A4-1); (A1-19)) 4 (Ad-2); (A1-19) - (A4-3); (A1-20) 4 (A1-28); (A1-20) and (A1-29); (A1-20) and (A1-31); (A1-20) 4 (A1-39); (A1-20) h(A1-41); (A1-20) and (A1-83); (A1-20) and (A1-87); (A1-20) and (A2-2); (A1-20) 4 (A2-3); (A1-20) -- (AZ3-3); (A1-20) and (AZ-5); (A1-20) 4 (AZ-7); 60 (A1-20) 4 (A4-1); (A1-20) - (A4-2); (A1-20) 4 (A4-3);

(A1-28) 4 (A1-29); (A1-28) and (A1-31); (A1-28) and (A1-39); (A1-28) 4(A1-41); (A1-28) 4 (A1-83); (A1-28) and (A1-87); (A1-28) and (A2-2); (A1-28) and (A2-3); (A1-28) 4 (AZ-3); (A1-28) -- (AZ-5); (A1-28) 4 (AZ3-7); (A1-28) 4 (A4-1); (A1-28) 4 (A4-2); (A1-28) -- (A4-3); (A1-29) 4. (A1-31); (A1-29) -- (A1-39); (A1-29) (A1-41); (A1-29) 4 (A1-83); (A1-29) 4. (A1-87); (A1-29) and (A2-2); (A1-29) and (A2-3); (A1-29) 4 (AZ-3); (A1-29) 4 (AZ-5); (A1-29) from (AZ-7); (A1-29) 4 (A4-1); (A1-29) -- (A4-2); (A1-29) -- (A4-3); (A1-31) 4 (A1-39); (A1-31) to (A1-41); (A1-31) 4 (A1-83); (A1-31) 4 (A1-87); (A1-31) 4 (A2-2); (A1-31) and (A2-3); (A1-31) 4 (AZ3-3); (A1-31) - (AZ-5); (A1-31) 4 (AZ3-7); (A1-31) 4 (A4-1); (A1-31) and (A4-2); (A1-31) 4 (A4-3); (A1-39) 4(A1-41); (A1-39) -- (A1-83); (A1-39) -- (A1-87); (A1-39) and (A2-2); (A1-39) 4 (A2-3); (A1-39) -- (AZ3-3); (A1-39) -- (AZ-5); (A1-39) 4 (AZ3-7); (A1-39) 4 (A4-1); (A1-39) -- (A4-2); (A1-39) 4 (A4-3); (A1-41) 4 (A1-83); (A1-41) and (A1-87); (A1-41) and (A2-2); (A1-41) and (A2-3); (A1-41) 4 (AZ-3); (A1-41) and (AZ-5); (A1-41) 4 (AZ3-7); (A1-41) -- (A4-1); (A1-41) 4 (A4-2); (A1-41) with (A4-3); (A1-83) 4 (A2-2); (A1-83) - (A2-3); (A1-83) 4 (AZ3-3); (A1-83) - (AZ3-5); (A1-83) 4 (AZ-7); (A1-83) -- (A4-1); (A1-83) 4 (A4-2); (A1-83) - (A4-3); (A1-87) 4 (A2-2); (A1-87) - (A2-3); (A1-87) 4 (AZ3-3); (A1-87) - (AZ-5); (A1-87) 4 (AZ3-7); (A1-87) 4 (A4-1); (A1-87) -- (A4-2); (A1-87) 4 (A4-3); (A2-2) with (A2-3); (A2-2) 4 (AZ3-3); (A2-2) and (AZ-5); (A2-2) with (AZ-7); (A2-2) with (A4-1); (A2-2) 4 (A4-2); (A2-2) -- (A4-3); (A2-3) and (AZ-3); (A2-3) 4 (AZ3-5); (A2-3) -- (AZ-7); (A2-3) and (A4-1); (A2-3) 4 (A4-2); (A2-3) -- (A4-3); (AZ-3) - (AZ3-5); (AZ-3) 4 (AZ3-7); (AZ-3) -- (A4-1); (AZ-3) 4 (A4-2); (AZ-3) -- (A4-3); (AZ-5) -- (AZ-7); (AZ-5) 4 (A4-1); (AZ-5) -- (A4-2); (AZ-5) -- (A4-3); (AZ-7) and (A4-1); (AZ-7) 4 (A4-2); (AZ-7) -- (A4-3); (A-1) -- (A4-2); (A4-1) with (A4-3); and

Co. Ltd.) (A4-2) -- (A4-3);

In addition, AI 5 inhibitory herbicides intended for use according to the invention may include other components, for example, agrochemically active compounds of a different type of mechanism of action and/or auxiliaries for formulation and/or admixtures, which are customary in the field of crop protection, or can be used together with them.

AI 5 inhibiting herbicide(s) to be used according to the invention, or combinations of different such AI 5 inhibiting herbicides, may also include various agrochemically active compounds, for example, from the group of antidotes, fungicides, insecticides, or from the group of auxiliary substances for formulations and admixtures that are customary in the field of crop protection.

In another embodiment, the invention relates to the use of an effective amount of AI 5 inhibitory herbicide(s) (i.e., representatives of groups (A), (B) and/or (C)) and non-inhibitory

AI 5 herbicides (that is, herbicides that demonstrate a mechanism of action other than inhibition of the enzyme AI5 |acetohydroxy acid synthase; EC 2.2.1.6| (herbicides of the OO group) in order to achieve a synergistic effect to control unwanted vegetation. Such a synergistic effect can be observed, for example , when using one or more A5 inhibiting herbicides (that is, representatives of groups (A), (B) and/or (C)) and one or more non-A5 inhibiting herbicides (group Y herbicides) together, for example, in the form of a joint formulation or tank mix; however, they can also occur when the active compounds are applied at different times (fractional application). It is also possible to apply AI 5-inhibiting herbicides and non-AI 5-inhibiting herbicides in multiple doses (sequential application), such as pre-emergence followed by post-emergence applications or early post-emergence application followed by mid or late post-emergence application. carrying herbicides (A), (B) and/or (C)) and (O) of this combination.

Acceptable herbicides for joint application together with AI 5-inhibiting herbicides are, for example, the following herbicides, which differ in structure from herbicides belonging to groups (A), (B) and (C), as defined above, in the optimal version - herbicidal active compounds whose action is based on |inhibition, for example, acetyl-coenzyme A carboxylase, RB5 I, RB5 II, HPPOO, phytoin desaturase, protoporphyrinogen oxidase, glutamine synthetase, cellulose biosynthesis, 5-enolpyruvylshikimate Z-phosphate synthetase, as described, for example , in the publication M/eed VResagsj 26, 441-445 (1986), or "TNe Resisiside Mapia!", 14 60 eaiiop, Te Viiyivy Stor Rgoiesiop Soipsiii, 2007, or the 15th edition of 2010, or in the corresponding manual " e-Reviiiside Mapiai!', Magwiop 5 (2010), published by the British Crop Protection Council (hereafter also abbreviated as 'RM'), and in the literature cited therein. Lists of common names are also contained in the compendium "Te

Sotrepaiit oi Reziiside Sottop Matev" on the Internet. Herbicides known from the literature (in brackets after the general name are further classified by designations from 01 to 0426), which can be combined with inhibiting AI 5 herbicides from groups (A), (B) and/ or (C) and are to be used in accordance with the present invention are, for example, the following active compounds: (note: herbicides are indicated either by "common name" as defined by the International Organization for Standardization (ISO) or by chemical name, as appropriate - together with the traditional code number, in any case - indicating all forms of use, such as acids, salts, esters and isomers, such as stereoisomers and optical isomers, in particular the commercial form or commercial forms, unless the context indicates Other The given reference refers to one form of application, and in some cases to two or more forms of application: acetochlor (- 01), acibenzolar (- 02), acibenzolar-5-methyl (- 03), adifluorfen (- 04), acifluorfen-sodium (- 05), aclonifen (- 06), alachlor (- 07), alidochlor (- 08), aloxidim (- 09), aloxidim sodium (- 010), ametrin (- 011) , amicarbazone (- 012), amidochlor (- 013), aminocyclopyrachlor (- 014), aminopyralid (- 015), amitrole (- 016), ammonium sulfamate (- 017), ancimidol (- 018), anilophos (- 019), asulam (- 020), atrazine (- 021), azafenidine (- 022), aziprothrin (- 023), beflubutamide (- 024), benazolin (- 025), benazolin-ethyl (- 26), bencarbazone (- 027), benfluralin (- 028), benfurezate (- 029), benzulid (- U30), bentazon (- 031), benzphendizone (- 032), benzobicyclone (- 033), benzofenap (- 034), benzofluor (- 035), benzoylprop ( - 036), bicyclopyrone (- 037), bifenox (- 038), bilanaphos (- 039), bilanaphos sodium (- 040), bromacil (- 041), bromobutide (- 042), bromophenoxime (- 043), bromoxynil ( - 044), bromuron (- 045), buminaphos (- 046), buoxinone (- 047), butachlor (- 048), butafenacil (- 049), butamiphos (- 050), butenachlor (- 051), butralin (- 052 ), butroxidim (- 053), butylate (- 054), cafenstrol (- 055), carbetamide (- 056), carfentrazone (- 057), carfentrazone-ethyl (- 058), clomethoxifene (- 059), chloramben (- 060), chlorazifop (- 061), chlorazifop-butyl (- рб2), chlorbromuron (- 063), chlorbufam (- 064), chlorfenac (- 065), chlorfenac-sodium (- 066), chlorfenprop (- 067), chlorflurenol (- 068), chlorflurenol-methyl ( - 069), chloridazone (-

Zo rt7b), chlormequat chloride (- 071), chlornitrophen (- 072), chlorophthalim (- 073), chlorthal-dimethyl (- 074), chlorotoluron (i- 075), cinidone (- 076), cinidone-ethyl (- 077), cinmethylin (- 078), clethodim (i- 079), clodinafop (- 080), clodinafop-propargyl (- 081), clofencet (- 082), clomazone (- 083), clomeprop (- 084), cloprop ( - 085), clopyralid (- ОЮ86), cloransulam (- 087), cloransulam-methyl (- 088), cumiluron (- 089), cyanamide (- 090), cyanazine (- 091), cyclanilide (- reg), cycloate ( - 093), cycloxidim (- 094), cycluron (- 095), cigalofop (- 096), cigalofop-butyl (- 097), cyperquat (- 098), cyprazine (- 099), cyprazole (- 0100), 2, 4-О0 (- 0101), 2,4-ОВ8 (- p102), diamuron/dimron (- 0103), dalapon (- 0104), diaminoside (- 0105), dazomet (- 0106), p-decanol (- 0О -107), desmedifam (- 0108), desmethrin (- 0109), detosyl-pyrazolate (- 0110), diallate (- 0111), dicamba (- 0112), dichlobenil (- 0113), dichlorprop (- 0114), dichlorprop- R (-

Or115), diclofop (- 0116), diclofop-methyl (- 0117), diclofop-P-methyl (- 0118), diethatyl (- 0119), diethatyl-ethyl (-0120), difenoxuron (- 0121), difenzoquat (- 0122), diflufenican (- 0123), diflufzopir (- 0124), diflufzopir sodium (- 0125), dimefuron (- 0126), dikegulak sodium (- 0127), dimefuron (- 0128), dimepiperate (- 0129), dimetachlor (- 0130), dimetamethrin (- 0131), dimethenamid (- 0132), dimethenamid-P (- 0133), dimetipin (- 0134), dimetrasulfuron (- 0135), dinitramine (- 0136), dinoseb (- 0137), dinoterb (- 0138), diphenamide (- 0139), dipropethrin (- 0140), diquat (- 0141), diquat-dibromide (- 0142), dithiopyr (- 0143), diuron (- 0144), ONOS (- 0145), eglinazine -ethyl (- 0146), endothal (- 0147), ERTS (- 0148), esprocarb (- 0149), etalfluralin (- 0150), ethephon (- 0151), ethidimuron (- 0152), ethiosin (- 0153), etofumesate (- 0154), ethoxyphene (- 0155), ethoxyphene-ethyl (- 0156), ethobenzanide (- 0157), B-5331 (- 2-Chloro-4-fluoro-5-(4-(3-fluoropropyl)-4 ,5-dihydro-5-oxo-1H-tetrazol-1-yl|-phenyl|-ethane lfonamide) (- 0158), E-7967 (- 3-(7-Chloro-5-fluoro-2-trifluoromethyl)-1H-benzimidazol-4-yl|-1-methyl-6-(trifluoromethyl)pyrimidine-2 ,4(1Н, ЗН)-dione) (- p159), phenoprop (-0160), fenoxaprop (- 0161), fenoxaprop-P (- 0162), fenoxaprop-ethyl (- 0163), fenoxaprop-P-ethyl (- 0164), phenoxasulfone (- 0165), fentrazamide (- 0166), fenuron (- 0167), flamprop (- 0168), flamprop-M-isopropyl (- 0169), flamprop-M-methyl (- 0170), fluazifop (- 0171), fluazifop-P (- 0172), fluazifop-butyl (- 0173), fluazifop-P-butyl (- 0174), fluazolate (- 0175), fluchloralin (- 0176), flufenaket (thiafluamide) (- 0177), flufenpyr (- 0178), flufenpyr-ethyl (- 0179), flumetralin (- 0180), flumiclorac (- 0181), flumiclorac-pentyl (- 0182), flumioxazin (- 0183), flumipropin (- 0184), fluometuron (- bo 0185), fluorodifen (- 0186), fluoroglycofen (- 0187), fluoroglycofen-ethyl (- 0188),

flupoxam (- 0189), flupropacil (- 0190), flupropanate (- 0191), flurenol (- 0192), flurenol-butyl (- 0193), fluridone (- 0194), flurochloridone (- 0195), fluroxypyr (- 0196), fluroxypyr-meptyl (- 0197), flurprimidol (- 0198), flurtamone (- 0199), fluthiacet (- rgob), fluthiacet-methyl (- 0201), fluthiamide (- 0202), fomesafen (- 203), forchlorfenuron (- 0204 ), fosamine (- 0205), furyloxyfen (- 0206), gibberellic acid (- 0207), glufosinate (- pg208), glufosinate-ammonium (- 0209), glufosinate-P (- 0210), glufosinate-P-ammonium (- 0211), glufosinate-P-sodium (- 0212), glyphosate (- 0213), glyphosate-isopropylammonium (their 0214), H-9201 (-0-(2,4-Dimethyl-b-nitrophenyl)-O-ethyl- isopropyl phosphoramidothioate) (- 0215), halosafen (- 0216), haloxyfop (- 0217), haloxyfop-P (- 0218), haloxyfop-ethoxyethyl (0219), haloxyfop-P-ethoxyethyl (- 0220), haloxyfop-methyl (- 0221 ), haloxyfop-P-methyl (- 0222), hexazinone (- 0223), НМ/-02 (- 1-"-"Dimethoxyphosphoryl)-ethyl(2,4-dichlorophenoxy)acetate) (- p224), inabenfid (- 0225), Indan ofan (- 0226), indaziflam (- 0227), indole-3-acetic acid (IAA) (- 0228), 4-indole-3-ylbutyric acid (IBA) (- 0229), ioxynil (- 0230), irfencarbazone ( - 0231), isourea (- 0232), isopropalin (- 0233), isoproturon (- 0234), isouron (- 0235), isoxaben (- 0236), isoxachlortol (- 0237), isoxaflutol (- 0238), isoxapyriphor (- 0239 ), kKOHn-043 (- 3-(15-(Difluoromethyl)-1-methyl-3-trifluoromethyl)-1H-pyrazol-4-yl|Imethyl)sulfonyl)-5,5-dimethyl-4,5-dihydro -1,2-oxazole) (- 0240), carbutylate (-0241), ketospiradox (- 0242), lactofen (- 0243), lenacil (- 0244), linuron (- 0245), maleic acid hydrazide (- 0246),

MSRA (- 0247), MSRV (- 0248), MSRV-methyl, -ethyl and -sodium (- 0249), mecoprop (- 0250), mecoprop-sodium (- 0251), mecoprop-butoethyl (- 0252), mecoprop- P-butoyl (- 0253), mecoprop-

P-dimethylammonium (their 0254), mecoprop-P-2-ethylhexyl (their 0255), mecoprop-P-potassium (- 0256), mefenaket (- 0257), mefluidide (- 0258), mepiquat chloride (- 0259), mesotrione (- 0260), metabenzthiazuron (- 0261), metham (- 0262), metamifop (- 0263), metamitron (- 0264), metazachlor (- 0265), metazol (- 0266), methiopyrsulfuron (- 0267), methiozolin ( - 0268), methoxyphenone (- 0269) methyldimron (- 0270), 1-methylcyclopropene (- 00271), methyl isothiocyanate (- 0272), metobenzuron (- 0273), metobromuron (- 0274), metolachlor (- рг75), З-metolachlor (- 0-276), methoxuron (- 0277), metribuzin (- 0278), molinate (- 0279), monalide (- 0280), monourea (- 0281), monourea-dihydrosulfate (- 0282), monolinuron (- 0283) , monosulfuron-ester (- 0284), monuron (- 0285), MT-128 (- 6-Chlor-M-(2E)-3-

Zo chloroprop-2-en-1-yl|-5-methyl-M-phenylpyridazine-3-amine) (- 0286), MT-5950 (- M-III-Chlor-4-(1- methylethyl)-phenyl| -2-methylpentanamide) (- 0287), MOasO-011 (- 0288), naproanilide (- 0289), napropamide (- 0290), naptalam (- 0291), MO-310 (-4-(2,4-Dichlorobenzoyl) -1-methyl-5- benzyloxypyrazole) (- 0292), neburon (- 0293), nipyraclofen (- 0294), nitralin (- 0295), nitrofen (- 0296), sodium nitrophenolate (mixture of isomers) (- 0297), nitroforfen (- 0298), nonanoic acid (- 0299), norflurazon (- 0300), orbencarb (- 0301), oryzalin (- 0302), oxadiargyl (- 0303), oxadiazon (- 0304), oxacyclomefon (- 0305), oxyfluorfen (- 0306), paclobutrazol (- 0307), paraquat (- 0308), paraquat dichloride (- 0309), pelargonic acid (nonanoic acid) (- 0310), pendimethalin (- 0311), pendralin (- 0312), pentanochlor ( - 0313), pentoxazone (- 0314), perfluidone (- 0315), pentoxamide (- 0317), phenizofam (- 0318), phenmedipham (- 0319), phenmedipham-ethyl (- 0320), picloram (- 0321), picolinafen ( - 0322), pinoxaden (- 0323), piperophos (- 0324), pyrifenop (- 0325), pyrifenop-butyl (- 0326), pretilachlor (- 0327), probenazole (- 0328), profluazole (- 0329), procyazine (- 0330), prodiamine (- 0331), prifluralin (- 0332), profoxidim (- 0333), prohexadione (- 0334), prohexadione-calcium (- 0335), prohydrojasmone (- 0336), prometon (- 0337), promethrin (- 0338), propachlor (- 0339), propanil (- 0340), propaquizafop (- 0341), propazine (- 0342), propham (- p343), propisochlor (- 0344), propizamide (- 0345), prosulfalin (- 0346), prosulfocarb (- 0347), prinachlor ( - 0348), pyraclonil (- 0349), pyraflufen (- 0350), pyraflufen-ethyl (- 0351), pyrasultphotol (- 0352), pyrazolinate (pyrazolate) (- 0353), pyrazoxifene (- 0354), pyribambenz (- 0355) , pyributicarb (- 0356), pyridafol (- 0357), pyridate (- U358), pyriminobac (- 0359), pirimisulfan (- 0360), pyroxasulfone (- 0361), hinclorac (- 0362), hinmerac (- 0rz363), quinoclamine (- 0364), khizalofop (- 0365), khizalofop-ethyl (- U366), khizalofop-P (- 0367), khizalofop-P-ethyl (- 0368), Khizalofop-P--efuryl (- 0369), safluphenacil (- 0370), secbumeton (- 0371), sethoxydim (- 0372), siduron (- 0373), simazine (- 0374), symetryn (- 0375), 5M-106279 (5 Methyl-(2P)-2-(17-(2-chloro-4-(trifluoromethyl)phenoxy|-2g-naphthyloxy)- propanoate) (- 0376), sulcotrione (- 0377), sulfate (SOES) (- 0378), sulfentrazone (- 0379), sulfonate (glyphosate-trimesium) (- 0380), 5UM-523 (- 0381), 5MR-249 (- 1-Ethoxy-3-methyl-1-oxobut-3-en-2 -yl-5-(2-chloro-4-(trifluoromethyl)phenoxy|)|-2-nitrobenzoate) (- rz82), tebutam (- 0383), tebuthiuron (- 0384), technazol (- 0385), tefuryltrione (- 0386), tembotrione (- p387), tepraloxidim (- 0388), terbacil (- 0389), terbucarb (- 0390), terbuchlor (- 0391), 60 terbumeton (- 0392), terbuthylazine (- 0393), terbutrin (- 0394 ), tenylchlor (- 0395),

Thiafluamide (- 0396), Thiazafluron (- 0397), Thiazopyr (- 0398), Thidiazimin (- 0399), Thidiazuron (- ра400), Thiobencarb (- 0401), Thiocarbazyl (- 0402), Topramesone (- 0403), Tralkoxidim ( - 0404), trialate (- 0405), triaziflam (- 0406), triazofenamide (- 0407), trichloroacetic acid (TCA) (- 0408), triclopyr (- 0409), tridiphan (- 0410), trietazin (- 0411), trifluralin (- 0412), trimeturon (- 0413), trinexapak (- 0414), trinexapak-ethyl (- 0415), cytodef (- 0416), uniconazole (- 0417), uniconazole-P (- 0418), vercholate (- 0419 ), 20-0862 (- 3,4-Dichloro-M-(2-K4,6-dimethoxypyrimidin-2-yl)/oxy|Ibenzyl)aniline) (- 0420) and the following compounds, which are determined by their chemical structure, respectively : (c) o (o); o (c) eta and / M x Mo Zh

Fa M Ton o and To (in) Se, / to 0-8 o o Pa:

Mn, Mn,

O v sia SI hu SI

SEZ 4 M series -

M sleep, M sleep K- - (in o

M

EYU, ssN, O

Esn, Esn,

In the optimal version - additional herbicides, which differ in structure and mechanism of action from inhibiting AI 5 herbicides, which belong to groups (A), (B) and (C), as defined above, and should be used according to the present invention to control unwanted vegetation on the areas of cultivation of common beet tolerant to AI5-inhibiting herbicides, in the optimal version - sugar beet plants, which include a mutation in codon 1705-1707 of the endogenous AI 5 gene, which encodes the AI 5 protein, which contains an amino acid other than tryptophan, in the position 569, and in the optimal variant, the tryptophan of the wild-type AI 5 protein is a substituted leucine at position 569. Related to AI 5 inhibitory herbicides belonging to groups (A), (B) and (C) are herbicides from the group, to which includes: chloridazone (- 070), clethodim (- 079), clodinafop (- 080), clodinafop-propargyl (- 081), clopyralid (- 086), cycloxidim (- 094), desmedifam (- 0108), dimethenamid (- 0132), dimethenamid-P (- 0133), etofumesate (- 0154), f enoxaprop (- 0161), fenoxaprop-P (- 0162), fenoxaprop-ethyl (- 0163), fenoxaprop-P-ethyl (- 0164), fluazifop (- 0171), fluazifop-P (- 0172), fluazifop-butyl ( - 0173), fluazifop-R-butyl (- 0174), glufosinate (- 0208), glufosinate-ammonium (- 0209), glufosinate-R (- 0210), glufosinate-R-ammonium (- 0211), glufosinate-R- sodium (-: 0212), glyphosate (- 0213), glyphosate-isopropylammonium (- 0214), haloxyfop (- 0217), haloxyfop-P (their 0218), haloxyfop-ethoxyethyl (- 0219), haloxyfop-P- ethoxyethyl (- 0220), haloxyfop-methyl (their O221), haloxyfop-P-methyl (- 0222), lenacil (- рг4и4), metamitron (- 0264), phenmedipham (- 0319), phenmedipham-ethyl (- 0320), propaquizafop

Zo (- О341), hinmerac (- 0363), khizalofop (- 0365), khizalofop-ethyl (- ЮЗ366), khizalofop-P (- 0367), khizalofop-P-ethyl (- 0368), khizalofop-P-tefuryl ( - 0369), sethoxydim (- 0372).

In an even better embodiment, additional herbicides that differ from AI5-inhibiting herbicides belonging to groups (A), (B) and (C) as defined above and which are to be used according to the invention related to AI5-inhibiting herbicides, which belong to groups (A), (B) and (C), are herbicides from the group that includes: desmedifam (- 0108), etofumesate (- 0154), glufosinate (- 0208), glufosinate-ammonium (- rgoz) , glufosinate-P (- 0210), glufosinate-P-ammonium (- 0211), glufosinate-P-sodium (- 0212),

glyphosate (- 0213), glyphosate-isopropylammonium (- 0214), lenacil (- 0244), metamitron (- 0264), phenmedipham (- 0319), phenmedipham-ethyl (- 0320).

Mixtures that contain AI 5-inhibiting herbicides and non-AI 5-inhibiting herbicides, compositions that include mixtures of one or more AI 5-inhibiting herbicides (compounds belonging to one or more groups (A), (B) and (C)) and non-inhibiting AI 5 herbicides (representatives of group (0), as defined above), which are particularly interesting from the point of view of application according to the present invention for the control of unwanted vegetation, are: (A1-1) - (0108); (A1-1) 4 (0154); (A1-1) 4 (0208); (A1-1) 4 (0209); (A1-1) - (0210); (A1-1) 4 (0212); (A1-1) 4 (0213); (A1-1) 4 (0214); (A1-1) - (0244); (A1-1) 4 (0264); (A1-1) 4 (0319); (A1-1) 4 (0320). (A1-13) 4 (0108); (A1-13) - (0154); (A1-13) 4 (0208); (A1-13) 4 (0209); (A1-13) 4 (0210); (A1-13) - (0212); (A1-13) 4 (0213); (A1-13) 4 (0214); (A1-13) I (0244); (A1-13) - (0264); (A1-13) 4 (0319); (A1-13) 4 (0320). (A1-16) 4 (0108); (A1-16) - (0154); (A1-16) 4 (0208); (A1-16) 4 (0209); (A1-16) i (0210); (A1-16) - (0212); (A1-16) 4 (0213); (A1-16) I (0214); (A1-16) I (0244); (A1-16) - (0264); (A1-16) 4 (0319); (A1-16) 4 (0320). (A1-39) 4 (0108); (A1-39) - (0154); (A1-39) 4 (0208); (A1-39) 4 (0209); (A1-39) "4 (0210); (A1-39) - (0212); (A1-39) 4 (0213); (A1-39) I (0214); (A1-39) "4 (0244); (A1-39) - (0264); (A1-39) 4 (0319); (A1-39) 4 (0320). (A1-41) 4 (0108); (A1-41) 4 (0154); (A1-41) 4 (0208); (A1-41) 4 (0209); (A1-41) 4 (0210); (A1-41) I (0212); (A1-41) 4 (0213); (A1-41) 4 (0214); (A1-41) I (0244); (A1-41) I (0264); (A1-41) 4 (0319); (A1-41) 4 (0320). (A1-83) 4 (0108); (A1-83) - (0154); (A1-83) 4 (0208); (A1-83) 4 (0209); (A1-83) 4 (0210); (A1-83) - (0212); (A1-83) 4 (0213); (A1-83) 4 (0214); (A1-83) I (0244); (A1-83) - (0264); (A1-83) 4 (0319); (A1-83) 4 (0320). (A1-87) 4 (0108); (A1-87) - (0154); (A1-87) 4 (0208); (A1-87) 4 (0209); (A1-87) 4 (0210); (A1-87) - (0212); (A1-87) 4 (0213); (A1-87) 4 (0214); (A1-87) 4 (0244); (A1-87) - (0264); (A1-87) 4 (0319); (A1-87) 4 (0320). (A2-3) - (0108); (A2-3) 4 (0154); (A2-3) 4 (0208); (A2-3) 4 (0209); (A2-3) I (0210); (A2-3) 4 (0212); (A2-3) 4 (0213); (A2-3) 4 (0214); (A2-3) - (0244); (A2-3) 4 (0264); (A2-3) 4 (0319); (A2-3) 4 (0320). (81-2) - (0108); (B1-2) 4 (0154); (B1-2) 4 (0208); (81-2) 4 (0209); (81-2) 4 (0210); (B1-2) 4 (0212); (81-2) 4 (0213); (8B1-2) 4 (0214); (81-2) - (0244); (B1-2) 4 (0264); (B1-2) 4 (0319); (8B1-2) 4 (0320). (C1-1) 4 (0108); (C1-1) 4 (0154); (C1-1) 4 (0208); (C1-1) 4 (0209); (C1-1) 4 (0210); (C1-1) - (0212); (C1-1) 4 (0213); (C1-1) 4 (0214); (C1-1) 4 (0244); (C1-1) 4 (0264); (C1-1) 4 (0319); (C1-1) 4 (0320).

The use of AI 5-inhibiting herbicides is also effective against perennial weeds that produce shoots from rhizomes, roots and other perennial organs, and which are difficult to control. In such cases, the substances can be applied, for example, in the pre-sowing, pre-emergence or post-emergence mode, for example, together or separately. Preference is given, for example, to the application in the post-emergence mode, in particular for the seedlings of harmful plants.

As specific examples, some representatives of monocotyledonous and dicotyledonous weeds can be mentioned, which can be suppressed by AI5-inhibiting herbicides, without limitation to the list of specific species.

Examples of weed species to which application according to the present invention can be effectively applied are, among others, monocotyledonous weed species, Amepa species, Aioresygiv5 species,

Arega, species of Vgaspiapa, species of Vgotiv5, species of Oidnaga, species of Ioiiisht, species of EsPipospioa, species

Rapisit, species of Raiagi5, species of Roa, species of 5eiagia, as well as species of Suregi from the annual group, and among the perennial species - Adgorugop, Supodop, Itregaia and Zogupyt, as well as perennial species of Suregi.

In the case of dicotyledonous weed species, the spectrum of action extends to genera, such as, for example, species

Arshyop, species of Atagapipyh, species of SPpeporodiit, species of SPhuzapipetite, species Site, species

Irotoea, species of Cospia, species of I atisht, species of Maiygisagia, species of RGagtbiyy5, species of Roiudopyth, species of 5ida, species of Biparie, species of Boiagisht, species of BieyiIaga, species of Megopis and Mioia,; species Hapiyisht among annual and SopmoiYimtsiv5, Sigviit, Vytekh and Apetivia in the case of perennial weeds.

In an optimal variant, a common beet plant, in an optimal variant - a sugar beet plant, to which one or more inhibitory AI5 herbicides are applied, alone or in combination with one or more herbicides that do not belong to the class of inhibitory AI5 herbicides, to control unwanted vegetation on the areas where beet plants are grown, or, in the best case, sugar beet, and the beet plants, in the best case, sugar beet, include a mutation in codon 1705-1707 of the endogenous AI 5 gene, which encodes the AI 5 protein, which contains an amino acid, from tryptophan, at position 569, is orthoploid or anorthoploid. In this case, an orthoploid plant can optimally be haploid, diploid, tetraploid, hexaploid, octaploid, decaploid, or dodecaploid, while an anortoploid plant can optimally be triploid or pentaploid.

In the context of this description, unless expressly stated otherwise, the term "plant" means a plant at any stage of development.

A situation is possible when - depending on the respective genetic environment - common beet plants with the same genetic environment, in which such a mutation is present only heterozygously, herbicide-tolerant common beet plants, which ARE homozygous for a non-transgenic mutation of the endogenous AI 5 gene, demonstrate a better agronomic level tolerance to AI-inhibiting 5 herbicides.

In this context, "homozygous" means that the plant according to the present invention has two copies of the same allele on different DNA strands, in particular, in the AI 5 gene locus.

Accordingly, in the context of this description, the term "heterozygous" or "heterozygous" means that the plant according to the present invention has different alleles at a specific locus, in particular, at the A 5 gene locus.

Thus, the present invention relates to the use of one or more AI5-inhibiting herbicides alone or in combination with one or more non-AI5-inhibiting herbicides for weed control in areas where beets are grown, and in the best case, sugar beets, and beet plants, in the optimal variant - sugar beet plants include a mutation in codon 1705-1707 of the endogenous AI 5 gene, which encodes the AI 5 protein, which contains an amino acid other than tryptophan at position 569, and in the optimal variant, the tryptophan of the wild-type AI 5 protein is substituted by leucine at position 569.

This corresponding mutation in the position 1705-1707 of the endogenous AI 5 gene can be heterozygously present and in the optimal version can be the only mutation of the AI 5 gene. In an even better embodiment, the corresponding mutation can be homozygously present, and in the best embodiment, the corresponding mutation is homozygously present as a single mutation of the endogenous AI 5 gene.

Because of their herbicidal and plant growth-regulating properties, AI5-inhibiting herbicides belonging to one or more of groups (A), (B) and (C), alone or in combination with non-AI5-inhibiting herbicides, can be used to control harmful plants in the places of cultivation of known common beet, in the optimal version - sugar beet, as well as for tolerant or genetically modified cultivated plants that already exist or are yet to be bred. In general, transgenic plants are distinguished by specific favorable properties, in addition to tolerance to AI5-inhibiting herbicides according to the invention, for example, tolerance to non-AI5-inhibiting herbicides, resistance to plant diseases or organisms that are plant pathogens, such as some insects or microorganisms, such as fungi, bacteria or viruses. Other specific characteristics relate to, for example, the quantity, quality, storability, composition and specific constituents of the collected material. Therefore, transgenic plants are known, in which the content of starch is increased, or the quality of starch is changed, or those in which the collected material has a different fatty acid composition.

Traditional methods of obtaining new plants, which have modified properties compared to currently existing plants, consist, for example, in traditional methods of selection and creation of mutants. Alternatively, new plants with altered properties can be obtained using recombinant methods (see, for example, documents

ER-A-0221044, ER-A-0131624). For example, in various cases, the following methods were described: - modification, using recombinant technology, of cultivated plants for the purpose of modifying the starch synthesized in plants (for example, documents UUO 92/11376, MO 92/14827, MO 91/19806), - transgenic cultivated plants that show tolerance to non-inhibiting AI5 herbicides are transgenic cultured plants capable of producing Vasiyiv5 Ihipdiep5viv iohipv toxins (VIi-toxins), which make plants resistant to some pests (documents EP-A-0142924,

ER-A-0193259), - transgenic cultivated plants with a modified fatty acid composition (UMO document 91/13972).

In principle, many technologies of molecular biology are known, with the help of which it is possible to obtain new transgenic plants with modified properties; see, for example, 5atrgook 60 ei ai., 1989, Moiiesshag Siopipo, A I arogayugu Mapia!, 274 Edyiop, So Zrgipd Nagbog Iarogaigu

Rgezv, Soyd brgipa Nagrog, MU; or M/ippaskeg "Zepe ippa Kiope", MSN M/vippeit 279 Edyop 1996, or Stgivioi, "Ttepavz ip Riapi bsiepse" 1 (1996) 423-431).

To carry out such recombinant manipulations, nucleic acid molecules can be included in plasmids, which provide the possibility of mutagenesis or sequence change by recombination of DNA sequences. For example, the above-mentioned standard methods allow the exchange of bases, the deletion of subsequences, or the addition of natural or synthetic sequences. To connect DNA fragments to each other, adapters or linkers can be added to the fragments.

For example, obtaining plant cells with reduced activity of the gene product can be achieved by expressing at least one antisense RNA, sense RNA to achieve the effect of cosuppression, or by expressing at least one properly constructed ribozyme that specifically cleaves the transcripts of the aforementioned gene product.

This can be done using DNA molecules that span the entire coding sequence of the gene product, including any flanking sequences that may be present, or DNA molecules that only include parts of the coding sequence, and these parts must be long enough to produce an antisense effect. in cells It is also possible to use DNA sequences that have a high degree of homology with the corresponding sequences of the gene product, but are not completely identical to them.

When expressing nucleic acid molecules in plants, the synthesized protein can be localized in any desired compartment of the plant cell. However, to achieve localization in a specific compartment, it is possible, for example, to connect the coding region with DNA sequences that ensure localization in a specific compartment. Such sequences are known to those skilled in the art (see, for example, Vgashp eyi a!I., EMVO .. 11 (1992), 3219-3227; Mopeg eyi ai!., Rgos. Maiyi). Asad 5 OBA 85 (1988), 846-850; b5oppemaia ei ai.,

Riapi u. 1 (1991), 95-106).

Cells of a transgenic plant can be regenerated using known technologies to obtain whole plants. Thus, transgenic beetroot plants can be obtained, in the best case - sugar beet plants, the properties of which are changed

Zo due to overexpression, suppression or inhibition of homologous (- natural) genes or gene sequences or expression of heterologous (- foreign) genes or gene sequences.

The present invention also provides a method of combating unwanted vegetation on areas where beet is grown, in the optimal version - sugar beet, which includes the use of one or more AI 5 inhibitory herbicides belonging to groups (A), (B) and/or (C) , to plants (e.g. noxious plants such as monocotyledonous or dicotyledonous weeds or unwanted crop plants), seeds (seeds or vegetative reproductive organs such as tubers or parts of shoots) or to areas on which plants are grown (e.g. cultivated cultivated areas), for example, together or separately.

The present invention also provides a method of combating unwanted vegetation on areas where beet is grown, in the optimal version - sugar beet, which includes the use of one or more AI 5 inhibitory herbicides belonging to groups (A), (B) and/or (C) , alone or in combination with non-AI 5-inhibiting herbicides belonging to class (0) compounds according to the invention, to plants (e.g. noxious plants such as monocotyledonous or dicotyledonous weeds or unwanted crop plants), seeds (seeds or organs of vegetative reproduction, such as tubers or parts of shoots) or to areas on which plants are grown (e.g. cultivated acreage), for example, together or separately. One or more non-AI5 inhibitory herbicides may be applied in combination with one or more AI5 inhibitory herbicides before, after, or simultaneously with the AI5 inhibitory herbicide(s) to plants, seeds, or areas on which the plants are grown (e.g., cultivated of cultivated areas). "Unwanted plants" or "undesirable vegetation" should be understood as all plants growing in places where they are undesirable. They can be, for example, harmful plants (for example, monocotyledonous or dicotyledonous weeds or unwanted cultivated plants).

The herbicidal combinations intended for use according to the invention can be obtained using known processes, for example, in the form of mixed compositions of individual components, if necessary - with other active compounds, impurities and/or customary auxiliaries for formulation, and these combinations are used conventionally by diluting with water or in the form of tank mixtures with joint dilution of components separately or partially separately formulated with water. Fractional application of 60 separately or partially separately prescribed individual components is also possible.

It is also possible to apply inhibiting AI5 herbicides or a combination that includes inhibiting (A5 herbicides) and non-inhibiting AI5 herbicide(s), in many portions (sequential application) using, for example, pre-emergence application followed by post-emergence applications or with using early post-emergence application followed by medium or late post-emergence application. At the same time, preference is given to joint or almost simultaneous administration of the active compounds of this combination.

The herbicides which belong to any of the above defined groups (A), (B), (C) and (0) and which are to be applied according to the present invention can be converted together or separately into conventional compositions such as solutions , emulsions, suspensions, powders, foams, pastes, granules, aerosols, natural and synthetic materials impregnated with an active compound, and microencapsulation in polymeric materials. The compositions may include conventional excipients and additives.

These compositions are produced in a known manner, for example, by mixing active compounds with fillers, that is, liquid solvents, compressed liquefied gases and/or solid carriers, in appropriate cases - with the use of surface-active substances, that is, emulsifiers and/or dispersants and/ or foaming agents.

If the used filler is water, it is also possible to use, for example, organic solvents as additional solvents. Acceptable liquid solvents are mainly: aromatic compounds such as xylene, toluene, alkylnaphthalenes, chlorinated aromatic compounds or chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, e.g. mineral oil fractions, mineral and vegetable oils, alcohols such as butanol or glycol and their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, highly polar solvents such as dimethylformamide or dimethyl sulfoxide, and water.

Acceptable solid carriers are, for example, ammonium salts and natural earth minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomite, and earth synthetic minerals such as fine silica, alumina and silicates; acceptable solid carriers for the granules are, for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, as well as synthetic granules of inorganic and

From finely ground organic materials and pellets of organic material such as sawdust, coconut shells, corncobs and tobacco stalks; acceptable emulsifiers and/or foaming agents are, for example, nonionic and anionic emulsifiers, such as polyoxyethylene ethers of fatty acids, polyoxyethylene ethers of fatty alcohols, for example, polyglycol alkylaryl ethers, alkyl sulfonates, alkyl sulfates, aryl sulfonates, as well as protein hydrolysates; acceptable dispersants are, for example, lignosulfite spent alkalis and methyl cellulose.

Tackifiers such as carboxymethyl cellulose and natural and synthetic polymers in the form of powders, granules or latexes such as gum arabic, polyvinyl alcohol and polyvinyl acetate and natural phospholipids such as cephalins and lecithins may be used in the compositions, and synthetic phospholipids. Other possible impurities are mineral and vegetable oils.

The herbicidal effect of the herbicidal combinations intended for use according to the invention can be improved, for example, through surface-active substances, in the optimal version - wetting agents from the group of polyglycol ethers of fatty alcohols. Polyglycol ethers of fatty alcohols optimally include 10-18 carbon atoms in the fatty acid radical and 2-20 ethylene oxide units in the polyglycol ether part. Polyglycol ethers of fatty alcohols can be present in nonionic form or in ionic form, for example in the form of sulfates of polyglycol ethers of fatty alcohols, which can be used, for example, as alkali metal salts (eg sodium salts and potassium salts) or ammonium salts, or even as salts alkaline earth metals, such as magnesium salts, such as Si/C14-diglycol ether of fatty alcohol, sodium sulfate (Separo!F I VO, Siagpapi Stn); see, for example, documents EP-A-0476555, EP-

A-0048436, ER-A-0336151 or I5-A-4,400,196, as well as Rhos. EM/BA5 butr. "Rasiogz ANesiipd

Negbisida! Asiimpu apa beiIesiimpu", 227-232 (1988). Nonionic polyglycol ethers of fatty alcohols are, for example, (Sto-Siv)-,) in the optimal version - (C1to-C14)-polyglycol ethers of fatty alcohols (for example, polyglycol ethers of isotridecyl alcohol) , which include, for example, 2-20, in the optimal version - 3-15, ethylene oxide units, for example, from the X-series of Separo!ie, such as Separoie?X-030, Separoie X-060, Separo!?X- 080 or Separoi!? X-150 (all from Siapapi

Surtbn).

The present invention also includes a combination of inhibiting AI 5 herbicides belonging to any of the groups (A), (B) and (C) according to the present invention, with the above-mentioned wetting agents from the group of polyglycol ethers of fatty alcohols, which in the optimal version contain 10-18 carbon atoms in the fatty acid radical and 2-20 ethylene oxide units in the polyglycol ether moiety, and which may be present in nonionic or ionic form (eg, as sulfates of polyglycol ethers of fatty alcohols). Optimal are C:i2/Ci4-diglycol ether of fatty alcohol, sodium sulfate (Separoi? IVO, Siagapi SbtrH) and polyglycol ether of isotridecyl alcohol, which has 3-15 ethylene oxide units, for example, from the X-series

Separoi!e, such as Separoi? X-030, Separoi!? X-060, Separo!? X-080 and Separoi? X-150 (all from

SiIapyapi Str). In addition, polyglycol ethers of fatty alcohols such as nonionic or ionic polyglycol ethers of fatty alcohols (eg, polyglycol ethers of fatty alcohol sulfates) are also known to be suitable for use as penetrants and enhancers for many other herbicides (see, e.g., document ER-A-0502014).

In addition, polyglycol ethers of fatty alcohols such as nonionic or ionic polyglycol ethers of fatty alcohols (e.g. sulfates of polyglycol ethers of fatty alcohols) are also known to be suitable for use as penetrants and enhancers for many other herbicides (see, e.g., ER-A-0502014).

The herbicidal effect of the herbicidal combinations according to the invention can also be enhanced by the use of vegetable oils. The term "vegetable oils" should be understood as plant oils of oily species, such as soybean oil, rapeseed oil, corn oil, sunflower oil, cottonseed oil, linseed oil, coconut oil, palm oil, thistle oil or castor oil, preferably - rapeseed oil, as well as their transesterification products, such as alkyl esters such as rapeseed oil methyl ester or rapeseed oil ethyl ester.

Vegetable oils in the optimal version are esters of Stio-Cgo-, in the optimal version - Si2-Cgo-fatty acids. Esters of C:io-Cg2g2-fatty acids are, for example, esters of unsaturated or saturated C1io-Cgg-fatty acids, in particular, those having an even number of carbon atoms, for example, erucic acid, lauric acid, palmitic acid, in particular,

Fatty acids such as stearic acid, oleic acid, linoleic acid or linolenic acid.

Examples of esters of С10-Сгг-fatty acids are esters obtained by the reaction of glycerol or glycol with Сто-Сге fatty acids, which are contained, for example, in the oils of oleaginous plants,

Zo or C1-C8-alkyl esters of C10-C8-fatty acids, which can be obtained, for example, by transesterification of the above-mentioned glycerol or glycol esters of C0-C8-fatty acids

CO-alcohols (for example, methanol, ethanol, propanol or butanol). The transesterification can be carried out by known methods as described, for example, in the publication of Votre Spetier

I ehikop, Zp yediyop, MoYishte 2, rade 1343, Tniete Mepad Zishodapy.

Optimum C1-C6 alkyl esters of C10-C10 fatty acids are methyl esters, ethyl esters, propyl esters, butyl esters, 2-ethylhexyl esters, and dodecyl esters. Optimum glycol and glycerol esters of Stio-C6 fatty acids are homogeneous or mixed glycol esters and glycerol esters of Stio-C6 fatty acids, in particular, fatty acids having an even number of carbon atoms, for example, erucic acid, lauric acid, palmitic acid, in particular, fatty acids such as stearic acid, oleic acid, linoleic acid or linolenic acid.

In the herbicidal compositions to be used according to the invention, vegetable oils can be present, for example, in the form of oil-containing admixtures for industrial production compositions, in particular, admixtures based on rapeseed oil, such as Naziep? (Misyupap Spetisai!

Sotrapu, Australia, hereinafter referred to as Navziep, main ingredient: rapeseed oil ethyl ester), AsiitoreV (Momapse, France, hereinafter referred to as AsiigovV, main ingredient: rapeseed oil methyl ester), Baco-Vipo!? (Waueg AS, Germany, hereinafter referred to as Nako-Vipoi, main ingredient: rapeseed oil), Nepo!? (5ieiez5, Germany, hereinafter referred to as Vepoi, vegetable oil ingredient: methyl ester of rapeseed oil) or biieiez Mego? (5ieie5, Germany, hereinafter referred to as Mego, main ingredient: rapeseed oil methyl ester).

In another embodiment, the herbicidal combinations to be used according to the present invention can be formulated with the above-mentioned vegetable oils, such as rapeseed oil, preferably in the form of oil-containing admixtures for industrial production compositions, in particular, admixtures based on rapeseed oil , such as Navziep? (Mistopap Spetis! Sotrapu, Australia, hereinafter referred to as Nabviep, main ingredient: rapeseed oil ethyl ester), AsitoreV (Momapse, France, hereinafter referred to as AsiigovBV, main ingredient: rapeseed oil methyl ester), VaCo-Vipoi? (Waueg AS, Germany, hereinafter referred to as NakKo-Vipoi, main ingredient: rapeseed oil), Vepo!? (5ieie5, Germany, hereinafter referred to as Vepoi, vegetable oil ingredient: rapeseed oil methyl ester) or biieie5

Mego? (5ieie5z, Germany, hereinafter referred to as Mego, main ingredient: rapeseed oil methyl ester).

It is possible to use dyes, such as inorganic pigments, for example, iron oxide, titanium oxide, Berlin azure, and organic dyes, such as alizarin pigments, azo dyes, and metallophthalocyanine dyes, and trace elements, such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

The compositions to be used according to the present invention usually include from 0.1 to 95% by weight of active compounds, preferably from 0.5 to 90% by weight.

Individually or as part of compositions, AI 5-inhibiting herbicides belonging to any of the above groups (A), (B) and (C) can also be used as a mixture with other agrochemically active compounds, such as known non-AI 5-inhibiting ones herbicides, for the control of unwanted vegetation, for example, for the control of weeds or for the control of unwanted cultivated plants, and ready compositions or tank mixes are possible, for example.

It is also possible to use a mixture of AI-5 inhibiting herbicides belonging to any of the above groups (A), (B) and (C) with other known active compounds, such as fungicides, insecticides, acaricides, nematicides, antidotes , bird repellants, plant nutrients and soil structure improvers.

Inhibiting A 5 herbicides, which belong to any of the above groups (A), (B), (C), can be used separately, in the form of their compositions or in forms of application obtained from them by additional dilution, such as ready for use solutions, suspensions, emulsions, powders, pastes and granules. Application is carried out in a traditional way, for example, by watering, sprinkling, spraying, scattering.

According to the invention, one or more AI 5-inhibiting herbicides belonging to any of the above groups (A), (B) and (C) can be used alone or in combination with one or more non-AI 5-inhibiting herbicides that belonging to group (0), to plants (e.g. noxious plants such as monocotyledonous or dicotyledonous weeds or unwanted crop plants), seeds (e.g. grains, seeds or vegetative reproductive organs such as tubers or parts of shoots with buds ) or cultivated cultivated areas (for example, soil), in the optimal version - to green plants and parts of plants, and, in appropriate cases, additionally to soil. An example of a possible application is the joint application of active compounds in the form of tank mixtures, in which optimally formulated concentrated compositions of individual active compounds are mixed in a tank with water and the liquid obtained in this way is introduced for spraying.

Biological examples

Selection for obtaining tolerant to AII inhibitor 5 beetroot plants

The production, selection and distribution of suitable AI5-inhibiting herbicide-tolerant mutants of common beet and their progeny, to be used in all the biological examples described below, is described in detail in a submission to the European Patent Office

The European patent application in electronic form dated 10.15.2010 entitled "Tolerant to AI 5 herbicide-inhibiting mutants of common beet", the co-applicant of which is Vaujeg Storbsiepse da, and which received the number EP10187751.2, and in the PCT application EP10187751.2 is declared as a priority application.

Thus, these relevant methods relating to the production of such AI 5 inhibitory herbicide tolerant mutants of common beet, in particular sugar beet mutants that include a mutation at position 569 of AI 5, which is encoded by the endogenous AI5 gene, are described in this specification only in general terms , and the contents, in particular, of Examples 1 through 5 of the above patent application are incorporated by reference in their entirety.

Sugar beet cell cultures were obtained from sugar beet seedlings of the diploid genotype 779044 (which is described, for example, in the publications of Aiekhapayeg Oom2pepKo, RO TNeviv,

That: "Tomzhagaz riavyi igapetoptatsyop ip garezeea (Vgavvisa paris I.) apa zida!beei (Veia miyiYidagib

GU, Sodm/id-Mahitiyap5-Opimegtvznyai Mipsnep, Septapu, 2001).

The callus obtained from them was exposed to 107 M of foramsulfuron.

Colonies of cells that survived and grew were numbered and transferred after 4-6 weeks to fresh medium containing 3x10-M inhibitor. One of these cell colonies was able to grow not only at this concentration of the inhibitor, but also in the presence of 3x106 M of foramsulfuron |(СА5 ВМ 173159-57-4).

Shoots were regenerated from this clone (5857411) in the presence of the AI 5 inhibitory herbicide, and then the shoots were transferred to Mo medium containing 0.05 mg/l naphthalene acetic acid (MAA).

During the first 10-15 days after transfer to the soil containing the substrate, the plants were kept in an environment with high air humidity. During and after their transfer to the mode of normal greenhouse air humidity, the plants were kept in a greenhouse under artificial light (12 hours) at 20 4-3 "C/154-2 "C day/night temperature.

After 3-5 weeks, regenerated plants from previously prepared foramsulfuron-tolerant cell culture (58574T1), as well as from wild-type cell cultures, were treated with foramsulfuron, iodosulfuron-methyl-sodium (СА ВМ 144550-3-7) and a mixture of both active ingredients. The tested herbicide doses were equivalent to 7-70 g a.i/ha for foramsulfuron and 1-10 g a.i/ha for iodosulfuron-methyl-sodium.

Regenerated plants from this tolerant cell line tolerated even the highest doses of herbicides (foramsulfuron, iodosulfuron-methyl-sodium, and their 7:1 mixtures), whereas wild-type plants died even at the lowest doses.

Homozygous seedlings withstood mixtures of 35 g of foramsulfuron/ha and 7 g of iodosulfuron-methyl-sodium/ha without growth retardation or any signs of visible damage. In a few cases, heterozygous lines at this amount showed signs of stunted growth and some leaf chlorosis, but they recovered in 3-5 weeks, whereas normal sugar beet seedlings died from AI-inhibiting 5 herbicides.

The obtained seed contained a mutation with the substitution of tryptophan for leucine at position 569 of the protein

AII 5, encoded by the endogenous AII5 gene of sugar beet (based on 5857411), was deposited in the National Collection of Industrial, Food and Marine Bacteria,

Aregdeep, Great Britain, under the number МСИМВ 41705, with Vaujeg Storbsiepse AS acting as co-depositor.

Added sequences (EC IO MO from 1 to 4)

The added sequence of 5EO IYUO Mo 1 represents the nucleic acid sequence of wild type sugar beet genotype 719044; 5EO IU MO 2 represents the AI 5 protein that is encoded

ZEO IU Mo 1; 5EO IO Mo Z represents the obtained mutated AI 5 gene of the sugar beet mutant line "585741", ii BEO IO Mo 4 represents Tr -» I e and mutated AI 5 protein at position 569, which is encoded by the nucleic acid sequence described under 5EO IUO Mo 3, and which is present in the endogenous АЙ5 gene 58574ТИ, which was deposited under the number МСИМВ 41705 in the МСИМВ,

From Aregadeep, United Kingdom. 2. Field trials with the use of homozygous tolerant to AI5 inhibitory herbicides of sugar beet plants

On the basis of 585741. E4-Eb seeds, which provide a mutant allele of the endogenous AI 5 gene in a homozygous state, were used for further testing.

Seeds of homozygous mutant plants 58574TY and seeds of traditional varieties KI AVIMA and

VEVETTA (both publicly available control varieties of sugar beet sensitive to the AI 5 inhibitor did not have the corresponding mutation at position 569 in the AI 5 protein) were sown in the field and grown to different stages of growth according to the standard of the Russian Academy of Sciences (defined in the monograph "KEpimiskiipd55iadiep. topo-ypa aikoiuiieeg RPapgep ", 2pa eaiiop, 2001, sa. Shiue Meiieg, Vioiodizspe Vypaezapviai! Tig apa ipa

Eogzym/invspai).

The plants were then treated with the respective AI5 inhibitory herbicides as shown in Tables 1, 2 and 3 below.

The amount of water used in different cases was equal to 200 l/ha.

After 8, 14, 16, 17, 28 and 31 days (as indicated in the various Tables) after application (OAA) of the respective inhibitor(s) A! The damage (phytotoxicity/phyto) of 5 herbicide(s) to different sugar beet plants was determined on a scale from 0 95 to 100 95.

In this context, "0 95" means "no phytotoxicity/phyto" and "100 90" means that the plants have died completely.

The obtained results are presented in detail below in Tables 1, 2 and 3.

Table 1

Sugar beet based

VVSN 14 | VVSN 14 | VVSN 14 | VVSN 14 | VVSN 14 | VVSN 14

Deposit Interval - Assessment VrAA 17ОАА | 31 BAA VrAA 17OAA | 31 SAA o Aktivnarechovyna (gaila | 777111

Foramsulfuron (A1- 25 13) yaz- Thiencarbazone- 15 83 95 100 methyl (A2-3

Foramsulfuron (A1- BO 13) yaz- Thiencarbazone- 30 85 100 methyl (A2-3

Compound (A1-87 30 | o | 0 | 0 | 83 | l00 | to

Iodosulfuron-methyl-sodium (1-16 15 83 100

According to the data presented in Table 1, it was clearly demonstrated that the sugar beet plants based on 58574TI are fully tolerant to the application of various inhibitors

A 5 herbicides, i.e., with the separate application of an inhibiting A 5 herbicide, as well as with the combined application of two different Ai/5 inhibitory herbicides (foramsulfuron and tencarbacon-methyl), which belong to two different subgroups (A1 and (A2)) of the group ( A), i.e., (sulfon)amides, while the traditional variety KI AVIMA suffers significant damage under identical growing conditions.

Table 2

Sugar Sugar Sugar

Characteristics of the KIAVIMA variety beet on dvmd beet on dvmd|beet on the basis of the basis of the basis

ZV574TI. ZV574TI. ZV574TI. (Etapvnesia.i 00000000 IVVSNI4|VVSNI4 |VVSNI14 |vvSN 14 |VVSN 14 | VVSN 14

Application Interval - Evaluation of Active Substance 0 Yigaila | 77777771

Foramsulfuron (A!-13) | 25 g/a | 85 | 0 | 83 | 0 | 86 | o0

Foramsulfuron (AT-13) | 50 gla | 90 | 0 1 92 | 0 | 94 | 0

Thiencarbazone-methyl (A2-3) / 15 g/a | 90 | 0 1 97 | 0 | 700 | o0

Thiencarbazone-methyl(A2-3) / ЗОг/а | 90 | 0 1 97 | 0 | 700 | o0

A1-13) same (D2-3 25-15p/a| 90 | 0 | 97 | 0 | 700 | o0 (A1-13) same (D2-3 50o-30gla| 90 | z | 97 | 0 | 700 | o0 dir tav | yu | o | v | o | mo o

Compound (AT-87 l15a | 90 | 0 1 97 | 0 | 99 | 0

Compound (A1-41 Ash | 90 | 14 | 98 | 0 | l00 | 0 17

Metsulfuron-methyl (AT-18)| 8 g/la 88 | 14 | 98 | 6 | 99 | 0 ( blow St

Nicosulfuron (A1-20 god | 90 | 0 | 98 | 0 | 7100 | o0

Tribenuron-methyl (AT-31) / ZbOg/a | 91 | 10 | 98 | 1 | 7100 | o0

Rimsulfuron (A1-26 and 25gla | 81 | 0 | 85 | 4 | 76 | 0

Sodium bispyribac (C1-1 God | 90 | 23 | 98 | 30 | 99 | 0

Methosulam (AZ-5 Zola | 90 | 9 | 97 | 0 | 9 | 0

Imazamox (В1-2 И 4огла | 90 | 0 | 97 | 0 | 99 | 0 /

According to the data presented in Table 2, it was clearly demonstrated that the sugar beet plants based on 58574TI are fully tolerant to the application of various inhibitors

AII 5 herbicides, i.e., tolerance to the presented compounds selected from all 3 different groups (A), (B) and (C)) was demonstrated, while the traditional KI variety AVIMA suffers significant damage under identical growing conditions.

Table C

Sugar Sugar Sugar

Characteristics of the variety VEVETTA OURYAK On VEVETTAd beet on derdrttd beet on the basis on the basis on the basis

ZV574TI. Z8V574TI. Z8V574TI.

Active substance 0 |gaila| 77777771 preons are He 15 er "Triasulfuron(AT-30) |ZOgla| 80 | 0 | 98 | 0 | tl00 | o / (Chlorsulfuron(A1-5) |20g/a| 80 | 0 | 98 | 0 | tl00 | about /

Flupirsulone-methyl-

But nya Kl. NISSNVI NSTNY MOSS NOSTONY NOESNNY INN

Prosulfuron (A1-24) |40g/la| 81 | 21 | 98 | 30 | tl00 | o / (Tritosulfuron (A1-34) | 5Og/a | 80 | 20 | 98 | 33 | tl00 | 5 /

Flazasulfuron (AT-10)|5Og/la| 80 | 24 | 98 | 25 | l100 | p" peneyu sht yu | 15715

Omazetapir (B1-6) |70 gl| 80 | 0 | 98 | 0 | l00 | o / mazapir (B1-4) | гбгла| 80 | 0 | 98 | 0 | l00 | about / mazapikvi-3) | 70 gl| 80 | 14 | 98 | 0 | tl00 | o / mazakhin (B1-5) About g/lai 80 | 0 | 98 | 0 | l00 | about /

Florasulam (AZ3-3) |iOgla| 80 | 0 | 98 | 0 | 98 | about /

Penoxsulam (AZ-6) |40g/la| 80 | 0 | 91 | 15 | 700 | about /

Flumetsulam (AZ-4) |50g/la| 80 | 0 | 98 | 0 | tl00 | about /

Pyroxsulam (AZ-7) |50g/la| 80 | 0 | 97 | 0 | l00 | O children, I eat you g yuju 4 g/ha

Trifloxysul on- charge it in | ov | about | at

According to the data presented in Table 3, it was clearly demonstrated that the sugar beet plants on the basis of 58574TI are fully tolerant to the introduction of various inhibitors

AII 5 herbicides, i.e. tolerance to the presented compounds selected from both different groups (A) and (B)) was demonstrated, while the traditional variety VEVETTA suffers significant damage under identical conditions.

LIST OF SEQUENCES

"110" VAYER INTELLEKCHUEEL PROPERTY GMBH "120" Application of AI 5-inhibiting herbicides to combat unwanted vegetation on areas of cultivation of common beet tolerant to AI 5-inhibiting herbicides -1305"5 ВС5 09-1020 -160" 4 "170" Raiepiip version 3.3 " 2105 1 "-2115 1998 "212" DNA "213" Veia myYidagov "4005 1 pe tutu ep I umi MIVOiY ro teh IH M pr LIVO photo m ily it kim EI VO sguluttettti M Myh IO i IK nn m v o p M V t o NN I WRITE ME NOT TATIZHTO MO "TWA TKI MM HIM MU mer ko nn i Not in No o ulug lush FOR AGES La WE inU pili Timy pla p ma g pit tiru zho ikshuzii yuyu griti in there Mk shh gpitett arrival tetu EK hatu

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Claims (8)

FORMULA OF THE INVENTION 1. Application of one or more AI 5 inhibiting herbicides selected from the group consisting of: chlorsulfuron |(СА5 VAM 64902-72-3| (- A1-5); flazulfuron |(SAZ EM 104040-78-0) ( - A1-10); flupyrsulfuron-methyl-sodium |(ISA5 KM 144740-54-5) (5 A1-12); foramsulfuron |(SAZ EM 173159-57-4| (- A1-13); iodosulfuron-methyl- sodium (СА KM 144550-36-7| (5 A1-16); mesosulfuron-methyl |ИСА5 KM 208465-21-81) (- A1-17); metsulfuron-methyl |ИСА5 KM 74223-64-6) (- A1-18); nicosulfuron |(SAZ EM 111991-09-4| (- A1-20); prosulfuron |ISA5 EM 94125-34-5I (- A1-24); rimsulfuron |СА5 KM 122931-48-0| ( - A1-26); sulfometuron-methyl |ISA5 KM 74222-97-2) (x A1-27); sulfosulfuron |(SAZ EM 141776-32-1) (- A1-28); thifensulfuron-methyl |(СА5 KM 79277-27-3) (5 A1-29); triasulfuron | (SAZ KM 82097-50-5) (- A1-30); tribenuron-methyl | ISAZ EM 101200-48-0) (- A1-31); trifloxysulfuron |ISA5 KM 145099-21-4| (sodium) (- A1-32); tritosulfuron |CA5 EM 142469-14-5) (- A1-34); compound of the general formula (I) I in МН вери M сн, В и оо о Осн, () where M" means sodium (- A1-41); compound of formula (II) (- A1-87), schu; bom (c) Z r N z tn po ma D 4 M EI AS Osn» OSA (c) Zo flucarbazone-sodium (SA KM 181274-17-9 | (- A2-1); propoxycarbazone-sodium (SA EM 181274- 15-7| (- A2-2); thiencarbazone-methyl |ISAZ EM 317815-83-1|) (- A2-3); florasulam (SAZ EM 145701-23-1| (- AZ-3); flumetsulam | ISA5 EM 98967-40-91I (- AZ-4); methosulam |ISA5 EM 139528-85-11| (- AZ-5); penoxsulam (SAZ KM 219714-96-21 (- AZ-6); piroxsulam |( SAZ EM 422556-08-9| (- AZ-7); imazamox (СА5 KM 114311-32-9| (- B1-2); imazapic (SAZ EM 104098-48-8) (- B1-3); imazapyr (ISA5 KM 81334-34-11 (- B1-4); imazaquin (SAZ EM 81335-37-7| (- B1-5); imazetapir (SA KM 81335-77-5| (- B1-6) and bispyribac-sodium (СА5 ЕМ 125401-92-5| (- С1-1) for the control of unwanted vegetation in the fields of cultivation of common beet, and the plants of common beet include a mutation in codon 1705-1707 of the endogenous gene AI 5, which encodes the protein AG 5 , which contains an amino acid other than tryptophan at position 569, and the corresponding mutation is homozygously present. 2. Use of one or more AI 5 inhibiting herbicides according to claim 1, which is characterized by the fact that the AI 5 inhibiting herbicide(s) is a combination of foramsulfuron |(СА5 EM 173159-57-4| (- A1-13) and thiencarbazone -methyl (ISAZ EM 317815-83-1) (- A2-3). 3. The use of one or more inhibiting AG 5 herbicides according to claim 1 or 2, which differs in that the amino acid of the AI 5 protein at position 569 is leucine. 4. Use of one or more AI 5-inhibiting herbicides according to any of claims 1-3 in combination with non-AG 5-inhibiting herbicides (that is, herbicides that demonstrate a mechanism of action other than inhibiting the enzyme AG 5|acetohydroxyacid synthase; ES 2.2. 1.6) herbicides of group 0), and non-inhibiting A. 5 herbicide(s) is selected from the group that includes: chloridazon, clethodim, clodinafop, clodinafop-propargyl, clopyralid, cycloxidim, desmedifam, dimethenamid, dimethenamid-R, etofumesate, fenoxaprop, fenoxaprop-R, fenoxaprop-ethyl, fenoxaprop-R-ethyl, fluazifop, fluazifop-R, fluazifop-butyl, fluazifop-R-butyl, glufosinate, glufosinate-ammonium, glufosinate-R, glufosinate- P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammonium, haloxyfop, haloxyfop-P, haloxyfop-ethoxyethyl, haloxyfop-P-ethoxyethyl, haloxyfop-methyl, haloxyfop-P-methyl, lenacil, metamitron, phenmedipham, phenmedipham- ethyl, propaquizafop, hinmerac, hizalofop, hizalofop-ethyl, hizalofop-R, hizalofop-R-ethyl, hizal ofop-P-tefuryl, sethoxydim. 5. Use of one or more AI 5-inhibiting herbicides according to claim 4, which is characterized by the fact that the non-AI 5-inhibiting herbicide(s) are selected from the group that includes: desmedifam, etofumesate, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-P-sodium, glyphosate, glyphosate-isopropylammonium, lenacil, metamitron, Zo phenmedipham, phenmedipham-ethyl. 6. The method of combating unwanted vegetation on the areas of beet cultivation, which includes the treatment of unwanted vegetation with one or more AI 5 inhibitory herbicides selected from the group consisting of: chlorsulfuron (SAZ EM 64902-72-3) (- A1-5 ); Flazasulfuron | (SAZ EM 104040-78-0) (- A1-10); flupyrsulfuron-methyl-sodium (ISA5 KM 144740-54-5) (5 A1-12); foramsulfuron |(SAZ EM 173159-57-4| (- A1-13); iodosulfuron-methyl-sodium (СА KM 144550-36-7| (5 A1-16); mesosulfuron-methyl |ИСА5 KM 208465-21-81 ) (- A1-17); metsulfuron-methyl |ICA5 KM 74223-64-6) (- A1-18); nicosulfuron |(SAZ EM 111991-09-4| (- A1-20); prosulfuron |ISA5 EM 94125-34-5I (- A1-24); rimsulfuron |СА5 KM 122931-48-0| (- A1-26) sulfometuron-methyl |ICA5 KM 74222-97-2) (- A1-27); sulfosulfuron (SAZ EM 141776-32-1) (- A1-28); Thifensulfuron-methyl (CA5 KM 79277-27-3) (5 A1-29); triasulfuron (SAZ KM 82097-50-5) (- A1-30); tribenuron-methyl (CA5 VM 101200-48-0) (- A1-31); trifloxysulfuron |ISA5 KM 145099-21-4| (sodium) (5 A1-32); tritosulfuron (SAZ EM 142469-14-5) (- A1-34); compound of the general formula (I) Coll And in M H var M sn, and T Io, oo o Osn, (and where M" means sodium (- A1-41); the compound of formula (II) (- A1-87), which bom her (c) 5 (1) flucarbazone-sodium (SA KM 181274-17-9| (- A2-1); propoxycarbazone-sodium (SA EM 181274-15-7 | (- A2-2); thiencarbazone-methyl |CA5 KM 317815-83-1| (- A2-3); florasulam (SAZ EM 145701-23-1| (- AZ-3); flumetsulam |ISA5 KM 98967- 40-91| (- AZ-4); methosulam |ISA5 EM 139528-85-11| (- AZ-5); penoxsulam |(SAZ KM 219714-96-21 (- AZ-6); piroxsulam |(SAZ EM (- AZ-7); ISA5 KM 81334-34-11 (- B1-4); imazaquin (SAZ EM 81335-37-7| (- B1-5); imazetapyr (SA KM 81335-77-5| (- B1-6) and bispiribac- sodium (СА5 ЕМ 125401-92-5| (- С1-1), alone or in combination with one or more herbicides that do not belong to the class AI 5 inhibitory herbicides (herbicides that do not inhibit AI 5), which differs in that that processing is carried out in the presence of beet plants with unusual, which include a mutation in codon 1705-1707 of the endogenous AI5Z gene, which encodes the AI5 protein, which contains an amino acid other than tryptophan at position 569, and the corresponding mutation is homozygously present, and where the use of the specified herbicide(s) occurs together or at the same time, or (i) occurs at different times and/or in many portions (sequential application), in pre-emergence application followed by post-emergence applications or early post-emergence application followed by mid- or late post-emergence application. 7. The method of combating unwanted vegetation according to claim 6, which differs in that the AI 5 inhibitory herbicide(s) is a combination of foramsulfuron (SAZ KM 173159-57-4) (- A1-13) and thiencarbazone-methyl |ISA5 EM 317815-83-1| (- A2-3). 8. The method according to item b or 7, which differs in that non-inhibiting A! The herbicide(s) are selected from the group consisting of: chloridazone, clethodim, clodinafop, clodinafop-propargyl, clopyralid, cycloxidim, desmedifam, dimethenamid, dimethenamid-R, etofumesate, fenoxaprop, fenoxaprop-R, fenoxaprop-ethyl, fenoxaprop -P-ethyl, fluazifop, fluazifop-P, fluazifop-butyl, fluazifop-P-butyl, glufosinate, glufosinate-ammonium, glufosinate-P, glufosinate-P-ammonium, glufosinate-R-sodium, glyphosate, glyphosate-isopropylammonium, haloxyfop, haloxyfop-R, haloxyfop-ethoxyethyl, haloxyfop-R-ethoxyethyl, haloxyfop-methyl, haloxyfop-R-methyl, lenacil, metamitron, phenmedipham, phenmedipham-ethyl, propaquizafop, Khinmerak, Khizalofop, Khizalofop-ethyl, Khizalofop-P, Khizalofop-P-ethyl, Khizalofop-P-tefuryl, Sethoxydim.