UA121250U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

Diagnostic method for the development of atherosclerosis includes clinical examination, studies of low and high density lipoprotein cholesterol levels, arteriography, determination of MTHFR C677T gene polymorphism in serum, thrombomodulin content, folic acid, pyridinolin, SR. With homozygous carrier 677-TT, thrombomodulin levels> 5 ng / ml, folic acid <6 ng / ml, pyridinoline> 8 ng / ml, SRP> 6 mg / l, homocysteine> 20 μmol / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov.

Diagnosis of diseases of internal organs. - Vol. 6 - pp. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high density lipoprotein cholesterol levels, the polymorphism of the methylenetetrahydrofolate reductase gene (MTNEV C677T), the content of thrombomodulin, folic acid, pyridinoline, C-reactive protein (CRP), homocysteine is determined in the patient's blood serum by arteriography. At homozygous carrier 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, pyridinoline "8 ng/ml, SRP "6b mg/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.

Application of the method. During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. In the blood serum of the patient, the MTNEV C677T gene polymorphism is determined. The content of thrombomodulin, folic acid, pyridinoline, SRP, homocysteine is determined by immunoenzymatic method. At a homozygous carrier of 677-TT, levels of thrombomodulin "5 ng/ml, folic acid "6 ng/ml, pyridinoline "8 ng/ml, SRP "6 mg/l, homocysteine 220 μmol/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient K., 46 years old, was hospitalized with a diagnosis of rheumatoid arthritis. Inspected.

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. The MTNEV gene polymorphism was determined in blood serum

Сб677Т. The content of thrombomodulin, folic acid,

From pyridinoline, SRP, homocysteine. Homozygous carrier 677-1T was established. Levels of thrombomodulin - 8.8 ng/ml, folic acid - 4 ng/ml, pyridinoline - 21 ng/ml, SRP - 19 mg/l, homocysteine - 28 μmol/l. The development of atherosclerosis was diagnosed. Arteriographic signs of atherosclerosis were established only after 13 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, level research 40 cholesterol of low and high density lipoproteins, arteriography, which is distinguished by the fact that the MTNEV Sb677T gene polymorphism, the content of thrombomodulin, folic acid, pyridinoline, SRP, homocysteine are additionally determined in the blood serum, and in the case of homozygous carrier 677-TT, levels of thrombomodulin »5 ng /ml, folic acid "6 ng/ml, pyridinoline "8 ng/ml, SRP "6 mg/l, homocysteine 220 μmol/l diagnose the development of atherosclerosis.