UA121069U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

Diagnostic method for the development of atherosclerosis, including clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography, determination of MTHFR C677T, eNOS T786C gene polymorphism in serum, TFR-β1, homocysteine, homocysteine 677-TT, 786-CC, TGF-β1 levels <14 ng / ml, homocysteine> 20 μmol / l, IL-6> 10 ng / l, SRP> 6 mg / l diagnose the development of atherosclerosis.

Description

The proposed method of diagnosing the development of atherosclerosis belongs to medicine, in particular to therapy and rheumatology. It is prescribed and can be used in the treatment and examination of patients.

Ways of diagnosing the development of atherosclerosis are known. These include determination of cholesterol levels of low and high density lipoproteins, arteriography of Ts|A.N. Okorokov

Diagnosis of diseases of internal organs. -T. 6-S. 75-85).

However, the known method is not effective enough and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by the fact that along with the study of low and high-density lipoprotein cholesterol levels, arteriography in the patient's blood serum determines the polymorphism of the genes methylenetetrahydrofolate reductase (MINEK C677T), nitric oxide synthase (emoz T786C), the content of transforming growth factor beta 1 (TGF-DVI) , homocysteine, interleukin 6 (IL-6), C-reactive protein (CRP). With homozygous carrier 677-1T, 786-

SS, levels of TFR-VDI "14 ng/ml, homocysteine 220 μmol/l, IL-b6 "10 ng/l, SRP 56 mg/l diagnose the development of atherosclerosis.

Application of the method. Upon admission, the patient is examined, low-density lipoprotein and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Polymorphisms of MITNEK C677T, eMmOo5z T786C genes are determined in blood serum, the content of TGF-R1, homocysteine, IL-6, SRP by immunoenzymatic method. At a homozygous carrier of 677-TT, 786-SS, levels of TFR-DV1-"14 ng/ml, homocysteine 220 μmol/l, IL-6 210 ng/l, SRP "6 mg/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient M., 56 years old, was hospitalized in the clinic with a diagnosis of rheumatoid arthritis.

Examined Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. Polymorphisms of MITNEK C677T and emo5 T786C genes were determined in blood serum. The content of TFR-(31, homocysteine, IL-6, SRP) was determined by the immunoenzymatic method. Homozygous carriers of 677-TT and 786-SS were established. TFR-D1 levels - 9.2 ng/ml, homocysteine - 28 μmol/l, IL-6 -17.8 ng/l, PSA - 14 mg/l. The development of atherosclerosis was diagnosed. Arteriographic signs of the latter were detected only after 12 months.

Thus, the proposed method allows diagnosing atherosclerosis in the early stages of the process.

Claims (1)

USEFUL MODEL FORMULA The method of diagnosing the development of atherosclerosis, which includes a clinical examination, the study of low and high-density lipoprotein cholesterol levels, arteriography, the determination of polymorphisms of the MITNEV C677tT, emMOo5 T786C genes, the content of TFR-DV1, homocysteine, IL-6, SRP in blood serum, which differs in that with homozygous carriers of 677-TT, 786-SS, levels of TFR-D1 -14 ng/ml, homocysteine 220 μmol/l, IL-6 »10 ng/l, SRP »b mg/l, the development of atherosclerosis is diagnosed .