UA120222U - METHOD OF DIAGNOSTICS OF ATHEROSCLEROSIS DEVELOPMENT - Google Patents

Abstract

A method of diagnosing the development of atherosclerosis includes clinical examination, examination of low and high density lipoprotein cholesterol levels, arteriography. In the serum determine the polymorphism of the genes MTHFR C677T, eNOS T786C, the content of thrombomodulin, CISR, homocysteine, PSA, IL-6. When homozygous carrier 677-TT, 786-CC, thrombomodulin levels> 5 ng / ml, CISR <102 ng / ml, homocysteine> 20 μmol / l, SRP> 6 mg / l, IL-6> 10 ng / l diagnose the development atherosclerosis.

Description

The useful model belongs to the field of medicine, in particular to therapy and rheumatology, and is intended and can be used in the treatment and examination of patients.

A well-known analogue is the method of determining low- and high-density lipoprotein cholesterol levels, arteriography (AN Okorokov. Diagnostics of diseases of internal organs. - Vol. 6 - pp. 75-85).

However, the analogue is insufficiently effective and does not allow diagnosing the development of atherosclerosis even at the onset of the disease. Accordingly, there is no possibility to prevent atherosclerosis.

The basis of a useful model is the task of developing a method that would allow diagnosing the onset of atherosclerosis at an early stage.

The task is solved by conducting a clinical examination with a study of low and high-density lipoprotein cholesterol levels, arteriography, according to a useful model, in the patient's blood serum, the polymorphism of the genes of methylenetetrahydrofolate reductase (MTNEK C677T), nitric oxide synthase (6ЕМО5 T7860С), the content of thrombomodulin, C-terminal propeptide of type I collagen (SICP), homocysteine, C-reactive protein (CRP), interleukin b (IL-b6). With homozygous carrier 6677-17, 786-SS, levels of thrombomodulin "5 ng/ml, SICR "102 ng/ml, homocysteine 220 μmol/l, SRP "b mg/l, IL-6 510 ng/l diagnose the development of atherosclerosis.

A useful model is performed as follows.

During hospitalization, the patient is examined, low- and high-density lipoprotein cholesterol levels are examined, and arteriography is performed. Gene polymorphisms are determined in blood serum

MTNEK S677T, emMmoO5 T786S, the content of thrombomodulin, SISR, homocysteine, SRP, IL-6 by immunoenzymatic method. With homozygous carriers of 677-TT, 786-SS, levels of thrombomodulin "5 ng/ml, SSRI "102 ng/ml, homocysteine 220 μmol/l, SRP 26 mg/l, IL-6 "10 ng/l, the development of atherosclerosis is diagnosed.

A specific example of using the method.

Patient 0., 45 years old, was hospitalized for rheumatoid arthritis. Examined

Low and high density lipoprotein cholesterol levels were studied. An arteriography of vessels was performed. There are no signs of atherosclerosis. Polymorphism of MTNEK genes was determined in blood serum

From S677T and emoz T786S. The content of thrombomodulin, SISR, homocysteine, SRP, IL-b6 was determined by immunoenzymatic method. Homozygous carriers of 677-TT and 786-SS were established. Levels of thrombomodulin - 12.4 ng/ml, SICP - 86 ng/ml, homocysteine - 32 μmol/l, SRP - 17 mg/l, IL-6 - 18.9 ng/l. The development of atherosclerosis was diagnosed. Arteriographic confirmation of the diagnosis was obtained after 8 months.

Thus, a useful model is informative and allows diagnosing the development of atherosclerosis at an early stage.

Claims (1)

USEFUL MODEL FORMULA 40 The method of diagnosing the development of atherosclerosis, which includes a clinical examination, research on the levels of low- and high-density lipoprotein cholesterol, arteriography, which is distinguished by the fact that the polymorphism of the MTNEV C677T, eMO5 1786C genes, the content of thrombomodulin, SISR, homocysteine, SRP, IL- b6, with homozygous carrier 677-1T, 786-СС, thrombomodulin levels "5 ng/ml, SSRI "102 ng/ml, homocysteine 220 μmol/l, SRP "6 mg/l, IL-6 45,210 ng/l diagnose the development of atherosclerosis.