UA113991C2 - 1- (1-methyl-1H-pyrazol-4-yl) -N - ((1R, 5S, 7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] -NONAN-7-yl) -1H-INDOL-3-CARBOXAMID AS A 5-HT3 RECEPTOR ANTAGONIST - Google Patents

1- (1-methyl-1H-pyrazol-4-yl) -N - ((1R, 5S, 7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] -NONAN-7-yl) -1H-INDOL-3-CARBOXAMID AS A 5-HT3 RECEPTOR ANTAGONIST

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Publication number
UA113991C2
UA113991C2 UAA201500605A UAA201500605A UA113991C2 UA 113991 C2 UA113991 C2 UA 113991C2 UA A201500605 A UAA201500605 A UA A201500605A UA A201500605 A UAA201500605 A UA A201500605A UA 113991 C2 UA113991 C2 UA 113991C2
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UA
Ukraine
Prior art keywords
methyl
nonan
azabicyclo
pyrazol
oxa
Prior art date
Application number
UAA201500605A
Other languages
Ukrainian (uk)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2013/050746 external-priority patent/WO2014014951A1/en
Publication of UA113991C2 publication Critical patent/UA113991C2/en

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Abstract

Даний винахід забезпечує антагоністи 5-НТЗ рецептора формули (І):, (I)зокрема 1-(1-метил-1H-піразол-4-іл)-N-((1R,5S,7S)-9-метил-3-окса-9-азабіцикло[3.3.1]-нонан-7-іл)-1H-індол-3-карбоксамід, для лікування захворювань, таких як блювання, біль, зловживання лікарськими засобами, нейродегенеративні й психіатричні розлади, і розлади шлунково-кишкового тракту. Також забезпечуються фармацевтичні композиції, які містять такі сполуки, і способи одержання таких сполук.The present invention provides 5-HTZ receptor antagonists of formula (I) :, (I) in particular 1- (1-methyl-1H-pyrazol-4-yl) -N - ((1R, 5S, 7S) -9-methyl-3 -oxa-9-azabicyclo [3.3.1] -nonan-7-yl) -1H-indole-3-carboxamide, for the treatment of diseases such as vomiting, pain, drug abuse, neurodegenerative and psychiatric disorders, and gastrointestinal disorders; of the intestinal tract. Also provided are pharmaceutical compositions containing such compounds and methods for preparing such compounds.

UAA201500605A 2012-07-17 2013-07-16 1- (1-methyl-1H-pyrazol-4-yl) -N - ((1R, 5S, 7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] -NONAN-7-yl) -1H-INDOL-3-CARBOXAMID AS A 5-HT3 RECEPTOR ANTAGONIST UA113991C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261672709P 2012-07-17 2012-07-17
PCT/US2013/050746 WO2014014951A1 (en) 2012-07-17 2013-07-16 5-ht3 receptor antagonists

Publications (1)

Publication Number Publication Date
UA113991C2 true UA113991C2 (en) 2017-04-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201500605A UA113991C2 (en) 2012-07-17 2013-07-16 1- (1-methyl-1H-pyrazol-4-yl) -N - ((1R, 5S, 7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] -NONAN-7-yl) -1H-INDOL-3-CARBOXAMID AS A 5-HT3 RECEPTOR ANTAGONIST

Country Status (2)

Country Link
MA (1) MA37836B1 (en)
UA (1) UA113991C2 (en)

Also Published As

Publication number Publication date
MA37836B1 (en) 2018-10-31
MA37836A1 (en) 2018-03-30

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UA113991C2 (en) 1- (1-methyl-1H-pyrazol-4-yl) -N - ((1R, 5S, 7S) -9-methyl-3-oxa-9-azabicyclo [3.3.1] -NONAN-7-yl) -1H-INDOL-3-CARBOXAMID AS A 5-HT3 RECEPTOR ANTAGONIST