Східноукраїнський Національний Університет Імені Володимира Даля
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Subject of invention: 6-(2-R-methylseleno)-4-(2-metoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles. Scope of application: organic synthesis. Summary of invention: 6-(2-R-methylseleno)-4-(2-metoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles characterized by 2-methoxyphenyl fragment in position 4 and various alkylseleno groups in position 6. Technical result: 6-(2-R-methylseleno)-4-(2-metoxyphenyl)-2-oxo-1,2,3,4-tetrahydropyridine-3,5-dicarbonitriles that may be used as the potential biologically active substances possessing the targeted pharmacological activity and the initial substances for synthesis of the novel functionally substituted heterocyclic substances. Their structure has been proven by IR- and NMR 1H-spectroscopy, elemental analysis.
Heterocyclic compounds derived from substituted pyridine carboxamide; Preparation process; pharmaceutical composition; pharmaceutical combination; use in the treatment of cell proliferative disorders, parkinson's disease, cancer, among others.
DERIVATIVES OF N- (HETERO) ARIL-PIRROLIDINA DE PIRAZO-4-IL-PIRROLO [2,3-D] PIRIMIDINES AND PIRROL-3-IL-PIRROLO [2,3-D] PYRIMIDINES AS IHNIBITORS OF THE JANUS KINASE
Compounds derived from 4-azetidinyl-1-heteroaryl-cyclohexanol; pharmaceutical composition; and use in the treatment of diseases such as epoc, atherosclerosis, rheumatoid arthritis, among others.
Compounds derived from difluoro-hexahydro-cyclopentaoxacinyls and difluoro-hexahydro-benzooxacinyls, bace 1 inhibitors; pharmaceutical composition; and its use in the treatment of diseases with elevated levels of beta-amyloid, such as Alzheimer's disease
Compounds derived from 1,2,3,5-tetrahydro-indolizine, 6,7,8,9-tetrahydro-4h-quinolizine substituted, inhibitors of mek kinase activity; its pharmaceutical composition; its use for the treatment of hyperproliferative diseases, such as cancer and inflammation.