UA108346C2 - METHOD OF MODULATION OF ANTAGONISTIC ACTIVITY OF MONOCLONAL ANTIBODY - Google Patents
METHOD OF MODULATION OF ANTAGONISTIC ACTIVITY OF MONOCLONAL ANTIBODYInfo
- Publication number
- UA108346C2 UA108346C2 UAA201108283A UAA201108283A UA108346C2 UA 108346 C2 UA108346 C2 UA 108346C2 UA A201108283 A UAA201108283 A UA A201108283A UA A201108283 A UAA201108283 A UA A201108283A UA 108346 C2 UA108346 C2 UA 108346C2
- Authority
- UA
- Ukraine
- Prior art keywords
- seq
- hinge region
- amino acid
- antagonistic activity
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Abstract
Винахід стосується способу підвищення антагоністичної активності моноклонального химерного або гуманізованого антитіла, що включає константну область IgG1 людини, та націленого проти специфічної молекули-мішені, або його двовалентного функціонального фрагмента, при цьому зазначене антитіло здатне інгібувати одну чи декілька біологічних активностей зазначеної молекули-мішені, де зазначений спосіб включає етап реконфігурації шарнірної області, що полягає у модифікації амінокислотної послідовності зазначеної шарнірної області шляхом видалення, додання або заміни щонайменше однієї амінокислоти, та де зазначена реконфігурована шарнірна область, одержана шляхом модифікації її амінокислотної послідовності, утворює шарнірну область, яка має послідовність вибрану з групи, що складається з послідовностей SEQ ID № 2, SEQ ID № 4, SEQ ID № 6, SEQ ID № 23- SEQ ID № 26, SEQ ID № 36 та SEQ ID № 42 - SEQ ID № 49.The invention relates to a method of increasing the antagonistic activity of a monoclonal chimeric or humanized antibody comprising a constant region of human IgG1 and targeted against a specific target molecule, or its divalent functional fragment, wherein said antibody is capable of inhibiting one or more biological or multifaceted activities. the method includes the step of reconfiguring the hinge region, which is to modify the amino acid sequence of the specified hinge region by removing, adding or replacing at least one amino acid, and wherein said reconfigured hinge region, obtained by modifying its amino acid sequence, forms a hinge region having a sequence selected from the group consisting of SEQ ID No. 2, SEQ ID No. 4, SEQ ID No. 4 # 6, SEQ ID # 23- SEQ ID # 26, SEQ ID # 36, and SEQ ID # 42 - SEQ ID # 49.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/IB2008/055664 WO2010064090A1 (en) | 2008-12-02 | 2008-12-02 | Process for the modulation of the antagonistic activity of a monoclonal antibody |
PCT/EP2009/066205 WO2010063746A1 (en) | 2008-12-02 | 2009-12-02 | Process for the modulation of the antagonistic activity of a monoclonal antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
UA108346C2 true UA108346C2 (en) | 2015-04-27 |
Family
ID=40875011
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201108283A UA108346C2 (en) | 2008-12-02 | 2009-02-12 | METHOD OF MODULATION OF ANTAGONISTIC ACTIVITY OF MONOCLONAL ANTIBODY |
Country Status (2)
Country | Link |
---|---|
UA (1) | UA108346C2 (en) |
WO (1) | WO2010064090A1 (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006106905A1 (en) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
ES2568436T3 (en) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedure to control the blood pharmacokinetics of antibodies |
SG10201605394SA (en) | 2007-09-26 | 2016-08-30 | Chugai Pharmaceutical Co Ltd | Modified Antibody Constant Region |
EP3689912A1 (en) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
US9228017B2 (en) | 2009-03-19 | 2016-01-05 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
JP5787446B2 (en) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | Antibody constant region variants |
EP2481752B1 (en) * | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
JP5889181B2 (en) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | Antibody constant region variants |
AU2011226103C1 (en) | 2010-03-10 | 2016-04-28 | Genmab A/S | Monoclonal antibodies against c-Met |
MX2014002289A (en) | 2011-08-26 | 2015-03-20 | Merrimack Pharmaceuticals Inc | Tandem fc bispecific antibodies. |
US9931400B2 (en) | 2012-09-12 | 2018-04-03 | Samsung Electronics Co., Ltd. | Method of combination therapy for prevention or treatment of c-Met or angiogenesis factor induced diseases |
KR20150143458A (en) | 2013-03-06 | 2015-12-23 | 메리맥 파마슈티컬즈, 인크. | ANTI-C-MET Tandem Fc Bispecific Antibodies |
KR102441231B1 (en) | 2013-09-27 | 2022-09-06 | 추가이 세이야쿠 가부시키가이샤 | Method for producing polypeptide heteromultimer |
US9717715B2 (en) | 2013-11-15 | 2017-08-01 | Samsung Electronics Co., Ltd. | Method of combination therapy using an anti-C-Met antibody |
EP3279216A4 (en) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
TW201825515A (en) | 2017-01-04 | 2018-07-16 | 美商伊繆諾金公司 | Met antibodies and immunoconjugates and uses thereof |
WO2020014306A1 (en) | 2018-07-10 | 2020-01-16 | Immunogen, Inc. | Met antibodies and immunoconjugates and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004309275B2 (en) * | 2003-12-25 | 2010-12-23 | Kyowa Kirin Co., Ltd. | Mutants of anti-CD40 antibody |
JP5142998B2 (en) * | 2005-07-18 | 2013-02-13 | アムジエン・インコーポレーテツド | Human anti-B7RP1 neutralizing antibody |
US8652469B2 (en) * | 2005-07-28 | 2014-02-18 | Novartis Ag | M-CSF-specific monoclonal antibody and uses thereof |
EP2004693B1 (en) * | 2006-03-30 | 2012-06-06 | Novartis AG | Compositions and methods of use for antibodies of c-met |
-
2008
- 2008-12-02 WO PCT/IB2008/055664 patent/WO2010064090A1/en active Application Filing
-
2009
- 2009-02-12 UA UAA201108283A patent/UA108346C2/en unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010064090A1 (en) | 2010-06-10 |
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