UA106491C2 - Застосування суміші галактоолігосахаридів, що мають ступінь полімеризації 3 або більше - Google Patents
Застосування суміші галактоолігосахаридів, що мають ступінь полімеризації 3 або більше Download PDFInfo
- Publication number
- UA106491C2 UA106491C2 UAA201113760A UAA201113760A UA106491C2 UA 106491 C2 UA106491 C2 UA 106491C2 UA A201113760 A UAA201113760 A UA A201113760A UA A201113760 A UAA201113760 A UA A201113760A UA 106491 C2 UA106491 C2 UA 106491C2
- Authority
- UA
- Ukraine
- Prior art keywords
- cells
- tme
- mir
- secretion
- hos
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title description 13
- 238000006116 polymerization reaction Methods 0.000 title 1
- 235000021255 galacto-oligosaccharides Nutrition 0.000 abstract description 28
- 150000003271 galactooligosaccharides Chemical class 0.000 abstract description 26
- 208000027866 inflammatory disease Diseases 0.000 abstract description 3
- 230000000968 intestinal effect Effects 0.000 abstract description 2
- 230000002265 prevention Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 54
- 230000028327 secretion Effects 0.000 description 26
- 230000000694 effects Effects 0.000 description 24
- 102000004127 Cytokines Human genes 0.000 description 16
- 108090000695 Cytokines Proteins 0.000 description 16
- 238000000034 method Methods 0.000 description 15
- 241000699670 Mus sp. Species 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 12
- 229920003045 dextran sodium sulfate Polymers 0.000 description 11
- 230000000638 stimulation Effects 0.000 description 11
- 239000002609 medium Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 108020004999 messenger RNA Proteins 0.000 description 8
- 108091028838 miR-2 stem-loop Proteins 0.000 description 7
- 206010009887 colitis Diseases 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 6
- 108010040721 Flagellin Proteins 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 5
- 210000001072 colon Anatomy 0.000 description 5
- 238000011534 incubation Methods 0.000 description 5
- 230000002757 inflammatory effect Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 241000283973 Oryctolagus cuniculus Species 0.000 description 4
- 230000003247 decreasing effect Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 229920001542 oligosaccharide Polymers 0.000 description 4
- 150000002482 oligosaccharides Chemical class 0.000 description 4
- 239000013641 positive control Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 229930182555 Penicillin Natural products 0.000 description 3
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 3
- GLNADSQYFUSGOU-GPTZEZBUSA-J Trypan blue Chemical compound [Na+].[Na+].[Na+].[Na+].C1=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(/N=N/C3=CC=C(C=C3C)C=3C=C(C(=CC=3)\N=N\C=3C(=CC4=CC(=CC(N)=C4C=3O)S([O-])(=O)=O)S([O-])(=O)=O)C)=C(O)C2=C1N GLNADSQYFUSGOU-GPTZEZBUSA-J 0.000 description 3
- 230000003833 cell viability Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- 230000007717 exclusion Effects 0.000 description 3
- 238000002270 exclusion chromatography Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 244000005706 microflora Species 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 229940049954 penicillin Drugs 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 238000003753 real-time PCR Methods 0.000 description 3
- 229960005322 streptomycin Drugs 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 238000000692 Student's t-test Methods 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 238000004113 cell culture Methods 0.000 description 2
- 230000016396 cytokine production Effects 0.000 description 2
- 230000003013 cytotoxicity Effects 0.000 description 2
- 231100000135 cytotoxicity Toxicity 0.000 description 2
- 239000003651 drinking water Substances 0.000 description 2
- 235000020188 drinking water Nutrition 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 210000004347 intestinal mucosa Anatomy 0.000 description 2
- 239000007937 lozenge Substances 0.000 description 2
- 108091084679 miR-3 stem-loop Proteins 0.000 description 2
- 108091033354 miR-3-1 stem-loop Proteins 0.000 description 2
- 108091058771 miR-3-2 stem-loop Proteins 0.000 description 2
- 229940126619 mouse monoclonal antibody Drugs 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 102000005962 receptors Human genes 0.000 description 2
- 239000002356 single layer Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 239000006188 syrup Substances 0.000 description 2
- 235000020357 syrup Nutrition 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- GEYOCULIXLDCMW-UHFFFAOYSA-N 1,2-phenylenediamine Chemical compound NC1=CC=CC=C1N GEYOCULIXLDCMW-UHFFFAOYSA-N 0.000 description 1
- 101100222092 Caenorhabditis elegans csp-3 gene Proteins 0.000 description 1
- 241000132536 Cirsium Species 0.000 description 1
- 108010078777 Colistin Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229930182566 Gentamicin Natural products 0.000 description 1
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 241001214257 Mene Species 0.000 description 1
- 102100028647 Mu-type opioid receptor Human genes 0.000 description 1
- 101710178223 Mu-type opioid receptor Proteins 0.000 description 1
- 241001529936 Murinae Species 0.000 description 1
- 101100123117 Nicotiana plumbaginifolia MSR-1 gene Proteins 0.000 description 1
- 241000120614 Olinia Species 0.000 description 1
- 229930040373 Paraformaldehyde Natural products 0.000 description 1
- 102000003992 Peroxidases Human genes 0.000 description 1
- 241000181331 Saron Species 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- 108010059993 Vancomycin Proteins 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- RIIWUGSYXOBDMC-UHFFFAOYSA-N benzene-1,2-diamine;hydron;dichloride Chemical compound Cl.Cl.NC1=CC=CC=C1N RIIWUGSYXOBDMC-UHFFFAOYSA-N 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 108091092328 cellular RNA Proteins 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229960003346 colistin Drugs 0.000 description 1
- 230000008951 colonic inflammation Effects 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000005227 gel permeation chromatography Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 235000012171 hot beverage Nutrition 0.000 description 1
- 235000020256 human milk Nutrition 0.000 description 1
- 210000004251 human milk Anatomy 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 210000002490 intestinal epithelial cell Anatomy 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 229960000318 kanamycin Drugs 0.000 description 1
- 229930027917 kanamycin Natural products 0.000 description 1
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 1
- 229930182823 kanamycin A Natural products 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 229960000282 metronidazole Drugs 0.000 description 1
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000010172 mouse model Methods 0.000 description 1
- JORAUNFTUVJTNG-BSTBCYLQSA-N n-[(2s)-4-amino-1-[[(2s,3r)-1-[[(2s)-4-amino-1-oxo-1-[[(3s,6s,9s,12s,15r,18s,21s)-6,9,18-tris(2-aminoethyl)-3-[(1r)-1-hydroxyethyl]-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-h Chemical compound CC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O.CCC(C)CCCCC(=O)N[C@@H](CCN)C(=O)N[C@H]([C@@H](C)O)CN[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O JORAUNFTUVJTNG-BSTBCYLQSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229920002866 paraformaldehyde Polymers 0.000 description 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
- 230000008823 permeabilization Effects 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- XDJYMJULXQKGMM-UHFFFAOYSA-N polymyxin E1 Natural products CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O XDJYMJULXQKGMM-UHFFFAOYSA-N 0.000 description 1
- KNIWPHSUTGNZST-UHFFFAOYSA-N polymyxin E2 Natural products CC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(C(C)O)NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CCN)NC1=O KNIWPHSUTGNZST-UHFFFAOYSA-N 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000001542 size-exclusion chromatography Methods 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000013518 transcription Methods 0.000 description 1
- 230000035897 transcription Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 150000004043 trisaccharides Chemical class 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229960003165 vancomycin Drugs 0.000 description 1
- MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
- MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0906983.2A GB0906983D0 (en) | 2009-04-23 | 2009-04-23 | Novel use |
| PCT/GB2010/050659 WO2010122344A1 (en) | 2009-04-23 | 2010-04-23 | Novel use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA106491C2 true UA106491C2 (uk) | 2014-09-10 |
Family
ID=40774842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UAA201113760A UA106491C2 (uk) | 2009-04-23 | 2010-04-23 | Застосування суміші галактоолігосахаридів, що мають ступінь полімеризації 3 або більше |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20120058972A1 (enExample) |
| EP (1) | EP2421541B1 (enExample) |
| JP (1) | JP2012524770A (enExample) |
| KR (1) | KR20110138416A (enExample) |
| CN (1) | CN102427818A (enExample) |
| AU (1) | AU2010240642B2 (enExample) |
| BR (1) | BRPI1015091A2 (enExample) |
| CA (1) | CA2759442C (enExample) |
| CY (1) | CY1120597T1 (enExample) |
| DK (1) | DK2421541T3 (enExample) |
| ES (1) | ES2688786T3 (enExample) |
| GB (3) | GB0906983D0 (enExample) |
| HU (1) | HUE040451T2 (enExample) |
| IL (1) | IL215855A0 (enExample) |
| MX (1) | MX341308B (enExample) |
| MY (1) | MY151104A (enExample) |
| NZ (1) | NZ595969A (enExample) |
| PL (1) | PL2421541T3 (enExample) |
| PT (1) | PT2421541T (enExample) |
| RU (1) | RU2530567C2 (enExample) |
| SG (1) | SG175313A1 (enExample) |
| TR (1) | TR201810868T4 (enExample) |
| UA (1) | UA106491C2 (enExample) |
| WO (1) | WO2010122344A1 (enExample) |
| ZA (1) | ZA201107821B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2492559B (en) * | 2011-07-05 | 2018-07-25 | Clasado Inc | Composition and method for preventing or reducing the risk of developing a syndrome |
| BR112014001472A2 (pt) | 2011-07-22 | 2017-02-21 | Abbott Lab | galactooligossacarídeos para prevenir lesões e / ou promover a cicatrização do trato gastrointestinal |
| CN103716787B (zh) | 2012-09-29 | 2020-06-23 | 北京三星通信技术研究有限公司 | 一种支持对家用基站进行验证的方法 |
| CA2983236A1 (en) | 2015-04-23 | 2016-10-27 | Kaleido Biosciences, Inc. | Glycan therapeutics and methods of treatment |
| CN107158011A (zh) * | 2017-05-25 | 2017-09-15 | 浙江大学 | 低聚半乳糖在制备治疗肠道疾病的药物中的用途 |
| BR112021022447A2 (pt) * | 2019-05-15 | 2021-12-28 | Nutricia Nv | Métodos para aumentar a função da barreira intestinal e/ou para a prevenção e/ou o tratamento de ruptura da barreira intestinal, método para o tratamento, a prevenção e/ou o alívio de uma condição associado à exposição a toxinas, fórmula infantil, fórmula de seguimento ou fórmula para criança de primeira infância, trissacarídeos, composições nutricionais, uso do trissacarídeo e usos de uma composição nutricional |
| US20240277739A1 (en) * | 2021-07-01 | 2024-08-22 | N.V. Nutricia | Nutritonal compositions for gut barrier function |
| KR102453998B1 (ko) * | 2022-01-07 | 2022-10-14 | (주)네오크레마 | 갈락토올리고당을 포함하는 염증성 장질환의 예방, 개선 또는 치료용 조성물 |
| GB2619977A (en) * | 2022-06-24 | 2023-12-27 | Clasado Res Services Limited | Compositions and uses thereof |
| GB2623336A (en) * | 2022-10-12 | 2024-04-17 | Clasado Res Services Limited | Compositions and uses thereof |
| GB2623335A (en) * | 2022-10-12 | 2024-04-17 | Clasado Res Services Limited | Compositions and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0229015D0 (en) * | 2002-12-12 | 2003-01-15 | Novartis Nutrition Ag | New Compound |
| GB0315266D0 (en) * | 2003-06-30 | 2003-08-06 | Clasado Inc | Novel galactooligosaccharide composition and the preparation thereof |
| EP1644482B2 (en) * | 2003-06-30 | 2014-10-01 | Clasado Inc. | Novel galactooligosaccharide composition and the preparation thereof |
| EP1597978A1 (en) | 2004-05-17 | 2005-11-23 | Nutricia N.V. | Synergism of GOS and polyfructose |
| EP1887017A1 (en) * | 2006-08-09 | 2008-02-13 | Friesland Brands B.V. | Prebiotic carbohydrate |
| GB0809921D0 (en) * | 2008-05-30 | 2008-07-09 | Clasado Inc | Product and process therefor |
-
2009
- 2009-04-23 GB GBGB0906983.2A patent/GB0906983D0/en not_active Ceased
- 2009-11-27 GB GBGB0920784.6A patent/GB0920784D0/en not_active Ceased
-
2010
- 2010-04-23 US US13/265,532 patent/US20120058972A1/en not_active Abandoned
- 2010-04-23 RU RU2011147390/15A patent/RU2530567C2/ru not_active IP Right Cessation
- 2010-04-23 BR BRPI1015091A patent/BRPI1015091A2/pt not_active Application Discontinuation
- 2010-04-23 GB GB1120030.0A patent/GB2482817B/en active Active
- 2010-04-23 PT PT10714956T patent/PT2421541T/pt unknown
- 2010-04-23 MY MYPI2011004912 patent/MY151104A/en unknown
- 2010-04-23 CA CA2759442A patent/CA2759442C/en active Active
- 2010-04-23 DK DK10714956.9T patent/DK2421541T3/en active
- 2010-04-23 UA UAA201113760A patent/UA106491C2/uk unknown
- 2010-04-23 JP JP2012506581A patent/JP2012524770A/ja active Pending
- 2010-04-23 TR TR2018/10868T patent/TR201810868T4/tr unknown
- 2010-04-23 CN CN2010800180409A patent/CN102427818A/zh active Pending
- 2010-04-23 EP EP10714956.9A patent/EP2421541B1/en not_active Revoked
- 2010-04-23 MX MX2011011159A patent/MX341308B/es active IP Right Grant
- 2010-04-23 NZ NZ595969A patent/NZ595969A/xx not_active IP Right Cessation
- 2010-04-23 PL PL10714956T patent/PL2421541T3/pl unknown
- 2010-04-23 AU AU2010240642A patent/AU2010240642B2/en active Active
- 2010-04-23 HU HUE10714956A patent/HUE040451T2/hu unknown
- 2010-04-23 WO PCT/GB2010/050659 patent/WO2010122344A1/en not_active Ceased
- 2010-04-23 KR KR1020117027762A patent/KR20110138416A/ko not_active Ceased
- 2010-04-23 ES ES10714956.9T patent/ES2688786T3/es active Active
- 2010-04-23 SG SG2011077443A patent/SG175313A1/en unknown
-
2011
- 2011-10-23 IL IL215855A patent/IL215855A0/en unknown
- 2011-10-25 ZA ZA2011/07821A patent/ZA201107821B/en unknown
-
2018
- 2018-08-13 CY CY181100857T patent/CY1120597T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2421541A1 (en) | 2012-02-29 |
| HUE040451T2 (hu) | 2019-03-28 |
| GB2482817B (en) | 2014-02-26 |
| KR20110138416A (ko) | 2011-12-27 |
| RU2530567C2 (ru) | 2014-10-10 |
| NZ595969A (en) | 2013-03-28 |
| WO2010122344A1 (en) | 2010-10-28 |
| PT2421541T (pt) | 2018-10-15 |
| CY1120597T1 (el) | 2019-12-11 |
| CA2759442C (en) | 2016-01-19 |
| CA2759442A1 (en) | 2010-10-28 |
| SG175313A1 (en) | 2011-11-28 |
| GB201120030D0 (en) | 2012-01-04 |
| TR201810868T4 (tr) | 2018-08-27 |
| IL215855A0 (en) | 2012-01-31 |
| MY151104A (en) | 2014-04-15 |
| EP2421541B1 (en) | 2018-07-11 |
| ZA201107821B (en) | 2012-07-25 |
| AU2010240642A1 (en) | 2011-11-10 |
| PL2421541T3 (pl) | 2018-11-30 |
| CN102427818A (zh) | 2012-04-25 |
| GB0920784D0 (en) | 2010-01-13 |
| AU2010240642B2 (en) | 2013-03-14 |
| ES2688786T3 (es) | 2018-11-06 |
| GB2482817A (en) | 2012-02-15 |
| JP2012524770A (ja) | 2012-10-18 |
| MX341308B (es) | 2016-08-12 |
| DK2421541T3 (en) | 2018-09-24 |
| BRPI1015091A2 (pt) | 2016-04-26 |
| GB0906983D0 (en) | 2009-06-03 |
| US20120058972A1 (en) | 2012-03-08 |
| RU2011147390A (ru) | 2013-05-27 |
| MX2011011159A (es) | 2011-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| UA106491C2 (uk) | Застосування суміші галактоолігосахаридів, що мають ступінь полімеризації 3 або більше | |
| Tao et al. | Mogroside IIIE attenuates LPS‐induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF‐κB axis via AMPK activation | |
| KR101826071B1 (ko) | 포유동물 체내에서 유래된 세포밖 소포체를 포함하는 조성물 및 이의 용도 | |
| Locatelli et al. | Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice | |
| Chun et al. | Peucedanum japonicum extract attenuates allergic airway inflammation by inhibiting Th2 cell activation and production of pro-inflammatory mediators | |
| Jeong et al. | Anti-inflammatory effects of vina-ginsenoside R2 and majonoside R2 isolated from Panax vietnamensis and their metabolites in lipopolysaccharide-stimulated macrophages | |
| Zeng et al. | An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway | |
| EP2288356A1 (en) | Use of prebiotic galacto-oligosaccharides in the treatment of intestinal inflammation | |
| Chen et al. | Polysaccharides from Dendrobium officinale inhibit bleomycin-induced pulmonary fibrosis via the TGFβ1-Smad2/3 axis | |
| Yu et al. | Piperine protects LPS-induced mastitis by inhibiting inflammatory response | |
| Bo et al. | Celastrol induces caspase-dependent apoptosis of hepatocellular carcinoma cells by suppression of mammalian target of rapamycin. | |
| Sultana et al. | Inhibition of inflammatory signaling pathways in 3T3‐L1 adipocytes by apolipoprotein A‐I | |
| Zhang et al. | Dendrobium officinale polysaccharides attenuate uropathogenic Escherichia coli (UPEC)-induced pyroptosis in macrophage cells | |
| Martens et al. | Lacticaseibacillus casei AMBR2 restores airway epithelial integrity in chronic rhinosinusitis with nasal polyps | |
| Liu et al. | 2′-Fucosyllactose promotes colonization of Akkermansia muciniphila and prevents colitis in vitro and in mice | |
| Zhang et al. | Purification and identification of lipid-lowering protein from barley extract after Lactiplantibacillus plantarum dy-1 fermentation | |
| Chen et al. | Oral Plant‐Derived Nanomedicines Mitigate Acetaminophen‐Induced Liver Injury by Modulating the Gut‐Liver Axis and Intestinal Microbiota Metabolism | |
| Ismail et al. | Ellagic acid protects against activation of microglia by inhibiting MAPKs and NF-κB signalling | |
| Xu et al. | Molecular mechanism of icariin on rat asthmatic model | |
| Li et al. | Anti-inflammatory effects of PMX205 in mouse macrophage periodontitis model | |
| Wang et al. | Bacillus velezensis MZ09 alleviates DSS-induced colitis in piglets by remodeling the intestinal microbiota activating the SCFAs–GPR43–STAT3 pathway and suppressing NLRP3 inflammasome-mediated pyroptosis | |
| Han et al. | Oridonin alleviates inflammation and endoplasmic reticulum stress in pediatric pneumonia via regulating the SIRT1-mediated Wnt/β-catenin signaling pathway | |
| Chen et al. | Tripterygium polyglycosid attenuates the established airway inflammation in asthmatic mice | |
| Cai et al. | Reduction of inflammation response and transition of M1 toward M2 phenotypes of macrophages in response to SiO2 challenge by inhibition of TLR4. | |
| Zhu et al. | Celastrus orbiculatus Extract Inhibits Immune Inflammatory Thrombotic State of B-Lymphoma |