UA103490C2 - Composition of flavanolignan and amino acid with improved water solubility - Google Patents
Composition of flavanolignan and amino acid with improved water solubilityInfo
- Publication number
- UA103490C2 UA103490C2 UAA201100594A UAA201100594A UA103490C2 UA 103490 C2 UA103490 C2 UA 103490C2 UA A201100594 A UAA201100594 A UA A201100594A UA A201100594 A UAA201100594 A UA A201100594A UA 103490 C2 UA103490 C2 UA 103490C2
- Authority
- UA
- Ukraine
- Prior art keywords
- flavanolignan
- composition
- amino acid
- water solubility
- improved water
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
The invention relates to a composition containing flavanolignans, e.g., isolated from Silybum marianum, and basic amino acids and, optionally, other auxiliary substances, in the form of mixture, and to the method of preparation of these compositions by mixing the components and their homogenization. The invention is applicable particularly in the pharmaceutical industry, cosmetics, food industry, breweries, distilleries, and in the industry of beverage production. Formula (I)(I),
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20080407A CZ300846B6 (en) | 2008-06-26 | 2008-06-26 | Water-soluble composition based on flavanonol lignanes and process for preparing thereof |
PCT/CZ2009/000086 WO2009155887A1 (en) | 2008-06-26 | 2009-06-22 | Composition of flavanolignan and amino acid with improved water solubility |
Publications (1)
Publication Number | Publication Date |
---|---|
UA103490C2 true UA103490C2 (en) | 2013-10-25 |
Family
ID=40986372
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA201100594A UA103490C2 (en) | 2008-06-26 | 2009-06-22 | Composition of flavanolignan and amino acid with improved water solubility |
Country Status (14)
Country | Link |
---|---|
US (1) | US8426459B2 (en) |
EP (1) | EP2307405B1 (en) |
JP (1) | JP2011525498A (en) |
CN (1) | CN102066364A (en) |
AU (1) | AU2009264469A1 (en) |
BR (1) | BRPI0914180A2 (en) |
CA (1) | CA2727197A1 (en) |
CZ (1) | CZ300846B6 (en) |
EA (1) | EA016903B1 (en) |
MX (1) | MX2010014466A (en) |
PL (1) | PL2307405T3 (en) |
UA (1) | UA103490C2 (en) |
WO (1) | WO2009155887A1 (en) |
ZA (1) | ZA201100265B (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ2008841A3 (en) * | 2008-12-23 | 2010-07-28 | Agra Group, A.S. | Beer and beer-based beverages and method of adjusting content of polyphenols and silicon therein |
UA97282C2 (en) * | 2010-02-09 | 2012-01-25 | Евгений Леонидович Юхниця | Composition and process for the production of “radoi” beer |
WO2016149685A1 (en) | 2015-03-19 | 2016-09-22 | Cydex Pharmaceuticals, Inc. | Compositions containing silymarin and sulfoalkyl ether cyclodextrin and methods of using the same |
CZ308418B6 (en) * | 2015-06-23 | 2020-08-12 | Mendelova Univerzita V Brně, Zahradnická Fakulta,Ústav Posklizňové Technologie Zahradnických Produktů | Beer or beer-based beverage containing lignans and method of producing it |
TWI761672B (en) | 2018-04-23 | 2022-04-21 | 日商阿爾卑斯藥品工業股份有限公司 | Compositions of o-glycosyl flavonoids |
JP7214247B2 (en) * | 2018-06-09 | 2023-01-30 | 江▲蘇▼新元素医▲薬▼科技有限公司 | COMPOUNDS FOR THE TREATMENT OR PREVENTION OF LIVER DISEASE |
US10918654B1 (en) | 2019-09-23 | 2021-02-16 | Alps Pharmaceutical Ind. Co., Ltd. | Rutin compositions |
US11110109B2 (en) | 2019-10-22 | 2021-09-07 | Alps Pharmaceutical Ind. Co., Ltd. | Water soluble O-glycosyl flavonoid compositions and methods for preparing same |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT332535B (en) * | 1973-01-19 | 1976-10-11 | Madaus & Co Dr | PROCESS FOR THE PRODUCTION OF NEW WATER-SOLUBLE SALT OF THE ACTIVE SUBSTANCES OF THE SILYMARING GROUP |
GB1554662A (en) * | 1976-05-05 | 1979-10-24 | Inverni Della Beffa Spa | Polyhydroxyphenylchromanones |
IT1215291B (en) * | 1985-07-17 | 1990-01-31 | Inverni Della Beffa Spa | FLAVANOLIGNANI COMPLEXES WITH PHOSPHOLIPIDS, THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS. |
IT1222012B (en) * | 1987-07-10 | 1990-08-31 | Indena Spa | PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING COMPLEX FLAVONOLIGNANS WITH PHOSPHOLIPIDS |
GB8716918D0 (en) * | 1987-07-17 | 1987-08-26 | Inverni Della Beffa Spa | Soluble derivatives of silybin |
IT1241673B (en) * | 1989-10-09 | 1994-01-27 | Istituto Biochimico Italiano | INCLUSION COMPLEXES OF SILIBININ WITH CYCLODESTRINE, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
US5196448A (en) * | 1991-01-22 | 1993-03-23 | Stiefel Laboratories, Inc. | Antiinflammatory compositions and method of use |
GB2261434A (en) * | 1991-11-15 | 1993-05-19 | Inverni Della Beffa Spa | New radical scavenging and antipoperoxidant flavanolignans their preparation and formulations for therapeutic use |
DE4401902C2 (en) * | 1994-01-24 | 2000-02-03 | Madaus Ag | Use of flavolignans as an adjuvant in tumor therapy |
DE19501266A1 (en) | 1995-01-18 | 1996-07-25 | Madaus Ag | Process for the preparation of flavano-lignan preparations with improved release and resorbability, preparations available thereafter and their use for the production of medicaments |
IT1274549B (en) * | 1995-05-23 | 1997-07-17 | Indena Spa | USE OF FLAVANOLIGNANI FOR THE PREPARATION OF MEDICATIONS FOR ANTI-PROLIFERATIVE ACTIVITY IN CANCER OF THE UTERUS, OVARIAN AND BREAST |
CZ287657B6 (en) | 1996-06-12 | 2001-01-17 | Mikrobiologický Ústav Av Čr | Silybinin glycosides and process of their preparation |
WO1998000570A1 (en) * | 1996-07-02 | 1998-01-08 | The Timken Company | Induction hardened microalloy steel having enhanced fatigue strength properties |
JP3656972B2 (en) * | 1997-02-14 | 2005-06-08 | 丸善製薬株式会社 | Alcohol smell reducing agent |
CZ292832B6 (en) | 2001-08-30 | 2003-12-17 | Ivax Pharmaceuticals S.R.O. | Process for preparing silymarin exhibiting increased solubility |
CN1397277A (en) * | 2002-08-16 | 2003-02-19 | 广州瑞济生物技术有限公司 | Process for preapring silymanium injection |
US6913769B2 (en) * | 2003-02-18 | 2005-07-05 | Brian Douglas Oslick | Compositions for prevention and treatment of symptoms associated with ethyl alcohol consumption |
CN100402023C (en) * | 2003-06-21 | 2008-07-16 | 山东绿叶天然药物研究开发有限公司 | Legalon soft capsule and its preparing method |
CN1490001A (en) * | 2003-09-08 | 2004-04-21 | 南昌弘益科技有限公司 | Hepadestal drops and preparation thereof |
CN1666739A (en) * | 2004-03-08 | 2005-09-14 | 山东绿叶天然药物研究开发有限公司 | Application of Silibinin or its salts in preparation of medicine for treating coronary heart disease or strengthening the effect of coronary heart disease treatment |
CN1247195C (en) * | 2004-07-19 | 2006-03-29 | 北京科信必成医药科技发展有限公司 | Silibinin oral disintegration tablet and its preparing method |
US20060067959A1 (en) * | 2004-09-28 | 2006-03-30 | Marcel Nimni | Compositions and methods for treatment of solar damage |
CN100546577C (en) * | 2004-11-22 | 2009-10-07 | 山东绿叶天然药物研究开发有限公司 | The new medical use of silibinin or its salt |
JP3914244B2 (en) * | 2005-10-03 | 2007-05-16 | 株式会社ファンケル | Abnormal protein removal composition |
JP4954531B2 (en) * | 2005-10-31 | 2012-06-20 | 一丸ファルコス株式会社 | Peroxisome proliferator-responsive receptor activator |
CA2645073A1 (en) * | 2006-03-08 | 2007-09-13 | Nuviance, Inc. | Transdermal drug delivery compositions and topical compositions for application on the skin |
-
2008
- 2008-06-26 CZ CZ20080407A patent/CZ300846B6/en not_active IP Right Cessation
-
2009
- 2009-06-22 AU AU2009264469A patent/AU2009264469A1/en not_active Abandoned
- 2009-06-22 BR BRPI0914180A patent/BRPI0914180A2/en not_active IP Right Cessation
- 2009-06-22 CN CN2009801240442A patent/CN102066364A/en active Pending
- 2009-06-22 UA UAA201100594A patent/UA103490C2/en unknown
- 2009-06-22 US US13/000,607 patent/US8426459B2/en not_active Expired - Fee Related
- 2009-06-22 MX MX2010014466A patent/MX2010014466A/en not_active Application Discontinuation
- 2009-06-22 JP JP2011515082A patent/JP2011525498A/en active Pending
- 2009-06-22 EA EA201100091A patent/EA016903B1/en not_active IP Right Cessation
- 2009-06-22 WO PCT/CZ2009/000086 patent/WO2009155887A1/en active Application Filing
- 2009-06-22 PL PL09768812T patent/PL2307405T3/en unknown
- 2009-06-22 CA CA2727197A patent/CA2727197A1/en not_active Abandoned
- 2009-06-22 EP EP09768812.1A patent/EP2307405B1/en not_active Not-in-force
-
2011
- 2011-01-10 ZA ZA2011/00265A patent/ZA201100265B/en unknown
Also Published As
Publication number | Publication date |
---|---|
EA016903B1 (en) | 2012-08-30 |
EA201100091A1 (en) | 2011-06-30 |
EP2307405B1 (en) | 2013-10-02 |
JP2011525498A (en) | 2011-09-22 |
ZA201100265B (en) | 2011-10-26 |
US20110207805A1 (en) | 2011-08-25 |
MX2010014466A (en) | 2011-04-28 |
WO2009155887A1 (en) | 2009-12-30 |
US8426459B2 (en) | 2013-04-23 |
CZ2008407A3 (en) | 2009-08-26 |
PL2307405T3 (en) | 2014-04-30 |
EP2307405A1 (en) | 2011-04-13 |
CN102066364A (en) | 2011-05-18 |
CA2727197A1 (en) | 2009-12-30 |
BRPI0914180A2 (en) | 2015-10-20 |
CZ300846B6 (en) | 2009-08-26 |
AU2009264469A1 (en) | 2009-12-30 |
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