UA101142C2 - Method for antibody designing - Google Patents

Method for antibody designing

Info

Publication number
UA101142C2
UA101142C2 UAA200811356A UAA200811356A UA101142C2 UA 101142 C2 UA101142 C2 UA 101142C2 UA A200811356 A UAA200811356 A UA A200811356A UA A200811356 A UAA200811356 A UA A200811356A UA 101142 C2 UA101142 C2 UA 101142C2
Authority
UA
Ukraine
Prior art keywords
amino acids
covariative
annealing
candidate
acid sequences
Prior art date
Application number
UAA200811356A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Стивен Димарест
Скотт Глейзер
Брайан Роберт Миллер
Ксиуфенг Ву
Уильям Б. Снайдер
Норман Ванг
Лайза Дж. Кроне
Алексей Александрович Луговской
Original Assignee
Байоджэн Айдэк Ма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджэн Айдэк Ма Инк. filed Critical Байоджэн Айдэк Ма Инк.
Priority claimed from PCT/US2007/006883 external-priority patent/WO2007109254A2/en
Publication of UA101142C2 publication Critical patent/UA101142C2/en

Links

Classifications

    • Y02A90/26—

Abstract

The invention relates to method for designing of antibody or its antigen-binging fragment by providing corrected comparison set of amino acid sequences, containing sequence corresponding to immunoglobulin type of protein packing, annealing of amino acid sequences of comparison set with corrected set production, determination of covariations between two or more positions of residues in annealing set with production of covariation data set, identification of non-covariative amino acids in the mentioned gene-candidate, where the corresponding amino acids in the sequences of the set represent covariative amino acids, and substitutions of non-covariative amino acids of the candidate sequence with corresponding covariatite amino acids in comparison set, improving biophysiological property of candidate sequence.
UAA200811356A 2006-03-17 2007-03-19 Method for antibody designing UA101142C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78362206P 2006-03-17 2006-03-17
PCT/US2007/006883 WO2007109254A2 (en) 2006-03-17 2007-03-19 Stabilized polypeptide compositions

Publications (1)

Publication Number Publication Date
UA101142C2 true UA101142C2 (en) 2013-03-11

Family

ID=40743757

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200811356A UA101142C2 (en) 2006-03-17 2007-03-19 Method for antibody designing

Country Status (3)

Country Link
CN (1) CN101448853A (en)
UA (1) UA101142C2 (en)
ZA (1) ZA200807964B (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201005063D0 (en) * 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
EA201400709A1 (en) * 2011-12-19 2016-08-31 Синиммун Гмбх MOLECULE OF BISPECIFIC ANTIBODY
EP2967015B9 (en) * 2013-03-11 2023-08-09 Regeneron Pharmaceuticals, Inc. Transgenic mice expressing chimeric major histocompatibility complex (mhc) class ii molecules
CN105560635A (en) * 2015-09-17 2016-05-11 张名静 Traditional Chinese medicine formula for treating acanthosis nigricans
KR102429287B1 (en) * 2015-12-10 2022-08-05 가부시끼가이샤 메니콘 Peptide composition
EP3645708A4 (en) * 2017-06-30 2021-06-23 Memorial Sloan-Kettering Cancer Center Compositions and methods for adoptive cell therapy for cancer
CN109879964B (en) * 2017-12-06 2022-08-05 北京科立思维生物科技有限公司 anti-EGFR single-chain antibody, anti-PD 1 single-chain antibody and fusion protein
TW202029980A (en) * 2018-10-26 2020-08-16 美商免疫遺傳股份有限公司 Epcam antibodies, activatable antibodies, and immunoconjugates, and uses thereof
CN114271237B (en) * 2022-03-07 2022-05-27 南京农业大学 Method for breeding long-short velvet self-sexing pigeons

Also Published As

Publication number Publication date
ZA200807964B (en) 2009-10-28
CN101448853A (en) 2009-06-03

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