TWM662011U - Electromagnetic stimulation equipment and booster device - Google Patents

Abstract

The invention is an electromagnetic stimulation device and a voltage boosting device thereof, wherein the voltage boosting device utilizes a plurality of first and second current direction limiting elements and first and second energy storage elements to store energy for generating direct current high voltage for electromagnetic stimulation. Furthermore, the first current direction limiting element and the first energy storage element are electrically connected in series with the external power source, the first current direction limiting element is connected in parallel with the second current direction limiting element having the opposite current limiting direction, and the second current direction limiting element is connected in series with the second energy storage element; the first and second current direction limiting elements are conductive or non-conductive according to the polarity of the input voltage, so as to switch the current direction so that the external power source charges the first and second energy storage elements respectively in different cycles, and the charging process of the second energy storage element is provided by the external power source and the first energy storage element, and has a cross-voltage that is twice that of the first energy storage element, and the second energy storage elements are connected in series with each other for output application.

Description

Electromagnetic stimulation equipment and booster device

This invention is related to the field of bioelectromagnetic stimulation equipment, especially a booster device that converts external input AC power into DC high voltage sufficient to supply electromagnetic stimulation intensity and its electromagnetic stimulation equipment, thereby replacing the traditional linear transformer approach while still maintaining the electromagnetic stimulation performance and having the effect of lightweight equipment, etc.

In order to study neuroscience and improve neuropsychiatric diseases, some electromagnetic stimulation devices have been proposed. They use alternating magnetic fields to simulate electrical signals to affect various parts of the body. For example, transcranial magnetic stimulation (TMS) devices use non-invasive neuromodulation technology to generate changing magnetic fields through magnetic field coils placed on the scalp to affect brain activity. Generally, the critical stimulation parameters corresponding to various parts of the body will vary depending on the target site, improvement plan, stimulation depth, and neural conditions. However, the electromagnetic stimulation devices commonly installed in medical institutions often still require extremely high voltages to generate high currents in order to effectively generate magnetic fields that are stimulating to the brain or nerves to activate neurons and enable nerves to reach action potentials. Taking TMS technology as an example, in the past, depending on the depth of the stimulation target and the neural conditions, in order to achieve the expected stimulation threshold, the voltage usually required at least 300 volts (V) or even thousands of volts. Furthermore, due to the special nature of the human body, in addition to requiring high voltage and high current, the stimulation frequency range also has an optimal operating frequency of about 0.5-50Hz (Hertz). Therefore, in order to meet the above-mentioned high voltage, high current and operating frequency conditions, the common electromagnetic stimulation equipment currently cannot be implemented using existing electronic transformers (Adapter), and can only use traditional linear transformers (transformers) as an implementation method. However, once this method is selected, the size and weight of the entire equipment will be limited by the design framework of the linear transformer, and the equipment cannot be miniaturized to be suitable for general home use. Therefore, for patients who need to frequently seek stimulation and improvement but can only be repeatedly moved to medical institutions, there are still many inconveniences in the current reality.

On the other hand, the prior art has also proposed some different types of electromagnetic stimulation devices, such as: (i) the type that sacrifices intensity, which is performed without the premise that the nerve can reach the action potential. Usually, this type of device cannot be classified as a formal electromagnetic stimulation device, but most of the electromagnetic stimulation devices currently used in hospitals belong to this type; (ii) the type that sacrifices frequency, which accumulates the stimulation intensity at a weaker charging speed, and the frequency will not exceed 0.2Hz. Although it is only applicable to indications that are also useful at extremely low frequencies, it is indeed a successful pioneer in miniaturizing electromagnetic stimulation devices. However, due to the limitations of the working and output conditions, it is not widely used in the field of electromagnetic stimulation. The adaptive symptoms improved by stimulation in the human body are limited; (iii) Frequency superposition replaces intensity type. Related research suggests that although low-intensity stimulation cannot directly cause biological effects, high-frequency continuous stimulation can produce effects due to the superposition of biological effects. Although the booster device of this type of equipment does not require too high a voltage, it must provide a large amount of current to supply the high-frequency output. Therefore, it will not use options other than traditional linear transformers, so it is still large in size and heavy in weight. To this day, even the most simple electromagnetic stimulation equipment still weighs about 20 kilograms, and in order to design this weight, corresponding safety devices or rollers must be matched to facilitate placement or movement. Taking a 2000-watt traditional linear transformer as an example, the total weight of the transformer alone is about 15 kilograms. The main reason for this is that the traditional linear transformer is basically composed of metal components. In other words, 75% of the weight of the entire electromagnetic stimulation device is due to the existence of this large iron block, which is indirectly one of the main reasons why electromagnetic stimulation devices are still difficult to popularize or even use at home.

In view of this, our team proposed a lightweight electromagnetic stimulation device and a booster device that is different from the known operation mode, which can boost the mains voltage to even more than 1 kilovolt, and then make the device output enough energy to drive the nerves to reach the action potential and maintain a frequency of more than 0.5Hz for continuous operation, so as to replace the traditional linear transformer and improve the above-mentioned shortcomings of the known technology.

The main purpose of this invention is to provide an electromagnetic stimulation device and a boost device thereof, which utilizes the electronic characteristics of two basic voltage doublers consisting of a current direction limiting element and two energy storage elements, and then realizes a multi-voltage rectification and boosting effect through a series or parallel design structure, thereby providing a high-voltage direct current sufficient to generate the required electromagnetic stimulation intensity, while maintaining the overall lightweight effect.

To achieve the above-mentioned purpose, the present invention discloses a multi-stage boosting device of an electromagnetic stimulation device, which is electrically connected to an external power source with a polarity periodic change for boosting output application, and is characterized in that: the multi-stage boosting device is formed by connecting a plurality of basic voltage multipliers, wherein the basic voltage multipliers respectively have a first current direction limiting element, a first energy storage element, a second current direction limiting element and a second energy storage element; the external power source is electrically connected to the basic voltage multipliers, and the first current direction limiting element and the first energy storage element of each basic voltage multiplier are electrically connected in series with the external power source, and the first current direction limiting element is connected in parallel with the second current direction limiting element having a current limiting direction opposite to the first current direction limiting element. The first current direction limiting element and the second current direction limiting element are connected in series with a second energy storage element so that the second energy storage element is located between the first current direction limiting element and the second current direction limiting element; wherein the first current direction limiting element and the second current direction limiting element of each basic voltage doubler are connected or disconnected according to the polarity of the input voltage, so as to switch the current direction so that the external power source charges the first energy storage element and the second energy storage element respectively in different cycles, and the charging process of the second energy storage element is provided by the external power source and the first energy storage element so that the cross-voltage of the second energy storage element is twice that of the first energy storage element, and the second energy storage elements of the basic voltage doublers are connected in series with each other for output application.

The first energy storage element and the second energy storage element are capacitors, inductors, batteries or a combination thereof. The first current direction limiting element and the second current direction limiting element are diodes, switches or a combination thereof. The second energy storage elements are connected in series to a DC voltage exceeding 700 volts.

In addition, the second purpose of this invention is to disclose an electromagnetic stimulation device, which includes: the multi-stage boost device as described above; and a stimulation unit electrically connected to the multi-stage boost device, thereby achieving the effect of stimulating human body movement after boosting.

The inductance value of the stimulation unit as the magnetic field output end is at least 1 microhenry (μH). The stimulation unit is formed by winding a copper wire coil or an aluminum wire coil. The surface of the stimulation unit generates a magnetic field exceeding 0.5 Tesla (T) at least once. The surface of the stimulation unit continuously generates a magnetic field exceeding 0.1 Tesla for more than 3 times and the time is less than 1 millisecond (ms).

In summary, the invention utilizes the electronic properties and arrangement structure of components such as diodes or switches and capacitors or inductors to boost the low voltage input from the external power source and convert it into a high voltage direct current that is sufficient to supply the stimulation unit with effective action potential. That is, the invention arranges the components in such a way that the first and second current direction limiting elements become conductive or non-conductive respectively according to the polarity of the input voltage, thereby switching the energy storage cycle time of the first and second energy storage elements, so that each second energy storage element presents a DC voltage with a cross-voltage twice the input peak voltage when the second energy storage element reaches steady-state charging, and further, the second energy storage elements are connected in series to form a stacked cross-voltage for output application. Accordingly, the multi-stage boosting device realizes a multiple voltage boosting function, which replaces the traditional linear transformer on the premise of ensuring that the stimulation unit outputs sufficient biological stimulation intensity, thereby achieving the effect of improving the overall equipment volume and weight. Furthermore, through the cross-voltage stacking structure of multiple second energy storage elements, the voltage stress that each energy storage element needs to withstand can be reduced, so that the cost of circuit components can be reduced and the circuit stability can be improved. Based on this, this invention breaks through the existing technical clichés and only uses common diodes or switches and capacitors or inductors as current direction limiting elements and energy storage elements, and through special electrical connection and integration, it can meet the conditions of medical-grade electromagnetic stimulation devices. At the same time, due to the selection of these components, it has a small size, light weight and fast charging and discharging speed to maintain a better operating frequency, and the total weight of the overall electromagnetic stimulation equipment can be lightweight.

1: Electromagnetic stimulation equipment

10: Multi-stage booster device

100: Basic voltage multiplier

1000: First current direction limiting element

1001: First energy storage element

1002: Second current direction limiting element

1003: Second energy storage element

11: Stimulation unit

2: External power supply

Figure 1 is a schematic diagram of the structure of a preferred embodiment of the multi-stage boost device of this invention connected to an external power source.

Figure 2 is a circuit diagram of a preferred embodiment of the multi-stage boost device of this invention connected to an external power source.

Figures 3A, 3B, 3C, and 3D are schematic diagrams of the cycle time charging operation of the preferred embodiment of the multi-stage boost device of the present invention connected to an external power source.

Figure 4 is a schematic diagram of the structure of a preferred embodiment of the electromagnetic stimulation device of the present invention connected to an external power source.

In order to enable people with general knowledge in this field to clearly understand the content of this work, please refer to the following explanation with diagrams.

Please refer to Figures 1 and 2, which are respectively a schematic diagram and a circuit diagram of a preferred embodiment of the multi-stage boost device of the present invention connected to an external power source. As shown in the figure, the multi-stage boost device 1 of the electromagnetic stimulation device is provided for electrically connecting an external power source 2 with a polarity periodic change for boosting output applications. The multi-stage boost device 1 is formed by connecting a plurality of basic voltage multipliers 100. Furthermore, the basic voltage multipliers 100 respectively have a first current direction limiting element 1000, a first energy storage element 1001, a second current direction limiting element 1002 and a second energy storage element 1003. The external power source 2 is electrically connected to the basic voltage multipliers 100, and the first current direction limiting element 1000 and the first energy storage element 1001 of each basic voltage multiplier 100 are electrically connected in series with the external power source 2. The first current direction limiting element 1000 is connected in parallel with the second current direction limiting element 1002 having a current limiting direction opposite to the first current direction limiting element 1000, and the second current direction limiting element 1002 is connected in series with a second energy storage element 1003 so that the second energy storage element 1003 is located between the first current direction limiting element 1000 and the second current direction limiting element 1002.

Based on the previous electrical structure, the first current direction limiting element 1000 and the second current direction limiting element 1002 of each basic voltage multiplier 100 are conductive or non-conductive according to the polarity of the input voltage, so as to switch the current direction so that the external power source 2 charges the first energy storage element 1001 and the second energy storage element 1003 respectively in different cycles, and the charging process of the second energy storage element 1003 is provided by the external power source 2 and the first energy storage element 1001 so that the voltage across the second energy storage element 1003 is twice that of the first energy storage element 1001. The second energy storage elements 1003 of the basic voltage multipliers 100 are connected in series with each other for output application. In other words, the number of basic voltage doublers 100 can be continuously expanded through the aforementioned electrical connection rules, and the voltage value suitable for terminal output application can be selected after voltage boosting.

In this embodiment, the first energy storage element 1001 and the second energy storage element 1003 are capacitors, inductors, batteries, or a combination thereof, and the first current direction limiting element 1000 and the second current direction limiting element 1002 are diodes, switches, or a combination thereof, so that the voltage across the second energy storage elements 1003 when connected in series is a direct current exceeding 700 volts (V). For example, as shown in FIG. 2, the basic voltage multipliers 100 can utilize the first energy storage elements 1001 and the second energy storage elements 1003 as capacitors, and the first current direction limiting elements 1000 and the second current direction limiting elements 1002 as diodes to form an eight-fold voltage multi-stage boost device 10, which includes the four basic voltage multipliers 100 described below:

1. The first basic voltage multiplier 100:

The two ends of the first first energy storage element 1001 ( _C1-1 ) are respectively coupled to one end of the external power source 2 and one end of the first first current direction limiting element 1000 ( _D1-1 ), and the other end of _D1-1 is coupled to the other end of the external power source 2. In this way, _D1-1 and _C1-1 are electrically connected to the external power source 2 to form a series loop; at the same time, the coupling point between _C1-1 and _D1-1 is further coupled to one end of the first second current direction limiting element 1002 ( _D2-1 ), and the other end of _D2-1 is coupled to one end of the first second energy storage element 1003 ( _C2-1 ). _D2-1 forms a circuit structure in which _D1-1 is connected in parallel and the current limiting directions are opposite to each other, and the other end of _C2-1 is coupled to the junction between _D1-1 and the external power source 2. In this way, D2 _-1 is connected in series with C2 _-1 and C2 _-1 is located between D1 _-1 and D2 _-1 . Accordingly, the first basic voltage doubler 100 of the double voltage boost circuit is formed. When the external power source 2 is a commercial power supply and provides a sinusoidal AC input with a peak voltage of Vm, the two ends of C2 _-1 have a voltage of 2Vm.

2. Connect the second basic voltage multiplier 100 to the first basic voltage multiplier 100:

The same circuit structure as above is used to form a second voltage doubling circuit connected in parallel with the first basic voltage doubler 100. The two ends of the second first energy storage element 1001 ( _C1-2 ) are respectively coupled to between the external power source 2 and _C1-1 and one end of the second first current direction limiting element 1000 ( _D1-2 ), and the other end of _D1-2 is coupled between the external power source 2 and _D1-1 ; at the same time, the coupling point between _C1-2 and _D1-2 is further coupled to one end of the second second current direction limiting element 1002 ( _D2-2 ), the other end of _D2-1 is coupled to one end of the second second energy storage element 1003 ( _C2-2 ), and the other end of _C2-2 is coupled between _C2-1 , _D1-1 and _D1-2 , so that the two ends of _C2-2 have a voltage of 2Vm.

3. Connect the third basic voltage multiplier 100 to the first basic voltage multiplier 100:

Continuously, the third double voltage circuit is formed. The two ends of the third first energy storage element 1001 ( _C1-3 ) are respectively coupled to _C1-1 , _D1-1 and _D2-1 and one end of the third first current direction limiting element 1000 ( _D1-3 ), and the other end of _D1-3 is coupled to _D2-1 and _C2-1 ; at the same time, the coupling point between _C1-3 and _D1-3 is further coupled to one end of the third second current direction limiting element 1002 ( _D2-3 ), the other end of _D2-3 is coupled to one end of the third second energy storage element 1003 ( _C2-3 ), and the other end of _C2-3 is coupled to _C2-1 , _D2-1 and _D1-3 , so that the two ends of _C2-3 have a cross voltage of 2Vm.

4. Connect the fourth basic voltage multiplier 100 to the second basic voltage multiplier 100:

The fourth double voltage circuit is completed. The two ends of the fourth first energy storage element 1001 ( _C1-4 ) are respectively coupled to _C1-2 , _D1-2 and _D2-2 and one end of the fourth first current direction limiting element 1000 ( _D1-4 ), and the other end of _D1-4 is coupled to _D2-2 and _C2-2 ; at the same time, the coupling point between _C1-4 and _D1-4 is further coupled to one end of the fourth second current direction limiting element 1002 ( _D2-4 ), the other end of _D2-4 is coupled to one end of the fourth second energy storage element 1003 ( _C2-4 ), and the other end of _C2-4 is coupled to _C2-2 , _D2-2 and _D1-4 , so that the two ends of _C2-4 have a cross voltage of 2Vm.

Accordingly, the voltage value output by the multi-stage boost device 10 is the voltage across the second energy storage elements 1003 of _C2-3 , _C2-1 , _C2-2 and _C2-4 connected in series, so the multi-stage boost device 10 can output a voltage value of 8Vm without taking into account the loss. Therefore, when the external power source is provided as AC 110V and the peak voltage Vm reaches 155VDC, the multi-stage boost device 10 can even output about 1200V of direct current after operation, thereby increasing the small voltage input by the external power source 2 to a high voltage that meets the requirements of the electromagnetic stimulation device 1.

Please refer to Figures 3A to 3D, which are schematic diagrams of the cycle time charging operation of the second preferred embodiment of the present invention. As shown in the figure, the AC voltage provided by the external power source 2 has a complete sine wave as a cycle (T) and has a sine wave cycle of T1+T2 and a negative sine wave cycle of T3+T4. Therefore, the charging operation process of the basic voltage multiplier 100 in each cycle time is as follows:

1. Figure 3A, T1 cycle time:

When the external power source 2 provides an AC voltage from 0 to the peak +Vm and gradually generates a voltage difference at the input end of the multi-stage boost device 10, _D2-1 and _D1-2 are turned on, so that the external power source 2, _C1-1 , _D2-1 and _C2-1 form a positive cycle charging loop L1 _-T1 , and at the same time, the external power source 2, _C1-2 and _D1-2 form a positive cycle charging loop L2 _-T1 . Accordingly, the current flows into _C1-1 , _C2-1 and _C1-2 until the end of the T1 cycle time, so that _C1-1 and _C2-1 store energy to half peak value and _C1-2 stores energy to peak value.

2. Figure 3B, T2 cycle time:

The external power source 2 provides an AC voltage that decreases from the peak +Vm to 0. At this time, _D1-3 and _D2-2 are turned on due to the device characteristics, so that the current flows from _C2-1 to _C1-3 and from _C1-2 to _C2-2 until the T2 cycle time ends, so that _C1-1 , _C2-1 , _C1-3 , _C1-2 and _C2-2 reach potential balance. In other words, during the T2 cycle time, when the voltage difference between the two input terminals of the multi-stage boost device 10 coupled to the external power source 2 is reduced, the external power source 2, _C1-1 , _C2-1 , _D1-3 and _C1-3 form a positive cycle balanced loop L1 _-T2 , and at the same time, the external power source 2, _C1-2 , _C2-2 and _D2-2 form a positive cycle balanced loop L2 _-T2 .

3. Figure 3C, during the T3 cycle:

When the external power source 2 provides an AC voltage that decreases from 0 to a peak-valley value of -Vm and a voltage difference is generated again at the two input terminals of the multi-stage boost device 10, _D1-1 and _D2-2 are turned on due to the device characteristics, so that the external power source 2, _C1-1 and _D1-1 form a negative cycle charging loop L1-T3. At the same time, the external power source 2, _C1-2 , _D2-2 and _C2-2 form a negative cycle charging loop L2 _{- T3} , thereby causing current to flow into _C1-1 , _C1-2 and _C2-2 , so that _C1-1 stores energy to the peak value and _C1-2 and _C2-2 store energy to the half peak value.

4. Figure 3D, during the T4 cycle:

The external power source 2 provides an AC voltage that increases from peak-valley -Vm to 0. At this time, _D1-3 and _D1-4 are turned on due to their device characteristics, so that the current flows from _C1-1 to _C1-3 and from _C2-2 to _C1-4 until the T4 cycle time ends, so that _C1-1 , _C1-3 , _C1-2 , _C2-2 and _C1-4 reach potential balance. In other words, during the T4 cycle, when the voltage difference at the input end of the multi-stage boost device 10 is reduced, the external power supply 2, _C1-1 , _C1-3 and _D1-3 form a negative cycle balancing loop L1 _-T4 , and at the same time, the external power supply 2, _C1-2 , _C2-2 , _D1-4 and _C1-4 form a negative cycle balancing loop L2 _-T4 .

It can be seen that as the period T1-T4 progresses, the first and second energy storage elements 1001 and 1003 in each of the basic voltage multipliers 100 will be sequentially stored to a stable state. In this way, the AC sine wave input by the external power source 2 is used to perform a cyclic charging action for a period of time T1~T4 until a stable state is reached, and the capacitor voltages of each of the first energy storage elements 1001 and each of the second energy storage elements 1003 will reach a balanced electrical energy, so that _C2-3 , _C2-1 , _C2-2 and _C2-4 are charged to twice the input peak voltage Vm, and the voltage value output by the multi-stage boost device 10 is the series cross-voltage of the second energy storage elements 1003: a DC voltage value of 8Vm. It is worth noting that even if a higher output voltage value is required due to actual circumstances, through the use of the basic voltage doublers 100 of the present invention, it is still easy to further connect and extend one, two or more basic voltage doublers 100 on the circuit of the existing multi-stage booster device 10, thereby expanding the voltage output capacity of the multi-stage booster device 10. Moreover, the eight-fold voltage boosting method achieved through the structure of such a series circuit can greatly reduce the voltage stress that each energy storage element needs to withstand, thereby reducing the overall circuit structure cost and achieving the effect of improving circuit stability.

Furthermore, another purpose of the invention is to use the aforementioned multi-stage booster device 10 to assemble an electromagnetic stimulation device 1 for use at home or in similar places. As shown in FIG4 , the electromagnetic stimulation device 1 is provided with the multi-stage booster device 10 and a stimulation unit 11, and the stimulation unit 11 is formed by winding a copper wire coil or an aluminum wire coil and is electrically connected to the multi-stage booster device 10 to capture the DC voltage value output by the multi-stage booster device 10 to form an actuating power. It is worth noting that in order for the electromagnetic stimulation device 1 to present a better improvement effect, the cross-voltage value output provided by the multi-stage booster device 10 is supplemented, and the inductance value of the stimulation unit 11 as the magnetic field output end is set to at least 1 microhenry (μH), and the surface of the stimulation unit 11 generates a magnetic field exceeding 0.5 Tesla (T) at least once; or, the surface of the stimulation unit 11 continuously generates a magnetic field exceeding 0.1 Tesla for more than 3 times and the time is less than 1 millisecond (ms), thereby improving the adaptability of the human body. Specifically, the stimulation unit 11 can be released after being fully charged through the energy storage device connected to the front end, thereby achieving a very large current change, and used to generate the corresponding stimulation magnetic field specifications as described above.

In summary, the invention utilizes the electronic properties and arrangement structure of components such as diodes or switches and capacitors or inductors to boost the low voltage input from the external power source and convert it into a high voltage direct current that is sufficient to supply the stimulation unit with effective action potential. That is, the invention arranges the components in such a way that the first and second current direction limiting elements become conductive or non-conductive respectively according to the polarity of the input voltage, thereby switching the energy storage cycle time of the first and second energy storage elements, so that each second energy storage element presents a DC voltage with a cross-voltage twice the input peak voltage when the second energy storage element reaches steady-state charging, and further, the second energy storage elements are connected in series to form a stacked cross-voltage for output application. Accordingly, the multi-stage boosting device realizes a multiple voltage boosting function, which replaces the traditional linear transformer on the premise of ensuring that the stimulation unit outputs sufficient biological stimulation intensity, thereby achieving the effect of improving the overall equipment volume and weight. Furthermore, through the cross-voltage stacking structure of multiple second energy storage elements, the voltage stress that each energy storage element needs to withstand can be reduced, so that the cost of circuit components can be reduced and the circuit stability can be improved. Based on this, this invention breaks through the existing technical ruts and only uses common diodes or switches and capacitors or inductors as current direction limiting elements and energy storage elements, and can meet the conditions of medical-grade electromagnetic stimulation devices through special electrical connection and integration. At the same time, due to the selection of these components, it has a small size, light weight and fast charging and discharging speed to maintain a better operating frequency, and the total weight of the overall electromagnetic stimulation equipment can be reduced.

The above is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Therefore, all equivalent changes and modifications made without departing from the spirit and scope of the present invention should be included in the patent scope of the present invention. Moreover, in the description of the present application, it should be noted that the terms "first", "second", etc. are only used to distinguish the description, and cannot be understood as indicating or implying relative importance. It should also be noted that, unless otherwise clearly specified and limited, the terms "set" and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, or it can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present application can be understood in specific circumstances.

1: Electromagnetic stimulation equipment

10: Multi-stage booster device

100: Basic voltage multiplier

1000: First current direction limiting element

1001: First energy storage element

1002: Second current direction limiting element

1003: Second energy storage element

11: Stimulation unit

2: External power supply

Claims (9)

A multi-stage boost device for an electromagnetic stimulation device is provided for electrically connecting an external power source with a periodic change in polarity for boosting output application, and its characteristics are: The multi-stage boost device is formed by connecting a plurality of basic voltage multipliers, wherein the basic voltage multipliers respectively have a first current direction limiting element, a first energy storage element, a second current direction limiting element and a second energy storage element; the external power source is electrically connected to the basic voltage multipliers, and the first current direction limiting element and the first energy storage element of each basic voltage multiplier are electrically connected in series with the external power source, and the first current direction limiting element is connected in parallel with the second current direction limiting element having a current limiting direction opposite to the first current direction limiting element, and the second current direction limiting element is connected in series with a second energy storage element so that the second energy storage element Located between the first current direction limiting element and the second current direction limiting element; wherein the first current direction limiting element and the second current direction limiting element of each basic voltage doubler are conductive or non-conductive according to the polarity of the input voltage, so as to switch the current direction so that the external power source charges the first energy storage element and the second energy storage element respectively in different cycles, and the charging process of the second energy storage element is provided by the external power source and the first energy storage element so that the cross-voltage of the second energy storage element is twice that of the first energy storage element, and the second energy storage elements of the basic voltage doublers are connected in series with each other for output application. A multi-stage boost device as claimed in claim 1, wherein the first energy storage element and the second energy storage element are capacitors, inductors, batteries or a combination thereof. A multi-stage boost device as claimed in claim 1, wherein the first current direction limiting element and the second current direction limiting element are diodes, switches or a combination thereof. A multi-stage boost device as claimed in claim 1, wherein the second energy storage elements are connected in series to provide a DC voltage exceeding 700 volts (V). An electromagnetic stimulation device, comprising: A multi-stage boost device as described in any one of claims 1 to 4; and A stimulation unit electrically connected to the multi-stage boost device. For example, in the electromagnetic stimulation device of item 5 of the patent application scope, the inductance value of the stimulation unit as the magnetic field output end is at least 1 microhenry (µH). For example, in the electromagnetic stimulation device of item 5 of the patent application, the stimulation unit is formed by winding a copper wire coil or an aluminum wire coil. For example, in the electromagnetic stimulation device of item 5 of the patent application, the surface of the stimulation unit generates a magnetic field exceeding 0.5 Tesla (T) at least once. For example, the electromagnetic stimulation device of item 5 of the patent application scope, wherein the surface of the stimulation unit continuously generates a magnetic field exceeding 0.1 Tesla more than 3 times and the time is less than 1 millisecond (ms).