TWM615753U - Gene delivery device - Google Patents

Abstract

The present model provides a gene delivery device, which mainly includes a pressure accumulation unit, an output tube body, and an adapter tube body, wherein the adapter tube body is used to sleeve and connect the pressure accumulation unit and the output tube body, so that the output tube body is The connection port is connected to the output part of the pressure accumulation unit. The inner surface of the adapter tube body includes at least one engaging groove, and the outer surface of the output tube body is provided with at least one connecting protrusion, wherein the connecting protrusion of the output tube body can be engaged in the engaging groove of the adapter tube body , In order to fix the output tube body on the adapter tube body, and achieve the purpose of quickly disassembling and connecting the output tube body.

Description

Gene delivery device

The invention relates to a gene delivery device, which connects a pressure accumulating unit and an output tube body through an adapter tube body, so as to achieve the purpose of quickly disassembling and connecting the output tube body.

The gene gun is a gene transfer device, which mainly attaches DNA to the surface of metal particles, such as tungsten or gold powder, and accelerates the metal particles through high-pressure gas, so that the metal particles with DNA are ejected and can penetrate the skin tissue, cell wall or The cell membrane, which in turn transports DNA into the cell. At present, gene guns are widely used in the fields of gene transfer of animals and plants, DNA vaccines, gene therapy and medical beauty.

Gene gun can use gunpowder explosion, high voltage or high pressure gas as a power source to accelerate metal particles. The structure of the gene gun currently in use is complicated, which not only increases the cost and difficulty of production, but also may cause the high-pressure gas produced due to the poor quality of the gene gun to easily form a gas turbulence, thereby affecting the effect of gene transfer.

The above-mentioned power source may push the gene gun during use, and easily cause the gene gun to loosen or fall. In addition, in actual use, it is often necessary to change different gene guns due to different users to avoid the problem of cross-infection.

For this reason, the present invention proposes a gene delivery device. Through the use of the transfer tube body, the output tube body can be quickly set on the pressure accumulation unit, or the output tube body can be removed from the pressure accumulation unit to improve the use time. Convenience.

An object of the present invention is to provide a gene delivery device, which mainly includes a pressure accumulation unit, an adapter tube body and an output tube body, wherein the output tube body is connected to the pressure accumulation unit through the adapter tube body. One end of the adapter tube body is sleeved on the output part of the pressure accumulation unit, and the other end is sleeved on the output tube body. In addition, the inner surface of the adapter tube body is provided with at least one engaging groove, and the outer surface of the output tube body is provided with at least one corresponding connecting protrusion, wherein the connecting protrusion is used for engaging in the engaging groove to hold the output tube The body is fixed on the adapter tube body, and it can prevent the output tube body from loosening during use.

An object of the present invention is to provide a gene delivery device, which is mainly provided with at least one guiding groove on the inner surface of the adapter tube body, wherein the guiding groove is connected to the engaging groove. When the output tube body is inserted into the accommodating space of the adapter tube body, the connecting convex portion provided on the outer surface of the output tube body will be guided to the engaging groove by the guiding groove. Then, the output tube body can be rotated relative to the adapter tube body, so that the connecting convex portion is locked in the locking groove, so as to complete the connection between the output tube body and the adapter tube body.

An object of the present invention is to provide a gene delivery device, which is mainly provided with a partition unit inside an output tube body, wherein the partition unit divides an accommodating space in the output tube body into a pressure accumulation space and an ejection space. The first surface of the partition unit and the inner tube wall of the output tube body form a constriction at one end of the pressure accumulation space, and the second surface of the partition unit and the inner tube wall of the tube body form an expansion part at one end of the spray space. When the gas passes through the constriction, the speed will gradually increase, and the high-speed gas generated can drive the metal particles with DNA or project the DNA solution onto the target.

To achieve the above object, the present invention provides a gene delivery device, which includes: a pressure accumulating unit including an output part, wherein the pressure accumulating unit outputs a pressure accumulating gas through the output part; an output tube body including a connection port and at least one connection A convex portion and an ejection port, wherein the connection port and the ejection port are respectively located at both ends of the output pipe body, and the connecting convex portion is located on an outer surface of the output pipe body; and an adapter pipe body including a first connection end, A second connecting end and at least one engaging groove. The first connecting end and the second connecting end are respectively located at both ends of the adapter tube body, and the engaging groove is located on an inner surface of the adapter tube body, wherein the first connection The end is sleeved on the output part of the pressure accumulation unit, and the connection port of the output tube body enters the adapter tube body from the second connection end, and is connected to the output part of the pressure accumulation unit through the adapter tube body, and the connecting convex part of the output tube body Then it is locked in the locking groove of the adapter tube body.

In the gene delivery device, the inner surface of the adapter tube body includes at least one guiding groove connecting engaging groove, and is used for guiding the connecting convex part of the output tube body into the engaging groove.

In the gene delivery device, a width of the guiding groove is gradually reduced from the second connecting end of the adapter tube toward the first connecting end.

In the gene delivery device, the output tube body includes an accommodating space located between the connection port and the ejection port, and the outer surface of the output tube body is provided with a feed hole connecting the accommodating space.

In the gene delivery device, the adapter tube body includes a perforation, and when the connecting protrusion of the output tube body is engaged with the engaging groove of the adapter tube body, the perforation of the adapter tube body will be aligned with the inlet of the output tube body. Material hole.

In the gene delivery device, a fixing groove is arranged on the output part, and a connecting hole of the adapter tube body is inserted through a latch unit to be clamped in the fixing groove.

In the gene delivery device, the output tube body includes an inner tube wall, an accommodating space is formed between the inner tube wall, the connection port and the ejection port, and a partition unit is arranged in the accommodating space, A first surface of the partition unit faces the connection port of the pipe body, the space between the first surface and the inner tube wall gradually shrinks from the connection port toward the ejection outlet, and a second surface of the partition unit faces the pipe The space between the second surface of the body and the inner tube wall gradually increases from the connection port to the direction of the ejection port.

In the gene delivery device, the connection port of the output tube body is provided with a convex part, and the output part of the pressure accumulation unit is provided with a concave part. When the output tube body is connected to the pressure accumulation unit, the convex part of the connection port will be inserted into the output part.内内。 In the recess.

10: Gene delivery device

11: Pressure accumulation unit

111: output section

113: fixed slot

13: Adapter body

131: first connection end

1311: connecting hole

132: Latch unit

133: second connection end

135: snap slot

137: Guiding Groove

139: Piercing

15: output tube body

151: connection port

152: accommodating space

153: Ejector

154: inner tube wall

155: Connecting convex part

157: Separating unit

1571: First Surface

1573: Second Surface

159: feed hole

[Figure 1] is a three-dimensional exploded schematic diagram of an embodiment of the novel gene delivery device.

[Figure 2] is an exploded schematic diagram of a side view of an embodiment of the novel gene delivery device.

[Figure 3] is an exploded top view of an embodiment of the novel gene delivery device.

[Figure 4] is a side view combination diagram of an embodiment of the novel gene delivery device.

[Figure 5] is a side sectional view of an embodiment of the output tube body of the novel gene delivery device.

[Figure 6] is a three-dimensional exploded schematic diagram of another embodiment of the novel gene delivery device.

Please refer to Figure 1, Figure 2, Figure 3 and Figure 4, which are respectively a three-dimensional exploded schematic view, a side exploded schematic view, a top exploded schematic view, and a side combined view of an embodiment of the novel gene delivery device. As shown in the figure, the gene delivery device 10 mainly includes a pressure accumulation unit 11, a transfer tube body 13 and An output tube body 15 in which the adapter tube body 13 is used to connect the pressure accumulation unit 11 and the output tube body 15 and is located between the pressure accumulation unit 11 and the output tube body 15.

The pressure accumulating unit 11 includes an output part 111 and outputs a pressure accumulating gas through the output part 111. Specifically, the pressure accumulation unit 11 includes a pressure accumulation chamber and at least one valve. The pressure accumulation chamber is fluidly connected to a gas cylinder through a valve. The gas pressure is greater than the outside, for example, greater than one atmosphere. The pressure accumulating chamber is also connected to the output part 111 through another valve. When the valve is opened, the pressure accumulating gas in the pressure accumulating chamber will be output from the pressure accumulating unit 11 by the output part 111.

The output tube body 15 includes a connecting port 151, a spray outlet 153, and at least one connecting convex portion 155. The connecting port 151 and the spray outlet 153 are respectively located at both ends of the output tube body 15, and the connecting convex portion 155 is located on the output tube body 15.的一外面。 An outer surface.

The connection port 151 of the output pipe 15 is used to connect the output portion 111 of the pressure accumulation unit 11, wherein the pressure accumulation gas output by the output portion 111 of the pressure accumulation unit 11 will enter the connection port 151 of the output pipe body 15 and be passed through the output pipe body 15 The ejection port 153 of 15 ejects. The pressurized gas will be accelerated when passing through the output pipe body 15 and high-speed gas will be ejected from the ejection port 153. In an embodiment of the present invention, the output portion 111 includes a concave portion, and the connection port 151 includes a convex portion. When the connection port 151 is connected to the output portion 111, the convex portion of the connection port 151 will be inserted into the concave portion of the output portion 111.

In an embodiment of the present invention, as shown in FIG. 5, the output tube body 15 includes an accommodating space 152 located between the connection port 151 and the ejection port 153. Specifically, the accommodating space 152 can be formed by the connection port 151 and the ejection port 153. 153 and the inner tube wall 154. A partition unit 157 is disposed in the accommodating space 152 of the output tube body 15, wherein the partition unit 157 is used to divide the accommodating space 152 into two connected spaces. The separating unit 157 may be spindle-shaped and includes at least one first surface 1571 and at least one first surface 1571 Two surfaces 1573, of which the first surface 1571 faces the connection port 151 of the output tube body 15, and the space between the first surface 1571 and the inner tube wall 154 of the output tube body 15 is gradually reduced from the connection port 151 to the direction of the ejection outlet 153 , While the second surface 1573 faces the ejection port 153 of the output tube body 15, the space between the second surface 1573 and the inner tube wall 154 of the output tube body 15 gradually increases from the connection port 151 toward the ejection port 153. Through the design of the output pipe body 15 described above, the speed of the pressure-accumulated gas transmitted from the connection port 151 to the ejection port 153 can be accelerated.

The output pipe body 15 further includes a feed hole 159, wherein the feed hole 159 is provided on the outer surface of the output pipe body 15 and is fluidly connected to the accommodating space 152 of the output pipe body 15. The DNA solution or metal particles with DNA can be transported into the accommodating space 152 through the feed hole 159. When the pressurized gas is transferred from the connection port 151 to the ejection port 153, it will drive the DNA solution or metal particles with DNA in the containing space 152 to move to the ejection port 153, and the gene delivery device 10 will be ejected from the ejection port 153. The above-mentioned structure of the output pipe body 15 is only a specific embodiment of the present invention, and is not a limitation of the scope of the rights of the present invention.

The adapter tube body 13 includes a first connection end 131, a second connection end 133 and at least one engaging groove 135, wherein the first connection end 131 and the second connection end 133 are respectively located at two ends of the adapter tube body 13. The engaging groove 135 is located on an inner surface of the adapter tube body 13.

The adapter tube body 13 can be sleeved on the output part 111 of the pressure accumulation unit 11, and is sleeved on a part of the output tube body 15 through the connecting port 151 to connect and fix the pressure accumulation unit 11 and the output tube body 15. In practical applications, the first connecting end 131 of the adapter tube body 13 can be sleeved on the output portion 111 of the pressure accumulation unit 11, and the adapter tube body 13 can be fixed on the pressure accumulation unit 11 through at least one fixing screw.

In an embodiment of the present invention, a fixing groove 113 may be provided on the output portion 111, wherein the fixing groove 113 is located between the output portion 111 and the body of the pressure accumulation unit 11. An end of the adapter tube 13 close to the first connecting end 131 may be provided with a connecting hole 1311. When the first connecting end 131 of the adapter tube 13 is sleeved on the output part 111, the connecting hole 1311 on the adapter tube 13 Will overlap with the fixing groove 113 of the accumulating unit 11, and then a latch unit 132 can be inserted through the connecting hole 1311 of the adapter tube body 13 and clamped in the fixing groove 113 to fix the adapter tube body 13 in On the pressure accumulation unit 11.

The connection port 151 of the output pipe body 15 enters the adapter pipe body 13 from the second connection end 133, and guides the output pipe body 15 through the adapter pipe body 13, so that the connection port 151 of the output pipe body 15 is connected to the output of the pressure accumulation unit 11. Then, the connecting convex portion 155 of the output tube body 15 is engaged with the engaging groove 135 of the adapter tube body 13 to fix the output tube body 15 on the adapter tube body 13. There may be one connecting protrusion 155 and engaging groove 135, and preferably two.

In an embodiment of the present invention, the output tube body 15 can be rotated relative to the adapter tube body 13 so that the connecting protrusion 155 of the output tube body 15 is engaged with the engaging groove 135 of the adapter tube body 13. For example, the engaging groove 135 may be a long groove or perforation provided on the inner surface of the adapter tube body 13, wherein the long end of the engaging groove 135 is perpendicular to the axial direction of the adapter tube body 13.

In an embodiment of the present invention, the adapter tube body 13 may include at least one guiding groove 137 connected to the engaging groove 135, wherein the guiding groove 137 is used to guide the connecting protrusion 155 of the output tube body 15 into the engaging groove 135. The width of the guiding groove 137 can be gradually reduced from the second connecting end 133 of the adapter tube body 13 toward the first connecting end 131, and is used to guide the connecting protrusion 155 of the output tube body 15 to the engaging groove 135.

When the output tube body 15 is inserted into the adapter tube body 13 through the second connecting end 133, the feed hole 159 on the output tube body 15 may be blocked by the adapter tube body 13. Therefore, a The perforation 139, when the connecting convex portion 155 of the output tube body 15 is engaged with the engaging groove 135 of the adapter tube body 13, the perforation 139 of the adapter tube body 13 will be aligned with the feed hole 159 of the output tube body 15.

In another embodiment of the present invention, as shown in FIG. 6, the length of the adapter tube body 13 can be shortened, so that the output tube body 15 will not cover the feed hole of the output tube body 15 when the adapter tube body 13 is connected. 159, and there is no need to provide perforations 139 on the adapter tube body 13.

The above is only one of the preferred embodiments of the present invention, and is not intended to limit the scope of implementation of the present invention, that is, all the equivalent changes and changes in the shape, structure, characteristics and spirit described in the scope of the patent application of the present invention Modifications should be included in the scope of the patent application for this new model.

10: Gene delivery device

11: Pressure accumulation unit

111: output section

113: fixed slot

13: Adapter body

131: first connection end

1311: connecting hole

132: Latch unit

133: second connection end

139: Piercing

15: output tube body

151: connection port

153: Ejector

155: Connecting convex part

159: feed hole

Claims (8)

A gene delivery device includes: a pressure accumulation unit, including an output portion, wherein the pressure accumulation unit outputs a pressure accumulation gas through the output portion; an output tube body, including a connection port, at least one connection protrusion, and an ejection port , Wherein the connecting port and the ejection port are respectively located at both ends of the output tube body, and the connecting convex portion is located on an outer surface of the output tube body; and an adapter tube body including a first connecting end, a A second connecting end and at least one engaging groove, the first connecting end and the second connecting end are respectively located at two ends of the adapter tube body, and the engaging groove is located on an inner surface of the adapter tube body, Wherein the first connection end is sleeved on the output part of the pressure accumulation unit, and the connection port of the output pipe body enters the adapter pipe body from the second connection end, and is connected to the accumulator via the adapter pipe body. The output portion of the pressing unit and the connecting convex portion of the output tube body are engaged with the engagement groove of the adapter tube body. The gene delivery device according to claim 1, wherein the inner surface of the adapter tube body includes at least one guiding groove connected to the engaging groove, and used for guiding the connecting convex portion of the output tube body into the engaging groove . The gene delivery device according to claim 2, wherein a width of the guiding groove gradually decreases from the second connecting end of the adapter tube toward the first connecting end. The gene delivery device according to claim 2, wherein the output tube body includes an accommodating space located between the connection port and the ejection port, and a feed hole is provided on the outer surface of the output tube body to connect the Housing space. The gene delivery device according to claim 4, wherein the adapter tube body includes a perforation, and when the connecting protrusion of the output tube body is engaged with the engaging groove of the adapter tube body, the adapter tube body The perforation is aligned with the feed hole of the output pipe body. The gene delivery device according to claim 1, wherein a fixing groove is provided on the output part, and a connecting hole of the adapter tube body is inserted through a latch unit to be clamped in the fixing groove. The gene delivery device according to claim 1, wherein the output tube body includes an inner tube wall, an accommodating space is formed between the inner tube wall, the connecting port, and the ejection port, and is disposed in the accommodating space A partition unit, wherein a first surface of the partition unit faces the connection port of the pipe body, and the space between the first surface and the inner tube wall gradually decreases from the connection port toward the ejection port, and A second surface of the partition unit faces the ejection port of the tube body, and the space between the second surface and the inner tube wall gradually increases from the connection port toward the ejection port. The gene delivery device according to claim 1, wherein the connecting port of the output tube body is provided with a convex part, and the output part of the pressure accumulating unit is provided with a concave part, and when the output tube body is connected to the pressure accumulating unit, The convex part of the connecting port is inserted into the concave part of the output part.

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