TWM548933U - Bluetooth wireless transmission system for brain electrochemical signals - Google Patents

Description

Bluetooth electronic transmission system for brain electrochemical signals

This creation is a Bluetooth wireless transmission system for brain electrochemical signals, especially a Bluetooth wireless transmission system for brain electrochemical signals with Bluetooth devices.

The conventional brain electrochemical signal monitoring device is connected with a transmission line between the sensing probe and the electrochemical signal recorder, and uses the transmission line to transmit the electrochemical signal of the living animal detected by the sensing probe in the living animal brain. Enlarged and recorded in a recorder at a distance from the animal. When the transmission line is shaken by external force, it is easy to form an electrochemical signal that the noise affects the transmission, so that the computer cannot receive the noise or the electrochemical signal when receiving the signal.

In addition, the transmission line sway and the loading and unloading connection lines also cause the head electrode of the experimental animal to shake, causing secondary damage to the brain of the experimental animal. Therefore, if the transmission line to be connected to the conventional brain electrochemical signal monitoring device can be eliminated, the discomfort caused by connecting the transmission line to the experimental animal can be reduced, and the above experimental error can be reduced. Wireless transmission can effectively solve the negative impact of the transmission line, but the power supply problem will be a big problem.

In the experiment, we will implant the Bluetooth wireless transmission system of the brain electrochemical signal into the animal. When the power consumption needs to be replaced, the system must be re-operated to remove the power supply and then re-implanted into the animal. This is very experimental. The big challenge is because we can't ensure the impact of the re-implantation process, including; secondary damage to experimental animals, changes in experimental conditions (measured in different locations).

When traditionally performing current stimulation, we control the beginning and end of electrical stimulation, but Yes, if the system malfunctions or the wireless receiver is abnormal and the external control stimulation current cannot be stopped, the system must be surgically removed and the power supply turned off to stop the stimulation current. If the system abnormality is not detected and the operation is performed, then the experimental animal is Words will be a big hurt. Therefore, a safety device that stimulates current is an important design for protecting experimental animals.

This creation is a fast scanning cyclic voltammetry method that realizes wireless, reduces the impact of device installation (transplantation) on the normal physiology and activities of experimental animals, and interferes with the removal of noise generated by signal lines. Currently related technologies for wireless transmission and Limited and expensive, it takes tiny DA signals and suppresses noise to ensure signal quality. Combine the record with the current stimulator to avoid the interference between the two systems (usually rare technology).

This creation features a protective device that incorporates a stimulation and recording system with a current stimulator. When the wireless receiver fails, the current stimulator is quickly turned off to reduce damage to the experimental animals. When the microcontroller does not receive the start signal from the computer, it will automatically close the non-essential area, retain only the Bluetooth transmission device and the wake-up device, and reduce the energy consumption of standby energy consumption. The signal end intercepts the low-noise micro-dopamine signal, and the advantage of Bluetooth makes the circuit easy to communicate with the mobile device in the future.

The present invention provides a wireless transmission probe system, comprising: a stimulation module comprising a voltage/current converter, and a stimulation terminal electrically connected to an output of the voltage/current converter; a recording module The utility model comprises a volt-ampere analog front pole and a recording terminal electrically connected to the input end of the volt-ampere analog front pole; a control module for controlling the voltage/current converter by a stimulation process, and a recording process To control and receive the volt-ampere analog output signal of the front pole; and a wireless module electrically connected to the control module to transmit/receive signals in both directions.

With the implementation of this creation, the following advancements can be achieved:

1. It can improve the problem that the traditional recording method is easily affected by the signal transmission line.

2. Separate recording systems require additional stimulation systems.

3. Tiny DA signals (number nA) are susceptible to noise.

In order to enable any skilled artisan to understand the technical content of the present invention and implement it according to the contents, patent application scope and drawings disclosed in the specification, any skilled person can easily understand the purpose and advantages of the present invention. Therefore, the detailed features and advantages of the present invention will be described in detail in the embodiments.

10‧‧‧With wireless transmission probe system structure

11‧‧‧ brain

20‧‧‧Control Module

30‧‧‧Wireless Module

40‧‧‧DAC

50‧‧‧ADC

60‧‧‧Stimulus module

61‧‧‧Voltage/Current Converter

70‧‧‧recording module

71‧‧‧ volt-ampere analog front pole

72‧‧‧recording terminal

73‧‧‧carbon fiber

74‧‧‧Micro glass tube

75‧‧‧ mixed solution

76‧‧‧Stainless steel tube

100‧‧‧Manual current stimulation at the wireless Bluetooth receiver

110‧‧‧current stimulation

120‧‧‧Determination of signal size

130‧‧‧Stop current stimulation wave

[Fig. 1] is a diagram of a wireless transmission probe system of the present invention; [Fig. 2] is a partially enlarged view of the carbon fiber electrode structure of the recording end probe of the present invention; and [Fig. 3] Stimulation probe animal protection device flow chart.

In order to facilitate your review committee to have a better understanding and understanding of the technical means and operation process of this creation, the following examples are combined with the drawings, which are described in detail below.

As shown in FIG. 1 , the embodiment provides a Bluetooth wireless transmission system 10 for brain electrochemical signals, comprising: a control module 20, wherein a wireless module 30, a DC-to-AC converter DAC 40, and an AC-DC conversion are provided. The ADC 50, the stimulation module 60, and a recording module 70.

The wireless transmission probe system structure 10 is mainly used for accommodating the control module 20, and is electrically connected to the output end of the DC/AC converter 40; the output end is electrically connected to a stimulation module 60, and the stimulation module 60 includes a voltage/current converter 61, and a stimulation terminal 62; the stimulation terminal is inserted into the brain 11 of the animal.

The stimulation module 60 includes a voltage/current converter 61 and a stimulation terminal 62 electrically connected to the output of the voltage/current converter 61. The stimulation terminal can be an electrode or a fiber structure.

The recording module 70 includes a volt-ampere analog front pole 71 and a recording terminal 72 electrically connected to the input end of the volt-ampere analog front pole 71. The recording terminal may be a carbon fiber microelectrode structure. The carbon fiber microelectrode structure may include: a stainless steel tube 76; a micro glass tube 74 installed in the stainless steel tube 76; and a carbon fiber 73 penetrating in the micro glass tube 74 and protruding from one side of the stainless steel tube 76. unit. The diameter of the carbon fiber is not more than 8μ

The control module 20 controls the voltage/electrical converter 61 by a stimulation process, and controls and receives the output signal of the volt-ampere analog front pole 71 by a recording process; the control module 20 can have a standby mode; When the control module 20 does not receive the signal output from the recording terminal 72 for a long time, the non-essential circuit area is automatically turned off, and the standby energy consumption is reduced.

The stimulation process includes: receiving an indication signal for starting the stimulation; generating a current stimulation wave and performing the stimulation; and the stimulation is performed or stopped again, and determining whether to generate the current stimulation wave according to the size of the reflection signal received by the recording module 70. stimulate. The stimulation process may further include a step of cutting off the stimulation current, and when determining that the wireless module 30 is abnormal, performing the cutting stimulation current

The above recording process includes: providing a scan wave by the control module 20 to provide a scan wave to the volt-ampere analog front pole 71; and extracting a signal, which receives a reflected signal by the scan wave capture recording terminal 72. .

The control module 20, the output end of the DC/AC converter 40, is electrically connected to a recording module 70, which includes a volt-ampere analog front pole 71, and a recording terminal 72. The recording module 70 is electrically connected to The volt-ampere is analogous to the input of the front pole 71.

The wireless module 30 is electrically connected to the control module 20 to transmit/receive signals in two directions. The wireless module can be a Bluetooth wireless module or a ZigBee wireless module.

As shown in FIG. 2, it is a detailed structure of a recording module 70, wherein the carbon fiber microelectrode structure comprises: a stainless steel tube 76; a tapered micro glass tube 74 installed in the stainless steel tube and a carbon fiber 73, worn It is disposed in the micro glass tube 74 and protrudes from one side end portion of the stainless steel tube 76. The stainless steel tube 76 is a hollow cylinder having a diameter of 20 to 50 μ. A conical microglass tube 74 is filled with a mixed solution 75 prepared by mixing 4 M potassium acetate with 150 mM potassium chloride.

As shown in FIG. 3, the animal protection current structure 100 of the stimulation probe module 60 is controlled by the animal brain electrochemical detection experimenter to control the stimulation current into the brain of the test animal and the related parameter 110, and To monitor the signal size 120 after passing through the current meter at the control wafer, when less than the threshold value, the current stimulus 130 is stopped to protect the animal to be tested.

However, the above embodiments are intended to illustrate the features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the contents of the present invention and to implement it, and not to limit the scope of the patent of the present invention. Equivalent modifications or modifications made by the spirit of the disclosure should still be included in the scope of the claims described below.

10‧‧‧With wireless transmission probe system structure

11‧‧‧ brain

20‧‧‧Control Module

30‧‧‧Wireless Module

40‧‧‧DAC

50‧‧‧ADC

60‧‧‧Stimulus module

61‧‧‧Voltage/Current Converter

62‧‧‧Stimulus terminals

70‧‧‧recording module

71‧‧‧ volt-ampere analog front pole

72‧‧‧recording terminal carbon fiber microelectrode

Claims (10)

A Bluetooth wireless transmission system for brain electrochemical signals, comprising: a stimulation module comprising a voltage/current converter, and a stimulation terminal electrically connected to an output end of the voltage/current converter; a group comprising a volt-ampere analog front pole and a recording terminal electrically connected to the input end of the volt-ampere analog front pole; a control module for controlling the voltage/current converter by a stimulation process, A recording process is used to control and receive the output signal of the volt-ampere analog front pole; and a wireless module is electrically connected to the control module to transmit/receive signals in both directions. The Bluetooth wireless transmission system of claim 1, wherein the stimulation terminal is an electrode or a fiber structure. The Bluetooth wireless transmission system of claim 1, wherein the recording terminal is a carbon fiber microelectrode structure. The Bluetooth wireless transmission system of claim 3, wherein the carbon fiber microelectrode structure comprises: a stainless steel tube; a micro glass tube installed in the stainless steel tube; and a carbon fiber disposed through the micro The inside of the glass tube protrudes from one side end of the stainless steel tube. The Bluetooth wireless transmission system of claim 4, wherein the carbon fiber has a diameter of not more than 8 μ. The Bluetooth wireless transmission system of claim 1, wherein the stimulation process comprises: receiving an indication signal to start stimulation; generating a current stimulation wave and performing stimulation; and exciting or stopping the stimulation, receiving according to the recording module. The size of the reflected signal determines whether or not to generate the current stimulation wave and perform the stimulation again. The Bluetooth wireless transmission system of claim 6, further comprising a step of cutting off the stimulation current, and when determining that the wireless module is abnormal, performing a cut-off stimulation current. The Bluetooth wireless transmission system of claim 1, wherein the recording process comprises: providing a scanning wave, wherein the control module provides a scanning wave to the volt-ampere analog front pole; and extracting a signal, Receiving, by the scanning wave, the recording terminal receives a reflected signal. The Bluetooth wireless transmission system of claim 1, wherein the wireless module is a Bluetooth wireless module or a ZigBee wireless module. The Bluetooth wireless transmission system of claim 1, wherein the control module has a standby mode; when the control module does not receive the signal output by the recording terminal for a long time, the non-essential circuit area is automatically turned off. Reduce standby energy consumption.