TWM535807U - Detecting device - Google Patents
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Abstract
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本創作是關於一種檢測裝置,特別是關於一種利用自體螢光影像進行檢測的檢測裝置。The present invention relates to a detecting device, and more particularly to a detecting device that performs detection using an autofluorescent image.
根據衛生福利部在2012年的死因統計,連續32年以來,惡性腫瘤為台灣死因之首,而癌症發生與死亡人數最多的前5大癌症,分別為大腸癌、肝癌、肺癌、乳癌、口腔癌(含口咽、下咽)。以口腔癌為例,其顯然與台灣人嚼食檳榔與吸菸之習性脫離不了關係。口腔癌好發於檳榔嚼食相關的頰黏膜與下齒齦部位,病人往往等到疼痛、腫塊或顏面變形等症狀就醫時多已進入晚期,五年存活率相較於早期癌症減少了一半以上。若在口腔癌發生的早期能提早診斷出並施以適當的治療,就能降低死亡率,因此早期篩檢口腔癌勢必為重要議題。According to the death statistics of the Ministry of Health and Welfare in 2012, malignant tumors are the leading cause of death in Taiwan for 32 consecutive years, and the top 5 cancers with the largest number of cancers and deaths are colorectal cancer, liver cancer, lung cancer, breast cancer, and oral cancer. (including oropharynx, hypopharynx). Taking oral cancer as an example, it is obviously related to the habit of Taiwanese chewing betel nuts and smoking. Oral cancer occurs in the cheek mucosa and lower gums of the betel nut chews. Patients often wait until the symptoms of pain, swelling or facial deformation have entered the advanced stage, and the five-year survival rate is reduced by more than half compared with the early cancer. Early diagnosis and appropriate treatment in the early stages of oral cancer can reduce mortality, so early screening for oral cancer is an important issue.
目前常見的癌症篩檢的方法有醫生目視或觸診、病理切片檢查等,其中較精確的診斷為病理切片檢查,但是,病理切片檢查屬於侵入式的檢查,造成病患傷口的產生,而且這個過程也會引起病患的心理負擔、恐懼與身體上的疼痛,其結果也必須經過癌症專科病理醫師的詳細判讀和分析才可以確定腫瘤是良性或惡性。At present, common methods for screening cancer include doctor's visual inspection or palpation, pathological biopsy, etc. The more accurate diagnosis is pathological biopsy. However, pathological biopsy is an invasive examination, resulting in the formation of wounds in patients, and this The process can also cause the patient's psychological burden, fear and physical pain, and the results must be carefully interpreted and analyzed by a cancer specialist pathologist to determine whether the tumor is benign or malignant.
另一種常用的是非侵入式癌症篩檢方法,相較於侵入式的病理切片檢查較不會造成病患的不適。市面上的非侵入式口腔癌篩檢包含有刷式組織檢查、苯胺藍(Toluidin Blue)特殊染色檢查,以及自體螢光影像檢查。其中,刷式組織檢查只能夠篩檢口腔上皮組織異常增生,而苯胺藍特殊染色檢查需花上至少5分鐘等待口腔組織染色。自體螢光影像檢查沒有前述兩種非侵入式口腔癌篩檢的缺陷,並且具有較大的篩檢區域,同時也具有即時顯示的優勢,因此,已成為醫界重要研究課題之一。Another commonly used non-invasive cancer screening method is less likely to cause discomfort to the patient than invasive pathological biopsy. Non-invasive oral cancer screening on the market includes brush tissue examination, Toluidin Blue special staining, and autofluorescence imaging. Among them, brush tissue examination can only screen abnormal growth of oral epithelial tissue, while aniline blue special staining examination takes at least 5 minutes to wait for oral tissue staining. Autofluorescence imaging has no defects in the above two non-invasive oral cancer screening, and has a large screening area, and also has the advantage of instant display. Therefore, it has become one of the important research topics in the medical field.
本創作的目的為提供一種檢測裝置,可利用自體螢光影像進行非侵入式癌症篩檢,藉此提供醫護人員診斷的依據。The purpose of this creation is to provide a detection device that can perform non-invasive cancer screening using autofluorescence images to provide a basis for medical personnel diagnosis.
本創作提供一種檢測裝置,其包含一影像擷取模組、一光源模組以及一濾光模組。影像擷取模組具有一鏡頭。光源模組鄰設於影像擷取模組。濾光模組具有一架體及一第一濾光片位於架體,且架體於至少一第一位置及一第二位置之間擺動。其中,當架體位於第一位置時,第一濾光片位於鏡頭之一影像擷取方向上,鏡頭經由第一濾光片擷取至少一第一影像,當架體位於第二位置時,鏡頭擷取至少一第二影像。The present invention provides a detecting device comprising an image capturing module, a light source module and a filter module. The image capture module has a lens. The light source module is adjacent to the image capturing module. The filter module has a frame and a first filter disposed on the frame, and the frame swings between the at least one first position and the second position. Wherein, when the frame is in the first position, the first filter is located in an image capturing direction of the lens, and the lens captures at least one first image through the first filter, when the frame is in the second position, The lens captures at least one second image.
在本創作一個實施例中,濾光模組更具有一開口位於架體上,且開口位於鏡頭之影像擷取方向上,鏡頭經由開口擷取第二影像。其中,當開口位於鏡頭之影像擷取方向上,鏡頭所擷取之第二影像為自然光影像。In an embodiment of the present invention, the filter module further has an opening on the frame, and the opening is located in the image capturing direction of the lens, and the lens captures the second image through the opening. Wherein, when the opening is located in the image capturing direction of the lens, the second image captured by the lens is a natural light image.
在本創作一個實施例中,至少部分濾光模組位於影像擷取模組與光源模組之間。另外,第一濾光片及開口是實質上位於同一擺動平面,且鏡頭之影像擷取方向是與擺動平面實質上垂直。此外,架體具有一支點,支點是位於濾光模組之重心之外側,且是藉由支點以帶動架體往復擺動。In an embodiment of the present invention, at least a portion of the filter module is located between the image capture module and the light source module. In addition, the first filter and the opening are substantially in the same swing plane, and the image capturing direction of the lens is substantially perpendicular to the swing plane. In addition, the frame body has a point, and the fulcrum is located outside the center of gravity of the filter module, and is driven by the fulcrum to drive the frame body to reciprocate.
在本創作一個實施例中,光源模組具有一第一光源與一第二光源,當鏡頭經由第一濾光片擷取第一影像時,第一光源為發光狀態;當鏡頭經由開口擷取第二影像時,第二光源為發光狀態。其中,第一光源包含至少一藍光發光二極體或至少一紫外光發光二極體,第二光源包含至少一白光發光二極體。In an embodiment of the present invention, the light source module has a first light source and a second light source. When the lens captures the first image through the first filter, the first light source is in a light-emitting state; when the lens is captured through the opening In the second image, the second light source is in a light-emitting state. The first light source includes at least one blue light emitting diode or at least one ultraviolet light emitting diode, and the second light source includes at least one white light emitting diode.
在本創作一個實施例中,濾光模組更具有一第二濾光片,第二濾光片位於架體。另外,架體更具有一第三位置,且架體是被帶動於第一位置、第二位置及第三位置之間擺動,因此,當架體位於第三位置時,第二濾光片位於鏡頭之影像擷取方向上,鏡頭經由第二濾光片擷取至少一第三影像。In an embodiment of the present invention, the filter module further has a second filter, and the second filter is located on the frame. In addition, the frame body further has a third position, and the frame body is driven to swing between the first position, the second position and the third position, so when the frame body is in the third position, the second filter is located In the image capturing direction of the lens, the lens captures at least one third image through the second filter.
在本創作一個實施例中,光源模組具有一第一光源、一第二光源及一第三光源,當鏡頭經由第一濾光片擷取第一影像時,第一光源為發光狀態;當鏡頭經由開口擷取第二影像時,第二光源為發光狀態,當鏡頭經由第二濾光片擷取第三影像時,第三光源為發光狀態。In an embodiment of the present invention, the light source module has a first light source, a second light source, and a third light source. When the lens captures the first image through the first filter, the first light source is in a light-emitting state; When the lens captures the second image through the opening, the second light source is in a light-emitting state, and when the lens captures the third image through the second filter, the third light source is in a light-emitting state.
在本創作一個實施例中,檢測裝置更具有一握柄G,鏡頭之影像擷取方向與握柄G夾角介於135度至 180度之間。In an embodiment of the present invention, the detecting device further has a grip G, and the image capturing direction of the lens is at an angle of between 135 and 180 degrees with the grip G.
在本創作一個實施例中,檢測裝置是為一手持式口腔檢測裝置,光源模組激發標的產生一螢光。In one embodiment of the present invention, the detecting device is a hand-held oral detecting device, and the light source module excites the target to generate a fluorescent light.
承上所述,於本創作的檢測裝置中,濾光模組的第一濾光片位於架體上,且架體可於至少第一位置及第二位置之間擺動。其中,當架體位於第一位置時,第一濾光片位於鏡頭之影像擷取方向上,鏡頭可經由第一濾光片擷取至少一第一影像;另外,當架體位於第二位置時,鏡頭可擷取沒有濾光片(即自然光)的至少一第二影像。因此,本創作的檢測裝置是利用自體螢光影像進行非侵入式癌症篩檢,藉由經第一濾光片與不經濾光片所分別取得的第一影像與第二影像,可讓醫護人員比對自然光的影像與經由濾光片所得到的影像,藉此提高臨床經驗的癌症篩檢與判斷的準確性。As described above, in the detecting device of the present invention, the first filter of the filter module is located on the frame, and the frame is swingable between at least the first position and the second position. Wherein, when the frame is in the first position, the first filter is located in the image capturing direction of the lens, and the lens can capture at least one first image through the first filter; and when the frame is in the second position At the time, the lens can capture at least one second image without a filter (ie, natural light). Therefore, the detection device of the present invention uses a self-fluorescent image for non-invasive cancer screening, and the first image and the second image respectively obtained by the first filter and the non-filter can be used. The medical staff compares the images of natural light with the images obtained through the filters, thereby improving the accuracy of clinical screening for cancer screening and judgment.
以下將參照相關圖式,說明依本創作較佳實施例的檢測裝置,其中相同的元件將以相同的元件符號加以說明。本創作所有實施態樣的圖示只是示意,不代表真實尺寸與比例。Hereinafter, a detecting apparatus according to a preferred embodiment of the present invention will be described with reference to the related drawings, in which the same elements will be described with the same reference numerals. The illustrations of all the implementations of this creation are merely illustrative and do not represent true dimensions and proportions.
人體本身就有許多光感應物質(Fluorochrome),受光照射會放出不同的螢光,此即為自體螢光特性。利用異常組織和周圍正常組織的自體螢光特性不同,可鑑別出異常組織的存在。本創作的檢測裝置就是利用自體螢光影像來進行非侵入式異常組織(癌症)篩檢,藉此提供醫護人員診斷的依據。The human body itself has many light-sensitive substances (Fluorochrome), which emit different fluorescent light when illuminated by light, which is the self-fluorescent property. The presence of abnormal tissue can be identified by using different autofluorescence characteristics of abnormal tissue and surrounding normal tissue. The creation of the detection device is to use non-invasive abnormal tissue (cancer) screening by using autofluorescence images, thereby providing a basis for medical personnel diagnosis.
請參照圖1與圖2所示,其分別為本創作較佳實施例之一種檢測裝置1的組合示意圖與分解示意圖。檢測裝置1包括一影像擷取模組11、一光源模組12、一濾光模組13。另外,本實施例的檢測裝置1更包括一第一殼體14、一第二殼體15、一控制電路板16與一致能開關17。Please refer to FIG. 1 and FIG. 2 , which are respectively a schematic diagram and a schematic exploded view of a detecting device 1 according to a preferred embodiment of the present invention. The detecting device 1 includes an image capturing module 11 , a light source module 12 , and a filter module 13 . In addition, the detecting device 1 of the embodiment further includes a first housing 14 , a second housing 15 , a control circuit board 16 and a uniform energy switch 17 .
檢測裝置1用以檢測一標的,例如為人體組織,例如但不限於為人體的口腔組織。本實施例的檢測裝置1為一手持式口腔檢測裝置,讓醫護人員可手持檢測裝置1以伸入患者的口腔,利用患者照光後的自體螢光影像來進行即時的非侵入式的口腔異常組織(癌症)篩檢。當然,在不同的實施例中,檢測裝置1也可為非手持式的非侵入式檢測裝置,且可檢測其他位置的組織,例如檢測皮膚是否發生癌病變等,本創作並不限制。The detecting device 1 is used for detecting a target, such as human tissue, such as, but not limited to, oral tissue of a human body. The detecting device 1 of the embodiment is a hand-held oral detecting device, which allows the medical staff to carry the detecting device 1 into the patient's mouth and use the self-fluorescent image of the patient to perform an immediate non-invasive oral abnormality. Tissue (cancer) screening. Of course, in different embodiments, the detecting device 1 can also be a non-handheld non-invasive detecting device, and can detect tissues at other locations, for example, detecting whether a skin has a cancerous lesion or the like, and the creation is not limited.
第一殼體14與第二殼體15相互組合以構成一容置空間,例如但不限於以卡合或鎖合進行組合,或以其他合適的組合方式。其中,容置空間內設有多個卡合座或鎖合座,藉此容置與固定影像擷取模組11、光源模組12、濾光模組13、控制電路板16與致能開關17等元件。影像擷取模組11、光源模組12與致能開關17分別與控制電路板16電性連接,以受控於控制電路板16上設置的一處理器161、電路與元件。處理器161可為檢測裝置1之核心控制器,例如可包含至少一中央處理器(CPU)。另外,控制電路板16上也可以設置記憶模組或傳輸介面等。記憶模組例如為記憶體或安全數位卡(secure digital memory card)。而傳輸介面可例如但不限於為通用串行匯流排(Universal Serial Bus,USB)。此外,第一殼體14與第二殼體15組合後可形成一握柄G,以供醫護人員握持。The first housing 14 and the second housing 15 are combined with each other to form an accommodation space, such as but not limited to being combined by snapping or locking, or in other suitable combinations. Wherein, a plurality of engaging seats or locking seats are disposed in the accommodating space, thereby accommodating and fixing the image capturing module 11, the light source module 12, the filter module 13, the control circuit board 16 and the enabling switch 17 and other components. The image capturing module 11 , the light source module 12 and the enabling switch 17 are electrically connected to the control circuit board 16 respectively to be controlled by a processor 161 , a circuit and a component disposed on the control circuit board 16 . The processor 161 can be a core controller of the detection device 1, for example, can include at least one central processing unit (CPU). In addition, a memory module or a transmission interface or the like may be disposed on the control circuit board 16. The memory module is, for example, a memory or a secure digital memory card. The transmission interface can be, for example but not limited to, a Universal Serial Bus (USB). In addition, the first housing 14 and the second housing 15 can be combined to form a grip G for the medical staff to hold.
請參照圖2並配合圖3A至圖3C,以詳細說明影像擷取模組11、光源模組12、濾光模組13的詳細技術內容。其中,圖3A至圖3C分別為圖2之檢測裝置1中,影像擷取模組11、光源模組12與濾光模組13的相對示意圖。Referring to FIG. 2 and FIG. 3A to FIG. 3C , detailed technical contents of the image capturing module 11 , the light source module 12 , and the filter module 13 are described in detail. 3A to 3C are respectively relative schematic views of the image capturing module 11, the light source module 12 and the filter module 13 in the detecting device 1 of FIG.
影像擷取模組11具有一鏡頭111,例如為感光耦合元件(Charge-coupled Device,CCD)、互補式金屬氧化物半導體(Complementary Metal-Oxide-Semiconductor,CMOS)或其他適合的感光元件。在一些實施例中,影像擷取模組11也可以包括光圈、快門等元件。The image capturing module 11 has a lens 111, such as a Charge-coupled Device (CCD), a Complementary Metal-Oxide-Semiconductor (CMOS) or other suitable photosensitive element. In some embodiments, the image capturing module 11 may also include components such as an aperture, a shutter, and the like.
光源模組12鄰設於影像擷取模組11,並可發出光線以激發標的產生一螢光。其中,光源模組12可提供白光光源(自然光)、UV波長(波長例如為375nm)、藍光波長(波長例如為460nm),或其他波長的光源。在本實施例中,光源模組12包含多個發光二極體(light emitting diode,LED)121,並包含至少一白光發光二極體、至少一藍光發光二極體與至少一紫外光發光二極體,以分別發出白光、UV光或藍光。在其他實施例中,光源模組12也可包含其他適合的光源。另外,除了發光二極體121之外,光源模組12更具有一基板122,該些發光二極體121設置於基板122上,而且基板122上具有一個通孔123。The light source module 12 is adjacent to the image capturing module 11 and emits light to excite the target to generate a fluorescent light. The light source module 12 can provide a white light source (natural light), a UV wavelength (wavelength of, for example, 375 nm), a blue light wavelength (wavelength of, for example, 460 nm), or a light source of other wavelengths. In this embodiment, the light source module 12 includes a plurality of light emitting diodes (LEDs) 121 and includes at least one white light emitting diode, at least one blue light emitting diode, and at least one ultraviolet light emitting light. Polar body to emit white light, UV light or blue light, respectively. In other embodiments, the light source module 12 can also include other suitable light sources. In addition, in addition to the LEDs 121, the light source module 12 further has a substrate 122. The LEDs 121 are disposed on the substrate 122, and the substrate 122 has a through hole 123 therein.
濾光模組13具有一架體131、一第一濾光片132及一開口O,第一濾光片132與開口O是位於架體131上,且架體131可於至少一第一位置P1及一第二位置P2之間擺動。如圖3A所示,當架體131擺動而位於第一位置P1時,第一濾光片132位於鏡頭111之一影像擷取方向D上(影像擷取方向D與醫護人員看的方向大致相同),且鏡頭111可經由第一濾光片132擷取至少一第一影像;另外,如圖3B所示,當架體131擺動而位於第二位置P2時,開口O則位於鏡頭111之影像擷取方向D上,且鏡頭111可經由開口O擷取至少一第二影像。The filter module 13 has a frame 131, a first filter 132 and an opening O. The first filter 132 and the opening O are located on the frame 131, and the frame 131 can be at least a first position. Swing between P1 and a second position P2. As shown in FIG. 3A, when the frame 131 is swung and located at the first position P1, the first filter 132 is located in the image capturing direction D of the lens 111 (the image capturing direction D is substantially the same as the direction viewed by the medical staff). And the lens 111 can capture at least one first image through the first filter 132; in addition, as shown in FIG. 3B, when the frame 131 is swung to be in the second position P2, the opening O is located in the image of the lens 111. The direction D is captured, and the lens 111 can capture at least one second image through the opening O.
架體131上除了第一濾光片132與開口O之外,本實施例之濾光模組13更具有一第二濾光片133,第二濾光片133亦位於架體131上。如圖3C所示,架體131擺動時更具有一第三位置P3,且架體131可被帶動於第一位置P1、第二位置P2及第三位置P3之間擺動。其中,當架體131擺動而位於第三位置P3時,第二濾光片133則位於鏡頭111之影像擷取方向D上,且鏡頭111可經由第二濾光片133擷取至少一第三影像。於此,開口O分別鄰接於第一濾光片132與第二濾光片133,且第一濾光片132、開口O與第二濾光片133實質上位於同一擺動平面,而且鏡頭111之影像擷取方向D是與該擺動平面實質上垂直。In addition to the first filter 132 and the opening O, the filter module 13 of the present embodiment further has a second filter 133, and the second filter 133 is also located on the frame 131. As shown in FIG. 3C, the frame body 131 has a third position P3 when it is swung, and the frame body 131 can be swung between the first position P1, the second position P2 and the third position P3. When the frame 131 is swung and located at the third position P3, the second filter 133 is located in the image capturing direction D of the lens 111, and the lens 111 can capture at least one third through the second filter 133. image. The openings O are adjacent to the first filter 132 and the second filter 133, respectively, and the first filter 132, the opening O and the second filter 133 are substantially in the same swing plane, and the lens 111 is The image capturing direction D is substantially perpendicular to the oscillating plane.
在本實施例中,架體131上的第一濾光片132、開口O及第二濾光片133之排列並非位於同一直線上(三者的幾何中心點並不在一直線上),且架體131上的第一濾光片132、開口O及第二濾光片133實質上是位於同一平面上(該平面為架體131本身形成的平面)。另外,開口O是位於第一濾光片132及第二濾光片133之間。不過,在不同的實施例中,也可第一濾光片132位於開口O與第二濾光片133之間,或第二濾光片133位於開口O與第一濾光片132之間,本創作均不限制。In this embodiment, the arrangement of the first filter 132, the opening O, and the second filter 133 on the frame 131 is not on the same straight line (the geometric center points of the three are not in a straight line), and the frame body The first filter 132, the opening O, and the second filter 133 on the 131 are substantially on the same plane (the plane is a plane formed by the frame body 131 itself). Further, the opening O is located between the first filter 132 and the second filter 133. However, in different embodiments, the first filter 132 may be located between the opening O and the second filter 133, or the second filter 133 may be located between the opening O and the first filter 132. This creation is not limited.
另外,本實施例的架體131上的開口O大致呈三角形或扇形,而第一濾光片132與第二濾光片133大致呈矩形,然並不以此為限,在不同的實施例中,開口O亦可為梯形或其他形狀,且第一濾光片132與第二濾光片133亦可為其他形狀,例如梯形、圓形或其他形狀。在不同的實施例中,如圖4A所示,架體131a上的開口O為開放的V字形狀而不具有邊框。In addition, the opening O of the frame 131 of the present embodiment is substantially triangular or fan-shaped, and the first filter 132 and the second filter 133 are substantially rectangular, but not limited thereto, in different embodiments. The opening O may also be trapezoidal or other shape, and the first filter 132 and the second filter 133 may have other shapes, such as trapezoidal, circular or other shapes. In various embodiments, as shown in FIG. 4A, the opening O on the frame body 131a is an open V-shape without a bezel.
另外,請再參照圖3A所示,本實施例之濾光模組13更具有一馬達134、二齒輪135、136與一轉軸137。馬達134例如但不限於為步進馬達或伺服馬達,並與控制電路板16之處理器161電性連接,以接受處理器161的控制。齒輪135安裝於馬達134之轉軸上,並與齒輪136咬合。轉軸137的二端分別連接於齒輪136與架體131的一支點1311上。由於本實施例的架體131也大致呈扇形,故架體131的支點1311是位於濾光模組13之重心的外側,故轉軸137可藉由支點1311帶動架體131左右往復擺動。其中,可以控制方式將架體131限制於第一位置P1與第三位置P3之間擺動,或者也可透過例如限動開關(圖未示)將架體131限制在第一位置P1與第三位置P3之間擺動(上述的限動開關亦可作為調校位置之用)。另外,由於架體131的形狀設計上大致呈扇形,因此也可減少檢測裝置1的體積,方便醫護人員使用與伸入患者的口腔內。In addition, as shown in FIG. 3A , the filter module 13 of the embodiment further has a motor 134 , two gears 135 , 136 and a rotating shaft 137 . The motor 134 is, for example but not limited to, a stepper motor or a servo motor, and is electrically coupled to the processor 161 of the control circuit board 16 to be controlled by the processor 161. The gear 135 is mounted on the rotating shaft of the motor 134 and meshes with the gear 136. The two ends of the rotating shaft 137 are respectively connected to the gear 136 and a point 1311 of the frame body 131. Since the frame body 131 of the present embodiment is also substantially fan-shaped, the fulcrum 1311 of the frame body 131 is located outside the center of gravity of the filter module 13, so that the rotating shaft 137 can drive the frame body 131 to swing back and forth by the fulcrum 1311. The frame 131 can be controlled to be swayed between the first position P1 and the third position P3, or the frame 131 can be restricted to the first position P1 and the third by, for example, a limit switch (not shown). Swing between positions P3 (the above-mentioned limit switch can also be used as the adjustment position). In addition, since the shape of the frame body 131 is substantially fan-shaped, the volume of the detecting device 1 can also be reduced, which is convenient for the medical staff to use and extend into the oral cavity of the patient.
請再參照圖2所示,致能開關17設置於控制電路板16上並穿過第一殼體14而突出於外界,且致能開關17與控制電路板16上的處理器161與電路電性連接。在一些實施例中,可按下致能開關17後,處理器161同時控制馬達134轉動而連動架體131,並控制光源模組12的對應光源發光,且使影像擷取模組11的鏡頭111取得影像,處理器161取得該影像後進行影像處理、計算;或者,在不同的實施例中,可按下致能開關17後,處理器161控制馬達134轉動並連動架體131,當架體131擺動而觸發例如限動開關時,再控制光源模組12對應的光源發光,同時使影像擷取模組11的鏡頭111取得影像,處理器161取得該影像後進行影像處理、計算,本創作均不限制。上述鏡頭111所擷取的影像可以先儲存在控制電路板16上的記憶體中,接著透過控制電路板16上的傳輸介面傳送到另一個電子裝置(例如為電腦),而此電子裝置可以顯示這些擷取到的影像,以供醫護人員檢查口腔內是否有異常組織。Referring to FIG. 2 again, the enable switch 17 is disposed on the control circuit board 16 and protrudes through the first housing 14 to the outside, and activates the switch 17 and the processor 161 and the circuit on the control circuit board 16. Sexual connection. In some embodiments, after the enable switch 17 is pressed, the processor 161 simultaneously controls the rotation of the motor 134 to link the frame 131, and controls the corresponding light source of the light source module 12 to emit light, and the lens of the image capturing module 11 is made. 111, the image is acquired, the processor 161 obtains the image, and then performs image processing and calculation; or, in different embodiments, after the enable switch 17 is pressed, the processor 161 controls the motor 134 to rotate and interlock the frame 131. When the body 131 is swung to trigger, for example, a limit switch, the light source corresponding to the light source module 12 is controlled to emit light, and the lens 111 of the image capturing module 11 is used to acquire an image. The processor 161 obtains the image and performs image processing and calculation. There is no limit to the creation. The image captured by the lens 111 can be first stored in the memory on the control circuit board 16, and then transmitted to another electronic device (for example, a computer) through the transmission interface on the control circuit board 16, and the electronic device can display These captured images are for medical personnel to check for abnormal tissue in the mouth.
另外,至少部分濾光模組13是位於影像擷取模組11與光源模組12之間。例如圖3A中,濾光模組13之架體131上的第一濾光片132是位於影像擷取模組11之鏡頭111與光源模組12之間。另外,本實施例的影像擷取模組11之鏡頭111是位於馬達134與架體131之間,而架體131位於鏡頭111與光源模組12之間,且鏡頭111之影像擷取方向D可通過架體131之開口O、或第一濾光片132、或第二濾光片133,及光源模組12的通孔123與第一殼體14與第二殼體15所形成,且位於裝置前端的一缺口H。因此,當光源模組12之發光二極體121發出的光線照射到標的時,標的所放出的螢光或反射光線可由缺口H、通孔123、架體131上之開口O、或第一濾光片132、或第二濾光片133而被鏡頭111所接收,經控制電路板16之處理器161處理後,可產生一影像。在此實施例中,醫護人員可以握住握柄G,以將檢測裝置1前端(缺口H)伸入患者的口中。其中,為了使醫護人員握持檢測裝置1時的手感較好,容易操作,鏡頭111之影像擷取方向D與握柄G之間的夾角較佳者是介於135度至 180度之間。In addition, at least a part of the filter module 13 is located between the image capturing module 11 and the light source module 12 . For example, in FIG. 3A , the first filter 132 on the frame 131 of the filter module 13 is located between the lens 111 of the image capturing module 11 and the light source module 12 . In addition, the lens 111 of the image capturing module 11 of the embodiment is located between the motor 134 and the frame 131, and the frame 131 is located between the lens 111 and the light source module 12, and the image capturing direction D of the lens 111 The first housing 14 and the second housing 15 can be formed by the opening O of the frame 131, or the first filter 132 or the second filter 133, and the through hole 123 of the light source module 12, and A notch H at the front end of the device. Therefore, when the light emitted by the light-emitting diode 121 of the light source module 12 is irradiated to the target, the fluorescent or reflected light emitted by the target may be the notch H, the through hole 123, the opening O on the frame 131, or the first filter. The light sheet 132 or the second color filter 133 is received by the lens 111, and processed by the processor 161 of the control circuit board 16 to generate an image. In this embodiment, the medical staff can hold the grip G to extend the front end (notch H) of the detecting device 1 into the mouth of the patient. In order to make the medical staff feel good and easy to operate when holding the detecting device 1, the angle between the image capturing direction D of the lens 111 and the grip G is preferably between 135 and 180 degrees.
一般來說,當口腔中有腫瘤時,腫瘤周邊血管會增生,造成附近的組織缺氧及充血。由於血液對於自體螢光的吸收係數在波長為約200奈米(nm)至約600nm範圍時較高,故在這波段激發出的自體螢光會被血液吸收,造成腫瘤附近螢光較暗。另外,有研究指出,在生物體內缺氧或發生腫瘤的情況,細胞內菸鹼醯胺腺嘌呤雙核苷酸(NADH)的濃度會上升且黃素腺嘌呤二核苷酸(FAD)的濃度會下降,在此實施例中便是以不同波長的光源來分別激發NADH與FAD。以下將舉例來說明如何拍攝不同波長的螢光影像。In general, when there is a tumor in the mouth, the blood vessels around the tumor will proliferate, causing hypoxia and congestion in nearby tissues. Since the absorption coefficient of blood for autofluorescence is higher at a wavelength ranging from about 200 nanometers (nm) to about 600 nm, autofluorescence excited in this band is absorbed by blood, resulting in fluorescence near the tumor. dark. In addition, studies have shown that in the absence of oxygen or tumors in the body, the concentration of nicotine indoleamine adenine dinucleotide (NADH) will increase and the concentration of flavin adenine dinucleotide (FAD) will Falling, in this embodiment, the light sources of different wavelengths are used to excite NADH and FAD, respectively. The following is an example of how to take fluorescent images of different wavelengths.
在本實施例中,當致能開關17被按下而使馬達134轉動時,齒輪135、136亦會轉動而帶動轉軸137轉動,使架體131於第一位置P1、第二位置P2與第三位置P2之間擺動,以使架體131上的第一濾光片131(綠色,對應於第一位置P1)、或開口O(對應於第二位置P2)、或第二濾光片133(藍色,對應於第三位置P3)位於鏡頭111之影像擷取方向D上。其中,第一濾光片132的作動是對應至藍光光源(於此稱為光源模組12的第一光源,包含至少一藍光發光二極體)所激發出來之螢光,而開口O是對應至白光光源(於此稱為光源模組12的第二光源,包含至少一白光發光二極體)所反射之白光,且第二濾光片133的作動是對應至UV光源(於此稱為光源模組12的第三光源,包含至少一紫外光發光二極體)所激發出來之螢光。In this embodiment, when the enable switch 17 is pressed to rotate the motor 134, the gears 135, 136 also rotate to drive the rotating shaft 137 to rotate, so that the frame 131 is in the first position P1, the second position P2 and the first The three positions P2 are swung to make the first filter 131 (green, corresponding to the first position P1), or the opening O (corresponding to the second position P2), or the second filter 133 on the frame 131. (blue, corresponding to the third position P3) is located in the image capturing direction D of the lens 111. The operation of the first filter 132 corresponds to the fluorescence excited by the blue light source (referred to as the first light source of the light source module 12, including at least one blue light emitting diode), and the opening O corresponds to The white light reflected by the white light source (referred to herein as the second light source of the light source module 12, including at least one white light emitting diode), and the second filter 133 is operated corresponding to the UV light source (herein referred to as The third light source of the light source module 12 includes the fluorescent light excited by the at least one ultraviolet light emitting diode.
具體來說,本實施例的光源模組12中提供藍光光源的LED 121是對應至第一濾光片132(綠色),提供白光光源的LED是對應至開口O,而UV光源的LED 121是對應至第二濾光片133(藍色)。不過,在不同的實施例中,光源模組12中提供藍光光源的LED 121可對應至第二濾光片133(綠色),且光源模組12中提供UV光源的LED 121可對應至第一濾光片132(藍色),本創作並不限定。另外,由於架體131是設置在光源模組12與鏡頭111之間,因此從缺口H與通孔123 進來的光線會經過第一濾光片132、或開口O、或第二濾光片133而被影像擷取模組11所接收。另外,透過齒輪135、136帶動轉軸137可以選擇第一濾光片132、開口O與第二濾光片133的其中一個位於通孔123與影像擷取模組11的鏡頭111之間。Specifically, the LED 121 that provides the blue light source in the light source module 12 of the embodiment corresponds to the first filter 132 (green), the LED that provides the white light source corresponds to the opening O, and the LED 121 of the UV light source is Corresponding to the second filter 133 (blue). However, in different embodiments, the LED 121 providing the blue light source in the light source module 12 may correspond to the second filter 133 (green), and the LED 121 providing the UV light source in the light source module 12 may correspond to the first Filter 132 (blue), this creation is not limited. In addition, since the frame 131 is disposed between the light source module 12 and the lens 111, light entering from the notch H and the through hole 123 passes through the first filter 132, or the opening O, or the second filter 133. It is received by the image capturing module 11. In addition, the first filter 132, one of the opening O and the second filter 133 are disposed between the through hole 123 and the lens 111 of the image capturing module 11 through the gears 135 and 136.
此外,特別一提的是,在不同的實施態樣中,架體131亦可以支點1311為中心而轉動,使第一濾光片132、開口O與第二濾光133轉動到支點1311的下側。如圖4B所示,其為本發明不同實施態樣的檢測裝置中,影像擷取模組11、光源模組12與濾光模組13的相對示意圖。In addition, in different embodiments, the frame body 131 can also rotate around the fulcrum 1311 to rotate the first filter 132, the opening O and the second filter 133 to the fulcrum 1311. side. As shown in FIG. 4B , it is a schematic diagram of the image capturing module 11 , the light source module 12 and the filter module 13 in the detecting device of different embodiments of the present invention.
在此實施態樣中,由於架體131以支點1311為中心轉動而完全轉開,故架體131已不位於鏡頭111之影像擷取方向D上,而且可將此位置視為上述的第二位置P2,並同樣以鏡頭111擷取此位置(仍稱第二位置P2)的影像,此影像可視為上述的第二影像。因此,於此實施態樣中,鏡頭111擷取第二影像時,沒有經由架體131上的第一濾光片132、第二濾光片133,也不經由架體131上的開口O,但是同樣可擷取到自然光的第二影像。In this embodiment, since the frame 131 is rotated completely around the fulcrum 1311, the frame 131 is not located in the image capturing direction D of the lens 111, and the position can be regarded as the second At position P2, the image of this position (still referred to as the second position P2) is also captured by the lens 111, and the image can be regarded as the second image described above. Therefore, in this embodiment, when the second image is captured by the lens 111, the first filter 132 and the second filter 133 on the frame 131 are not passed, and the opening O on the frame 131 is not used. But a second image of natural light can also be captured.
承上,當致能開關17被致能時,如圖3A所示,處理器161會驅動馬達134帶動架體131擺動至第一位置P1,使第一濾光片132位於通孔123 與影像擷取模組11之間,並驅動光源模組12的至少一發光二極體121(第一光源)提供藍光波長的光源(此時第二光源與第三光源不發光)照射在標的組織,處理器161同時控制影像擷取模組11的鏡頭111經由第一濾光片132擷取由標的所發出的第一影像。接下來,如圖3B所示,處理器161會驅動馬達134帶動架體131擺動至第二位置P2,使開口O位於通孔123 與影像擷取模組11之間,並驅動光源模組12的至少一發光二極體121(第二光源)提供白光波長的光源(此時第一光源與第三光源不發光)照射在標的組織,處理器161同時控制影像擷取模組11的鏡頭111經由開口O擷取標的反射的第二影像。之後,如圖3C所示,處理器161還會再次驅動馬達134帶動架體131擺動至第三位置P3,使第二濾光片133位於通孔123 與影像擷取模組11之間,並驅動光源模組12的至少一發光二極體121(第三光源)提供UV光波長的光源(此時第一光源與第二光源不發光)照射在標的組織,處理器161同時控制影像擷取模組11的鏡頭111經由第二濾光片133擷取由標的發出的第三影像。When the enable switch 17 is enabled, as shown in FIG. 3A, the processor 161 drives the motor 134 to swing the frame 131 to the first position P1, so that the first filter 132 is located in the through hole 123 and the image. The light source between the modules 11 and the at least one light-emitting diode 121 (first light source) of the light source module 12 is provided to provide a blue light source (where the second light source and the third light source do not emit light) to illuminate the target tissue. The processor 161 simultaneously controls the lens 111 of the image capturing module 11 to capture the first image emitted by the target via the first filter 132. Next, as shown in FIG. 3B, the processor 161 drives the motor 134 to swing the frame 131 to the second position P2, so that the opening O is located between the through hole 123 and the image capturing module 11, and drives the light source module 12 The at least one light emitting diode 121 (second light source) provides a light source of white light wavelength (when the first light source and the third light source do not emit light), and the processor 161 simultaneously controls the lens 111 of the image capturing module 11 The second reflected image of the target is captured via the opening O. Then, as shown in FIG. 3C, the processor 161 further drives the motor 134 to swing the frame 131 to the third position P3, so that the second filter 133 is located between the through hole 123 and the image capturing module 11, and At least one light emitting diode 121 (third light source) driving the light source module 12 supplies a light source of a UV light wavelength (in which case the first light source and the second light source do not emit light), and the processor 161 simultaneously controls image capturing. The lens 111 of the module 11 captures the third image emitted by the target via the second filter 133.
因此,在本實施例中,當致能開關17被按下時,檢測裝置1便會自動地取得三張影像。然而,上述取得影像的順序僅是一範例,本創作並不限制取得影像的順序。或者,使用者也可以透過一些額外設置的按鈕、開關等人機介面來選擇要擷取那些波長的影像。上述的第一影像可以用來表示FAD的濃度,第三影像可用來表示NADH的濃度,而第二影像則是白光照射標的組織所反射的影像。因此,第二影像可提供給醫護人員與經由濾光片而得到的第一影像與第三影像進行比對,增加判斷的準確性。Therefore, in the present embodiment, when the enable switch 17 is pressed, the detecting device 1 automatically acquires three images. However, the order in which the images are acquired is only an example, and the creation does not limit the order in which images are obtained. Alternatively, the user can also select images to capture those wavelengths through a number of additional buttons, switches, and the like. The first image described above can be used to indicate the concentration of the FAD, the third image can be used to indicate the concentration of the NADH, and the second image is the image reflected by the tissue illuminated by the white light. Therefore, the second image can be provided to the medical staff to compare the first image and the third image obtained through the filter, thereby increasing the accuracy of the judgment.
另外,在此假設第一影像中某一像素的第一灰階值是配對至第三影像中某一像素的第二灰階值。在一些實施例中,處理器161也可將第一灰階值除以第一灰階值與第二灰階值的和以取得一比值,此比值便可用來判斷是否存在腫瘤。換言之,若把上述的第一灰階值標記為FAD,並把第二灰階值標記為NADH,則所計算出的比值可寫成以下方程式(1): FAD/(FAD+NADH) …(1)。In addition, it is assumed here that the first grayscale value of a certain pixel in the first image is a second grayscale value paired to a certain pixel in the third image. In some embodiments, the processor 161 may also divide the first grayscale value by the sum of the first grayscale value and the second grayscale value to obtain a ratio, which may be used to determine whether a tumor is present. In other words, if the first gray scale value is marked as FAD and the second gray scale value is marked as NADH, the calculated ratio can be written as the following equation (1): FAD / (FAD + NADH) ... (1 ).
在其他的實施例中,上述的比值也可以結合其他的特徵而成為一個特徵向量。例如,可以將口腔影像的異質性(heterogeneity)當作特徵向量中的一個元素(element),此異質性可為像素灰階值的變異數、熵值等,本創作並不在此限。另外,在一些實施例中,可事先收集許多口腔的樣本影像,對於每個樣本影像都擷取上述的特徵向量,這些特徵向量可經過一個機器學習演算法而得到一個訓練模型,接下來在測試時,處理器161便可以從目前的影像中擷取相同的特徵向量,便根據此特徵向量與上述的訓練模型來判斷是否有腫瘤。本創作並不限制用什麼學習演算法。此外,在一些實施例中,處理器161在判斷是否有腫瘤時也可以根據所使用的機器學習演算法來產生信心值(confidence value),藉此讓使用者知道有/無腫瘤的信心有多少。In other embodiments, the above ratio may be combined with other features to become a feature vector. For example, the heterogeneity of the oral image can be regarded as an element in the feature vector, and the heterogeneity can be the variation of the grayscale value of the pixel, the entropy value, etc., and the creation is not limited thereto. In addition, in some embodiments, a plurality of sample images of the oral cavity may be collected in advance, and the feature vectors are captured for each sample image, and the feature vectors may be subjected to a machine learning algorithm to obtain a training model, and then tested. The processor 161 can extract the same feature vector from the current image, and determine whether there is a tumor based on the feature vector and the training model. This creation does not limit what learning algorithms are used. Moreover, in some embodiments, the processor 161 can also generate a confidence value based on the machine learning algorithm used in determining whether there is a tumor, thereby allowing the user to know how much confidence there is/without a tumor. .
綜上所述,於本創作的檢測裝置中,濾光模組的第一濾光片位於架體上,且架體可於至少第一位置及第二位置之間擺動。其中,當架體位於第一位置時,第一濾光片位於鏡頭之影像擷取方向上,鏡頭可經由第一濾光片擷取至少一第一影像;另外,當架體位於第二位置時,鏡頭可擷取沒有濾光片(即自然光)的至少一第二影像。因此,本創作的檢測裝置是利用自體螢光影像進行非侵入式癌症篩檢,藉由經第一濾光片與不經濾光片所分別取得的第一影像與第二影像,可讓醫護人員比對自然光的影像與經由濾光片所得到的影像,藉此提高臨床經驗的癌症篩檢與判斷的準確性。In summary, in the detecting device of the present invention, the first filter of the filter module is located on the frame body, and the frame body can swing between at least the first position and the second position. Wherein, when the frame is in the first position, the first filter is located in the image capturing direction of the lens, and the lens can capture at least one first image through the first filter; and when the frame is in the second position At the time, the lens can capture at least one second image without a filter (ie, natural light). Therefore, the detection device of the present invention uses a self-fluorescent image for non-invasive cancer screening, and the first image and the second image respectively obtained by the first filter and the non-filter can be used. The medical staff compares the images of natural light with the images obtained through the filters, thereby improving the accuracy of clinical screening for cancer screening and judgment.
以上所述僅為舉例性,而非為限制性者。任何未脫離本創作之精神與範疇,而對其進行之等效修改或變更,均應包含於後附之申請專利範圍中。The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of this creation shall be included in the scope of the appended patent application.
1‧‧‧檢測裝置
11‧‧‧影像擷取模組
111‧‧‧鏡頭
12‧‧‧光源模組
121‧‧‧發光二極體
122‧‧‧基板
123‧‧‧通孔
13‧‧‧濾光模組
131、131a‧‧‧架體
1311‧‧‧支點
132‧‧‧第一濾光片
133‧‧‧第二濾光片
134‧‧‧馬達
135、136‧‧‧齒輪
137‧‧‧轉軸
14‧‧‧第一殼體
15‧‧‧第二殼體
16‧‧‧控制電路板
161‧‧‧處理器
17‧‧‧致能開關
D‧‧‧影像擷取方向
G‧‧‧握柄
H‧‧‧缺口
O‧‧‧開口
P1‧‧‧第一位置
P2‧‧‧第二位置
P3‧‧‧第三位置1‧‧‧Detection device
11‧‧‧Image capture module
111‧‧‧ lens
12‧‧‧Light source module
121‧‧‧Lighting diode
122‧‧‧Substrate
123‧‧‧through hole
13‧‧‧Filter module
131, 131a‧‧‧ frame
1311‧‧‧ pivot
132‧‧‧First filter
133‧‧‧Second filter
134‧‧‧ motor
135, 136‧‧‧ gears
137‧‧‧ shaft
14‧‧‧First housing
15‧‧‧ second housing
16‧‧‧Control circuit board
161‧‧‧ processor
17‧‧‧Enable switch
D‧‧‧Image capture direction
G‧‧‧ grip
H‧‧‧ gap
O‧‧‧ openings
P1‧‧‧ first position
P2‧‧‧ second position
P3‧‧‧ third position
圖1與圖2分別為本創作較佳實施例之一種檢測裝置的組合示意圖與分解示意圖。 圖3A至圖3C分別為圖2之檢測裝置中,影像擷取模組、光源模組與濾光模組的相對示意圖。 圖4A為架體的另一示意圖。 圖4B為本發明不同實施態樣的檢測裝置中,影像擷取模組、光源模組與濾光模組的相對示意圖。FIG. 1 and FIG. 2 are respectively a schematic diagram and a schematic exploded view of a detecting apparatus according to a preferred embodiment of the present invention. 3A to 3C are respectively relative schematic views of the image capturing module, the light source module and the filter module in the detecting device of FIG. 2 . Figure 4A is another schematic view of the frame. 4B is a schematic diagram of the image capturing module, the light source module and the filter module in the detecting device according to different embodiments of the present invention.
11‧‧‧影像擷取模組 11‧‧‧Image capture module
111‧‧‧鏡頭 111‧‧‧ lens
12‧‧‧光源模組 12‧‧‧Light source module
121‧‧‧發光二極體 121‧‧‧Lighting diode
122‧‧‧基板 122‧‧‧Substrate
123‧‧‧通孔 123‧‧‧through hole
13‧‧‧濾光模組 13‧‧‧Filter module
131‧‧‧架體 131‧‧‧ ‧ body
1311‧‧‧支點 1311‧‧‧ pivot
132‧‧‧第一濾光片 132‧‧‧First filter
133‧‧‧第二濾光片 133‧‧‧Second filter
134‧‧‧馬達 134‧‧‧ motor
135、136‧‧‧齒輪 135, 136‧‧‧ gears
137‧‧‧轉軸 137‧‧‧ shaft
D‧‧‧影像擷取方向 D‧‧‧Image capture direction
O‧‧‧開口 O‧‧‧ openings
P1‧‧‧第一位置 P1‧‧‧ first position
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI631532B (en) * | 2017-08-16 | 2018-08-01 | 台達電子工業股份有限公司 | Examination system and method thereof |
US10769781B2 (en) | 2017-04-24 | 2020-09-08 | Taihao Medical Inc. | System and method for cloud medical image analysis using self-learning model |
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US10769781B2 (en) | 2017-04-24 | 2020-09-08 | Taihao Medical Inc. | System and method for cloud medical image analysis using self-learning model |
TWI631532B (en) * | 2017-08-16 | 2018-08-01 | 台達電子工業股份有限公司 | Examination system and method thereof |
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