TWM526870U - Multi-light source microscopic positioning amplification capillary image capturing device for non-invasive glucometer - Google Patents

Description

Multi-source micro-positioning micro-vascular image capturing device for non-invasive blood glucose meter

This creation is related to a multi-source micro-positioning magnifying micro-vessel image capturing device for non-invasive blood glucose meters. The most advanced non-invasive blood glucose measuring method is to irradiate micro-vessels with infrared laser light and obtain micro-amplified infrared ray. The image of the light absorbed by the microvessels separates the microvessels from the image of the living tissue by magnifying the image, because the sugar in the blood is mainly referred to as glucose, which is referred to as glucose, and its molecular formula contains a plurality of hydroxyl groups (OH) and methyl groups (CH). All of them are main hydrogen-containing functional groups capable of generating absorption in the infrared spectral region, so the above-mentioned microvascular images are converted by Fourier transform, thereby becoming an infrared light imaging spectrum, and the absorption amount can be calculated by using the spectrum to measure glucose and thereby measuring blood sugar; Non-invasive blood glucose measurement method is a visible light laser that irradiates microvessels to detect Raman scattering caused by blood. This phenomenon occurs because the medium molecules themselves vibrate or rotate, causing incident photons and medium molecules to occur. Energy exchange, so that the frequency of the scattered light after reflection changes, so it can be utilized Mann's spectrum measures glucose and then measures blood sugar. When the sugar concentration changes, the change of diffuse reflected light energy is actually the result of the absorption effect and scattering effect caused by the change of sugar concentration, which affects the light propagation behavior. In different spatial positions, The effects of absorption and scattering effects on light intensity may reinforce each other and may cancel each other out. Often the results are still unsatisfactory due to the above factors. Reflecting with multi-source laser light, the user can obtain the microscopic enlarged image of the eardrum membrane with the LED flood light, and confirm that the image is a blood vessel gathering area, and then multi-light source is emitted to the eardrum through the light guiding optical fiber by the multi-light projector. Laser light, microscopically magnified microvascular image signal is taken through a conjugate focal length microscope, and the image signal is sent to the remote mobile device to perform infrared imaging spectrum and Raman imaging spectral conversion processing using infrared computing spectrum, using infrared spectrum And Raman spectroscopy, the spatial resolution and sensitivity of the analysis, can quickly measure the glucose content, which can be used to estimate the individual's blood sugar level; the above two methods of spectrometry are good, but to accurately measure blood sugar, but The difficulty is that infrared laser light can enter the internal tissue through the skin, but it can not distinguish the blood vessels and the living tissue. In contrast, the visible light laser can see the blood vessels, but it is difficult to pass through the skin and enter the internal tissue to measure blood sugar, so the spectral analysis The method of measuring blood glucose is accurate, the selection of the detection site and the location of the blood vessel are the most important, the measurement site The selection criteria should be considered from the following points: 1. Blood enrichment 2. The human body should be selected as much as possible, and it is convenient to measure 3. It is easy to realize the location of optical measurement sampling, and reduce the difficulty of measuring instruments. 4. Consider the parts with small individual differences and minimize The influence of external factors on the measurement results 5. The parts with less interference of internal factors of the human body; according to the test, the tongue, the wall and the eardrum are rich in blood, less water and protein, and less interference because the eardrum membrane microcirculation system has more The blood sugar characteristics, and the surface is free of biological tissue coverage. This creation preferentially selects the eardrum membrane microcirculation system. By collecting the high-magnification laser light reflection image signal from the eardrum, it can accurately distinguish the blood vessel and the living tissue, enabling it to More accurately reflect the blood sugar level; this creation especially refers to a hand-held cover, which has a hardware auxiliary device that allows the user to reach the ear to collect the tympanic image signal, which is included The lens cover and the ear mirror probe device can be used for inserting the ear mirror probe into the ear, and the front lens cover and the ear mirror probe are provided with a combined structure, and the ear mirror probes of different sizes can be replaced. The user can adjust the different size of the ear mirror probe according to actual needs, and at the same time adjust the distance of the object to be measured according to the actual image transmitted by the conjugate focal length microscope, thereby achieving the effect of finely adjusting the focal length; a conjugate focal length microscope, including the structure of the optical machine and An electronic image capturing device, wherein the optical machine structure comprises a front optical fiber holder, a conjugate focal length hood, an LED flood light, a high-magnification lens, a lens holder, a lens focal length adapter, and the like, the light structure component The structural component of the machine can capture a high-magnification image; the electronic image capturing device of the conjugate focal length microscope includes an image sensor, a microprocessor component, an electronic circuit board, and a wireless transceiver module, and the device can be After the image sensor captures the image, the high-magnification image signal reflected by the multi-source laser light of the eardrum is processed by the microprocessor component and stored in the electronic circuit board. The wireless transceiver module is coupled to the remote mobile device, wherein the image sensor is designed as a small-foot-high resolution sensor, wherein the image sensor is 1/5 inches, 1/6 inch. , 1 / 6.5 inches, 1 / 8 inches high resolution CMOS, CCD sensor is the best, so you can get the best high magnification image capture; a wireless transceiver module, the signal wireless and intelligent Contact with remote mobile devices such as mobile phones, tablet computers, and computer cloud devices; a multi-source laser projector that contains a variety of laser engines that emit different wavelengths of laser light and pulsed laser light, and accepts electronic images of conjugate focal length microscopes. The capturing device comprises a microprocessor element operating according to a function switch, sequentially projecting visible light and invisible laser light, and projecting the multi-source laser light onto the eardrum membrane microvessel through a fixed structure of the light guiding fiber and the light guiding fiber. After analyzing the infrared spectrum and pulling By analyzing the spectroscopy of Mann's spectrum, it is possible to quickly measure the blood sugar level to estimate the individual's blood sugar level.

Infrared non-invasive blood glucose detection technology has the advantages of no pain, no risk of infection, rapid measurement, no need for any chemical reagents or consumables, but non-invasive blood glucose meters are still not commercially available, because the near-infrared method requires frequent correction for measuring blood glucose. And the results of the measurement are susceptible to differences in individual factors such as moisture, fat, skin, muscles, bones, drugs taken, hemoglobin concentration, body temperature and nutritional status, which cause the absorption lines of light waves to be very different, so how to analyze and treat different human bodies The error caused by the organization is one of the main factors limiting the accuracy of non-invasive blood glucose measurement in infrared spectroscopy. Another factor is that the previous technology only uses infrared light spectrum to analyze the change of sugar concentration, and the change of diffuse light energy, Actually, the absorption effect and the scattering effect caused by the change of sugar concentration, which comprehensively affect the light propagation behavior, the effects of absorption and scattering effects on the light intensity may be mutually enhanced or canceled at different spatial positions. Detection by a single source of infrared light, often its detection Accuracy of results is still unsatisfactory, due to the above factors so that the infrared light non-invasive blood glucose monitoring technology is still unable to successfully quantify the market.

In view of this creation, the eardrum membrane microcirculation system is preferred, and the position of the microvessels is accurately positioned by using the hand-held casing, and the conjugated focal length microscope is used to The tympanic membrane collects a clear high-magnification image signal, and the micro-vessels are separated from the living tissue image by the above image. At the same time, the multi-source laser light projection is used for the user to obtain the multi-source laser light reflection of the eardrum membrane. The high-magnification image signal is converted into infrared imaging spectrum and Raman imaging spectrum by the APP software of the smart phone. After measuring the infrared spectrum and the Raman spectrum, the spatial resolution and sensitivity are used for analysis and comparison. The glucose content can be quickly measured, and the blood glucose level can be calculated based on the digitized data to estimate the individual's blood glucose level. This creation provides a multi-source microscopic positioning microvascular image of a newly designed non-invasive blood glucose meter. The pick-up device has a user who allows the user to position the video image through the hand-held cover and the ear mirror probe and the LED flood light, and then operates the function switch to emit a multi-source light source from the light guiding fiber device to the eardrum film. Shooting light, collecting from a tympanic membrane through a conjugate focal length microscope to a high-magnification multi-source laser light The image signal of the shot, that is, the wireless signal can be transmitted to the remote mobile device by the wireless signal, and then the blood glucose level can be quickly measured by spectrum analysis to estimate the blood sugar level of the individual; and the non-invasive blood glucose meter The light source micro-positioning magnified micro-vessel image capturing device, in addition to the wireless transceiver module to wirelessly and remotely move the signal, can also output a wired video signal, which can be a computer USB signal or a television HDMI signal reference (fifth) For other indications of this creation, please refer to the (4) diagram, the (6th) related component link corresponding to the schematic block diagram, the (seventh) motion flow diagram; you can understand the microvascular image capture of this non-invasive blood glucose meter. The contents of the device indicate that other features and functions of this creation will be further explained by the following drawings, which will enable your review committee to have a more detailed understanding. The preferred embodiment for explaining the present invention is not intended to limit the present invention in any way.

1‧‧‧Handheld case

11‧‧‧Contact lens hood

11a‧‧‧Front lens hood

11b‧‧‧After lens hood

11c‧‧‧ front and rear lens hood combined switch

12‧‧‧Aurora probe

13‧‧‧Handheld cover upper cover

14‧‧‧Handheld under cover

2‧‧‧ optomechanical structure of conjugate focal length microscope

21‧‧‧Front fiber holder

22‧‧‧LED flood light

23‧‧‧Conjugate focal length hood

24‧‧‧High magnification lens

25‧‧‧ lens mount

26‧‧‧Lens focal length adapter

3‧‧‧Electronic image capturing device for conjugate focal length microscope

31‧‧‧Image Sensor

32‧‧‧Microprocessor components

33‧‧‧Electronic circuit board

34‧‧‧Wireless transceiver module

35‧‧‧Power switch

36‧‧‧Power input board

37‧‧‧ function switch

38‧‧‧Lithium battery

4‧‧‧Multiple source laser light machine

41‧‧‧ visible laser engine

42‧‧‧Invisible laser engine

43‧‧‧Light guiding fiber

43a‧‧‧Fixed structure of light guiding fiber

43b‧‧‧Light guide fiber LED flood light board hanging trunk

43c‧‧‧Light guide fiber splicing trench

The first figure is a perspective view of a multi-source micro-positioning magnified microvascular image capturing device of the non-invasive blood glucose meter; the second figure is a multi-source micro-positioning magnifying microvascular image capturing device of the non-invasive blood glucose meter For example, a stereoscopic view of the optomechanical structure of the conjugate focal length microscope; the third diagram is an embodiment of the multi-source micro-positioning magnifying microvascular image capturing device of the non-invasive blood glucose meter, and a stereoscopic image of the electronic image capturing device of the conjugate focal length microscope; The four pictures are schematic diagrams of the use of the multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter; the fifth picture is the signal of the multi-source micro-positioning magnifying micro-vascular image capturing device of the non-invasive blood glucose meter Transmission diagram; the sixth diagram is the corresponding schematic block diagram of the multi-source micro-positioning micro-vascular image acquisition device of the non-invasive blood glucose meter; the seventh diagram is the multi-source microscopic positioning of the non-invasive blood glucose meter A schematic diagram of the action flow of the magnifying microvascular image capturing device;

The following is a detailed description of how to operate the multi-source micro-positioning micro-vascular image capturing device for how to operate a non-invasive blood glucose meter. As shown in the following figures, (1) to (3), the present embodiment is a multi-source microscopic positioning magnifying microvascular image capturing device installed in a set of hand-held housing structures, and the cover is installed. The shell structure comprises: a hand-held base cover (1), and the cover structure comprises a receiver lens cover (11), the connection lens cover (11) structure comprises a front lens cover (11a), followed by The lens hood (11b) and the front and rear lens hood combination switch (11c) are used in combination with the front and rear lens hoods, and an otoscope probe (12) is inserted into the groove of the front lens hood to be used by the user. The ear canal is sized with a different size of the ear mirror probe (12), a hand-held cover upper cover (13), a hand-held cover lower cover (14) combined into a hand-held cover; a conjugate focal length microscope The optomechanical structure (2) includes a front fiber holder (21) for use as a fixed fiber, and an LED floodlight (22) for illuminating the object to be measured, and a conjugate focal length hood (23) for filtering The optical stray light is used, the high-magnification lens (24) is used for optical microscopic magnification, and the lens mount (25) is used as a fixed high-magnification lens. The adapter (26) is used as the focus adjustment; the electronic image capturing device (3) of a conjugate focal length microscope, the image sensor (31) is used as the image capturing device, and the microprocessor component ( 32) used as electronic image board and image processing, electronic circuit board (33) used for electronic components of electronic image capturing device, wireless transceiver module (34) with wireless two-way transmission function can be wireless with smart phone Communication, power switch (35) is used as power switch, USB input slot on power input board (36) can be used as power input and signal transmission, function switch (37) is used as function selection, lithium battery (38) As a mobile power source; a multi-source laser projector (4), mounted on the lower cover of the hand-held casing, connected by a signal line and an electronic image capturing device of the conjugate focal length microscope, containing a visible light laser The engine (41) can emit continuous laser light of 350-750 nm wavelength and laser pulse visible light, and an invisible light laser engine (42) can emit continuous laser light of 820-1050 nm and laser pulse IR according to the instruction. The invisible light, the light guiding fiber (43), the fixed structure of the light guiding fiber (43a), the light guiding fiber LED flooding plate hanging line groove (43b), and the light guiding fiber hanging line groove (43c) are combined by the above components. The light source microscopic positioning magnifies the microvascular image capturing device; the following describes the operation mode as a detailed description of the implementation of the present invention, first taking out the multi-source microscopic positioning magnifying microvascular image capturing device, and holding the hand-held casing (1) with one hand, Press the power switch (35) to turn on the power. At this time, the LED flood light (22) will light up, insert the ear microscope probe of the handheld base case (1) into the ear canal, and the smart phone with the APP software will be included. When you open it, you can see the image from the display. The lens cover (11) is adjusted to the front and rear of the object to be tested, and the image of the display screen is observed. If the image is not clear, the image is slowly moved back and forth until the image is clear. At this point, the microscopic enlarged image of the eardrum film can be seen. And confirm that the image is a blood vessel gathering area, and the function switch (37) can be operated at this time. At this time, the electronic image capturing device of the conjugate focal length microscope, the microprocessor component contained therein, will issue an instruction according to the function switch operation. The multi-source laser light engine is sequentially ordered to project visible light and invisible laser light to the eardrum membrane microvessels. At this time, the electronic image capturing device (3) of the conjugate focal length microscope will magnify the multi-source laser light reflection of the eardrum membrane. The multiplying image signal is stored, and the micro-vessel image is transmitted to the smart phone by the wireless transceiver module. At this time, the smart phone user obtains the multi-source lightning of the eardrum film. The high-magnification image signal of the light reflection is converted into an APP software of infrared spectrum and Raman spectrum by using the image signal, and converted into an infrared imaging spectrum and a Raman imaging spectrum to obtain a blood sugar value.

11‧‧‧Contact lens hood

11a‧‧‧Front lens hood

11b‧‧‧After lens hood

11c‧‧‧ front and rear lens hood combined switch

12‧‧‧Aurora probe

2‧‧‧ optomechanical structure of conjugate focal length microscope

21‧‧‧Front fiber holder

22‧‧‧LED flood light

23‧‧‧Conjugate focal length hood

24‧‧‧High magnification lens

25‧‧‧ lens mount

43‧‧‧Light guiding fiber

43a‧‧‧Fixed structure of light guiding fiber

43b‧‧‧Light guide fiber LED flood light board hanging trunk

43c‧‧‧Light guide fiber splicing trench

Claims (16)

A multi-source micro-positioning magnifying micro-vessel image capturing device for a non-invasive blood glucose meter, which fixes the device in the external auditory canal through a LED projection lamp and an otoscope probe in a hand-held cover, using a conjugate focal length microscope The image signal output by the electronic image capturing device and the display screen of the remote mobile device accurately position the microvascular position of the subject, and then the user operates to command a plurality of laser engines in the multi-source laser to emit laser light. The multi-source laser light is sequentially emitted to the eardrum through the light guiding optical fiber, and then the electronic image capturing device of the conjugate focal length microscope is sequentially collected, and the micro-angiographic signal of the eardrum membrane is sequentially collected, and the microvascular image captured by the wireless transceiver module is captured. The signal is sent to the remote mobile device, and the user performs spectrum operation analysis by the APP software and displays the blood glucose value; the creation includes: an electronic image capturing device of the conjugate focal length microscope, which contains the image sense Detector, microprocessor component, electronic circuit board, wireless transceiver module, the device can capture images through the image sensor The high-magnification image signal reflected by the multi-source laser light of the eardrum is processed by the microprocessor component and stored in the electronic circuit board, and the wireless transceiver module and the remote mobile device are connected; a hand-held casing The front lens cover and the ear mirror probe are combined and fixed on the front cover of the hand cover and the front end of the lower cover by the rear lens cover, and the optomechanical structure of the conjugate focal length microscope is covered therein; The illuminator structure of the yoke focal length microscope includes: front fiber holder, LED flood light, conjugate focal length hood, high magnification lens, lens holder, lens focal length adapter, etc., which can be used as conjugate focal length. Optical magnification of the microscope; a multi-source laser projector contains a variety of laser engines mounted on the lower cover of the hand-held casing, with signal lines and conjugate focal lengths The electronic image capturing device of the microscope is coupled, and the microprocessor component included in the electronic image capturing device of the conjugate focal length microscope is controlled by the function switch, sequentially projecting visible light and invisible laser light, and guiding the optical fiber through the light guiding fiber and The fixed structure of the light guiding optical fiber projects the multi-source laser light to the ear vein membrane micro-vessel, and is used as a light source, so that the user can obtain the high-magnification image signal of the tympanic membrane laser light reflection; through the above structural device, the precise positioning of the ear is taken The tympanic membrane is rich in microvascular areas, so that the microvessels can be separated from the living tissue images, allowing the conjugate focal length microscope to be accurately positioned from the eardrum membrane, and the micro-vessels can be wirelessly imaged with high-magnification multi-source laser light reflection. The signal transmits the captured microvascular image to the remote mobile device, and then converts the image signal into an infrared spectrum and an Raman spectrum APP software, and converts the image into an infrared imaging spectrum and a Raman imaging spectrum to estimate the individual. Blood glucose level; another non-invasive blood glucose meter multi-source microscopic positioning magnifies microvessels Image capture means, in addition to the wireless signal transceiver module in a wireless manner and a distal end mobile devices, which may output video signal may be a wired computer USB HDMI signal or television signal. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, wherein the electronic image capturing device of the conjugate focal length microscope has a conjugate focal length hood to eliminate the focal length A conjugate focal length microscope for external optical noise. A multi-source micro-positioning magnifying micro-vascular image capturing device for a non-invasive blood glucose meter according to claim 1 of the patent application, wherein the conjugate focal length microscope optical machine The structure is arranged with a front optical fiber holder, a conjugate focal length hood, an LED flood light, a high-magnification lens, a lens holder, a lens focal length adapter and the like to obtain a high-magnification image. The multi-source micro-positioning magnifying micro-vascular image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, wherein the electronic image capturing device of the conjugate focal length microscope includes the image sensor 1/ 5 inch, 1/6 inch, 1/6.5 inch, 1/8 inch high resolution CMOS sensor. The multi-source micro-positioning magnifying micro-vascular image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, wherein the electronic image capturing device of the conjugate focal length microscope includes the image sensor 1/ 5 inches, 1/6 inch, 1/6.5 inch, 1/8 inch high resolution CCD sensor. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application is through a hand-held casing and an ear mirror probe, an LED flood light, and the like, and an auxiliary hardware device. Accurate positioning of the ear vein membrane microvessels. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application is characterized in that the multi-source laser light is used to illuminate the eardrum membrane microvessels with different light sources multiple times, and then conjugated. The focal length microscope is collected from the eardrum membrane, and the high-magnification multi-source laser light reflects the image signal. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, the multi-source laser light machine comprising a visible light laser engine capable of emitting 350-750 nm of the wavelength according to the instruction Continuously visible laser light as well as laser pulse visible light. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to claim 1 of the patent application scope, wherein the multi-source laser light machine comprises an invisible light laser engine capable of issuing 820-1050 nm according to the instruction. Continuous invisible laser light of wavelength and laser irradiance of laser pulse. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to claim 9 of the patent application scope, wherein the multi-source laser light machine, the laser light of the multi-source laser light machine is via the light guiding optical fiber And a fixed structure of the light guiding fiber, the multi-source laser light is projected to the eardrum membrane microvessel. The multi-source micro-positioning magnifying micro-vessel image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, the wireless transceiver module can capture the multi-source laser light reflecting image signal by the image capturing device. Delivered to the remote mobile device wirelessly. The multi-source micro-positioning magnifying micro-vascular image capturing device of the non-invasive blood glucose meter according to claim 1, wherein the wireless transceiver module transmits the captured micro-vessel image to the mobile device, the mobile device is smart A mobile device, a tablet computer, a computer cloud device, a wearable device, and the like, and then use the APP software to convert the image signal into an infrared spectrum and a Raman spectrum, and then calculate the blood sugar level. The multi-source micro-positioning magnifying micro-vascular image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, wherein the ear-mirror probe is a plug-in combination to fix the ear mirror probe to the front object The lens hood allows the user to freely change the size of the ear mirror probe depending on the size of the ear canal. The multi-source micro-positioning micro-angiography image capturing device of the non-invasive blood glucose meter according to claim 1 of the patent application, wherein the output signal is a television HDMI signal. For example, the multi-source micro-positioning micro-angiography image capturing device of the non-invasive blood glucose meter described in claim 1 of the patent application, wherein the output signal is a computer USB signal. The multi-source micro-positioning micro-angiography image capturing device of the non-invasive blood glucose meter according to the first aspect of the patent application, wherein the output signal line output end is a micro USB plug.