TWM245213U - Device for spot-printing minute amount of liquid - Google Patents

Description

V. Creation instructions (1) [Creation area] This creation is about biological wind .. 'Provide-a kind of micro liquid dispensation 2 = or molecular biology and other fields on the biochip to form a micro liquid 置 1, especially Refers to a device that uses dots. [The description of the know-how] for the array of the body array (micorarray). When the biological points are: array ::: =, for example, the majority ::: this 〇 will be directed to each-in order to achieve the material U U on your body 5 Arranged in a grid pattern

For research and analysis. The microarray dot printing K; = the refreshing head 10 in which the slot 101 is placed, and most of them can be slid separately: the dot pins 12 in the slot 101 are inserted. oblique? One end of the μΙΓ needle 12 is formed with a stopper that can be taken into solution and stored ... and a stopper 121 is connected to the other end of the needle 12 to prevent the needle 12 from self-clamping Head 10 drops. , Force, when in the picking position, the chuck 10 drives the spotting needle 12 down to pick up / combine, and when in the spotting position, the chuck 1o drops again to make each dot 1 The pinhole 1 2 of 2 touches the surface of the carrier 5 and spots the soaked solution on the surface of the carrier 5 to complete the microarray spot printing operation. When the micro-printing device 1 is actually used, the weight of the printing needle 12 is used, and at the printing position, the pinhole 丨 2 is used to abut the surface of the carrier 5 to make the printing needle 12 slidable. Move the ground to insert every 10 points of the chuck

丄 VI 厶 叶 J V. Creation instructions (2) The printing needle 12 can be connected to the surface of the carrier 5 at the same time. Make 4, He / Nan transfer to the carrier 5 As far as microcosm is concerned, the 12 pinholes 12 are made by ==; == a microarray dot printing device! The weakest part of the structure of the stylus needle; 7 due to 2 :: jin formation is also the abrasion of the t needle 12 as a whole, so that the tip surface of the stylized valve will produce? F, shape is not-, No subsequent experiments can be performed. Alas, lead to the solution [Creation summary] Handover and inspection. Therefore, the purpose of this creation is to be in place, and it has the consistency and fast effect of liquid dot printing. "Worry", "I have reached the imprint-ancient", a trace liquid imprinting device created by i, which contains -Η »and a chuck with a trough in the valley of the number, and a movement that can be moved in the chuck. Most dots. The end of the marking needle is a cone d: the tip of the head forms a needle tip surface; the needle head is provided with a long through hole for storage, and a plurality of channels are formed from the elongated through hole to the surface of the needle tip. Due to the capillary action, the liquid in the pores flows from these channels to the tip two = a suspension-like droplet, which is then transferred to the surface of the carrier. By using w and mountain as solid body to strengthen and improve the impact resistance of the needle, it has the advantages of high structure and strong output, accurate printing, and can achieve the consistency of the printing point and fast printing. [Detailed description of the preferred embodiment 】 ≫ ° Other features and advantages of this creation will be clearly understood in the following detailed description of the preferred embodiment with reference to the figure. In the drawing, see the second and third pictures. One end of the dot 2 2 is ^ cone

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Shaped needle 221 (can also be a square cone or polygonal cone), the tip of the needle 221 is 'opened' to form a needle tip surface 2 2 2 and the needle 2 2 1 is partially provided with a slender vertical perpendicular to each other The through hole 223 is provided with a plurality of trenches 2 2 4 from the elongated through hole 223 to the needle tip surface 2 2 2. In addition, a stopper 225 is connected to the other end of the dot needle 22. Depending on the printing operation, sometimes a single printing needle 22 is used. When the printing needle 22 is in the picking position, two elongated through holes 223 perpendicular to each other are used as a space for picking up the solution and retaining it. At the spotting position, the liquid in the slender through hole 2 2 3 will flow from the trench 2 2 4 to the needle tip surface 2 2 2 as a suspension droplet due to capillary action, and the droplet will be transferred to the surface of the carrier. To complete the print job. 70 Because the needle tip surface 222 of the printing needle 22 is a solid bracket that is not fully cut and the groove 2 2 4 acts to suspend the droplets on the needle tip surface 2 2 2 first, a non-contact droplet transfer can be generated. In addition to reducing the striking force of the printing needle 22, it can also be mentioned that the striking force during printing will not cause the needle tip surface 2 2 2 to deform and be damaged. Z increases the strength of the structure of the needle 221, and at the same time, the printing effect is good. $ 二 二 状 is hollow like a donut. Please refer to the fourth figure. In the microarray spot printing operation, a chuck 21 having a receiving groove 210 is required, so that the dots 22 can be moved in a straight line and inserted into the chuck 21. A plurality of grooves 226 are formed downwardly on the surface of the marking needle 22, so that the marking needle 22 can smoothly slide in the accommodating groove 21o, and at the same time, ^ is used to exclude the slipping of the marking needle 22. The powder generated by friction in the groove 2 1 〇 and also has the function of exhausting gas, so as to prevent the space between the printing needle 2 2 and the inner wall of the groove 2 1 〇 due to the small distance between them, and they cannot be smoothly absorbed by each other. Slide down. °

Page 6 M245213 V. Creation instructions (4) The lower edge surface of the stopper block 225 of the dot needle 22 faces the top surface of the chuck 21 to prevent the dot needle 2 2 from falling from the chuck 21, therefore, The top of the missing head 21 is a reference plane, and the distance between the lower edge surface of the stop block 22 5 and the needle tip surface is fixed, so that each point of the needle tip surface 222 of the needle 22 forms an oblique small j-plane. 3, can effectively improve the multi-point printing, the large end of the ρ of each point of the needle 22, 222 contact with the carrier (not shown in the picture), the time is different, !! !! To provide multi-point needle 22 Simultaneous use of dot printing, and achieves dot-consistent and fast results. As a result, the trenches 224 are formed by the electric discharge machining method of the circular electrode disk, and the trenches m of W 17 12 2 can be accurately formed corresponding to each other. For two inches, a large number of these tapered needles 221 are produced, and the production of the miscellaneous π 2 can be processed by a mold to accurately prepare these tapered needles 2 2 1 at the same time.山 # τ u 衣 w # 寻 Will not repeat them here. The production method described has been well known in the industry, so 22 = the second micro-quantity; the printing device 2 is a solid cone point printing needle fluid flowing through the trench 224 to the ^ shan elongated through hole 223 to store the solution, And make it into a non-contact, / end face 2 2 2 to form a suspension droplet, and complete and complete the strength of each dehorning needle 221, and can evenly # β ^ the volume and shape of the printing liquid , And can achieve ^ consistent and fast results. . This court to India

At the end, only the preferred embodiment of the creation is &, A x = this: The scope of the implementation of the creation, that is, the simple equivalent changes and modifications not made by M i π ^ Gu should still belong to Within the scope of this creation patent. , L decorated with white

m Page 7 Simple illustration of M245213 diagrams [Simplified description of diagrams] The first diagram is a cross-sectional view illustrating a situation where a micro-array dot printing device with a plurality of dots is inserted to print a liquid on a carrier; Figure 2 is a perspective view of a printing needle of a preferred embodiment of the trace liquid dot printing device created in the present invention; Figure 3 is a partial enlarged view of the second figure, illustrating the structure of a marking needle needle of a trace liquid dot printing device; And the fourth figure is the use state diagram of the trace liquid printing device of this creation.

[Comparison of component numbers] 2 Trace liquid marking device 21 Chuck 210 Receiving slot 22 Point printing needle 221 Needle 222 Needle tip surface 223 Slim through hole 224 Ditch 225 Stopper 226 Groove

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Claims (1)

M245213 6 2 4 7 Scope of patent application • ^ trace liquid dots ~ chucks, the majority of the dots, one of the dots is a needle tip surface; the needle is from an elongated through hole to The dot printing needle falls from the chuck as in the scope of patent application, where the cone is as in the scope of patent application, where the cone is as in the scope of patent application, where the cone is as in the scope of patent application, where the ditch is According to the scope of the patent application, the conical printing device includes: the chuck is provided with a plurality of receiving grooves, and the stomach can be used as a dagger in the accommodating grooves of the chuck as: a conical needle, the tip of the needle 1 ft A slender channel ^ is provided for storing liquid, and a large number of trenches are provided on the large end surface. The micro liquid marking device described in item 1 is provided with a stopper at the other end of the needle to prevent the spotting. 〇 The micro liquid marking device described in item 1 The needle can have a conical shape. The trace liquid dispensing device according to item 1, the needle can be a quadrangular pyramid shape. The trace liquid dispensing device according to item 1, the needle can have a polygonal pyramid shape. The trace liquid marking device described in the first item is formed by an electric discharge machining method of a circular electrode disk. The needle for placing a trace amount of liquid as described in item 1 is formed by a mold. Page 9