TWI841480B - 病毒去活化劑組成物及增加病毒去活化效能之方法,以及病毒去活化之方法 - Google Patents
病毒去活化劑組成物及增加病毒去活化效能之方法,以及病毒去活化之方法 Download PDFInfo
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- TWI841480B TWI841480B TW112132463A TW112132463A TWI841480B TW I841480 B TWI841480 B TW I841480B TW 112132463 A TW112132463 A TW 112132463A TW 112132463 A TW112132463 A TW 112132463A TW I841480 B TWI841480 B TW I841480B
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- virus
- deactivation
- acid
- ethanol
- virus deactivation
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Abstract
本發明的課題為提供一種可減低病毒去活化成分之乙醇的摻合量,病毒去活化效果高且安全性亦優異之病毒去活化劑組成物及病毒去活化效力增強方法、以及病毒去活化方法。
本發明的解決手段為一種病毒去活化劑組成物,其係將作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與作為(B)病毒去活化效力增強成分之選自富馬酸、磷酸、檸檬酸中之1種或2種以上,混合在(C)水而成為酸性水溶液。
Description
本發明係關於將病毒去活化成分摻合在水溶液中而成之病毒去活化劑組成物及病毒去活化效力增強方法、以及病毒去活化方法。
在食品製造及調理施設、醫療施設、教育施設等,因杯狀病毒科之諾羅病毒導致之食物中毒成為問題。作為諾羅病毒之去活化的方法,已知有使用次氯酸鈉溶液之方法,或藉由熱水消毒之方法。惟,於藉由次氯酸之消毒,處理面漂白或是發生惡臭等可用性不佳,由於與酸性型之漂白劑等混用時,產生氯氣故於安全性的面並不充分。又,於熱水消毒,藉由與被消毒物之接觸,導致溫度降低保持所期望的溫度有困難。進而,亦有因熱水導致燙傷之危險。從如此之現狀,正要求安全性高,且病毒去活化效果高之病毒去活化劑。
為了去活化這般的病毒,作為病毒去活化成分,廣泛使用摻合低級醇病毒去活性劑。例如,於專利文獻1中,揭示有至少含有70重量%之乙醇及/或丙醇、與0.5至5重量%之短鏈的有機酸的殺病毒劑。
又,專利文獻2中已揭示一種病毒粒子之去活化法,其係使包含C1-6醇,及選自由陽離子性寡聚物或聚合物、質子供體、離散劑及該等之混合物所成之群組中之增大效果的量之1個以上的增強劑之醇組成物、與不具有包膜之病毒粒子接觸而去活化之方法,其特徵為在醇組成物含有質子供體的情況下,進而含有協同的量之陽離子寡聚物或聚合物,亦記載有將醇濃度定為50質量%以上。
又,於專利文獻3中揭示有一種消毒液,其特徵為包含(A)乙醇50~70重量%、以及(B)選自由有機酸、有機酸鹽及乙醇胺類所成之群組中之至少1種0.05~4.50重量%,pH為6~12。
[先前技術文獻]
[專利文獻]
[專利文獻1]日本特開昭63-14702號公報
[專利文獻2]日本特表2009-526060號公報
[專利文獻3]日本特開2016-210807號公報
[發明欲解決之課題]
然而,專利文獻1~3之病毒去活化劑皆為醇的濃度比較高的濃度,有易燃性或因醇導致之刺激性的問題。因此,有必要注意於廚房周圍等之使用火的場所之使用。又,將包含乙醇之殺菌劑塗佈在樹脂製構件時,亦有發生塗裝或蠟的剝離之虞,亦有對乙醇的氣味不喜歡的人,或以乙醇使得手粗糙的人而言有使用困難的問題點。又,於專利文獻3,pH為6~12時,由於為中性~鹼性,故亦有因鹼導致之腐蝕性的問題。進而,於廚房周圍由於存在食品或食器等,故即使附著在該等,亦期望對健康無影響之安全性高的病毒去活化劑。
本發明係鑑於上述問題點,以提供一種可減低病毒去活化成分之乙醇的摻合量,病毒去活化效果高且安全性亦優異之病毒去活化劑組成物及病毒去活化效力增強方法、以及病毒去活化方法作為目的。
[用以解決課題之手段]
為了達成上述目的,本發明係一種病毒去活化劑組成物,其係將作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與作為(B)病毒去活化效力增強成分之選自富馬酸、磷酸、檸檬酸中之1種或2種以上,混合在(C)水而成為酸性水溶液。
又,本發明在上述構成之病毒去活化劑組成物,其特徵為前述病毒去活化效力增強成分係選自富馬酸、磷酸中之1種或2種。
又,本發明在上述構成之病毒去活化劑組成物,其特徵為前述病毒去活化效力增強成分為富馬酸。
又,本發明在上述構成之病毒去活化劑組成物,其特徵為前述病毒去活化效力增強成分的摻合量為0.05質量%以上。
又,本發明在上述構成之病毒去活化劑組成物,其特徵為前述病毒去活化成分與前述病毒去活化效力增強成分的摻合質量比率(A)/(B)係滿足1.30≦log
10[(A)/(B)]≦3.10。
又,本發明在上述構成之病毒去活化劑組成物,其特徵為作為前述病毒去活化成分,係包含10質量%~40質量%之乙醇。
又,本發明在上述構成之病毒去活化劑組成物,其特徵為作為前述病毒去活化成分,係包含30質量%~60質量%之乙醇。
又,本發明為一種病毒去活化效力增強方法,其特徵為於含有作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與(C)水的病毒去活化劑組成物,添加作為(B)病毒去活化效力增強成分之選自富馬酸、磷酸、檸檬酸中之1種或2種以上。
又,本發明在上述構成之病毒去活化效力增強方法,其特徵為前述病毒去活化效力增強成分係選自富馬酸、磷酸中之1種或2種。
又,本發明在上述構成之病毒去活化效力增強方法,其特徵為前述病毒去活化效力增強成分為富馬酸。
又,本發明在上述構成之病毒去活化效力增強方法,其特徵為前述病毒去活化效力增強成分的添加量相對於前述病毒去活化劑組成物,為0.05質量%以上。
又,本發明為一種非包膜病毒之去活化方法,其係將上述構成之病毒去活化劑組成物對非包膜病毒進行接觸。
[發明效果]
根據本發明之第1構成,係藉由將作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與作為(B)病毒去活化效力增強成分之選自富馬酸、磷酸、檸檬酸中之1種或2種以上,混合在(C)水而成為酸性水溶液,而成為乙醇濃度低之病毒去活化劑組成物。據此,成為不需擔心易燃性或對於皮膚之因乙醇、鹼導致的刺激,並為具備使用感優異,且高病毒去活化效力之病毒去活化劑組成物。
又,根據本發明之第2構成,藉由在上述第1構成之病毒去活化劑組成物,作為病毒去活化效力增強成分,使用選自富馬酸、磷酸中之1種或2種,而成為病毒去活化效力高且安全性亦優異之病毒去活化劑組成物。
又,根據本發明之第3構成,藉由在上述第2構成之病毒去活化劑組成物,作為病毒去活化效力增強成分,使用通用作為化學製品,且安全性亦高,取得容易之富馬酸,以低摻合量可更有效果地提昇病毒去活化成分之乙醇的病毒去活化效力,成為兼備高病毒去活化效力與安全性之病毒去活化劑組成物。
又,根據本發明之第4構成,藉由在上述第1至第3中任一項構成之病毒去活化劑組成物,將病毒去活化效力增強成分的摻合量定為0.05質量%以上,可將病毒去活化效力增強成分的摻合量成為為了充分增強乙醇之病毒去活化效力所必要的摻合量。
又,根據本發明之第5構成,藉由在上述第1至第4中任一項構成之病毒去活化劑組成物,將病毒去活化成分與病毒去活化效力增強成分的摻合質量比率(A)/(B)定為1.30≦log
10[(A)/(B)]≦3.10,可將對於病毒去活化成分之病毒去活化效力增強成分的摻合量成為充分必要的量。
又,根據本發明之第6構成,藉由在上述第1至第5中任一項構成之病毒去活化劑組成物,將病毒去活化成分之乙醇的摻合量定為10質量%~40質量%,成為更一層減低乙醇之氣味或刺激性之使用感優異之病毒去活化劑組成物。
又,根據本發明之第7構成,藉由在上述第1至第5中任一項構成之病毒去活化劑組成物,將病毒去活化成分之乙醇的摻合量定為30質量%~60質量%,成為更一層增強病毒去活化效果的病毒去活化劑組成物。
又,根據本發明之第8構成,藉由於含有作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與(C)水的病毒去活化劑組成物,添加作為(B)病毒去活化效力增強成分之選自富馬酸、磷酸、檸檬酸中之1種或2種以上,可提昇病毒去活化成分之乙醇的病毒去活化效力,成為可製造具備乙醇的摻合量少,且高病毒去活化力之病毒去活化劑組成物。
又,根據本發明之第9構成,藉由在上述第8構成之病毒去活化效力增強方法,作為病毒去活化效力增強成分,使用選自富馬酸、磷酸中之1種或2種,成為可製造病毒去活化效力更高且安全性亦優異之病毒去活化劑組成物。
又,根據本發明之第10構成,藉由在上述第9構成之病毒去活化效力增強方法,作為病毒去活化效力增強成分,使用通用作為化學製品,且安全性亦高,取得容易之富馬酸,以低摻合量可更有效果地提昇病毒去活化成分之乙醇的病毒去活化效力,成為可簡單且低成本製造兼備高病毒去活化效力與安全性之病毒去活化劑組成物。
又,根據本發明之第11構成,藉由在上述第8至第10中任一項構成之病毒去活化效力增強方法,將病毒去活化效力增強成分的摻合量定為0.05質量%以上,可將病毒去活化效力增強成分的摻合量成為為了提昇乙醇之病毒去活化效力所必要的摻合量。
又,根據本發明之第12構成,藉由將上述第1至第7中任一項構成之病毒去活化劑組成物對非包膜病毒進行接觸,成為藥劑感受性低且去活化困難之非包膜病毒的有效果的去活化方法。
以下,針對本發明之病毒去活化劑組成物進行詳細說明。本發明之病毒去活化劑組成物,係將作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與作為(B)病毒去活化效力增強成分之選自特定的有機酸或無機酸中之1種或2種以上,混合在(C)水而成為酸性水溶液者。
已知於本發明之病毒去活化劑組成物,作為病毒去活化成分摻合之(A)乙醇,係具有高病毒去活化效果。惟,藉由併用乙醇、與後述之特定的有機酸及/或無機酸,協同性發揮病毒去活化效力,為本發明者們初次所發現之發現。
在本發明之病毒去活化劑組成物之乙醇的摻合量過少時,有得不到充分病毒去活化效力的可能性。另一方面,摻合量過多時,有易燃性或刺激性增強的問題點。
於本發明之病毒去活化劑組成物,如在後述之實施例所示,為了得到充分之病毒去活化效力,並且減低因乙醇導致之易燃性或刺激性,將乙醇相對於病毒去活化劑組成物全體,以10質量%以上60質量%以下摻合。又,藉由將乙醇相對於病毒去活化劑組成物全體,以10質量%以上40質量%以下摻合,由於可更一層減低乙醇的氣味或刺激性故較佳。又,藉由將乙醇相對於病毒去活化劑組成物全體,以30質量%以上60質量%以下摻合,由於可更一層增強病毒去活化效果故較佳。
作為於本發明之病毒去活化劑組成物,作為(B)病毒去活化效力增強成分摻合之有機酸之具體例,可列舉富馬酸、檸檬酸。作為無機酸之具體例,可列舉磷酸。此等之有機酸及/或無機酸可單獨使用,亦可混合2種以上使用。
上述之有機酸及/或無機酸當中,藉由使用特別是富馬酸、磷酸,以低摻合量可顯著提昇病毒去活化成分之乙醇的病毒去活化效力。
本發明之病毒去活化劑組成物之pH期望為1~6。藉此,病毒去活化劑組成物變為酸性~弱酸性,與鹼性之病毒去活化劑組成物比較,亦無對皮膚之腐蝕性,成為使用感優異之病毒去活化劑組成物。
在本發明之病毒去活化劑組成物之病毒去活化效力增強成分的摻合量,雖並未特別限定,但摻合量過少時,有得不到相對於乙醇的病毒去活化效力之充分增強效果的可能性。
如在後述之實施例所示,為了得到充分之病毒去活化效力增強效果,較佳為將病毒去活化效力增強成分之有機酸及/或無機酸,相對於病毒去活化劑組成物全體,摻合0.05質量%以上,更佳為摻合0.07質量%以上,再更佳為摻合0.1質量%以上。又,較佳為將病毒去活化效力增強成分之有機酸及/或無機酸相對於病毒去活化劑組成物全體,摻合5質量%以下,更佳為摻合2質量%以下,再更佳為摻合1質量%以下。
在本發明,較佳為(A)病毒去活化成分與(B)病毒去活化效力增強成分的摻合質量比率(A)/(B)滿足1.30≦log
10[(A)/(B)]≦3.10,更佳為滿足1.50≦log
10[(A)/(B)]≦3.00,再更佳為滿足2.10≦log
10[(A)/(B)]≦2.90。
於本發明之病毒去活化劑組成物如有必要可摻合界面活性劑。例如,於界面活性劑有產生泡之性質(起泡性),藉由使用起泡性優異之界面活性劑,抑制本發明之病毒去活化劑組成物以觸發噴霧等噴霧在壁面時之液體滴落,並且塗佈區域亦變成容易視別。
作為摻合在本發明之病毒去活化劑組成物之界面活性劑,亦可適合使用陰離子界面活性劑、陽離子界面活性劑、非離子界面活性劑、兩性界面活性劑之任一種。此等當中,除了界面活性作用,可更適合使用亦具有抗病毒作用之陽離子界面活性劑。在本發明之病毒去活化劑組成物中之界面活性劑的摻合量雖並未特別限定,但較佳為0.1質量%以上10質量%以下。
作為陰離子界面活性劑之例,例如可列舉脂肪酸皂、烷基苯磺酸鹽、直鏈烷基苯磺酸鹽、烷基硫酸鹽、α-烯烴磺酸鹽、烷基磷酸酯鹽、聚氧乙烯烷基醚硫酸鹽、聚氧乙烯烷基苯基醚硫酸鹽、聚氧乙烯烷基醚磷酸鹽等。
作為陽離子界面活性劑之例,可列舉月桂基三甲基氯化銨、苯扎氯銨(benzalkonium chloride)、苄索氯銨(benzethonium chloride)、氯化二癸基二甲基銨及氯己定(Chlorhexidine)葡糖酸鹽等之第4級銨鹽。
作為非離子界面活性劑之例,例如可列舉聚氧乙烯烷基醚、聚氧乙烯烷基苯基醚、聚氧乙烯高級脂肪酸酯、聚氧乙烯山梨糖醇脂肪酸酯、聚氧乙烯甘油脂肪酸酯、聚氧乙烯硬化蓖麻油、椰子油脂肪酸二乙醇醯胺、聚氧乙烯聚氧丙烯烷基醚、脂肪酸烷醇醯胺、烷基氧化胺等。
作為兩性界面活性劑之例,可列舉甜菜鹼型界面活性劑。具體而言,可列舉月桂基-N,N-二甲基乙酸甜菜鹼、月桂基醯胺丙基-N,N-二甲基乙酸甜菜鹼、棕櫚烷基醯胺丙基-N,N-二甲基羥基丙基磺基甜菜鹼等。
本發明之病毒去活化劑組成物為水系型,作為溶媒,主要是使用水。作為水,可列舉離子交換水或逆浸透膜水等之純化水,或通常之自來水或工業用水、海洋深層水等。
進而,於本發明之病毒去活化劑組成物,作為其他成分,如有必要可藉由將無機抗菌劑、有機抗菌劑、病毒去活化劑、防藻劑、防銹劑、溶劑、螯合劑、香料、除臭成分、pH調整劑等,在不損害本發明之效果的範圍摻合,以賦予抗菌效果、病毒去活化效果、防藻效果、防銹效果、洗淨效果、芳香性、除臭性等的方式進行。
作為無機抗菌劑、有機抗菌劑、病毒去活化劑之例,可列舉異丙基甲基酚(IPMP)、香芹酚、百里酚、三氯沙(Triclosan)、甲基苯酯(paraben)、乙基苯酯、丙基苯酯、丁基苯酯、4-氯-3,5-二甲基酚、鄰苯基酚、о-甲酚、m-甲酚、p-甲酚、得克利(Tebuconazole)、恩康唑(Enilconazole)、葡萄柚種子萃取物、柿子種子萃取物、葡萄種子萃取物、單月桂酸甘油酯(Monolaurin)、甘油酯(Monocaprin)、單辛酸甘油酯(Monocaprylin)、苯甲酸、山梨酸、甘胺酸、烷基二乙基胺基甘胺酸、聚賴胺酸、去氫乙酸、氯胺、3-碘-2-丙基-N-丁基胺基甲酸酯(Carbamate) (IPBC)、苯氧基乙醇、銀沸石、吡硫鎓鋅(Zinc pyrithione)、硫胺月桂基硫酸鹽、白子蛋白質、羥基烷基殼聚糖、殼聚糖等。
作為防藻劑之例,可列舉二氯異氰脲酸鈉等。作為防銹劑之例,可列舉苯甲酸鈉等。
作為溶劑之例,可列舉正石蠟、異石蠟、流動石蠟、環烷烴系烴、凡士林、鯊烯、α-烯烴寡聚物等之烴系溶劑、1-丙醇、2-丙醇(IPA)、1-丁醇、2-丁醇、第三丁醇、1-戊醇、1-己醇、苄基醇、2-苯基乙醇等之醇系溶劑、2-苯氧基乙醇(乙二醇單苯基醚)、乙二醇、丙二醇、1-苯氧基-2-丙醇(丙二醇苯基醚)、1,3-丁二醇、丙二醇單丁基醚、二丙二醇單丁基醚、三丙二醇單丁基醚等之甘醇系溶劑等。
作為香料之例,可列舉d-檸烯等之檸烯、α-蒎烯、β-蒎烯等之蒎烯、p-對異丙基甲苯(cymene)等之對異丙基甲苯(cymene)、茚、胡蘿蔔素等之烴系香料、芳樟醇、香葉醇、香茅醇、l-薄荷醇等之薄荷醇、乙基芳樟醇、冰片、茴芹醇、β-苯乙基醇、p-薄荷烷-3、8-二醇、α-松油醇、γ-松油醇等之松油醇、1-己醛、順-3-己烯-1-醇、四氫香葉醇、檀香丁烯醇(santalinol)、桂醯基醇、雪松醇等之醇系香料、佳樂麝香(galaxolide)、β-萘基甲基醚、桉葉油醇、降龍涎醚(Ambroxide)、p-甲酚基甲基醚等之醚系香料、茴香腦、丁香油酚、異丁香油酚、香草醛、乙基香草醛等之酚系香料、辛醛、壬醛、十一烷基醛、十一烷醛(Undecanal)、癸基醛、n-丁基醛、異丁基醛、己基醛、檸檬醛、香茅醛、苯甲醛、桂皮醛、茴芹醛、孜然醛、阿道克醛(Adoxal)、戊基桂皮醛、仙客來醛等之醛系香料、肌酮、香芹酮、薄荷酮、樟腦、苯乙酮、丁酸酚酮、吐納麝香(Tonalide)、α-香堇酮、β-香堇酮、α-甲基香堇酮、β-甲基香堇酮、α-異甲基香堇酮、β-異甲基香堇酮、γ-甲基香堇酮、γ-異甲基香堇酮、突厥酮、α-突厥酮、β-突厥酮、乙醯雪松烯、開司米酮(Cashmeran)、順式茉莉酮、二氫茉莉酮等之酮系香料、γ-丁基內酯、γ-壬內酯、γ-癸內酯、γ-十一酸內酯、香豆素、桉葉油醇、黃葵內酯(Ambrettolide)、茉莉內酯(Jasmolactone)等之內酯系香料、甲酸香葉酯、乙酸辛酯、乙酸香葉酯、乙酸苄酯、乙酸桂醯酯、乙酸四氫香葉酯、乙酸薄荷酯、乙酸沉香酯、丙酸丁酯、乙酸苄酯、苯甲酸甲酯、己酸烯丙酯、庚酸烯丙酯、環己烷丙酸烯丙酯、戊基乙醇酸烯丙酯、吉草酸戊酯(valerianate)、水楊酸戊酯、乙酸異戊酯、乙酸丁酯、丁酸乙酯、乙醯基丁香油酚、水楊酸異戊酯、己酸烯丙酯、己酸乙酯、丙酸乙酯、乙醯乙酸乙酯、水楊酸甲酯、乙酸香茅酯、甲酸香茅酯(Citronellyl formate)、乙酸桂醯酯、乙酸硬脂醯酯、丙酸硬脂醯酯、乙酸雪松酯、乙酸萜品酯等之酯系香料、戊基桂皮醛二甲基縮醛、檸檬醛二甲基縮醛等縮醛系香料、吲哚、檸檬腈、香茅腈、乙醛苯基乙基丙基乙酸酯、苯佐那酯(Tessalon)、橙花素(aurantiol)、氧化芳樟醇、薄荷油、橙油、檸檬油、薰衣草油、紙薄荷油、桉樹油、香茅油、萊姆油、柚子油、茉莉油、檜木油、綠茶精油、橙花油、天竺葵油、苦橙葉精油、檸檬草油、肉桂油、檸檬桉樹油、瑞香草油、紫蘇油、松油、玫瑰油、迷迭香油、樟腦油、芳油、鼠尾草油、檀香油、綠薄荷油、大茴香油、熏衣花油、橡木苔油、奧寇梯木油、虎尾草油、香豆酊劑、松節油、杏仁豆酊劑、羅勒油、肉荳蔻油、丁香油、玫瑰木油、香水樹油、小豆蔻油、桂皮油、雪松油、紅橘油、柑油、茴芹油、月桂油、芫荽籽油、欖香脂油、甜茴香油、白松香油、絲柏油、岩蘭草油、佛手柑油、衣蘭油、葡萄柚油、西伯利亞冷杉油、香旱芹油(ajowan oil)、扁桃油、白芷根油、羅勒油(basil oil)、薄荷油、樺木油、花梨木(Rosewood)油、白千層油、香水樹油、辣椒油、香菜油、芹菜油、葡萄渣油、孜然油、蒔蘿油、香艾菊油(estragon oil)、大蒜油、薑油、酒花油、鼠尾草油、松節油等。
除臭成分之例,雖可列舉甘蔗提取物、綠茶萃取提取物、茶乾溜物、柿萃取提取物、葡萄柚萃取提取物、孟宗竹萃取提取物、柚子種子萃取提取物、連翹萃取提取物等,但除了除臭效果,從助長諾羅病毒去活化作用的觀點來看,適合甘蔗提取物。
作為pH調整劑之例,可列舉乙酸、蘋果酸、水楊酸等之其他有機酸、鹽酸等之其他無機酸、檸檬酸鈉、碳酸鈉、碳酸氫鈉、氫氧化鈉等。
藉由將如此所得之本發明之病毒去活化劑組成物,塗佈或是噴霧在接觸病毒感染者的場所、處理病毒感染者之嘔吐物的場所、衣服等之被病毒污染的場所,可有效果地去除病毒。而且,本發明之病毒去活化劑組成物藉由將具有易燃性、刺激性之乙醇的摻合量抑制在10~60質量%,由於可安全且簡單施用,故為實用性極為高者。
又,本發明之病毒去活化組成物除了流感病毒、冠狀病毒、疱疹病毒等之包膜病毒,即使對於諾羅病毒、輪狀病毒、鼻病毒、腺病毒等之非包膜病毒亦具有高去活化效果。據此,於以往之病毒去除劑,可適合使用在去活化困難之諾羅病毒的去活化。
又,本發明之病毒去活化劑組成物作為病毒去活化成分,僅為將乙醇、與作為病毒去活化效力增強成分之特定的有機酸及/或無機酸摻合在水,而成為酸性水溶液之非常單純的組成。因此,除了製造簡便,由於乙醇濃度亦低至60質量%以下,為酸性,故於多數病毒去活化劑成為問題之乙醇的氣味或對皮膚之刺激性亦縮小,係安全性極為高者。又,由於亦無因銀離子導致之變色的問題,故使用性亦優異。
尚,本發明並非被限定於上述之實施形態者,於請求項所示之範圍可進行各種變更,針對適宜組合不同實施形態分別所揭示之技術的手段所得之實施形態,亦包含在本發明之技術範圍。以下,藉由實施例針對本發明之效果進一步具體說明,但本發明並非被制約在此等之實施例者。
[實施例1]
[試驗液的調製]
將(A)乙醇(和光純藥工業公司製)、(B)富馬酸、磷酸、檸檬酸一水合物(以上為和光純藥工業公司製)以表1、表3所示之摻合比例(質量%)摻合,加入純化水,而得到作為100質量%之試驗液(本發明1~12)。
將(A)乙醇(和光純藥工業公司製)(B)富馬酸、磷酸、檸檬酸一水合物、乳酸、苯甲酸、磷酸三鈉、檸檬酸三鈉二水合物(以上為和光純藥工業公司製)、富馬酸二鈉(東京化成品工業公司製)以表2、表4所示之摻合比例(質量%)摻合,加入純化水,而得到作為100質量%之試驗液(比較例1~16)。
[實施例2]
[病毒去活化效果之確認試驗1(Feline calicivirus)]
(試驗病毒液的調製)
使用於MEM培養基(Nacalai Tesque公司製)加入10%胎牛血清之細胞增殖培養基,並將CRFK細胞(JCRB細胞庫)單層培養在組織培養皿內。從單層培養皿內去除細胞增殖培養基,接種貓杯狀病毒(Feline calicivirus F-9 ATCC VR-782)。接著,加入於MEM培養基加入2%胎牛血清之細胞維持培養基,以37±1℃之碳酸氣體培養箱(CO
2濃度5%)內培養1~5天。貓杯狀病毒為非包膜病毒之一種,被作為無法細胞培養之諾羅病毒的代替病毒廣泛使用。
培養後,使用倒置相差顯微鏡,觀察細胞的形態,確認於細胞引起形態變化(細胞變性效果)。接著,將培養液以1000rpm離心分離3分鐘,超微過濾所得之上清液作為試驗病毒液。
於實施例1調製之本發明1~7、比較例1~11之試驗液0.9mL添加混合試驗病毒液0.1mL,作為作用液。1分鐘後將作用液以MEM培養基稀釋100倍,製作10倍稀釋系列。尚,將於純化水添加試驗病毒液者作為對照,進行同樣的操作。
(病毒感染力價的測定)
使用細胞增殖培養基,將使用細胞於組織培養用微孔板(96孔)內單層培養後,去除細胞增殖培養基,每0.1mL加入細胞維持培養基。接著,將作用液之10倍稀釋系列0.1mL分別接種在每4孔,於37±1℃之碳酸氣體培養箱(CO
2濃度5%)內培養4~7天。培養後,使用倒置相差顯微鏡,觀察細胞的形態變化(細胞變性效果)的有無,藉由Reed-Muench法算出50%細胞培養感染量(TCID
50),換算成作用液每1mL之感染力價,與作為對照之純化水的感染力價比較,算出感染力價對數減少值。
病毒去除效果之評估基準係將感染力價對數減少值為1以下的情況定為×,較1更大且為1.5以下的情況定為△,較1.5更大且為3以下的情況定為○,較3更大的情況定為◎。將病毒感染力價之評估結果與試驗液之摻合、pH、log
10[(A)/(B)]、感染力價對數減少值一併示於表1、表2。
如表1所示,於摻合(A)10質量%~40質量%之乙醇、與(B)0.05質量%~0.5質量%之富馬酸、磷酸、檸檬酸一水合物中之任一者的本發明1~7,確認對於貓杯狀病毒(Feline calicivirus),感染力價對數減少值變成較1.5更大,具有病毒去活化效果。
尤其是於將乙醇的摻合量定為40質量%、富馬酸的摻合量分別定為0.2質量%、0.1質量%之本發明1、2及乙醇的摻合量定為40質量%、磷酸的摻合量定為0.05質量%之本發明5,確認感染力價對數減少值變成較3更大,得到更一層顯著之病毒去活化效果。又,由本發明1~7及比較例1~5之結果,單獨摻合乙醇時,分別單獨摻合富馬酸、磷酸、檸檬酸一水合物時,感染力價對數減少值未滿1,雖觀察不到病毒去活化效果,但藉由摻合乙醇與富馬酸、磷酸、檸檬酸一水合物,確認協同性提高病毒去活化效果。
又,由乙醇的摻合量為10質量%、磷酸的摻合量為0.5質量%之本發明6,及乙醇的摻合量為5質量%、磷酸的摻合量為0.5質量%之比較例8的結果,藉由乙醇的摻合量定為10質量%以上,確認藉由磷酸的摻合,協同性提高病毒去活化效果。
又,由乙醇的摻合量為40質量%、磷酸的摻合量為0.05質量%之本發明5,及乙醇的摻合量為40質量%、磷酸的摻合量為0.02質量%之比較例7的結果,藉由將磷酸的摻合量定為0.05質量%以上,確認表現藉由乙醇之病毒去活化效力的增強效果。
又,於取代富馬酸、磷酸、檸檬酸一水合物,改摻合0.2質量%乳酸、苯甲酸、富馬酸二鈉之比較例9~11,感染力價對數減少值分別成為1.5、0.7、1.33,觀察不到充分之病毒去活化效果。
[實施例3]
[病毒去活化效果之確認試驗2(Feline calicivirus)]
(試驗病毒液的調製)
使用於MEM培養基(Nacalai Tesque公司製)加入10%胎牛血清之細胞增殖培養基,將CRFK細胞(JRBC細胞庫)單層培養在組織培養皿內。從單層培養皿內,去除細胞增殖培養基,接種貓杯狀病毒(Feline calicivirus F-9 ATCC VR-782)。接著,加入於MEM培養基加入2%胎牛血清之細胞維持培養基,於37±1℃之碳酸氣體培養箱(CO
2濃度5%)內培養1~5天。
培養後,使用倒置相差顯微鏡,觀察細胞的形態,確認於細胞引起形態變化(細胞變性效果)。接著,將培養液以1000rpm離心分離3分鐘,將所得之上清液作為病毒漂浮液。將病毒漂浮液、與過濾器滅菌之20%肉類提取物水溶液以3:1混合者作為試驗病毒液。於試驗病毒液作為負荷,包含有5%之肉類提取物。
於實施例1調製之本發明8~12、比較例12~16之試驗液0.9mL,添加混合試驗病毒液0.1mL作為作用液。於1分鐘後將作用液以MEM培養基稀釋100倍,製作10倍稀釋系列。尚,將於純化水添加試驗病毒液者作為對照,進行同樣的操作。
病毒感染力價之測定方法、評估基準定為與實施例2相同。將病毒感染力價之評估結果與試驗液之摻合、pH、log
10[(A)/(B)]、感染力價對數減少值一併示於表3、表4。
如表3所示,於摻合(A)40質量%~60質量%之乙醇、與(B)0.05質量%~0.2質量%之富馬酸、磷酸、檸檬酸一水合物中之任一者的本發明8~12,確認對於貓杯狀病毒(Feline calicivirus),感染力價對數減少值變成2.5以上,即使有藉由肉類提取物之負荷的情況,亦得到即效的病毒去活化效果。
對此,如表4所示,於單獨摻合60質量%乙醇之比較例12、乙醇的摻合量為60質量%、磷酸的摻合量為0.02質量%之比較例13,確認感染力價對數減少值變成未滿1,觀察不到病毒去活化效果。又,於取代富馬酸、磷酸,改摻合富馬酸二鈉、磷酸三鈉之比較例14、15,感染力價對數減少值分別成為1.43、1.24,觀察不到充分之病毒去活化效果。進而,於比較例15,試驗液之pH為12.51時成為強鹼性,擔心因鹼導致之腐蝕性或手粗糙的問題。
又,於取代檸檬酸一水合物,改摻合檸檬酸三鈉之比較例16,感染力價對數減少值成為1.93,雖觀察到病毒去活化效果,但試驗液之pH為9.15時,成為鹼性,擔心因鹼導致之腐蝕性或手粗糙的問題。
由以上之結果,藉由將乙醇、與選自富馬酸、磷酸、檸檬酸一水合物中之1種或2種以上,摻合在水成為酸性水溶液,確認具有對於貓杯狀病毒之充分的病毒去活化效果,成為安全性亦優異之病毒去活化劑組成物。
又,藉由富馬酸、磷酸、檸檬酸一水合物與乙醇一起摻合,確認作為乙醇之病毒去活化效力增強成分進行作用。
尚,於此,雖未顯示對於藉由本發明之病毒去活化組成物的包膜病毒之去活化效果,但由於包膜病毒與非包膜病毒相比較,對於藥劑之感受性高,故當然本發明之病毒去活化組成物對於包膜病毒,亦具有即效的去活性效果。
本發明係病毒去活化成分之乙醇濃度比較低,於酸性~弱酸性安全性亦優異之病毒去活化劑組成物及病毒去活化效力增強方法、以及病毒去活化方法,尤其是適合作為藉由直接噴霧等塗佈在被病毒污染之場所等的病毒去活化劑組成物使用。
Claims (5)
- 一種病毒去活化劑組成物,其係將作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與作為(B)病毒去活化效力增強成分之0.05質量%~0.5質量%之選自磷酸、檸檬酸中之1種或2種以上混合在(C)水,而成為酸性水溶液,前述病毒去活化成分與前述病毒去活化效力增強成分的摻合質量比率(A)/(B)滿足1.30≦log10[(A)/(B)]≦3.10(惟,排除包含檸檬酸或磷酸與均苯三酚聚合物的情況、包含檸檬酸與柿子萃取物的情況、包含檸檬酸或磷酸與甘油脂肪酸酯與葡萄柚種子萃取物的情況、包含檸檬酸或磷酸與凝聚劑的情況、包含檸檬酸與乳酸與含鋅化合物的情況)。
- 如請求項1之病毒去活化劑組成物,其中,作為前述病毒去活性成分,係包含10質量%~40質量%之乙醇。
- 如請求項1或請求項2之病毒去活化劑組成物,其中,作為前述病毒去活性成分,係包含30質量%~60質量%之乙醇。
- 一種體外之病毒去活化效力增強方法,其特徵為於含有作為(A)病毒去活化成分之10質量%~60質量%之乙醇、與(C)水的病毒去活化劑組成物,添加作為(B)病毒去活化效力增強成分之0.05質量%~0.5質量%之選自磷酸、檸檬酸中之1種或2種以上(惟,排除前述病毒去活化劑組成物包含均苯三酚聚合物,添加檸檬酸或磷酸的 情況、前述病毒去活化劑組成物包含柿子萃取物,添加檸檬酸的情況、前述病毒去活化劑組成物包含甘油脂肪酸酯與葡萄柚種子萃取物,添加檸檬酸或磷酸的情況、前述病毒去活化劑組成物包含凝聚劑,添加檸檬酸或磷酸的情況、前述病毒去活化劑組成物包含乳酸與含鋅化合物,添加檸檬酸的情況)。
- 一種體外之非包膜病毒之去活化方法,其係將如請求項1至請求項3中任一項之病毒去活化劑組成物對非包膜病毒進行接觸。
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