TWI836188B - Compositions of ingredients for the treatment of stress, psychological trauma or physical fatigue - Google Patents

Abstract

The present invention is a composition for treating stress, psychological trauma or physical fatigue, which comprises: 10-20 μmol/L methylcobalamin, 20-30 μmol/L adenosylcobalamin, 5-8 mmol/L niacinamide, 700-1200 μmol/L pyridoxine, 150-250 μmol/L riboflavin-5-sodium phosphate, 70-150 μmol/L thiamine hydrochloride, 1-2 mmol/L magnesium chloride, 1-2 μmol/L calcium chloride and 2-3 mmol/L potassium chloride in an isotonic saline solution. The isotonic saline solution refers to an isotonic saline solution with a concentration of 0.9%. The present invention mainly utilizes a composition of vitamins, amino acids and electrolytes to treat stress symptoms or physiological or psychological symptoms caused by excessive physical fatigue.

Description

Combinations of ingredients for treating stress, psychological trauma or physical fatigue

The present invention is an ingredient composition for treating stress, psychological trauma or physical fatigue, especially a composition utilizing vitamins, amino acids and electrolytes.

Symptoms of general stress and those caused by physical overexertion are usually treated with rest, which allows the patient to relax and recover; long-term treatments for stress, trauma, and physical overexertion are to recommend a balanced diet, regular rest, and moderate exercise.

These treatment methods can be generally divided into physical health care (but not fixed) and mental health care. The medical community also recognizes that the feedback of mental health status to physical health status is an interaction; therefore, it can be further inferred that part of consciousness will have an effect on the subconscious, and can also be used to regulate or control the nervous system. This regulation will bring a state of relaxation and promote the metabolic process. The effects of relaxation and metabolism will make the consciousness produce an overall sense of well-being, so there is a strong interaction between psychology and physiology. In order for patients to return to normal faster after stress, psychological trauma or physical over-fatigue, it is necessary to find a suitable combination of components with an effective regulatory mechanism in this mutually influencing system for treatment.

It is well known that amphetamines can be used to promote recovery after or during cancer treatment, and the subjective emotional enhancement brought about by the use of amphetamines can indeed cause a reaction in the body and allow patients to recover faster; but the use of amphetamines is not without problems. The key is that amphetamines are addictive to users and patients cannot always maintain their judgment under the influence of amphetamines.

In addition, in order to allow soldiers who often feel stress and psychological shock to serve normally, it is not advisable to use stimulants for long-term treatment; for competitive athletes, they are often unable to protect their bodies during training, resulting in injuries, but synthetic drugs cannot be used. Treatment, as these agents are often considered stimulants and many are prohibited in sports.

The present invention mainly utilizes a composition composed of vitamins, amino acids and electrolytes to treat stress symptoms or physiological or psychological symptoms caused by excessive physical fatigue.

A composition for treating stress, psychological trauma or physical fatigue, comprising: 10-20μmol/L methylcobalamin, 20-30μmol/L adenosylcobalamin, 5-8mmol/L niacinamide, 700-1200μmol/L pyridoxine, 150-250μmol/L riboflavin-5-sodium phosphate, 70-150μmol/L thiamine hydrochloride, 1-2mmol/L magnesium chloride, 1-2μmol/L calcium chloride and 2-3mmol/L potassium chloride in an isotonic saline solution; wherein the osmotic saline solution refers to an isotonic saline solution with a concentration of 0.9%.

In order to enable the review committee to have a deeper understanding of the technical features of the present invention, a specific implementation example is given below with accompanying drawings for detailed description.

The first picture is the overall analysis of the results of the questionnaire scores of all testers on the physical health-related issues in the questionnaire (1).

Figure 2 is a general analysis of the scores of all test takers on questions related to physical health in the questionnaire (Part 2).

The third picture is the overall analysis chart (1) based on the questionnaire scoring results of all testers on mental health-related issues in the questionnaire.

Figure 4 is a general analysis of the questionnaire scores of all test takers on questions related to mental health (Part 2).

Figure 5 is an analysis chart of the questionnaire score results based on the quality of life status filled in by all testers before using the present invention and four weeks after using it (1).

Figure 6 is an analysis chart (2) of the questionnaire score results based on the quality of life status filled in by all testers before using the present invention and four weeks after using it.

Figure 7 is an analysis chart (1) of the questionnaire score results based on the health status satisfaction filled in by all testers before using the present invention and four weeks after using it.

Figure 8 Analysis of the results of the questionnaire rating of health satisfaction filled out by all test subjects before and four weeks after using the invention (II).

Figure 9. Analysis chart (1) of the questionnaire scores (values are negative values) filled out by all testers on the degree of impact of physical pain on daily life before using the present invention and four weeks after use.

Figure 10 Analysis of the results of the questionnaire scores filled out by all test subjects on the degree of influence of physical pain on daily life before and four weeks after using the present invention (values are negative) (II).

Figure 11 Analysis of the results of the questionnaire scores (negative values) on the degree of medical assistance needed in daily life filled out by all test subjects before and four weeks after using the invention (I).

Figure 12. Analysis chart (2) of the questionnaire scores (values are negative) based on the degree of medical help needed in daily life filled out by all testers before using the present invention and four weeks after use.

Figure 13 Analysis of the results of the questionnaire rating of daily life satisfaction filled out by all test subjects before and four weeks after using the invention (I).

Figure 14 is an analysis chart (2) of the questionnaire score results based on the daily life satisfaction filled in by all testers before using the present invention and four weeks after using it.

Figure 15. Analysis chart of the questionnaire score results based on the degree of meaningfulness of daily life filled in by all testers before using the present invention and four weeks after use (1).

Figure 16 Analysis of the results of the questionnaire rating of the meaningfulness of daily life filled out by all testers before and four weeks after using the invention (II).

Figure 17. Analysis chart (1) of the questionnaire score results based on the mental concentration and concentration ability filled out by all testers before using the present invention and four weeks after using it.

Figure 18. Analysis chart (2) of the questionnaire score results based on the mental concentration and concentration ability filled in by all testers before using the invention and four weeks after using it.

Figure 19 Analysis of the results of the questionnaire rating of the feeling of having enough energy in daily life filled out by all test subjects before and four weeks after using the invention (I).

Figure 20 Analysis of the results of the questionnaire rating of the feeling of having enough energy in daily life filled out by all testers before and four weeks after using the invention (II).

Figure 21 Analysis of the results of the questionnaires on the physical fitness (ability) performance of all test subjects before and four weeks after using the invention (I).

Figure 22: Body measurements filled in by all testers before using the invention and four weeks after use Analysis chart of questionnaire score results of physical ability (strength) performance status (2).

Figure 23. Analysis chart (1) of the questionnaire score results based on the ability of all test subjects to fill out the questionnaire before using the invention and four weeks after using it.

Figure 24: Analysis chart of the questionnaire scores based on the ability of all testers to go out before using the invention and four weeks after using it (2).

Figure 25 is an analysis chart of the results of the questionnaire scores on sleep satisfaction filled out by all testers before using the present invention and four weeks after using it (1).

Figure 26 is an analysis chart of the score results of the questionnaire on sleep satisfaction filled out by all testers before using the present invention and four weeks after using it (2).

Figure 27 Analysis of the results of the questionnaires on the ability to perform daily activities filled out by all test subjects before and four weeks after using the present invention (I).

Figure 28: Analysis of the questionnaire score results based on the ability to perform daily activities filled in by all testers before using the invention and four weeks after using it (2).

Figure 29 Analysis of the results of the questionnaires on work performance satisfaction filled out by all test subjects before and four weeks after the use of the present invention (I).

Figure 30: Analysis of the questionnaire scores based on the work ability satisfaction filled out by all testers before using the invention and four weeks after using it (2).

Figure 31 Analysis of the results of the self-satisfaction questionnaires filled out by all testers before and four weeks after using the invention (I).

Figure 32 Analysis of the results of the questionnaire rating based on the self-satisfaction level filled out by all testers before and four weeks after using the invention (II).

Figure 33: before using the invention and four weeks after using it based on the results filled in by all testers Analysis chart of questionnaire score results on the frequency of negative emotions (1).

Figure 34: Analysis of the questionnaire score results based on the frequency of negative emotions filled in by all testers before using the present invention and four weeks after using it (2).

Embodiment 1, please refer to Figures 1 to 34; an ingredient composition for treating stress, psychological trauma or physical fatigue, in an isotonic saline solution, containing: 10-20 μmol/L methyl cobalt Amine, 20-30μmol/L adenosylcobalamin, 5-8mmol/L nicotinamide, 700-1200μmol/L pyridoxine, 150-250μmol/L riboflavin-5-sodium phosphate and 70-150μmol /L thiamine hydrochloride and electrolyte 1-2mmol/L magnesium chloride, 1-2μmol/L calcium chloride and 2-3mmol/L potassium chloride; among them, the osmotic pressure saline solution is used with a concentration of 0.9%, etc. Osmotic saline solution.

The composition can further include the first other active ingredient: 4-8mmol/L phenylalanine, 5-10mmol/L N-acetyl-L-tyrosine, 30-50mmol/L L-arginine, 20-40mmol/L taurine, 30-70mmol/L glycine, 10-30mmol/L L-carnitine, 2-5mmol/L L-carnosine and 30-50mmol/L L-lysine, to form the first other active ingredient composition.

The ingredient composition can further comprise a second other active ingredient: 10-30mmol/L L-isoleucine, 20-40mmol/L L-leucine, 10-30mmol/L L-lysine hydrochloride, 5-15mmol/L L-methionine, 10-25mmol/L L-phenylalanine, 10-25mmol/L L-taurine, 10-30mmol/L L-threonine, 2-5mmol/L L-tryptophan and 20-40mmol /L L-Valine becomes the second other active ingredient composition.

The ingredient composition, the first other active ingredient composition and the second other active ingredient composition all use sodium hydroxide and hydrochloric acid to adjust the concentration to between 0.5-2mmol/L and The pH value is between 6.5-7.5.

The first other active ingredient combination can be used in a drug for treating stress disorders such as fatigue syndrome, attention deficit hyperactivity disorder, fatigue, and chronic fatigue syndrome. The second other active ingredient combination can be used in a drug for treating symptoms of excessive fatigue caused by alcohol or drug abuse; or can be used in a drug for treating symptoms of excessive fatigue caused by strenuous exercise or muscle training.

The treatment for general stress symptoms and symptoms caused by physical overstrain is usually rest, which allows the patient to recover to his original state through relaxation; and for long-term treatment of stress, trauma and physical overstrain, patients are advised to eat a balanced diet, rest regularly and exercise moderately. These treatment methods can be generally divided into physical health care (but not fixed) and mental health care. The medical community also recognizes that the feedback of mental health status to physical health status is an interaction; therefore, it can be further inferred that part of consciousness will have an effect on the subconscious, and can also be used to regulate or control the nervous system. This kind of regulation will bring about a state of relaxation and promote the metabolic process. The effects of relaxation and metabolism will make the consciousness produce an overall sense of well-being, so there is a strong interaction between psychology and physiology.

The external environment in which patients live makes it impossible to always maintain a state of life that is considered healthy. Therefore, it is best to provide patients with a treatment method when they are in an unhealthy stage of life. This treatment method will neither Addiction will not impair the patient's judgment, and it will not be considered a stimulant that is not allowed to be taken. It can also be used as a long-term treatment method.

Comprehensive research reports on vitamins and their effects indicate that taking vitamins within a certain period of time can make up for nutritional deficiencies caused by daily diet or lifestyle. These studies are based on the action principles of pure substances or individual effective substances and are widely used in the West. Widely used in medicine Use; in contrast, traditional Chinese medicine is based on mixtures of substances, and these mixtures are often observed through long-term practice and spread through literature or word of mouth.

In addition, according to research, the human intestine also plays a key role in overall happiness, mainly because serotonin can be synthesized in the intestine; serotonin is a neurotransmitter, and the level of serotonin in the body has a great impact on the patient's subjective happiness. Among them, if the serotonin level in the human intestine is lower than the normal standard, it will cause persistent depression; this is why a balanced diet and moderate exercise that can promote intestinal peristalsis play an important role in the generation of happiness.

Therefore, in order to enable patients to recover to normal state more quickly after stress, psychological trauma or physical fatigue, the present invention mainly utilizes a composition of ingredients composed of vitamins, amino acids and electrolytes, and can be used to treat physiological or psychological symptoms caused by stress, psychological trauma or physical fatigue by using a composition of ingredients that can effectively regulate the mechanism in this mutually influential system.

The use of this ingredient combination can promote the production of serotonin in the intestines. When the serotonin level in the body rises, the patient will feel a stronger sense of well-being. This sense of well-being can increase human activity and promote the body's metabolism through natural purification, thereby removing the final products of body tissue metabolism. Through this cycle, it can achieve a self-enhancement effect to effectively reduce stress symptoms, psychological trauma and physical fatigue. Among them, the experimental observation results based on the long-term use of this ingredient combination on soldiers and competitive athletes clearly found that the single effect of vitamins, that is, taking a single substance alone, is different from the effect produced by taking a specific mixture.

The ingredient combination in the first other active ingredient composition or the second other active ingredient composition is a necessary active ingredient combination because it can be used together during use Significantly increase or enhance the effectiveness of the first other active ingredient or the second other active ingredient. And after using a questionnaire designed by WHO (World Health Organization) to conduct a questionnaire survey on more than 600 patients regarding their overall feelings before and after using the present invention, it was found that the first other active ingredient and the second other active ingredient are Effective.

The first other active ingredient in the first other active ingredient composition can provide the effect of stabilizing subjective emotions when used together with the ingredient composition. Therefore, the first other active ingredient has an auxiliary effect in treating stress symptoms and psychological trauma; and the typical manifestations of reducing severe stress include: improved cognitive function (attention, perception), mental and physical satisfaction, improved physical condition, and reduced stress symptoms (such as hair loss, stomach pain, and sleep disorders).

The second other active ingredient in the second other active ingredient composition, when used together with the ingredient composition, can provide a faster recovery effect from excessive physical fatigue, thereby reducing physical fatigue after high-intensity training or strenuous physical exercise. Symptoms of fatigue. The products of material exchange, such as lactic acid produced by high-intensity muscle load or fusel oil that causes severe discomfort, headaches and migraines after drinking a lot of alcohol, especially trace amounts of methanol, can be cleared faster, allowing blood vessels in the body to relax state; this transport process can relax the poisoned body tissues in the body, and relaxation will promote blood circulation so that toxic substances can be removed faster and the body can recover faster. This second further active ingredient therefore has an auxiliary effect in the treatment of symptoms of excessive physical fatigue caused by intense physical stress or abuse of alcohol and drugs.

The treatment method used in the present invention is based on a branch of medicine called "psychophysiology". Psychophysiology mainly refers to the science of using psychology, physiology and biology to explore the interaction between psychology and physiology and their effects. The psychological state is an objective parameter of the patient's body, and vice versa, the physiological state is also an objective parameter of the psychology; however, the psychological effect can only be "measured" through a questionnaire survey of the patient, that is, the patient's subjective state of feeling, while the physiological state can be judged through various objective measurement data; among them, the patient's subjective feelings have not yet been described by objective parameters.

The effects of two injection solutions (isotonic saline solutions) were investigated prospectively, namely, an injection solution containing the first other active ingredient combination and an injection solution containing the second other active ingredient combination; wherein the amount of the first other active ingredient combination or the second other active ingredient combination is obtained by multiplying its concentration by the dose of the injection solution, and is injected into the human body via intravenous injection at a rate of 3 drops per second and 250ml per drop, and the administration time is about 30 minutes.

To this end, the treated patients were asked to fill out the WHO questionnaire WHOQOL-BREF to investigate their subjective feelings. The patients were asked to fill out the questionnaire before the first intravenous injection of medication after the treatment process began, and then the patients were given intravenous injections once a week for the next four weeks. After the treatment process, the patients' subjective feelings were investigated again through the questionnaire. The questions of the WHO questionnaire WHOQOL-BREF (a total of 15 questions) involve quality of life and general health, the latter of which is divided into physical health and mental health.

The survey was divided into two groups: the first group included 637 participants, who were treated with an injection solution containing the first other active ingredient combination; among the 637 participants, there were 169 females and 468 males, with an average age of 47 years old (the youngest was 45 years old and the oldest was 71 years old). The second group included 829 participants, who were treated with an injection solution containing the second other active ingredient combination; among the 829 participants, there were 400 females and 429 males, with an average age of 30 years old (the youngest was 21 years old and the oldest was 51 years old). The questionnaire survey results before and after treatment are shown in Figures 1 to 34, which clearly show an improvement in the perception of their own quality of life.

The above embodiments are only for illustrating the principle and effect of the present invention, and are not intended to limit the present invention; therefore, those familiar with this technology may modify and change the above embodiments without departing from the spirit of the present invention. The present invention has industrial applicability, novelty and advancement, and meets the patent requirements, so an application is filed in accordance with the law.

Claims (2)

An ingredient composition for treating stress, psychological trauma or physical fatigue, which is in an isotonic saline solution and contains: 10-20 μmol/L methylcobalamin, 20-30 μmol/L adenosylcobalamin, 5-8mmol/L nicotinic acid amide, 700-1200μmol/L pyridoxine, 150-250μmol/L riboflavin-5-sodium phosphate, 70-150μmol/L thiamine hydrochloride, 1-2mmol/L magnesium chloride, 1-2μmol/L calcium chloride and 2-3mmol/L potassium chloride; 4-8mmol/L phenylalanine, 5-10mmol/L N-acetyl-L-tyrosine, 30-50mmol/L L-argin Amino acid, 20-40mmol/L taurine, 30-70mmol/L glycine, 10-30mmol/L L-carnitine, 2-5mmol/L L-carnosine and 30-50mmol/L L-lysine; among which, these Osmotic saline solution refers to an isotonic saline solution with a concentration of 0.9%; the pH value of this component composition is between 6.5-7.5, and sodium hydroxide and hydrochloric acid are used to adjust the pH value; this component composition It is a drug that can be used to treat stress disorders such as exertion syndrome, difficulty concentrating, exhaustion, and chronic fatigue syndrome, and drugs that can be used to treat physical fatigue symptoms caused by alcohol or drug abuse. Or medications that cause symptoms of excessive physical fatigue from strenuous exercise or muscle training. A composition for treating stress, psychological trauma or physical fatigue, comprising: 10-20 μmol/L methylcobalamin, 20-30 μmol/L adenosylcobalamin, 5-8 mmol/L niacinamide, 700-1200 μmol/L pyridoxine, 150-250 μmol/L riboflavin-5-phosphodiesterone in an isotonic saline solution. sodium iodide, 70-150μmol/L thiamine hydrochloride, 1-2mmol/L magnesium chloride, 1-2μmol/L calcium chloride and 2-3mmol/L potassium chloride; 10-30mmol/L L-isoleucine, 20-40mmol/L L-leucine, 10-30mmol/L L-lysine hydrochloride, 5-15mmol/L L-methionine, 10-25mmol/L L-phenylalanine, 10-25mmol/L L-taurine, 10-30mmol/L L-threonine, 2-5mmol/L L-tryptophan and 20-40mmol/L L-valine; wherein the osmotic pressure saline solution refers to an isotonic pressure saline solution with a concentration of 0.9%; the composition of the composition The pH value is between 6.5-7.5, and sodium hydroxide and hydrochloric acid are used to adjust the pH value; the composition of ingredients can be used for the treatment of fatigue syndrome, attention deficit hyperactivity disorder, fatigue and chronic fatigue syndrome, drugs for excessive fatigue symptoms caused by alcohol or drug abuse, or drugs for excessive fatigue symptoms caused by strenuous exercise or muscle training.

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