TWI797477B - System and method of intelligent prescription for traditional chinese medicine - Google Patents

Abstract

The present invention provides a method for intelligent prescription of traditional Chinese medicine, comprising the following steps: providing a database for storing and providing a plurality of traditional Chinese medicine compound prescriptions and single prescription compositions, including the composition of medicines and the original dosage of medicines; a server providing system services, and the Database connection, wherein the server served by the system includes a prescription input module and a data processing module; input prescription D through the prescription input module, including N prescriptions, wherein the N prescriptions include one or more X compound prescriptions and Z single prescription; and receive and store the prescription D through the data processing module, compare, analyze and screen the prescription D with the drug composition and the original dosage of the drug in the database, so as to simplify the prescription D's processing, thereby obtaining simplified prescription G. On the other hand, the present invention provides a prescription system using the intelligent prescription of traditional Chinese medicine. Through the invention, it is possible to simplify the doctor's prescribing of medicines, conversion of original doses and monitoring of whether the doses of medicines are safe.

Description

A system and method for intelligent prescription of traditional Chinese medicine

The invention relates to a traditional Chinese medicine prescription system and method, which can simplify doctors' prescribing of drug compound prescriptions, conversion of original doses, and monitoring of whether the doses of drugs are safe.

Modern Chinese medicine is divided into two categories: Chinese herbal decoction pieces (decoction) and traditional Chinese medicine granules (also known as traditional Chinese medicine granules, traditional Chinese medicine concentrated granules or traditional Chinese medicine formula granules, etc.). It is inconvenient and demanding to cook, and it is difficult for ordinary patients to master the decoction skills. Therefore, another concentrated scientific Chinese medicine has been developed. The agency selects and announces the prescriptions with curative effects, manufactures them according to the quality control standards of traditional Chinese medicine preparations, and the products pass the inspection, and the licenses of Chinese medicine preparations are issued according to law. Concentrated scientific Chinese medicine retains the efficacy of traditional Chinese medicine. When taken, it is easily absorbed by the human body and can quickly exert its curative effect. Compared with the efficacy of traditional traditional decoctions, the medicine has a fixed concentration ratio, uniform preparation, and precise dosage.

The preparation method of traditional Chinese medicine granules, the first step is to decoct Chinese medicinal materials such as the traditional way of decocting in water, extract them into a liquid medicine, and then slowly heat to evaporate the water to become an extract, and then add an excipient (usually starch), After the spray granulation process, different dosage forms such as powder, pill, ointment, granule, capsule and lozenge are prepared. The ingredients contained in concentrated Chinese medicine preparations are not as simple as Western medicine. This is because the sources of Chinese medicinal materials used by each Chinese medicine manufacturer are inconsistent, and the manufacturing process and quality testing specifications of the medicines are all different. Each pharmaceutical factory formulates its own specifications, so the concentrated Chinese medicine granules produced are not exactly the same. Based on the traditional Chinese medicine license issued by the Department of Traditional Chinese Medicine of the Ministry of Health and Welfare, the mint concentrated granules from different manufacturers were compared and analyzed (Table 1). Based on the data of manufacturer A, during the preparation process, the mint is first boiled into a liquid medicine and then made into an extract. Each 0.5g of the extract is equivalent to 3g of mint raw materials, and then 0.5g of mint is added to each 0.5g of the extract starch to carry out spray granulation, therefore, the final peppermint concentrated granules contain 3.0g of peppermint raw material in every 1.0g. According to the different production processes of different manufacturers, the concentration ratio is also different, thus increasing the difficulty of actual dosage conversion.

Table 1. Ingredients of peppermint concentrate granules from various manufacturers

In the traditional Chinese medicine license issued by the Department of Traditional Chinese Medicine of the Ministry of Health and Welfare, mint ingredients are also included in the compound formula of various concentrated traditional Chinese medicine granules, such as: Xigan Mingmu Powder Granules, Qingshang Fangfeng Tang Concentrated Powder, Xiaoyao Powder Concentrated Powder, Cang Ersan Concentrated Granules, Yinqiaosan Concentrated Fine Granules and other compound formulations, therefore, it is even more difficult to accurately calculate repeated doses for a single component. In addition, the actual ingredients of the compound will vary due to the properties of different manufacturers and products. For example, Shiquan Dabu Decoction is indicated for Qi and blood deficiency, limb fatigue, and its efficacy is to nourish blood and Qi. According to the comparative analysis of the prescription content provided by different manufacturers, two types of prescription content can be obtained (Table 2).

Table 2. Composition of Shiquan Dabu Decoction from different manufacturers

The toxicity of traditional Chinese medicine generally refers to the partiality of drugs in a broad sense, and refers to the damage of drugs to the body in a narrow sense. Toxic reactions are different from side effects. It is more harmful to the human body and even life-threatening. "Shen Nong's Materia Medica" divides traditional Chinese medicine into three grades according to the toxicity of the medicinal materials. At that time, it was considered that the non-toxic "top grade" medicinal materials were "jun" medicines, the "middle grade" medicinal materials with less toxicity were "chen" medicines, and the more toxic "low grade" medicinal materials "The medicinal materials are "assistant" medicines. The "Compendium of Materia Medica" of the Ming Dynasty divided the toxicity of drugs into "big poisonous", "poisonous", "slightly poisonous", "slightly poisonous" and "non-toxic", such as: pokeweed, asarum, bitter almond, Polygonum multiflorum, aconite, etc. There are reports of adverse reactions, but relatively less toxic or non-toxic Chinese medicines do not absolutely cause toxic reactions, such as: ginseng, Artemisia argyi, Anemarrhena, etc. have all been reported to have toxic reactions, which is related to excessive doses or taking too long are closely related. At present, the common clinical adverse reactions of traditional Chinese medicine include nephropathy caused by aristolochic acid, arrhythmia caused by aconitine, myocardial damage and blood circulation and blood stasis The interaction between anticoagulants of related Chinese medicines and western medicines (such as: the blood-activating and stasis-removing medicine Dan commonly used in traditional Chinese medicine participates in the anticoagulant drug Warfarin); in addition, the main component of the Chinese medicine Ephedra is ephedrine, which can excite the myocardium and increase blood pressure. Cardiac output, if used together with bronchodilators such as theophylline, may aggravate the side effects of palpitations.

Due to the learning background of Chinese medicine practitioners, they mainly use the dosage before the concentration of the medicine, but because the dosage forms of the medicines that are often prescribed today are compound prescriptions, this makes Chinese medicine doctors often not know the original dosage in clinical practice, and have no time to check and evaluate the curative effect. Also unstable. When a Chinese physician's prescription contains multiple compound prescriptions, repeated medications are likely to occur, resulting in waste of dispensing time and drug costs, as well as concerns about medication safety.

The present invention is based on the prescription ingredients and actual dosage of a traditional Chinese medicine granule preparation to establish a drug composition and dosage database, wherein the database of the Department of Traditional Chinese Medicine of the Ministry of Health and Welfare of the Republic of China is used as an example of the present invention, which is only a preferred example of the present invention. Examples, but not limiting the scope of the present invention.

First, a total of 22,565 records of complete Chinese medicine licenses were downloaded from the website of the Department of Traditional Chinese Medicine of the Ministry of Health and Welfare, and a total of 6,802 records of concentrated granules and concentrated fine granules were screened out, including 4,519 records of compound prescriptions and 2,283 records of single prescriptions. Then, extract the Chinese drug name and English drug name from the drug name column, and then extract all the crude drug names and their pre-concentrated doses from the prescription ingredient column, excluding a total of 31 excipients that have no curative effect, and then standardize the crude drug names in sequence. 812 kinds, text descriptions of crude drugs made into extracts, dosage units, dosage per gram of crude drugs before concentration, drug names, and finally the total doses of crude drugs and excipients, and related data are concatenated into a relational database.

Use the drug composition and dosage database to solve the following solutions through the system and method of the present invention: 1. Instantly convert the dosage of each medicinal material in the concentrated granule and the concentrated fine granule before concentration, Let the doctor know the original dose of the drug and correctly predict the curative effect; 2. Instantly compare the multiple compound prescriptions and single medicines in the doctor's single prescription with all the compound prescriptions in the database to find the most streamlined combination, so that The working hours of the pharmacist are shortened, and the powder flying loss of the concentrated granules is reduced during the dispensing. 3. The system can customize the list of TCM warehouses of different TCM medical institutions according to the serial number codes of the licenses of each drug, and will not face the problem that the same drug has different brands.

According to the present invention, the drug composition and dosage database of the traditional Chinese medicine granules contains the license number, Chinese product name, English product name, dosage form, prescription ingredients, and brand name of the Chinese medicine granules, wherein the prescription ingredients include the content and quantity of each ingredient. , unit, ratio of crude drug to extract and dosage of other additives.

F_f，f>1，藉由上述流程以得到一精簡處方G：G₁+G₂+…G_f(複方)，N>f。 Therefore, the present invention provides an intelligent prescription system for traditional Chinese medicine, including: a database for storing and providing multiple Chinese medicine compound prescriptions and single prescriptions, including their drug composition and the original dosage of medication; and a system service server, and The database connection, wherein the system service server includes: a prescription input module, used to input a D prescription, including N prescriptions, wherein the N prescriptions include one or more X compound prescriptions and Z single prescriptions, one The data processing module is used to receive and store the D prescription, compare, analyze and screen the D prescription with the drug composition and the original dosage of the drug in the database, so as to simplify the processing of the D prescription, so as to obtain a streamlined Prescription G, this process includes: providing D prescriptions containing N prescriptions, expressed as: D prescription = E ₁ + E ₂ + ... E _N , where E ₁ , E ₂ ... E _N are different prescriptions, the N prescriptions Contains X compound prescriptions and Z single prescriptions, wherein the Z single prescriptions are composed of none or one or more single herbal medicines, and the D prescription contains the X compound prescriptions and Z single prescriptions that do not repeat n flavors. Herbal medicines, among the single medicines with non-repetitive n flavors, G ₁ compound formula consisting of at most F ₁ single medicines can be used, and the most available F _f flavors can be found from the remaining (nF _f - ₁ ) single medicines G _f compound composed of single herbal medicines and least redundant single herbal medicines, where n

F _f , f>1, obtain a simplified prescription G through the above process: G ₁ +G ₂ +...G _f (compound), N>f.

The TCM intelligent prescription system of the present invention further includes an output device for outputting the input prescription and the simplified prescription. In a specific embodiment, the output device is a display or a display screen.

The database used in the intelligent prescription system of traditional Chinese medicine of the present invention, wherein the composition of their medicines and the original dosage of the medicines are from the content of the prescription ingredients marked on the Chinese medicine license.

The TCM intelligent prescription system of the present invention further includes a compound prescription simplification selection module, which is used to select the simplification prescription G according to the following process to obtain a simplification selection prescription: if there are compound prescriptions with the same composition quantity as the number of redundant single herbs, a total of H ₁ , and there are H ₁ remaining single herb compositions, use these H ₁ remaining single herb compositions to find out the compound formula that can be composed of the most single herbal medicines and the least redundant single herbal medicines, if Occur that the composition quantity is the same as the excess single herbal medicine quantity, then process according to the previous process, the composition quantity and the excess single herbal medicine quantity are the same for one time, at last from the H ₁ * H ₂ *...* H _I kinds of prescriptions, Pick out a total of h types of prescriptions with the fewest compound prescriptions.

In a specific embodiment, the prescription of the h least number of compound prescriptions will be presented on the system to prompt the doctor, if the doctor chooses any one of the h kinds of least number of compound prescriptions, then this prescription will replace the D prescription.

In the TCM intelligent prescription system of the present invention, the actual dosage of the traditional Chinese herbal medicine corresponding to the compound prescription before concentration is converted into the original dosage of the single herb, which will be displayed on the output device.

In a specific embodiment, after the original dosage of the single medicine is compared by the system, if it exceeds the safe dosage of the medicine in the database, the system will prompt. Specifically, the safe dosage of drugs in the database refers to the safe dosage of a single drug extracted from the usage and dosage of all medicinal materials in the Pharmacopoeia.

In a specific embodiment, the composition of each single drug corresponding to the compound formula and the actual dose before concentration are presented in a bar graph or a block graph.

F_f，f>1，藉此，得到一精簡處方G：G₁+G₂+…G_f(複方)，N>f。 The present invention also provides a method for intelligent prescription of traditional Chinese medicine, which includes the following steps: providing a database for storing and providing multiple Chinese medicine compound prescriptions and single prescription compositions, including their drug composition and the original dosage of medication; providing a system service server The server is connected to the database, wherein the system service server includes a prescription input module and a data processing module; a D prescription is input through the prescription input module, including N prescriptions, wherein the N prescriptions Including one or more X compound prescriptions and Z single prescriptions; and receiving and storing the D prescription through the data processing module, comparing, analyzing and screening the D prescription with the drug composition and the original dosage of the drug in the database, so as to Perform the process of simplifying the D prescription to obtain a simplified prescription G. This process includes: providing a D prescription containing N prescriptions, expressed as: D prescription=E ₁ +E ₂ +...E _N , where E ₁ , E ₂ …E _N. are different prescriptions, the N prescriptions include X compound prescriptions and Z single prescriptions, wherein the Z single prescriptions are composed of nothing or one or more single herbs, and the D prescriptions contain the X compound prescriptions As well as the non-repetitive n flavors of single medicines in the Z single prescription, among the single medicines with non-repetitive n flavors, G ₁ compound prescription composed of at most F ₁ single medicines can be used, from the remaining (nF _f-1 ) flavors Among the single medicines, find the G _f compound that can be composed of the most F _f single medicines and the least redundant single medicines, where n

F _f , f>1, thereby obtaining a simplified prescription G: G ₁ +G ₂ +...G _f (compound), N>f.

The intelligent prescription method for traditional Chinese medicine of the present invention further includes a compound prescription simplification selection step, which step selects the simplification prescription G according to the following process to obtain a simplification selection prescription: if there are H ₁ kinds of compound prescriptions with the same composition quantity as the number of redundant single herbs , and there are H ₁ kinds of remaining single herbal medicines, use these H ₁ remaining single herbal medicines to find out the compound formula that can be composed of the most single herbal medicines and the least redundant single herbal medicines, if it appears again The composition quantity is the same as the excess single herbal medicine quantity, then process according to the previous step, the composition quantity and the surplus single herb quantity are the same for one time, finally from the H ₁ * H ₂ *... * H _I kinds of prescriptions, choose There are a total of h kinds of prescriptions with the least number of compound prescriptions.

In a specific embodiment, the prescription of the h least number of compound prescriptions will be presented on the system to prompt the doctor, if the doctor chooses any one of the h kinds of least number of compound prescriptions, then this prescription will replace the D prescription.

The method of intelligent prescription of traditional Chinese medicine of the present invention can provide an output device additionally, in order to output The input prescription and the condensed prescription.

In the TCM intelligent prescription method of the present invention, the actual dosage of the traditional Chinese medicinal materials corresponding to the compound prescription before concentration is converted into the original dosage of the single herb, which will be displayed on the output device.

In a specific embodiment, after the original dosage of the single medicine is compared by the system, if it exceeds the safe dosage of the medicine in the database, the system will prompt. Specifically, the safe dosage of drugs in the database refers to the safe dosage of a single drug extracted from the usage and dosage of all medicinal materials in the Pharmacopoeia.

In a specific embodiment, the composition of each single drug corresponding to the compound formula and the actual dose before concentration are presented in a bar graph or a block graph.

10: An intelligent prescription system for traditional Chinese medicine

20: Database

30: System service server

40: Prescription input module

50: Data processing module

60: Display device

Figure 1. The block diagram of the TCM intelligent prescription system.

Figure 2. Schematic diagram of the visual presentation of the TCM intelligent prescription system.

Figure 3. Schematic diagram of the relationship between drugs and compound prescriptions. Clicking one of the single medicines (A, dotted square) in the prescription will display all the compound prescriptions (B, dotted square) containing the single medicine on the compound similarity ranking panel.

Figure 4. Schematic diagram of the composition of the compound drug and the remaining drugs. Click any compound (A, dotted line square) in the compound similarity ranking panel, and B will display the corresponding used medicine on the total weight of medicinal materials panel, in which the bar chart above the dotted line box and the box chart below are highlighted. Herbs used are shown as faded to unused remnants. C: In the real dose bar chart panel, the drugs used are highlighted, and the drugs that are displayed as diluted are redundant traditional Chinese medicines for this compound.

Figure 5 shows an operation panel for dose conversion based on "Shiquan Dabu Decoction 1g, mint 1g".

Fig. 6, including Fig. 6a and Fig. 6b, shows the operation panel for simplification of prescriptions with 21 kinds of medicine originally prescribed in a case.

Figure 7 shows the composition of simplified prescriptions G1 and G2 in the compound ranking list. A is Tianwangbuxindan Compound (G1), which is composed of 18 single herbs with simplified prescriptions in the list of compound prescriptions; B is Bupleurum Plus Longgu Oyster Decoction Compound (G2), which is composed of 11 single herbs with simplified prescriptions in the list of prescriptions .

Figure 8 shows a schematic diagram of the simplified prescription G3 composition and remaining medicines in the compound prescription list. A is the compound combination of 4 single herbs in simplified prescriptions in the list of compound prescriptions; B is the remaining drug composition of the selected Sanzhong Kuijian Decoction compound; C is the remaining drug composition of the selected Qingshu Yiqi Decoction compound.

Figure 9 shows a schematic diagram of the simplified prescription G4 composition and remaining medicines in the compound prescription list. A is the compound combination of three single herbs in the list of simplified prescriptions; B is the remaining drug composition of the selected Gexia Zhuyu Decoction compound; C is the remaining drug composition of the selected Guizhi Fuling Pills compound; D is the selected Xuefu Zhuyu Decoction The composition of the remaining medicine of the soup compound; E is the composition of the remaining medicine of the selected Shaofu Zhuyu Decoction.

Figure 10 shows a schematic diagram of the simplified prescription G5 composition and remaining medicines in the compound prescription list. A is the compound combination of 2 single-flavored medicines in the list of simplified prescriptions; B is the composition of the remaining medicines selected from the compound prescription of Bixie Fenqing Decoction; C is the composition of the remaining medicines from the compound prescription of Sangliu San; D is the compound prescription of Xuanshaofu Zhuyu Decoction The rest of the drug composition.

Figure 11 shows the simplified prescription G6 composition and the final remaining single prescription in the compound prescription list. A is the Shaofu Zhuyu Decoction Compound (G6); B is the final remaining single prescription with a total of 8 flavors.

Figure 12 shows the time spent by the pharmacist in dispensing the number of medicinal materials in a single prescription.

The practical application range of the present invention can be further proved by the following specific examples, which are only preferred embodiments of the present invention and do not limit the scope of the present invention. Therefore, any simple changes and modifications made according to the scope of the present invention and the content of the description of the present invention are still covered by this scope of invention covered.

Embodiment 1. Description of the Intelligent Prescription System of Traditional Chinese Medicine

F_f，f>1，藉由上述流程以得到一精簡處方G：G₁+G₂+…G_f(複方)，N>f。輸出該精簡處方於一輸出裝置60(如顯示器或顯示螢幕)。 As shown in Figure 1, the present invention provides a kind of traditional Chinese medicine intelligent prescription system 10, comprising: a database 20, in order to store and provide multiple Chinese medicine compound prescriptions and single prescriptions, including the original doses of their drug composition and medication; and a system The service server 30 is connected to the database 20, wherein the system service server 30 includes: a prescription input module 40, used to input a D prescription, including N prescriptions, wherein the N prescriptions include one or more X compound prescription and Z single prescription, output the input prescription on an output device 60 (such as a display or screen), and a data processing module 50 for receiving and storing the D prescription, and the D prescription and the medicine in the database The composition and the original dose of medication are compared, analyzed and screened to simplify the D prescription to obtain a simplified prescription G. This processing includes: providing D prescriptions containing N prescriptions, expressed as: D prescription = E ₁ +E ₂ +...E _N , where E ₁ , E ₂ ...E _N . are different prescriptions, and the N prescriptions include X compound prescriptions and Z single prescriptions, wherein the Z single prescriptions are none or one or more single prescriptions The D prescription contains the X compound prescription and the n-unrepeated single-herb medicine in the Z-pen single prescription. Of the n-unrepeated single-herb medicines, at most F ₁ single-herb medicines can be used. G ₁ compound, from the remaining (nF _f-1 ) single herbs, find the G _f compound that can be composed of the most F _f single herbs and the least redundant single herbs, where n

F _f , f>1, obtain a simplified prescription G through the above process: G ₁ +G ₂ +...G _f (compound), N>f. Output the condensed prescription to an output device 60 (such as a display or display screen).

Basic introduction: As shown in Figure 2, the TCM intelligent prescription system of the present invention includes five parts in a visual presentation: first, prescription selection and dosage input; second, drug composition and real dosage before concentration (bar graph); Third, drug composition and real dose before concentration (block diagram); fourth, compound similarity ranking; and fifth, real dose bar chart. As shown in Figure 2: Block A is for prescription selection and dosage input, which includes the prescription input field and the dosage input field, when the display "prescription Fill in the prescription to be used in the input box of "Name_Drug Name 1", and fill in the dosage (g) of the drug name 1 in the input box showing "Prescription Name_Drug Name 1/g". Box B, the bar graph of prescription selection and dose input, where the Y axis represents the composition of all compound prescriptions and single herbs in the prescription, and the X axis represents the actual dose of each Chinese medicine before concentration. When the mouse moves to a certain drug , the actual dose of the drug before concentration will be shown. Block C, the block diagram of the composition of the drug and the actual dose before concentration. The larger the dose of the drug, the larger the area of the block. For example, the largest doses are Pinellia and Bupleuri, both of which are 1.6g. Square D, compound similar ranking, is to find out the compound that can be composed of the most medicinal ingredients based on the composition of all the compound prescriptions and single herbs in the original prescription, and arrange them in descending order according to the number of ingredients. The drug composition in each compound, this drug composition is derived from the original prescription, the additional drug in the compound will not be displayed. Box E: bar graph of actual dose, the name of the compound appearing in the compound similarity ranking, the drug composition of the compound (Y axis) and the actual dose of each drug composition (X axis).

The advanced functions include the association between medicines and compound prescriptions, the composition of compound medicines and remaining medicines. The original prescriptions in Figure 3 and Figure 4 are 2 grams of Qingxin Lianziyin, 2 grams of Bazheng Powder, 1 gram of Yiguanjian, 1 gram of Xiaojianzhong Decoction, and 2 grams of Dachaihu Decoction. Click one of the single medicines (box A) in the prescription on the right side of Figure 3, and all the compound prescriptions containing the single medicine will appear on the compound similarity ranking panel (box B). Click on one of the compound recipes (Shengyang Yiwei Decoction) in box A on the similar ranking panel of the compound recipe shown on the left side of Figure 4, and the corresponding drug used in the total weight of the medicinal materials is highlighted in the box B of Figure 4 (bar graph) The text part of the panel is highlighted on the bar chart. The box image below is highlighted on the box, and the medicinal materials that are displayed as faded are all unused medicines. Figure 4C will also highlight the drugs used on the real dose bar chart panel, and the faded bar chart is the redundant traditional Chinese medicine for this compound. When streamlining the prescription, the system will sum up the number of prescribed medicines and the number of new and old medicines, and choose the combination with the least total as the best simplified prescription.

Embodiment two, dose conversion

The dosage conversion formula of traditional Chinese medicine granules before concentration of medicinal materials:

According to the labeling content of the prescription ingredients of the traditional Chinese medicine license of traditional Chinese medicine granules (compound for short), it can be known that when a prescription contains n single herbs, the types of the n single herbs are A ₁ , A ₂ , ..., A _n ; and the doses of the n single medicines correspond to B ₁ , B ₂ , ..., B _n (grams); then the compound contains A ₁ *B ₁ +A ₂ *B ₂ +...+ per C gram A _n *B _n ; therefore, it is further calculated that the formula contains A ₁ *B ₁ /C+A ₂ *B ₂ /C+...+A _n *B _n /C per 1 gram. According to the above formula conversion, when the name and dosage of the compound prescription are input, the actual dosage of the traditional Chinese medicinal materials corresponding to the compound prescription before concentration will be displayed in the system in real time.

Concentrated granules (hereinafter referred to as “compound formula”) are the conversion formulas for pre-concentrated doses of medicinal materials:

In the traditional Chinese medicine license of a certain compound, the prescription ingredients contain n single herbs

Types of single herbs = A ₁ , A ₂ ,..., A _n

Dosage of each single drug = B ₁ , B ₂ ,..., B _n (grams)

Every C grams of a certain compound contains: A ₁ * B ₁ + A ₂ * B ₂ +…+ A _n * B _n

Each gram of a certain compound contains: A ₁ * B ₁ / C + A ₂ * B ₂ / C + ... + A _n * B _n / C The conversion result will be displayed immediately after the doctor inputs the dose.

Example: Take a prescription as "Shiquan Dabu Decoction 1g, Peppermint 1g" to convert the concentrated granules of traditional Chinese medicine in the prescription and the actual dose of traditional Chinese medicinal materials before concentration. The Shiquan Dabu Decoction is the concentrated granule of "Hong Kong Xianglan" Shiquan Dabu Decoction No. 017057 of the Ministry of Health. Each 9 grams contains 3 grams of Poria cocos, 3 grams of Atractylodes macrocephala, 3 grams of ginseng, 3 grams of rehmannia glutinosa, 3 grams of peony, 3 grams of roasted licorice, 3 grams of astragalus, 3 grams of cinnamon, 3 grams of angelica, 3 grams of Chuanxiong, 3 grams of ginger, and 2 grams of jujube. The mint is the concentrated fine grain of "Hong Kong Honglan" mint, No. 037903, No. 037903 of the Ministry of Health, and every 1.2 grams contains Mint 3.2 grams. First, input the first Chinese medicine granule (Shiquan Dabu Decoction) and the dose (1g) of the first Chinese medicine granule in the prescription selection and dose input column; then input the second Chinese medicine granule (mint) and the first Chinese medicine granule 2. The dosage (1g) of traditional Chinese medicine granules (as shown in the dotted square in Figure 5), after the input is completed, follow the drug license of "Shiquan Dabu Tang Chinese Medicine Granules" and "Mint Traditional Chinese Medicine Granules" in the pre-established database The system converts the drug composition and concentration ratio on the certificate, and visually presents the converted dose of each single drug in the prescription before concentration (Figure 5, left column). Therefore, it can be seen from Fig. 5 that 1 g of mint traditional Chinese medicine granules in the prescription is actually made of 2.667 g of traditional mint traditional Chinese medicinal materials after conversion.

Traditional Chinese medicine practitioners often prescribe traditional Chinese medicine granules, while traditional Chinese medicinal materials (fen, qian, liang) are mostly presented in traditional Chinese medicine classics and courses of Chinese medicine departments. In the past, limited by the complicated dosage conversion and TCM items, it was difficult for TCM physicians to perform dosage analysis efficiently. Through the real-time dose conversion of the present invention, doctors can know the real dose of the prescription, so that the prescription can be prescribed accurately and the curative effect can be improved. The advantage of this system is that it can link academic knowledge with clinical operations, assist physicians in identifying the real dosage of drugs, make prescriptions more accurate, and improve efficacy. Another advantage is the control of poisonous traditional Chinese medicine. Dose conversion can also assist doctors in controlling the total dose of a certain medicine in the prescription, which is suitable for the management of toxic and highly toxic medicines.

Embodiment three, streamlining the prescription

F_f， f>1；根據上述方法可得到一精簡處方G：G₁+G₂+…G_f(複方)，N>f。 A D prescription contains N prescriptions, where the N prescriptions include X compound prescriptions and Z single prescriptions, where the Z single prescriptions can be none or one or more single ingredients, expressed as D prescription = E ₁ + E ₂ +...E _N , wherein E ₁ , E ₂ ...E _N . are different prescriptions, wherein the D prescription contains the X compound prescription and the single medicine with n flavors not repeated in the Z single prescription, and the n flavors are not repeated Among the single herbal medicines, the G ₁ compound composed of the most F ₁ single herbal medicines can be used, and from the remaining (nF _f-1 ) single herbal medicines, find out which can be composed of the most F _f single herbal medicines and the least redundant single herbal medicines The G _f compound of flavor medicine, wherein n

F _f , f>1; according to the above method, a simplified prescription G can be obtained: G ₁ +G ₂ +...G _f (compound), N>f.

If there are H ₁ kinds of compound prescriptions with the same number of compositions, there are also H ₁ kinds of remaining single herb compositions, then use these H ₁ remaining single herb compositions to find out the most usable single herb composition and The compound recipe with the least redundant single herbs. If the number of components is the same again, proceed according to the previous step, and the number of components is the same for a total of I times; finally, from the H ₁ , H ₂ , _. . . These h types of prescriptions will be displayed on the system to prompt the physician to recommend that the physician simplify the prescription; if the physician chooses any of these prescriptions, the prescription will replace the D prescription. If the doctor does not want to simplify, just ignore the prompt.

Streamlined Prescribing Formulas

A doctor writes D prescriptions containing N prescriptions, where the N prescriptions include X compound prescriptions and Z single prescriptions (wherein the Z single prescriptions can be nothing or composed of one or more single medicines)

D Prescription=E ₁ +E ₂ +…E _N , E1, E2…E _N . They are different prescriptions

D The prescription contains a single drug with n different flavors

Simplified steps:

A. From the n single herbs, find the G ₁ compound that can be composed of at most F ₁ single herbs.

F _f ，f>1。 B. From the remaining ( n - F _{f -1} ) single herbal medicines, find out the G _f compound that can be composed of the most F _f single herbal medicines and the least redundant single herbal medicines, n

F _f , f >1.

C. A simplified prescription = G ₁ + G ₂ +…+ G _f (compound), N > f . If there are H ₁ kinds of compound prescriptions with the same composition number as the number of redundant single herbs, then there are also H ₁ kinds of remaining single herbs, then use these H ₁ remaining single herbs to find out the most available A compound that consists of a single herbal medicine with the least excess single herbal medicine.

D. If the quantity of components is the same as the quantity of redundant single herbs again, proceed according to the previous step. Occur that the composition quantity is the same as the redundant single herb quantity for 1 time.

E. Finally, from the H ₁ * H ₂ *...* H _I types of prescriptions, pick out a total of h types of prescriptions with the fewest number of compound prescriptions.

1. This type of prescription will be displayed on the system to prompt the physician, suggesting that the physician simplify the prescription.

G. If the doctor chooses one of the prescriptions, this prescription will replace the D prescription.

Xin. If the doctor does not want to simplify, just ignore the prompt.

Take the 21 kinds of prescriptions issued by one of the original prescriptions of a case as an example, in which the drugs in the drug list prescribed by the original prescription include the compound prescription: Tianwang Buxin Dan (Wei Department Pharmaceutical Zi No. 014990 "Hong Kong Honglan" Tianwang Buxindan Concentrated Granules, Containing Rehmannia glutinosa, Ginseng, Poria, Polygala, Shichangpu, Scrophulariaceae, Baiziren, Campanulaceae, Asparagus, Salvia, Suanzaoren, Licorice, Ophiopogon japonicus, Baibu, Eucommia, Fushen, Schisandra , Danggui), Bupleurum plus Longgu Oyster Soup (Shuntian, No. 037761 "Shuntian" Bupleurum plus Longgu Oyster Soup Concentrated Granules, containing Bupleurum, Longgu, Ginger, Ginseng, Poria, Scutellaria, Oyster, Guizhi , pinellia, jujube, rhubarb) and unilateral: Asarum, Alisma, Eclipta, black medicine, fennel, Trichosanthes kernel, Shichangpu, Puhuang, Sangji, red peony, Bupleurum, Guizhi , light bamboo leaves, peach kernels, cork, tortoise shell, wolfberry, kudzu root, cohosh. The original prescription is simplified through the present invention.

First, enter the 21 prescriptions from the original prescription into the prescription selection and dose input column (Figure 6a, block A). After the input is completed, the original prescription contains 43 unique single ingredients among the 21 prescriptions. medicine, wherein the 43 non-repetitive single herbal medicines present a bar graph of the total weight of medicinal materials (Fig. 6a, square B and Fig. 6b, square F) and a block diagram (Fig. 6a, square C). The real dosage of the single herbal medicines before concentration, wherein Fig. 6a, box B shows some of the 43 non-repetitive single herbal medicines (single herbal medicines with a dosage of more than 1g), and Fig. 6b, box F shows all The 43 unique single medicines, in which, in Figure 6b, the left side of square F shows single medicines with a dosage of more than 1g, and in Figure 6b, the right side of square F shows single medicines with a dosage of less than 1g. Other In addition, the system simultaneously presents the ranking list of compound prescriptions of the 43 single herbs, and finds out the compound formula that can be composed of the most herbs, and arranges them in descending order according to the number of ingredients (Figure 6a, box D). Clicking on any compound recipe on the list of compound recipe similarities will further display the real dosage of each ingredient of each prescription before concentration (Figure 6a, box E). According to the simplification steps of the present invention, the actual prescription simplification is carried out:

According to the streamlined step A method: from the n single herbs, find the G ₁ compound that can be composed of the most F ₁ single herbs. According to this method, the only Tianwangbuxindan compound formula that can be composed of up to 18 single herbs can be found out of 43 single herbs. Here, the compound formula of Tianwangbuxindan is G1 (Figure 7, box A). From the remaining 25 single herbs (that is, 43 single herbs - 18 single herbs = the remaining 25 single herbs), find the only Bupleurum plus keel oyster that can be composed of up to 11 single herbs Soup Compound G2 (Figure 7, box B).

According to the simplified step B method, from the remaining ( n - F _{f -1} ) single herbal medicines, find out the G _f that can be composed of the most F _f single herbal medicines and the least redundant single herbal medicines. Therefore, in the next stage, there are 2 kinds of compound prescriptions with the same composition and quantity (including: Sanzhong Kuijian Decoction and Qingshu Yiqi Decoction, which can simplify 4 herbs) (Figure 8, box A). Find the least excess single herb, if you choose Sanzhong Kuijian Decoction, you will need Gentiancao, Coptifolia Root, Anemarrhena, Kelp, Curcuma, Forsythia, Vitex Sanleng, Zhilicorice, Dangguiwei, Coptidis, Radix Paeoniae Alba, total 11 herbs (Figure 8, box B); if you choose Qingshu Yiqi Decoction, there are 7 herbs in total (Figure 8, box C), including Cangzhu, Astragalus, Tangerine Peel, Shenko, Atractylodes Rhizoma Atractylodes Rhizome, Qingpi, and Zhigancao. Therefore, Qingshu Yiqi Decoction Compound G3 was selected.

In the next stage, there are 4 kinds of compound prescriptions with the same composition and quantity (Gexia Zhuyu Decoction, Guizhi Fuling Pills, Xuefu Zhuyu Decoction, Shaofu Zhuyu Decoction, all of which can be reduced to 3 herbs) (Figure 9, box A) , and then find the least excess single herb. If you choose Gexia Zhuyu Decoction, there will be extra safflower, Moutan bark, Wulingzhi, Chuanxiong, Citrus aurantii, Rhizoma Cyperi, and Corydalis Corydalis, a total of 7 herbs (Figure 9, box B); if you choose Guizhi Fuling Pills, there is an extra Moutan bark, a total of 1 herbs (Figure 9, box C); choose Xuefu Zhuyu Decoction , then there are 4 herbs in total (Picture 9, square D) that are redundant, such as safflower, Chuan Achyranthes bidentata, Citrus aurantii, and Chuanxiong; if you choose Shaofu Zhuyu Decoction, you will have redundant Wulingzhi, Corydalis Corydalis, Myrrh, Cinnamon, Chuanxiong, and Dried Ginger , a total of 6 herbs (Fig. 9, block E). Therefore, Guizhi Fuling Pill Compound G4 was selected.

In the next stage, there will be 3 types of compound prescriptions with the same amount of composition (Xiaoxuefenqingyin, Sangxuelu San, and Shaofu Zhuyu Decoction, all of which can be reduced to 2 herbs) (Figure 10, box A), and then find the least redundant single herbs . If you choose the clear drink of mulberry, there will be 3 additional herbs, namely, mulberry, Yizhiren, and licorice shoots (Figure 10, box B); Box C); if you choose Shaofu Zhuyu Decoction, there will be 6 extra medicines including Wulingzhi, Corydalis Corydalis, Myrrha, Cinnamon, Chuanxiong, and Dried Ginger (Figure 10, box D). Therefore, the mulberry and octopus powder compound G5 was selected.

In the next stage, select the only Shaofu Zhuyu Decoction compound recipe G6 that can be composed of at most 2 single herbs (Figure 11, square A), and finally the remaining single recipes have a total of 8 ingredients (Eclipta chinensis, Wuyao, Trichosanthes kernel, Sangjisheng , bupleurum, light bamboo leaves, wolfberry) (Figure 11, box B).

Therefore, the simplification of Step C simplifies the prescriptions as Tianwang Buxin Dan (G1), Bupleurum plus Keel Oyster (G2), Qingshu Yiqi Decoction (G3), Guizhi Fuling Pill (G4), Sangliu Powder (G5), Shaofu Zhuyu Decoction (G6) and 8 flavors of single prescription, including: Eclipta chinensis, Wuyao, Trichosanthes kernel, Sangjisheng, Bupleurum, Danzhuye, Lycium barbarum and Asarum, a total of 14 single compound prescriptions, a total of 7 simplified flavors . Since there is no compound recipe with the same composition quantity as the excess single medicine quantity in step A and step B, steps D, E, B and G are ignored in this streamlined prescription step. According to step xin, if the physician selects one of the prescriptions, this prescription will replace the D prescription. If the doctor does not want to simplify, just ignore the prompt.

If the doctor decides to adopt the simplified prescription, the simplified prescription will replace the original prescription. this At the same time, the real-time dose conversion of the system can remind whether the dose of each prescription is overdose after simplification, and the doctor can adjust to the optimum according to the timely dose conversion. Through the simplification of the present invention, patients can be prevented from taking too much single herb dose. When more overlapping prescriptions appear in a prescription, it is more likely that the dosage of a single TCM item will accumulate. For example, when Xiaoyao Powder, Liujunzi Decoction, and Xuefu Zhuyu Decoction are prescribed in the same prescription, "Glycyrrhizae" becomes the single Chinese medicine with the highest cumulative dose in the entire prescription. Patients may inadvertently allow patients to take doses of traditional Chinese medicines that exceed the doctor's expectations. For example, refer to the safe dosage database: According to the "Taiwan Chinese Pharmacopoeia" compiled by the Taiwan Ministry of Health and Welfare and the "Chinese Pharmacopoeia" compiled by the Chinese National Pharmacopoeia Committee Pharmacopoeia of the People's Republic of China], the present invention extracts the usage and dosage of all medicinal materials and establishes a safe dosage database of Chinese medicinal materials. After the system performs dosage conversion for the prescription prescribed by the doctor, the system will then compare whether the original dosage of these drugs exceeds the usage and dosage recorded in the Pharmacopoeia. If it exceeds, the system will prompt and the doctor will judge whether to modify the dosage. Therefore, the system of the present invention provides a simplified prescription to prevent patients from taking more than the expected dose of traditional Chinese medicine, so as to ensure the safety of medication.

Embodiment 4, cost reduction

Based on the data analysis of the Bureau of Traditional Chinese Medicine of the Hospital Affiliated to China Medical University, the average time spent by pharmacists dispensing single prescriptions containing different quantities of prescriptions was obtained (Figure 8). On average, each pharmacist dispensed 1,541 prescriptions per month, and the average Contains about 8.36 medicinal material items. Since scientific Chinese medicine is a powder, the powder will scatter in the air during dispensing. Therefore, about 1.06 grams of medicinal powder are lost during dispensing of each prescription, so each item loses about 0.13 grams. Assuming that each medicinal material item averages about 2.57 yuan per gram, the loss of each additional medicine is 0.326 yuan. Therefore, each prescription reduces the adjustment cost of one item, saving about 502 yuan a month.

According to the analysis of the data from the Bureau of Traditional Chinese Medicine of the Hospital Affiliated to China Medical University, if a single prescription consists of 8 Below the drug item, each missing item will reduce the dispensing time by about 0.24 minutes on average. If each prescription is missing one item, each pharmacist can save 370 minutes per month, about 6.2 hours of working time. These saved working hours can make manpower deployment more appropriate and sufficient. Based on a monthly salary of about 55,000 (30,000 technicians), and 40 hours of work per week, each pharmacist can produce an average of about 2,131 yuan per month. . If you are a technician, it is 1,162 yuan.

Combining the above two advantages, assuming that a medical unit has X orders per month, and the average number of items reduced by each prescription is Y, the use of the streamlined prescription system can bring: (((2,131+502)*Number of pharmacists) +((1,162+502)*Number of technicians))*(X*Y)/1,541 yuan output value. Example: If X=1000, Y=1, number of pharmacists=0, number of technicians=1, it can bring: (((2,131+502)*0)+((1,162+502)*1))*( 1000*1)/1,541=1,079 yuan output value.

10: An intelligent prescription system for traditional Chinese medicine

20: Database

30: System service server

40: Prescription input module

50: Data processing module

60: Display device

Claims (12)

An intelligent prescription system for traditional Chinese medicine, comprising: a database for storing and providing multiple prescriptions of traditional Chinese medicines and single prescriptions, including their drug composition and original dose of medication; and a system service server connected to the database, wherein The system service server includes: a prescription input module for inputting a D prescription, including N prescriptions, wherein the N prescriptions include one or more X compound prescriptions and Z single prescriptions, and a data processing module for To receive and store the D prescription, compare, analyze and screen the D prescription with the drug composition and the original dosage of the drug in the database, so as to streamline the D prescription, so as to obtain a simplified prescription G, This process includes: providing D prescriptions containing N prescriptions, expressed as: D prescriptions=E ₁ +E ₂ +...E _N , where E ₁ , E ₂ ...E _N are different prescriptions, and the N prescriptions include X prescriptions Compound prescriptions and Z single prescriptions, wherein the Z single prescriptions are composed of none or one or more single herbs, and the D prescription contains the X compound prescriptions and the n unrepeated single herbs in the Z single prescriptions, Among the n non-repetitive single herbs, the G ₁ compound composed of the most F ₁ single herbs can be used, and the most F _f single herbs can be found from the remaining (nF _f-1 ) single herbs Composition and least redundant single drug G _f compound, where n

F _f , f>1, obtain a simplified prescription G through the above process: G ₁ +G ₂ +...G _f (compound), N>f. According to claim 1, the intelligent prescription system for traditional Chinese medicine further includes an output device for outputting the input prescription and the simplified prescription. Such as the traditional Chinese medicine intelligent prescription system of claim 1, wherein the composition of the medicine and the original dosage of the medicine are from the content of the prescription ingredients marked on the Chinese medicine license. For example, the TCM intelligent prescription system of claim 1 further includes a compound prescription simplification selection module, which is used to select the simplification prescription G according to the following process to obtain a simplification selection prescription: There are H ₁ types, and there are also H ₁ types of remaining single herbal medicines, then use the H ₁ remaining single herbal medicines to find out the compound formula that can be composed of the most single herbal medicines and the least redundant single herbal medicines, If the number of components is the same as the number of redundant single medicines, then proceed according to the previous process, and the number of components is the same as the number of redundant single medicines for a total of I times, and finally from H ₁ * H ₂ *... * H _I kinds of prescriptions Among them, pick out a total of h kinds of prescriptions with the fewest compound prescriptions. Such as the TCM intelligent prescription system of claim 4, wherein the prescriptions of the h types of the least compound prescriptions will be presented on the TCM intelligent prescription system to prompt the doctor, if the doctor chooses any one of the h types of the least number of compound prescriptions, then this prescription will replace The D prescription. For example, the TCM intelligent prescription system of claim 2, wherein the actual dosage of each single herbal medicine corresponding to the compound formula before concentration is converted into the original dosage of the single herbal medicine, which will be displayed on the output device. For example, the intelligent prescription system of traditional Chinese medicine according to claim 6, wherein after the original dose of the single herb is compared, if it exceeds the safe dosage of the medicine in the database, the system will prompt. Such as the TCM intelligent prescription system of claim 1, wherein the safe dosage of medicines in the database is the safe dosage of single medicine extracted from the usage and dosage of all medicinal materials in the Pharmacopoeia. Such as the TCM intelligent prescription system of claim 6, wherein the composition of each single drug corresponding to the compound and the real dosage before concentration are presented in a bar graph or a block graph. A method for intelligent prescription of traditional Chinese medicine, including: providing computer products, including: a database for storing and providing multiple Chinese medicine compound prescriptions and single prescription compositions, including their drug composition and original dosage of medication, and a system service server , connected to the database, wherein the system service server includes a prescription input module and a data processing module, wherein the computer product is used to execute steps after loading a program; input a D prescriptions, including N prescriptions, wherein the N prescriptions include one or more X compound prescriptions and Z single prescriptions; and receiving and storing the D prescriptions through the data processing module, and linking the D prescriptions to the database Comparing, analyzing and screening the composition of the drug and the original dosage of the drug, in order to simplify the processing of the D prescription, so as to obtain a simplified prescription G, the processing includes: providing a D prescription containing N prescriptions, expressed as: D prescription =E ₁ +E ₂ +...E _N , where E ₁ , E ₂ ...E _N . are different prescriptions, and the N prescriptions include X compound prescriptions and Z single prescriptions, wherein the Z single prescriptions are none or one or Composed of a variety of single herbal medicines, where the D prescription contains the X compound prescription and the n unique single herbal medicines in the Z pen single prescription. Among the n unique single herbal medicines, at most F ₁ single herbal medicines can be used From the remaining (nF _f-1 ) single herbs, find the G _f compound that can be composed of the _most F _f single herbs and the least redundant single herbs, where n

F _f , f>1, thereby obtaining a simplified prescription G: G ₁ +G ₂ +...G _f (compound), N>f. Such as the TCM intelligent prescription method of claim item 10, it also includes a compound prescription simplification selection step, which step selects the simplification prescription G according to the following process, and obtains a simplification selection prescription : ₁ , then there are H ₁ remaining single herb compositions, then use these H ₁ remaining single herb compositions to find out the compound formula that can be composed of the most single herbal medicines and the least redundant single herbal medicines, if Occur again that the composition quantity is the same as the redundant single herbal medicine quantity, then process according to the previous step, the composition quantity and the redundant single herbal medicine quantity are the same for I times, at last from the H ₁ * H ₂ *...* H _I kinds of prescriptions , pick out a total of h kinds of prescriptions with the least number of compound prescriptions. For example, the intelligent prescription method of traditional Chinese medicine according to claim 11, wherein the prescription of the h least number of compound prescriptions will be presented on the system to prompt the doctor, and if the doctor chooses any one of the h kinds of least number of compound prescriptions, then this prescription will replace the D prescription.

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