TWI795799B - Antibacterial hydrophobic agent composition and its application - Google Patents

Abstract

The invention provides an antibacterial hydrophobic agent composition and application and application method thereof, the antibacterial hydrophobic agent composition, which comprises a hydrophobic agent, an organic antibacterial compound and a solvent, wherein the hydrophobic agent is provided with a first reaction active end and at least one second reaction active end. The organic antibacterial compound is an organic antibacterial compound with a hydroxyl group or an amine group, and the solvent is an aqueous solvent or an organic hydrophilic solvent. Accordingly, the organic antibacterial compound is covalently bonded to the first reactive end to form antibacterial hydrophobic organic compound with an organic antibacterial end. When the antibacterial hydrophobic organic compound contacts the hydrophilic substrate, the second reactive end and the hydrophilic substrate are dehydrated to form a covalent bond, thereby attaching to the surface of the hydrophilic substrate to form a hydrophobic antibacterial layer. The organic antibacterial end of the hydrophobic organic compound is not susceptible to being washed away by water.

Description

Antibacterial hydrophobic agent composition and its application and application method

The present invention relates to an antibacterial chemical; in particular, it refers to an innovative technology discloser of an antibacterial hydrophobic agent composition and its application and application method.

A known foamable alcoholic composition is an antimicrobial chemical comprising a monohydric alcohol, a dimethicone surfactant and a synergist in an amount sufficient to provide antimicrobial activity, by providing a better shear Compositions that reduce viscosity and can be more easily rubbed on sensitive tissues provide advantages for foams for disinfecting skin, and generally dry faster than gels when applied to surfaces such as hands, said The foamable alcoholic composition is suitable for application to the skin and can be used as a hand sanitizer.

After investigation, it is found that the following problems and disadvantages still exist in this prior art in the actual application experience: the foamable alcohol composition is simply the monohydric alcohol, the dimethicone surfactant and the synergistic The surfactant is mixed, and the surface active effect of the dimethicone surfactant and the antibacterial effect of the monohydric alcohol are likely to interfere with each other.

Therefore, in view of the above-mentioned problems existing in the conventional foamable alcohol composition technology, how to develop an innovative technology that can be more ideal and practical is really waiting for the relevant industry to think about the goal and direction of the breakthrough; In view of this, the inventor has been engaged in the manufacture, development and design of related products for many years. After careful design and careful evaluation for the above-mentioned goals, he finally obtained a practical invention.

The main purpose of the present invention is to provide an antibacterial hydrophobic agent composition and its use and method of use. The technical problem to be solved is how to develop a more ideal and practical new type of antibacterial chemical. Think about innovative breakthroughs.

Based on the above-mentioned purpose, the technical characteristics of the present invention to solve the problem mainly lie in that the antibacterial hydrophobic agent composition includes a hydrophobic agent, an organic antibacterial compound and a solvent, wherein the hydrophobic agent has a first reactive active end and at least one second reactive end Active end, the organic antibacterial compound is a hydroxyl or amine organic antibacterial compound, and the solvent is an aqueous solvent or an organic hydrophilic solvent;

Accordingly, the organic antibacterial compound is covalently bonded to the first reactive active end to form an organic antibacterial end, thereby generating an antibacterial hydrophobic organic compound with hydrophobicity and antibacterial properties, and the second reactive active end is connected to the hydrophilic active end. Dehydration of the substrate produces covalent bonds, thereby forming a hydrophobic antibacterial layer on the surface of the hydrophilic substrate.

The main effects and advantages of the present invention are that it can be applied to the surface of the hydrophilic substrate to be antibacterial, and the surface of the hydrophilic substrate is sprayed or coated with the antibacterial hydrophobic agent composition to form the hydrophobic and antibacterial effect. In the antibacterial layer, the organic antibacterial end of the organic antibacterial compound is not easy to be washed away by water and detached.

The antibacterial hydrophobic agent composition of the present invention includes a hydrophobic agent, an organic antibacterial compound and a solvent, wherein the hydrophobic agent has a first reactive active end and one or more second reactive active ends, and the organic antibacterial compound is a hydroxyl (-OH) or amine group (-NH,-NH ₂ ) organic antibacterial compound, the solvent is an aqueous phase solvent or an organic hydrophilic solvent, and accordingly, the organic antibacterial compound and the first reactive terminal dehydrate or generate hydrogen Covalently bonded to generate an antibacterial hydrophobic organic compound with hydrophobicity and antibacterial properties, and when the antibacterial hydrophobic organic compound contacts a hydrophilic substrate, the second reactive terminal is dehydrated with the hydrophilic substrate to form a covalent bond , thereby attaching to the surface of the hydrophilic substrate to form a hydrophobic antibacterial layer.

Further, the hydrophobic agent has a head group composed of hydrophilic functional groups and a terminal group formed by hydrophobic functional groups, constituting an amphiphilic organic compound with both hydrophilic and hydrophobic properties, and the head The segment has the first reactive end and the second reactive end, and the hydrophobic agent and the organic antibacterial compound can be uniformly dispersed in the solvent.

The antibacterial hydrophobic agent composition of the present invention is used for the surface antibacterial of the hydrophilic substrate. The specific examples of the hydrophilic substrate include glass, textile fibers, plastics and ceramics. The use method is mainly for the surface of the hydrophilic substrate Spraying or coating the antibacterial hydrophobic agent composition, as shown in Figure 1, the antibacterial hydrophobic agent composition is applied to the process of the hydrophilic substrate by means of spraying or coating, the solvent volatilizes, and the organic antibacterial compound Covalently bond with the first reactive active end to form an organic antibacterial end, thereby generating the antibacterial hydrophobic organic compound, the antibacterial hydrophobic organic compound still has at least one second reactive end, and the antibacterial hydrophobic organic compound contacts When the hydrophilic substrate is used, the hydrophilic molecules of the head section and the surface of the hydrophilic substrate generate physical adsorption (physical adsorption), and produce chemical covalent bonding (covalent bonding), so that the head section is attached to the hydrophilic substrate. On the surface of the substrate, the tail section will produce van der Waals interaction, induce (induced) molecules to produce a regular arrangement, and make them self-assembled (self-assembled), thereby forming a hydrophobic antibacterial layer. The organic antibacterial end provides the function of inhibiting bacteria and exerts antibacterial and hydrophobic characteristics.

Figure 2 shows another reaction process in which the antibacterial hydrophobic agent composition of the present invention is used on the hydrophilic substrate, and the antibacterial hydrophobic agent composition is applied to the hydrophilic substrate by means of spraying or coating, The solvent volatilizes, and the second reactive end of the hydrophobic agent is first covalently bonded to the hydrophilic substrate, so that the hydrophobic agent forms a hydrophobic layer on the surface of the hydrophilic substrate, and then, the organic antibacterial compound A covalent bond is formed with the first reactive active end to form the organic antibacterial end, thereby generating the antibacterial hydrophobic organic compound, and the hydrophobic layer is transformed into the hydrophobic antibacterial layer with antibacterial effect.

The third reaction process when the antibacterial hydrophobic agent composition of the present invention is used on the hydrophilic substrate is that the antibacterial hydrophobic agent composition is applied to the hydrophilic substrate by means of spraying or coating. Volatilize, the hydrophobic agent and the organic antibacterial agent contact the hydrophilic substrate, the organic antibacterial compound and the first reactive end are covalently bonded to form the organic antibacterial end, and at the same time, the second reactive end and The hydrophilic substrate produces covalent bonds, thereby forming the antibacterial hydrophobic organic compound, and the antibacterial hydrophobic organic compound forms the hydrophobic antibacterial layer on the surface of the hydrophobic substrate.

Compared with the foamable alcohol composition disclosed in the prior art, the foamable alcohol composition is likely to interfere with each other due to the interfacial activity effect of dimethicone surfactant and the antibacterial effect of monohydric alcohol, so that The foamable alcohol composition is easy to fall off after use, and the persistence of the antibacterial effect is poor, but the present invention is applied to the surface of the hydrophilic substrate to form the hydrophobic antibacterial layer with antibacterial effect, and the organic antibacterial end is not easy to be washed by water And break away.

The composition ratio of the antibacterial hydrophobic agent composition is: 1% by weight of the hydrophobic agent, 0.2-0.8% by weight of the antibacterial agent, and 98.8-98.2% by weight of the solvent. The solvent is a mixture of water and alcohol. Based on the hydrophobic agent 1% by weight, the antibacterial agent is 0.2% to 0.8% by weight, the consumption of the water is 97.8% to 48.6% by weight, and the consumption of the alcohol is 1% to 49.6% by weight; based on the total amount of the solvent being 98.8% to 98.2% by weight, the amount of the water The dosage is 79.04~78.56% by weight, and the dosage of the alcohol is 19.76~19.64% by weight, which is a better implementation choice; moreover, based on the solvent being mixed with water and alcohol, the solvent can be replaced by weight percent if necessary Alcohol with a concentration of 19%~21% is another feasible implementation option.

The hydrophobic agent is selected from long-chain siloxane organic compounds or short-chain sodium methylsilicomate (Sodium Methylsilicomate, commonly referred to as SMS). The hydrophobic agent may also include the siloxane organic compound and the methyl Sodium silicate, and the hydrophobic agent is mainly composed of the siloxane organic compound and the sodium methyl silicate, which is a better choice for implementation, Trichloro(octyl)silane (commonly known as TOS) It is an implementation option of the long-chain siloxane organic compound.

The organic antibacterial compound is 3-methyl-4-isopropylphenol (4-Isopropyl- m-cresol), 4-Chloro-3,5-dimethylphenol, 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Benzalkonium chioride , Benzethonium chioride, Chlorhexine gluconate, Chloroxyleol, Homosulfamine, Biphenyl-2-ol, 1-hydroxy-4-methyl-6-(2, 4,4-trimethylpentyl)-2pyridine 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon or triclocarban 1-(4-Chlorophenyl)-3- (3,4-dichlorophenyl)urea.

The organic antibacterial compound can be adsorbed on the cell wall of bacteria, and then penetrate the cell wall to react with lipids and proteins in the cytoplasm, leading to protein denaturation, and then killing cells.

The trichlorooctylsilane belongs to the organosilane compound, and the trichlorooctylsilane will be hydrolyzed to form an intermediate reactant of trimethoxysilane, the chemical structure is as follows, and it is stably dispersed in the solvent at the same time as the organic antibacterial compound, When contacting the hydrophilic substrate, after the solvent gradually volatilizes, the oxysilane will form a bond with the hydrophilic substrate through hydrogen bonds or covalent bonds and undergo a dehydration condensation reaction. At the same time, the organic antibacterial compound also has a hydroxyl function A small amount of the organic antibacterial compound competes with the hydroxyl group of the hydrophilic substrate to obtain the hydrophobic antibacterial layer with both hydrophobic and antibacterial properties.

The molecular formula of the sodium methyl silicate is (CH ₃ ) 3SiONa, and the chemical structure is shown below.

The dosage ratio of the embodiment is shown in Table 1 below, wherein TOS represents the trichlorooctylsilane, SMS represents the sodium methyl silicate, and the antibacterial agent represents the organic antibacterial compound. Table I TOS (wt%) SMS (weight%) Antibacterial agent (weight%) Water (wt%) Alcohol (wt%) Embodiment one - 1 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment two 0.2 0.8 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment three 0.4 0.6 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment Four 0.6 0.4 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment five 0.7 0.3 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment six 0.8 0.2 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment seven 0.9 0.1 0.2~0.8 79.04~78.65 19.76~19.64 Embodiment eight 1 - 0.2~0.8 79.04~78.65 19.76~19.64

As shown in Figure 3, the antibacterial and hydrophobic agent composition is applied on the hydrophilic substrate 10 to form the hydrophobic antibacterial layer 20. When water 30 falls on the surface of the hydrophobic antibacterial layer 20, the distance between the hydrophobic antibacterial layer 20 and the water 30 The contact angle θ between the hydrophobic antibacterial layer 20 and the water 30 formed in each embodiment is shown in Table 2 below. Table II Example contact angle θ Embodiment one 95.4∘±0∘ Embodiment two 92.6∘±0.7∘ Embodiment three 90∘±0.7∘ Embodiment four 89.3∘±0.7∘ Embodiment five 94∘±0∘ Embodiment six 101.8∘±0.1∘ Embodiment seven 96.2∘±0.4∘ Embodiment eight 87.26∘±1.07∘

The hydrophobic agent is mainly composed of the trichlorooctyl silane and the sodium methyl silicate and becomes a better implementation choice, wherein based on the total amount of the hydrophobic agent being 100% by weight, the trichlorooctyl silane is 70-90% % by weight, 30-10% by weight of the sodium methyl silicate is a better implementation choice. Based on the consideration of hydrophobicity, it is also a better implementation choice to use the sodium methyl silicate alone as the hydrophobic agent.

As shown in Figure 4, the long chain 22 and the short chain 24 formed by the trichlorooctyl silane and the sodium methyl silicate two hydrophobic agents are arranged in an orderly manner, which will generate air defects and provide additional hydrophobic forces. , to improve the characteristic of hydrophobicity, wherein a first reactive active end 26 is chelated with the organic antibacterial compound to form an organic antibacterial end 27, and two second reactive active ends 28 are respectively covalently bonded with the hydrophilic substrate 10 to form a combination End 29.

Under the condition of ambient humidity of 50%~80%, the antibacterial hydrophobic agent composition was tested, and applied on the surface of the hydrophilic substrate 10 to form the hydrophobic antibacterial layer 20, wherein the trichlorooctylsilane and the methyl silicon When sodium nitrate is mixed in different proportions to form the hydrophobic agent, the relationship between the proportion of the amount of trichlorooctylsilane relative to the hydrophobic agent and the contact angle θ is shown in the line graph in Figure 5, where the horizontal axis represents the trichlorooctylsilane The amount of silane relative to the total amount of the hydrophobic agent is 100% by weight, the unit is weight %, the vertical axis represents the angle of the contact angle θ, the unit is degree, the larger the angle of the contact angle θ, the higher the hydrophobicity, and When the amount of the trichlorooctylsilane is 0% by weight, it represents the first embodiment in which the sodium methyl silicate is used as the hydrophobic agent alone.

As can be seen from Fig. 5, the total amount of the hydrophobic agent is 100% by weight, and when the trichlorooctylsilane is 70 to 90% by weight, the hydrophobicity of the hydrophobic antibacterial layer 20 is better than that of using the trichlorooctylsilane alone as the The implementation selection of the hydrophobic agent is based on the consideration of hydrophobicity, and the sodium methyl silicate alone can also be a better implementation selection.

The present invention breaks through the limit of the intrinsic hydrophobicity of the material by mixing two kinds of hydrophobic agents with long chain and short chain. Chloroctyl silane is used as the eighth embodiment of the hydrophobic agent. The contact angle θ between the hydrophobic antibacterial layer 20 and the hydrophilic substrate 10 formed in the first embodiment is 95.4 ^° , which is obviously better than the eighth embodiment. As can be seen from FIG. 5, When the trichlorooctylsilane and the sodium methyl silicate are used in combination as the hydrophobic agent, based on 100% by weight of the total amount of the hydrophobic agent, the amount of the trichlorooctylsilane is 72 to 90% by weight, and the methyl silicon The consumption of sodium nitrate is 18～10% by weight, and this contact angle θ is all greater than embodiment one, and is the implementation selection that is better than embodiment one.

10: Hydrophilic substrate 20: Hydrophobic antibacterial layer 22: long chain 24: short chain 26: the first reactive end 27:Organic antibacterial end 28: the second reactive terminal 29: binding end 30: water θ: contact angle

Fig. 1 is the reaction flow chart of the embodiment of the present invention. Fig. 2 is another kind of reaction flowchart of the embodiment of the present invention. Fig. 3 is a schematic diagram of the contact angle between the hydrophobic antibacterial layer formed by the embodiment of the present invention and water. Figure 4 is a schematic diagram of the state of covalent bonding between two hydrophobic agents, trichlorooctylsilane and sodium methyl silicate, and a hydrophilic substrate. Fig. 5 is a line diagram of the relationship between the contact angle between the hydrophobic antibacterial layer and water formed in the embodiment of the present invention.

Claims (10)

An antibacterial hydrophobic agent composition, including a hydrophobic agent, an organic antibacterial compound and a solvent, wherein the hydrophobic agent has a first reactive active end and at least one second reactive active end, and the organic antibacterial compound is an organic compound with a hydroxyl group or an amino group. An antibacterial compound, the solvent is an aqueous phase solvent or an organic hydrophilic solvent; accordingly, the organic antibacterial compound is covalently bonded to the first reactive active end to form an organic antibacterial end, thereby generating an antibacterial hydrophobic An organic compound, the second reactive end is dehydrated with the hydrophilic substrate to form a covalent bond, thereby forming a hydrophobic antibacterial layer on the surface of the hydrophilic substrate. The antibacterial hydrophobic agent composition as described in Claim 1, wherein the hydrophobic agent is 1% by weight, the antibacterial agent is 0.2~0.8% by weight, and the solvent is 98.2~98.8% by weight. The antibacterial hydrophobic agent composition as described in claim 2, wherein the solvent is a mixture of water and alcohol, based on 1% by weight of the hydrophobic agent, the antibacterial agent is 0.2-0.8% by weight, and the amount of water is 48.6-97.8 % by weight, the amount of the alcohol is 1 to 49.6% by weight. The antibacterial hydrophobic agent composition as described in Claim 1, wherein the hydrophobic agent is selected from at least one of long-chain siloxane organic compounds and short-chain sodium methyl silicate. The antibacterial hydrophobic agent composition according to claim 4, wherein the siloxane organic compound is a trimethoxysilane intermediate reactant formed by hydrolysis of trichlorooctylsilane. The antibacterial hydrophobic agent composition as described in claim 4, wherein the hydrophobic agent includes the trimethoxysilane intermediate reactant formed by the hydrolysis of the trichlorooctylsilane and the sodium methyl silicate. The antibacterial hydrophobic agent composition as described in claim 6, wherein, based on the total amount of the hydrophobic agent is 100% by weight, the trichlorooctylsilane is 70-90% by weight, and the sodium methyl silicate is 10-30% by weight. weight%. The antibacterial hydrophobic agent composition as described in claim item 1, wherein the organic antibacterial compound is 3-methyl-4-isopropylphenol, chloroxylenol, dichlorophenoxychlorophen, benzalkonium chloride, benzyl Chloramine, chlorhexidine, p-chloro-m-xylenol, sulfasulfame, o-cresol, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridine or Triclocarban. A use of the antibacterial hydrophobic agent composition as described in any one of claims 1 to 8, which is used for surface antibacterial of hydrophilic substrates. A method of using the antibacterial hydrophobic agent composition as described in any one of claims 1 to 8, which is to spray or coat the antibacterial hydrophobic agent composition on the surface of a hydrophilic substrate.

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