TWI792666B - Measuring urine sugar concentration device - Google Patents
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Abstract
本發明揭露一種可量測尿糖濃度裝置,包含稜鏡本體及殼體。稜鏡本體包含第一容置空間、交界面、第一透光面、第二透光面、第三透光面及出光面。第一容置空間容置尿液。交界面形成於第一容置空間底面。第一透光面形成於第一容置空間的第一側面。第二透光面相對第一透光面形成於第一容置空間的第二側面。第三透光面相對交界面設置。出光面與交界面對應設置。殼體包含第二容置空間、第一出光口及第二出光口。第二容置空間容置稜鏡本體。第一出光口具有第一口徑,並與稜鏡本體之出光面對應設置。第二出光口具有第二口徑,並與第一出光口對應設置,其中第一口徑小於或等於第二口徑。The invention discloses a device capable of measuring the concentration of urine sugar, which includes a body and a casing. The main body includes a first accommodating space, an interface, a first light-transmitting surface, a second light-transmitting surface, a third light-transmitting surface and a light-emitting surface. The first accommodation space accommodates urine. The interface is formed on the bottom surface of the first accommodating space. The first light-transmitting surface is formed on a first side surface of the first accommodating space. The second light-transmitting surface is formed on a second side of the first accommodating space opposite to the first light-transmitting surface. The third transparent surface is arranged opposite to the interface surface. The light-emitting surface and the interface are set correspondingly. The casing includes a second accommodating space, a first light outlet and a second light outlet. The second accommodating space accommodates the 稜鏡 body. The first light outlet has a first diameter and is set corresponding to the light outlet surface of the main body. The second light outlet has a second diameter and is set corresponding to the first light outlet, wherein the first diameter is smaller than or equal to the second diameter.
Description
本發明係有關於一種可量測液體濃度之裝置,特別是有關於一種可量測尿糖濃度裝置。The present invention relates to a device capable of measuring liquid concentration, in particular to a device capable of measuring urine sugar concentration.
尿糖的數值高低表示腎絲球、濾過血液內糖分過高,使得腎小管無法全部吸收,而由尿液排出稱為尿糖。一般而言,血糖超過180mg/dL時,則尿液會出現糖分。如果檢測尿糖的結果出現陽性,表示受測者可能具有糖尿病、胰臟炎、肝病變、甲狀腺疾病等風險。The high or low value of urine sugar indicates that the glomerular and filtrated blood sugar is too high, so that the renal tubules cannot fully absorb it, and it is excreted in urine as urine sugar. Generally speaking, when the blood sugar exceeds 180mg/dL, there will be sugar in the urine. If the urine sugar test results are positive, it means that the subject may have risks such as diabetes, pancreatitis, liver disease, and thyroid disease.
尿糖偏高經常是判定為血糖偏高的因果關係之一,然而,因為目前血糖檢查為侵入式抽取血液檢測,造成受測者的心理負擔,因而降低受測者持續進行檢測的意願。因此,常有受測者延誤檢測後,發現血糖偏高而已造成上述病變的情況發生。High urine sugar is often one of the causal relationships that determine high blood sugar. However, because the current blood sugar test is an invasive blood test, it causes a psychological burden on the subject, thus reducing the willingness of the subject to continue testing. Therefore, it is often found that the above-mentioned lesions have been caused by the high blood sugar level after the testee delays the test.
此外,尿糖檢測目前以酵素法為主,其中又以葡萄糖氧化酶法之試紙檢測最普遍。然而,試紙檢測雖然費用低廉,但對於終端使用者來說,試紙測定時間需要30-60秒,並無即時性。再者,人眼判讀試紙顏色變化容易造成人為誤差,因而缺乏效率。同時,試紙存在有保存問題,容易因為空氣與溼氣而劣化,因而影響尿糖性能的判斷。In addition, the urine glucose test is currently mainly based on the enzyme method, of which the glucose oxidase method is the most common. However, although the cost of test paper detection is low, for end users, the test paper measurement time needs 30-60 seconds, and there is no real-time. Furthermore, human eyes may easily cause human error when interpreting the color change of the test paper, thus lacking in efficiency. At the same time, there is a storage problem with the test paper, which is easy to deteriorate due to air and moisture, thus affecting the judgment of the performance of urine sugar.
由於國人糖尿病的情況普遍嚴重,因此,如何提供一種非侵入式檢測裝置,幫助受測者以非侵入式方式檢測尿糖已成為目前急需研究的課題。Since diabetes is generally serious in Chinese people, how to provide a non-invasive detection device to help subjects detect urine sugar in a non-invasive manner has become an urgent research topic.
鑑於上述問題,本發明揭露一種可量測尿糖濃度裝置,包含稜鏡本體及殼體。稜鏡本體包含第一容置空間、交界面、第一透光面、第二透光面、第三透光面及出光面。第一容置空間容置尿液。交界面形成於第一容置空間的底面。第一透光面形成於第一容置空間的第一側面。第二透光面相對第一透光面形成於第一容置空間的第二側面。第三透光面相對交界面設置。出光面與交界面對應設置。殼體包含第二容置空間、第一出光口及第二出光口。第二容置空間容置稜鏡本體。第一出光口具有第一口徑,並與稜鏡本體的出光面對應設置。第二出光口具有第二口徑,並與第一出光口對應設置,其中第一口徑小於或等於第二口徑。當第一入射光束入射至稜鏡本體內部後,第一入射光束射向交界面,並由交界面反射到出光面後,由出光面射出稜鏡本體內部,並通過第一出光口及第二出光口射出殼體內部。當第二入射光束入射稜鏡本體內部後,第二入射光束射向第一透光面,並由第一透光面射出稜鏡本體內部後,入射至第一容置空間,且穿透第一容置空間內的尿液,再入射至第二透光面,由第二透光面入射稜鏡本體內部後,射向第三透光面,由第三透光面射出稜鏡本體內部,其中可量測尿糖濃度裝置根據射出該殼體內部之該第一入射光束計算一折光度,以及根據射出該稜鏡本體內部之該第二入射光束計算一吸光度,並根據該折光度及該吸光度計算一尿糖濃度。In view of the above problems, the present invention discloses a device capable of measuring urine sugar concentration, which includes a body and a casing. The main body includes a first accommodating space, an interface, a first light-transmitting surface, a second light-transmitting surface, a third light-transmitting surface and a light-emitting surface. The first accommodation space accommodates urine. The interface is formed on the bottom surface of the first accommodating space. The first light-transmitting surface is formed on a first side surface of the first accommodating space. The second light-transmitting surface is formed on a second side of the first accommodating space opposite to the first light-transmitting surface. The third transparent surface is arranged opposite to the interface surface. The light-emitting surface and the interface are set correspondingly. The casing includes a second accommodating space, a first light outlet and a second light outlet. The second accommodating space accommodates the 稜鏡 body. The first light outlet has a first diameter, and is set corresponding to the light outlet surface of the main body. The second light outlet has a second diameter and is set corresponding to the first light outlet, wherein the first diameter is smaller than or equal to the second diameter. When the first incident light beam enters the inside of the main body, the first incident light beam hits the interface, is reflected from the interface to the light-emitting surface, and then exits the inside of the main body from the light-emitting surface, and passes through the first light outlet and The second light outlet exits the inside of the casing. When the second incident light beam enters the inside of the main body, the second incident light beam hits the first light-transmitting surface, exits the inside of the main body from the first light-transmitting surface, enters the first accommodating space, and passes through the first light-transmitting surface. The urine in the first accommodating space is incident on the second light-transmitting surface, and after entering the inside of the body from the second light-transmitting surface, it shoots to the third light-transmitting surface, and emits the prism from the third light-transmitting surface. inside the mirror body, wherein the device for measuring urine sugar concentration calculates a refraction according to the first incident light beam emitted from the inside of the housing, and calculates an absorbance according to the second incident light beam emitted from the inside of the body, and A urine sugar concentration is calculated according to the refractive index and the absorbance.
承上所述,本發明可量測尿糖濃度裝置可同時或者個別檢測光線的折光度與吸光度,結合吸光與折光特性,可對尿液進行尿糖濃度分析,並且無需使用聚光元件作為光源,因而具有簡化光路校正(alignment)的優點。再者,本發明可量測尿糖濃度裝置無需設置透鏡或目鏡等結構,可使整體結構的體積縮小。此外,本發明可量測尿糖濃度裝置無需使用濾片或偏極片等結構,可降低生產成本。再者,本發明可量測尿糖濃度裝置針對尿糖的檢測具有多項優點,包含不須添加化學試劑、不須試紙、透過儀器判讀檢測資訊而降低人為判讀誤差、透過光學檢測而無氧氣與溼氣劣化問題、透過光學檢測可提高檢測頻率以及容易收集測試數據進行統計分析與即時健康管理。Based on the above, the device for measuring the concentration of urine sugar in the present invention can detect the refraction and absorbance of light at the same time or individually, and combine the light absorption and refraction characteristics to analyze the concentration of urine sugar in urine without using a light-concentrating element as a light source , thus having the advantage of simplifying the alignment of the optical path. Furthermore, the urine sugar concentration measuring device of the present invention does not need to be provided with structures such as lenses or eyepieces, which can reduce the volume of the overall structure. In addition, the urine sugar concentration measuring device of the present invention does not need to use structures such as filters or polarizers, which can reduce production costs. Furthermore, the urine sugar concentration measuring device of the present invention has many advantages for the detection of urine sugar, including no need to add chemical reagents, no test paper, reduce human interpretation errors through instrument interpretation of detection information, and optical detection without oxygen and The problem of moisture degradation, the detection frequency can be increased through optical detection, and the test data can be easily collected for statistical analysis and real-time health management.
請參閱圖1A及圖1B,其係為本發明可量測尿糖濃度裝置的稜鏡本體的第一立體圖及第二立體圖。稜鏡本體1包含第一容置空間10、第一透光面11、第二透光面12、第三透光面13及出光面14。第一容置空間10容置尿液Q。交界面100形成於第一容置空間10的底面。第一透光面11形成於第一容置空間10的第一側面。第二透光面12相對第一透光面11形成於第一容置空間10的第二側面。第三透光面13相對交界面100設置。出光面14與交界面100對應設置。Please refer to FIG. 1A and FIG. 1B , which are the first perspective view and the second perspective view of the main body of the urine sugar concentration measuring device of the present invention. The
請參閱圖2A至圖2D,其係為本發明可量測尿糖濃度裝置的立體圖、分解圖、上視圖及剖視圖。可量測尿糖濃度裝置3包含稜鏡本體1及殼體2。殼體2包含第二容置空間20、第一出光口21及第二出光口22。第二容置空間20容置稜鏡本體1。第一出光口21具有第一口徑,並與稜鏡本體1的出光面14對應設置。第二出光口22具有第二口徑,並與第一出光口21對應設置,其中第一口徑小於或等於第二口徑。再者,於本發明的一實施例中,第一出光口21係為單狹縫的形狀,且第一出光口21與第二出光口22係形成喇叭狀開口,亦即第一出光口21到第二出光口22的口徑大小係由窄逐漸變寬。此外,殼體2更包含一啟動鍵23、一顯示單元24以及一電源鍵25。啟動鍵23控制第一光源S1、第一光線感測器D1、第二光源S2、第二光線感測器D2及顯示單元24的開啟與關閉。顯示單元24顯示尿液的量測數據結果,亦即顯示尿糖濃度數值。電源鍵25電性連接供電單元(未圖示),供電單元電性連接顯示單元24、啟動鍵25以及各個光源,以供給該些元件電力。Please refer to FIG. 2A to FIG. 2D , which are perspective views, exploded views, top views and cross-sectional views of the device for measuring urine sugar concentration of the present invention. The
請參閱圖2B,可量測尿糖濃度裝置更包含一外壁26、一第一光源S1、一第一光線感測器D1、一第二光源S2以及一第二光線感測器D2。外壁26貼合殼體2的一表面及稜鏡本體1的入光面15(如圖1A所示),以形成稜鏡本體1的第一容置空間10。進一步而言,由於稜鏡本體1的第一容置空間10係為一開放空間,因此,於本發明之一實施例中,係透過外壁26貼合稜鏡本體1的入光面15,使第一容置空間10成為可容置尿液的一容置空間。於本發明其它實施例中,稜鏡本體1的第一容置空間10亦可為一可容置尿液的封閉空間。第一光源S1設置於外壁26上、交界面100下方的位置,產生第一入射光束L1。換句話說,第一入射光束L1係由下往上入射到交界面100。第一光線感測器D1設置於第二出光口22上,接收第一入射光束L1,其中殼體2的表面係平行於第二出光口22。殼體2更包含第一容置槽27及第二容置槽28,第二光源S2設置於殼體2的第一容置槽27中,產生第二入射光束L2。第二光線感測器D2設置於殼體2的第二容置槽28中,接收第二入射光束L2,其中第一容置槽27與第二容置槽28係平行設置。Please refer to FIG. 2B , the urine sugar concentration measuring device further includes an
請參閱圖2D,稜鏡本體1的出光面14與殼體2第二容置空間20的底部表面形成簍空空間30,其係為光線傳遞的空間,使第一入射光束L1由稜鏡本體1的出光面14射出稜鏡本體1內部後,通過簍空空間30、第一出光口21及第二出光口22射出殼體2內部,並射向設置於第二出光口22上的第一光線感測器D1。Please refer to FIG. 2D, the light-emitting
請參閱圖3A及圖3B,其係為本發明可量測尿糖濃度裝置的光線反射示意圖及光線穿透液體示意圖。如圖3A所示,並配合參閱圖2D,第一光源S1產生的第一入射光束L1入射至稜鏡本體1內部後,第一入射光束L1射向交界面100,並由交界面100反射到出光面14後,由出光面14射出稜鏡本體1內部,並通過第一出光口21及第二出光口22入射到設置於殼體2出光口22的第一光線感測器D1,藉此量測尿液Q的折光度。如圖3B所示,並配合參閱圖2B,第二光源S2產生的第二入射光束L2入射稜鏡本體內部後,第二入射光束L2射向第一透光面11,並由第一透光面11射出稜鏡本體內部後,入射至第一容置空間10,且穿透第一容置空間10內的尿液Q,再入射至第二透光面12,由第二透光面12入射稜鏡本體內部後,射向第三透光面13,由第三透光面13射出稜鏡本體內部,並入射到設置於殼體2內的第二光線感測器D2。尿液Q的濃度藉由第一光線感測器D1量測穿出該出光面14、第一出光口21及第二出光口22的第一入射光束L1計算,尿液Q的吸光度藉由第二光線感測器D2量測穿出第三透光面13的第二入射光束D2計算。Please refer to FIG. 3A and FIG. 3B , which are schematic diagrams of light reflection and light penetration through liquid of the apparatus for measuring urine sugar concentration of the present invention. As shown in FIG. 3A , and with reference to FIG. 2D , after the first incident light beam L1 generated by the first light source S1 is incident on the inside of the
承上所述,根據基本光學原理可知,光線進入到不同介質中,光線會產生折射現象,同時也會產生反射,因此,將第一光線感測器D1設置在殼體的第二出光口22,藉由量測接收到反射的第一入射光束L1的光線亮度(折光度)可計算出尿液Q濃度。此外,當光線穿透過尿液Q後,由於尿液Q會吸收光線能量,使得光線亮度減弱,因此,將第二光線感測器D2設置在殼體上,藉由量測接收到第二入射光束L2的光線亮度可計算出尿液Q的吸光度。Based on the above, according to the basic optical principle, it can be known that when light enters different media, the light will be refracted and reflected at the same time. Therefore, the first light sensor D1 is arranged at the second
如圖1A、圖1B及圖3A所示,稜鏡本體1更包含一入光面15,鄰接交界面100。於本發明之一實施例中,入光面15係垂直相鄰連接交界面100。第一光源S1的第一入射光束L1經由入光面15入射至稜鏡本體1內部,再射向交界面100。As shown in FIG. 1A , FIG. 1B and FIG. 3A , the
如圖1A、圖1B及圖3B所示,第三透光面13係鄰接入光面15。於本發明之一實施例中,第三透光面13與入光面15係垂直鄰接,且第二入射光束L2係自第三透光面13入射稜鏡本體1內部後,再射向第一透光面11。As shown in FIG. 1A , FIG. 1B and FIG. 3B , the third light-transmitting
如圖3A所示,出光面14係鄰接第三透光面13,且出光面14與入光面15分別鄰接於第三透光面13的相對兩側。出光面14與第三透光面13之間具有一夾角θ,且該夾角θ係為鈍角,介於105度至165度之間。於本發明之一較佳實施例中,該夾角θ為135度。As shown in FIG. 3A , the light-emitting
請參閱圖3B,稜鏡本體1更包含第一反光面16及第二反光面17。當第二光源S2產生的第二入射光束L2入射稜鏡本體1內部後,第二入射光束L2先射向第一反光面16,並於通過第一反光面16反射後,射向第一透光面11,由第一透光面11射出稜鏡本體1內部後,入射至第一容置空間10,且穿透第一容置空間10內的尿液Q,再入射至第二透光面12,由第二透光面12入射稜鏡本體1內部後,射向第二反光面17,再通過第二反光面17反射後,射向第三透光面13,再由第三透光面13射出稜鏡本體1內部,並入射到設置於殼體體2內的第二光線感測器D2。第一反光面16鄰接第一透光面11,並與第一透光面之間具有第一夾角θ1,第一夾角θ1係為銳角,介於15度至75度之間。於本發明之一較佳實施例中,第一夾角θ1較佳為45度。第一反光面16係根據第二入射光束L2入射第三透光面13的角度,以第一夾角θ1設置。第二反光面17鄰接第二透光面12,並與第二透光面12之間具有第二夾角θ2,第二夾角θ2係為銳角,介於15度至75度之間。於本發明之一較佳實施例中,第二夾角θ2較佳為45度。第二反光面17係根據第二入射光束L2入射第一反光面16後反射的角度,以第二夾角θ2設置。Please refer to FIG. 3B , the
請再參閱圖3A及圖3B,殼體在本發明之實施例中,第一反光面16及第二反光面17係分別為一三角塊的形狀設置圍繞於第一容置空間10周圍的兩側面,並與第一容置空間10的交界面100(底面)形成該第一容置空間10。需注意的是,雖然第一容置空間10在本發明的圖式中並無法以第一三角塊、第二三角塊以及另一凸塊圍繞形成封閉的空間,但事實上稜鏡本體1設置於殼體2的第二容置空間20中,且入光面15係與殼體2第二容置空間20內的壁面貼合,因而使得稜鏡本體1的第一容置空間10圍繞成一封閉空間,以容置尿液Q。Please refer to FIG. 3A and FIG. 3B again. In the embodiment of the present invention, the first
請參閱圖4A至圖4C,其係為本發明可量測尿糖濃度裝置的反射光線示意圖。如圖所示,稜鏡本體1的出光面14設置在相對入光面15的一側,由交界面100反射的第一入射光束L1通過出光面14、殼體2的第一出光口21及第二出光口22後,入射到第一光線感測器D1。由光學原理可知,欲量測通過出光面14、第一出光口21及第二出光口22的第一入射光束L1,必須針對出光面14的設置角度及面積以及第一出光口21及第二出光口22的口徑進行配置。進一步而言,根據斯涅爾定律(Snell's Law),已知稜鏡本體1的介質折射率以及第一入射光束L1入射到交界面100的入射角,可根據第一入射光束L1在通過不同介質折射率(不同溶液)的交界面100時所產生的反射角度範圍計算出尿液Q的介質折射率。而尿液Q折射率越大,被折射的光線越多,相對的反射光越少,第一光線感測器D1所接收到第一入射光束L1的反射光線越少(如圖4A及圖4B所示),因此,可進一步根據第一入射光束L1入射到不同尿液Q之介質折射率的範圍,所對應產生的反射角度範圍,定義、配置出光面14的預設傾斜角度θ及面積,以及計算出第一出光口21及第二出光口22的口徑大小,亦即,出光面14的預設傾斜角度θ以及預設面積以及第一出光口21及第二出光口22的口徑係根據第一入射光束L1從交界面100所產生的反射角度設置,且預設傾斜角度θ係以交界面100為基準角度設置。Please refer to FIG. 4A to FIG. 4C , which are schematic diagrams of reflected light of the apparatus for measuring urine sugar concentration of the present invention. As shown in the figure, the light-emitting
在本發明的較佳實施例中,第一光源S1係設置於殼體2的外壁26的一穿孔261內,並對應稜鏡本體1入光面15中心的法線位置設置,以使第一入射光束L1能平均入射入光面15。第一光線感測器D1係設置在殼體2第二出光口22上,藉此能平均接收通過出光面14、第一出光口21及第二出光口22的第一入射光束L1。In a preferred embodiment of the present invention, the first light source S1 is arranged in a through
請參閱圖5A至圖5D,其係為本發明第一入射光束入射到可量測尿糖濃度裝置的示意圖。實際上,為了要量測第一入射光束L1入射到稜鏡本體1後的反射光,以及量測第二光束L2穿透過尿液Q後的光線,於本發明之實施例中,第一光源S1及第二光源S2包含鹵素燈、氣體燈、雷射、LED、或者其他發光元件。而針對第一入射光束L1入射到稜鏡本體1後的反射光,由於使用的該些光源所產生的光束係向外360度發出,而對於前半部入射到稜鏡本體1的光線而言,可將其區分為如圖5A至圖5D四個部分的光線。如圖5A所示,當第一入射光束L1入射到稜鏡本體1的交界面100後,其反射光係朝向出光面14射出,並入射到第一光線感測器D1。如圖5B所示,當第一入射光束L1入射到稜鏡本體1後,由於在入射方向上並無可使其產生反射的表面或交界面100,因此,其入射光束係直接朝向稜鏡本體1的外部射出。如圖5C所示,當第一入射光束L1入射到稜鏡本體1的出光面14後,由於第一入射光束L1的入射角度正好與出光面14形成全反射的角度,因而使得反射的第一入射光束L1朝向稜鏡本體1的其它方向射入,並朝向稜鏡本體1的外部射出。如圖5D所示,當第一入射光束L1入射到稜鏡本體1的第三透光面13後,其產生的反射光角度並未朝向出光面14射出,而是朝向稜鏡本體1的其它方向向外射出。據此,設置於第二出光口22的第一光線感測器D1僅接收入射到稜鏡本體1交界面100後的反射光。Please refer to FIG. 5A to FIG. 5D , which are schematic diagrams of the first incident light beam entering the device for measuring urine sugar concentration according to the present invention. Actually, in order to measure the reflected light after the first incident light beam L1 is incident on the
請參閱圖6,其係為本發明尿液濃度與吸光度的關係示意圖。由於尿液Q濃度會造成吸光度的差異,因此,藉由量測尿液Q的吸光度可計算該尿液Q濃度。根據比爾-朗伯定理(Beer–Lambert law),當一平行光線垂直入射樣品後,樣品的吸光物質吸收部分光子能量,使透射光強度減弱,其中被吸收的能量(A)與樣品吸收係數(α)、光程(樣品長度)(L)、濃度(c)三著呈現正相關,表示方法如下: Please refer to FIG. 6 , which is a schematic diagram of the relationship between urine concentration and absorbance in the present invention. Since the concentration of urine Q will cause a difference in absorbance, the concentration of urine Q can be calculated by measuring the absorbance of urine Q. According to the Beer–Lambert law, when a parallel light is incident on the sample vertically, the light-absorbing substance of the sample absorbs part of the photon energy, which weakens the intensity of the transmitted light, and the absorbed energy (A) is related to the sample absorption coefficient ( α), optical path (sample length) (L), and concentration (c) are positively correlated, expressed as follows:
被吸收的能量可視為吸收度(A),因此當光線穿過樣品部分能量被樣品吸收,剩下的光線穿透該樣品,因此可以從入射光(I 0)與透射光(I)的能量差來計算出該樣品吸收度,其吸收度定義如下 The absorbed energy can be regarded as the absorbance (A), so when the light passes through the sample, part of the energy is absorbed by the sample, and the rest of the light passes through the sample, so the energy of the incident light (I 0 ) and the transmitted light (I) can be The absorbance of the sample is calculated by the difference, and the absorbance is defined as follows
再者,第二入射光束L2入射至第一反光面16後,經過第一反光面16反射後透射至尿液Q,尿液Q吸收部分光子能量,使透射光強度減弱,再經過第二反光面17反射到第二光線感測器D2。尿液Q濃度越高,被吸收的光線能量越多,因此透射光強度越弱,從光源強度與透射光的比例可得知吸收度,進而計算出尿液Q濃度。Moreover, after the second incident light beam L2 is incident on the first
請參閱圖7,其係為本發明尿糖濃度與吸光度及折光度的關係示意圖。由於尿液Q的濃度不同,光線的吸光比率也會不同,因此,不同的尿液濃度會有不同的尿糖特性曲線A、B、C。而本發明能量測尿液的吸光度與折光度,並透過量測尿液的吸光度判斷尿糖特性曲線A、B、C後,再藉由量測光線進入尿液Q後的折射率,即尿液的折光度,根據折射率及依據吸光度判斷出的尿糖特性曲線A、B、C,計算出對應的尿糖濃度。於本發明之一實施例中,殼體2更包含一儲存模組(未圖示),儲存一資料庫,資料庫包含多條尿糖特性曲線,以供處理模組快速計算及比對對應的尿糖濃度。Please refer to FIG. 7 , which is a schematic diagram of the relationship between urine sugar concentration, absorbance and refraction in the present invention. Since the concentration of urine Q is different, the light absorption ratio of light will also be different. Therefore, different urine concentrations will have different urine sugar characteristic curves A, B, and C. However, the present invention can measure the absorbance and refraction of urine, and judge the urine sugar characteristic curves A, B, and C by measuring the absorbance of urine, and then measure the refractive index after the light enters the urine Q, namely The refractive index of urine, according to the refractive index and the urine sugar characteristic curves A, B, and C judged based on the absorbance, calculates the corresponding urine sugar concentration. In one embodiment of the present invention, the
舉例來說,尿糖特性曲線A對應的吸光度為a%,尿糖特性曲線B對應的吸光度為b%,尿糖特性曲線C對應的吸光度為c%,且a>b>c,而通過本發明量測到的尿液折光度為n。據此,在計算尿糖濃度時,即可根據上述內容計算出的吸光度a%先決定出尿糖特性曲線A,再根據尿糖特性曲線A以及計算出的折光度為n,計算出對應的尿糖濃度為x(mg/dl)。For example, the absorbance corresponding to the urine sugar characteristic curve A is a%, the absorbance corresponding to the urine sugar characteristic curve B is b%, the absorbance corresponding to the urine sugar characteristic curve C is c%, and a>b>c, and through this The urine refractive index measured by the invention is n. Accordingly, when calculating the urine sugar concentration, the urine sugar characteristic curve A can be determined based on the absorbance a% calculated above, and then the corresponding urine sugar characteristic curve A and the calculated refraction can be calculated as n The urine sugar concentration is x (mg/dl).
請參閱圖8,其係為本發明可量測尿糖濃度裝置方塊示意圖。可量測尿糖濃度裝置3更包含一輸入單元31、一檢測單元32以及一處理單元33,輸入單元31電性連接供電單元,包含第一光源S1及第二光源S2,產生啟動訊號觸發第一光源S1及第二光源S2。檢測單元32包含第一光線感測器D1、第二光線感測器D2,電性連接供電單元及輸入單元31,分別接收及感測第一光源S1及第二光源S2發射的第一入射光束L1及第二入射光束L2,經過尿液、稜鏡本體1的交界面100產生透射、反射及折射的光線。處理單元33電性連接檢測單元32及顯示單元24,並根據第一光線感測器D1接收之第一入射光束L1計算折光度,以及根據第二光線感測器D2接收之第二入射光束L2計算吸光度,並將計算結果顯示在顯示單元24上。Please refer to FIG. 8 , which is a schematic block diagram of a device for measuring urine sugar concentration according to the present invention. The urine sugar
於本發明之一實施例中,稜鏡本體1材質包含玻璃、塑膠、或者其他可透光材料。稜鏡本體1的交界面100、第一透光面11、第二透光面12、第三透光面13、出光面14、入光面15、第一反光面16及第二反光面17可為光滑面、粗糙面、鍍膜面、遮擋面、或者其他處理方式之表面。稜鏡本體1加工的方式包含研磨、膠合、模造、射出、或者其他加工方式。In an embodiment of the present invention, the material of the
於本發明之一實施例中,第一光線感測器D1及第二光線感測器D2包含光偵測二極體、光偵測二極體陣列、光譜儀、CCD感測器、或者其他感光元件。In one embodiment of the present invention, the first light sensor D1 and the second light sensor D2 include a photodetector diode, a photodetector diode array, a spectrometer, a CCD sensor, or other photosensitive element.
綜上所述,本發明可量測尿糖濃度裝置可同時或者個別檢測光線的折光度與吸光度,結合吸光與折光特性,可對尿液進行尿糖濃度分析,並且無需使用聚光元件作為光源,因而具有簡化光路校正(alignment)的優點。再者,本發明可量測尿糖濃度裝置無需設置透鏡或目鏡等結構,可使整體結構的體積縮小。此外,本發明可量測尿糖濃度裝置無需使用濾片或偏極片等結構,可降低生產成本。再者,本發明可量測尿糖濃度裝置針對尿糖的檢測具有多項優點,包含不須添加化學試劑、不須試紙、透過儀器判讀檢測資訊而降低人為判讀誤差、透過光學檢測而無氧氣與溼氣劣化問題、透過光學檢測可提高檢測頻率以及容易收集測試數據進行統計分析與即時健康管理。In summary, the device for measuring urine sugar concentration of the present invention can detect the refraction and absorbance of light at the same time or individually, and combine light absorption and refraction characteristics to analyze urine sugar concentration without using a light-concentrating element as a light source , thus having the advantage of simplifying the alignment of the optical path. Furthermore, the urine sugar concentration measuring device of the present invention does not need to be provided with structures such as lenses or eyepieces, which can reduce the volume of the overall structure. In addition, the urine sugar concentration measuring device of the present invention does not need to use structures such as filters or polarizers, which can reduce production costs. Furthermore, the urine sugar concentration measuring device of the present invention has many advantages for the detection of urine sugar, including no need to add chemical reagents, no test paper, reduce human interpretation errors through instrument interpretation of detection information, and optical detection without oxygen and The problem of moisture degradation, the detection frequency can be increased through optical detection, and the test data can be easily collected for statistical analysis and real-time health management.
3:可量測尿糖濃度裝置 1:稜鏡本體 10:第一容置空間 11:第一透光面 12:第二透光面 13:第三透光面 14:出光面 15:入光面 16:第一反光面 17:第二反光面 Q:尿液 100:交界面 S1:第一光源 S2:第二光源 L1:第一入射光束 L2:第二射光束 D1:第一光線感測器 D2:第二光線感測器 2:殼體 20:第二容置空間 21:第一出光口 22:第二出光口 23:啟動鍵 24:顯示單元 25:電源鍵 26:外壁 261:穿孔 27:第一容置槽 28:第二容置槽 30:簍空空間 31:輸入單元 32:檢測單元 33:處理單元 θ:預設傾斜角度 θ1:第一夾角 θ2:第二夾角 A,B,C:尿糖特性曲線3: Measuring urine sugar concentration device 1: The main body of 稜鏡 10: The first storage space 11: The first light-transmitting surface 12: The second transparent surface 13: The third transparent surface 14: Light-emitting surface 15: light incident surface 16: The first reflective surface 17: Second reflective surface Q: Urine 100: interface S1: the first light source S2: Second light source L1: first incident beam L2: second beam D1: The first light sensor D2: Second light sensor 2: shell 20: The second storage space 21: The first light outlet 22: Second light outlet 23: start button 24: Display unit 25: Power key 26: outer wall 261: perforation 27: The first storage tank 28: The second storage tank 30: empty space 31: Input unit 32: Detection unit 33: Processing unit θ: preset tilt angle θ1: the first included angle θ2: second included angle A, B, C: urine sugar characteristic curve
圖1A及圖1B係為本發明可量測尿糖濃度裝置的第一立體圖及第二立體圖; 圖2A至圖2D係為本發明可量測尿糖濃度裝置的立體圖、分解圖、上視圖及剖視圖; 圖3A及圖3B係為本發明可量測尿糖濃度裝置的光線反射示意圖及光線穿透液體示意圖; 圖4A至圖4C係為本發明可量測尿糖濃度裝置的反射光線示意圖; 圖5A至圖5D係為本發明第一入射光束入射到可量測尿糖濃度裝置的示意圖; 圖6係為本發明尿液濃度與吸光度的關係示意圖; 圖7係為本發明尿糖濃度與吸光度及折光度的關係示意圖;以及 圖8係為本發明可量測尿糖濃度裝置方塊示意圖。 1A and 1B are the first perspective view and the second perspective view of the device for measuring urine sugar concentration of the present invention; 2A to 2D are perspective views, exploded views, top views and cross-sectional views of the device for measuring urine sugar concentration of the present invention; 3A and 3B are schematic diagrams of light reflection and light penetration through liquid of the device for measuring urine sugar concentration of the present invention; 4A to 4C are schematic diagrams of reflected light of the device for measuring urine sugar concentration of the present invention; 5A to 5D are schematic diagrams of the first incident light beam incident on the device capable of measuring urine sugar concentration according to the present invention; Fig. 6 is a schematic diagram of the relationship between urine concentration and absorbance of the present invention; Figure 7 is a schematic diagram of the relationship between urine sugar concentration, absorbance and refraction in the present invention; and FIG. 8 is a schematic block diagram of a device for measuring urine sugar concentration according to the present invention.
3:可量測尿糖濃度裝置 3: Measuring urine sugar concentration device
1:稜鏡本體 1: The main body of 稜鏡
2:殼體 2: shell
20:第二容置空間 20: The second storage space
21:第一出光口 21: The first light outlet
22:第二出光口 22: Second light outlet
23:啟動鍵 23: start button
24:顯示單元 24: Display unit
25:電源鍵 25: Power key
26:外壁 26: outer wall
261:穿孔 261: perforation
27:第一容置槽 27: The first storage tank
28:第二容置槽 28: The second storage tank
S1:第一光源 S1: the first light source
S2:第二光源 S2: Second light source
D1:第一光線感測器 D1: The first light sensor
D2:第二光線感測器 D2: Second light sensor
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040201835A1 (en) * | 2001-10-11 | 2004-10-14 | John Coates | Low-cost on-line and in-line spectral sensors based on solid-state source and detectors combinations for monitoring lubricants and functional fluids |
TW201506379A (en) * | 2012-02-21 | 2015-02-16 | Entegris Jetalon Solutions Inc | Critical angle optical sensor apparatus |
US20160084759A1 (en) * | 2014-09-24 | 2016-03-24 | Freestone Environmental Services, Inc. | Apparatus for measuring hexavalent chromium in water |
US9500584B2 (en) * | 2011-06-30 | 2016-11-22 | Koninklijke Philips N.V. | Multiple examinations of a sample |
US10209195B2 (en) * | 2015-09-20 | 2019-02-19 | Peirong JIAN | Device for collecting surface-enhanced Raman scattering spectrum using full-aperture-angle parabolic mirror |
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2021
- 2021-11-08 TW TW110141523A patent/TWI792666B/en active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040201835A1 (en) * | 2001-10-11 | 2004-10-14 | John Coates | Low-cost on-line and in-line spectral sensors based on solid-state source and detectors combinations for monitoring lubricants and functional fluids |
US9500584B2 (en) * | 2011-06-30 | 2016-11-22 | Koninklijke Philips N.V. | Multiple examinations of a sample |
TW201506379A (en) * | 2012-02-21 | 2015-02-16 | Entegris Jetalon Solutions Inc | Critical angle optical sensor apparatus |
US20160084759A1 (en) * | 2014-09-24 | 2016-03-24 | Freestone Environmental Services, Inc. | Apparatus for measuring hexavalent chromium in water |
US10209195B2 (en) * | 2015-09-20 | 2019-02-19 | Peirong JIAN | Device for collecting surface-enhanced Raman scattering spectrum using full-aperture-angle parabolic mirror |
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