TWI786836B - Anti-blue light contact lens and material and method for manufacturing the same - Google Patents

Abstract

The present invention provides an anti-blue light and anti-UV contact lens and its manufacturing material and process. The copolymerized mixture is composed of linear silicon-containing prepolymer monomers, hydrophilic monomers, UV absorbers and silver ion-containing solvents. By starting and completing the free radical chain polymerization and cross-linking reaction by blue light, a lens body can be formed after the material curing process. The present invention does not need to add additional reducing agent and dispersant, and may reduce silver ions into nano-metal silver particles through redox reaction in-situ. In this way, the silver/silicon composite nano-particles in the silicon-containing spectacle lens material can be uniformly distributed without affecting the photopolymerization process, and a very small amount of silver ion concentration may achieve the effect of anti-blue light. The copolymerization of anti-UV reactive monomers may make contact lenses with anti-blue light and anti-UV high oxygen permeable silicone hydrogel at one time.

Description

Anti-blue light contact lens and manufacturing material and method thereof

The present invention relates to silicone hydrogel lenses, in particular to a manufacturing method, material and finished product of contact lenses capable of resisting blue light.

Contact lenses have been commercialized for 70 years since they were invented in early 1950. The initial contact lenses were made of hard materials (such as: PMMA polymethyl methacrylate). The oxygen permeability and hydrophilicity of the main body are not good, so that the wearable time of the contact lens is short, and there will be obvious foreign body discomfort. The invention of soft contact lenses in the mid-1970s can be described as a progressive reform, which is made of a HEMA (2-hydroxyethyl methyl acrylate)-based water-gel material. Due to the high water absorption of this material, after hydration, it becomes soft and highly water-containing, which greatly improves the wearing comfort. However, its oxygen permeability is still low, and it can only be worn for 8 to 12 hours a day. Later, corneal hypoxic edema and neovascularization often occur. In the early 1980s, although there was a product with high oxygen permeability hard contact lens, which had a super high oxygen permeability, but because of the hard material, the foreign body discomfort caused by wearing it on the eyeball still could not be improved, so that it could not be widely used into consumer acceptance. It can be seen from the above that contact lenses have always had the requirements of high oxygen permeability, high comfort and long-term wearability. After continuous improvement in the contact lens industry, the development of soft silicone hydrogel with high oxygen permeability has finally become the mainstream.

With the increasing penetration rate and usage time of various 3C products such as LCD TVs, tablet computers and smart phones, the problem of blue light hazards has gradually attracted people's attention. It is generally believed that blue light can increase macular degeneration and For the risk of retinopathy, the wavelength of visible light in both eyes is 380-780nm, and the wavelength of light that increases eye glare and fatigue is short-wave blue light in the range of 381-460nm. Excessive blue light will cause eye damage. Blue light will penetrate the lens, vitreous body and reach the macula and retina, causing light damage to the eyes. In addition, when blue light enters the eyes, a large number of free radicals will be generated, which will damage the unsaturated fatty acids in the retina. In the initial stage of excessive blue light damage, the eyes will be more sensitive to light, with symptoms such as tingling and photophobia; if the excessive blue light damage is not immediately improved at this time , Inflammation and edema of the macula. Once a hidden node is formed in the macular area, when the hidden node ruptures, hemorrhage will occur, which will cause central vision loss. In short, excess blue light can cause cataracts and even macular degeneration. Blue light hinders sleep by delaying or stopping the brain's production of melatonin, making it more difficult to fall asleep. Generally speaking, the human crystal can filter 30% to 50% of the blue light in the light, and the human body still needs an appropriate amount of blue light to maintain visual and psychological functions. Moderate blue light makes the color of objects and vision brighter, making people feel more happy; on the contrary, if too much blue light is filtered, it is easy to make people feel depressed, anxious, and even melancholy. A filter value of 30% can achieve the effect of filtering blue light. In view of the aforementioned problems, more and more people are beginning to wear anti-blue light glasses to reduce the harm of blue light (blue-violet light) to the eyes. At present, most of the anti-blue light frame glasses add yellow dye or surface coating to the lenses to change the The color of the lens, and then the lens can filter out blue light. However, most contact lenses cannot use the above-mentioned manufacturing method, especially for silicone hydrogel contact lenses, there are many obstacles and complexities. Therefore, how to provide users with better anti-blue light contact lens products has become an important topic to be discussed in the present invention.

The anti-blue light contact lens commonly known in the market is like the anti-blue light and anti-UV contact lens disclosed in the Republic of China Patent No. M487455 "Colored Contact Lens with Blue Light Filter and Anti-UV Function", which consists of upper, middle and lower lenses. , and use the blue light filter coating agent in the upper lens to achieve the effect of reducing the blue light penetrating contact lenses and direct eyes. Among them, the blue light filter coating agent is currently not legally added to the US FDA safety approval scope of contact lenses, and will cause harm Eyes are worried, and there is no efficiency in mass production except time-consuming, labor-consuming and cost-consuming.

Patent No. I554803 of the Republic of China discloses a manufacturing method that can simplify the manufacturing process and consistently produce anti-blue light contact lenses with anti-blue light and anti-ultraviolet rays. It is to adjust one or more yellow, orange, red, green and other dyes according to the color of the dye and the addition ratio, or add the blue light absorber to the contact lens hydrogel or silicon hydrogel monomer, and then carry out molding or Rotary molding and other processes, after the dry film is cured and formed, throw it into the hydration tank for color fixation and hydration extraction to complete the finished anti-blue light contact lens. However, this invention is not suitable for high-concentration dyes, because it also blocks the initial reaction of UV-visible light (wavelength 380-400nm) and cannot be polymerized to form lenses.

Patent No. I725719 of the Republic of China discloses another spectacle lens material for anti-blue light, spectacle lens and its manufacturing process, wherein the spectacle lens material can be used to produce the required spectacle lens, which at least includes silver/silicon oxide composite A mixture of nanoparticles and at least one kind of macromolecular monomer, each of which can form a body after a material solidification process. The most advanced analysis of the invention is to add a reducing agent solution to reduce it to nano silver Afterwards, after being centrifuged and concentrated, it is redissolved in the reaction monomer, and finally the mixture is irradiated with ultraviolet light (UV), so that the polymer monomer and the photoinitiator are crosslinked by ultraviolet light (UV), and can be cured (or polymerization) to form the bulk mixture containing the silver/silicon oxide composite nanoparticles. The above process is extremely cumbersome, and the nano-silver complex cannot avoid re-aggregation after centrifugation and concentration, which affects its dispersion. Therefore, to a certain extent, it will affect the photopolymerization reactivity, which will cause changes in the structure or specifications of the lens body.

At present, the general public does not have a deep understanding of nano-silver. Because they do not understand, it is easy to generate some false rumors or misunderstandings. Among them, nano-silver is banned by the European Union and the United States, which is one of the most misunderstandings. Nano-silver is in the EU. And the United States has not banned the use and sale of nano-silver, and there are many cosmetics and daily products that add nano-silver in the US and EU markets. Furthermore, under normal use, the nano-silver aqueous solution will not penetrate the dermis of the skin, nor will it penetrate the epithelial cell layer of the nasal mucosa. The nano-silver aqueous solution has been certified and will not cause irritation and allergic reactions to the skin and eyes. Because nano silver has quite good antibacterial activity, it is often used as a raw material and applied in industry. It is used in daily necessities and medical care products, including anti-fouling layer applied on the surface of washing machine, pure water purification, toys, surgery, etc. Surgical tools, etc. In addition, its special optical properties are gradually being widely used in optical materials. The principle is that silver nanoparticles have Surface Plasmon Resonance (SPR) effect on light waves (ultraviolet, visible, and near-infrared ranges). Since silver has many free electrons, these electrons are easy to move with the external electromagnetic field, and gradually form a shielding effect from the outside to the inside, so that the internal electrons cannot feel the change of the external electromagnetic field; but when gold or silver particles When the diameter is small enough (less than 200 nm), all the free electrons in the entire metal particle move collectively, which will cause great absorption and scattering of incident light waves. This phenomenon is called the surface plasmon resonance effect. The synthesized solution containing silver nanoparticles is yellow because surface plasmon resonance causes silver nanoparticles to absorb and scatter blue light at 420 nm, so that when white light is transmitted through the solution, only the main light waves (red and green) pass through. Transparent, the old man's vision presents a yellow effect. Therefore, anti-blue light contact lenses can be developed by utilizing its blue light filtering properties.

The invention provides a method for manufacturing an anti-blue light contact lens. The steps include synthesizing a polysiloxane prepolymer, wherein the polysiloxane prepolymer contains polyethylene glycol; dissolving the silver ion compound in a non-aqueous solvent, and Prepare a silver ion solution; mix the silver ion solution with the polysiloxane prepolymer, so that the silver ions in the silver ion solution are uniformly distributed in the polysiloxane prepolymer; the hydrophilic monomer and a photosensitive initiator is added to the polysiloxane prepolymer and mixed to form a silicone hydrogel composition; and the silicone hydrogel composition is irradiated with blue light to simultaneously perform a cross-linking curing reaction and a silver ion reduction reaction, A silicone hydrogel lens with anti-blue light nano-silver is formed.

In the above silicone hydrogel composition, silicon-containing monomers and polysiloxane prepolymers can be added to mix at the same time. The content of polysiloxane prepolymers plus silicon-containing monomers is 30~80wt%, and the hydrophilicity The content of the repeating unit of the monomer is 10-50wt%, the content of the photosensitive initiator is 0.1-2wt%, and the content of the silver ion compound is 10-200ppm.

The following method can be used to synthesize the amphoteric silicon-containing prepolymer: a bishydroxy polydimethylsiloxane compound and an isocyanate compound are used as raw materials, and then a diluent is added to react in a medium-temperature environment to Obtain a first product; add the first product to a hydrophilic chain extender, sequentially carry out terminal hydroxylation reaction, and then chain extension reaction to obtain a second product; combine the second product and an acrylate compound in Continue to react at room temperature for at least 12 hours to obtain an amphoteric silicon-containing prepolymer; the hydrophilic chain extender is mainly polyol series, which can include ethylene glycol, propylene glycol, 1,4 butanediol, polyethylene glycol, polyol Propylene glycol, polypropylene glycol diglycidyl ether, etc.

The above silicon hydrogel composition may further include 10-20wt% diluent.

The aforementioned silicon-containing monomers can be 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS), 3-acryloxypropyl tris(trimethylsiloxy)silane, TRIS, 3-acryloxypropyl tri(trimethylsiloxy)silane), 3-acrylamidopropyl tris(trimethylsiloxy)silane, 3-methacrylamide Amidopropyltris(trimethylsiloxy)silane, (3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane, SiGMA), A monofunctional polydimethylsiloxane polymer (monofunctional Polydimethylsiloxane, mPDMS) or a combination thereof with a number average molecular weight of 657 to 1500.

The hydrophilic monomer can be 2-hydroxyethyl methacrylate (2-hydroxyethyl methacrylate, HEMA); N, N-dimethyl acrylamide (N, N-dimethyl acrylamide, DMA), N, N-dimethacrylate Ethyl acrylamide (N, N-diethyl acrylamide, DEA), N-vinyl pyrrolidone (N-vinyl pyrrolidone, NVP), glycerol methacrylate (glycerol methacrylate, GMA), polyethylene glycol with a molecular weight of 400 Polyethylene glycol methacrylate mono methyl ether or combinations thereof.

When mixing the above silicon hydrogel composition, UV-blocking monomers can be added at the same time, wherein the content of UV-blocking monomers is 0.1-1.5wt%. The UV-blocking monomer may be a monomer having benzotriazole.

The present invention also provides a material for manufacturing anti-blue light spectacle lenses, which includes the above silicon hydrogel composition.

The present invention also provides an anti-blue light spectacle lens made by the aforementioned method.

The purpose of the present invention is to provide a spectacle lens material for anti-blue light, which can be used to make spectacle lenses, wherein the spectacle lens material at least includes polysiloxane prepolymer, silver ion solution and at least one hydrophilic A mixture composed of high molecular monomers, the mixture can form a body after a material solidification process, and the silver/silicon composite nanoparticles are mixed in the body, when the particle size of silver is 1 nanometer (nm) to At 100nm, it can absorb blue light with a wavelength of 400nm to 500nm. Therefore, silver/silicon composite nanoparticles can absorb blue light with greater energy in the visible light that penetrates the lens of the glasses. , in order to achieve the purpose of anti-blue light, so the polysiloxane prepolymer can be regarded as a nano-silver protective agent or dispersant, and can also be used as a cross-linking agent for bulk polymerization. Among them, the polyethylene glycol (Polyethylene Glycols, PEG) in the polysiloxane prepolymer stabilizes the nanoparticles through the structural method, and has a strong bonding ability with the center and is not easy to dissociate into ions. Reduction of silver ions through blue light can form uniformly distributed nano-silver particles in the body without adding any additional reducing agent. Most importantly, this process is in-situ formation (in-situ) without affecting the degree of photopolymerization, so the strength of the lens can be maintained and integrity to meet contact lens comfort-wearing specifications. This is different from other production principles of anti-blue light contact lenses, which are first reduced to metal nanoparticles and then added to the reaction monomer, so the use of photopolymerization will be greatly troubled. Because the initial wavelength of ultraviolet light is between 360 and 420nm, the metal nanoparticles will absorb or scatter the wavelength band, resulting in insufficient initial energy and uniformity, which will greatly affect the integrity and strength of the lens body, that is, it will Distorting and deforming the lens affects the effectiveness of vision correction as well as wearing comfort and safety.

＜Synthesis of polysiloxane prepolymer＞

To provide a method for preparing an amphoteric silicon-containing prepolymer, which is obtained by reacting isocyanic acid with polydimethylsiloxane compound as a raw material, and then capping with a hydroxyl monomer, which includes the following Steps: Isocyanic acid reaction: use a bishydroxy polydimethylsiloxane compound and an isocyanic acid compound as raw materials, and then add a diluent to react in a medium temperature environment to obtain a first formation product; the first product is added to a hydrophilic chain extender (chain extender), and the terminal hydroxylation reaction is carried out in turn, and then the chain extension reaction is obtained to obtain a second product: the second product and an acrylate compound Continue the reaction at room temperature for at least 12 hours to obtain an amphoteric silicon-containing prepolymer as the third product. Among them, the hydrophilic chain extenders are mainly polyol series, including ethylene glycol, propylene glycol, 1,4 butanediol, polyethylene glycol, polypropylene glycol, polypropylene glycol diglycidyl ether, etc.

Its detailed example is as follows: take 50g of dimethyl polysiloxane containing double-terminal hydroxyl groups (trade name KF-6001, purchased from Zixinyue Chemical Industry Co., Ltd.), add 10g of isofluorine under nitrogen at room temperature ketone diisocyanate and 0.02g dibutyltin dilaurate, after reacting for 12 hours, add 30g polyethylene glycol (weight average molecular weight is 600), 100g tetrahydrofuran and 0.02g dibutyltin dilaurate, react for 24 hours again, with Infrared absorption spectrum confirms that the characteristic peak of -NCO at around 2250 cm-1 disappears and the reaction is completed. Add 10g of isophorone diisocyanate and 0.02g of dibutyltin dilaurate at room temperature under nitrogen again, and after 24 hours of reaction, add 12g of 2-methyl-2-acrylic acid-2,3-dihydroxypropyl Esters, 0.02g of dibutyltin dilaurate, reacted at 60°C for 24 hours, confirmed by infrared absorption spectrum that the -NCO characteristic peak at around 2250cm-1 disappeared and the reaction was completed, and polysiloxane with dimethylpolysiloxane as the main structure was obtained. The oxane prepolymer has a weight average molecular weight of 11,000~13,000 (identified by GPC).

＜Hydrophilic copolymer composition＞

The invention provides a hydrophilic copolymer composition, which comprises polysiloxane prepolymer, single-end acrylic silane and hydrophilic monomer. The hydrophilic monomer can be but not limited to N,N-dimethylacrylamide (referred to as DMA, available from TCI Company), N-vinylpyrrolidone (abbreviated as NVP, available from ALDRICH Company), methacrylic acid -2-hydroxyethyl ester (abbreviated as HEMA, available from TCI Company) or ethylene glycol dimethacrylate (abbreviated as EGDMA, available from BASF Company). In addition, the hydrophilic monomers may be used alone or in combination of two or more.

The aforementioned hydrophilic copolymer composition may further include a diluent and a photoinitiator. The diluent can increase the miscibility, and the content of the diluent can be 0 to 25 weight percent. The diluent can be but not limited to isopropanol (IPA for short). In addition, diluents may be used alone or in combination of two or more. The photosensitive initiator is beneficial to UV light curing, and the content of the photosensitive initiator may be 0.1 weight percent to 2 weight percent. The photoinitiator can be but not limited to the trade name Ciba®IRGACURE®1173, referred to as I-1173, and the trade name Ciba®IRGACURE®819), referred to as I-819. In addition, photoinitiators may be used alone or in combination of two or more (including two). The aforementioned hydrophilic copolymer composition may optionally further include other additives to meet actual needs, and the additives that may be used include but are not limited to anti-UV absorbers and leveling agents.

＜Silver ion solution＞

Inorganic silver salts are the most common silver ion compounds, and the more common ones are silver nitrate, silver acetate and silver thiosulfate. Dissolve the silver ion compound in a non-aqueous solvent, usually methanol (Methanol), ethanol (Ethanol), propanol (Propanol, molecular formula is C ₃ H ₇ OH), isopropanol (molecular formula is C ₃ H ₈ O ), butanol (Butanol, molecular formula C ₄ H ₉ OH) or ethylene glycol (ethylene glycol), etc.

The present invention is a spectacle lens material for anti-blue light, spectacle lens and its manufacturing process. In one embodiment, the spectacle lens can be used as a lens of contact lenses or general external glasses.

In an embodiment of the present invention, the silicon-containing monomer that can be freely selected in addition to the polysiloxane prepolymer includes 3-methacryloxypropyl tris(trimethylsiloxy)silane (3-methacryloxypropyl tris(tirmethylsiloxy)silane, TRIS), 3-acryloxypropyl tri(trimethylsiloxy)silane (3-acryloxypropyl tri(trimethylsiloxy)silane), 3-acrylamidopropyl tri(trimethylsilane) Oxy)silane (3-acrylamidopropyl tris(trimethylsiloxy)silane), 3-methacrylamidopropyl tris(trimethylsiloxy)silane, (3-methacrylamideoxy-2-hydroxypropoxy base) propylbis(trimethylsiloxy)methylsilane, SiGMA), monofunctional polydimethylsiloxane polymer (monofunctional Polydimethylsiloxane, mPDMS) with a number average molecular weight of 657 to 1500, and combinations thereof the group formed;

In an embodiment of the present invention, the above-mentioned first hydrophilic monomer is selected from 2-hydroxyethyl methacrylate (2-hydroxyethyl methacrylate, HEMA); N,N-dimethylacrylamide (N,N-dimethyl acrylamide, DMA), N, N-diethyl acrylamide (N, N-diethyl acrylamide, DEA), N-vinyl pyrrolidone (N-vinyl pyrrolidone, NVP), glycerol methacrylate (glycerol methacrylate, GMA), polyethylene glycol methacrylate monomethyl ether with a molecular weight of 400 (polyethylene glycol methacrylate mono methyl ether) and a group consisting of combinations thereof.

According to an embodiment of the present invention, the above-mentioned derivatized silicon-containing monomers include polysiloxane prepolymers in an amount of 30-80 wt%, and the repeating units of hydrophilic monomers in an amount of 10-50 wt%, The diluent accounts for 10-20 wt% of the whole weight, and the UV-blocking monomer is a monomer containing benzotriazole. According to the embodiment of the present invention, the content of UV-blocking monomer accounts for 0.1~1.5wt% of the total weight of the silicon hydrogel composition; in addition, the photoinitiator accounts for 0.1~2wt% of the overall weight, and the silver ion compound accounts for 10~10wt% of the overall weight. 200 ppm.

According to one of the embodiments of the present invention, there is provided a method for preparing an anti-blue light silicon hydrogel contact lens containing nano-silver.

First, in the diluent, add the silver ion compound and stir for about 0.5 hours to 1.5 hours, and keep the temperature of the silver ion solution at room temperature (20-40 degrees Celsius to completely dissolve it, first add polysiloxane to pre- After the polymer is stirred for about 0.5 hours to 1.5 hours, the silicon-containing monomer/hydrophilic monomer/initiator and the UV-blocking monomer can be added together. After stirring for about 0.5 hours to 1.5 hours, the silicon of the present invention can be formed. Hydrogel composition. One aspect of the present invention provides a method for manufacturing the above-mentioned silicon hydrogel lens. The silicon hydrogel composition of any of the above-mentioned embodiments or examples is injected into the mold for preparing the lens; The hydrogel composition is subjected to photocuring treatment for 30 to 60 minutes to allow it to undergo a cross-linking and curing reaction to form a silicone hydrogel lens; the above-mentioned silicone hydrogel lens is extracted with a liquid containing water to remove the parts that have not undergone a cross-linking and curing reaction. Silicon high polymer; put the above silicon hydrogel lens into phosphoric acid or boric acid saline buffer solution with a pH value of 7.1~7.5 for high temperature and high pressure sterilization.

In the following examples, various parameters of the silicon hydrogel lenses manufactured by the above manufacturing method were tested according to the international standard ISO 18369, including water content, light refractive index, visible light transmittance, anti-blue light transmittance and transmittance Oxygen rate detection, including lens strength and elastic coefficient, etc. All commercially available silicon hydrogel lens specifications have the following characteristics: visible light transmittance must be greater than 89%, water content must be 24 to 74%, oxygen transmission rate is 45 to 140DK, tensile strength is greater than 1MPa, and elastic coefficient is between 0.4 and 1.2 Between; the elongation (%) is more than 50%.

According to above-mentioned implementation mode, following embodiment is arranged

Example 1

Dissolve 0.001, 0.005, 0.01 and 0.02g (codenamed SHy, SAg10, SAg50, SAg100 and SAg200) of silver nitrate in 20g of IPA and stir for 1 hour at room temperature, add 50g of siloxane prepolymer and stir for 1 hour at room temperature, then add 10g of TRIS /30g DMA)/1g 2-(2'-hydroxy-5-methacrylyloxyethylphenyl)-2H-benzotriazole, HMEPB/0.8g I819 and stirred at room temperature for 1 hour to complete the silver/silicon hydrocolloid combined solution. This solution is injected into the mold for blue light curing for 60 minutes to form a silicon hydrogel dry film. After swelling and washing with alcohol and aqueous solution at room temperature, it was placed in phosphate buffer solution and sterilized at 121°C for 30 minutes. This completes the anti-blue light/anti-UV silicone hydrogel contact lenses. The results of the examples are listed in the following table

Table 1 SHy SAg10 SAg50 SAg100 SAg200 Refractive index/water content% 1.400/52.6 1.398/56.3 1.395/58.6 1.393/62.6 1.390/62.4 Oxygen transmission rate (DK, barrers) 75.0 78.6 82.5 82.4 83.3 Tensile strength (MPa) 1.6 1.2 1.2 1.0 0.7 Elastic coefficient (Mpa) 0.65 0.61 0.51 0.48 0.47 Elongation (%) 85.2 86.3 88.5 75.3 57.1

It can be seen from Table 1 that the physical properties of the lenses produced in each embodiment are not very different, which shows that the physical properties of the lenses produced by the method of the present invention meet the standard requirements for contact lenses.

Table 2 SHy SAg10ppm SAg50 SAg100 SAg200 Visible light transmittance ^a % 96.2 93.5 92.7 90.5 88.2 Blue light transmittance/blocking rate ^b % 94.2/5.8 81.6/18.4 74.8/25.2 57.9/42.1 45.8/55.2 UVA transmittance/blocking ^ratec % 92.3/7.7 5.2/94.2 3.2/96.8 2.0/98.0 1.2/98.8 UVB transmittance/blocking rate ^d % 78.8/21.2 0.1/99.9 0.1/99.9 0.1/99.9 0.1/99.9 a means the wavelength is 380~780 nm b means the wavelength is 380~460 nm c means the wavelength is 316~380 nm d means the wavelength is 281~315 nm

The results of the examples are further analyzed below.

The color of the contact lenses produced in this example gradually changes from light yellow to light yellow with the increase of silver ions, but the color still does not become dark yellow at 200ppm so as to affect the appearance and wearability. The SPR effect also proves that the body is Nai The rice silver is evenly distributed.

From Table 1, when the concentration of silver ions increases from 10ppm to 200ppm, the refractive index gradually decreases and the water content gradually increases, but the change is not obvious, which shows that nano-silver will still block the initial energy of light, affect the degree of photopolymerization, and make the bulk The structure is relatively loose, which leads to the increase of water content, which reduces the strength and elongation. However, in the presence of the maximum amount of 200ppm silver ions, it is only about 10% lower than that of the reference substance (SAg) and the appearance of the lens is not distorted or deformed. Its geometric properties such as lens diameter, radius of curvature and center thickness are not significantly different from those of the comparison product. In addition, different silver ion concentrations have no significant difference in the oxygen transmission rate, and can reach about 80Dk, combined with a water content of more than 50%, which shows that it has superior characteristics of silicon hydrogel contact lenses.

Table 2 and Figure 1 show the changes in the optical properties of the lenses produced in the examples. When the UV absorber is added, the anti-UV ability will be significantly increased, and both can reach Class I (UVA > 90%, UVB > 99%). When silver When the ion concentration is 10ppm, it has about 20% anti-blue light ability, which shows that this process has an excellent reduction ability to silver ions, and its visible light transmittance can be above 90%, which shows that it does not affect vision correction. The presence of silver at 200ppm can achieve about 50% anti-blue light ability, which shows that nano-silver has a very high correlation with the blue light blocking rate.

FIG. 1 is a comparison chart of the changes in the optical properties of the lenses produced in the examples of the present invention.

Claims (10)

A method for manufacturing an anti-blue light contact lens, comprising the following steps: a. synthesizing a polysiloxane prepolymer, wherein the polysiloxane prepolymer contains polyethylene glycol; b. dissolving the silver ion compound in non- In an aqueous solvent, to prepare a silver ion solution; c. mix the silver ion solution with the polysiloxane prepolymer, so that the silver ions in the silver ion solution are evenly distributed in the polysiloxane prepolymer middle; d. adding hydrophilic monomers and photoinitiators to the polysiloxane prepolymer and mixing to form a silicone hydrogel composition; and e. irradiating the silicone hydrogel composition with blue light to simultaneously Carry out cross-linking curing reaction and silver ion reduction reaction to form silicon hydrogel lenses with anti-blue light nano-silver. The method as described in claim 1, wherein in the silicone hydrogel composition in the step d, a silicon-containing monomer can be added to mix with the polysiloxane prepolymer at the same time, and the polysiloxane prepolymer In addition, the content of the silicon-containing monomer is 30-80wt%, the content of the repeating unit of the hydrophilic monomer is 10-50wt%, the content of the photosensitive initiator is 0.1-2wt%, and the content of the silver ion compound is 10~200ppm. The method as described in claim 1, wherein the synthesis of the polysiloxane prepolymer in this step includes the following steps: using a bishydroxy polydimethylsiloxane compound and an isocyanate compound as raw materials, Then add a diluent and react in a medium temperature environment to obtain a first product; add a hydrophilic chain extender to the first product, carry out terminal hydroxylation reaction in turn, and then chain extension reaction to obtain a first product The second product; continue to react the second product with an acrylate compound at room temperature for at least 12 hours to obtain an amphoteric silicon-containing prepolymer; wherein the hydrophilic chain extender is selected from ethylene glycol, propylene glycol, 1 , A group consisting of 4 butanediol, polyethylene glycol, polypropylene glycol, polypropylene glycol diglycidyl ether and combinations thereof. The method as described in claim 1, wherein the silicone hydrogel composition further includes 10-20wt% diluent. The method as described in claim 2, wherein the silicon-containing monomer is selected from the group consisting of 3-methacryloxypropyl tris(tirmethylsiloxy)silane (TRIS), 3 -Acryloxypropyltris(trimethylsiloxy)silane (3-acryloxypropyl tri(trimethylsiloxy)silane), 3-acrylamidopropyl tris(trimethylsiloxy)silane (3-acrylamidopropyl tris(trimethylsiloxy)silane), 3-methacrylamidopropyl tri( Trimethylsiloxy)silane, (3-methacryloxy-2-hydroxypropoxy)propylbis(trimethylsiloxy)methylsilane, SiGMA), number average molecular weight of 657 to A group consisting of 1500 monofunctional polydimethylsiloxane polymers (monofunctional Polydimethylsiloxane, mPDMS) and combinations thereof. The method as described in claim item 1, wherein the hydrophilic monomer is selected from 2-hydroxyethyl methacrylate (2-hydroxyethyl methacrylate, HEMA); N,N-dimethylacrylamide (N,N- dimethyl acrylamide, DMA), N, N-diethyl acrylamide (N, N-diethyl acrylamide, DEA), N-vinyl pyrrolidone (N-vinyl pyrrolidone, NVP), glycerol methacrylate , GMA), polyethylene glycol methacrylate monomethyl ether with a molecular weight of 400 (polyethylene glycol methacrylate mono methyl ether) and a group consisting of combinations thereof. In the method described in Claim 1, a UV-blocking monomer is added simultaneously in the step d, wherein the content of the UV-blocking monomer is 0.1-1.5 wt%. The method according to claim 7, wherein the UV-blocking monomer is a monomer having benzotriazole. A material for manufacturing anti-blue light spectacle lenses, comprising the silicon hydrogel composition in the method described in claims 1 to 8. An anti-blue light spectacle lens is made by the method described in claims 1 to 8.

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