TWI762077B - Uric acid detection device - Google Patents
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Abstract
本發明提供一種尿酸檢測裝置,主要包括一殼體、一發光單元、一光感測器及一處理器。殼體包括彼此連接的檢測部與握持部。處理器容置握持部,且電性連接發光單元及光感測器。檢測部相應於一液體通道的相對兩內表面分別設有發光單元與光感測器,處理器驅動發光單元產生一發射光源,其中發射光源的波長介於200至450nm。發射光源用以投射在一待測溶液上,並產生一檢測光源。光感測器用以接收檢測光源,並將檢測光源轉換為一檢測訊號。處理器由光感測器接收檢測訊號,並判斷檢測光源的290nm的吸收率是否大於260nm的吸收率,以判斷檢測溶液是否含有尿酸。 The invention provides a uric acid detection device, which mainly includes a casing, a light-emitting unit, a light sensor and a processor. The housing includes a detection portion and a grip portion connected to each other. The processor accommodates the holding portion, and is electrically connected to the light-emitting unit and the light sensor. The detection part is respectively provided with a light-emitting unit and a light sensor corresponding to two opposite inner surfaces of a liquid channel. The processor drives the light-emitting unit to generate an emission light source, wherein the wavelength of the emission light source is between 200 and 450 nm. The emission light source is used for projecting on a solution to be tested, and a detection light source is generated. The light sensor is used for receiving the detection light source and converting the detection light source into a detection signal. The processor receives the detection signal from the light sensor, and determines whether the absorption rate at 290 nm of the detection light source is greater than the absorption rate at 260 nm, so as to determine whether the detection solution contains uric acid.
Description
本發明有關於一種尿酸檢測裝置,可快速檢測出待測溶液中是否含有尿酸。 The invention relates to a uric acid detection device, which can quickly detect whether a solution to be tested contains uric acid.
因為飲食習慣的改變,高尿酸血症已然成為現代人常見的文明病之一。根據醫學研究報告,高尿酸血症除會導致痛風外,也可能會引起肥胖、高血脂、糖尿病、心臟病及腦血管病變等慢性疾病。 Due to changes in eating habits, hyperuricemia has become one of the common civilization diseases of modern people. According to medical research reports, in addition to gout, hyperuricemia may also cause chronic diseases such as obesity, hyperlipidemia, diabetes, heart disease and cerebrovascular disease.
尿酸是體內普林代謝的最終產物,一般而言,男性的每100毫升血液中的尿酸值在7毫克以上,女生在6毫克以上時,便稱為高尿酸血症。透過尿酸的檢測,能夠得知個人的即時健康狀況,並可立即調整飲食,以減緩血液中尿酸含量持續增加,並降低痛風發生的機率。 Uric acid is the final product of purine metabolism in the body. Generally speaking, the uric acid value per 100 ml of blood in men is above 7 mg, and when it is above 6 mg in girls, it is called hyperuricemia. Through the detection of uric acid, the real-time health status of an individual can be known, and the diet can be adjusted immediately to slow down the continuous increase of uric acid in the blood and reduce the probability of gout.
目前常見的尿酸檢測方式以抽血檢測及尿液檢測為主,抽血檢測前待測者須空腹8-10小時,並需要至醫院或醫療中心使用化學試劑搭配光電分析,才能檢測出血液的尿酸濃度。尿液檢測則需要待測者採集24小時內的尿液,並同樣需要至醫院或醫療中心進行檢測。 At present, the common uric acid detection methods are mainly blood test and urine test. Before blood test, the person to be tested must fast for 8-10 hours, and need to go to the hospital or medical center to use chemical reagents and photoelectric analysis to detect blood. Uric acid concentration. Urine testing requires the person to be tested to collect urine within 24 hours, and also needs to go to a hospital or medical center for testing.
上述兩種傳統的尿酸檢測都缺乏即時性,因此大部分的人都只有在痛風發作的時候才意識到自己的尿酸過高,此時只能服用藥物代謝血液中的尿酸。 The two traditional uric acid tests mentioned above lack immediateness, so most people only realize that their uric acid is too high when they have a gout attack. At this time, they can only take drugs to metabolize uric acid in the blood.
為了解決上述先前技術面臨的問題,本發明提出一種尿酸檢測裝置,可即時得知待測者尿液中的尿酸是否過高,並即時調整飲食,進而推論血液中的尿酸是否過高,並即時調整飲食,以降低痛風發生的機率。 In order to solve the problems faced by the above-mentioned prior art, the present invention proposes a uric acid detection device, which can instantly know whether the uric acid in the urine of the test subject is too high, adjust the diet in real time, and then infer whether the uric acid in the blood is too high, and immediately Adjust your diet to reduce your chances of developing gout.
本發明的一目的,在於提供一種尿酸檢測裝置,主要包括一殼體、一發光單元、一光感測器及一處理器。殼體包括彼此連接的檢測部與握持部。處理器容置握持部,且電性連接發光單元及光感測單元。檢測部相應於一液體通道的相對兩內表面分別設有發光單元與光感測器,發光單元用以產生波長介於200至450nm的發射光源,其中發射光源用以投射在一待測溶液上,以產生一檢測光源(吸收光源)。光感測器用以接收檢測光源,並將檢測光源轉換為一檢測訊號。處理器由光感測器接收檢測訊號,並由檢測訊號中290nm與260nm的部分,來判斷待測溶液中的尿酸是否過高。 An object of the present invention is to provide a uric acid detection device, which mainly includes a casing, a light-emitting unit, a light sensor and a processor. The housing includes a detection portion and a grip portion connected to each other. The processor accommodates the holding portion and is electrically connected to the light-emitting unit and the light-sensing unit. The detection part is respectively provided with a light-emitting unit and a light sensor corresponding to two opposite inner surfaces of a liquid channel. The light-emitting unit is used to generate an emission light source with a wavelength of 200 to 450 nm, wherein the emission light source is used to project a solution to be tested. , to generate a detection light source (absorption light source). The light sensor is used for receiving the detection light source and converting the detection light source into a detection signal. The processor receives the detection signal from the light sensor, and determines whether the uric acid in the solution to be tested is too high from the 290nm and 260nm parts of the detection signal.
根據本發明的實施例,處理器判斷待測溶液中的尿酸是否過高的方式為:由檢測訊號判斷該檢測光源的290nm的吸收率是否大於260nm的吸收率;由檢測訊號判斷該檢測光源的290nm的吸收率與260nm的吸收率之比值是否大於一特定比值;由檢測訊號判斷該檢測光源的290nm的吸收率減去260nm的吸收率的差異值是否大於一特定差異值;由檢測訊號判斷檢測光源的290nm的吸收率與260nm的吸收率的斜率是來判斷;或由該檢測訊號判斷該檢測光源的290nm的吸收率與260nm的吸收率的絕對值,透過對由不同的絕對值大小分布範圍建立一個查找表(Look-up table)進行查找,以判斷尿酸是否過高。 According to the embodiment of the present invention, the way for the processor to determine whether the uric acid in the solution to be tested is too high is as follows: determine whether the absorption rate of the detection light source at 290 nm is greater than the absorption rate of 260 nm by the detection signal; determine the absorption rate of the detection light source by the detection signal Whether the ratio of the absorptivity at 290nm to the absorptivity at 260nm is greater than a specific ratio; determine whether the difference between the absorbance at 290nm minus the absorbance at 260nm of the detection light source is greater than a specific difference value from the detection signal; The 290nm absorptivity and the 260nm absorptivity slope of the light source are judged; or the absolute value of the 290nm absorptivity and 260nm absorptivity of the detection light source can be judged from the detection signal. Build a look-up table to find out whether uric acid is too high.
根據本發明的實施例,處理器更由檢測訊號推算出檢測光源中的290nm及260nm的吸收率,並由290nm及260nm的吸收率推算出待測溶液中的尿酸含量。 According to an embodiment of the present invention, the processor further calculates the absorbance at 290 nm and 260 nm in the detection light source from the detection signal, and calculates the uric acid content in the solution to be tested from the absorbance at 290 nm and 260 nm.
根據本發明的實施例,尿酸檢測裝置更包括一反射單元用以反射檢測光源,而光感測器則接收經過反射單元反射的檢測光源。 According to an embodiment of the present invention, the uric acid detection device further includes a reflection unit for reflecting the detection light source, and the light sensor receives the detection light source reflected by the reflection unit.
根據本發明的實施例,尿酸檢測裝置更包括包括一顯示單元電性連接該處理器,並用以顯示該待測溶液是否含有尿酸。 According to an embodiment of the present invention, the uric acid detection device further includes a display unit electrically connected to the processor for displaying whether the solution to be tested contains uric acid.
根據本發明的實施例,尿酸檢測裝置更包括至少一控制介面電性連接處理器及發光單元,並用以控制或啟動處理器及發光單元。 According to an embodiment of the present invention, the uric acid detection device further includes at least one control interface electrically connected to the processor and the light-emitting unit, and used to control or activate the processor and the light-emitting unit.
根據本發明的實施例,顯示單元及控制介面則設置在殼體的表面。 According to an embodiment of the present invention, the display unit and the control interface are arranged on the surface of the casing.
根據本發明的實施例,該顯示單元及該控制介面設置於該握持部的表面。 According to an embodiment of the present invention, the display unit and the control interface are disposed on the surface of the grip portion.
根據本發明的實施例,尿酸檢測裝置更包括反射單元,反射單元用以反射檢測光源,而光感測器則接收經過反射單元反射的檢測光源。殼體包括彼此連接的一檢測部與一握持部,檢測部形成有一液體通道,以讓待測溶液進入,檢測部相應於液體通道的一第一內表面設有發光單元與光感測器,檢測部相應於液體通道的一第二內表面設有反射單元,第一內表面相對於第二內表面,握持部容置處理器,且顯示單元及控制介面設置於握持部的表面。 According to an embodiment of the present invention, the uric acid detection device further includes a reflection unit, the reflection unit is used for reflecting the detection light source, and the light sensor receives the detection light source reflected by the reflection unit. The housing includes a detection part and a holding part which are connected to each other. The detection part forms a liquid channel to allow the solution to be tested to enter. The detection part is provided with a light-emitting unit and a light sensor corresponding to a first inner surface of the liquid channel. , the detection part is provided with a reflection unit corresponding to a second inner surface of the liquid channel, the first inner surface is opposite to the second inner surface, the holding part accommodates the processor, and the display unit and the control interface are arranged on the surface of the holding part .
根據本發明的實施例,尿酸檢測裝置更包括直流/直流轉換電路。直流/直流轉換電路用於將一電池的一輸入電壓轉換為發光單元、該光感測器、控制介面、處理器與顯示單元所使用的電壓。 According to an embodiment of the present invention, the uric acid detection device further includes a DC/DC conversion circuit. The DC/DC conversion circuit is used to convert an input voltage of a battery into a voltage used by the light emitting unit, the light sensor, the control interface, the processor and the display unit.
綜合以上所述,本發明實施例的尿酸檢測裝置不需要添加任何的化學試劑,且不需要採集尿液檢體,只要使用尿酸檢測裝置檢測用戶小解後之馬桶中的測待測溶液即能完成尿液中尿酸情況的檢測,從而達到居家健康監護的目的。 To sum up the above, the uric acid detection device of the embodiment of the present invention does not need to add any chemical reagents, and does not need to collect urine samples, as long as the uric acid detection device is used to detect the solution to be tested in the toilet after the user urinates. Complete the detection of uric acid in urine, so as to achieve the purpose of home health monitoring.
1:尿酸檢測裝置 1: Uric acid detection device
11:發光單元 11: Lighting unit
12:光感測器 12: Light sensor
13:處理器 13: Processor
14:顯示單元 14: Display unit
15:控制介面 15: Control interface
16:直流/直流轉換電路 16: DC/DC conversion circuit
17:電池 17: Battery
18:反射單元 18: Reflective unit
21:檢測部 21: Detection Department
211:液體通道 211: Liquid channel
22:握持部 22: Grip
D:尺徑 D: ruler diameter
m1、m2:斜率 m1, m2: slope
圖1為本發明實施例的尿酸檢測裝置的功能方塊圖。 FIG. 1 is a functional block diagram of a uric acid detection device according to an embodiment of the present invention.
圖2為本發明實施例的尿酸檢測裝置的立體圖。 FIG. 2 is a perspective view of a uric acid detection device according to an embodiment of the present invention.
圖3A為本發明實施例的尿酸檢測裝置的檢測部的剖面示意圖。 3A is a schematic cross-sectional view of a detection part of a uric acid detection device according to an embodiment of the present invention.
圖3B為本發明另一實施例的尿酸檢測裝置的檢測部的剖面示意圖。 3B is a schematic cross-sectional view of a detection portion of a uric acid detection device according to another embodiment of the present invention.
圖4是本發明實施例的尿酸檢測裝置的檢測光源中的290nm及260nm的吸收率的曲線圖。 4 is a graph showing the absorbance at 290 nm and 260 nm in the detection light source of the uric acid detection device according to the embodiment of the present invention.
請參閱圖1~圖3A,圖1為本發明實施例的尿酸檢測裝置的功能方塊圖,圖2為本發明實施例的尿酸檢測裝置的立體圖,以及圖3A為本發明實施例的尿酸檢測裝置的檢測部的剖面示意圖。尿酸檢測裝置1包括發光單元11、光感測器12、處理器13、顯示單元14、控制介面15、直流/直流轉換
電路16、電池17以及殼體(包括彼此連接的檢測部21與握持部22)。發光單元11與光感測器12設置於殼體的檢測部21,處理器13、顯示單元14、控制介面15、直流/直流轉換電路16與電池17設置於殼體的握持部22。發光單元11與光感測器12透過電線電性連接處理器13與直流/直流轉換電路16。處理器13電性連接顯示單元14與至少一控制介面15,以及直流/直流轉換電路16電性連接電池17、處理器13、顯示單元14與控制介面15。
Please refer to FIGS. 1 to 3A. FIG. 1 is a functional block diagram of a uric acid detection device according to an embodiment of the present invention, FIG. 2 is a perspective view of the uric acid detection device according to an embodiment of the present invention, and FIG. 3A is a uric acid detection device according to an embodiment of the present invention. A schematic cross-sectional view of the detection section. The uric
具體地,如圖2與圖3A,檢測部21形成有液體通道211,以讓馬桶中的待測溶液進入,檢測部21具有相應於液體通道211的第一內表面與第二內表面,第一內表面相對於第二內表面,例如,下內表面與上內表面。第一內表面與第二內表面設有發光單元11與光感測器12,握持部22容置處理器13,且顯示單元14及控制介面15(圖3A有兩個控制介面151、152)設置於握持部22的表面。液體通道211的尺徑D較佳地是1-10mm。
Specifically, as shown in FIG. 2 and FIG. 3A, the
於使用時,在用戶於馬桶小解後,用戶可手持尿酸檢測裝置1的握持部22,將檢測部21放到馬桶接觸馬桶中的待測溶液,使待測溶液進入液體通道211後,透過按壓控制介面15,使得尿酸檢測裝置1開始對待測溶液進行檢測,以檢測用戶之尿液的尿酸是否過高,或者尿酸量的多寡。
In use, after the user takes a bath in the toilet, the user can hold the holding
發光單元11用以產生發射光源,其中發射光源的波長介於200至450nm,發射光源用以投射在待測溶液上,並產生檢測光源。光感測器12用以接收檢測光源,並將檢測光源轉換為檢測訊號。處理器13由光感測器12接收檢測訊號,並由檢測訊號中290nm與260nm的部分,來判斷待測溶液中的尿酸是否過高。另外,處理器13更由檢測訊號推算出檢測光源中的290nm及260nm的吸收率,並由290nm及260nm的吸收率推算出待測溶液中
的尿酸含量,處理器13可以x86系列或ARM架構的處理器,或者也可以是其他類型的處理器。顯示單元14用以顯示待測溶液是否含有尿酸,顯示單元14可以是LCD、LED、電子紙、蜂鳴器、燈號、觸控屏幕或其他類型的顯示單元,且本發明不以此為限制。控制介面151、152可以分別是電源開關與量測啟動開關,以控制或啟動處理器13及發光單元11,控制介面151、152可以是機械開關、電容開關或者是觸控屏幕。直流/直流轉換電路16以用於將電池17(例如,使用串聯的兩顆1.5V乾電池、單一顆鋰電池或水銀電池來實現)的輸入電壓轉換為發光單元11、光感測器12、控制介面15、處理器13與顯示單元14所使用的電壓,例如將3V轉換為3.3V或5V。
The light-emitting
在此請注意,發光單元11可以是由一個以上之發光二極體、基板與透鏡構成,其中發光二極體為基板上,透鏡窗對應設置於發光二極體,並接收發光二極體發出光源,以形成發射光源。另外,光感測器12可以是由一個以上之光接收二極體(也可以改由CMOS感測器、CCD感測器或頻譜量測器實現)、基板與透鏡構成,其中光接收二極體為基板上,透鏡窗對應設置於光接收二極體,並接收檢測光源,以將檢測光源送給光接收二極體。
Please note that the light-emitting
請接著參照圖3B,圖3B為本發明另一實施例的尿酸檢測裝置的檢測部的剖面示意圖。相較於前一個實施例,尿酸檢測裝置1更包括反射單元18,反射單元18用以反射檢測光源,而光感測器12則接收經過反射單元18反射的檢測光源。檢測部21相應於液體通道211的第一內表面設有發光單元11與光感測器12,檢測部21相應於液體通道211的第二內表面設有反射單元18。另外,於此實施例中,發光單元11的發光二極體及光感測器12的光接收二極體位於同一塊基板,且共用同一個透鏡窗。
Please refer to FIG. 3B , which is a schematic cross-sectional view of a detection portion of a uric acid detection device according to another embodiment of the present invention. Compared with the previous embodiment, the uric
請對應參照圖4是本發明實施例的尿酸檢測裝置的檢測光源中的290nm及260nm的吸收率的曲線圖。由圖4可以知悉,當待測溶液中有尿酸,在260nm處的吸收率會有個波谷,在290nm處的吸收率會有個波峰,因此,處理器13判斷待測溶液中的尿酸是否過高的方式可以是以下至少其中一者:(1)由檢測訊號判斷檢測光源的290nm的吸收率是否大於260nm的吸收率;(2)由檢測訊號判斷檢測光源的290nm的吸收率與260nm的吸收率之比值是否大於一特定比值;(3)由檢測訊號判斷檢測光源的290nm的吸收率減去260nm的吸收率的差異值是否大於一特定差異值;(4)由檢測訊號判斷檢測光源的290nm的吸收率與260nm的吸收率的斜率來判斷;或(5)由該檢測訊號判斷該檢測光源的290nm的吸收率與260nm的吸收率的絕對值,透過對由不同的絕對值大小分布範圍建立一個查找表(Look-up table)進行查找,以判斷尿酸是否過高。
Please refer to FIG. 4 , which is a graph of the absorbance at 290 nm and 260 nm in the detection light source of the uric acid detection device according to the embodiment of the present invention. It can be known from FIG. 4 that when there is uric acid in the solution to be tested, the absorption rate at 260 nm will have a trough, and the absorption rate at 290 nm will have a peak. Therefore, the
由圖4可以知悉,當尿酸存在時,檢測光源的290nm的吸收率大於檢測光源的260nm的吸收率,因此,檢測光源的290nm的吸收率減去檢測光源的260nm的吸收率會大於0,且檢測光源的290nm的吸收率與檢測光源的260nm的吸收率的比值大於1。另外,檢測光源的290+delta nm的斜率m2會是負的,而檢測光源的260+delta nm的斜率m1會是正的,其中delta是趨近於0的正值。 It can be known from Figure 4 that when uric acid exists, the absorption rate of the detection light source at 290 nm is greater than that of the detection light source at 260 nm. Therefore, the absorption rate of the detection light source at 290 nm minus the absorption rate of the detection light source at 260 nm will be greater than 0, and The ratio of the absorption rate of the detection light source at 290 nm to the absorption rate of the detection light source at 260 nm is greater than 1. In addition, the slope m2 of the detection light source at 290+delta nm will be negative, and the slope m1 of the detection light source at 260+delta nm will be positive, where delta is a positive value approaching 0.
總結來說,先前技術要檢測尿酸時,有以下技術問題:在採檢前需要用戶空腹8-10小時;用戶必須到專業醫療單位進行採檢;檢驗需要使用化學試劑搭配光電分析進行檢測;以及檢測欠缺即時性,難以即時監測尿酸情況,以降低痛風的發生機率。相較於先前技術,本發明的尿酸檢測裝 置則解決了上述技術問題,本發明的尿酸檢測裝置在使用時:不需要採尿與不需要特定到特定專業醫療單位,因本發明直接將檢測部部分沉入馬桶中的待測溶液即可檢測;不需要添加生化試劑、不需攪拌且不需試紙,因本發明直接將檢測部部分沉入馬桶中的待測溶液時,待測溶液會自然地因為進入液體通道,且檢測方式不是讓尿酸與試劑發生反應,而是根據檢測光源290nm與260nm之吸收率的情況直接判斷;以及可以即時地檢測尿酸高低,以提醒用戶避免痛風發生,因本發明為可攜式,且直接將檢測部部分沉入馬桶中的待測溶液即可檢測。 To sum up, when the prior art detects uric acid, there are the following technical problems: the user needs to fast for 8-10 hours before the test; the user must go to a professional medical unit for the test; the test needs to use chemical reagents with photoelectric analysis for detection; and The lack of immediate detection makes it difficult to monitor uric acid in real time to reduce the incidence of gout. Compared with the prior art, the uric acid detection device of the present invention The uric acid detection device of the present invention solves the above-mentioned technical problems. When the uric acid detection device of the present invention is used, it does not need to collect urine and does not need to be assigned to a specific professional medical unit, because the present invention directly submerges the detection part into the solution to be tested in the toilet to detect There is no need to add biochemical reagents, no stirring and no test paper, because when the present invention directly sinks the detection part into the solution to be tested in the toilet, the solution to be tested will naturally enter the liquid channel, and the detection method is not to let uric acid It reacts with the reagent, but directly judges according to the absorption rate of the detection light source at 290nm and 260nm; and can detect the level of uric acid in real time to remind the user to avoid gout, because the present invention is portable, and the detection part is directly connected. The solution to be tested can be detected by sinking into the toilet.
以上所述者,僅為本發明之一較佳實施例而已,並非用來限定本發明實施之範圍,即凡依本發明申請專利範圍所述之形狀、構造、特徵及精神所為之均等變化與修飾,均應包括於本發明之申請專利範圍內。 The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. Modifications should be included within the scope of the patent application of the present invention.
1:尿酸檢測裝置 1: Uric acid detection device
11:發光單元 11: Lighting unit
12:光感測器 12: Light sensor
13:處理器 13: Processor
14:顯示單元 14: Display unit
15:控制介面 15: Control interface
16:直流/直流轉換電路 16: DC/DC conversion circuit
17:電池 17: Battery
21:檢測部 21: Detection Department
22:握持部 22: Grip
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CN102239401A (en) * | 2008-12-03 | 2011-11-09 | 格伦德福斯管理联合股份公司 | Sensor system for capturing and specifying individual particles in a fluid |
CN204882361U (en) * | 2014-05-08 | 2015-12-16 | B·布莱恩·阿维图姆股份公司 | A equipment that be arranged in quantitative determination in fluid secreting / draw from health or external blood purify fluid select and to select material |
CN111665368A (en) * | 2019-03-05 | 2020-09-15 | 株式会社日立高新技术 | Automatic analyzer |
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CN102239401A (en) * | 2008-12-03 | 2011-11-09 | 格伦德福斯管理联合股份公司 | Sensor system for capturing and specifying individual particles in a fluid |
CN204882361U (en) * | 2014-05-08 | 2015-12-16 | B·布莱恩·阿维图姆股份公司 | A equipment that be arranged in quantitative determination in fluid secreting / draw from health or external blood purify fluid select and to select material |
CN111665368A (en) * | 2019-03-05 | 2020-09-15 | 株式会社日立高新技术 | Automatic analyzer |
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