TWI746286B - Hydrogel composition and hydrogel contact lens - Google Patents

Abstract

A hydrogel composition includes: a hydrophilic monomer, a cross-linking agent, an initiator, and a rotaxane molecule. The hydrophilic monomer is 60 parts by weight to 99.85 parts by weight, the cross-linking agent is 0.01 part by weight to 1 part by weight, the initiator is 0.01 part by weight to 2 parts by weight, and the rotaxane molecule is 0.1 parts by weight to 15 parts by weight. The rotaxane molecule includes at least one cyclic molecule and at least one linear molecule penetrating through the cyclic molecule in a string shape. The weight ratio of the rotaxane molecule to the hydrophilic monomer is between 1: 6 and 1:99. The present disclosure further provides a hydrogel contact lens, which is formed by the hydrogel composition. The present invention also discloses a hydrogel contact lens.

Description

Water gel composition and water gel lens

The present invention relates to a water gel composition, in particular to a water gel composition and a water gel lens, which can load and slow-release active ingredients.

The delivery of ophthalmic drugs (or active ingredients) has been an important challenge for ophthalmologists for the past few decades. In the past, topical eye drops were commonly used to treat the eyes of the human body. However, in this way of supplying medicine, the medicine will be diluted instantly after being dripped into the eyes of the human body, and the medicine will be easily discharged from the tear orifice. The retention time of the drug in the eyes of the human body is short, which leads to the problem of poor therapeutic effect. Therefore, it is necessary to consider increasing the frequency of drug use or increasing the dose of the drug, but it increases the risk of side effects of the drug. Therefore, the above-mentioned administration method is not a good administration method.

Therefore, the inventor feels that the above-mentioned deficiency can be improved, and with great concentration of research and the application of scientific theory, finally proposes an invention with a reasonable design and effective improvement of the above-mentioned deficiency.

The technical problem to be solved by the present invention is to provide a water gel composition and a water gel lens in view of the deficiencies of the prior art.

In order to solve the above-mentioned technical problems, one of the technical solutions adopted by the present invention is to provide a hydrogel composition, which comprises: a hydrophilic monomer of 60 parts by weight to 99.85 parts by weight; a crosslinking agent of 0.01 parts by weight Parts to 1 part by weight; an initiator, 0.01 parts by weight to 2 parts by weight; and a rotaxane molecule, 0.1 parts by weight to 15 parts by weight; wherein the rotaxane molecule contains at least one cyclic molecule And at least linear molecules passing through at least one of the cyclic molecules in a string; wherein the weight ratio of the rotaxane molecule to the hydrophilic monomer is between 1:6 to 1:99.

In order to solve the above technical problem, another technical solution adopted by the present invention is to provide a water gel lens, including: a lens body formed by the above water gel composition.

One of the beneficial effects of the present invention is that the water gel composition and the water gel lens for preparing the water gel lens provided by the present invention can adopt the technical solution of introducing rotaxane molecules into the water gel composition, So that the final formed hydrocolloid lens can have the effect of loading and slow-release of active ingredients.

It is worth mentioning that when the rotaxane molecule is introduced, the hydrocolloid lens of the present invention not only has the effect of loading and slow-release of the active ingredient, but also can maintain the required characteristics of the contact lens, such as the lens base curve ( base curve, BC), lens center thickness (CT), lens diameter (diameter, DIA), refractive index, visible light transmittance or dynamic contact angle... etc.

In order to further understand the features and technical content of the present invention, please refer to the following detailed description and drawings about the present invention. However, the provided drawings are only for reference and description, and are not used to limit the present invention.

The following are specific examples to illustrate the implementation of the "water gel composition and water gel lens" disclosed in the present invention. Those skilled in the art can understand the advantages and effects of the present invention from the content disclosed in this specification. The present invention can be implemented or applied through other different specific embodiments, and various details in this specification can also be based on different viewpoints and applications, and various modifications and changes can be made without departing from the concept of the present invention. The following embodiments will further describe the related technical content of the present invention in detail, but the disclosed content is not intended to limit the protection scope of the present invention. In addition, the term "or" used in this document may include any one or a combination of more of the associated listed items depending on the actual situation.

In this article, unless the article is specifically limited in the context, "a" and "the" can generally refer to a single one or more. It will be further understood that the "including", "including", "having" and similar words used in this text indicate the recorded features, regions, integers, steps, operations, elements and/or components, but do not exclude The described or additional one or more other features, regions, integers, steps, operations, elements, components, and/or groups thereof.

According to the technical shortcomings mentioned in the prior art, the delivery of ophthalmic drugs (or active ingredients) has been a very important challenge for ophthalmologists in the past decades. In the past, topical eye drops were commonly used to treat the eyes of the human body. However, in this way of supplying medicine, the medicine will be diluted instantly after being dripped into the eyes of the human body, and the medicine will be easily discharged from the tear orifice. The retention time of the drug in the eyes of the human body is short, which leads to the problem of poor therapeutic effect. Therefore, it is necessary to consider increasing the frequency of drug use or increasing the dose of the drug, but it increases the risk of side effects of the drug. Therefore, the above-mentioned administration method is not a good administration method.

In order to improve the above technical drawbacks, one of the objectives of the present invention is to provide a new type of hydrogel lens, which is a strategy for the transportation of active ingredients. The present invention has become a new delivery mode of active ingredients by using a new type of hydrogel lens with slow-release technology of active ingredients. The technology of the present invention can keep the active ingredients on the contact lens, prolong the residence time of the active ingredients on the eyes, improve the utilization rate of the active ingredients, thereby prolong the comfort of the wearer, and even achieve long-term maintenance effects.

[Water glue composition]

In order to achieve the above objective, embodiments of the present invention provide a water gel composition for preparing water gel lenses. The hydrogel composition includes: a hydrophilic monomer, a crosslinker, an initiator, and a rotaxane.

In terms of amount, the amount of the hydrophilic monomer is preferably 60 parts by weight to 99.85 parts by weight, and particularly preferably 68.88 parts by weight to 99.85 parts by weight. The amount of the crosslinking agent is preferably 0.01 part by weight to 1 part by weight, and particularly preferably 0.04 part by weight to 0.57 part by weight. The amount of the initiator is preferably 0.01 parts by weight to 2 parts by weight, and particularly preferably 0.05 parts by weight to 0.72 parts by weight. In addition, the amount of the rotaxane molecule is usually 0.1 parts by weight to 15 parts by weight, preferably 0.1 parts by weight to 12 parts by weight, and particularly preferably 0.5 parts by weight to 8 parts by weight.

In order to allow the rotaxane molecules to be uniformly dispersed in the hydrogel composition and to exert the expected effect, the weight ratio of the rotaxane molecules to the hydrophilic monomer has a specific ratio range. For example, the weight ratio of the rotaxane molecule to the hydrophilic monomer is usually between 1:6 and 1:99, preferably between 1:11 and 1:99, and particularly preferably It is between 1:14 and 1:74, but the present invention is not limited to this.

If the weight ratio of the rotaxane molecule to the hydrophilic monomer is lower than the lower limit of the above ratio range (such as 1:1), the rotaxane molecule may not be uniformly dispersed in the hydrogel composition due to the high addition ratio , So that the final formed water gel lens has poor quality (such as: poor refractive index or poor light transmittance).

Conversely, if the weight ratio of the rotaxane molecule to the hydrophilic monomer is higher than the upper limit of the above range (such as 1:200), the rotaxane molecule may not be included in the final formed hydrogel lens due to the low addition ratio. Play the expected effect (such as effective loading and slow release of active ingredients).

The following describes the material types of each component in the water gel composition of the embodiment of the present invention.

The molecular structure of the hydrophilic monomer preferably has a vinyl group, an acetyl group, a propenyl group, or an acryl group.

In various embodiments of the present invention, the hydrophilic monomer is selected from N-vinyl pyrrolidone (NVP), 2-hydroxyethyl methacrylate (HEMA) , Methacrylic acid (MAA), methyl methacrylate (MMA), acrylic acid (AAc), N,N-dimethyl acrylamide (DMA) ), 2-methyl-2-acrylic acid-2,3-dihydroxypropyl ester (2,3-dihydroxypropyl methacrylate, GMMA), N,N-dimethyl methacrylamide (N,N-dimethyl methacrylamide) , And at least one of the material group consisting of N-vinyl-N-methyl acetamide (N-vinyl-N-methyl acetamide).

In various embodiments of the present invention, the water gel composition further includes a silicone compound, and the silicone compound is selected from the group consisting of a silicon monomer, a silicon polymer, and a silicon prepolymer At least one of the group. In this way, the finally formed water gel lens can be a silicon water gel lens.

In various embodiments of the present invention, the crosslinking agent is selected from the group consisting of ethylene glycol dimethacrylate and diethylene glycol dimethacrylate. dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, allyl methacrylate , Triethylene glycol dially ether, tetraethylene glycol dially ether, and trimethylolpropane trimethacrylate (1,1,1-trimethylolpropane trimethacrylate) at least one of the material group.

In various embodiments of the present invention, the initiator is a photoinitiator.

The photoinitiator is selected from bis(1-(2,4-difluorophenyl)-3-pyrrolyl) titanocene (bis(2,6-difluoro-3-(1-hydropyrro-1- yl)- phenyl)titanocene), phenylbis-(2,4,6-trimethylbenzoyl)-phosphine oxide and 2-hydroxy-2- At least one of the material group consisting of 2-hydroxy-2-methyl-1-phenyl-1-porpanone.

More specifically, the rotaxane molecule includes at least one cyclic molecule and at least a linear molecule, and at least one linear molecule penetrates through at least one cyclic molecule in a string.状 Molecule.

In order to allow the rotaxane molecule to effectively load and release the active ingredient, the weight ratio of the cyclic molecule to the linear molecule has a specific ratio range. For example, the weight ratio of at least one said cyclic molecule to at least one said linear molecule is preferably between 1:1 and 50:1, and particularly preferably between 5:1 and 35:1. between.

That is, in the rotaxane molecule, the number of the cyclic molecules is usually multiple, the number of the linear molecule is usually one, and one linear molecule penetrates to a plurality of the In the cyclic molecule.

Thereby, a sufficient space can be formed between the cyclic molecule and the linear molecule to load an effective dose of the active ingredient. Furthermore, there is a dynamic structure between the cyclic molecule and the linear molecule, so that the rotaxane molecule can achieve the effect of slowly releasing the active ingredient.

If the weight ratio of the cyclic molecule to the linear molecule exceeds the above-mentioned specific ratio range, the effect of the rotaxane molecule on loading and slow-release of the active ingredient may become unsatisfactory.

In terms of material types, the cyclic molecule may be, for example, cyclodextrin (cyclodextrin) or a derivative thereof, but the present invention is not limited thereto.

In various embodiments of the present invention, the cyclodextrin is selected from α-cyclodextrin (α-cyclodextrin), β-cyclodextrin (β-cyclodextrin), γ-cyclodextrin (γ-cyclodextrin) , Hydroxypropyl-β-cyclodextrin (hydroxypropyl-β-cyclodextrin), (2-hydroxypropyl)-γ-cyclodextrin ((2-hydroxypropyl)-γ-cyclodextrin), sulfobutyl ether-β- At least one of the material group consisting of cyclodextrin (sulfobutylether-β-cyclodextrin) and methyl-β-cyclodextrin (methyl-β-cyclodextrin).

Furthermore, the cyclic molecule may also be, for example, a crown ether (crown ether) or a derivative thereof, but the present invention is not limited thereto.

In various embodiments of the present invention, the crown ether is selected from 12-crown-4 (12-crown-4), 15-crown-5 (15-crown-5), 18-crown-6 (18 -crown-6), benzo-18-crown-6 (benzo-18-crown-6), benzo-15-crown-5 (benzo-15-crown-5), dicyclohexyl-18-crown-6 (Dicyclohexyl-18-crown-6), 2-(hydroxymethyl)-12-crown-4-ether, 2-(hydroxymethyl)-15 -Crown-5-ether (2-(hydroxymethyl)-15-crown-5-ether) and 2-(hydroxymethyl)-18-crown-6-ether (2-(hydroxymethyl)-18-crown-6- At least one of the material groups formed by ether).

Furthermore, the linear molecule is at least selected from the group consisting of polyethylene glycol (PEG), polyvinyl alcohol (PVA) and polypropylene glycol (PPG). one of them.

（1） Among them, polyethylene glycol has a structure such as formula (1):

(1)

（2） Among them, polyvinyl alcohol has a structure such as formula (2):

(2)

（3） Among them, polypropylene glycol has a structure such as formula (3):

(3)

Among them, n is preferably a positive integer greater than 4, and particularly preferably a positive integer between 100 and 6,000. Furthermore, the average molecular weight of the linear molecule is preferably between 200 and 20,000, but the present invention is not limited thereto.

It is worth mentioning that one of the objectives of the present invention is to introduce "rotaxane molecules" into the water gel composition used to prepare the water gel lens, so that the rotaxane molecule can load the active ingredients to make the water gel lens It can be equipped with inclusion technology, and has the effect of loading and slow-release of active ingredients.

Among them, the above-mentioned "inclusion technology" is to embed the active ingredient (or the target substance) in the cyclic molecule, so that the active ingredient can assume a stable state. Furthermore, cyclic molecules can be combined with linear molecules to form rotaxane molecules to achieve the purpose of slow release of active ingredients.

From another perspective, "inclusion technology" refers to a technology in which a molecule is embedded in the cavity structure of another molecule to form an inclusion compound. Among them, the inclusion compound is composed of the addition of a host molecule and a guest molecule. In addition, the host molecule has a relatively large cavity structure, which is enough to contain the guest molecules to form a molecular capsule.

In a specific embodiment of the present invention, the cyclic molecule in the rotaxane molecule is cyclodextrin, and the linear molecule is polyethylene glycol (PEG), but the present invention is not limited thereto.

Among them, the molecular shape of cyclodextrin is like a tire. The secondary hydroxyl group on the C-2 and C-3 atoms of each glucose residue is located at one end of the molecule of the cyclodextrin ring, and its diameter is slightly larger, while C-6 The upper first hydroxyl group is located at the other end of the cyclodextrin ring and has a slightly smaller diameter. Therefore, the inside of the cyclodextrin molecule is a hydrophobic cavity structure, which can provide fat-soluble active ingredients (such as menthol, vitamin E acetate) to enter and be loaded into it.

β-環糊精（β-cyclodextrin）

γ-環糊精（γ-cyclodextrin）

The following are the chemical structures of the three main types of cyclodextrins. Cyclodextrin type Chemical structure α-cyclodextrin (α-cyclodextrin)

β-cyclodextrin (β-cyclodextrin)

γ-cyclodextrin (γ-cyclodextrin)

When the cyclodextrin and the fat-soluble active ingredient are dissolved in a solvent together, the fat-soluble active ingredient usually enters the hydrophobic cavity structure of the cyclodextrin, and the cyclodextrin utilizes its peripheral hydroxyl group (-OH group) It can be used with aqueous solutions or highly polar solutions (such as hydrophilic monomers or contact lens maintenance solutions) to increase the solubility of fat-soluble active ingredients.

In addition to forming a complex of cyclodextrin and fat-soluble active ingredients to increase its solubility, the complex can be combined with linear molecules (such as PEG) to form rotaxane molecules to facilitate stable release of the loaded Active ingredient.

More specifically, the above-mentioned rotaxane molecule is formed by the supramolecular force between a cyclic molecule and a linear molecule. The rotaxane molecule contains one or several cyclic molecules (wheels) and one linear molecule (shaft). Linear molecules and cyclic molecules are connected by weak interaction "mechanical bonds" instead of strong covalent bonds or coordination bonds. Therefore, this supramolecular polymer has less stability and a dynamic structure, which is suitable for loading active ingredients such as small molecule drugs, protein drugs, or genes.

It is worth mentioning that the inventor of the present application has also done a lot of research in academic literature regarding the ability of rotaxane molecules to load active ingredients.

For example, the document Pol. J. Chem. Tech. 2016 18(3) 110-116 pointed out that cyclodextrin can effectively load menthol. Document J Fluoresc. 2007 17 265-270 pointed out that hydroxypropyl-β-cyclodextrin (HP-β-CD) can effectively load vitamin B12 (Vitamin B12). In addition, the document J Agric Food Chem. 2017 65(26) 5404-5412 also pointed out that hydroxypropyl-β-cyclodextrin (HP-β-CD) can effectively load vitamin E (Vitamin E), which in turn increases the solubility of vitamin E in water.

It is also worth mentioning that, as mentioned above, the weight ratio of the rotaxane molecule to the hydrophilic monomer is usually between 1:6 and 1:99. In some specific embodiments of the present invention, the molecular structure of the hydrophilic monomer preferably has an acryl group functional group, and in these specific embodiments, the rotaxane molecule and the hydrophilic The weight ratio of the sexual monomer is preferably between 1:6 to 1:94.

Wherein, the functional group having an acryl group may be, for example, at least one of the following four chemical structures.

Furthermore, the inventors of the present application have discovered that the preferred range of the weight ratio of the rotaxane molecule to the hydrophilic monomer is also different under different selections of cyclodextrin materials.

For example, when the cyclic molecule in the rotaxane molecule is α-cyclodextrin (α-cyclodextrin) or β-cyclodextrin (β-cyclodextrin), the interaction between the rotaxane molecule and the hydrophilic monomer The weight ratio is preferably between 1:11 and 1:54. When the cyclic molecule in the rotaxane molecule is hydroxypropyl-β-cyclodextrin, the weight ratio of the rotaxane molecule to the hydrophilic monomer is preferably between 1:17 To 1:86. Furthermore, when the cyclic molecule in the rotaxane molecule is (2-hydroxypropyl)-γ-cyclodextrin ((2-hydroxypropyl)-γ-cyclodextrin), the rotaxane molecule and the hydrophilic monomer The weight ratio of the body is preferably between 1:19 to 1:94.

In order to increase the ultraviolet light blocking ability of the hydrogel lens, in various embodiments of the present invention, the hydrogel composition further includes an ultraviolet light blocking monomer, and the ultraviolet light blocking monomer is 0.34 parts by weight to 1.68 parts by weight. Parts by weight.

Wherein, the UV blocking monomer is at least one selected from the group consisting of a monomer with benzophenone and a material group with benzotriazole.

In order to increase the solubility of the hydrogel composition, in various embodiments of the present invention, the hydrogel composition further includes a co-solvent, and the co-solvent is 4.33 parts by weight to 12.67 parts by weight.

Wherein, the co-solvent is selected from glycerol, isopropyl alcohol, n-butanol, t-butanol, t-amyl alcohol And at least one of the material group consisting of n-hexanol.

In order to make the hydrogel lens have a specific color, in various embodiments of the present invention, the hydrogel composition further includes a dye, and the dye is 0.002 parts by weight to 0.039 parts by weight.

Wherein, the dye is selected from reactive blue 19 (disodium,1-amino-9,10-dioxo-4-[3-(2-sulfonatooxyethylsulfonyl)anilino]anthracene-2-sulfonate), Sudan No. 3 (1-[ 4-(Phenylazo)phenylazo]-2-naphthol, Sudan III), indigo (2,2'-Bis(2,3-dihydro- 3-oxoindolylidene), Indigo) and quinoline yellow (disodium 2-(1,3) -dioxo- 2,3-dihydro-1H-inden-2-yl)quinolone-6,8-disulfonate, Quinoline yellow) at least one of the material group.

Furthermore, in a preferred embodiment of the present invention, the linear molecules of the rotaxane molecule (eg, PEG, PVA, PPG) have a relatively high molecular weight, and thus have a relatively long polymer chain segment. Specifically, the linear molecules in the rotaxane molecule have an average molecular weight between 2,000 and 20,000, preferably between 4,000 and 15,000, and particularly preferably between 4,000 and 8,000. According to the above configuration, since the linear molecule in the rotaxane molecule has a sufficiently long polymer segment, the cyclic molecule has enough space on the linear molecule to slide, so that the cyclic molecule Molecules are not easily detached from linear molecules. Accordingly, the rotaxane molecule may not need to contain a slopper/capping group for preventing the cyclic molecule from detaching from both ends of the linear molecule. In other words, in the rotaxane molecule, the two ends of the linear molecule do not need to be formed with a blocking group, which can still stably maintain the shape of the rotaxane molecule.

Furthermore, in the rotaxane molecule, the outer periphery of the cyclic molecule (such as cyclodextrin) has a hydrophilic functional group (such as a hydroxyl group, -OH group), so that the The periphery has high hydrophilicity. Furthermore, the inner side of the cyclic molecule has a hydrophobic cavity structure, so that the inner side of the cyclic molecule has higher hydrophobicity, and the hydrophobic cavity structure can be used to provide fat-soluble active ingredients to enter In it, to enhance the carrying effect of active ingredients. Since the periphery of the cyclic molecule has a hydrophilic functional group, the rotaxane molecule can pass through the hydrophilic functional group on the periphery of the cyclic molecule and the hydrophilic monomer (such as: NVP, HEMA, etc.) in the hydrogel composition. ) To act or combine to enable the rotaxane molecules to be uniformly dispersed in the hydrogel composition (based on the interaction between polar molecules and polar molecules).

More specifically, as shown in FIG. 1, in the hydrogel composition 100, the linear molecules 11 of the rotaxane molecule 1 are dispersed in the hydrophilic monomer 2 in a twisted form, and The rotaxane molecule 1 includes a plurality of cyclic molecules 12 threaded on a linear molecule 11 in a series connection.

It is worth mentioning that in the hydrogel composition 100, a plurality of cyclic molecules 12 connected in series and a plurality of adjacent cyclic molecules 12 in series can attract each other through the force of hydrogen bonds, and Arranged on top of each other (as shown in Figure 2).

In addition, please continue to refer to FIG. 1, in the hydrogel composition 100, part of the cyclic molecules 12 are not pierced on the linear molecules 11, but scattered on the outside of the linear molecules 11. It exists as an independent molecule, but the present invention is not limited to this.

Furthermore, as shown in Figure 2, based on the force of the hydrogen bond, a plurality of cyclic molecules 12 connected in series on the linear molecule 11 are heads to heads and tails to tails. ).

In addition, it is worth mentioning that the hydrogel composition 100 can have relatively excellent tensile properties through the addition of the rotaxane molecule 1. Specifically, the hydrogel lens made from the hydrogel composition 100 has an elongation between 250% and 380%, and more preferably between 320% and 380%.

[Preparation method of water glue composition]

The method for preparing rotaxane molecules can be, for example, by adding cyclic molecules to linear molecules in the amount ratio described in the examples of this article, and mixing and stirring for several hours until the complete reaction is completed to obtain a reaction Solution; The reaction solution is then dried to obtain rotaxane molecular powder.

The preparation method of the hydrogel composition can be, for example, by slowly adding the above-mentioned rotaxane molecule, crosslinking agent, and starting agent to the hydrophilic monomer, and mixing and stirring for several hours until the complete reaction is completed to obtain Water glue composition. That is, in this embodiment, the cyclic molecules and linear molecules are formed into rotaxane molecules before the hydrogel composition is prepared.

In addition, the preparation method of the hydrogel composition can also be, for example, adding cyclic molecules, linear molecules, crosslinking agents, initiators and other materials slowly to the hydrophilic monomer, and mixing and stirring for several hours until complete After the reaction, the hydrogel composition is obtained. In other words, in this embodiment, the cyclic molecules and linear molecules are formed into rotaxane molecules while preparing the hydrogel composition.

[Preparation method of water gel lens]

The preparation method of the hydrogel lens may be, for example, injecting the above-mentioned hydrogel composition into a mold for manufacturing the hydrogel lens, and performing a curing molding process on the hydrogel composition to form a semi-finished product of the dry film of the hydrogel lens.

Then, soak the dry semi-finished product of the hydrogel lens in a buffer solution until the hydrogel lens swells (hydration process). Then, the buffer solution is filled in the packaging container, the hydrogel lens is immersed in the buffer solution, and then sealed and sterilized, thus completing the production of the contact lens product.

Among them, the above-mentioned active ingredients (such as small molecule drugs, protein drugs, or genes) can be added or incorporated into one of the materials used to make contact lenses; or, for example, can also be used in the mold release and swelling process of contact lenses. Load on the contact lens; or, it can also be dissolved in the buffer solution for immersing the contact lens and loaded on the contact lens. Accordingly, when the user attaches the contact lens to the surface of the eyeball, the above-mentioned active ingredients can be slowly released from the lens over time and be absorbed by the user's eye.

In other words, how are the above active ingredients (such as small molecule drugs, protein drugs or genes) added or loaded into the rotaxane molecule? In various embodiments of the present invention, the above-mentioned active ingredient may be added during the preparation of the lens material, added during the hydration of the lens, or added in the preservation solution, for example.

Under this sustained-release system, the active ingredients that the contact lens can load can be, for example, ingredients with cooling or anti-itch effects, such as menthol (menthol, l-menthol), camphor (d-camphor, dl-camphor), and borneol. (D-borneol), potassium chloride (potassium chloride).

The active ingredient may also be, for example, an ingredient having an anti-inflammatory effect, such as: lysozyme hydrochloride, dipotassium glycyrrhizinate, 6-aminocaproic acid, ε-aminocaproic acid, 6-aminohexanoic acid, etc. acid), zinc sulfate, vitamin B2 (vitamin B2, riboflavin), sodium azulene sulfonic acid, sulfamethoxazole (sulfamethoxazole, sulfamethoxazole sodium), prano-profen (prano-profen) .

The active ingredient may also be, for example, an ingredient that has the effect of relieving the symptoms of conjunctival hyperemia, such as naphazoline (naphazoline, naphazoline hydrochloride), tetrahydrozoline (tetrahydrozoline, tetryzoline, tetrahydrozoline hydrochloride), and chlorobutanol (chlorobutanol). , Chlorobutanol hemihydrate, phenylephrine hydrochloride, phenylephrine. The active ingredient can also be, for example, an ingredient with anti-oxidation or eye fatigue effects, such as vitamin E (vitamin E, α-tocopheryl acetate), L-potassium aspartate, and aspartate. Magnesium (magnesium L-aspartate), chondroitin sulfate (chondroitin sulfate, chondroitin sulfate sodium salt, sodium chondroitin chloride), neostigmine methylsulfate (neostigmine methylsulfate), arginine (asparagine), vitamin B12 (vitamin B12) , Cyanocobalamin, methylcobalamin, adenosylcobalamin, hydroxocobalamin, vitamin B5 (vitamin B5, pantothenic acid), vitamin B6 (vitamin B6, pyridoxine hydrochloride), vitamin A (vitamin A, vitamin A palmitate), taurine (taurine).

The active ingredient may also be, for example, an ingredient having anti-allergic or anti-itch effects, such as diphenhydramine (diphenhydramine, diphenhydramine hydrochloride), chlorpheniramine (chlorpheniramine, chlorpheniramine maleate), and tranilast.

Furthermore, the active ingredient may also be, for example, an ingredient with moisturizing or soothing effects, such as boric acid, glycerine, hyaluronic acid, polyol, allantoin ( allantoin).

[Water Gel Lens]

The embodiment of the present invention also provides a water gel lens, the water gel lens is formed by the above water gel composition.

Wherein, the rotaxane molecules are distributed on at least a concave arc surface or a convex arc surface of the lens body to form a layer of rotaxane molecules, and the rotaxane molecules are configured to carry an active ingredient. Wherein, the active ingredient is at least one of small molecule drugs, protein drugs, and genes.

Thereby, when the user attaches the contact lens to the surface of the eyeball, the above-mentioned active ingredients can be slowly released from the lens over time and absorbed by the user's eye.

Furthermore, the refractive index of the lens body is preferably between 1.315 and 1.598, and particularly preferably between 1.398 and 1.485.

The visible light transmittance of the lens body is preferably not less than 90%, and particularly preferably not less than 95%.

The dynamic contact angle (DCA) of the lens body is preferably less than 38, and particularly preferably less than 35, so as to have good wettability.

In various embodiments of the present invention, the lens body of the contact lens may also be, for example, any lens body known in the technical field. For example, the lens body may be a rigid oxygen permeable contact lens (rigid gas permeable, RGP), a hydrogel soft contact lens (hydrogel soft contact lens, SCL), or a silicone hydrogel soft contact lens (silicone hydrogel). soft contact lens).

[Experimental data test]

Hereinafter, the content of the present invention will be described in detail with reference to exemplary examples 1 to 4 in Table 1. However, the following examples are only used to help understand the present invention, and the scope of the present invention is not limited to these examples.

The exemplary lenses in Table 1 are obtained by the above preparation method of the water gel composition and the preparation method of the water gel lens.

After the lenses of the exemplary examples in Table 1 are prepared, they are tested for physical and chemical properties, such as: base curve (BC), center thickness (CT), diameter (diameter, DIA), and refractive index (refractive index). ), light transmittance, water content, atmospheric dehydration, lubricity, dynamic contact angle (DCA), elongation, water Water extraction test and hexane extraction test.

The dynamic contact angle is measured by using a dynamic contact angle measuring instrument, and the captive bubble method is used as the method to measure the contact angle. The bubble sticking method is a measurement method often used to measure the wettability or hydrophilicity of contact lenses. Generally speaking, the dynamic contact angle of water gel contact lenses can be less than 50 degrees. According to the following examples 1 to 4, the hydrogel lenses produced have dynamic contact angles of no more than 80 degrees, specifically, no more than 38 degrees, and more specifically, no more than 35 degrees. Has good wettability.

The measurement of atmospheric dehydration rate is one of the important indicators that can be used to evaluate the degree of water retention of lens materials. The measurement method is as follows: put several hydrated and swelled hydrogel lenses on a damp cloth and gently wipe to remove excess water; put the above lenses in the sample pan on the balance, weigh the record lens Weight, and record the weight at different time points (such as: the 10th minute of air dehydration, the 30th minute of air dehydration, the 60th minute of air dehydration). Table 1 shows the measurement results of the atmospheric dehydration rate of the lens in different examples.

It is understood that the rapid drying of contact lenses is one of the main reasons for wearers to consider stopping using contact lenses. As shown in Table 1, the inventor of the present application unexpectedly discovered that the hydrogel lens with rotaxane molecules added (Exemplary Examples 1 to 4) is compared with the hydrocolloid lens without rotaxane molecules (Comparative Example 1). Molecular hydrogel lenses have a lower dehydration rate. In other words, the drying rate of contact lenses with added rotaxane molecules is relatively slow, and the wearer is less likely to feel the lens body dry.

The measurement of elongation is used to evaluate the tensile elasticity of the lens. More specifically, the measurement method is to use a ruler to measure the lens after hydration and swelling to carry out this experiment. The visible length of the body is 0.5 cm), and the left fixed end of the lens is aligned with the 0 cm of the ruler. With a fixed force, stretch the lens body along the direction of its central axis to the right side of the lens body to record the break of the lens body. The last length (cm) before the stretch, and then subtract the value of the length before stretching from the value of the stretched length, and then divide by the value of the length before stretching to calculate the elongation value, which is expressed as a percentage.

The calculation formula of elongation is: Elongation (%) = Length after stretching-Length before stretching x 100% Length before stretching

The measurement of elongation is one of the important indicators for evaluating the properties of lenses. When the lens is too hard (for example, the elongation is less than 150%), the lens will easily cause discomfort to the eyes when the user wears it. When the lens is too soft (for example, the elongation is greater than 500%), when the user prepares to wear the lens and places the lens on the finger pad, it will be difficult for the lens to be placed flat on the finger pad, making it difficult to wear the lens. The hydrogel lenses manufactured according to the following example 1 to 4 have an elongation between 250% and 380%, more specifically between 320% and 380%.

The measurement of lubricity is one of the important indicators for evaluating the wearing comfort of lenses. Contact lens lenses with good lubricity can provide users with good wearing comfort. The evaluation method is to use a blind test score, the score is 1 to 10 points, the higher the score, the better the lubricity performance. The hydrogel lenses produced according to the following example 1 to 4 all have a score of about 5 points.

The measurement of water content refers to the amount of water absorbed by the lens body under equilibrium. The water content is determined according to ISO18369-4. The water content can be measured by the following method: Take a few lenses that have been hydrated and swelled, place the lenses on a damp cloth and gently wipe to remove excess water, and place the lenses in the sample pan on the balance. Weigh and record the weight of the lens before dehydration (a), put the lenses in a constant temperature and humidity oven for several hours, weigh the weight of the dehydrated lens (b), and then weigh the lens before dehydration (a) Subtract the weight of the lens after dehydration (b), and divide it by the weight of the lens before dehydration (a), and the calculated value is the water content of the lens body. The water content can be expressed as a percentage. The hydrogel lenses made according to the following example 1 to 4 all have a moisture content of 10% to 75% (w/w), specifically 32% to 70%, more specifically 36% to 65 %between.

The calculation formula of water content is: Water content (%) = Lens body wet weight (a)-Lens body dry weight (b) x 100% Lens body wet weight (a)

In addition, it should be noted that in the following table 1, the base curve (BC) and diameter (DIA) of the lens are measured by a contact lens optical measuring instrument. The central thickness (CT) of the lens is measured by a lens thickness detector. The refractive index of the lens is measured by an Abbe refractiometer. The light transmittance of the lens is obtained by measuring the visible light transmittance value using an ultraviolet spectrometer.

[Comparative Example 1 and Exemplary Examples 1 to 4]

The following Table 1 lists the water gel compositions of Comparative Example 1 (control group) and Exemplary Examples 1 to 4, and the test results of their physical and chemical properties. The above exemplary examples are only examples, and are not intended to limit the present invention.

Specifically, the hydrogel compositions of Comparative Example 1 and Exemplary Examples 1 to 4 all include: 85.28 parts by weight of hydrophilic monomer, 0.88 parts by weight of crosslinking agent, 0.50 parts by weight of initiator, and 1.11 parts by weight The UV blocking monomer, 12.21 parts by weight of co-solvent and 0.02 parts by weight of dye. Among them, Comparative Example 1 is the control group, which did not add rotaxane molecules, while Exemplary Example 1 to Exemplary Example 4 added different weight parts of rotaxane molecules. Among them, among the rotaxane molecules of Exemplary Examples 1 to 4, cyclodextrin is used as the cyclic molecule, and polyethylene glycol (PEG) is used as the linear molecule.

[Table 1] Comparative example 1 (control group) Example 1 Example 2 Example 3 Example 4 Rotaxane molecule (parts by weight) 0 4.00 5.10 6.90 1.35 Cyclic molecule: Linear molecule (weight ratio) 0 20.5:1 11.9:1 8.80:1 30.6:1 Base arc (mm) 8.425 8.450 8.425 8.500 8.475 Center thickness (mm) 0.082 0.078 0.090 0.086 0.085 Diameter (mm) 14.15 14.15 14.10 14.05 14.15 Refractive index 1.4044 1.4054 1.4051 1.4044 1.4049 Penetration rate (%) 98.707 99.027 98.797 98.931 99.125 Water content (%) 57.21 56.82 57.23 56.82 57.10 Dynamic contact angle (degrees) 30.45 26.49 25.95 29.33 25.66 Elongation (%) 320 340 320 330 350 10 minutes of atmospheric dehydration (%) 12.40 10.88 10.95 10.85 10.78 30 minutes of atmospheric dehydration (%) 34.04 30.35 31.25 32.20 30.65 60 minutes of atmospheric dehydration (%) 52.21 50.09 50.55 50.75 51.52 Lubricity (1-10 points) 5.0 5.0 4.9 5.1 5.0 Water extraction (%) 0.21 0.11 0.08 0.75 0.10 Hexane extraction (%) 0.09 0.12 0.09 0.09 0.11

It can be seen from Table 1 that the hydrogel lens with rotaxane molecules added (Example 1 to Example 4) is compared with the hydrogel lens without rotaxane molecule (Comparative Example 1, control group), with rotaxane added The molecular hydrogel lens has a low dynamic contact angle. In other words, contact lenses with rotaxane molecules have better wettability.

It can be seen from Table 1 that the hydrogel lens with rotaxane molecules added (Example 1 to Example 4) is compared with the hydrogel lens without rotaxane molecule (Comparative Example 1, control group), with rotaxane added Molecular hydrogel lenses have a lower atmospheric dehydration rate. In other words, the drying rate of contact lenses added with rotaxane molecules is relatively slow, so the wearer is less likely to feel the lens body dry.

It can be seen from Table 1 that the hydrocolloid lenses added with rotaxane molecules (Example 1 to Example 4) are on the surface of the basic physical and chemical properties of the contact lens (such as: base curve, center thickness, diameter, refractive index, elongation , Penetration, lubricity) are no less than the hydrogel lens without adding rotaxane molecules (Comparative Example 1, control group). That is to say, when the rotaxane molecule is introduced into the hydrocolloid lens, it not only has better wettability, lower atmospheric dehydration rate, potential for loading and slow release of active ingredients, but also it can still maintain the requirements of contact lens lenses. Characteristics.

Furthermore, the weight of the water extract and the weight of the n-hexane extract of the hydrogel lenses in Table 1 are very low, which shows that the curing of the hydrogel composition is quite complete.

[Clinical Evaluation of Contact Lens Wearing Condition]

The following are two commonly used clinical assessment methods for contact lens wearing conditions in practical operations, including questionnaire interviews and the height of tears.

Questionnaire interview (subjective test): Use the contact lens questionnaire to ask about the symptoms of wearing, the frequency of occurrence, and the feeling of wearing for a long time to understand the actual condition of the wearer.

The evaluation method of the questionnaire interview is to immerse the hydrogel lenses made in Comparative Example 1 and Exemplary Examples 1 to 4 in Table 1 in a contact lens preservation solution containing menthol to carry the menthol molecule. , And then take out these contact lenses. Next, select 5 subjects to perform a comprehensive evaluation test. The test was completed by 5 subjects aged 25 to 40 years old, and all 5 subjects did not know what they were wearing. The test was conducted in the case of the lens group and without knowing the added ingredients of the drug, and the score was 1 to 10 points. The higher the score, the stronger the feeling of the test item. The comprehensive results of the 5 subjects are shown in Table 2.

[Table 2] Evaluation item Point in time Comparative example 1 Example 1 to 4 Cool feeling When I first put it on 6 6.2 to 6.5 30 minutes after wearing 2.8 3.8 to 4.4 1 hour after wearing 1.2 2.0 to 2.5 2 hours after wearing 0.6 1.1 to 1.7 Dryness When I first put it on 2.2 1.8 to 2.0 4 hours after wearing 3.2 2.0 to 2.2 Foreign body sensation in eyes When I first put it on 1.8 1.5 to 1.7 4 hours after wearing 3.4 1.7 to 2.0

Tear Meniscus Height: Observe with a corneal topography device and measure the height of the tear river by observing the tear layer to determine whether the subject’s tears are sufficient. The height of a normal person's tear channel is about 0.25 mm. If the measured height is lower than this value, it means that there is insufficient tear secretion.

The method for evaluating the height of the tear river is to immerse the hydrogel lenses made in Comparative Example 1 and Exemplary Examples 1 to 4 in Table 1 in a contact lens preservation solution containing menthol to perform menthol molecular analysis. Carry on, and then take out these contact lenses. Next, select 5 subjects, and determine the amount of tear secretion of the subjects by measuring the height of the tear river. When menthol continues to work, it will stimulate tear secretion. The test was completed by 5 subjects aged between 25 and 40 years old, and all 5 subjects did the test without knowing the lens set and the added ingredients of the drug. The combined results of 5 subjects are shown in Table 3.

[table 3] Evaluation item Point in time Comparative example 1 Example 1 to 4 Tear River Height (mm) When I first put it on 0.300 0.310 to 0.325 Wear it for 2 hours 0.240 0.282 to 0.298 4 hours after wearing 0.230 0.265 to 0.272

[Beneficial effects of the embodiment]

One of the beneficial effects of the present invention is that the water gel composition and the water gel lens for preparing the water gel lens provided by the present invention can adopt the technical solution of introducing rotaxane molecules into the water gel composition, So that the final formed hydrocolloid lens can have the effect of loading and slow-release of active ingredients.

It is worth mentioning that when the rotaxane molecule is introduced, the hydrocolloid lens of the present invention not only has the effect of loading and slow-release of the active ingredient, but also can maintain the required characteristics of the contact lens, such as the lens base curve ( base curve, BC), lens center thickness (CT), lens diameter (diameter, DIA), refractive index, visible light transmittance or dynamic contact angle... etc.).

The content disclosed above is only the preferred and feasible embodiments of the present invention, and does not limit the scope of the patent application of the present invention. Therefore, all equivalent technical changes made using the description and schematic content of the present invention are included in the application of the present invention. Within the scope of the patent.

100: Water glue composition 1: Rotaxane molecule 11: Linear molecule 12: cyclic molecule 2: Hydrophilic monomer

Fig. 1 is a schematic diagram of a rotaxane molecule dispersed in a hydrogel composition according to an embodiment of the present invention.

FIG. 2 is a schematic diagram of cyclic molecules stacked on each other according to an embodiment of the present invention.

100: Water glue composition 1: Rotaxane molecule 11: Linear molecule 12: cyclic molecule 2: Hydrophilic monomer

Claims (38)

A hydrogel composition comprising: a hydrophilic monomer of 60 parts by weight to 99.85 parts by weight; a crosslinking agent of 0.01 parts by weight to 1 part by weight; and an initiator of 0.01 parts by weight to 2 parts by weight And a rotaxane molecule (rotaxane), which is 0.1 parts by weight to 15 parts by weight; wherein the rotaxane molecule includes at least one cyclic molecule and at least a linear chain penetrating through at least one of the cyclic molecules in a string Molecule; wherein, in the rotaxane molecule, the average molecular weight of the linear molecule is between 2,000 to 20,000, and the rotaxane molecule does not contain any used to block the cyclic molecule from the A slopper/capping group in which both ends of a linear molecule are separated. The water gel composition according to claim 1, wherein the rotaxane molecule is 0.1 to 12 parts by weight. The water gel composition according to claim 2, wherein the rotaxane molecule is 0.5 to 8 parts by weight. The hydrogel composition according to claim 1, wherein, in the rotaxane molecule, the weight ratio of at least one cyclic molecule to at least one linear molecule is between 1:1 and 50 : Between 1. The hydrogel composition according to claim 4, wherein, in the rotaxane molecule, the weight ratio of at least one cyclic molecule to at least one linear molecule is between 5:1 and 35 : Between 1. The hydrogel composition according to claim 1, wherein at least one of the cyclic molecules is cyclodextrin or a derivative thereof. The hydrogel composition according to claim 6, wherein the cyclodextrin is selected from the group consisting of α-cyclodextrin (α-cyclodextrin), β-cyclodextrin (β-cyclodextrin), and γ-cyclodextrin ( γ-cyclodextrin), hydroxypropyl-β-cyclodextrin (hydroxypropyl-β-cyclodextrin), (2-hydroxypropyl)-γ-cyclodextrin ((2-hydroxypropyl)-γ-cyclodextrin), sulfobutylether-β-cyclodextrin (sulfobutylether-β-cyclodextrin) And at least one of the material group consisting of methyl-β-cyclodextrin (methyl-β-cyclodextrin). The hydrogel composition according to claim 1, wherein at least one of the cyclic molecules is crown ether or a derivative thereof. The hydrogel composition according to claim 8, wherein the crown ether is selected from 12-crown-4 (12-crown-4), 15-crown-5 (15-crown-5), 18-crown -6 (18-crown-6), benzo-18-crown-6 (benzo-18-crown-6), benzo-15-crown-5 (benzo-15-crown-5), dicyclohexyl-18 -Crown-6 (dicyclohexyl-18-crown-6), 2-(hydroxymethyl)-12-crown-4-ether (2-(hydroxymethyl)-12-crown-4-ether), 2-(hydroxymethyl)-12-crown-4-ether Base)-15-crown-5-ether (2-(hydroxymethyl)-15-crown-5-ether) and 2-(hydroxymethyl)-18-crown-6-ether (2-(hydroxymethyl)-18- crown-6-ether) at least one of the material groups. The hydrogel composition according to claim 1, wherein at least one of the linear molecules is selected from polyethylene glycol (PEG), polyvinyl alcohol (PVA) and polypropylene glycol (polypropylene glycol). At least one of the material group consisting of glycol, PPG). The water glue composition according to claim 10, wherein the polyethylene glycol has a structure as shown in formula (1):

Polyvinyl alcohol has a structure like formula (2):

Polypropylene glycol has a structure like formula (3):

Among them, n is a positive integer greater than 4. The water gel composition according to claim 11, wherein the average molecular weight of the linear molecule is between 200 and 20,000. The water gel composition according to claim 1, wherein the hydrophilic monomer is 68.88 parts by weight to 99.85 parts by weight. The hydrogel composition according to claim 1, wherein the hydrophilic monomer is selected from N-vinyl pyrrolidone (NVP), 2-hydroxyethyl methacrylate (2-hydroxyethyl methacrylate) methacrylate (HEMA), methacrylic acid (MAA), methyl methacrylate (MMA), acrylic acid (AAc), N,N-dimethylacrylamide (N,N- dimethyl acrylamide, DMA), 2,3-dihydroxypropyl methacrylate (GMMA), N,N-dimethyl acrylamide (N,N -dimethyl methacrylamide) and at least one of the material group consisting of N-vinyl-N-methyl acetamide (N-vinyl-N-methyl acetamide). The water gel composition according to claim 1, wherein the hydrophilic monomer has a vinyl group, an acetyl group, an acrylic group or an acrylic group. The water gel composition according to claim 1, wherein the crosslinking agent is 0.04 parts by weight to 0.57 parts by weight. The water glue composition according to claim 1, wherein the crosslinking agent is selected from the group consisting of ethylene glycol dimethacrylate (ethylene glycol dimethacrylate). dimethacrylate), diethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetravinyl glycol dimethacrylate Ester (tetraethylene glycol dimethacrylate), allyl methacrylate, triethylene glycol dially ether, tetraethylene glycol dially ether At least one of the material group consisting of tetraethylene glycol dially ether and 1,1,1-trimethylolpropane trimethacrylate. The hydrogel composition according to claim 1, wherein the initiator is a photoinitiator, and the photoinitiator is 0.05 to 0.72 parts by weight. The hydrogel composition according to claim 18, wherein the photoinitiator is selected from the group consisting of bis(1-(2,4-difluorophenyl)-3-pyrrolyl) titanocene (bis(2 ,6-difluoro-3-(1-hydropyrro-1-yl)-phenyl)titanocene), phenylbis(2,4,6-trimethylbenzoyl)phosphine oxide (phenylbis-(2,4,6 -trimethylbenzoyl)-phosphine oxide) and 2-hydroxy-2-methyl-1-phenyl-1-porpanone (2-hydroxy-2-methyl-1-phenyl-1-porpanone) at least one of them. The water gel composition according to claim 1, which further comprises: an ultraviolet light blocking monomer, and the ultraviolet light blocking monomer is 0.34 parts by weight to 1.68 parts by weight. The hydrogel composition according to claim 20, wherein the ultraviolet light blocking monomer is selected from the group consisting of a monomer having benzophenone and a monomer having benzotriazole At least one of the material groups. The water glue composition according to claim 1, further comprising: a co-solvent, and the co-solvent is 4.33 parts by weight to 12.67 parts by weight. The hydrogel composition according to claim 22, wherein the co-solvent is selected from the group consisting of glycerol, isopropyl alcohol, n-butanol, and t-butanol (t-butanol). butanol), t-amyl alcohol (t-amyl alcohol) and n-hexanol (n-hexanol) composed of at least one of the material group. The water gel composition according to claim 1, further comprising: a dye, and the dye is 0.002 parts by weight to 0.039 parts by weight. The hydrogel composition according to claim 24, wherein the dye is selected from the group consisting of reactive blue 19 (disodium,1-amino-9,10-dioxo-4-[3-(2-sulfonatooxyethyl sulfonyl)anilino]anthracene -2-sulfonate), Sudan III (1-[4-(Phenylazo)phenylazo]-2-naphthol, Sudan III), indigo (2,2'-Bis(2,3-dihydro-3-oxoindolylidene), Indigo ) And quinoline yellow (disodium 2-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)quinolone-6,8-disulfonate, Quinoline yellow) at least in the material group one. The water gel composition according to claim 1, wherein the hydrophilic monomer has an acryl group, and the weight ratio of the rotaxane molecule to the hydrophilic monomer is between 1:6 to Between 1:94. The hydrogel composition according to claim 26, wherein the cyclic molecule in the rotaxane molecule is α -cyclodextrin ( α -cyclodextrin) or β -cyclodextrin ( β -cyclodextrin), and The weight ratio of the rotaxane molecule to the hydrophilic monomer is between 1:11 and 1:54. The requested item aqueous gum composition according to 26, wherein the rotaxane molecule of the cyclic molecule is hydroxypropyl - β - cyclodextrin (hydroxypropyl- β -cyclodextrin), and the rotaxane molecule The weight ratio to the hydrophilic monomer is between 1:17 and 1:86. The requested item aqueous gum composition according to 26, wherein the rotaxane molecule of the cyclic molecule (2-hydroxypropyl) - γ - cyclodextrin ((2-hydroxypropyl) - γ -cyclodextrin ), and the weight ratio of the rotaxane molecule to the hydrophilic monomer is between 1:19 to 1:94. The water gel composition according to claim 1, wherein the average molecular weight of the linear molecule is not less than 4,000. The hydrogel composition according to claim 1, wherein, in the rotaxane molecule, the outer periphery of the cyclic molecule has a hydrophilic functional group, and the inner side of the cyclic molecule has a hydrophobic cavity structure; Wherein, the rotaxane molecule can interact with the hydrophilic monomer through the hydrophilic functional group on the periphery of the cyclic molecule, so that the rotaxane molecule is dispersed in the hydrogel composition. The hydrogel composition according to claim 1, wherein the linear molecules of the rotaxane molecule are dispersed in the hydrophilic monomer in a tortuous form, and at least one of the cyclic molecules The number of the cyclic molecules is multiple, and a plurality of the cyclic molecules are arranged on the linear molecules in a series connection. The hydrogel composition according to claim 32, wherein the plurality of cyclic molecules connected in series and the plurality of adjacent cyclic molecules in series can be attracted to each other by the force of hydrogen bonds, and Arranged on top of each other. The hydrogel composition according to claim 32, wherein a plurality of the cyclic molecules connected in series are heads to heads and tails to tails on the linear molecules. Arranged in a way. A water gel lens, comprising: a lens body formed by the water gel composition according to any one of claims 1 to 34. The hydrocolloid lens according to claim 35, wherein the rotaxane molecules are distributed on at least a concave arc surface or a convex arc surface of the lens body to form a rotaxane component Sub-layer, and the rotaxane molecule is configured to carry an active ingredient. The hydrocolloid lens according to claim 36, wherein the active ingredient comprises: menthol, camphor, borneol, potassium chloride, lysozyme hydrochloride, potassium glycyrrhizinate, 6-aminocaproic acid, zinc sulfate, vitamin B2, Sodium nitrogen sulfonate, sulfamethoxazole, pranoprofen, naphazoline, tetrahydrozoline, chlorobutanol, ephedrine hydrochloride, phenylephrine, vitamin E, potassium L-aspartate , Magnesium Aspartate, Chondroitin Sulfate, Neosmine Methyl Sulfate, Arginine, Vitamin B12, Vitamin B5, Vitamin B6, Vitamin A, Taurine, Diphenhydramine, Chlorpheniramine, Trix At least one of nilast, boric acid, glycerin, hyaluronic acid, polyol, and allantoin. The water gel lens according to claim 35, wherein a refractive index of the lens body is between 1.315 and 1.598, and a light transmittance of the lens body is not less than 90 %, a water content of the lens body is between 10% and 75% (w/w), a dynamic contact angle of the lens body is not greater than 80 degrees, and An elongation of the lens body is between 250% and 380%.

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