TWI729860B - Measuring method and measuring device for detecting characteristic value of mental stress of brain - Google Patents

Abstract

A measuring device for detecting the characteristic value of mental stress in the brain, for analyzing the brain magnetic wave data generated by the activity of the amygdala neurons of the brain of a subject. The measuring device includes: at least one storage element for storing at least one set of judgment models ; At least two external sensory stimulators, one for presenting visual cues of the subject, and one connected to the subject’s skin and outputting pain-inducing irritating electrical signals; a plurality of measuring devices, sampling and extracting brain The amygdala responds to the brain magnetic wave signal induced by an external stimulus, where the brain magnetic wave signal includes at least one paired brain wave data and at least one unpaired brain wave data; a processing element for distinguishing and calculating the brain wave signal to obtain a brain mental stress characteristic The value is compared with the above judgment model to generate a comparison information and output.

Description

Measuring method and measuring device for detecting characteristic value of mental stress of brain

The present invention relates to a measuring method and a measuring device for detecting the brain, especially a measuring method and a measuring device for detecting the characteristic value of mental stress in the brain.

Fibromyalgia, also known as "mysterious pain", is a syndrome with complex clinical manifestations, which may be related to the imbalance of neurotransmitters in the central nervous system. The main symptoms of the patient are chronic generalized pain and tenderness, as well as other systemic symptoms and comorbidities, including: fatigue, insomnia, headache, gastrointestinal symptoms, depression, anxiety, etc. These annoying symptoms often affect the quality of life of patients and cause severe disability.

However, the pathogenic mechanism of fibromyalgia is still unclear, and patients with this disease are not able to obtain specific data from any currently known tests to assist medical staff in confirming their condition or identifying its severity. degree. Even if the patient is estimated to have reached 2 to 4% of the general population, the cause of this disease has not yet been determined. The first task of diagnosis is to exclude other diseases with similar symptoms, such as inflammatory/degenerative joints. Inflammation, inflammatory muscle disease, thyroid disease, vitamin D deficiency, infection... etc. At present, it can only be speculated that it may be related to the imbalance of neurotransmitters in the central nervous system responsible for regulating pain, including: serotonin, dopamine, catecholamine... etc. In fibromyalgia, the imbalance of these neurotransmitters may change the excitability of the central nerve, making the nerve's response to peripheral pain too sensitive or intense.

To put it more simply, this kind of pain often exists in the patient itself and has a subjective component. For the patient, the pain is real, but in the eyes of others, it may be considered as a disease-free groan, which is imagined by oneself. However, at present, researchers have been able to determine from imaging examinations such as functional MRI that the brains of patients with fibromyalgia are really more sensitive to pain, and the pain is amplified, rather than simply "princess disease." Epidemiological studies have shown that the prevalence rate of fibromyalgia in the general population is 2-4%, most of which are females. The ratio of female to male is about 7:1, and the age of prevalence is about 30-50 years old. But it can happen in all age groups.

Since this type of disease is usually prone to recurrence under conditions of excessive mental stress, if the mental stress of the brain of the patient or potential patient can be measured specifically, it can also be used as objective supporting data in the medical process. However, the current scientific detection of mental stress is limited to the subjective statement of the test subject, or the tester issues a questionnaire for the test subject to fill out, and then the tester performs analysis and scoring. It is impossible to objectively and quickly know the test subject’s mental stress The size. Therefore, how to establish a measurement method and measurement device for detecting the characteristic values of mental stress in the brain, so as to provide an objective numerical standard for quantitative measurement of mental stress, and to make this measurement easy to operate with appropriate equipment and equipment. Information acquisition is convenient, fast, and has a high success rate. These are the most urgent problems in medical instruments and equipment that need to be resolved.

In view of the above-mentioned problems, the main purpose of the present invention is to provide a method for measuring the characteristic value of mental stress in the brain, using external stimulation, and then measuring the characteristic value of the brain magnetic wave of the amygdala of the brain under stimulation, so as to obtain objective and specific data. Evaluate the basis for judging the magnitude of the subject's mental stress.

Another object of the present invention is to provide a measurement of characteristic values of mental stress in the brain The method, through the simple and scientific measurement procedure, makes the measurement of the characteristic value of the brain magnetic wave more convenient, not only easy to obtain objective data, but also has a higher success rate.

Another object of the present invention is to provide a measurement device for the characteristic value of mental stress of the brain, which can stimulate the subject under test through the body of the wearable device, capture the brain magnetic wave signal, and connect to the cloud server for subsequent analysis and calculation. Processing to achieve the purpose of numerical quantification.

Yet another object of the present invention is to provide a measurement device for the characteristic value of mental stress in the brain. By comparing the characteristic value of the brain wave of each subject with the judgment model, the comparison information with objective significance is obtained to assist Determine the amount of mental stress of the subject.

In order to achieve the above objective, the present invention discloses a measurement method for detecting the characteristic value of mental stress of the brain for detecting the mental stress of a test subject in a magnetic shielded space. The measurement method is to measure a certain number of health tests in advance. The subject’s mental stress characteristic values are used to establish a judgment model. The above measurement includes providing multiple paired stimuli and unpaired stimuli randomly interspersed between the paired stimuli to the subject, and real-time capture of the brain's amygdala nerve activity The generated brain magnetic wave data; among them, the paired stimulus is accompanied by a painful stimulating electrical signal after a related visual stimulus. The above-mentioned related visual stimulus will make the subject think of the subsequent stimulating electrical signal, and the non-paired stimulus is performed at one time The related visual stimulus is followed by a non-irritating blank signal; here, the brain magnetic wave data acquired by the amygdala of the subject’s brain in response to the paired stimulus is defined as the paired brain magnetic wave data, and the data acquired in response to the unpaired stimulus The acquired electroencephalogram data is defined as unpaired electroencephalogram data, and then the unpaired electroencephalogram data is calculated to obtain the characteristic value of the subject’s mental stress; the measurement method includes the following steps: a). Provide multiple pairs of the aforementioned pairings in sequence The stimulus and the unpaired stimulus randomly interspersed between the paired stimuli for a plurality of times are given to a test subject, and the plural unpaired electroencephalogram data of the test subject is captured in real time according to the above sequence; b). The above sequence distinguishes the plurality of acquisitions. The complex unpaired brain wave data acquired in the first half of the number of times is the early response data, and the complex unpaired brain wave data acquired in the second half of the number of times is the late response data; c) . Calculate the unpaired electroencephalogram data in the early response data to obtain an early unpaired electroencephalogram data, and calculate the unpaired electroencephalogram data in the late response data to obtain a late unpaired electroencephalogram data D). Calculate the aforementioned early unpaired electroencephalogram data and the aforementioned late unpaired electroencephalogram data to obtain a characteristic value of cerebral mental stress; and e). Compare the characteristic value of mental stress of the brain with the above judgment model to generate a The comparison result, and output the above comparison result.

On the other hand, in order to perform the above measurement accurately and efficiently, the present invention discloses a corresponding measurement device for detecting the characteristic value of mental stress in the brain, which stores at least one judgment model, and the measurement device is provided in a magnetic shielded space To detect the mental stress of the brain of a test subject, the measurement method is to measure the characteristic values of the mental stress of a certain number of healthy subjects in advance to establish a judgment model. The above measurement includes providing multiple paired stimuli and randomly interspersed between the paired stimuli. The non-paired stimulus is given to the subject, and the brain magnetic wave data of the amygdala of the brain is captured in real time. Among them, the paired stimulus is accompanied by a stimulating electrical signal after a related visual stimulus, and the above-mentioned related visual stimulus will cause the subject to be tested. The person thinks of the subsequent stimulating electrical signal, while the non-paired stimulus is accompanied by a non-irritating blank signal after a related visual stimulus; here, the amygdala of the subject’s brain responds to the brain captured by the paired stimulus. Magnetic wave data is defined as matched brain wave data, and the brain wave data captured in response to unpaired stimuli is defined as unpaired brain wave data, and then the unpaired brain wave data is calculated to obtain the characteristic value of the subject’s mental stress. The measurement device includes: a server including a processing element and a storage element for storing the above-mentioned judgment model; a display that is actuated by the above-mentioned server to provide the above-mentioned visual stimulation; An electrical stimulator that is actuated by a server to provide the above-mentioned stimulating electrical signal; and

An electroencephalogram measuring device is set on the head of the subject to capture unpaired electroencephalogram data of the amygdala of the subject’s brain in response to the unpaired stimulus, and output to the server, and the processing The component distinguishes the complex unpaired electroencephalogram data acquired in the first half of the plurality of acquisitions as early response data and the complex unpaired electroencephalogram data acquired in the second half of the acquisitions as late response data according to the above sequence. Then calculate the mathematical average of the foregoing early response data to obtain an early unpaired brainwave data, and calculate the mathematical average of the foregoing late response data to obtain a late unpaired brainwave data, and subtract the above-mentioned early unpaired brainwave data. After removing the above-mentioned unpaired brain wave data, a characteristic value of mental stress of the brain is obtained.

Compared with the prior art, the method and device for measuring characteristic values of mental stress of the brain disclosed in the present invention uses paired stimulating electrical signals to perform external stimulation, and captures the brain magnetic wave data of the amygdala of the subject under test. On the one hand, objective data can be obtained to avoid the uncertainty that had to be judged based on the subjective statements of patients in the past; and with a simple wearable device, the brain magnetic wave signal can be easily obtained and the measurement success rate can be improved;

In particular, the information obtained is accurately quantified, so that patient data can be compared and analyzed before and after, so that all the history records of each patient can be compared by themselves, and the treatment effect can be judged; patients can also be statistically analyzed to confirm various details. The actual effect of treatment methods or drugs provides scientific and specific information to effectively assist medical progress.

The measurement device of the present invention is connected to multiple measurement devices through a server in the cloud, which can not only process remotely, or calculate the brain magnetic wave signals transmitted by multiple measurement devices at the same time, but also can further study the measurement data for more extensive research. data of.

1. 1': Measuring device for characteristic values of mental stress in the brain

2, 2’: Magnetic Brain Wave Apparatus

3. 3’: Server

31, 31’: Processing element

32: storage components

4: display

5. 5’: Stimulator

6: Measuring instrument

61, 61’: Electroencephalogram measuring element

612: Cooler

62: ECG measuring element

63: EOG signal measuring component

7: Input unit

8, 8’: Subject under test

9’: Input display

10’: Network transmission unit

101~109, 101’~110’: steps

FIG. 1 is a schematic diagram of the device architecture of the first preferred embodiment of the brain stress characteristic value measurement device of the present invention.

Fig. 2 is a schematic diagram of the implementation of the device for measuring characteristic values of mental stress of the brain in the embodiment of Fig. 1.

Fig. 3 is a flowchart of establishing a judgment model of the first preferred embodiment of the brain mental stress measurement device in this case.

FIG. 4 is a schematic diagram of the device architecture of the second preferred embodiment of the brain stress characteristic value measurement device of the present application.

Fig. 5 is a schematic diagram of the implementation of the device for measuring characteristic values of mental stress of the brain in the embodiment of Fig. 4.

FIG. 6 is a flowchart of the evaluation steps of the brain mental stress characteristic value of the second preferred embodiment of the brain mental stress characteristic value measuring device of the present application.

The following specific examples illustrate the implementation of the present invention. Those familiar with the art can easily understand the advantages and effects of the present invention from the contents disclosed in this specification.

The structure, ratio, size, etc. shown in the drawings in this specification are only used to match the disclosure content of the specification for the understanding and reading of those who are familiar with the art, and are not used to limit the implementation of the present invention. Any structural modification, size adjustment, or change in the proportional relationship, without substantial changes to the technical content, shall also be regarded as the scope of the implementation of the present invention.

The first preferred embodiment of the device 1 for measuring the characteristic value of mental stress of the brain of the present invention is shown in Figs. 1 and 2, mainly by the measurement of cerebral magnetic waves provided in the environmental device 2 which is a magnetic shielded measurement room, for example. In this case, the magnetoencephalography (MEG) is used as the core of the measurement, and with the example explained as the server 3 of the workstation computer, and the receiver The server 3 outputs a signal to display the image on the LCD screen as the display 4, the pulse electric shock driven by the server 3 is used as the stimulator 5, and the measuring device 6 is included. For example, it is equipped with complex superconducting quantum interference. The electroencephalogram measuring element 61 of the helmet of the superconductive quantum interference device (SQUID) is an electrocardiogram measuring element 62 such as an electrocardiograph, and an electrooculogram signal measuring element 63 such as an EOG machine. Among them, the stimulator 5 has a concentric circular electrical stimulation patch attached to the calf skin of the subject to be tested for mental stress sampling. Since the superconducting quantum interference element of the electroencephalogram measurement element 61 must be in an extremely low temperature and magnetically shielded environment to correctly capture electroencephalogram data, the electroencephalogram measurement element 61 also includes a set of coolers 612. Since the magnetic wave does not need to be transmitted by a medium, the measuring element does not need to be closely attached to the head of the object under test.

The input unit 7 can be used to input the parameter settings of the external sensory stimulator 5 and the personal information of the tested object 8, such as name, age, height, weight or blood pressure value, etc., so that the processing element 31 can further calculate the test object 8’s Personal information is included in the calculation to increase other reference data for comparison information.

First of all, please also refer to the flow chart of establishing the judgment model in Figure 3. In this example, the judgment model consists of accumulating numerous methods such as the Perceived Stress Scale (PSS), etc., to confirm in advance the normal mental stress. Established based on the measurement result data of the test subject, by accumulating a sufficient number of maternal samples to build a judgment model for subsequent comparisons as a reference, assisting in determining the level of mental stress of the new subject, and providing objective comparison data. .

Step 101: Start the complex electroencephalogram measuring element 61, the electrocardiogram measuring element 62, and the electrooculogram signal measuring element 63 of the measuring device 6, and start to continuously extract the amygdala of the subject’s brain at a sampling frequency of, for example, 600 Hz. The magnetic brain wave data, electrocardiogram data, and electrooculogram data emitted by external stimulation, and the magnetic brain wave data, electrocardiogram data and storage Stored in the storage component 32 of the server 3.

In step 102, before the test officially starts, the display provides a visual signal of the test object with a duration of, for example, 200 milliseconds, as a conditioned stimulus (CS), and informs the subject that the visual signal is for example 300 In milliseconds, a painful and irritating electrical signal will be given to the subject. In this example, the relevant visual signal is, for example, a picture of a lightning bolt, which makes the subject automatically associate the subsequent irritating electrical signal.

At step 103, the test officially starts, and the display 4 provides the relevant visual signal (CS) of the object under test with the above-mentioned duration of 200 milliseconds. And following step 103, in step 104, with a random probability of, for example, 50%, the stimulator 5 is instructed to apply a stimulus electrical signal as an unconditioned stimulus (UCS) to the subject through the electrical stimulation patch, The irritant electrical signal in this example is a constant square wave current of 0.2 milliseconds to cause a irritant electrical signal of moderate pain intensity on the pain evaluation form to the subject; another 50% probability is no stimulation without applying unconditional stimuli Two kinds of signals, such as the sexual blank signal, are implemented randomly according to the above-mentioned probability. Since part of the lightning symbols will be accompanied by irritating electrical signals, the lightning symbol screen is defined as a disgusting stimulus. Here, the combination of a disgusting stimulus and an irritating electrical signal is further defined as a set of paired stimuli; and After the aversive stimulus, the combination of accompanied by non-irritating blank signals is defined as a set of unpaired stimuli; the number of occurrences of paired stimuli and unpaired stimuli is exactly the same.

Step 105, repeat the above steps 103~104 continuously for 30 times of paired stimulation and 30 times of unpaired stimulation; here, the brain magnetic wave data captured by the amygdala of the subject’s brain in response to the paired stimulation is defined as The paired electroencephalogram data, and the electroencephalogram data acquired in response to the unpaired stimulus is defined as unpaired electroencephalogram data, and the electroencephalogram data of 30 unpaired stimuli is taken as the early response data. Step 106, repeat the above steps 103~104 continuously. 30 times of paired stimulation and 30 times of unpaired stimulation, and the brain magnetic wave data of 30 times of unpaired stimulation are taken as the later response data. Of course, if any of the above-mentioned unpaired electroencephalogram data is contaminated by ECG data or EOG data, it will be excluded and not included in the calculation.

Step 107: Use the processing element 31 of the server 3 to calculate the mathematical average of the unpaired electroencephalogram data in the early response data to obtain the early unpaired electroencephalogram data, and calculate the unpaired electroencephalogram data in the late response data The mathematical average of, in order to obtain the later unpaired brain wave data. Then in step 108, the processing component 31 of the server 3 subtracts the unpaired electroencephalogram data from the early unpaired electroencephalogram data to obtain the characteristic value of mental stress of the brain and store it in the storage component 32 of the server 3. .

Repeat the above test for different subjects, and gradually accumulate a certain number of subjects’ brain mental stress characteristic values and store them in the storage element 32. It can be calculated that people with different levels of mental stress are compared in the early and late stages, and there is no actual stimulus. The degree of change in the fear subsidence of the lightning symbol of the sexual signal is to complete step 109 to establish a judgment model. As for patients with fibromyalgia, compared with those without abnormal brain stress, their fear subsidence is significantly different, that is, they have a higher mental stress measured specifically and quantitatively.

Please refer to FIG. 4 to FIG. 6, the second preferred embodiment of the present invention is used for the measurement device of the characteristic value of mental stress of the brain. The similarities between this embodiment and the previous preferred embodiment will not be repeated. The brain magnetic wave measuring element 61' in this example is illustrated as including a helmet equipped with a plurality of optically pumped magnetometers (OPM) as the element for acquiring brain magnetic wave signal data. Since the optical pumped magnetic field meter does not need to have high sensitivity in an ultra-low temperature environment, it can be installed on a light and fit helmet made by 3D printing to match the 8'head profile of the object under test. Cooler that takes up a lot of space. Therefore, the measurement device for the characteristic value of mental stress of the brain in this example can be Set to achieve mobility.

Therefore, in this example, the environmental device 2', which is illustrated as a magnetically shielded compartment, is constructed on a modified bus, and the brain stress characteristic value measurement device 1'is installed in it, and the device space is simplified to improve mobility. So in this example. The input unit and the display are also combined and interpreted as an input display 9'with a touch display screen, and the data captured by the measuring instrument is also uploaded to the server 3'in the cloud through the network transmission unit 10' for calculation and judgment, multiple units The data captured by the brain stress characteristic value measuring device 1'is shared by a cloud server for centralized calculation and judgment, which can greatly reduce the cost of purchasing a computing server and occupy space for refitting buses. In this way, the quantitative reference test of mental stress can be introduced into rural areas, lower the threshold of psychiatric treatment, and provide more accurate quantitative reference standards.

In this example, the test subject 8'is a suspected patient who has undergone mental stress measurement, and the test subject 8'also receives the measurement of the above step 101' to step 108' to obtain the characteristic value of the brain's mental stress. Then, proceed to step 110', by using the processing component 31' of the cloud server 3'to compare the brain mental stress characteristic value of the subject 8'with the above judgment model, and then display the comparison result on the input display 9' Output.

However, the above are only preferred embodiments of the present invention, and cannot be used to limit the scope of implementation of the present invention. All simple equivalent changes and modifications made in accordance with the scope of the patent application of the present invention and the contents of the specification should still be used. It falls within the scope of the present invention. After the description of the preferred embodiments of the present invention, those familiar with this technical field should understand that this case is indeed a novel, progressive, and industrially applicable invention, which has deep development value.

1: Measuring device for characteristic values of mental stress in the brain

2: Electroencephalography

3: server

31: Processing components

32: storage components

4: display

5: Stimulator

6: Measuring instrument

61: Electroencephalogram measuring element

612: Cooler

62: ECG measuring element

63: EOG signal measuring component

8: Subject under test

Claims (10)

A measurement method for detecting the characteristic values of mental stress in the brain for detecting the mental stress of a subject in a magnetic shielded space. The measuring method is to measure the characteristic values of mental stress in the brain of a certain number of healthy subjects in advance. Establish a judgment model, the above measurement includes providing multiple paired stimuli and unpaired stimuli randomly interspersed between the paired stimuli to the test subject, and real-time capture of the brain magnetic wave data of the amygdala of the brain; wherein, the paired stimuli It is followed by a related visual stimulus followed by a stimulating electrical signal. The above-mentioned related visual stimulus will remind the subject of the subsequent stimulating electrical signal, and the above-mentioned unpaired stimulus is accompanied by a non-irritating blank after a related visual stimulus. Signal; here, the brain magnetic wave data acquired by the amygdala of the subject’s brain in response to the aforementioned paired stimulus is defined as paired brain magnetic wave data, and the brain magnetic wave data acquired in response to the aforementioned unpaired stimulus is defined as Unpaired electroencephalogram data, and then calculate the above-mentioned unpaired electroencephalogram data to obtain the characteristic value of the mental stress of the subject; the measurement method includes the following steps: a). Provide a plurality of paired stimuli in sequence and a plurality of random interspersed in the above The above-mentioned unpaired stimulus between paired stimuli is given to a subject, and the plurality of unpaired brain wave data of the above-mentioned subject are acquired in the above order in real time; b). The first half of the above-mentioned multiple acquisitions are distinguished according to the above order The complex unpaired brain wave data captured several times are early response data, and the complex unpaired brain wave data captured several times in the second half are late response data; c). Calculate the above unpaired brain in the early response data Magnetic wave data to obtain an early unpaired electroencephalogram data, and calculating the aforementioned unpaired electroencephalogram data in the aforementioned late response data to obtain a late unpaired electroencephalogram data; d). Calculate the aforementioned early unpaired electroencephalogram data and the aforementioned late unpaired electroencephalogram data to obtain a characteristic value of cerebral mental stress; and e). Compare the characteristic value of cerebral mental stress with the above judgment model to generate a ratio Match the result and output the above-mentioned comparison result. As for the measurement method described in item 1 of the scope of patent application, the above step a) also includes a non-related visual stimulus randomly inserted multiple times. The measurement method described in item 1 of the scope of patent application, wherein step c) is to calculate the mathematical average of the unpaired brain wave data in the early response data, and calculate the unpaired brain wave in the late response data. The mathematical average of the magnetic wave data. As for the measurement method described in item 1 of the scope of patent application, the calculation of step d) is to subtract the aforementioned unpaired electroencephalogram data from the aforementioned early unpaired electroencephalogram data. The measurement method described in item 1 of the scope of patent application, wherein step e) compares the above-mentioned brain stress characteristic value with the above judgment model, and when the above-mentioned brain stress characteristic value is less than that of the above judgment model, the comparison result is the above The test subject has too much mental stress and outputs the above comparison results. The measurement method described in item 1 of the scope of the patent application further includes the step f) of checking the number of the above-mentioned related visual stimuli reported by the test subject after the above-mentioned step a). The measurement method described in item 1 of the scope of the patent application further includes the step of continuously acquiring brain magnetic wave data of the subject without the relevant visual stimulation for a period of time before the above step a) to establish a measurement benchmark g). A measuring device for detecting the characteristic value of mental stress in the brain, which stores at least one judgment model The above-mentioned measuring device is used to detect the mental stress of a test subject in a magnetically shielded space. The measuring method is to measure the characteristic values of the mental stress of a certain number of healthy subjects in advance to establish a judgment model. The measurement includes Provide multiple paired stimuli and unpaired stimuli randomly interspersed between the above-mentioned paired stimuli to the test subject, and instantly capture the brain magnetic wave data of the amygdala of the brain; wherein the above-mentioned paired stimulus is accompanied by a related visual stimulus A stimulating electrical signal, the above-mentioned related visual stimulus will make the subject think of the subsequent stimulating electrical signal, and the above-mentioned unpaired stimulus is accompanied by a non-irritating blank signal after a related visual stimulus; here, the subject will be tested The electroencephalogram data acquired by the amygdala in response to the aforementioned paired stimulus is defined as paired electroencephalogram data, and the electroencephalogram data acquired in response to the aforementioned unpaired stimulus is defined as unpaired electroencephalogram data, and then calculate The above-mentioned unpaired electroencephalogram data is used to obtain the characteristic value of the mental stress of the subject’s brain. The measuring device includes: a server including a processing element and a storage element for storing the above-mentioned judgment model; one being actuated by the above-mentioned server and provided The visually stimulated display; an electrical stimulator that is actuated by the server to provide the stimulating electrical signal; and a brain magnetic wave measuring device, which is set on the head of the subject for capturing the brain of the subject The amygdala of the part responds to the unpaired electroencephalogram data of the unpaired stimulus, and outputs the unpaired electroencephalogram data to the server, and the processing element distinguishes the complex unpaired electroencephalogram data acquired in the first half of the plurality of acquisitions as The early response data and the above-mentioned complex unpaired brain wave data captured in the second half of the number of times are the late response data, and then the mathematical average of the above early response data is calculated to obtain an early unpaired brain wave data, and the calculation of the above-mentioned late response data Mathematical average to obtain a later stage unpaired brainwave data, and use the above-mentioned early unpaired brainwave number According to subtracting the above-mentioned late-stage unpaired brain wave data, a characteristic value of brain mental stress is obtained. The measuring device described in item 8 of the scope of patent application, wherein the magnetic brain wave measuring device is a helmet with a complex optical pumping magnetic field meter. The measurement system described in item 8 of the scope of patent application, wherein the electroencephalogram measurement device is a helmet with a plurality of superconducting quantum interference elements.

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