TWI685280B - Air plasma surface treatment apparatus for surface modification of tube inner wall by grafting - Google Patents

Abstract

An air plasma surface treatment apparatus for surface modification of tube inner wall by grafting, adapted to treat a tube, is provided. The air plasma surface treatment apparatus includes a pulse generator, a first gas source, a second gas source, a monomer source, a nozzle, a first gas path, a second gas path, and a conductive plate. The pulse generator is utilized for generating a high-voltage pulse. The first gas path is connected from the first gas source to the nozzle. The high-voltage pulse is applied to the first gas path for generating air plasma in the tube. The second gas path is connected from the second gas source through the monomer source to the nozzle for providing monomers to the tube. The conductive plate is aligned to the nozzle. The tube is disposed between the nozzle and the conductive plate.

Description

Atmospheric plasma surface treatment equipment for graft modification of inner wall of pipe

The invention relates to plasma surface treatment equipment, in particular to atmospheric plasma surface treatment equipment used for graft modification of inner wall of pipes.

In recent years, the progress of synthetic materials in the application of biomedicine is very rapid. Many artificial materials are almost comparable to natural tissues in physical properties. However, because the surface characteristics of the material are incompatible with the biochemical structure of the human body, it will face some difficult problems in practical application, such as thrombosis, inflammation and infection. Therefore, many surface treatment technologies have been developed to enhance the biocompatibility of materials.

Among these surface treatment technologies, plasma surface treatment technology can act on the surface of the material within a depth of 10 microns, without compromising the characteristics of the material body. In addition, plasma surface treatment can also obtain diverse material surface characteristics by changing its air intake type, processing power, processing time and other parameters to meet actual needs. Therefore, the technology of plasma surface treatment has been widely used in the surface modification of biomedical materials.

However, due to the distance and range of the generated plasma, the traditional plasma surface treatment technology cannot effectively perform surface treatment on the inner wall of the pipe (such as artificial blood vessels, catheters, etc.).

In view of this, the present invention provides an atmospheric plasma surface treatment device for graft modification of the inner wall of a pipe, which can perform surface treatment on the inner wall of the pipe.

An embodiment of the present invention provides an atmospheric plasma surface treatment device for graft modification of an inner wall of a pipe, which is used for surface treatment of an inner wall of a pipe. The atmospheric plasma surface treatment equipment includes a pulse generator, a first gas source, a second gas source, a monomer source, a nozzle, a first gas flow path, and a second gas flow Road and a conductive board. The pulse generator includes a positive electrode and a negative electrode to generate a high-voltage pulse. The first gas source is used to provide a first gas. The second gas source is used to provide a second gas as a carrier gas. The polymer monomer source is used to provide a polymer monomer. The carrier gas is used to carry high molecular monomers. The nozzle is used to connect the pipe. The first gas flow path is connected to the nozzle by the first gas source, and the high-pressure pulse generated by the pulse generator is applied to the first gas flow path to generate atmospheric plasma to be emitted from the nozzle. The second gas flow path is connected to the nozzle by the second gas source through the polymer monomer source to provide the polymer monomer to the inside of the pipe. The conductive plate is aligned with one of the nozzles. The pipe is arranged between the nozzle and the conductive plate.

Compared with the traditional plasma surface treatment technology, the present invention The provided atmospheric plasma surface treatment equipment can generate a long distance plasma in the atmospheric environment to facilitate the cleaning, cross-linking, functionalization and polymerization of the inner wall of the pipe Wait for surface treatment.

The specific embodiments adopted by the present invention will be further described by the following embodiments and drawings.

10,20‧‧‧tube

100,200‧‧‧Atmospheric plasma surface treatment equipment

120,220‧‧‧Pulse generator

130,230‧‧‧First gas source

140‧‧‧Second gas source

150‧‧‧polymer monomer source

160,260‧‧‧ nozzle

170,270‧‧‧ First gas flow path

180‧‧‧ Second gas flow path

172,182,272‧‧‧Flow controller

190,290‧‧‧ conductive plate

122,222‧‧‧Positive

124,224‧‧‧Negative

D1‧‧‧Preset distance

The first figure is the configuration diagram of the first embodiment of the atmospheric plasma surface treatment equipment for graft modification of the inner wall of the present invention.

The second figure is a schematic configuration diagram of a second embodiment of the atmospheric plasma surface treatment device of the present invention.

The specific embodiments of the present invention will be described in more detail below with reference to schematic diagrams. The advantages and features of the present invention will be clearer from the following description and patent application scope. It should be noted that the drawings are in a very simplified form and all use inaccurate proportions, which are only used to conveniently and clearly assist the purpose of explaining the embodiments of the present invention.

The first figure is the configuration diagram of the first embodiment of the atmospheric plasma surface treatment equipment for graft modification of the inner wall of the present invention. The atmospheric plasma surface treatment device 100 is used to perform surface treatment on the inner wall of a pipe 10. The tubing 10 may be artificial devices such as artificial blood vessels and catheters, which are applied in the field of biomedicine. The pipe 10 may be made of polyethylene terephthalate (PET or PETE), polytetrafluoroethylene (PTFE), polyethylene (PE), silicon rubber (silicon rubber), polyvinyl chloride (PVC), polyurethane (PU) and other polymer materials. However, it is not limited to this. Any material that can be polymer grafted by plasma treatment can be applied to the present invention.

As shown in the figure, the atmospheric plasma surface treatment device 100 includes a pulse generator 120, a first gas source 130, a second gas source 140, a monomer source 150, a nozzle 160, A first gas flow path 170, a second gas flow path 180 and a conductive plate 190.

The pulse generator 120 includes a positive electrode 122 and a negative electrode 124 to generate a high voltage pulse. For an embodiment, the pulse generator may be a DC pulse generator, the positive electrode 122 is a tungsten electrode, and the negative electrode 124 is grounded. However, the present invention is not limited to this. The pulse generator 120 may also be an AC pulse generator or an RF pulse generator.

The first gas source 130 is used to provide a first gas. This first gas system is used to generate atmospheric plasma. In an embodiment, the first gas system is an inert gas such as helium (He), neon (Ne), or argon (Ar).

The second gas source 140 is used to provide a second gas. The second gas system serves as a carrier gas to carry the polymer monomer to the pipe 10. In one embodiment, the second gas is also an inert gas such as helium (He), neon (Ne), or argon (Ar). In one embodiment, the second gas is the same as the first gas. Furthermore, in an embodiment, the flow rate of the first gas is greater than the flow rate of the second gas.

The polymer monomer source 150 is used to provide a polymer monomer to the inner wall of the pipe 10 for surface treatment such as deposition and polymerization. For an embodiment, the polymer monomer has at least one functional group. The functional group is selected from the group consisting of amine group (-NH ₂ ), carboxylic acid group (-COOH), hydroxyl group (-OH), and aldehyde group (-CHO). In one embodiment, this single polymer system cyclopropylamine (Cyclopropylamine), allylamine (allylamine), cyclohexane diamine (diaminocyclohexane), n-heptyl amine (Heptylamine), ethylenediamine (ethylenediamine), n-butyl amine ( butylamine), propargylamine or propylamine. The polymer monomer source 150 can provide gaseous or liquid polymer monomers.

The first gas flow path 170 is connected to the nozzle 160 by the first gas source 130. A flow controller 172 is provided on the first gas flow path 170 to control the flow rate of the first gas. The pipe 10 is connected to the nozzle 160. The positive electrode and the negative electrode of the pulse generator 120 are in close proximity to the first gas flow path 170 to apply high-pressure pulses to the first gas flow path 170, thereby generating atmospheric plasma to be emitted from the nozzle 160 into the tube 10.

The second gas flow path 180 is connected to the nozzle 160 by the second gas source 140 through the polymer monomer source 150. A flow controller 182 is provided on the second gas flow path 180 to control the flow rate of the second gas. After the second gas provided by the second gas source 140 flows through the polymer monomer source 150, it will carry the polymer monomer to the inner wall of the tube 10 to react to form a polymer coating or change the polymer material on the inner wall of the tube Characteristics.

The conductive plate 190 is aligned with the spray direction of the nozzle 160 to increase the spray distance of the plasma. The tube 10 is disposed on the nozzle 160 and the conductive plate Between 190. In one embodiment, the conductive plate 190 is a grounded copper plate. In one embodiment, the conductive plate 190 is disposed at a predetermined distance D1 behind one end of the pipe 10 without contacting the pipe 10. For an embodiment, the predetermined distance D1 is less than 1 cm.

The following table (Table 1) lists the experimental data of the atmospheric plasma surface treatment equipment 100 of the present invention actually undergoing graft modification treatment on the inner wall of the tube to illustrate the characteristics and advantages of the atmospheric plasma surface treatment equipment 100. It is worth noting that the experimental data is only to help explain the purpose and advantages of the present invention, and does not limit the scope of the present invention.

The inner diameter of the pipe for surface treatment by the atmospheric plasma surface treatment device 100 of the present invention is 3 mm, and the length is 11.5 cm. According to the experimental data, the concentration of the grafting of cyclopropylamine used for graft modification of the inner wall of the tube was 9.514*10-7mol/cm ² .

The second figure is a schematic configuration diagram of a second embodiment of the atmospheric plasma surface treatment device of the present invention. The atmospheric plasma surface treatment device 200 is used to perform surface treatment on the inner wall of a pipe 20. The tubing 20 may be artificial devices such as artificial blood vessels and catheters, which are applied in the field of biomedicine. The pipe 20 may include polyethylene terephthalate (PET or PETE), polytetrafluoroethylene (PTFE), polyethylene (PE), silicon rubber (silicon rubber), polyvinyl chloride (PVC), polyurethane (PU) And other polymer materials.

Compared with the atmospheric plasma surface treatment apparatus 100 of the first figure, the atmospheric plasma surface treatment apparatus 200 of this embodiment does not have the second gas source 140 and the polymer monomer source 150. The pulse generator 220, the positive electrode 222, the negative electrode 224, the first gas source 230, the nozzle 260, the first gas flow path 270, and the flow controller 272 of the atmospheric plasma surface treatment apparatus 200 of this embodiment are similar to the conductive plate 290 Corresponding elements in the embodiment of the first figure will not be repeated here.

The atmospheric plasma surface treatment device 200 does not provide polymer monomers to the inner wall of the pipe 20 for deposition, polymerization and other surface treatments, but focuses on the surface cleaning and surface strengthening of the inner wall of the pipe 20 using long-distance plasma. Or it can be used with reactive gas to activate the inner wall of the pipe.

Compared with the traditional plasma surface treatment technology, the atmospheric plasma surface treatment equipment provided by the present invention can generate long-distance plasma in the atmospheric environment to facilitate the cleaning, cross-linking, and functionalization of the inner wall of the pipe. Surface treatment such as polymerization.

The above are only preferred embodiments of the present invention, and do not limit the present invention in any way. Anyone skilled in the technical field Members, within the scope of not departing from the technical means of the present invention, any equivalent replacement or modification of the technical means and technical contents disclosed in the present invention is any form of content that does not deviate from the technical means of the present invention and still belongs to the present invention Within the scope of protection.

10‧‧‧tube

100‧‧‧Atmospheric plasma surface treatment equipment

120‧‧‧Pulse generator

130‧‧‧First gas source

140‧‧‧Second gas source

150‧‧‧polymer monomer source

160‧‧‧ nozzle

170‧‧‧ First gas flow path

180‧‧‧ Second gas flow path

172,182‧‧‧Flow controller

190‧‧‧conductive plate

122‧‧‧Positive

124‧‧‧Negative

D1‧‧‧Preset distance

Claims (8)

An atmospheric plasma surface treatment device for graft modification of the inner wall of a tube is used for surface treatment of the inner wall of a tube. The atmospheric plasma surface treatment device includes: a pulse generator, including a positive electrode and a negative electrode, It is used to generate a high-pressure pulse; a first gas source is used to provide a first gas; a second gas source is used to provide a second gas as a carrier gas; and a monomer source is used To provide a polymer monomer; a nozzle; a first gas flow path, connected to the nozzle by the first gas source, and the high-pressure pulse generated by the pulse generator is applied to the first gas flow path, To generate atmospheric plasma from the nozzle; a second gas flow path, connected to the nozzle from the second gas source through the polymer monomer source, to provide the polymer monomer for graft modification; and a The conductive plate is aligned with one of the spraying directions of the nozzle, the tube is disposed between the nozzle and the conductive plate; wherein the flow rate of the first gas is greater than the flow rate of the second gas, and the tube is a polymer tube . For example, the atmospheric plasma surface treatment equipment used for graft modification of the inner wall of a tube in the first scope of the patent application, wherein the first gas system is helium (He), neon (Ne) or argon (Ar). Such as the atmospheric plasma surface treatment equipment used for graft modification of the inner wall of the tube in the first scope of the patent application, in which the second gas system is helium Gas (He), neon (Ne) or argon (Ar). For example, the atmospheric plasma surface treatment equipment for graft modification of the inner wall of the tube of the patent application item 1, wherein the polymer monomer has at least one functional group selected from the group consisting of an amine group (-NH ₂ ), carboxylic acid group (-COOH), hydroxyl group (-OH), aldehyde group (-CHO) form a group. For example, the atmospheric plasma surface treatment equipment used for graft modification of the inner wall of the tube of the patent application item 1, wherein the high voltage pulse is a DC pulse or a radio frequency pulse. For example, the atmospheric plasma surface treatment equipment used for graft modification of the inner wall of the tube in the first scope of the patent application, wherein the conductive plate is a copper plate. For example, the atmospheric plasma surface treatment equipment used for graft modification of the inner wall of the tube of the patent application item 1, wherein the conductive plate is arranged at a predetermined distance behind one end of the tube, and the predetermined distance is less than 1 cm. For example, the atmospheric plasma surface treatment equipment used for graft modification of the inner wall of the tube in the scope of patent application item 1, wherein the tube is an artificial blood vessel.

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