TWI675136B - Light-guiding and tissue-integrated biofiber components - Google Patents

Abstract

The present invention provides a biological fiber component with integrated light guide and tissue, including a plurality of biological fibers. Each biofiber is a single bare fiber or a single structural fiber. The single structural fiber has a core layer and a single or multiple cladding layers. The cladding layer is disposed around the core layer. Each biofiber system includes a light-receiving end and a light-emitting end. When light is incident from the light-receiving end, it will be emitted by the light-emitting end. In this way, the biological fiber component of the present invention can simultaneously achieve light guide and tissue integration, which is beneficial to the application of phototherapy, photogene therapy, and optogenetics.

Description

   Biological fiber component integrating light guide and tissue   

The present invention relates to a biological fiber member capable of guiding light and integrating with a tissue, and particularly to a medical member composed of biological fibers, which can be used as the following members: tube plant material, rod plant material, and plate plant material Or wire planting material.

An optical fiber is a light transmission tool that transmits light in a fiber made of glass or plastic and uses the principle of internal total reflection. With the continuous advancement of technology, optical fibers are also used in medical applications, such as endoscopes, which are flexible and flexible tubes containing multiple optical fibers. When the endoscope enters the patient's mouth, nose, digestive tract, and other internal organs, the doctor can use the endoscope to see the changes in the human internal organs, which can reduce the risk of surgery. The current endoscope is usually used when doctors need to observe the internal organs of the human body to extend the endoscope into the human body to see the image of the human body. In addition, the endoscope can also take tissue samples for biopsy. However, Existing endoscopes cannot be integrated with human tissues and cannot be placed in the body and epidermis. They need to be removed from the body after use to avoid the occurrence of inflammation and infection.

Optical fiber can also be used in phototherapy technology. Phototherapy refers to the use of sunlight or artificial light such as infrared, ultraviolet, or laser to prevent diseases and promote organism repair. At present, phototherapy can be applied to treat a variety of diseases; however, the devices used in general phototherapy are generally large-scale instruments or methods of external illumination. However, external light needs to pass through the epidermal tissue, subcutaneous tissue, and submucosa of the skin before finally reaching the tissue cells. Therefore, the phototherapy method of external light takes a long time, and it is difficult to completely irradiate the mucosal tissues and organs in the body.

Secondly, in the existing laser phototherapy technology, the endoscope is connected to the optical fiber, and the laser is precisely applied to the tumor cells by inserting into the open mouth of the human body. During the treatment, the optical fiber is inserted into the tumor, and the end inserted into the tumor uses laser fever to raise the temperature and kill the tumor cells. However, the existing treatment technology needs to remove the optical fiber after the treatment is completed, and then insert the optical fiber after the next treatment. Such repeated insertion and removal will increase the patient's discomfort and the probability of infection.

In order to improve the above-mentioned problems, the present invention provides a bio-fiber member with a light-guiding effect, which allows physicians or other professionals to clearly observe the internal organs of the human body when performing invasive surgery. In addition, the present invention also provides a biological fiber component that can be integrated with the soft and hard tissues of a living body, which can be absorbed in the living body without causing inflammation.

In view of this, the present inventor has invested a lot of research and development energy and spirit, and has continuously made breakthroughs and innovations in this field. He hopes to solve the shortcomings with novel technical means, in addition to bringing better products to society, and promoting industrial development.

The main purpose of the present invention is to provide a biofiber component that integrates light guide and tissue. It can transmit light to the target cell through the biofiber component and integrate with the cell through the biofiber to achieve any time and place. Both are available for phototherapy. In addition, the biofiber member provided by the present invention is made of bioactive glass fiber, bioinert glass fiber, or X-ray-impermeable bioactive glass fiber, or X-ray-impermeable bio-inert glass fiber, or bio-inert Made of wood, 俾 can provide the integration between the biological fiber components and the hard or soft tissues of the organism to avoid the inflammation of the biological fiber components in the organism.

In order to achieve the above object, the present invention provides a biological fiber component with integrated light guide and tissue, which may include a plurality of biological fibers. First, each of the biofibers may be composed of a single bare fiber or a single structural fiber, and the single structural fiber may be composed of a core layer and a single or multiple covering layers, and the covering layers may be covered and fused to the core. A surrounding surface of the layer. In the biofiber component with integrated light guide and tissue in the present invention, the shape of the single bare fiber, the single structural fiber, the core layer or the coating layers can be arbitrarily changed according to the needs of use, and there is no particular limitation. In a preferred embodiment of the present invention, the single bare fiber and the single structural fiber may be formed by a round long fiber, a hexagonal long fiber, or a single long fiber. In this embodiment, the core layer may be formed by a circular long fiber or a hexagonal long fiber, and the coating layers may be a circular long fiber, a hexagonal long fiber, or a strip. Long fibers are formed to strengthen the strength of the fiber woven structure.

In the biofiber member with integrated light guide and tissue in the present invention, the refractive index of the coating layer may be lower than that of the core layer; the thermal expansion coefficient of the coating layer is lower than the thermal expansion coefficient of the core layer. Wherein, the single bare fiber may be formed of bioactive glass fiber or bio-inert glass fiber, or the single bare fiber may also be X-ray-impermeable bioactive glass fiber or X-ray-impermeable Made of inert glass fibers, or bio-inert materials. Similarly, one of the single structural fibers may be made of a bio-inert material, and one of the single structural fibers may be made of a bio-active material.

In the bio-fiber member integrated with light guide and tissue in the present invention, the bio-fiber member further includes a fiber joint member. The fiber member surrounds and surrounds the bio-fibers, and can be made of a thermoplastic polymer, a thermosetting polymer, Or made of a biodegradable polymer, for example, polylactic acid (PLA), polylactic acid-glycolic acid (PolyLactide-co-Glycolide (PLGA), etc.); the fiber jointing material used in the present invention may be It can be arbitrarily changed according to the needs of use, and is not particularly limited. The fiber splicing member has an inner wall, an outer wall, and a body portion. The body portion is located between the inner wall and the outer wall. The inner wall surrounds to form a hollow channel, and the biological fibers are located in the body portion.

In the biofiber component of the light guide and tissue integration of the present invention, the biofibers are intertwined with each other, and the strong biofibers formed by the winding have high structural strength. The biofibers are a fiber braided structure. The fiber braided structure includes a central fiber shaft and a plurality of braided fiber shafts. The central fiber shaft passes straight through the fiber braided structure, and the braided fiber shafts alternately surround The central fiber axis. In addition, each of the biofibers may include a light receiving end and a light emitting end respectively. When a light beam enters through the light receiving end, it will be emitted by the light emitting end. Second, the biofiber member may have a light receiving portion and a light emitting portion. The light receiving portion may be formed by the light receiving end of the biofibers, and the light emitting portion may be formed by the light emitting end of the biofibers. Make up.

In the biofiber component integrated with light guide and tissue in the present invention, the biofibers are composed of a bioabsorbable material, a half bioabsorbable material, or a non-bioabsorbable material. When the biofibers come into contact with the soft or hard tissues of the organism, the bioactive material can be released from the biofibers to come into contact with the soft or hard tissues of the organism to integrate the soft and hard tissues. Therefore, the biofiber member of the present invention is absorbed by the organism and does not cause inflammation in the body.

In the biofiber component with integrated light guide and tissue in the present invention, the core layer may have a groove formed by an etching method, and the groove is used for cell culture, carrying chemical drugs, or carrying cultured cells to achieve disease treatment. Effect.

In the bio-fiber component integrated with light guide and tissue of the present invention, the core layer may have a hollow cylindrical channel penetrating through the core layer, and may have an entrance at the light receiving end and an exit at the light emitting end.

In the biofiber component with integrated light guide and tissue in the present invention, the covering layers may include an intermediate layer and a shell layer, the intermediate layer covering and fusing to a peripheral surface of the core layer, and the shell layer package It is covered and fused to a peripheral surface of the intermediate layer, whereby the shell layer can be covered and fused with the intermediate layer to form a multilayer single structure fiber. In the bio-fiber component integrated with light guide and tissue in the present invention, the material of the core layer, the intermediate layer, and the shell layer can be arbitrarily changed according to user needs. In one aspect of the present invention, the core layer The material of the intermediate layer and the shell layer is a bioabsorbable material; in another aspect of the present invention, the materials of the core layer, the intermediate layer and the shell layer may be non-bioabsorbable materials; in the present invention In yet another aspect, the material of the core layer, the intermediate layer, and the shell layer may be a semi-bioabsorbable material, and the present invention is not limited thereto. In addition, by selecting bioabsorbable materials with different absorption levels as the core layer, the intermediate layer, and the shell layer, the time of treatment can be further controlled.

In the biofiber member integrated with light guide and tissue in the present invention, the biofiber member may be a light guide tube plant material, and the light guide tube plant material may include the biological fibers and the fiber joint member, and the fiber joint member may be It has an inner wall, an outer wall, and a body portion. The body portion may be located between the inner wall and the outer wall. The inner wall may surround a hollow channel, and the biological fibers are located in the body portion.

In the biofiber member integrated with light guide and tissue in the present invention, the biofiber member may be a dental implant, and may include a fixing member for osseointegration with the jaw bone or skull bone, and a fixing member connected to the fixing member. A fiber splicing member connected to a dental mast supporting a dental prosthesis.

In the biofiber member integrated with light guide and tissue in the present invention, the biofiber member may be a light guide rod plant material or a light guide plant material, and the shape and structure of the light guide rod plant material and the light guide plant material The appearance and structure are the same, the difference is that the diameter of the light guide rod plant material is larger than the diameter of the light guide plant material. The light guiding rod plant material or the light guiding plant material may be disposed on a surface of a tumor cell of an organism, and the light is incident from the light receiving portion of the light guiding rod plant material or the light guiding plant material. The light emitting end of the light guide rod plant material or the light guide plant material is emitted and hits the tumor cell. In addition, the light-guiding implant can be used as a surgical suture for wound ligation, suture hemostasis, and tissue integration. The light-guiding plant material can be a bio-absorbable material, a semi-bio-absorbable material, or a bio-non-absorbable material. The bio-absorbable material can be degraded into a soluble product in the body and absorbed by the human body or an animal. Degraded, the semi-bioabsorbable material is one part that can be absorbed by the human body or animal and the other part that is not absorbed by the human body or animal.

1‧‧‧biofiber components

1a‧‧‧light pipe plant material

1b‧‧‧light guide plant material

1c‧‧‧light guiding planting material

10‧‧‧Biofiber

10’‧‧‧Single bare fiber

10 ”‧‧‧Single structure fiber

101‧‧‧ core layer

102‧‧‧ Coating

102’‧‧‧ middle layer

102 ”‧‧‧shell layer

11‧‧‧Optical receiver

12‧‧‧ light emitting end

120‧‧‧ Fiber Joint

13‧‧‧ groove

14‧‧‧ Hollow cylindrical passage

141‧‧‧Entrance

142‧‧‧Export

20‧‧‧ Fiber Joint

21‧‧‧Inner wall

22‧‧‧ outer wall

23‧‧‧Body

24‧‧‧ hollow tunnel

Fig. 1 is a schematic perspective view of a single bare fiber of the present invention; Fig. 2 is a schematic sectional view of a plurality of single bare fibers and fiber joints of the present invention; Fig. 3 is a perspective schematic view of a single structural fiber of the present invention; A cross-sectional view of a plurality of single structural fibers and fiber joints according to the invention; FIG. 5 is a schematic view of a single structural fiber according to the invention; FIG. 6A is a schematic cross-sectional view of a single structural fiber according to Embodiment 1 of the present invention; Illumination schematic diagram of a single structural fiber in Embodiment 1; FIG. 7 is a schematic perspective view of a single structural fiber in Embodiment 2 of the present invention; FIG. 8 is a schematic perspective view of a single structural fiber in Embodiment 3 of the present invention; and FIG. 9A is an implementation of the present invention A schematic cross-sectional view of the light guide tube plant material of Example 4; FIG. 9B is a schematic perspective view of the light guide tube plant material of Example 4 of the present invention; FIG. 10 is a schematic view of the light guide rod plant material of Example 5 of the present invention; 11 is a schematic perspective view of the light guiding rod planting material of Embodiment 6 of the present invention; FIG. 12 is a schematic view of the light guiding planting material of Embodiment 7 of the present invention; and FIG. 13 is a light guiding planting material of Embodiment 8 of the present invention Schematic of the wood.

The following is a description of the embodiments of the present invention through specific examples. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. In addition, the present invention can also be implemented or applied by other different specific embodiments, and various modifications and changes can be made without departing from the spirit of the present invention.

Please refer to FIGS. 1 to 2. FIG. 1 is a schematic perspective view of a single bare fiber according to the present invention; and FIG. 2 is a schematic cross-sectional view of a plurality of single bare fibers and a fiber joint according to the present invention. First, the biofiber component 1 of the light guide and tissue integration of the present invention includes a plurality of biofibers 10 and a fiber joint 20, each of which is a single bare fiber 10 '. Secondly, the fiber joint member 20 surrounds and surrounds the biofibers 10, and the fiber joint member 20 is made of a thermoplastic polymer or a thermosetting polymer or a biodegradable polymer.

Please refer to FIGS. 3 to 4. FIG. 3 is a schematic perspective view of a single structural fiber according to the present invention; and FIG. 4 is a schematic cross-sectional view of a plurality of single structural fibers and a fiber joint according to the present invention. The biological fibers 10 of the present invention are a single structural fiber 10 ". The single structural fiber 10" is composed of a core layer 101 and a covering layer 102. The covering layers 102 are covered and fused to the core. A surrounding surface of the layer 101. The coating layer 102 may be an inorganic (glass), organic resin, or plastic. The fiber joint 20 surrounds and surrounds the single structural fiber 10 ".

Please refer to FIG. 5, which is a schematic diagram of the illumination of a single structural fiber according to the present invention. The single structural fiber 10 ″ includes a light receiving end 11 and a light emitting end 12 respectively. When a light L is incident from the light receiving end 11, it will be emitted by the light emitting end 12. Secondly, the biological fiber member 1 It has a light receiving portion and a light emitting portion. The light receiving portion is composed of the light receiving end 11 of the biological fiber 10, and the light emitting portion is composed of the light emitting end 12 of the biological fibers 10. The refractive index of the cladding layer 102 may be lower than the refractive index of the core layer 101; the thermal expansion coefficient of the cladding layer 102 is lower than the thermal expansion coefficient of the core layer 101.

Example 1

Please refer to FIG. 6A and FIG. 6B. FIG. 6A is a schematic cross-sectional view of a single structure fiber according to Embodiment 1 of the present invention; FIG. 6B is a schematic diagram of a single structure fiber according to Embodiment 1 of the present invention. The biofiber 10 includes the core layer 101 and the cover layer 102, wherein the cover layer 102 includes an intermediate layer 102 'and a shell layer 102 ", and the intermediate layer 102' covers and fuses the core layer A peripheral surface of 101, the shell layer 102 "covers and fuses with a peripheral surface of the intermediate layer 102 '. As shown in FIG. 6B, when the core layer 101 cannot perform light guiding, the intermediate layer 102 ′ can perform light guiding. For example, when the biofiber member 1 is used as a dental implant, phosphorus ions and calcium can be released in the core layer 101. The ions are crystallized with the collagen in the body to form hydroxylapaite. The core layer 101, which is integrated with the bone, does not have a light-guiding effect. Therefore, the intermediate layer 102 above and below the core layer 101 can be used. 'To conduct light guidance.

Example 2

Please refer to FIG. 7, which is a schematic perspective view of a single structure fiber according to Embodiment 2 of the present invention. The biofiber 10 is composed of a bioabsorbable material. The core layer 101 has a groove 13 formed by an etching method. The groove 13 is used for cell culture, carrying chemical drugs, or carrying cells. During the treatment, the chemicals required by the patient are placed on the groove 13, and the biofiber 10 is placed in the human body or animal through the open mouth of the human or animal. When the chemical reaches the site to be treated, the chemical Chemicals are released to the treatment site for treatment. Alternatively, the cells can be cultured or carried by the grooves 13, and the cells can be placed in the human body or animal through the open mouth of the human body or animal.

Example 3

Embodiment 3 of the present invention is substantially the same as the single structural fiber described in Embodiment 2 except that the core layer 101 of Embodiment 2 has grooves, and the core layer 101 of Embodiment 3 has a hollow cylindrical channel 14. Please refer to FIG. 8, which is a schematic perspective view of a single structure fiber according to Embodiment 3 of the present invention. The single structural fiber 10 "includes a core layer 101 and a cladding layer 102. The core layer 101 has the hollow cylindrical channel 14 penetrating through the core layer 101, and has an entrance 141 at the light receiving end and a light emitting end. End of the exit 142.

Example 4

Please refer to FIG. 9A and FIG. 9B. FIG. 9A is a schematic cross-sectional view of a light pipe plant material according to Embodiment 4 of the present invention; FIG. 9B is a three-dimensional schematic view of a light pipe plant material according to Embodiment 4 of the present invention. The biofiber member 1 is a light pipe plant material 1a, and the light pipe plant material 1a includes the biofibers 10 and the fiber joint member 20, and the fiber joint member 20 has an inner wall 21, an outer wall 22, A body portion 23 is located between the inner wall 21 and the outer wall 22. The inner wall 21 surrounds a hollow channel 24. The biofibers 10 are located in the body portion 23. The light guide tube plant material 1a can be used as a blood vessel or intestine of a living body to replace a blood vessel or intestine that cannot function normally in the living body. When the blood vessel of the living body is blocked, the light guide tube planting material 1a can be used to form a branched blood vessel beside the original blood vessel, so that the blood can flow normally in the living body to avoid the problem of blood clogging in the blood vessel.

Example 5

Please refer to FIG. 10, which is a schematic diagram of a light guide rod plant material according to Embodiment 5 of the present invention. The bio-fiber component is a light-guiding rod plant material 1 b, which includes a bio-fiber 10 and a fiber joint 20. In the sub-scheme A, it can be seen that the biofiber 10 is fixed in the fiber joint 20. The pattern "*" of sub-pattern B provides additional fixation of the braided fiber axis and high tensile strength in the vertical direction, and thus produces a more robust structure than the traditional pattern "x". In sub-scheme C, it is a cross-sectional view of the light guide rod plant material 1b. The light guide rod plant material 1b includes a plurality of single structure fibers 10 "and fiber joints 20, each of which has a single structure fiber. 10 "is composed of the core layer and multiple cladding layers. The light guiding rod plant material 1b can be applied to the treatment of tumor cells. During the treatment, one end of the light guiding rod plant material 1b is placed in the tumor cells, and the laser fever is used to raise the temperature and destroy the tumor cells, and the other end is extended. To the skin surface of the human body, it can grow with the skin tissue to form a light guiding spot on the skin surface that can illuminate the light. Patients can place the controller in their pocket and be treated through the light guide at any time.

Example 6

The sixth embodiment of the present invention is substantially the same as the light guide rod plant material described in the previous embodiment 5. The difference is that the biological fiber system of embodiment 5 is a fiber braided structure, and the biological fiber system of embodiment 6 is a plurality of Made of long fibers. Please refer to FIG. 11, which is a schematic perspective view of a light guide rod plant material according to a sixth embodiment of the present invention. The light guiding rod plant material 1b includes a plurality of biofibers 10 and fiber joints 20, wherein the biofibers 10 are composed of long fibers, and the biofibers 10 can be a plurality of single bare fibers or a plurality of single fibers. Structural fibers.

Example 7

Please refer to FIG. 12, which is a schematic diagram of a light-guiding planting material according to Embodiment 7 of the present invention. The biofibers are composed of a fiber woven structure, and the biofibers can be a plurality of single bare fibers or a plurality of single structural fibers. The light-guiding material 1c can be applied to the treatment of tumor cells. In addition, the light-guiding material 1c can also be used as a surgical suture for wound ligation, suture hemostasis, and tissue integration. The light-guiding plant material 1c may be a bio-absorbable material, a half bio-absorbable material, or a bio-non-absorbable material. The bio-non-absorbable material cannot be degraded in the body. The bio-absorbable material can be degraded into a soluble product by the human body or the body. Absorbed by animals, the semi-bioabsorbable material is one part that can be absorbed by the human body or animal and the other part that is not absorbed by the human body or animal.

Example 8

Embodiment 8 of the present invention is substantially the same as the light-guiding planting material described in Embodiment 7 above. The difference is that Embodiment 7 is a fiber braided structure. However, the biological fiber system of Embodiment 8 is a plurality of long fibers. Made up. Please refer to FIG. 13, which is a schematic diagram of a light-guiding planting material according to Embodiment 8 of the present invention. The light-guiding plant material 1c includes a plurality of biofibers and fiber joints, wherein the biofibers are composed of long fibers, and the biofibers can be a plurality of single bare fibers or a plurality of single structural fibers.

However, the above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of patent protection of the present invention. Therefore, any equivalent changes made by using the description and drawings of the present invention are also included in the right of the present invention. Within the scope of protection, Chen Ming was conjoined.

Claims (9)

A light fiber and tissue-integrated biofiber component includes a plurality of biofibers, each of which is composed of a single bare fiber or a single structural fiber, and the single structural fiber is covered by a core layer and a single or a plurality of fibers It is composed of layers, and the covering layers are covered and fused to a surrounding surface of the core layer; wherein each of the biofibers includes a light receiving end and a light emitting end respectively, and when a light is received by the light After the end enters, it will be emitted from the light emitting end; wherein the biofiber member has a light receiving portion and a light emitting portion, and the light receiving portion is composed of the light receiving ends of the biofibers, and the light emits The part is composed of the light emitting ends of the biofibers; wherein the single bare fiber and the single structural fiber are composed of a bioactive glass fiber, a bioinert glass fiber, or an X-ray-impermeable organism Made of activated glass fiber or a bio-inert glass fiber with X-ray impermeability. The bio-fiber component as described in the first item of the patent application scope further includes a fiber splicing member. The fibrous component surrounds and surrounds the bio-fibers by a thermoplastic polymer, a thermosetting polymer, or a biodegradable material. Made of degradable polymer. The biofiber component according to item 1 of the application, wherein the biofibers are composed of a bioabsorbable material, a half bioabsorbable material, or a non-bioabsorbable material. The biofiber component according to item 1 of the patent application scope, wherein the core layer has a groove formed by an etching method, and the groove is used for cell culture, carrying a chemical drug, or carrying a cell. The biofiber member according to item 1 of the scope of the patent application, wherein the core layer has a hollow cylindrical channel penetrating through the core layer, and has an entrance at the light receiving end and an exit at the light emitting end. The biofiber member according to item 1 of the scope of patent application, wherein these The cladding layer includes an intermediate layer and a shell layer, the intermediate layer covers and fuses to a surrounding surface of the core layer, and the shell layer covers and fuses to a surrounding surface of the intermediate layer to form a multilayer single structure organism. Fiber; the refractive index of the cladding layers is lower than the refractive index of the core layer. The biofiber component according to item 6 of the patent application scope, wherein the coating layers are made of a biologically active or biologically inert material, and one layer of the single structural fiber is made of a biologically active material. The biofiber member according to item 1 of the scope of the patent application, wherein the biofiber member is a light pipe plant material, and the light pipe plant material includes the biological fibers and the fiber joints, and the fiber joints It has an inner wall, an outer wall, and a body portion. The body portion is located between the inner wall and the outer wall. The inner wall surrounds to form a hollow channel, and the biological fibers are located in the body portion. The biofiber member according to item 1 of the patent application scope, wherein the biofiber member is a light guide rod plant material or a light guide plant material, and is disposed on a surface of a tumor cell of an organism, and the light After the light-guiding rod plant material or the light-receiving portion of the light-guiding plant material is incident, the light-emitting end of the light-guiding rod material or the light-guiding material material is emitted to reverse the growth of the tumor cell.