TWI654971B - Cartilage repair implant, auxiliary surgical tool kit and cartilage repair system - Google Patents

Abstract

A cartilage repairing vehicle, a surgical tool set and a cartilage repairing system. The cartilage repair carrier includes a body and a plurality of positioning posts. The body is a porous structure and is used to carry a cartilage repair material. The positioning post is secured to the body and is used to insert a patient's hard bone. The surgical kit includes a positioning sleeve and a push-on instrument. The positioning sleeve has a through passage. There is a first positioning structure on the side wall of the through passage. The push-type instrument includes an outer sleeve and a push rod. The outer wall of the outer sleeve has a second positioning structure that is aligned with the first positioning structure. The outer sleeve is for passing through the through passage of the positioning sleeve. The push rod is slidably disposed within the outer sleeve. One end of the outer sleeve has a shaping knife for cutting the area to be implanted on the affected part of the patient, wherein the shape of the area to be implanted corresponds to the shape of the body.

Description

Cartilage repair carrier, surgical tool set and cartilage repair system

The present invention relates to a carrier, a kit and system, and more particularly to a cartilage repair carrier, a surgical kit and a cartilage repair system.

The articular cartilage tissue is located on the surface of the hard bone of the articular surface. It is a multifunctional and quite special tissue in human tissue. Its main function is to transmit the different direction stress of the lower surface of the articular surface, and absorb the impact of the hard bone layer to transmit the articular surface. The low friction coefficient lubricates the articular surface and cooperates with the muscle ligament tissue to produce a sliding and rolling motion pattern in different directions when the joint is active.

The self-repairing and regenerative ability of cartilage tissue is very inadequate. Once damaged, it is often unable to recover itself. According to statistics, at present, there are more than 200,000 cases of artificial joint replacement surgery in the United States due to deep-level injury of cartilage, and the case is still rising year by year. However, replacing the artificial joint requires removal of a large amount of cartilage and hard bone tissue on the joint surface of the patient, and the damage and destructiveness are quite large, and the artificial joint made of metal is only able to maintain the function for ten to fifteen years after being implanted into the body. In the case of young patients, it will face the pain of re-artificial replacement surgery, and for elderly patients, it is often impossible to undergo surgery to replace the artificial joint again. Furthermore, repeated replacement of artificial joints is likely to result in disability and poor behavior, which in turn creates a heavy burden on society and the family.

At present, the medical treatment of cartilage damage is mainly the use of cartilage transplantation to repair damaged cartilage blocks. This method is a novel medical method invented in the last year, including autologous chondrocyte transplantation (ACI) and autologous bone graft (OA, osteoarticular allograft), that is, autologous or allogeneic cartilage transplantation to regenerate new tissue. It can avoid the permanent damage of the replacement artificial joints, and it is not necessary to periodically replace the aging metal or plastic components. Among the above treatment methods, autologous cartilage transplantation is widely accepted because the graft source is the patient's own tissue, and no problem of allogeneic or xenograft immune rejection occurs.

The main surgical method for autografting is the "Mosaic plasty procedure", which was proposed by a Hungarian surgeon in 1995. The surgical method is to treat the joints of the patient without stress. Drill a piece of hard bone cylindrical plug containing cartilage and lower layer contact, and drill the same diameter of the filling groove with the same ring saw at the damaged part, and then fill the undamaged healthy autologous soft and hard bone block . However, when the cartilage wound is repaired by the mosaic compensation method, the cartilage surface between the implanted cartilage plugs has a tile interface, and the chondrocytes between the interfaces are coated in a large amount of matrix, and their splitting ability. Quite poor. Therefore, it is not easy to form regenerative fusion between the cartilage blocks; on the other hand, the fibrous cartilage tissue will be generated in the peripheral space of the cartilage block, which may cause degenerative arthritis in the wound surface in the future.

At present, the tissue culture in vitro culture of cartilage tissue to repair cartilage damage has the same problem, and after the cartilage tissue cultured in vitro is implanted into the cartilage, the problem of gap fusion between the old and new cartilage tissue is still a difficult problem that cannot be broken. Therefore, how to overcome the tissue regeneration and fusion between the transplanted cartilage (implant) and the original cartilage tissue (host) is a very important and urgent problem in orthopedic clinical research.

The invention provides a cartilage repairing carrier, a matched surgical tool set and a cartilage repairing system, which can improve the problems existing in the existing cartilage repairing surgery.

A cartilage repairing carrier according to an embodiment of the present invention includes a body and a plurality of positioning posts. The body is a porous structure and is used to carry a cartilage repair material. One end of each positioning post is fixed to the body, and the other end is used to insert a patient's hard bone.

A surgical tool set according to an embodiment of the invention includes a positioning sleeve and a push-type instrument. The positioning sleeve has a through passage. A first positioning structure is formed on the sidewall of the through passage. The push-type instrument includes an outer sleeve and a push rod. The outer sleeve of the outer sleeve has a second positioning structure. The outer sleeve is for passing through the through passage of the positioning sleeve. The second positioning structure and the first positioning structure are aligned with each other. The push rod is slidably disposed within the outer sleeve. One end of the outer cannula has a shaping knife for cutting a region to be implanted on the affected part of the patient.

A cartilage repair system according to an embodiment of the present invention includes a cartilage repair carrier, a positioning sleeve, and a push-type instrument. The cartilage repair carrier includes a body and a plurality of positioning posts. The body is a porous structure and is used to carry a cartilage repair material. One end of each positioning post is fixed to the body, and the other end is used to insert a patient's hard bone. The positioning sleeve has a through passage. A first positioning structure is formed on the sidewall of the through passage. The push-type instrument includes an outer sleeve and a push rod. The outer sleeve of the outer sleeve has a second positioning structure. The outer sleeve is for passing through the through passage of the positioning sleeve. The second positioning structure and the first positioning structure are aligned with each other. The push rod is slidably disposed within the outer sleeve. One end of the outer cannula has a shaping knife for cutting an area to be implanted on the affected part of the patient. The shape of the area to be implanted corresponds to the shape of the body.

Based on the above, in the cartilage repairing carrier, the paired surgical tool set and the cartilage repairing system of the present invention, the cartilage repairing carrier having a porous structure contributes to the gap fusion between the old and new cartilage tissues, and the surgical tool set enables the cartilage repair The carrier can be easily implanted into the affected part of the patient.

The above described features and advantages of the invention will be apparent from the following description.

A surgical tool set according to an embodiment of the invention includes a positioning sleeve and a push-type instrument. Further, a cartilage repairing system according to an embodiment of the present invention includes a cartilage repairing carrier in addition to the above-described surgical tool set.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing a cartilage repairing carrier according to an embodiment of the present invention, and Fig. 2 is a photograph of a body of a cartilage repairing carrier according to an embodiment of the present invention. Referring to FIG. 1 and FIG. 2 simultaneously, in an embodiment, the cartilage repairing carrier 100 includes a body 110 and a plurality of positioning posts 120. The body 110 is a porous structure for carrying a cartilage repair material. The positioning post 120 is a solid structure, one end of each positioning post 120 is fixed to the body 110, and the other end is used to insert a bone of the patient during the surgery to fix the entire cartilage repairing carrier 100 to the patient's hard bone. Alternatively, the body 110 of the present embodiment may further have a recess 114 and carry the material that will be used to repair the cartilage with the space of the recess 114.

In one embodiment, the body 110 of the cartilage repairing carrier 100 has a porous structure that allows adjacent tissue or cells and lubricating fluid to pass through the aperture into the interior of the body 110 or the space of the recess 114, and repair together with the cartilage repair material. The affected part enhances the healing effect.

In an embodiment, the material of the body 110 may be a biodegradable material. Therefore, after the repair of the affected part of the patient is completed, the cartilage repairing carrier 100 can be naturally decomposed and metabolized in the body, leaving only the normal cartilage that restores function, without leaving any natural products other than the human body itself in the body. In an embodiment, the material of the body 110 can use a single biodegradable material, and the material composition is relatively simple, which can further shorten the time required for complete degradation. In an embodiment, the material of the body 110 may be a single polymer material, such as polylactide (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), polyvinyl alcohol. (Polyvinyl alcohol, PVA), polyhydroxy-alkanoates (PHA), but is not limited thereto. In another embodiment, the material of the body 110 may be a composite polymer material, for example, a copolymer of at least two of the above polymers, but is not limited thereto.

In an embodiment, the material of the positioning post 120 may be a biodegradable material. In an embodiment, the material of the positioning post 120 can use a single biodegradable material, and the material composition is relatively simple, which can further shorten the time required for complete degradation. In an embodiment, the material of the positioning post 120 may be a single polymer material, such as polylactide (PLA), polyglycolic acid (PGA), polycaprolactone (PCL), polyethylene. Polyvinyl alcohol (PVA), polyhydroxy-alkanoates (PHA), but is not limited thereto. In another embodiment, the material of the positioning post 120 may be a composite polymer material, for example, a copolymer of at least two of the above polymers, but is not limited thereto. The material of the body 110 and the material of the positioning post 120 may be the same or different.

In an embodiment, the porosity of the porous structure of the body 110 is 50% to 90%, for example, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%. . In addition, the porous structure has a pore size of about 50 mm to 1,000 mm. In an embodiment, the appearance of the body 110 may be a disk shape or a shell shape, but is not limited thereto. In one embodiment, the body 110 can have a diameter of between about 8 mm and 10 mm and is suitable for use with varying degrees of defect on the cartilage. The body 110 may have a wall thickness of 1 mm to 1.5 mm, has sufficient strength to resist the compressive forces of the surrounding tissue, and does not compress to the storage space of the cartilage repair material. The total height of the body 110 can be 1.8 mm to 2.2 mm, which is substantially the same as the thickness of the human knee cartilage layer, so as not to invade the hard bone layer during operation, and does not protrude from the knee joint surface after surgery, and can be avoided. Wear by the joint surface. In an embodiment, the positioning post 120 may have a diameter of 1 mm to 2 mm, a length of 2 mm to 3 mm, and may be a solid cylinder to secure the body 110 in a manner that minimizes damage in a pair of hard bones. In the cartilage damage.

In an embodiment, the periphery of the body 110 can have a positioning angle 112. The locating angle 112 may be a protruding small cusp of about 0.5 mm to 1 mm, such as a protrusion that is triangular in appearance, but is not limited thereto. The locating angle 112 can be used with a positioning structure on other surgical instruments to assist in positioning during the surgical procedure to guide the cartilage repair carrier 100 to the correct position.

3 is a schematic view of a positioning sleeve of a surgical tool set according to an embodiment of the present invention. Referring to FIG. 3, the positioning sleeve 200 has a through passage T10. A first positioning structure 210 is formed on the side wall W10 of the through-channel T10. 4A and 4B are respectively a schematic view and a cross-sectional view showing a push type device of a surgical tool set according to an embodiment of the present invention. Referring to FIGS. 4A and 4B, the push-type instrument 300 includes an outer sleeve 310 and a push rod 320. The outer wall W20 of the outer sleeve 310 has a second positioning structure 312 thereon. The outer sleeve 310 is used to pass through the through passage T10 of the positioning sleeve 200 of FIG. The second positioning structure 312 and the first positioning structure 210 of FIG. 3 can be aligned with each other to ensure that the positioning sleeve 200 and the push-type instrument 300 can be accurately positioned during operation. The push rod 320 is slidably disposed in the outer sleeve 310 and is slidable within the outer sleeve 310 by pressing or pushing. One end of the outer sleeve 310 has a shaping knife 314 for cutting an area to be implanted (not shown) on the affected part of the patient. The shape of the implanted region may correspond to the shape of the body 110 of FIG.

Referring to FIG. 3, FIG. 4A and FIG. 4B, when the outer sleeve 310 of the push-type instrument 300 passes through the through-channel T10 of the positioning sleeve 200, the push-type instrument 300 is provided because the first positioning structure 210 is disposed in the positioning sleeve 200. The outer wall W20 of the outer sleeve 310 is provided with a second positioning structure 312, and the second positioning structure 312 must be aligned with the first positioning structure 210, so that the orientation of the pressing device 300 when sliding can be restricted. In addition, the slidable push rod 320 disposed in the outer sleeve 310 protrudes beyond the outer sleeve 310 at one end away from the shaping knife 314. When the user pushes the push rod 320 to protrude from one end of the outer sleeve 310, the push rod 320 can be pushed toward the shaping blade 314.

In one embodiment, the shape of the shaping knife 314 can be designed to match the shape of the body 110 of the cartilage repairing carrier 100, that is, the shaping knife 314 is designed to conform to the contour and configuration of the body 110 for complete containment. The body 110 allows the cartilage repair carrier 100 to be completely disposed within the area constructed by the shaping knife 314. In this way, the user only needs to push the push rod 320 to push the cartilage repairing carrier 100 into the target of the affected part. In other words, the push-type instrument 300 can be used as a tool for pushing the cartilage repairing carrier 100 to the area to be implanted, in addition to the shaping knife 314 cutting out the area to be implanted. In another embodiment, for ease of use, an elastic return member 330, such as a spring, may be disposed between the outer sleeve 310 and the push rod 320 to allow the push rod 320 to be automatically reset.

Referring to FIG. 3, in one embodiment, the positioning sleeve 200 has a plurality of cannula positioning posts 220 at one end for insertion into the affected part of the patient, so that the position of the positioning sleeve 200 can be initially fixed during the operation and initially framed. The surgical site for subsequent precise surgery. The sleeve positioning post 220 can have a length of 8-12 mm, for example 10 mm, and the outer surface of the sleeve positioning post 220 can be at an angle of 0.5-2 degrees to its central axis, for example 1 degree, to position the sleeve. The post 220 can be easily driven into the bone by reducing the resistance when it is driven into the bone for fixation. The through-channel T10 can have a diameter of 12-14 mm, for example 13 mm, providing space for subsequent surgical instrument operation. Further, the side wall W10 penetrating the passage T10 is provided with at least one discharge opening P10, for example, two or three, but is not limited thereto. In an embodiment, four discharge openings P10 may be provided. The discharge opening P10 may be an elongated opening having a width of 1-5 mm and a length of 20-30 mm, for example, an elongated opening having a width of 2.5 mm and a length of 24 mm to 25 mm. In the subsequent debridement using the debridement drill, the cleared tissue can be discharged through the discharge opening P10 to leave a clean wound.

In addition, in another embodiment, the other end of the positioning sleeve 200 opposite to the sleeve positioning post 220 may have a grip 230 for providing a user's grip to improve the convenience of use. Moreover, the first positioning structure 210 disposed on the side wall W10 of the through-channel T10 may be a guiding channel having a length of about 0.5-2 mm, for example, 1 mm, for providing the function of alignment of other surgical instruments to ensure the above. The plurality of positioning posts 120 of the cartilage repairing carrier 100 can be smoothly inserted and tightly pressed into a small hole that is pressed into the hard bone.

Referring to FIG. 1 and FIG. 4A simultaneously, in an embodiment, the shaping blade 314 is provided with a positioning angle 314A. The positioning angle 314A and the positioning angle 112 of the cartilage repair carrier 100 can cooperate to perform alignment. Therefore, when the cartilage repairing carrier 100 is placed in the area enclosed by the shaping blade 314, it is ensured that the orientation of the cartilage repairing carrier 100 is in the position to be subsequently operated.

Fig. 5 is a schematic view of a debridement drill of a surgical tool set according to an embodiment of the present invention. Referring to FIG. 3 and FIG. 5 simultaneously, in an embodiment, the debridement bit 400 can pass through the through passage T10 of the positioning sleeve 200 to remove the cartilage located in the patient's implanted area so as to be vacated in the affected part of the patient. The position of the cartilage repair carrier 100 as shown in Fig. 1 is implanted. In another embodiment, the debridement bit 400 has a stop 410. The size of the stopper 410 is larger than the size of the through passage T10. In an embodiment, the stop 410 has a diameter of about 14-16 mm, such as 15 mm. Therefore, when the debridement drill bit 400 passes through the through passage T10 of the positioning sleeve 200, the stopper portion 410 may prevent the debridement bit 400 from continuing forward, thereby limiting the debridement depth of the debridement bit 400. For example, the stop portion 410 causes the portion of the debridement bit 400 to protrude from the positioning cannula 200 to be 2 mm, and the depth of the cartilage excised by the debridement bit 400 is also 2 mm. In other words, the depth of the cartilage excised by the debridement bit 400 is the height of the body 110 of the cartilage repairing carrier 100.

In another embodiment, the diameter of the drilled portion below the debridement bit 400 is about 8 to 10 mm, which is the diameter of the body 110 of the cartilage repair carrier 100. In more detail, the diameter of the drilled portion below the debridement bit 400 is almost equal to the peripheral diameter of the body 110 of the cartilage repairing carrier 100 to clear out a space suitable for housing the cartilage repairing carrier 100. Since the debridement bit 400 will rotate within the through passage T10, there is no structure of the first positioning structure 210 corresponding to the through passage T10 on the debridement bit 400.

Fig. 6 is a schematic view of a drilling apparatus of a surgical tool set according to an embodiment of the present invention. Referring to FIG. 3 and FIG. 6 simultaneously, the drilling tool 500 of the present embodiment is configured to drill a plurality of positioning holes on the hard bone located in the patient's to-be-implanted region through the through-channel T10 of the positioning sleeve 200 (not drawn) Show). For example, the drilling apparatus 500 has a plurality of positioning posts 510, and the position of the positioning holes drilled by the positioning posts 510 may correspond to the position of the positioning posts 120 of the cartilage repair carrier 100 of FIG. For example, if the number of the positioning posts 120 is three, the azimuth angles of the three positioning posts 120 compared to the central axis of the drilling tool 500 are 0 degrees, 120 degrees, and 240 degrees, that is, the three positioning posts 120 are Segmented in a point-symmetric manner. The angle between the outer surface of the positioning post 120 and its central axis is, for example, 3 to 5 degrees to drill a positioning hole having a slope. Specifically, since the positioning hole has a slope, the deeper the positioning post 120 of the cartilage repairing carrier 100 is, the more the positioning hole can firmly grasp the positioning post 120 to firmly fix the cartilage repairing carrier 100 to the patient. The affected part.

Moreover, in another embodiment, the drilling apparatus 500 has, for example, a third positioning structure 520 that is aligned with the first positioning structure 210 of FIG. Therefore, the orientation of the drilling apparatus 500 when sliding within the outer sleeve 310 is limited, thereby ensuring that the position of the positioning hole drilled by the drilling apparatus 500 corresponds to the position of the positioning post 120 of the subsequently implanted cartilage repairing carrier 100.

7A to 7G are photographs of various stages of a cartilage repair operation of a pig using a cartilage repair system according to an embodiment of the present invention. Referring first to Figure 7A, a general pig is selected as a subject for minimally invasive surgery for the knee. The number of pigs, approximate age, weight, sex, and information on surgery and autopsy were recorded during the experiment. Before the operation, each pig only needs to fast for 24 hours. The anesthetic used in the operation is 3% sodium pentobarbital, which is injected from the hind leg at a dose of about 1 mL/kg, and the dose is increased or decreased depending on the anesthesia of each pig. After the anesthesia is confirmed, the pigs are shaved and sterilized with iodine, and the area outside the surgical site is covered with a sterile towel to expose only the joint position to ensure that the surgery is performed under aseptic conditions. Next, a wound of about 3 cm was cut in the lateral skin, and the soft tissue was peeled off to expose the position where the cartilage repairing carrier 100 as shown in Fig. 1 was to be implanted.

Next, referring to FIG. 7B, the positioning sleeve 200 shown in FIG. 3 is placed on the affected part, and then the two cannula positioning posts 220 of the positioning sleeve 200 are driven into and fixed to the affected part. Next, referring to FIG. 7C, the positioning cannula 200 is inserted using the push-type instrument 300 as shown in FIG. 4A and the area to be implanted A10 is cut out at the affected part with a shaping knife. Next, the cartilage tissue located in the area to be implanted A10 is removed by inserting the positioning cannula 200 using the debridement drill bit 400 as shown in FIG.

Next, referring to FIG. 7D, the drilling tool 500 shown in FIG. 6 is inserted into the positioning sleeve 200, and a plurality of positioning holes P20 as shown in FIG. 7E are drilled on the hard bone located in the area to be implanted A10. Next, referring to FIG. 7F, the cartilage repairing carrier 100 shown in FIG. 1 is placed in the area to be implanted A10. For ease of understanding, in FIG. 7F, the cartilage repairing carrier 100 is placed beside the area to be implanted A10, but in actual operation, the cartilage repairing carrier 100 is directly pushed into the implant to be implanted using the push-type instrument 300 as shown in FIG. 4A. District A10. Since the shape of the shaping knife is corresponding to the shape of the cartilage repairing carrier 100, and the drilling tool 500 and the positioning sleeve 200 also have a positioning structure that is aligned with each other, the position of the positioning hole P20 drilled by the drilling tool 500 will be Directly corresponding to the positioning column 120 of the cartilage repairing carrier 100, without the need for additional alignment steps, not only can shorten the time required for surgery, but also improve the chance of successful surgery due to accurate alignment. Fig. 7G shows that the cartilage repairing carrier 100 has been placed in the area to be implanted A10.

Fig. 8 is a schematic view showing the manner of use of a cartilage repairing carrier according to an embodiment of the present invention. Referring to Figure 8, the cartilage repair material is taken from the patient itself, particularly from the unstressed joint of the joint, for example, by scraping the autologous cartilage. The autologous cartilage taken out above was placed in a 10 cm culture dish, and the cartilage was chopped with a scalpel, and the size of the pieces was controlled between 560 and 800 μm in a 20-mesh to 40-mesh screen. The minced cartilage fragments were collected in a 15 ml centrifuge tube, and 5 ml of collagenase was added to the incubator at 37 ° C for 1 hour to allow some of the chondrocytes to be released. Collagenase was placed in phosphate-buffered saline (PBS) and adjusted to a ratio of 2 mg/ml PBS. The cartilage block after separation and dissolution by collagenase was placed in a centrifuge, and centrifuged at 1500 r.p.m. for 5 minutes to separate collagenase from the cartilage block. After centrifugation of the cartilage fragments, after removing the clarified collagenase supernatant (supernatant), the remaining cartilage fragments and cell tissues were washed twice with PBS and centrifuged twice to remove residual collagenase to complete the cartilage. Preparation of repair materials.

Next, the prepared cartilage repairing material was placed in a 1 c.c. syringe, and the prepared cartilage repairing material was placed on the cartilage repairing carrier 100 by injection with an 18 gauge needle (18G). Thereafter, the cartilage repairing carrier 100 is placed toward the affected part with the side carrying the cartilage repairing material so that the cartilage repairing material directly contacts the affected part. Since the cartilage repair material has a certain viscosity, it is not easily dropped from the cartilage repair carrier.

Fig. 9A and Fig. 9B are respectively an experimental example of surgery performed using the cartilage repairing system according to an embodiment of the present invention, and a photograph of the affected part after restoration using a conventional surgical tool, the surgical subjects being pigs as described above. As can be seen from Fig. 9A, 12 months after the operation using the surgical tool kit of one embodiment of the present invention, the cartilage of the affected part (as indicated by the arrow) is well restored, and no trace of the wound is observed. On the other hand, in the case of the operation of the conventional surgical tool group, the cartilage recovery condition of the affected part (as indicated by the arrow in Fig. 9B) was poor after 12 months, and the wound trace was obvious.

10A and FIG. 10B are an experimental example of an operation using a cartilage repair system according to an embodiment of the present invention, and an X-ray film of an affected part after a 6-month restoration using a conventional surgical tool, and the surgical objects are as described above. Pig. As can be seen from Fig. 10A, the cartilage of the affected part was quickly recovered and the wound depth was only 2.8 mm 6 months after the operation using the surgical tool set of one embodiment of the present invention. On the other hand, in the case of the operation of the conventional surgical tool group, the cartilage recovery of the affected part was slow after 6 months, as shown in Fig. 10B, the wound depth was 13.4 mm.

11A and FIG. 11B are photographs of an experimental example of an operation using a cartilage repair system according to an embodiment of the present invention, and a sample of an affected part after a 6-month restoration using a conventional surgical tool, the surgical objects are as described above. Pig. As can be seen from Fig. 11A, 6 months after the operation using the surgical tool set of one embodiment of the present invention, the hard bone of the affected part (as indicated by the arrow) is quickly restored, only a small amount of surgical residue, and the cartilage is well restored. On the other hand, in the case of the operation of the conventional surgical tool group, the hard bone recovery rate of the affected part (as indicated by the arrow in Fig. 11B) is slow after 6 months, and there are many surgical residues.

12A and FIG. 12B are photographs of an experimental example of an operation using a cartilage repair system according to an embodiment of the present invention, and a sample of an affected part after a 12-month restoration using a conventional surgical tool, the surgical objects are as described above. Pig. As can be seen from Fig. 12A, 12 months after the operation using the surgical tool kit of one embodiment of the present invention, the affected bone (as indicated by the arrow) has good bone recovery, almost no surgical residue, and the new hard bone tissue is indeed long. In. On the other hand, in the case of the operation of the conventional surgical tool group, the hard bone recovery condition of the affected part (as indicated by the arrow in Fig. 12B) is poor after 12 months, and there are still many surgical residues.

13A and FIG. 13B are respectively an experimental example of performing surgery using a cartilage repairing system according to an embodiment of the present invention, and a stained section of the affected part after restoration using a conventional surgical tool, the surgical subjects are pigs as described above. . 13A and 13B are stained simultaneously using Safranin-O and Fast Green FCF to further examine the condition of cartilage hyperplasia and the state of hard bone recovery.

Referring to FIG. 13A and FIG. 13B simultaneously, it can be seen from the stained area of the reddish color that the cartilage hyperplasia is good, 12 months after the operation, using the surgical tool set of one embodiment of the present invention, as indicated by the upper arrow in FIG. 13A. When the operator is operated using the conventional surgical tool set, as indicated by the upper arrow in Fig. 13B, the cartilage hyperplasia is normal. On the other hand, it can be seen from the dyed area of the solid green that, 12 months after the operation using the surgical tool set of one embodiment of the present invention, as indicated by the middle arrow in Fig. 13A, the hard bone is in a good condition, and the conventional surgery is used. The appliance group performs the operation, as indicated by the middle arrow in Fig. 13B, and the hard bone has almost no proliferation.

Fig. 14 is a quantification diagram of a wound width of an experimental example in which a cartilage repairing system according to an embodiment of the present invention is performed and a comparative example in which surgery is performed using a conventional surgical tool. Referring to FIG. 14, an experimental example in which a surgical tool set according to an embodiment of the present invention is used for surgery is only 60% of the wound width of a comparative example using a conventional surgical tool during the half year after surgery, and The width of the wound in the previous experimental example one year after surgery was about 50% of the wound width of the control one year after surgery.

In summary, in the cartilage repairing carrier, the matched surgical tool set and the cartilage repairing system of the present invention, the cartilage repairing carrier adopts a porous structure, which contributes to the gap fusion between the old and new cartilage tissues, and the surgical tool set Minimally invasive cartilage repair surgery is possible. In addition, when the cartilage repair carrier uses a biodegradable material, it can carry a substance that promotes cartilage repair, and with a set of positionable surgical instruments, the cartilage repair carrier can be accurately positioned and implanted into the affected part of the patient in a minimally invasive manner. In this way, the cartilage defect site can be assisted in the case of less damage to the hard bone, and the cartilage repair carrier can be naturally decomposed and metabolized in the body after the repair is completed.

Although the present invention has been disclosed in the above embodiments, it is not intended to limit the present invention, and any one of ordinary skill in the art can make some changes and refinements without departing from the spirit and scope of the present invention. The scope of the invention is defined by the scope of the appended claims.

100‧‧‧Cartilage repair carrier

110‧‧‧ body

112‧‧‧Positioning angle

114‧‧‧ Groove

120, 510‧‧‧ positioning column

200‧‧‧ positioning casing

210‧‧‧First positioning structure

220‧‧‧ casing positioning column

230‧‧‧ grip

T10‧‧‧through passage

W10‧‧‧ side wall

P10‧‧‧ discharge opening

300‧‧‧Pushing instruments

310‧‧‧Outer casing

312‧‧‧Second positioning structure

314‧‧‧Shaping knife

314A‧‧‧ positioning angle

320‧‧‧Put

330‧‧‧Elastic recovery parts

W20‧‧‧ outer wall

400‧‧‧Developing drill bits

410‧‧‧stop

500‧‧‧Drilling equipment

520‧‧‧ Third positioning structure

A10‧‧‧ to be implanted

P20‧‧‧Positioning hole

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view of a cartilage repairing carrier according to an embodiment of the present invention. 2 is a photograph of a solid of a cartilage repairing carrier according to an embodiment of the present invention. 3 is a schematic view of a positioning sleeve of a surgical tool set according to an embodiment of the present invention. 4A and 4B are respectively a schematic view and a cross-sectional view showing a push type device of a surgical tool set according to an embodiment of the present invention. Fig. 5 is a schematic view of a debridement drill of a surgical tool set according to an embodiment of the present invention. Fig. 6 is a schematic view of a drilling apparatus of a surgical tool set according to an embodiment of the present invention. 7A to 7G are photographs of various stages of a cartilage repair operation using a cartilage repair system according to an embodiment of the present invention. Fig. 8 is a schematic view showing the manner of use of a cartilage repairing carrier according to an embodiment of the present invention. 9A and 9B are photographs of an affected part of a case in which a cartilage repairing system according to an embodiment of the present invention is used for surgery, and a comparative example in which a conventional surgical tool is used for surgery, after 6 months of recovery. 10A and FIG. 10B are an experimental example of surgery performed using the cartilage repair system according to an embodiment of the present invention, and an X-ray film of an affected part after restoration for 6 months in a comparative example of surgery using a conventional surgical tool. Fig. 11A and Fig. 11B are photographs of an experimental example of an operation of a cartilage repair system according to an embodiment of the present invention, and a control sample of a control using a conventional surgical tool, which was restored after 6 months, respectively. Fig. 12A and Fig. 12B are photographs of an experimental example of an operation of a cartilage repair system according to an embodiment of the present invention, and a control sample of a control using a conventional surgical tool, which was restored after 12 months, respectively. Fig. 13A and Fig. 13B are staining sections of an affected part of an experimental example in which a cartilage repairing system according to an embodiment of the present invention is used and a control which is performed using a conventional surgical tool, after 12 months of recovery, respectively. Fig. 14 is a quantification diagram of a wound width of an experimental example in which a cartilage repairing system according to an embodiment of the present invention is performed and a comparative example in which surgery is performed using a conventional surgical tool.

Claims (26)

A cartilage repairing carrier comprises: a body, a porous structure for carrying a cartilage repairing material, wherein the porous structure has a porosity of 50% to 90%; and a plurality of positioning columns, each of which is fixed at one end of the positioning column To the body, the other end is used to insert a patient's hard bone. The cartilage repairing carrier according to claim 1, wherein the material of the body is a biodegradable material. The cartilage repairing carrier according to claim 1, wherein the material of the body is polylactic acid, polyglycolic acid, polycaprolactone, polyvinyl alcohol, polyhydroxyalkanoic acid or a copolymer of at least two of the above polymers. . The cartilage repairing carrier of claim 1, wherein the periphery of the body has a positioning angle. A surgical tool set comprising: a positioning sleeve having a through passage, wherein a side wall of the through passage has a first positioning structure; and a pressing device comprising an outer sleeve and a push rod, wherein the outer sleeve The outer wall has a second positioning structure, the outer sleeve is configured to pass through the through passage of the positioning sleeve, and the second positioning structure is aligned with the first positioning structure, and the push rod is slidably disposed on the Inside the outer cannula, one end of the outer cannula has a shaping knife for cutting a region to be implanted on the affected part of the patient. The surgical tool set of claim 5, wherein the positioning sleeve has a plurality of cannula positioning posts at one end for insertion into the affected part of the patient. The surgical tool set of claim 6, wherein the other end of the positioning sleeve has a grip for the user to hold. The surgical tool set of claim 5, wherein the side wall of the through passage is further provided with a discharge opening. The surgical tool set of claim 5, wherein the shaping tool has a positioning angle. The surgical tool set of claim 5, further comprising a debridement drill bit for removing the cartilage located in the patient to be implanted region through the through passage of the positioning sleeve. The surgical tool set of claim 10, wherein the debridement bit has a stop portion having a size larger than a size of the through passage for limiting a debridement depth of the debridement bit. The surgical tool set of claim 5, further comprising a drilling device for drilling through the through passage of the positioning sleeve to drill a plurality of hard bones in the patient to be implanted area Positioning holes. The surgical tool set of claim 12, wherein the drilling tool has a third positioning structure, and the third positioning structure and the first positioning structure are aligned with each other. A cartilage repairing system comprising: a cartilage repairing carrier comprising a body and a plurality of positioning posts, wherein the body is a porous structure for carrying the cartilage repairing material, one end of each of the positioning posts is fixed to the body and the other end of each of the positioning posts is for inserting a patient's hard bone; a positioning sleeve has a through passage, wherein the through hole The first side of the channel has a first positioning structure; and a pressing device includes an outer sleeve and a push rod, wherein the outer sleeve has a second positioning structure on the outer wall, and the outer sleeve is used to pass through the positioning sleeve The through-channel, and the second positioning structure and the first positioning structure are aligned with each other, the push rod is slidably disposed in the outer sleeve, and one end of the outer sleeve has a shaping knife for the patient An area to be implanted is cut out from the affected part, and the shape of the area to be implanted corresponds to the shape of the body. The cartilage repair system of claim 14, wherein the material of the body is a biodegradable material. The cartilage repairing system according to claim 14, wherein the material of the body is polylactic acid, polyglycolic acid, polycaprolactone, polyvinyl alcohol, polyhydroxyalkanoic acid or a copolymer of at least two of the above polymers. . The cartilage repair system of claim 14, wherein the porous structure has a porosity of 50% to 90%. The cartilage repair system of claim 14, wherein the periphery of the body has a positioning angle. The cartilage repair system of claim 14, wherein the positioning sleeve has a plurality of cannula positioning posts at one end for insertion into the affected part of the patient. The cartilage repairing system of claim 19, wherein the other end of the positioning sleeve has a grip for the user to hold. The cartilage repairing system of claim 14, wherein the side wall of the through passage is further provided with a discharge opening. The cartilage repair system of claim 14, wherein the shaping tool has a positioning angle. The cartilage repair system of claim 14, further comprising a debridement drill bit for removing the cartilage located in the patient to be implanted region through the through passage of the positioning sleeve. The cartilage repairing system of claim 23, wherein the debridement bit has a stop portion having a size greater than a size of the through passage for limiting a debridement depth of the debridement bit. The cartilage repair system of claim 14, further comprising a drilling device for drilling through the through passage of the positioning sleeve to drill a plurality of hard bones in the patient to be implanted region Positioning holes corresponding to the positioning posts. The cartilage repairing system of claim 25, wherein the drilling tool has a third positioning structure, the third positioning structure and the first positioning structure being aligned with each other.