TWI638006B - 疤 疤 patch and its manufacturing method - Google Patents

Abstract

The invention discloses a mites removal patch and a manufacturing method thereof.疤 疤 patch contains polyurethane layer And a polyurethane film formed thereon, and a plurality of dot glues are coated on the top of the polyurethane film. Among them, a mixture of 2.0 to 2.2 moles of hardener hexamethylene diisocyanate, 0.6 to 0.8 moles of polyethylene glycol, 0.7 to 0.9 moles of polypropylene glycol and 0.4 to 0.6 moles of 1,4-butane Alcohol to form a main agent; 0.05 to 0.35 mol of a functional additive is added to the addition of 1,4-butanediol to prepare a prepolymer; and the prepolymer is further reacted to form a polyurethane adhesive layer.

Description

疤 疤 patch and its manufacturing method

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sputum-removing patch technology, and more particularly to a patch for preventing scarring after surgery which is produced by using a moisturizing and gas permeable polyurethane gel and having excellent moisturizing and water absorbing effects, and a method for producing the same.

It is known that in the techniques of the conventional mites and the manufacturing method thereof, there are (1) silicone technology, (2) sodium alginate technology using acrylic as a carrier, and no functional additive is added to the conventional mites. As far as the functional additive is added, it is traditionally a physical mixing method. The traditional silicone coating has a non-breathable patch, is expensive, exhibits a wetting phenomenon, has a poor moisturizing effect, and has no antibacterial function, so it is to be improved. In addition, the traditional sodium alginate technology using acrylic as a carrier is synthesized by acrylic polymerization, and the remaining monomer is toxic and has an allergic reaction to the skin. The conventional mites are not coated on the polyurethane film. Apply a bit of glue.

In view of this, the main object of the present invention is to improve the cost of the traditional silicone rubber, the gas permeability is not good, and the moisturizing effect is poor. When the traditional sodium alginate is used as a carrier, it has the problem of toxic monomer residue and no antibacterial function.

In order to achieve the above object and solve the problems, the main object of the present invention is to provide a mites patch comprising: a polyurethane adhesive layer, a bottom for attaching to a wound of the skin; and a polyurethane film, Formed on the polyurethane adhesive layer, and the top of the polyurethane film is coated with a plurality of punctiform rubber; wherein, 2.0 to 2.2 mol of hardener hexamethylene diisocyanate, 0.6 to 0.8 mol of polyethylene glycol, 0.7~0.9 mole of polypropylene glycol and 0.4~0.6 mole of 1,4-butanediol to form a main agent, wherein 0.05~ is added when adding 1,4-butanediol 0.35 moles of functional additive to make a prepolymer; the prepolymer is then reacted to form a polyurethane layer.

Preferably, the primary agent contains 0.1 mole of the functional additive relative to 1.0 mole of prepolymer.

Preferably, the functional additive is selected from the group consisting of hyaluronic acid, collagen, chitin, sodium alginate and zinc ions.

Preferably, the thickness of the polyurethane adhesive layer is between 0.5 and 1.0 mm, and the water vapor permeability of the polyurethane adhesive layer is 1,500 g/m 2 per day.

Preferably, the thickness of the polyurethane film is between 0.01 and 0.04 mm, and the water vapor transmission rate of the polyurethane film is greater than 3000 g/m 2 per day.

Preferably, the dot glue is a pressure sensitive adhesive or a hot melt adhesive.

Another object of the present invention is to provide a method for manufacturing a mites patch comprising: mixing 2.0 to 2.2 moles of hardener hexamethylene diisocyanate, 0.6 to 0.8 moles of polyethylene glycol, and 0.7 to 0.9 moles. % polypropylene glycol and 0.4-0.6 moles of 1,4-butanediol to form a main agent, wherein 0.05 to 0.35 moles of functional additive is added to the addition of 1,4-butanediol to prepare Prepolymer; reacting the prepolymer into a polyurethane adhesive layer; forming a polyurethane film on the polyurethane adhesive layer, and the bottom of the polyurethane adhesive layer is used for attaching to the wound of the skin; and applying a plurality of dot glue on the polyurethane film .

Preferably, the primary agent contains 0.1 mole of the functional additive relative to 1.0 mole of the prepolymer.

Preferably, the functional additive is selected from the group consisting of hyaluronic acid, collagen, chitin, sodium alginate and zinc ions.

Preferably, the thickness of the polyurethane layer is between 0.5 and 1.0 mm, and the water vapor transmission rate is 1500 g/m 2 per day.

10‧‧‧Polyurethane layer

20‧‧‧ Polyurethane film

21‧‧‧ Point glue

30‧‧‧ wounds

31‧‧‧ skin

Fig. 1A is a schematic cross-sectional view of a mites patch of the present invention; and Part B is a top view of the mites patch of the present invention.

Referring to FIG. 1A to B, a schematic diagram of a post-operative sputum patch provided in a first embodiment of the present invention is disclosed, and a post-operative sputum patch has a flexible polyurethane gel layer 10, A polyurethane film 20 is formed on the polyurethane rubber layer 10, and the polyurethane rubber layer 10 is attached to the wound 30 of the skin 31. A plurality of dot glues 21 are applied around the polyurethane film 20.

In the present invention, a polyurethane film 20 is formed on the polyurethane rubber layer 10, and the bottom of the polyurethane rubber layer 10 is a wound 30 to which the skin 31 is attached; wherein the polyurethane rubber layer 10 is firstly composed of 2.0 to 2.2 mol hardeners. Hexamethylene diisocyanate (HDI) with 0.6~0.8 mole polyethylene glycol (PEG, Mn2000) and 0.7~0.9 mole polypropylene glycol (PPG, Mn2000) and 0.4~0.6 The 1,4-butanediol forms a main agent, and then adds 0.05 to 0.35 mol of a functional additive to the 1,4-butanediol to prepare a prepolymer; The prepolymer is reacted to form a polyurethane adhesive layer 10; further, the polyurethane film 20 is coated with a plurality of dot adhesives 21.

In order to make the flexible polyurethane adhesive layer 10 moisturizing and retaining moisture, a functional additive is optionally added to the polyurethane adhesive layer 10, and the functional additive is selected from the group consisting of hyaluronic acid collagen (collagen) and chitin (chitin/chitosan). ), sodium alginate and zinc ions. Hyaluronic acid and collagen have a moisturizing function for wounds, and polyethylene glycol and polypropylene glycol have a function of absorbing water for wounds, and chitin has a bacteriostatic function for wounds. Both the urethane layer 10 and the urethane film 20 are breathable and waterproof.

According to the present invention, hexamethylene diisocyanate is reacted with PEG and PPG and hyaluronic acid in the collagen-OH group, and hexamethylene diisocyanate is chemically crosslinked with chitin-NH2. These chemically crosslinked polyurethane rubber layers 10 are attached to the polyurethane film, which is quite different from the physical addition of the conventional additives.

According to the present invention, the thickness of the polyurethane rubber layer 10 is between 0.5 and 1.0 mm, preferably 0.75 mm, and the water vapor permeability of the polyurethane rubber layer 10 is 1500 g/m ² . Day. According to the present invention, the polyurethane adhesive layer 10 is very soft, and its Shore A is between 30 and 50, and its elongation is between 200 and 800%. The tensile strength is 10 MPa.

According to the present invention, the thickness of the polyurethane film 20 is between 0.01 and 0.04 mm, preferably 0.025 mm, and the moisture permeability of the polyurethane film is MVTR greater than 3000 g/m ² . Day. The function of the polyurethane film 20 is to block external bacterial infection, waterproof, antibacterial and as a carrier.

The difference between the present invention and the conventional technology is that: (1) The present invention additionally adds a functional additive selected from the group consisting of hyaluronic acid, collagen, sodium alginate and chitin, and the conventional technology does not add a functional additive. (2) In terms of the manner of addition, it is conventionally a physical mixing mode, and the method of adding the post-operative sputum patch of the present invention is by chemical crosslinking. The post-operative sputum patch of the present invention has the advantages of very good moisturizing and water absorbing effect and softness, and the water absorbing effect is PEG derived from the main agent. And PEG2000 and PPG2000 in the mixture. Hyaluronic acid and collagen have a moisturizing function on the wound, and chitin has a bacteriostatic function on the wound, and is designed according to the intended purpose of designing the post-operative sputum patch, hyaluronic acid), collagen, sodium alginate and chitin. You can choose one or you can choose either or whatever. (3) The conventional carrier is a non-woven fabric, and the present invention uses a dot-coated glue 21 because the dot-like glue 21 has gas impermeability, and the dot-like glue 21 is distributed in a dot shape on the polyurethane film 20 to maintain the polyurethane film 20. It is breathable. (4) The post-operative sputum patch of the present invention does not have residual toxic monomers remaining after the conventional acryl polymerization.

Example A

Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mol hardener hexamethylene diisocyanate and 0.8 Moth polyethylene glycol PEG2000 (polyethylene glycol, PEG, Mn2000) and 0.7 mole polypropylene glycol PPG2000 (PPG2000) and 0.5 mole of 1,4-butanediol form the main agent, after adding 1,4 - Butanediol is not added with functional additive collagen to form a prepolymer; it is then reacted to form a polyurethane adhesive layer; and a plurality of dot glues are applied to the polyurethane film.

Instance B

Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mol hardener hexamethylene diisocyanate and 0.7 Molybdenum polyethylene glycol PEG2000 and 0.8 mole polypropylene glycol PPG2000 form a main agent with 0.4~0.6 moles of 1,4-butanediol, and no functional additive collagen is added when adding 1,4-butanediol. Forming a prepolymer; reacting to form a polyurethane adhesive layer; and applying a plurality of dot glues on the polyurethane film.

Example C

Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the skin wound; wherein the polyurethane adhesive layer is firstly composed of 2.2 mol hardener hexamethylene diisocyanate and 0.6 Molybdenum polyethylene glycol PEG2000 and 0.9 mole polypropylene glycol PPG2000 form a main agent with 0.4~0.6 moles of 1,4-butanediol, and no functional additive collagen is added when adding 1,4-butanediol. Forming a prepolymer; reacting to form a polyurethane adhesive layer; and applying a plurality of dot glues on the polyurethane film.

Example D

Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mol hardener hexamethylene diisocyanate and 0.8 Molybdenum PEG2000 and 0.7 mole polypropylene glycol PPG2000 form a main agent with 0.4~0.6 moles of 1,4-butanediol, and then add 0.1 mole of functional additive collagen when adding 1,4-butanediol. The protein is made into a prepolymer; the reaction is made into a polyurethane adhesive layer; and a plurality of dot glues are coated on the polyurethane film.

Example E

Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mol hardener hexamethylene diisocyanate and 0.8 Moer polyethylene glycol PEG2000 and 0.7 mole polypropylene glycol PPG2000) form a main agent with 0.4~0.6 moles of 1,4-butanediol, and then add 0.2 mole energy additive when adding 1,4-butanediol. Collagen to form a prepolymer; reacted to form a polyurethane adhesive layer; and apply a plurality of dot glues to the polyurethane film.

Example F

Forming a polyurethane adhesive layer, wherein a polyurethane film is formed on the polyurethane adhesive layer, and the bottom of the polyurethane adhesive layer is attached to the wound of the skin; wherein the polyurethane adhesive layer is firstly composed of 2.2 mol hardener hexamethylene diisocyanate and 0.8 Molybdenum PEG2000 and 0.7 mole polypropylene glycol PPG2000 form a main agent with 0.4~0.6 moles of 1,4-butanediol, and then add 0.3 mole of functional additive collagen when adding 1,4-butanediol. The protein is made into a prepolymer; the reaction is made into a polyurethane adhesive layer; and a plurality of dot glues are coated on the polyurethane film.

Properties of polyurethane adhesive layer

The above embodiments are merely illustrative of preferred embodiments of the invention, but are not to be construed as limiting the scope of the invention. It should be noted that various modifications and improvements can be made by those skilled in the art without departing from the spirit and scope of the invention.

Claims (8)

A mites patch comprising: a polyurethane adhesive layer having a bottom for attaching to a wound of a skin; and a polyurethane film formed on the polyurethane adhesive layer, and the polyurethane film is coated with a plurality of dots above a rubber; a mixture of 2.0 to 2.2 moles of a hardener hexamethylene diisocyanate, 0.6 to 0.8 moles of polyethylene glycol, 0.7 to 0.9 moles of polypropylene glycol and 0.4 to 0.6 moles of 1,4 - butanediol to form a main agent; adding 0.05 to 0.35 moles of a functional additive to the addition of 1,4-butanediol to form a prepolymer; a polyurethane adhesive layer, wherein the functional additive is selected from the group consisting of hyaluronic acid, collagen, chitin, sodium alginate and zinc ions. The anti-caries patch according to claim 1, wherein the molar ratio of the main agent to the functional additive is 4.1 to 4.3: 0.1 to 0.3. The anti-mite patch according to claim 1, wherein the polyurethane adhesive layer has a thickness of 0.5 to 1.0 mm, and the water vapor permeability is 1500 to 2000 g/m 2 per day. The anti-mite patch according to claim 1, wherein the polyurethane film has a thickness of 0.01 to 0.04 mm and a water vapor permeability of more than 3000 g/m 2 per day. The anti-mite patch according to claim 1, wherein: the punctiform glue is a feeling Glue or hot melt adhesive. A method for manufacturing a mites patch comprising: mixing 2.0 to 2.2 moles of a hardener hexamethylene diisocyanate, 0.6 to 0.8 mole % of polyethylene glycol, 0.7 to 0.9 mole % of polypropylene glycol and 0.4~0.6 mol of 1,4-butanediol to form a main agent, wherein 0.05-0.35 mol of a functional additive is added to the addition of 1,4-butanediol to prepare a prepolymer The prepolymer is reacted to form the polyurethane adhesive layer; a polyurethane film is formed on the polyurethane adhesive layer, and the bottom of the polyurethane adhesive layer is used for attaching to a wound of a skin; and coating on the polyurethane film The plurality of punctiform gels, wherein the functional additive is selected from the group consisting of hyaluronic acid, collagen, chitin, sodium alginate and zinc ions. The method for manufacturing a mites patch according to claim 6, wherein the molar ratio of the main agent to the functional additive is 4.1 to 4.3: 0.1 to 0.3. The method for manufacturing a mites patch according to claim 6, wherein: the thickness of the urethane layer is between 0.5 and 1.0 mm, and the water vapor transmission rate is 1,500 to 2,000 g/m 2 per day. ruler.