TWI624288B - System for dermatological layered treatment - Google Patents

Abstract

The present invention provides a layered skin treatment system comprising a subcision device and an electromagnetic radiation device. The subcision device is used to cut a fiber bundle having a skin depth greater than 1 mm on a target area. The electromagnetic radiation device is used to generate an electromagnetic radiation to illuminate skin cells having a skin depth of less than 1 mm on the target area. With this system, both shallow skin smoothing and deep tissue hyperplasia and filling can be achieved.

Description

A layered system for treating skin

The present invention relates to a system for treating skin; in particular to a system for stratifying skin.

Almost everyone has one or more skin moles. These skin conditions include, for example, wrinkles, poor skin texture (eg, rough skin), enlarged pores, rosacea, blush/redness, dermatoglyphics (eg, stretch marks), scars, acne, excessive sebum ( The secretion of oil), sebaceous gland hyperplasia (oil gland enlargement).

Scar refers to the healing of damaged skin. Particularly depressed scar refers to the pathological reaction of the skin such as defect or fibrosis of the dermis after epidermal injury. The method of treating the skin layer using a laser, various chemicals or a dermabrator to remove the defect site, or a method of improving the defect height by subcutaneous cutting (Subcision). However, in the case of dermabrasion treatment, there are many effects on daily life, and the effect of filling the scar is reduced, and Subcision has a reduced effect of accurately aligning the height of the scar due to the viscofibrillation of the scar boundary. It is unsatisfactory in cosmetic after surgery.

In addition, natural changes occur with aging (for example, skin texture, bumps, wrinkles, sagging skin, enlarged pores, etc.). Skin aging is a complex biological process that affects various skin layers, but its main effects are found in the dermis. There are two kinds of independence in biology. And the simultaneous aging process. The first is endogenous aging, which can affect the skin and is likely to affect internal organs. The second is exogenous aging or photoaging, which is the result of exposure to the environment, mainly ultraviolet radiation. The consequences of endogenous aging can be found in the body's skin, including areas that are not exposed to sunlight. In areas exposed to sunlight, especially on the face and back of the hand, photoaging damage and tissue degradation due to endogenous aging work together. Therefore, the most obvious change in the main part of the patient's concern, the facial and neck skin, is the result of a combination of endogenous and exogenous aging processes.

Accordingly, there is a need for an effective procedure or treatment that reduces or eliminates aging changes, permanent defects, discoloration, and/or other scarring.

The present invention provides a system for layered treatment of skin imperfections comprising: a subcision device for cutting a fiber bundle having a skin depth of greater than 1 mm on a target area; and an electromagnetic radiation device for An electromagnetic radiation generated on the target region is applied to skin cells having a skin depth of less than 1 mm. With the aforementioned system, both the improvement of shallow skin leveling and the deep tissue proliferation and filling can be achieved. It can reduce the risk of overuse of a single device, shorten the recovery period and improve the efficacy.

Preferably, the system further comprises a substance introduced into the target area through the subcision device, wherein the substance is selected from the group consisting of growth factors, collagen by-products, collagen Precursors, water acids, vitamins, antioxidants, amino acids, supplemental minerals, platelet-rich plasma, whitening drugs or ingredients, and combinations thereof.

Preferably, the system further comprises an image capturing device, wherein the image capturing device captures the skin on the target area to form a first image and stratifies the skin before the layered treatment of the skin flaw system. After the operation of the system, the image capturing device captures the skin on the target area to form a second image, and compares the first image and the second image to form a reference value.

Preferably, the aforementioned skin mole is selected from the group consisting of: inflammatory skin condition, acne, skin aging, skin relaxation, irregular skin texture, enlarged pores, scars, pigmentation changes, wrinkles, atrophy Skin diseases, congenital skin defects and combinations thereof.

Preferably, the aforementioned electromagnetic radiation source is selected from the group consisting of One: carbon dioxide laser, Er:YAG laser, carbon dioxide shuttle laser (Fractional CO2 laser), 铒 chrome shuttle laser, segmented RF radiation (Fractional RF), shuttle laser (Fraxel), 1550nm shuttle laser and its combination.

Preferably, the electromagnetic radiation source has a light having an energy transfer rate r, wherein r ranges from 0.0013 joules per square centimeter per second ≦r ≦ 0.02 joules per square centimeter per second.

Preferably, the electromagnetic radiation source has a cumulative energy density E (accm) of light, wherein E (accm) ranges from 2.5 joules per square centimeter ≦E (accm) ≦ 20 joules per square centimeter.

Preferably, the aforementioned electromagnetic radiation source has a wavelength of from 9400 nm to 111000 nm.

In summary, the present invention provides a method and system for layered treatment of skin imperfections. The method and system can not only treat the active and invasive scars of the deep and subcutaneous dermis, but also exquisitely sculpt the scar correction of the epidermis and the dermis.

BRIEF DESCRIPTION OF THE DRAWINGS Fig. 1 is a schematic view showing the improvement effect of (A) before treatment (A) and after stratified treatment of skin of the present invention (B); Fig. 2 is a view showing the effect of improving (B) before treatment (A) and using carbon dioxide shuttle laser alone (B) A comparative diagram; Figure 3 is a schematic diagram showing the improvement effect of the treatment (A) and the skin treatment (B) after subcutaneous treatment alone; Fig. 4 is a view showing the treatment of the skin (A) before the treatment (A) and the same day of the present invention (B) A comparison diagram for improving the effect; FIG. 5 is a view showing that after treatment (A) and the same day of the present invention, the skin is layered (B) after 4 A comparison diagram of the tracking improvement effect of the month; FIG. 6 is a schematic diagram showing the comparison of the effect of tracking improvement after one year of treatment (A) and the same day of the present invention (B); FIG. 7 shows the pre-treatment (A) and First, subcutaneously cutting the deep skin for two weeks and then treating the superficial skin with carbon dioxide shuttle (B) to improve the effect; and Figure 8 is to show that before treatment (A) and first use carbon dioxide shuttle to treat the skin layer for two weeks. A schematic diagram comparing the improvement effect of subcutaneous cutting on deep skin (B).

The invention discussed herein is directed to a method and system for layered treatment of skin imperfections. In order to thoroughly understand the present invention, detailed steps and compositions thereof will be set forth in the following description. Obviously, the practice of the invention is not limited to the specific details that are apparent to those skilled in the art. On the other hand, well-known components or steps are not described in detail to avoid unnecessarily limiting the invention. The preferred embodiments of the present invention are described in detail below, but the present invention may be widely practiced in other embodiments, and the scope of the present invention is not limited by the scope of the following patents. .

In a first aspect of the invention there is provided a method of stratifying the treatment of skin imperfections comprising two steps: first, performing a deep skin treatment; and then performing a skin surface treatment procedure. The skin deep treatment system uses a surgical needle to cut a fiber bundle having a skin depth of more than 1 mm on a target area; the skin surface treatment is irradiated with an electromagnetic radiation source on the target area, and the skin depth is less than 1 mm. Skin cells. Preferably, the above steps are performed preferentially by skin deep treatment, and then skin surface treatment is performed, but not limited to the above sequence of steps. In other words, it is also possible to perform skin surface treatment first and then perform deep skin treatment.

The aforementioned deep skin treatment refers to Subcision, which mainly removes the connective tissue under the scar by the tip of the needle, causes blood clots and hematoma, and fills the dent with the fiber proliferation inside the wound. The surgical needle can be treated with a sharp needle or a blunt needle. The needle specifications are divided into 30G, 27G, 25G, 22G, 18G, etc., and the outer diameter is 0.4 mm and the inner diameter is 0.2 mm.

In a possible embodiment, the method of layering treatment of skin imperfections further comprises the step of introducing a substance to the target area, the substance being selected from the group consisting of: growth factors, collagen By-products, collagen precursors, water acids, vitamins, antioxidants, amino acids, supplemental minerals, platelet-rich plasma, whitening drugs or ingredients, and combinations thereof. Preferably, the introduction of a substance means injection filling or fat transplantation. Injection filling is mainly done by injecting collagen and hyaluronic acid to fill, and injecting into the concave part of the dermis to support the skin and restore the elasticity of the skin.

In a feasible embodiment, the method for layering treatment of skin blemishes further comprises performing an analysis step of photographing the skin on the target area with an image capturing device before performing the method of layering the skin blemish. Forming a first image, and after performing the layering method for treating skin flaws, the image capturing device captures the skin on the target area to form a second image, and compares the first image with the second image To form a reference value. The above analysis steps were analyzed by the JANUS II Facial Imaging System (PSI Co, Korea). The image capture device is a 14 megapixel Canon camera. 14 megapixel Canon camera for image capture, using normal light, polarized light and ultraviolet light as the shooting source. The area of the depressed area of the skin was calculated, and the changes of the depressed area before and after treatment were compared. The photo is analyzed by software for pores, wrinkles, skin complexion, UV damage, pigmentation spots The reference value is obtained in comparison with the secretion of oil.

The aforementioned skin surface treatment refers to controlling, by an electromagnetic radiation source, a plurality of small (generally less than 1 mm) individual irradiation areas on the skin tissue to abrade, remove, destroy, damage or stimulate the skin as a treatment for improving the skin. The individual illumination zones can be elliptical, circular, arcuate, and or linear. The electromagnetic radiation source is selected from the group consisting of: carbon dioxide laser, Er:YAG laser, carbon dioxide shuttle laser (Fractional CO2 laser), 铒 chrome shuttle, laser, segmentation RF radiation (Fractional RF), shuttle laser (Fraxel), 1550 nm shuttle laser and combinations thereof. The electromagnetic radiation source has a light having an energy transfer rate r, wherein r ranges from 0.0013 joules per square centimeter per second ≦r ≦ 0.02 joules per square centimeter per second. The electromagnetic radiation source has a cumulative energy density E (accm) of light, wherein E (accm) ranges from 2.5 joules per square centimeter ≦ E (accm) ≦ 20 joules per square centimeter. The electromagnetic radiation source has a wavelength of from 9400 nm to 111000 nm.

In a possible embodiment, the stratified treatment is used to treat the skin sputum of the patient, and the skin sputum is selected from one of the group consisting of: inflammatory skin condition, acne, skin aging, sagging skin, skin Irregular texture, enlarged pores, scars, pigment changes, wrinkles, atrophic skin diseases, congenital skin defects, and combinations thereof.

In a second aspect of the invention there is provided a system for stratifying the treatment of skin imperfections comprising: a subcision device and an electromagnetic radiation device. The subcision device is used to cut a fiber bundle having a skin depth of more than 1 mm on a target area. The electromagnetic radiation device is configured to generate an electromagnetic radiation to illuminate skin cells having a skin depth of less than 1 mm on the target region.

In a possible embodiment, the subcision device mentioned above is selected as a sharp needle or a blunt needle. The needle specifications are divided into 30G, 27G, 25G, 22G, 18G, etc., and the outer diameter is 0.4 mm and the inner diameter is 0.2 mm. The connective tissue under the scar is removed through the needle tip, causing blood clots and hematomas, and the dents are filled by the internal fibrosis of the injured body.

In a possible embodiment, the system for stratifying the skin lice further comprises a substance introduced into the target area through the subcutaneous cutting device described above, wherein the substance is selected from the group consisting of One of the groups: growth factors, collagen by-products, collagen precursors, water acids, vitamins, antioxidants, amino acids, supplemental minerals, platelet-rich plasma, whitening drugs or ingredients Its combination. Preferably, a substance is introduced into collagen or hyaluronic acid, and is injected into the concave portion of the dermis to support the skin to restore elasticity to the skin.

In a possible implementation aspect, the system for layered treatment of skin blemishes further comprises an image capture device for imaging the skin on the target area to form a first image prior to operation of the layered treatment system for skin blemishes. After the system for layering the skin blemishes, the image capturing device captures the skin on the target area to form a second image, and compares the first image with the second image to form a reference value. The image capture device is a 14 megapixel Canon camera. 14 megapixel Canon camera for image capture, using normal light, polarized light and ultraviolet light as the shooting source. The area of the depressed area of the skin was calculated, and the changes of the depressed area before and after treatment were compared. The photographs were analyzed by software, and the reference values were obtained by comparison of pores, wrinkles, skin complexion, ultraviolet rays damage, pigment spots and oil secretion.

In a possible implementation, the electromagnetic radiation source is selected from the following One of the group consisting of: CO2 laser, Er:YAG laser, Fractional CO2 laser, 铬 chrome shuttle, Fractional RF, Shuttle ray Fraxel, 1550nm shuttle laser and combinations thereof. The electromagnetic radiation source has a light having an energy transfer rate r, wherein r ranges from 0.0013 joules per square centimeter per second ≦r ≦ 0.02 joules per square centimeter per second. The electromagnetic radiation source has a cumulative energy density E (accm) of light, wherein E (accm) ranges from 2.5 joules per square centimeter ≦ E (accm) ≦ 20 joules per square centimeter. The electromagnetic radiation source has a wavelength of from 9400 nm to 111000 nm.

In a possible embodiment, the stratified treatment is used to treat the skin sputum of the patient, and the skin sputum is selected from one of the group consisting of: inflammatory skin condition, acne, skin aging, sagging skin, skin Irregular texture, enlarged pores, scars, pigment changes, wrinkles, atrophic skin diseases, congenital skin defects, and combinations thereof.

The term "skin sputum" as used herein includes skin wounds and scars that can occur on any part of the skin of the body (from cosmetic procedures including, but not limited to, breast implants, back, chest center, heart, abdomen, caesarean section) Surgery, pubic area and joint surgery, burns, aging, and photoaging, or wrinkles.

"Scar" is an area of abnormal skin appearance caused by fibrous tissue formation (fibrosis) or sclerosis (eg, scleroderma) in all parts of the body, or normal skin components in various surgical operations, injuries, burns Loss after radiation, chemical exposure, or disease (including various infections). Scar types include, but are not limited to, hypertrophic scars, depressed scars, and stretch marks. When the body produces too much collagen, a hypertrophic scar appears which causes the scar to bulge relative to the surrounding skin. An example of a hypertrophic scar is a scar scar that includes the presence of a defect. Reproduction of fibrous tissue growth after scarring. Atrophic or depressed scars have a concave appearance and are produced when the underlying support structure in the skin is lost. Stretch marks (skin lines) appear when the skin is stretched rapidly (ie, due to a significant increase in body weight or a sharp increase in growth), or when the skin is under tension during healing (usually close to the joint). The term "scar" as used herein encompasses any type of scar from the skin of any cause.

The term "wrinkle" as used herein refers to pleats, ridges, creases in the skin caused by habitual facial expression, loss of collagen and/or elasticity due to aging, sunburn, smoking, hydration, and various other factors. , dents, pits, pits, or recessed areas. Wrinkles range from deep creases to fine lines. Wrinkles appear in any part of the body, specifically the wrinkles expected on the head or neck of the individual. Wrinkles that may be treated in accordance with the present invention include, but are not limited to, heads up, crow's feet, striated lines, one or more fine lines under the eyes or between the eyebrows, and combinations thereof.

As used herein, "treatment" means temporarily or permanently preventing and alleviating (or eliminating) one or more characteristics of the skin imperfections. That is, the size (length, depth, height, and/or width), characteristics, color, and/or texture of the treated skin area is closer to normal tissue. In this regard, the method of treating the skin with the disclosed layering can reduce or improve scarring.

The following specific examples will further describe the method of stratifying the skin blemish of the present invention and its system. The contents shown in the following examples are merely exemplary and are not intended to limit the scope of the invention. It is still within the scope of the present invention to adapt and modify the subject matter of the ordinary skill in the art.

Example 1: Comparison between stratified therapy and individual therapy

As shown in FIGS. 1A and 1B, the present invention is a layered treatment for skin imperfections. The method treats a patient comprising treating the deep skin with subcutaneous cutting and treating the superficial skin with a carbon dioxide shuttle. Figure 1A shows the skin condition before treatment, and Figure 1B shows the skin condition after treatment. In general, the effect of stratified treatment of skin improvement is about 40% to 50%.

As shown in Figs. 2A and 2B, a comparative example in which a patient is treated with a carbon dioxide shuttle laser alone, Fig. 2A shows the skin condition before treatment, and Fig. 2B shows the skin condition after treatment. In general, if the skin scar is a moderate scar, the improvement of the carbon dioxide shuttle laser treatment alone is only about 10% to 20%; if the skin scar is the most serious scars (severe scars) The use of carbon dioxide shuttle laser treatment alone has no significant effect.

As shown in Figures 3A and 3B, the patient was treated subcutaneously using subcision alone, Figure 3A is the skin condition prior to treatment, and Figure 3B is the skin condition after treatment. If the skin scar is a more serious scar to the most severe scars, the effect of subcutaneous treatment alone is only about 20%. From this result, it was apparent that the result of stratified treatment of the skin was superior to the treatment of the skin by using a carbon dioxide shuttle or subcision alone.

Example 2: Effect of using stratified treatment on the same day and several weeks apart

As shown in Figures 4A, 4B, 5A, 5B, 6A and 6B, the patient is treated with a stratified treatment on the same day of the invention. In other words, it refers to the use of subcutaneous cutting to treat deep skin and the treatment of superficial skin with carbon dioxide shuttle in the same day. Figure 4A shows the skin condition before treatment (Grade 2~3), and Figure 4B shows the skin condition after treatment (Grade 1-2). From this result, it can be found that the effect of stratifying the skin on the same day is about 40% to 50%. Figure 5A shows the skin before treatment Skin state (Grade 2), Figure 5B shows the skin state after four months of treatment (Grade 1~2). From this result, it can be found that after 4 months of stratification treatment on the same day, the skin improvement effect is maintained at about 40% to 50%. Fig. 6A shows the skin condition before treatment (Grade 3), and Fig. 6B shows the skin condition after one year of treatment (Grade 2). From this result, it can be found that after one year of stratification treatment of the skin on the same day, the skin improvement effect is maintained at about 40% to 50%.

Figures 7A, 7B, 8A and 8B treat patients in a separate manner using stratified therapy for several weeks. As shown in Figures 7A and 7B, the deep skin was first treated with subcutaneous cutting, and the superficial skin was treated with a carbon dioxide shuttle twice every two weeks. Fig. 7A shows the skin condition before treatment, and Fig. 7B shows the skin condition after treatment. The effect of using stratified treatment for skin improvement at intervals of about 20% to 30%. As shown in Figs. 8A and 8B, the superficial skin was first treated with a carbon dioxide shuttle, and the deep skin was treated with subcutaneous cutting every two weeks. Fig. 8A shows the skin condition before treatment, and Fig. 8B shows the skin condition after treatment. The effect of using stratified treatment for skin improvement at intervals of about 10% to 20%. It was found that the effect of performing carbon dioxide shuttle and subcutaneous cutting of the skin on the same day was better than using a carbon dioxide shuttle and subcutaneous cutting skin for several weeks. If you need to use the interval, the effect of using the subcutaneous cutting and then using the carbon dioxide shuttle is better than using the carbon dioxide shuttle and then using the subcutaneous cutting.

The above-mentioned skin improvement effect quantitative data was subjected to objective evaluation of imaging using the JANUS II Facial Imaging System (PSI Co, Korea). It calculates the area of the depressed area of the skin and compares the changes in the depressed area before and after treatment. It uses a 14 megapixel Canon camera for image capture, using normal light, polarized light and ultraviolet light as the source of light. The photos were analyzed by software for comparison of pores, wrinkles, skin complexion, UV damage, pigment spots and oil secretion.

Obviously, many modifications and differences may be made to the invention in light of the above description. It is therefore to be understood that within the scope of the appended claims, the invention may be The above are only the preferred embodiments of the present invention, and are not intended to limit the scope of the claims of the present invention; all other equivalent changes or modifications which are not departing from the spirit of the present invention should be included in the following claims. Within the scope.

Claims (8)

A layered system for treating skin blemish comprising: a subcision device for cutting a fiber bundle having a skin depth of greater than 1 mm on a target area; and an electromagnetic radiation device for generating an electromagnetic Radiation illuminates skin cells on the target area with a skin depth of less than 1 mm epidermis, and the system is performed sequentially in the same day. The system of claim 1, further comprising a substance introduced into the target area through the subcision device, wherein the substance is selected from the group consisting of: growing Factors, collagen by-products, collagen precursors, water acids, vitamins, antioxidants, amino acids, supplemental minerals, platelet-rich plasma, whitening drugs or ingredients, and combinations thereof. The system of claim 1, further comprising an image capturing device, wherein the image capturing device captures the skin on the target area to form a first image before the layered treatment of the skin flaw system And after the layered treatment of the skin flaw system, the image capturing device captures the skin on the target area to form a second image, and compares the first image and the second image to form a reference value. The system of claim 1, wherein the skin sputum is selected from the group consisting of: inflammatory skin condition, acne, skin aging, sagging skin, irregular skin texture, enlarged pores, Scars, pigment changes, wrinkles, atrophic skin diseases, congenital skin defects and combinations thereof. The system of claim 1, wherein the source of electromagnetic radiation is selected from the group consisting of One of the group consisting of: CO2 laser, Er:YAG laser, Fractional CO2 laser, 铬 chrome shuttle, Fractional RF, Shuttle ray Fraxel, 1550nm shuttle laser and combinations thereof. The system of claim 1, wherein the source of electromagnetic radiation has a light having an energy transfer rate r, wherein r ranges from 0.0013 joules per square centimeter per second ≦r ≦ 0.02 joules per square centimeter per second. The system of claim 1, wherein the electromagnetic radiation source has a cumulative energy density E (accm) of light, wherein E (accm) ranges from 2.5 joules per square centimeter ≦ E (accm) ≦ 20 Joules per square centimeter. The system of claim 1, wherein the electromagnetic radiation source has a wavelength of from 9400 nm to 111000 nm.