TWI618488B - Silica formulation including cashew nut shell liquid or the like,and manufacturing method thereof - Google Patents

Abstract

A cerium oxide preparation containing cashew nut shell liquid, scorpion acid, cardanol or cardanol, and cerium oxide particles, characterized in that the cerium oxide particles adsorb cashew nut shell liquid, scorpion acid, cashew nut The average particle diameter of the phenol or cardanol and the cerium oxide particles is 150 μm or more.

Description

Ceria preparation containing cashew nut shell liquid, etc. and method of producing the same

The present invention relates to a cerium oxide preparation which adsorbs cashew nut shell liquid (CNSL), ruthenium acid, cardanol or cardanol to cerium oxide particles. Further, the present invention relates to a coated granule obtained by coating the surfaces of cerium oxide particles each adsorbing cashew nut shell liquid, such as citron, cardanol or cardanol, and a method for producing the same.

Cashew nut shell liquid is an oily liquid contained in the shell of the fruit of the cashew tree (Anacardium occidentale L.). The components of cashew nut shell liquid mainly include scorpion acid, cardanol, cardanol and methyl cardanol.

The preparation method of the cashew nut shell liquid has a heating method and a solvent extraction method, but in the place where the cashew nut is produced, the cashew nut shell liquid is usually heat-treated, and the like is converted into a cardanol.

Cashew nut shell oil can cause a rash, so you need to be careful. Symptoms of rash can be caused by any of its main components such as citric acid, cardanol and cardanol, so it is necessary to develop safe methods of operation.

Patent Document 1 describes a livestock feed additive: will be derived from chili A volatile substance such as pepper is mixed with an excipient and coated to prevent volatilization. The excipient used in Patent Document 1 is sawdust, and the coagulant is protein and alum.

Patent Document 2 describes a preparation for the purpose of retaining a liquid oil: preparing an aqueous emulsion in oil and absorbing it with a porous oil absorbing material. Patent Document 2 discloses that in order to prevent liquid oil from leaking, the hardened oil and the liquid oil are first uniformly mixed, but the effect is not satisfactory in consideration of the added amount.

Patent Document 3 describes an oil-absorbing preparation in which a functional fat or oil is adsorbed to a carrier such as cerium oxide under reduced pressure. Patent Document 3 describes a disadvantage in that, in order to achieve an effect of speeding up the oil absorption rate, it is necessary to use cerium oxide particles having an average particle diameter of, for example, 5.0 to 10.0 μm.

Patent Document 4 describes that a cerium oxide precursor which improves the rash problem and handling property is successfully produced: an inorganic carrier which adsorbs cashew nut shell liquid or the like to cerium oxide. However, the examples in Patent Document 4 employ cerium oxide particles having an average particle diameter of 100 μm, and do not have an embodiment in which the cashew nut shell oil is adsorbed to the cerium oxide preparation having cerium oxide particles having an average particle diameter of 150 μm or more. Further, in the patent document 4, the ceria particles in which the cashew nut shell oil is adsorbed are not coated.

Patent Document 5 discloses that a cashew nut shell oil is adsorbed to a ceria carrier, and then a granulation and coating step is carried out to obtain a formulation having improved workability and safety. However, the example in Patent Document 5 uses cerium oxide particles having an average particle diameter of 100 μm, and is granulated to a diameter of about 3.0 mm after adsorbing cashew nut shell liquid, and does not adsorb cashew nut shell oil to an average particle diameter of 150 μm or more. An example of a cerium oxide formulation of cerium oxide particles.

The ceria precursor or the ceria formulation in Patent Documents 4 and 5 may precipitate cashew nut shell liquid or the like after standing for a long period of time. And the cashew nut shell liquid is a viscous liquid, which is very difficult to handle because it will cure at about 20 °C. Therefore, there is a need for a technique for improving operability. In addition, since the cashew nut shell oil may be dissolved in contact with moisture or the like, a technique for preventing elution is required.

As described above, a technique of adsorbing cashew nut shell liquid to cerium oxide and a technique of coating particles after granulation have been known so far; however, the cashew nut shell oil is adsorbed to cerium oxide having an average particle diameter of 150 μm or more. Particle cerium dioxide formulations are still not known. Further, a preparation containing a cashew nut shell liquid cerium oxide coated with a coating agent such as a hardened oil without oxidizing or granulating the cerium oxide particles is not known.

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open No. Hei 7-184661

[Patent Document 2] International Publication No. WO2006/137289 Brochure

[Patent Document 3] Japanese Patent Laid-Open Publication No. 2007-209224

[Patent Document 4] International Publication No. WO2009/151048 Booklet

[Patent Document 5] International Publication No. WO2011/013592 Brochure

The present invention is directed to the following matters: prevention of cashew nut shell liquid, ruthenium acid, cardanol or cardanol (hereinafter sometimes referred to as cashew nut shell oil), self-priming (ie, cerium oxide) at low temperature And fixing, improving cashews The fluidity of shell oil and the like, and the prevention of the dissolution of the self-priming carrier such as cashew nut shell liquid, renders the operability of the preparation low.

In other words, the present invention has an object of preventing contact with the skin (safety) and improving workability due to precipitation and dissolution of the cashew nut shell liquid in the preparation.

Moreover, the present invention also aims to simplify the formulation steps.

In order to solve the above problems, the inventors of the present invention have found out that the adsorption of cashew nut shell liquid to cerium oxide having an average particle diameter of 150 μm or more can reduce the precipitation of cashew nut shell liquid.

Further, the present inventors have found that the cashew nut shell oil is adsorbed to cerium oxide (cerium dioxide precursor) having an average particle diameter of 150 μm or more, and further coating treatment can solve problems such as precipitation, dissolution, and rash.

Further, the present inventors have found that the cashew nut shell oil is adsorbed on the ceria at 30 ° C and formulated to reduce the dissolution of the cashew nut shell liquid.

The inventors have finally completed the present invention as described above.

In other words, the invention is as follows:

(1) A cerium oxide preparation containing cashew nut shell liquid, ruthenium acid, cardanol or cardanol, and cerium oxide particles, characterized in that the cerium oxide particles adsorb cashew nut shell liquid, such as citron acid The cardanol diphenol or cardanol has an average particle diameter of 150 μm or more.

(2) The preparation according to (1), wherein the surfaces of the above cerium oxide particles are each coated with a coating agent.

(3) The preparation according to (2), wherein the coating agent is a fatty acid Classes, hardened oils, palm oil or oils derived from these oils.

(4) The preparation according to (3), wherein the coating agent has a melting point higher than 50 °C.

(5) The preparation according to any one of (2) to (4), wherein the coating agent and the coating agent-containing cerium oxide preparation have a mass ratio of 0.1 to 30:100.

(6) The preparation according to any one of (1) to (5) wherein the cerium oxide is characterized in that the oil absorption capacity per 100 g of cerium oxide is 200 g or more.

(7) The preparation according to any one of (1) to (6) for use in feed.

(8) A method for producing a preparation comprising cashew nut shell liquid, a formic acid, cardanol or cardanol, and ceria particles, characterized by comprising cashew nut shell liquid, berry acid, cardanol or a step of adsorbing cardanol to cerium oxide particles having an average particle diameter of 150 μm or more, and cerium oxide particles adsorbing cashew nut shell liquid, ruthenium acid, cardanol or cardanol with a coating agent under heating Stir the mixing step.

(9) A method for producing a preparation comprising a cashew nut shell liquid, a ruthenium acid, a cardanol or a cardanol, and a cerium oxide particle, which comprises a cashew nut shell liquid, a ruthenium acid, or the like at 30 ° C or higher. The step of adsorbing cashew nutdiol or cardanol to cerium oxide particles.

(10) The method according to (9), wherein the cerium oxide particles have an average particle diameter of 150 μm or more.

(11) The method according to (9) or (10), further comprising heating the cerium oxide particles and the coating agent which adsorb the cashew nut shell liquid, the ruthenium acid, the cardanol or the cardanol The step of stirring and mixing is carried out.

By reducing the precipitation, dissolution, and fixation of the cashew nut shell liquid, it is possible to improve the safety and workability at the time of preparation, distribution, and use of the preparation.

Further, if the coating agent is a fatty acid, a hardened oil, palm oil or a fat derived from these oils, water and a solvent may not be used for the coating treatment, and since the drying step can be omitted, the overall engineering can be simplified. Hope to reduce costs.

Further, since the oil absorbing step and the coating step can be carried out in series in the same reaction vessel, the engineering is simplified, and the cost can be reduced.

Fig. 1 is a cross-sectional view (photograph) showing the preparation of the present invention before and after coating.

Fig. 2 is a view (photograph) showing the surface of cerium oxide after the cashew nut shell liquid is absorbed by cerium oxide having an average particle diameter of 110 μm.

Fig. 3 is a view (photograph) showing the surface of cerium oxide after the cashew nut shell liquid is absorbed by cerium oxide having an average particle diameter of 320 μm.

The cerium oxide preparation of the present invention contains cashew nut shell liquid, ruthenium acid, cardanol or cardanol, and cerium oxide particles; cerium oxide particles adsorb cashew nut shell liquid, such as citron, cardanol or cardanol The cerium oxide particles have an average particle diameter of 150 μm or more, and more preferably 250 μm or more. average The upper limit of the particle diameter is not particularly limited, but may be 500 μm. The average particle diameter of cerium oxide can be measured in accordance with the ISO 13320-1 method or the like.

Further, the surface of each of the cerium oxide particles of the cerium oxide preparation of the present invention may be coated with a coating agent.

Moreover, the cerium oxide preparation of the present invention may contain a stabilizer and/or an antioxidant of cashew nut shell liquid.

Further, in the following description, the cerium oxide particles which have been absorbed by the cashew nut shell liquid or the like are referred to as cerium oxide precursors, and the preparation of the cerium cerium oxide precursor coated with the coating agent is called a coating granule, and These are collectively referred to as cerium oxide formulations.

Cashew nut shell liquid is an oily liquid contained in the shell of the fruit of the cashew tree (Anacardium occidentale L.). The components of the cashew nut shell liquid include scorpion acids, cardanol and cardanol. In general, if the acid is heated, it will be converted into cardanol.

According to J. Agric. Food Chem. 2001, 49, 2548-2551, the unheated cashew nut shell oil extracted by pressing the cashew nut shell contains 55 to 80% by mass of cardioic acid and 5 to 20% by mass of cardanol. 5 to 30% by mass with cashew diphenol.

The unheated cashew nut shell oil is 70° C. or higher, more preferably 130° C. or higher, and the heated cashew nut shell liquid obtained after the heat treatment is converted into cashew nuts by the main component of the unheated cashew nut shell oil such as deacidification. Phenol is a substance containing 0 to 10% by mass of a ruthenium acid, 55 to 80% by mass of cardanol, and 5 to 30% by mass of cardanol.

Unheated cashew nut shell oil is often stored at a temperature (20 ° C) for about one year or more, because the main component of the unheated cashew nut shell oil, such as the acid Since carbonyl is converted into cardanol, it is a substance containing 0 to 10% by mass of a ruthenium acid, 55 to 80% by mass of cardanol, and 5 to 30% by mass of cardanol.

Cashew nut shell oil can be obtained by extracting vegetable oil from the shell of pressed cashew nuts. Moreover, cashew nut shell liquid can also be obtained by extraction, such as solvent extraction of cashew nut shells. Further, the cashew nut shell liquid can be obtained by a method described in JP-A-8-231410, for example, a solvent extraction method.

Cashew nut shell oil is also available as a commercial item.

The cashew nut shell liquid of the present invention may be a heated cashew nut shell liquid obtained by heating the unheated cashew nut shell liquid obtained above, at 70 ° C or higher, more preferably at 130 ° C or higher. It may also be a cashew nut shell liquid which is not heated and stored at a temperature (20 ° C) for about one year.

The cashew nut shell liquid of the present invention may also be a cashew nut shell liquid obtained by heat-treating at 130 ° C after being extracted from the cashew nut shell (unheated cashew nut shell liquid).

The cerium oxide preparation of the present invention may contain, for example, a cashew nut shell liquid, a cardanol or a cardanol.

The content of the cashew nut shell liquid in the cerium oxide preparation of the invention is preferably from 10% by mass to 70% by mass based on the total amount of the cerium oxide preparation, preferably from 20% by mass to 65% by mass, and from 30% by mass to 60% by mass. % is better. When the content is 10% by mass or more, the following effects can be efficiently achieved: improvement of rumen fermentation, prevention of bloating, treatment of bloating, treatment of acidosis, prevention of diseases caused by Clostridium, prevention of diseases caused by coccidioides, Improve the milk production of dairy cows, prevent perinatal diseases of dairy cows, improve the reproductive efficiency of dairy cows, and promote the weight gain of livestock. If the content is below 70% by mass, it can be prevented from working. It is preferred to form a rash on the hand and maintain the handleability of the cerium oxide preparation.

As the acid used in the present invention, for example, a natural acid such as a sub-acid, a synthetic hydrazine such as a sub-acid or a derivative thereof can be exemplified. Commercially available hydrazine acids such as citric acid can also be used. For example, as described in JP-A-H08-231410, the cashew nut shell is extracted with an organic solvent, and the obtained cashew nut shell liquid, for example, by changing n-hexane, ethyl acetate, and acetic acid The ratio of the mixed solvent is lysed by a ruthenium column chromatography to obtain a ruthenium acid (see, for example, Japanese Laid-Open Patent Publication No. Hei-3-240721, Japanese Patent Application Laid-Open No. Hei No. Hei No. 3-240716, etc.). This ruthenium acid can be present in the same amount as the cashew nut shell liquid in the cerium oxide preparation, the feed additive and the feed.

The cardanol used in the present invention may, for example, be a natural cardanol, a synthetic cardanol or a derivative thereof. The cardanol used in the present invention can also be obtained by decarbonylating a main component of a cashew nut shell oil such as a sub-acid. This cardanol can be present in the same amount as the cashew nut shell liquid in the ceria formulation, feed additive and feed.

In addition, if the heated cashew nut shell oil is used, the mass ratio of the such as the acid and the cardanol in the cashew nut shell liquid is preferably 0:100 to 20:80.

The cardanol used in the present invention may, for example, be natural cardanol, synthetic cardanol or a derivative thereof. The cardanol diphenol used in the present invention can also be obtained by purifying cashew nut shell liquid.

The cerium oxide preparation of the present invention contains an oil absorbing agent, which is adsorbed by cashew nut shell liquid, ruthenium acid, cardanol or cardanol (hereinafter sometimes referred to as cashew nut shell liquid, etc.) and is contained in the oil absorbing agent. In the cerium oxide preparation of the present invention, the oil absorbing agent is cerium oxide and has an average particle diameter of 150 μm or more. And The oil absorbing agent in the present invention preferably contains 200 g or more of oil per 100 g. The oil absorption capacity of the cerium oxide (the amount of oil adsorbed, also referred to as the oil absorption) can be measured by the ISO 787/5 method or the like.

The cerium oxide preparation of the present invention may also contain a stabilizer and/or an antioxidant such as cashew nut shell liquid. The stabilizer of the cashew nut shell liquid or the like used in the present invention refers to a multidentate ligand chelating agent which forms a chelate compound with a metal ion contained in the cashew nut shell liquid or the like.

The chelating agent used in the present invention is exemplified by an organic acid, an organic acid salt, a phosphoric acid, a phosphate, an aminopolycarboxylic acid, an aminopolycarbonate, a neutral amino acid, and an aluminum hydrazine. Acid salts, phosphonic acids, phosphonates, polymers.

Examples of chelating agents for organic acids and organic acid salts include: citric acid and its salts, malic acid and its salts, tartaric acid and its salts, succinic acid and its salts, gluconic acid and its salts, Oxalic acid and its salts, glycolic acid and its salts, and propionic acid and its salts.

Phosphates and phosphate chelating agents include, for example, orthophosphoric acid and salts thereof, pyrophosphoric acid and salts thereof, tripolyphosphoric acid and salts thereof, tetrapolyphosphoric acid and salts thereof, hexametaphosphoric acid and salts thereof. Classes as well as phytic acid and its salts. Examples of the orthophosphates include sodium dihydrogen phosphate, potassium dihydrogen phosphate, ammonium dihydrogen phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, and diammonium hydrogen phosphate. Examples of the chelating agent of the aminopolycarboxylic acid and the aminopolycarbonate are: ethylenediaminetetraacetic acid (EDTA) and salts thereof, ethylenediaminediacetic acid and salts thereof, and hydroxyethylethylenediamine. Tetraacetic acid and its salts, diethylenetriamine pentaacetic acid and its salts, nitrogen triacetic acid and its salts, triethylenetetramine hexaacetic acid and its salts, dicarbonyl methyl bran Amidamine hexaacetic acid and its salts, dicarbonylmethyl glutamic acid tetrasodium salt, dimethylol glycine acid, 1,3-propanediaminetetraacetic acid and its salts, 1,3-diamine-2 -Hydroxypropane tetraacetic acid and its salts, phosphonic acid butane tricarboxylic acid and its salts, glutamic acid and its salts, cyclohexanediaminetetraacetic acid and its salts, imine diacetic acid and its salts , N-(2-hydroxyethyl)imine diacetic acid and its salts, N-(2-hydroxyethyl)ethylenediaminetriacetic acid and its salts, ethylene glycol diethyl ether diamine tetraacetic acid and salts thereof , glutamic acid diacetic acid and its salts, aspartic acid diacetic acid and its salts and dimethylol glycine.

Examples of chelating agents for neutral amino acids include glycine, alanine, leucine, cysteine, methionine, aspartic acid and glutamic acid.

The chelating agent of the aluminosilicate is exemplified by zeolite.

Examples of the chelating agents of phosphonic acid and phosphonates include hydroxyethyl diphosphonic acid and salts thereof, nitrogen trimethylene phosphonic acid and salts thereof, nitrile groups and salts thereof.

Polymeric chelating agents are exemplified by polyacrylic acid, polymaleic acid, and copolymers of maleic acid and acrylic acid. It is also possible to use two or more chelating agents at the same time.

Examples of the antioxidants such as cashew nut shell liquid used in the present invention include: ethoxyquin, t-butylhydroxytoluene, t-butylhydroxymethoxybenzene, tributylhydroquinone, ascorbic acid and its esters, and vitamins. E, gallic acid and its esters, isoascorbic acid, chlorogenic acid, sulfite, thiosulfate, phosphite, hypophosphite and phosphate. It is also possible to use two or more antioxidants at the same time.

The cerium oxide preparation of the present invention can be obtained by adsorbing cashew nut shell liquid or the like to cerium oxide having an average particle diameter of 150 μm or more (oil absorption step); however, the cerium oxide preparation of the present invention adsorbs cashew nut shell oil or the like. Preferably, the cerium oxide precursor obtained after the cerium oxide having an average particle diameter of 150 μm or more is coated with a coating agent (coating step).

The coated granules of the present invention can be obtained, for example, in the following manner.

The cerium oxide particles having an average particle diameter of 150 μm or more (other oil absorbing agents as needed) and cashew nut shell liquid are mixed (and a stabilizer and/or an antioxidant are added as needed). Thereafter, cerium oxide particles (cerium dioxide precursor) to which cashew nut shell liquid or the like is adsorbed are coated with a coating agent under heating as needed.

In the present invention, after the oil absorption, the granulation and the granulation treatment are not carried out, and the coating agent may be coated as needed to obtain the coated granule of the invention.

The coating agent to be used in the present invention is, for example, a fat or oil such as a hardened oil, palm oil, a fatty acid, a paraffin wax or a wax; and the above coating agent may be used in two or more types, and the above coating agent may also be used. mixture.

The hardening oil used in the present invention is exemplified by a vegetable hardening oil such as soybean hardening oil, palm hardening oil, and rapeseed hardened oil, as long as it can release cashew nut shell liquid, such as cranberry acid, cardanol and cashew nuts. There is no limit to phenol.

The fatty acids used in the present invention are, for example, saturated fatty acids having a melting point higher than 50 ° C, and more particularly, for example, saturated fatty acids having more than 14 carbon atoms such as myristic acid, palmitic acid and stearic acid. And esters thereof, as long as they can release cashew nut shell liquid, such as acid, cardanol and cardanol, there is no limit.

The coating agent used in the present invention preferably has a melting point of higher than 50 °C. Further, the coating agent used in the present invention is preferably 0.01 to 50% by mass, more preferably 0.05 to 40% by mass, even more preferably 0.1 to 30% by mass based on the total mass of the coating granule.

In the coated granule of the present invention, the mass ratio of the cerium oxide particles to the coating agent is preferably from 80 to 99.9:20 to 0.1.

The apparatus used in the oil absorption treatment and the coating treatment in the present invention is not particularly limited, and examples thereof include a mixer such as a paddle mixer, a ribbon blender, a rocking mixer, and a cone mixer. Further, in the present invention, the oil absorbing step and the coating step may be carried out continuously in the same vessel or separately. That is, as long as the cerium oxide is mixed with the cashew nut shell oil, the cashew nut shell oil is adsorbed to the cerium oxide, and after the adsorption, the coating agent is added, and the cerium oxide adsorbing the cashew nut shell liquid and the coating agent are mixed under heating. The surface of the cerium oxide may be coated.

Further, in the production method of the present invention, when the oil or fat melted under heating is used as a coating agent, it is not necessary to use a solvent, and a drying step is not required.

The production method of the present invention may be carried out under normal pressure or reduced pressure.

Further, in the production method of the present invention, the oil absorption step may be carried out at a normal temperature, but in consideration of the oil absorption efficiency, it is recommended to heat to between 20 and 100 ° C, preferably between 30 and 80 ° C, and preferably between 40 and 80 ° C. Better between.

In the present invention, it is known that cashew nut shell liquid, ruthenium-like acid, cardanol and cardanol are adsorbed to cerium oxide particles at a temperature of 30 ° C or higher and formulated to reduce the active ingredients of cashew nut shell liquid and the like. Dissolution. This effect It is not limited to the case of using cerium oxide having an average particle diameter of 150 μm or more.

Accordingly, the present invention is a process for producing a preparation containing cashew nut shell liquid, a nutrient acid, a cardanol, a cardanol and a ceria particle, and also comprises a cashew nut shell liquid, a nutrient acid, a cardanol It is related to the production method of the step of adsorbing to the ceria particles at a temperature above 30 ° C (preferably 30 to 80 ° C, preferably 40 to 80 ° C).

The coating step is preferably adjusted to match the melting point of the coating agent. The heating temperature at the time of adding the coating agent may be as long as it exceeds the melting point, but it is preferably 5 to 50 ° C higher than the melting point of the coating agent to be used.

When the coating agent is used for the coating treatment, it can be carried out by using the above apparatus, specifically, the following steps.

‧ The cashew nut shell liquid or the like is adsorbed to the cerium oxide particles having an average particle diameter of 150 μm or more.

‧ Add an appropriate amount of coating agent to the cerium oxide particles (cerium dioxide precursor) to which cashew nut shell liquid or the like is adsorbed, and stir and mix at an appropriate temperature.

‧ After mixing and mixing, cool the coated cerium oxide particles as needed.

The cerium oxide preparation of the invention is suitable for: a rumen fermentation improving agent for ruminants, a bulging prophylactic agent, a bulging therapeutic agent, a gastric augmentation shifting therapeutic agent, a acid poisoning therapeutic agent, a control agent for diseases caused by Clostridium, The control agent for the disease caused by the bacterium, the effect of increasing the milk yield of the cow, the effect of preventing the perinatal disease of the cow, the effect of improving the reproductive efficiency of the cow, and the promoter of the weight gain of the livestock. Moreover, the cerium oxide preparation can also be added as a feed. Use of the agent.

The feed additive of the present invention is not particularly limited as long as it contains the cerium oxide preparation of the present invention. In addition to this, it may further contain an optional component which promotes the growth of the ruminant, the nutrient replenishing component, and the component which improves the preservation stability. Examples of any of such components include: bacteria of the genus Aspergillus, bacteria of the genus Bacillus, bacteria of the genus Bifidobacterium; enzymes such as amylase and lipase; L-ascorbic acid and choline chloride , vitamins such as inositol, folic acid; minerals such as potassium chloride, ferric citrate, magnesium oxide, phosphate; DL-alanine, DL-methionine, L-lysine, etc. Amino acid; organic acids such as fumaric acid, butyric acid, lactic acid, acetic acid and salts thereof; ethoxyquin, dibutylhydroxytoluene, butylhydroxymethoxybenzene, ferulic acid, vitamin C, vitamin E Antioxidants such as; fungicides such as calcium propionate; adhesives such as carboxymethyl averaverin (CMC), casein sodium, sodium polyacrylate; lecithin, glycerin fatty acid ester, sorbitan fat Emulsifiers such as acid esters; pigments such as astaxanthin and scutellaria; flavors such as various esters, ethers, and ketones.

Further, the feed additive of the present invention can be mixed with other feed ingredients which are usually used as a feed to form a feed. The type of feed and the ingredients other than the ceria preparation are not particularly limited.

In the case of the feed of the present invention, in the case of ruminants such as cows, goats, and sheep, the feed amount can be appropriately adjusted according to the animal's type, body weight, age, sex, health condition, and feed composition. The cashew nut shell liquid contained in the feed is preferably 0.005~500g/head ‧ days, 0.05~100g/head ‧ days is better, 0.5~50g/head ‧ days is better

The method of feeding and feeding methods can be carried out according to the commonly used methods of animal species.

[Examples] 1. Extraction of unheated cashew nut shell liquid

From Cashew Nut Co., Ltd., 500 kg of cashew nut shell was obtained, and 158 kg of cashew nut shell liquid (unheated CNSL) was pressed.

The composition of the cashew nut shell liquid was measured by the following method. That is, using: HPLC (Waters 600, Japan Waters Co., Ltd.), testing machine (Waters 490E, Japan Waters Co., Ltd.), printing machine (Chromatopac C-R6A, Shimadzu Corporation), pipe column (Supelcosil LC 18, Supelco, Inc). The analysis conditions were as follows: The solvent was acetonitrile: water: acetic acid was 80:20:1 (volume ratio), the flow rate was 2 ml/min, and the absorbance at 280 nm was measured.

The unheated cashew nut shell liquid contains, for example, 61.8% by mass of the acid, 8.2% by mass of the cardanol, and 19.9% by weight of the cashew nut.

2. Preparation of cerium oxide preparation

(1) Cerium oxide uses the following products of Evonik, Rhodia and Oriental Silicas Corporation. However, the numerical values of the average particle diameters are the values on the company catalogues.

[Table 1]

(2) The coating agent is the following product of the pure pure drug and the cross-cut grease.

(3) Cashew nut shell oil

The cashew nut shell is obtained from the cashew nut trading company as described above, and is pressed into cashew nut shell liquid.

(4) Oil absorption step

A 300 ml three-neck separable flask equipped with a dropping funnel and paddle stirring blades was set.

52 g of cerium oxide of each particle diameter shown in Table 1 was placed in a flask and heated to a predetermined temperature in a warm water bath. While stirring, 68 g of cashew nut shell liquid contained in a funnel was dropped over a period of about 40 minutes. Stirring was continued for 5 minutes after the completion of the dropping, and the oil absorption step was completed (Production Example 1).

(5) Consistent manufacturing (coating step)

Adding to the cerium oxide precursor after the end of the (4) oil absorption step 24g of crushed palm hardened oil (horizontal oil products), while mixing, mix well. After immersing in a warm water bath of 70 ° C and stirring for 10 minutes, the same stirring was continued and cooling, and the coating step was completed (Production Example 2).

(6) Separate manufacturing (coating step)

The granules containing the cashew nut shell liquid produced in the above (4) oil absorbing step are used, and the coating granules are produced by using various coating agents. A small amount of the coating step was carried out using a 500 ml flask by rotating the flask in a warm water bath.

Specifically, 10 g of cerium oxide-containing cerium oxide produced by the above (4) oil absorbing step, and 2 g of various coating agents which were pulverized were placed in a 500 ml flask, and the flask was rotated to be uniformly mixed. Next, the warm water bath temperature was set to a melting point suitable for the applied coating agent, and the flask was immersed in a warm water bath for about 10 minutes to carry out a coating step. According to this method, a preparation prepared by coating with six kinds of coating agents (lauric acid, myristic acid, palmitic acid, stearic acid, palm hardening oil, soybean hardening oil) listed in Table 2 was produced (manufacturing example 3~) 8).

3. Performance evaluation (1) Electron microscopy analysis

Figure 1 shows an electron micrograph of the prepared preparation. It can be ascertained from the figure that the coating layer is formed by coating treatment.

(2) Precipitation confirmation test of cerium oxide (Example 1)

Various cerium oxide preparations (Table 1) of Production Example 1 (oil absorption temperature: 40 ° C) were allowed to stand at 4 ° C for 4 days. After confirming whether the surface of each of the cerium oxide has a waist The shell oil was precipitated (Table 3).

According to Fig. 2, it was confirmed that the surface of the ceria having an average particle diameter of 110 μm had precipitation of cashew nut shell liquid. On the contrary, cerium oxide having an average particle diameter of 170 μm, 250 μm and 320 μm was absent (Fig. 3).

(3) Evaluation of dissolvability of cashew nut shell oil of various coated granules (Example 2 (oil absorption temperature 40 ° C))

1 g of the above-mentioned 2. cerium oxide preparations The various coating granules prepared in the preparations (4) and (6) (cerium oxide using Sipernat 2200) were added to 40 ml of water, and allowed to stand at 20 ° C for 1 hour. Next, the coated granules were recovered, and the cashew nut shell liquid remaining in the granules was extracted with ethyl acetate, and the amount of dissolution was calculated. The results are shown in Table 4.

[Table 4]

Table 4 shows that the material having a higher melting point than myristic acid has a superior effect of inhibiting the dissolution. The ability of the coating agent to inhibit the detachment may be related to the melting point of the coating agent.

(4) Evaluation of dissolvability of cashew nut shell liquid of various cerium oxides (Example 3 (oil absorption temperature 25 ° C))

The coated granules were produced from palm hardened oil in the same manner as in the above preparations (2) and (5) of the above-mentioned 2. cerium oxide preparation.

The various granules prepared by this method were subjected to the evaluation of the solvency in the same manner as in the above-mentioned 3. Performance Evaluation (3) except that the standing time was 15 minutes. The results are shown in Table 5.

[table 5]

As is apparent from Table 5, a cerium oxide preparation having an effect of suppressing the dissolution can be produced regardless of which cerium oxide is used.

(5) Evaluation of the dissolving properties of cashew nut shell liquid of cerium oxide at various oil absorption temperatures (Example 4)

For the various cerium oxide preparations of Production Example 1, the solute evaluation was carried out in the same manner as in the above-mentioned 3. Performance Evaluation (3) except that the standing time for the evaluation of the solubility was 15 minutes. The results are shown in Table 6. However, the evaluation of the oil absorption temperature is between 20 and 80 °C.

Dissolution evaluation of cashew nut shell liquid - Dissolution rate of cashew nut shell oil adsorbed to various cerium oxide at different oil absorption temperatures -

[Table 6]

It can be seen from Table 6 that regardless of which cerium oxide is used, as long as the oil absorption temperature is set to 30 ° C or higher, the cashew nut shell oil can be significantly inhibited from the dissolution of the preparation; increasing the particle size of the added cerium oxide can further suppress the dissolution.

(6) Evaluation of the dissolvability of cashew nut shell liquid of coating agents at various oil absorption temperatures (Example 5)

The coated granules were produced from palm hardened oil in the same manner as in the above preparations (2) and (5) of the above-mentioned 2. cerium oxide preparation. However, the oil absorption temperature is between 25 ° C and 50 ° C.

The various granules prepared by this method were subjected to the evaluation of the solvency in the same manner as in the above-mentioned 3. Performance Evaluation (3) except that the standing time was 15 minutes. The results are shown in Table 7.

Dissolution evaluation of cashew nut shell liquid -Adsorption of cashew nut shell oil at different oil absorption temperatures, and the elution rate when treated with a coating agent -

As can be seen from Table 7, the increase in the oil absorption temperature and the treatment with the coating agent can further suppress the solubility.

[Possibility of industrial use]

According to the present invention, a cerium oxide preparation such as a cashew nut shell liquid having improved safety and workability can be provided. Further, according to the present invention, a simplified method for producing a coated granule can be provided. The formulations of the invention and methods for their manufacture are useful in the livestock sector.

Claims (12)

A cerium oxide preparation containing cashew nut shell liquid, scorpion acid, cardanol or cardanol, and cerium oxide particles, characterized in that the cerium oxide particles adsorb cashew nut shell liquid, scorpion acid, cashew nut The average particle diameter of the phenol or cardanol and the cerium oxide particles is 150 μm or more. The preparation according to claim 1, wherein the surface of the above cerium oxide particles is coated with a coating agent. The preparation according to claim 2, wherein the coating agent is a fatty acid, a hardened oil, palm oil or a fat derived from these oils. The preparation of claim 3, wherein the coating agent has a melting point higher than 50 °C. The preparation according to claim 2, wherein the coating agent and the coating agent-containing cerium oxide preparation have a mass ratio of 0.1 to 30:100. The preparation according to any one of claims 1 to 5, wherein the cerium oxide is characterized in that the oil absorbing ability per 100 g of cerium oxide is 200 g or more. The preparation according to claim 6 is for use in feed. A method for producing a preparation comprising cashew nut shell liquid, ruthenium acid, cardanol or cardanol, and cerium oxide particles, characterized by comprising adsorbing cashew nut shell liquid, ruthenium acid, cardanol or cardanol a step of cerium oxide particles having an average particle diameter of 150 μm or more, and a cerium oxide particle adsorbing cashew nut shell liquid, a berry acid, a cardanol or a cardanol, and a coating agent are stirred and mixed under heating step. A method for producing a preparation comprising cashew nut shell liquid, a scorpion acid, a cardanol or a cardanol, and a cerium oxide particle, which comprises a cashew nut shell liquid, a citron nut acid, a cardanol at 30 ° C or higher Or the step of adsorbing cardanol to cerium oxide particles. The method according to claim 9, wherein the cerium oxide particles have an average particle diameter of 150 μm or more. The method according to claim 9 or 10, further comprising the step of stirring and mixing the ceria particles adsorbed with cashew nut shell liquid, such as citron, cardanol or cardanol with a coating agent under heating. A preparation method of a preparation containing cashew nut shell liquid, a nutrient acid, a cardanol or a cardanol and a ceria particle, which comprises adsorbing cashew nut shell liquid, ruthenium acid, cardanol or cardanol A step of cerium oxide particles having an average particle diameter of 150 μm or more.