TWI603712B - Cardiac Physiological Measurement System - Google Patents

Description

Cardiac physiology measurement system

The present invention relates to a measurement system for a physiological state, and more particularly to a measurement system for cardiac pulsation physiology.

Cardiovascular disease has always been the number one killer of global population deaths. According to data published by the World Health Organization, cardiovascular disease causes approximately 17.1 million deaths worldwide each year, accounting for 31% of the world's total deaths. 7.4 million people died of heart disease, and it is estimated that by 2030 the global death toll will climb to 23 million per year. There are many reasons that affect the normal physiological function of the heart, including the degree of patency of the blood vessels of the heart, the contraction of the heart muscle, the movement of the heart valve, the stability of the stimulation of the sinus node, and the blood flow of the cardiovascular, etc., and slight differences may be applied to humans. Life poses a great threat. Therefore, in the prevention or treatment of heart disease, many instruments for monitoring different cardiac physiological reactions have recently been developed, including electrocardiogram, heart sound map, cardiac ultrasound, positron tomography or nuclear medicine examination. With the expectation of more accurate grasp of the most immediate physiological conditions of the heart, doctors and patients can carry out the most effective response measures or treatments in the first time.

Among them, although the electrocardiogram is one of the most widely used cardiac physiological measuring instruments, the electrocardiogram is used to reflect the overall symptoms of the heart and its valves. It can only infer the operation of the heart valve, and cannot use the ECG alone to observe the heart. The abnormal symptoms of the valve, so it is still in some specific heart diseases, especially for heart failure, Valvular Heart Disease and Syncope. The limitations, while other detection methods can not effectively improve the existing limitations, such as heart sound map can only be used to determine the opening and closing time of the heart valve, can not be used to determine the blood flow changes caused by valvular heart disease caused by the overall function of the heart, and heart sounds The sound received by the picture comes from the body surface, which makes it doubtful about time delay, or the chest X-ray photography can diagnose the calcification of the valve, but it is an image output method that cannot be monitored for a long time. In addition, the ultrasound is also Can be used to observe the heart image and its tissue movements, however, the M-type cardiac ultrasound system can only be used to determine The diameter of the visceral lumen and the movement of the heart valve, while the Doppler ultrasound and contrast ultrasound can only measure the direction of blood flow, flow velocity and turbulence in the blood vessels of the heart, and can only observe two-dimensional The directional restriction of the planar state can not be used as a better choice for the monitoring of valvular heart disease, while the three-dimensional ultrasound can observe the whole picture of the heart beat, but it is not only expensive, but also the output image consumes heavy software resources, lacking The convenience of long-term monitoring.

Mechanocardiography (MCG) is a kind of detection method for observing cardiac physiology by measuring the vibration sequence signal transmitted to the body during the heart beat. Because of the heartbeat and blood in the heartbeat process The movement of the flow and the valve will cause the corresponding recoil pressure to the surface of the body. Therefore, the heart map can be measured by the kinetic energy sensor such as an accelerometer on the body surface to measure the recoil pressure, and the heart and ventricle are shot. Blood ability, atrial filling speed during diastole, and opening and closing of the valve were observed, and the physiological state of the heart beat was evaluated. As shown in the invention patent application of CN101801263A, the electrocardiogram can be observed simultaneously by a set of Electrocardiogram (ECG) modules and a set of Mechanocardiography (MCG) modules. After the R wave peak caused by the depolarization of the ventricular muscle tissue is synchronized with the time sequence of the corresponding heart map, the corresponding feature points of the heart beat state are obtained on the heart map.

However, in the existing cardiogram measurement technology, a plurality of inertial motion sensors are disposed on the body surface corresponding to the tricuspid valve for measurement, and the inertial motion sensor is measured in this manner. At the time, the measurable heartbeat feature points will be limited to the cardiac physiological phenomenon around the tricuspid valve, which is limited in number, which is one; in addition, when performing cardiac physiological measurement in this way, It can not accurately measure the exact movement of the distal valve and the blood flow, which is easy to cause misunderstanding and omission of the measured value; three, under the current technology, the heartbeat feature points The acquisition method is only based on the synchronization of the ECG and the heartbeat timing, and the interpretation of the waveform of the heartplate is performed according to the theory. The analysis cannot be performed together with other effective information sources, so the richness and accuracy of the feature points are insufficient. .

Based on the above reasons, how to provide a measurement system for heart-beating maps, so that doctors and users can not only obtain the physiological state of heart beat more accurately, but also transform more effective information sources to jointly judge and judge, that is, under the current conditions There is an urgent need for breakthroughs in this technical field.

The main purpose of the present invention is to provide a heart beat physiological measurement system for a plurality of heart vibration sources, wherein a signal database is connected to the signal receiving comparison module, and the database is used to capture at least one heartbeat signal. A feature point to observe the physiological state of the heart beat, wherein the database is established by using a plurality of feature points obtained by the heartbeat signal, the electrocardiogram and the cardiac ultrasound comparison, and the cardiac physiological monitoring can be performed effectively and rapidly. .

Another object of the present invention is to provide a cardiac pulsation physiological measurement system for a plurality of cardiac vibration sources, wherein an acceleration sensor is provided for a specific cardiac vibration source to obtain a more accurate valve motion state, myocardial contraction strength, and blood pulse velocity at each specific position. The size and comparison of the heartbeat feature points and eigenvalues between specific locations to eliminate the single heartbeat signal from obscuring the reading of missing specific feature points due to insufficient signal source, resulting in the inaccuracy of the heart beat measurement.

A further object of the present invention is to provide a cardiac pulsation physiological measurement system combining ultrasonic feature points, which is used to determine the characteristic points and characteristic parameters of the cardiac vibration map by combining the feature point algorithm, thereby avoiding the image subject interpretation being too subjective. More breakthrough in the current clinical examination of valve opening and closing, myocardial contraction and abnormal blood pulse must be synchronized with ultrasound or nuclear magnetic examination to determine the lack.

Another object of the present invention is to provide a cardiac physiology measurement system for a plurality of cardiac vibration sources, which collects a vibration response of a "face" during a heartbeat by collecting a plurality of cardiac image signals into a cardiac shock spectrum. Dynamic observation and identification of valve opening and closing time, abnormal opening and closing action, myocardial contraction intensity and blood pulse velocity in the cardiac actuation cycle, in order to overcome the single heart map, the heart beat measurement is not accurate due to time delay and signal attenuation. Disadvantages.

Another object of the present invention is to provide a heart beat physiological measurement system, which combines the measurement system with wearable technology or portable technology to develop a mobile heart for use in homes and hospitals. The pulsating feature point measurement system provides a more objective auxiliary judgment, making it suitable for different application scenarios, and is convenient for doctors and users to apply.

In order to achieve the above object, the present invention discloses a cardiac pulsation physiological measurement system, which is a heartbeat state database established by using a plurality of feature points obtained by comparison of a cardiac map, an electrocardiogram and a cardiac ultrasound. The utility model comprises a plurality of electrocardiographic measuring electrodes, at least one inertial motion sensor and a signal receiving comparison module. The electrocardiographic measuring electrodes are attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal, and the at least one inertial motion sensor is disposed at a position corresponding to the heart valve to be measured. At least one integrated measurement area for sensing at least one acceleration measurement signal, and then the signal reception comparison module respectively receives the electrocardiogram signal and the at least one acceleration measurement signal, and converts the at least one acceleration measurement signal into at least Synchronizing the signal after the heartbeat signal, and using the electrocardiogram signal to generate a starting point on the at least one heartbeat signal, wherein the starting point compares the database with at least one of the at least one heartbeat signal Feature points.

In an embodiment of the present invention, the measurement system of the cardiac pulsation physiology further includes a transmission unit and a terminal device; the transmission unit is connectable with the signal comparison module for receiving the comparison result. And the data is transmitted to the terminal device for data presentation or advanced processing.

In an embodiment of the present invention, it is also disclosed that the body surface region comprises a second rib of the left sternal border crossing the sternum stem to the right, and extending to the aortic valve surface region between the second and third intercostals of the right sternal border; The fifth intercostal space of the right sternal border extends to the mitral valve surface area of the posterior tibial line; the second intercostal space between the left sternal border is centered, and extends upward to the first intercostal space, the left subclavian area, and down to the left sternal left edge. The intercostal pulmonary valve surface area; or the tricuspid valve surface area extending from the fourth and fifth intercostals of the right sternal border to the right.

In an embodiment of the present invention, it is also disclosed that the electrocardiographic measuring electrodes and the inertial motion sensors can be further disposed on the inner side of the intimate garment, and are also disposed on at least one integrated table region corresponding to the position of the heart valve, and the heart is performed. The measurement of the seismic spectrum.

In addition, the present invention also discloses a measurement system of cardiac pulsation physiology, which uses a plurality of feature points obtained by comparing a heartbeat map, an electrocardiogram and a cardiac ultrasound, and takes a characteristic point time difference obtained by at least two feature points and a band thereof. Slope, the established heartbeat state database, the system comprising a plurality of electrocardiographic measuring electrodes, at least one inertial motion sensor and a signal receiving comparison module. The electrocardiographic measuring electrodes are attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal, and the at least one inertial motion sensor is disposed at a position corresponding to the heart valve to be measured. At least one integrated measurement area for sensing at least one acceleration measurement signal, and then the signal reception comparison module respectively receives the ECG signal and the at least one acceleration measurement signal, and converts the at least one acceleration measurement signal into After the at least one heartbeat signal is synchronized, the ECG signal and the acceleration measurement signals are synchronized, and the ECG signal is used to generate a starting point on the at least one heartbeat signal, and the starting point is compared with a database. Obtaining at least two feature points on the at least one heartbeat signal to obtain a time difference or a range slope of the at least two feature points.

In an embodiment of the present invention, the heartbeat physiological measurement system is also disclosed. When the number of the inertial motion sensors is at least two inertial motion sensors, the system further includes a heartbeat signal processing module. a group connected between the inertial motion sensor and the signal receiving comparison module for receiving at least two acceleration measurement signals, and superimposing the acceleration measurement signals to generate a three-dimensional heart vibration After the signal is transmitted, it is transmitted to the signal synchronization module.

In an embodiment of the present invention, it is also disclosed that the time difference of the at least two feature points is a time elapsed time from when the valve is opened to the maximum blood flow of the valve, when the blood flow of the pulse is maximum, when the valve is closed, or when the valve is opened to the valve. total time.

In an embodiment of the present invention, it is also disclosed that the slope of the interval of the at least two feature points is a slope of an increasing segment of the blood flow velocity or a slope of a decreasing segment of the blood flow velocity.

In an embodiment of the present invention, the time difference of the at least two feature points is the total time from the mitral valve opening to the mitral valve closure, the total time from the tricuspid valve opening to the tricuspid valve closing, and the pulmonary artery. Total time from valve opening to pulmonary valve closure, total aortic valve opening to aortic valve closure, total tricuspid valve closure to total pulmonary valve opening, total mitral valve closure to aortic valve opening, mitral valve The time to the maximum flow of the mitral valve venous flow, the time of the tricuspid valve opening to the maximum time of the tricuspid valve blood flow, the time of the aortic valve opening to the maximum flow of the aortic valve, the time of the pulmonary valve The time to the maximum flow of blood to the pulmonary artery valvular, the time of mitral valvular blood flow to the time of mitral valve closure, the maximum time of tricuspid valvular blood flow to the time of tricuspid valve closure, pulmonary artery The maximum time of valvular blood flow to the time of pulmonary valve closure or the time when the aortic valve blood flow is maximum to the time of aortic valve closure

In an embodiment of the present invention, it is also disclosed that the slope of the segment of the at least two feature points is an increasing segment of the mitral valve blood flow velocity, an increasing segment of the tricuspid valve blood flow velocity, and an increase in the pulmonary valve blood flow velocity. Segmental, aortic valve blood flow velocity increased, mitral valve blood flow velocity decreased, tricuspid valve blood flow velocity decreased, pulmonary valve blood flow velocity decreased segment or aortic valve blood flow velocity decreased segment .

In addition, the present invention also discloses a heart beat physiological measurement system, which comprises a plurality of electrocardiographic measurement electrodes, at least one inertial motion sensor and a signal receiving comparison module. The electrocardiographic measuring electrodes are attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal, and the at least one inertial motion sensor is disposed at a position corresponding to the heart valve to be measured. The at least one integrated area is configured to sense at least one acceleration measurement signal, and then the signal receiving comparison module respectively receives the electrocardiogram signal and the at least one acceleration measurement signal, and the ECG signal and the at least one acceleration Measuring the signal, converting the at least one acceleration measurement signal into at least one heartbeat signal, and then synchronizing, and generating at least one starting point on the at least one heartbeat signal by using the electrocardiogram signal, and receiving the comparison mode At least one feature point is captured by the algorithm on the at least one heartbeat signal according to the at least one starting point, wherein the algorithm is based on the starting point on the time axis of the at least one heartbeat signal A target time range performs the capture of the at least one feature point.

In an embodiment of the present invention, the algorithm further includes: generating a first starting point on the aortic valve heartbeat signal by using the R wave peak on the electrocardiogram, 0.06 seconds after the first starting point A peak point is obtained after a minimum valley point, and the peak point is defined as a maximum velocity characteristic point of the sidewall myocardial contraction; a maximum peak point is extracted within 0.07 seconds to 0.1 seconds after the first starting point, The maximum peak point defines the maximum characteristic point of aortic valve blood flow; a second starting point is generated on the electrocardiogram R wave peak on the pulmonary valve heartbeat signal, 0.07 seconds to 0.1 second after the second starting point A maximum peak point is taken internally, and the maximum peak point is defined as a characteristic point of the maximum speed of myocardial contraction in the middle; one of the above or any combination thereof.

In addition, the present invention also discloses a heart beat physiological measurement system, which comprises a plurality of electrocardiographic measurement electrodes, at least one inertial motion sensor and a signal receiving comparison module. The electrocardiographic measuring electrodes are attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal, and the at least one inertial motion sensor is disposed at a position corresponding to the heart valve to be measured. The at least one integrated area is configured to sense at least one acceleration measurement signal, and then the signal receiving comparison module respectively receives the electrocardiogram signal and the at least one acceleration measurement signal, and the ECG signal and the at least one acceleration Measuring the signal, converting the at least one acceleration measurement signal into at least one heartbeat signal, and then synchronizing, and generating at least one starting point on the at least one heartbeat signal by using the electrocardiogram signal, and receiving the comparison mode The algorithm extracts at least one feature point on the at least one heartbeat signal according to the at least one starting point, wherein the algorithm uses the starting point as a reference on the time axis of the at least one heartbeat signal. The ECG signal generates at least one corresponding point on the at least one heartbeat signal, and the at least one starting point and the at least one corresponding point are performed to the A feature point of capture.

In an embodiment of the present invention, the algorithm further comprises: generating a first corresponding point on the aortic valve heartbeat signal by using a P wave peak on the electrocardiogram, and the R wave peak on the electrocardiogram is in the aorta A first starting point is generated on the heartbeat signal, and a maximum peak point is drawn between the first starting point and the first corresponding point, and the maximum peak point is defined as the maximum characteristic of the mitral atrial contraction blood flow Pointing; or generating a second corresponding point on the aortic valve heartbeat signal on the electrocardiogram, and extracting a maximum peak point from 0.1 second to the second corresponding point after the first starting point, The maximum peak point is defined as the largest characteristic point of pulmonary valve blood flow; one of the above or any combination thereof.

In addition, the present invention also discloses a heart beat physiological measurement system, which comprises a plurality of electrocardiographic measurement electrodes, at least one inertial motion sensor and a signal receiving comparison module. The electrocardiographic measuring electrodes are attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal, and the at least one inertial motion sensor is disposed at a position corresponding to the heart valve to be measured. The at least one integrated area is configured to sense at least one acceleration measurement signal, and then the signal receiving comparison module respectively receives the electrocardiogram signal and the at least one acceleration measurement signal, and the ECG signal and the at least one acceleration Measuring the signal, converting the at least one acceleration measurement signal into at least one heartbeat signal, and then synchronizing, and using the electrocardiogram signal to generate at least one starting point on the at least one heartbeat signal, the signal receiving comparison module Obtaining at least two feature points on the at least one heartbeat signal according to the starting point by an algorithm, obtaining a time difference or a section slope of the at least two feature points.

In an embodiment of the present invention, it is also disclosed that the feature points are selected from a maximum feature point of a mitral atrial contraction blood flow, a side wall myocardial contraction maximum velocity feature point, and an aortic valve blood flow maximum feature point. One of the maximum velocity characteristic points of myocardial contraction, one of the largest characteristic points of pulmonary valve blood flow, or any combination thereof.

In an embodiment of the present invention, it is also disclosed that the slope of the interval of the at least two feature points is a slope of an increasing segment of the blood flow velocity or a slope of a decreasing segment of the blood flow velocity.

In an embodiment of the present invention, the algorithm further comprises: capturing a maximum feature point of the mitral atrial constricted blood flow and a trough point before the feature point on the at least one heartbeat signal, and calculating two points The slope of the connection is used as an increasing rate of blood flow velocity of the mitral valve; the maximum characteristic point of the mitral atrial constricted blood flow and one trough point after the characteristic point are obtained on the at least one cardiac image signal, and two points are calculated. The slope of the connection is used as the deceleration rate of the mitral valve blood flow velocity; the maximum characteristic point of the aortic valve atrial constricted blood flow and one of the trough points before the characteristic point are obtained on the at least one cardiac image signal, and two points are calculated. The slope of the connection is used as an increasing rate of aortic valve blood flow velocity; the maximum characteristic point of the aortic valve atrial contraction blood flow and one trough point after the characteristic point are obtained from the at least one cardiac image signal, and two points are calculated. The slope of the connection is used as the deceleration rate of the aortic valve blood flow velocity; the maximum characteristic point of the atrial systolic blood flow of the pulmonary valve and the trough point before the characteristic point are captured on the at least one cardiac image signal Calculating the slope of the two-point line as an increasing rate of pulmonary valve blood flow velocity; or extracting the maximum characteristic point of the pulmonary valve atrial constricted blood flow and one of the trough points after the characteristic point on the at least one cardiac image signal, The slope of the two-point line is used as a deceleration rate of the pulmonary valve blood flow velocity; one of the above or any combination thereof.

In order to provide a better understanding and understanding of the features and the efficacies of the present invention, the preferred embodiment and the detailed description are as follows:

In the present invention, in view of the current measurement of the heartbeat state by the tricuspid heartbeat signal, the accuracy of the valve movement state, myocardial contraction strength and blood pulse velocity is misaligned and rich. Insufficient circumstances provide a novel cardiac pulsation physiological measurement system. By means of this system, a plurality of cardiac maps can be received at a plurality of specific locations and a cardiac map can be formed, and the characteristics of physiological states such as valve motion state, myocardial contraction strength and blood pulse velocity can be obtained by using the map. Points and characteristic parameters to improve the accuracy of the heartbeat map, and by comparing a plurality of different psychocardiograms to obtain a more accurate time difference of the feature points, to further monitor the actuation state of the specific valve; In addition, the heartbeat physiological measurement system provided by the present invention has further combined the information of the heartbeat state database established by the plurality of feature points obtained by the comparison of the heart rate map, the electrocardiogram and the cardiac ultrasound, thereby The combination of the heartbeat signal and the existing information obtained by the measurement can not only provide more accurate measurement results, but also can be used in daily inspections with expensive and inconvenient ultrasonic monitoring instruments. .

Therefore, the present invention provides a novel heartbeat physiology measuring system, which is provided with a plurality of sets of acceleration sensing signals to obtain a plurality of heartbeat signals by means of a plurality of cardiac vibration sources. The heart vibration source directly monitors the heartbeat signal and monitors it at the same time, overcoming the shortcomings of single position measurement, which is easy to be accurate due to time delay and signal attenuation, and is obtained by comparing different cardiac vibration sources. The heartbeat signal can be used to interpret the heartbeat physiological response with more direct and accurate signals, increase the accuracy of cardiac physiological monitoring, and provide a heartbeat database with built-in ultrasound information combined with cardiac ultrasound. Compared with the cardiogram obtained from a plurality of cardiac vibration sources, it can not only identify more physiological features that can only be measured by ECG and heart map, but also without ultrasonic examination. In the case, it is a system for identifying whether the physiological phenomenon such as opening and closing of the heart, myocardial contraction, and blood flow pulse is different from the normal mode.

The components, properties, and manners of the heartbeat physiology measurement system of the present invention are further described below:

Please refer to the first figure and the second figure, which are schematic structural diagrams and circuit blocks of the measuring device of the cardiac pulsation physiological measuring system according to the first embodiment of the present invention. As shown in the figure, the present invention provides a cardiac pulsating physiology. The measuring system includes a plurality of electrocardiographic measuring electrodes 20 attached to a plurality of measuring portions of a subject 10 to sense and generate an electrocardiogram signal, and at least one inertial motion sensor 30. The system is disposed at least one integrated surface area corresponding to the position of the heart valve of the subject 10 for sensing at least one acceleration measurement signal, and the plurality of electrocardiographic measurement electrodes 20 and the at least one inertial motion sensor 30 The first signal receiving comparison module 40 is connected to the first signal receiving comparison module 40. After the ECG signal and the acceleration measuring signal are transmitted to the first signal receiving comparison module 40, the at least one acceleration measuring signal forms at least one heartbeat signal. And the at least one heartbeat signal is synchronized with the timing of the ECG signal, and the ECG signal generates a starting point on the at least one heartbeat signal, The first ultrasound database 401 is matched with the starting point, and at least one feature point can be extracted from the cardiac image. The first database 401 used by the system is a cardiac shock. The heartbeat state database established by the plurality of feature points obtained by the comparison of the electrocardiogram and the cardiac ultrasound.

According to the first embodiment of the present invention, the electrocardiographic measurement electrode 20 is disposed on a limb conductor measurement area for introducing a current to measure the heart beat of the heart. During the cycle, depolarization fluctuations are transmitted from the sinus node cells to the atria, and then transmitted to the ventricles via the internal conduction pathway, and the minute voltage changes sensed between the electrodes are recorded as the voltage measurement signal. . The electrocardiographic measuring electrodes 20 are suitable for the position of the setting, generally about ten places. However, in actual operation, the electrocardiographic measuring electrodes 20 are set according to different lead requirements, wherein Preferably, it is a three-limb guide position setting, which includes a right hand RA, a left hand LA and a left foot LL, and the better one is located on the upper edge of the wrist and the ankle, as shown in the first figure. The relative position is not limited to this. In addition, after obtaining the voltage signals, the electrocardiographic measuring electrodes 20 can filter the number of frequencies required to form the electrocardiogram signal by using the functions of noise reduction and filtering, or further adjust the frequency capturing range according to the required conditions, for example, In the case of monitoring, the high frequency limit and low frequency limit of the signal capture can be set to a narrower range to avoid unnecessary interference of noise. Conversely, when the diagnosis is made, the signal can be captured. The high frequency limit and the low frequency limit are widened to receive more signal values and to grasp more subtle heart beat changes.

The heartbeat physiology measuring system according to the first embodiment of the present invention, wherein the inertial motion sensors 30 are sensors having an accelerometer chip, and the common types include piezoresistive accelerometer chips and capacitors. An accelerometer chip, a piezoelectric accelerometer chip, and a resonant accelerometer chip, which are disposed around the heart to capture acceleration changes caused by the cardiac cycle of the heart around the heart. The acceleration changes are caused by heart valve opening and closing, myocardial contraction, and cardiac vascular compression. The vibration caused by the heart beats, and the vibration generated by the vibration can be further formed by collecting the acceleration signals generated by the vibrations. A continuous pattern of acceleration changes, the continuous pattern of acceleration changes can be called a Mechano cardiography (MCG), or a cardiogram (Beglistocardiograph, BEG), and the generated heart map can be used to represent the heart beat through auxiliary judgment. The physiological state of the cycle.

As described in the above paragraph, the positions of the inertial motion sensors 30 are preferably disposed on the body surface area corresponding to the four heart valves of the heart, and the body surface areas include: the left edge of the sternum The second rib extends across the sternum stem to the right, extending to the aortic valve surface region 11 between the second and third intercostals of the right sternal border; and extending from the fifth intercostal space of the right sternal border to the mitral valve surface region 12 of the posterior tibial line Centered on the second intercostal space of the left sternal border, extending upward to the first intercostal space, the left subclavian area, down to the third intercostal space of the third intercostal sternal border; and the fourth and fifth intercostal space from the right sternal border The tricuspid valve surface area 14 is expanded to the right, but the positions of the inertial motion sensors 30 are not limited thereto.

According to the first embodiment of the present invention, the first signal receiving and analysing module 40 is provided with at least one microprocessor for performing the electrocardiogram signal and at least one acceleration. The processing of the measurement signal, wherein the first signal receiving and comparing module 40 can perform the PQRST peak or valley point for the electrocardiogram signal transmitted by the electrocardiographic measuring electrodes 20, preferably for the The P wave, the R wave, and the T wave of the electrocardiogram signal are captured, and the first signal receiving comparison module 40 is firstly received from the at least one acceleration measuring signal transmitted from the at least one inertial motion sensor 30. Converting it into at least one heartbeat signal, and then comparing at least one heartbeat signal monitored at the same time as the P-wave of the electrocardiogram signal, as a starting point of the at least one heartbeat signal interpretation, and the T wave with the electrocardiogram signal The at least one heartbeat signal monitored at the same time serves as an end point, forming a synchronization interval as a basis for synchronizing the continuous acceleration signal (cardiac signal) and the ECG signal, and The two signals are synchronized for subsequent comparison.

The first signal receiving and comparing module 40 is further connected to a first database 401, so that the first signal receiving and comparing module 40 synchronizes the at least one heartbeat signal and the ECG signal. And obtaining, by the first database 401, a cardiac image data for comparing the synchronized signals, wherein the cardiac image data is obtained by comparing the cardiac image, the electrocardiogram and the cardiac ultrasound. The feature points, and the physiological significance of the heart beat represented by the feature points. The first signal receiving comparison module 40 compares the data of the first database 401 with the synchronized at least one heartbeat signal and the ECG signal, and simultaneously generates a position with the closest feature point or characteristic parameter. The heart map is taken as a target, and at least one feature point is obtained from the at least one heart map after the comparison to observe the heartbeat physiological state of the subject. The first data library 401 and the first signal receiving comparison module 40 may be connected to the first signal receiving comparison module 40 in the form of a chip, or in a wireless communication manner. The first signal receiving comparison module 40 is connected, but the manner in which the first database 401 and the first signal receiving comparison module 40 are connected is not limited thereto.

As described above, the first signal receiving comparison module 40 provided by the present invention is connected to the first database 401 which is a cardiogram data which is compared with the electrocardiogram and the cardiac ultrasound, and the plural number defined by the same. Feature points, the established heartbeat state reference database. The method for obtaining the first database 401 is to synchronize the ECG signal measured by the electrocardiographic measuring electrode and the acceleration sensor with the heartbeat signal, and then compare with the measuring signal obtained by the cardiac ultrasonic wave. The heartbeat feature points obtained by the heartbeat map at the corresponding time points are defined by the cardiac pulsation state represented by the cardiac ultrasound, and the information about the feature points and all the signal maps is collected.

For the content of the above paragraph, please refer to the third figure, which is a characteristic point ratio of the heartbeat, electrocardiogram and cardiac ultrasound map in a preferred embodiment of the method for obtaining the feature points of the first database 401 provided by the present invention. For the schematic diagram, in this embodiment, a first inertial motion sensor is disposed on one of the aortic valve surface regions corresponding to the heart valve, and the first inertial motion sensor is received by the aortic valve body. The surface of the table is transmitted from the heart beat to the vibration of the body surface, and generates an aortic heartbeat signal. The aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the second right edge of the sternum. At the same time, a first cardiac inductance measuring module is arranged to receive an electrophysiological signal of the heart beat on the measuring portion of the limb conductor, to generate a first electrocardiogram signal, and then to capture a P wave of the first electrocardiogram signal. a point and an R peak point, and the P peak point and the R peak point respectively corresponding to the aortic heartbeat signal generate a first corresponding point and a second corresponding point, and the first electrocardiogram signal and the main Arterial heartbeat The horizontal axis of the number is time dependent, and finally the maximum peak point from the first corresponding point to the second corresponding point is obtained. After obtaining a cardiac ultrasound map and confirming the comparison, determining the maximum peak point is The largest characteristic point of atrial systolic blood flow in a cusp.

For the content of the above paragraph, please refer to the fourth figure, which is a characteristic point of the heartbeat, electrocardiogram and cardiac ultrasound map in another preferred embodiment of the method for obtaining the feature point of the first database 401 provided by the present invention. In another embodiment, a first inertial motion sensor can be disposed on an aortic valve surface region corresponding to the heart valve, and the first inertial motion sensor receives the aortic valve. The surface of the body surface is transmitted from the heart beat to the vibration of the body surface, and an aortic heartbeat signal is generated. The aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the right edge of the sternum. And a three-ribbed device, at the same time, a first cardiac inductance measuring module is arranged to receive an electrophysiological signal of the heart beat on the measuring portion of the limb conductor to generate a first electrocardiogram signal, and then one of the first electrocardiogram signals is captured. a peak point and an R peak point, and the R peak point corresponding to the aorta heartbeat signal generates a second corresponding point, and the first electrocardiogram signal and the horizontal axis of the aortic heartbeat signal are time dependent, Final capture a minimum valley point within 0.06 seconds after the second corresponding point and a peak point after the minimum valley point, after obtaining a cardiac ultrasound map and confirming the alignment, the peak point indicates a side wall myocardial contraction Maximum speed feature point.

For the content of the above paragraph, please refer to the fifth figure, which is a characteristic point of the heartbeat, electrocardiogram and cardiac ultrasound map in another preferred embodiment of the method for obtaining the feature point of the first database 401 provided by the present invention. In another embodiment, a first inertial motion sensor can be disposed on an aortic valve surface region corresponding to the heart valve, and the first inertial motion sensor receives the aortic valve. The surface of the body surface is transmitted from the heart beat to the vibration of the body surface, and an aortic heartbeat signal is generated. The aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the right edge of the sternum. And a three-ribbed device, at the same time, a first cardiac inductance measuring module is configured to receive an electrophysiological signal of the heart beat on the measurement area of the limb conductor, generate a first electrocardiogram signal, and then extract an R peak point on the electrocardiogram, and Corresponding to the aortic heartbeat signal to generate a second corresponding point, and the first electrocardiogram signal and the horizontal axis of the aorta heartbeat signal are time dependent, and finally the second corresponding point is obtained. After 0.07 The maximum peak point to one of 0.1 seconds, after obtaining a map of the heart and comparing ultrasound confirmed that the maximum peak point represents a point wherein the maximum aortic blood flow.

For the content of the above paragraph, please refer to the sixth figure, which is a preferred embodiment of the method for obtaining the feature points of the first database 401 provided by the present invention, and the characteristic point ratio of the heartbeat, electrocardiogram and cardiac ultrasound maps. For another embodiment, a first inertial motion sensor can be disposed on an aortic valve surface region corresponding to a heart valve, and the first inertial motion sensor receives the aortic valve body. The surface of the table is transmitted from the heart beat to the vibration of the body surface, and generates an aortic heartbeat signal. The aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the second right edge of the sternum. At the same time, a first cardiac inductance measuring module is arranged to receive an electrophysiological signal of the heart beat on the measuring portion of the limb conductor to generate a first electrocardiogram signal, and one of the R peak points on the first electrocardiogram signal is captured. And a T peak point, wherein the R peak point and the T peak point respectively correspond to the aorta heartbeat signal to generate a second corresponding point and a third corresponding point, and the first electrocardiogram signal and the aortic heart Transverse signal The axis time is dependent, and finally one of the maximum peak points from 0.07 seconds to 0.1 seconds after the third corresponding point is obtained. After obtaining a cardiac ultrasound map and confirming the comparison, the maximum peak point represents a pulmonary valve blood flow. The largest feature point.

For the content of the above paragraph, please refer to the seventh figure, which is a characteristic point of the heartbeat, electrocardiogram and cardiac ultrasound map in another preferred embodiment of the method for obtaining the feature point of the first database 401 provided by the present invention. In another embodiment, a second inertial motion sensor can be disposed on a pulmonary valve surface region corresponding to one of the heart valves, and the second inertial motion sensor is received on the pulmonary valve surface table. The region is transmitted from the heart beat to the vibration of the body surface to generate a pulmonary artery heartbeat signal, wherein the pulmonary valve body surface region includes the second rib of the left sternal border and extends upward to the first intercostal space, the left subclavian region and extends downward. To the third intercostal space of the left edge of the sternum, a first cardiac inductance measuring module is arranged to receive the electrophysiological signal of the heart beat on the measurement area of the limb conductor to generate a first electrocardiogram signal, and then the first electrocardiogram signal is captured. And an R peak point, and the R peak point corresponding to the pulmonary artery heartbeat signal generates a fourth corresponding point, and the first ECG signal and the horizontal axis time of the pulmonary artery heartbeat signal Depending on, one of the maximum peak points from 0.07 seconds to 0.1 seconds after the fourth corresponding point is obtained. After obtaining a cardiac ultrasound map and confirming the comparison, the maximum peak point indicates the maximum speed of myocardial contraction. Feature points.

For the content of the above paragraph, please refer to the eighth figure, which is another preferred embodiment of the method for obtaining the feature points of the first database 401 provided by the present invention, and the characteristic point ratio of the heart motion map, the electrocardiogram and the cardiac ultrasound map. For another embodiment, a second inertial motion sensor can be disposed on a pulmonary valve surface region corresponding to one of the heart valves, and the second inertial motion sensor is received in the pulmonary valve surface region. From the heartbeat to the vibration of the body surface, a pulmonary artery heartbeat signal is generated, wherein the pulmonary valve body surface region includes the second intercostal space of the left sternal border and extends upward to the first intercostal space, the left subclavian region and extends downward to The third intercostal space of the left sternal border is provided with a first cardiac inductance measuring module to receive an electrophysiological signal of the heart beat on the measurement area of the limb conductor, and generate a first electrocardiogram signal, which is captured on the first electrocardiogram signal. An R peak point, wherein the R peak point corresponds to the pulmonary artery heartbeat signal to generate a fourth corresponding point, and the first electrocardiogram signal and the horizontal axis of the pulmonary artery heartbeat signal are time dependent, most Taking the second peak point taken from the time interval of 0.085 seconds to 0.15 seconds after the fourth corresponding point, after obtaining a cardiac ultrasound map and confirming the comparison, the peak point represents a pulmonary valve blood flow The largest feature point.

For the content of the above paragraph, please refer to the ninth figure, which is a characteristic point of the heartbeat, electrocardiogram and cardiac ultrasound map in another preferred embodiment of the method for obtaining the feature point of the first database 401 provided by the present invention. In another embodiment, a third inertial motion sensor can be disposed on a mitral valve surface region corresponding to one of the heart valves, and the third inertial motion sensor receives the mitral valve The surface of the valve body is transmitted from the heart beat to the vibration of the body surface, and generates a mitral heart motion signal, wherein the mitral valve surface region includes a fifth rib of the right sternal border extending to the posterior iliac line, and a first The cardiac inductance measuring module receives the electrophysiological signal of the heart beat on the measurement area of the limb conductor, generates a first electrocardiogram signal, and then extracts an R peak point of the first electrocardiogram signal, and corresponding the R peak point Generating a fifth corresponding point in the mitral heartbeat signal, and the first electrocardiogram signal and the horizontal axis time of the mitral heartbeat signal are dependent, and finally 0.02 seconds before the fifth corresponding point The second peak point, Obtaining a map and echocardiogram confirmed, it is determined that the maximum peak point is a feature point of maximum atrial contraction mitral blood comparison.

For the content of the above paragraph, please refer to the tenth figure, which is a characteristic point of the heartbeat, electrocardiogram and cardiac ultrasound map in another preferred embodiment of the method for obtaining the feature point of the first database 401 provided by the present invention. In another embodiment, a third inertial motion sensor can be disposed on a mitral valve surface region corresponding to one of the heart valves, and the third inertial motion sensor receives the mitral valve The surface of the valve body is transmitted from the heart beat to the vibration of the body surface, and generates a mitral heart motion signal, wherein the mitral valve surface region includes a fifth rib of the right sternal border extending to the posterior iliac line, and a first The cardiac inductance measuring module receives the electrophysiological signal of the heart beat on the measurement area of the limb conductor, generates a first electrocardiogram signal, and then extracts an R peak point of the first electrocardiogram signal, and corresponding the R peak point The fifth cusp of the mitral heartbeat signal generates a fifth corresponding point, and the ECG and the horizontal axis of the mitral heartbeat signal are time dependent, and finally between 0.05 and 0.11 seconds after the fifth corresponding point One of the largest peak points Echocardiography After a confirmation pattern and ratio of the peak point represents a maximum lateral myocardial contraction speed feature point.

For the content of the above paragraph, please refer to the eleventh figure, which is a characteristic of the heartbeat, electrocardiogram and cardiac ultrasound map in another preferred embodiment of the method for obtaining the feature points of the first database 401 provided by the present invention. In another embodiment, a fourth inertial motion sensor can be disposed on a tricuspid valve surface region corresponding to one of the heart valves, and the fourth inertial motion sensor receives the three-pointed sensor. The surface of the valve body is transmitted from the heart beat to the vibration of the body surface, and generates a tricuspid heart motion signal, wherein the tricuspid valve surface region includes the fourth and fifth ribs of the right sternal border extending to the right, and a first The cardiac inductance measuring module receives the electrophysiological signal of the heart beat on the measurement area of the limb conductor, generates a first electrocardiogram signal, and then extracts one R peak point on the first electrocardiogram signal, and makes the R peak point Corresponding to the tricuspid heartbeat signal, a sixth corresponding point is generated, and the first electrocardiogram signal and the horizontal axis of the tricuspid heartbeat signal are dependent on each other, and finally the second corresponding point is 0.05 seconds. The second peak to 0.11 second At the point of value, after obtaining a cardiac ultrasound map and confirming the alignment, the maximum peak point represents a maximum velocity characteristic point of myocardial contraction.

The feature point obtaining method of the above embodiment is summarized, wherein the ECG signal measured by the electrocardiographic measuring electrode and the acceleration sensor is synchronized with the heartbeat signal, and then compared with the measuring signal obtained by the cardiac ultrasonic wave. The corresponding relationship between the heartbeat state of the blood flow through the maximum amount of the valve and the maximum myocardial contraction is obtained in the heartbeat feature point. However, the feature points of the feature point obtaining method provided by the present invention are not limited thereto. The heartbeat state of the heart valve opening and closing, or the minimum amount of blood flowing through the valve can be defined by the feature point acquisition method provided by the present invention and included in the collection of the database.

The following is a further description of the heartbeat physiological measurement system provided by the present invention according to the difference between the database and the prior art. Please refer to the twelfth A picture and the twelfth B picture, which are separate three The valvular heartbeat signal and the four heart valve heartbeat signals provided by the present invention, the measurement signal diagram and the schematic diagram of the characteristic point extraction thereof, as shown in the twelfth A diagram, the corresponding body of the tricuspid valve The heartbeat signal measured in the table area is the most common type of heartbeat signal in the prior art. With its peak points and peaks and valleys, the aortic valve opening, aortic valve closing, and apex can be performed. Cardiac pulsation states such as valve opening are defined. However, as shown in Figure 12B, there are still many heartbeat state feature points that cannot be peaked and peak-valley in the tricuspid heartbeat signal. Presenting, but these heartbeat state feature points can be clearly presented in the heartbeat signal measured by other valves, such as the pulmonary valve obtained from the pulmonary valve heartbeat signal comparison. The maximum characteristic point of blood flow, the characteristic point of maximal velocity of myocardial contraction obtained from the comparison of the signal of the mitral valve heartbeat, and the maximum characteristic point of mitral blood flow obtained from the comparison of the signal of the mitral heartbeat The tricuspid heartbeat signal is obtained by comparing the maximal velocity characteristic points of the myocardial contraction and the maximum characteristic point of the aortic valve blood flow obtained from the aortic valve heartbeat signal. In the heart-to-heart map, the transition from peak to trough is in an excessively dense peak region. Therefore, the tricuspid heartbeat signal cannot be judged on the characteristic points of the heart beat state, or the error rate is high when discriminating. In addition, the heartbeat state feature points measured by the prior art tricuspid heartbeat signal are measured at a single position to measure the physiological state of all heart beats, and thus occur when located far from the tricuspid valve. When the heartbeat physiological state produces a signal to the body surface position corresponding to the tricuspid valve, the delay of the measurement time or the weakening of the signal strength due to the distance factor also causes the judgment error to occur. The feature points of the aortic valve opening and closing or the feature points of the mitral valve opening and closing are currently judged and defined by the tricuspid valve heartbeat signal. However, the judgment result and actual condition of the tricuspid valve heartbeat signal There is still considerable error. In view of the above, the heartbeat physiological measurement system provided by the present invention is a heartbeat state database established by using a plurality of feature points obtained by comparing a heartbeat map, an electrocardiogram and a cardiac ultrasound, in the heartbeat physiological monitoring. Having a higher degree of accuracy, so that the at least one heartbeat signal and the ECG signal synchronized by the first data receiving and comparing module 40 are connected to the first data bank 401 and the signals are compared. At the same time, more and more accurate heartbeat state feature points can be obtained than the existing cardiac pulsation physiological measurement system.

Further, the first database 401 provided by the present invention may acquire at least one feature point on the at least one heartbeat signal, and may be based on the time axis of the at least one heartbeat signal. Selecting a specific time to obtain the at least one feature point, or overlapping the at least one heartbeat signal with one of the database heartbeat signals in the first database 401, and using a plurality of data The library feature point corresponds to a position corresponding to one of the at least one cardiogram signal to obtain the at least one feature point, but the method used in the present invention should not be limited thereto.

Further clinical data is provided below to explain the manner and content of the database comparison using the heartbeat physiological measurement system provided by the present invention. Please refer to the thirteenth Ath and thirteenth Bth drawings, which are the electrocardiogram signals of the heart beat physiological measurement system provided by the present invention for normal people and heart diseases, and measured in the mitral valve body surface area. Mitral valve heartbeat signal. As shown in the figure, the cardiac pulsation physiological measurement system provided by the present invention can utilize the mitral valve heartbeat signal measured by the mitral valve body surface region to the maximum velocity characteristic point and the cusp of the myocardial contraction of the user's side wall. The flap closure time was observed as an aid to the judgment of the heart beat state. Comparing the 13th and 13th B pictures, it can be further found that the R-peak of the electrocardiogram corresponds to the mitral heart rate map of the normal person and the heart disease in the comparison of the mitral heartbeat signal. The time difference between the time point of the signal and the characteristic point of the maximal velocity of the myocardial contraction of the lateral wall (△T), the average patient of the valvular heart disease is 2.5 microseconds (ms) more than the normal person, and at the same time, the maximum speed of myocardial contraction of the lateral wall In terms of the amplitude intensity difference (ΔA) of the feature points, the average patient of the valvular heart disease is also 5.3 mG lower than that of the normal person, and the feature points acquired by the heartbeat physiological measurement system provided by the present invention are apparent. It is indeed possible to compare the abnormalities of the heartbeat physiology as an indicator of cardiac pulsation observation and monitoring.

Please refer to FIG. 14 , which is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the first embodiment of the present invention. As shown in the figure, the measurement of cardiac pulsation physiology provided by the present invention is shown. The system may further be provided with a transmission unit 50 and a terminal device 60. The transmission unit may be connected to the first signal receiving comparison module 40 for receiving the comparison result after the comparison with the first database 401, the ECG signal and the at least one heartbeat signal for data transmission. The terminal device 60 is configured to receive one of the data transmitted by the transmission unit 50, and perform rendering or advanced processing of the data. The transmission unit 50 can be connected to the terminal device 60 by wire or wirelessly. For example, the transmission unit 50 can be a wireless communication chip, a USB port, or a serial line port. In addition, the terminal device 60 is a device for receiving data transmitted by the transmission unit 50 by wire or wirelessly for image presentation, by which the user can use text, data or graphics. The image presentation can be obtained more quickly and in detail to obtain the results obtained by the measurement system provided by the present invention. Moreover, the present invention can be implemented by the micro processing unit (not shown) of the terminal device 60. Further processing the data transmitted by the transmission unit 50 includes performing data comparison, massive analysis, data storage, or uploading data to the cloud system, so that the functions of the measurement system can be more diverse.

With the arrangement of the transmission unit 50 and the terminal device 60, the cardiac pulsation physiological measurement system provided by the present invention can be obtained by using a cardiogram, an electrocardiogram and a cardiac ultrasound comparison at a lower hardware requirement. The heartbeat state database established by the plurality of feature points performs the heartbeat map measurement having the same effect as the cardiac ultrasound measurement, that is, the heartbeat physiological measurement system provided by the present invention can be provided for use. High-precision and high-accuracy cardiac physiology monitoring is performed at home or regional hospitals to improve cardiac function-assisted judgment without the need to purchase expensive and cumbersome cardiac ultrasound measuring instruments. The convenience of the system achieves the goal of medical popularization.

Referring to FIG. 15 , which is a structural diagram of a wearable device of a cardiac pulsation physiological measurement system according to a first embodiment of the present invention, as shown, the wearable device includes a first wearing portion 70 and a second The wearing part 80 and the at least one connecting unit 90, wherein the first wearing part 70 is adjacent to the side of the user body, and includes a plurality of electrocardiographic measuring electrodes 20 and at least one inertial motion sensor 30 for detecting the user. The ECG signal and the acceleration measurement signal, the second wear unit 80 includes a first signal receiving comparison module 40 for receiving the electrocardiogram signal and the acceleration measurement signal, and using the heart rate map, the electrocardiogram and the heart Ultrasonic comparison of the plurality of feature points obtained by the plurality of feature points to perform signal synchronization and feature point capture; further, one of the at least one connection unit is connected to the first wear portion 70 The electrocardiographic measuring electrode 20 and the at least one inertial motion sensor 30 are connected to the first signal receiving comparison module 40 of the first wearing portion 80, so as to be measured ECG signals and acceleration measurement signal transmitted to the signal reception ratio of a first module 40 and the synchronization signal of the specific feature point. By combining the heartbeat physiological measurement system provided by the invention with the wearable device, the measurement system can be used to achieve the physiological monitoring target of anytime, anywhere, follow-up and carry-on, and can play an abnormal warning and therapeutic evaluation in the home care. The important role is more widely used in all corners of medical care.

Hereinafter, another cardiac pulsation physiological measurement system and method thereof according to the present invention will be described. Please refer to FIG. 16 , which is a measurement of a cardiac pulsation physiological measurement system according to a second embodiment of the present invention. Block diagram of the device circuit, as shown in the figure, the embodiment has a plurality of electrocardiographic measuring electrodes 20 and at least one inertial motion sensor 30 for monitoring the physiological state of the heart, wherein the electrocardiographic measuring electrodes 20 and the at least one The setting of the inertial motion sensor 30 and its functions are the same as those of the first embodiment, and thus will not be described herein.

Referring to FIG. 16 , the second signal receiving comparison module 41 provided in this embodiment is also provided with at least one microprocessor for processing the electrocardiogram signal and the at least one acceleration measuring signal. The second signal receiving comparison module 41 performs the steps of integrating the at least one signal acceleration measurement signal into at least one heartbeat signal and synchronizing the at least one heartbeat signal and the electrocardiogram signal with the first embodiment. The second signal receiving comparison module 41 is further connected to a second database 411, so that the second signal receiving comparison module 41 synchronizes the at least one heartbeat. After the signal signal and the ECG signal, the second data library 411 obtains a heart image data and synchronizes the at least one heartbeat signal and the ECG signal, and simultaneously takes the closest feature point or characteristic parameter. The position of the heart map is taken as the object of capturing, and at least two feature points are extracted from the heart maps to obtain a time difference or a section slope of the at least two feature points. The manner in which the second database 411 is connected to the second signal receiving comparison module 41 is the same as that in the first embodiment, and details are not described herein again.

As described in the above paragraph, the second signal receiving comparison module 41 provided in this embodiment is connected to the second database 411 as a heartbeat data which is compared with the electrocardiogram and the cardiac ultrasound. After defining a plurality of feature points, a time difference or a section slope obtained by extracting at least two feature points from the cardiograms, the time difference is given by the at least two feature points having a specific physiological significance The correlation between the slope of the interval and the physiological state of the heart beat, and the established reference data base of the heart beat state. The cardiogram data of the second database 411 and the plurality of feature point obtaining methods defined therein are the same as those of the first embodiment, and thus are not described herein.

According to the above paragraph, the time difference obtained by the at least two feature points or the slope of the interval may be related to the physiological state of the heartbeat because the selected at least two feature points have a specific physiological significance, for example, when When at least two feature points are characteristic points of mitral valve opening and mitral valve closure, the time difference represented by the two characteristic points is the time required for mitral valve opening and closing. According to the above, the physiological significance represented by the time difference obtained by the at least two feature points may be the time elapsed from the time when the valve is opened to the maximum blood flow of the valve, the time when the blood flow of the pulse is maximum, the time when the valve is closed, or the valve is opened to the valve. The total time of closure may further include: total time of mitral valve opening to mitral valve closure, total time of tricuspid valve opening to tricuspid valve closure, total time of pulmonary valve opening to pulmonary valve closure, aortic valve The time from opening to the time of aortic valve closure, total time of tricuspid valve closure to pulmonary valve opening, total time of mitral valve closure to aortic valve opening, and mitral valve opening to maximum mitral valve flow Time, the time from the opening of the tricuspid valve to the maximal blood flow of the tricuspid valve, the elapsed time from the time when the aortic valve opens to the maximum flow of the aortic valve, the time when the pulmonary valve opens to the maximum flow of the pulmonary valve, The time of mitral valve venous flow is maximum until the mitral valve is closed, and the tricuspid valvular blood flow is maximum. Point to the tricuspid valve closure elapsed time, the maximum time of pulmonary valvular blood flow to the time of pulmonary valve closure or the time when the aortic valve blood flow is maximum to the aortic valve closure elapsed time; and the interval obtained by the at least two feature points The physiological significance expressed by the slope may be the slope of the increasing segment of the blood flow velocity or the slope of the descending segment of the blood flow velocity, which may further include: an increasing segment of the mitral valve blood flow velocity, and an increase in the velocity of the tricuspid valve blood flow. Segmental, pulmonary valve blood flow velocity increased, aortic valve blood flow velocity increased, mitral valve blood flow velocity decreased, tricuspid valve blood flow velocity decreased, pulmonary valve blood flow velocity decreased or Aortic valve blood flow velocity showed a decreasing segment.

The difference between the second database 411 of the second embodiment provided by the present invention and the prior art is further described below. As described in the first embodiment, the corresponding body surface area of the tricuspid valve is measured. The heart map is the most common type of heartbeat in the prior art. Although some of the heartbeat states have been defined, there are still many heartbeat feature points that cannot be peaked in the tricuspid heartbeat. And the manner of peaks and valleys is presented. Therefore, when selecting at least two feature points having physiological significance to observe the heartbeat state, the applicability is also quite limited. Conversely, the second aspect provided by the present invention In the embodiment, the cardiogram image obtained by using the position of the specific valve or the characteristic parameter is taken as the object of acquisition, and at least two feature points are obtained to obtain at least one time difference. Or a segment slope, so not only can more accurate measurement of the heart beat state, but also the peak buried in the tricuspid heartbeat signal The transition section or trough and crest overly densely in the section of the feature point, to improve observe beating heart state.

Please refer to FIG. 17 , which is a schematic diagram of the feature point extraction and comparison of the second embodiment provided by the present invention. As shown in the figure, the second data of the second embodiment provided by the present invention is shown. The library 411 can accurately observe the opening time of the pulmonary valve and the closing time of the pulmonary valve by the pulmonary heartbeat signal measured by the pulmonary valve surface area, and compare the same time in the tricuspid valve surface area. The measured tricuspid heartbeat signal can only be taken at the time of pulmonary valve opening, and the pulmonary valve heart image observed by the database provided by the present invention can clearly observe the time spent on pulmonary valve opening. It is possible to judge whether the physiological state of the pulmonary valve during the heartbeat is abnormal. Similarly, the database of the second embodiment provided by the present invention can accurately observe the opening time and the apex of the mitral valve by using the mitral valve heartbeat signal measured by the mitral valve surface region. At the time of closure of the valve, the tricuspid heartbeat signal measured at the same time in the surface region of the tricuspid valve is unable to extract any opening or closing time of the mitral valve, and thus the present invention provides The mitral valve heartbeat signal observed in the database can clearly observe the time taken for mitral valve sputum to determine whether the physiological state of the pulmonary valve during the heartbeat is abnormal, as an observation of the overall physiological state of the heart beat. in accordance with.

According to the above description, the second embodiment provided by the present invention can not only determine at least two feature points in a single cardiac image to determine the physiological state during the heartbeat, but also can simultaneously measure at least two heart attacks. At least one feature point is captured in each of the signal signals, and the physiological state of the interaction between the valve and the valve during the heartbeat is observed. Please refer to the thirteenth figure. Because of the direction and process of blood flow during the heartbeat, the valve movement in the left atrium should be [mitral valve opening à mitral valve closure à pulmonary valve opening à pulmonary valve closure à mitral valve opening] as a blood flow cycle, but because of the tricuspid heartbeat signal, only the corresponding feature points of the mitral valve and aortic valve opening and closing can be performed in the form of peak points and peaks and valleys. In the present case, it is impossible to obtain further information about the opening and closing of other valves during blood flow, so in this case, it is unable to effectively monitor the valve motion of the left atrial ventricle; and in the heartbeat physiology provided by the present invention In the measurement system, the measurement system can take the mitral valve heartbeat signal and the pulmonary valve heartbeat signal for the time point of the mitral valve closure and the time point of the pulmonary valve opening to observe the mitral valve closure. The time difference between the opening of the pulmonary valve (T _MC-PO ), or the time point at which the pulmonary valve is closed and the time at which the mitral valve is opened. To observe the time difference from pulmonary valve closure to mitral valve opening (T _PC-MO ), to further monitor the movement and blood flow status of specific valves as the basis for the overall physiological state of the heart beat.

In summary of the above embodiments, the time difference characteristic parameter provided by the present invention can be used as a basis for a plurality of cardiac pulsations as a whole physiological state, however, the monitoring is not limited thereto, and the total time of the mitral valve opening to the mitral valve closing is limited. Total time from valvular valve closure to tricuspid valve closure, total time from pulmonary valve opening to pulmonary valve closure, total aortic valve opening to aortic valve closure, total tricuspid valve closure to total pulmonary valve opening, mitral valve Total time from valve closure to aortic valve opening, elapsed time from mitral valve opening to maximum mitral valve venous flow, tricuspid valve opening to tricuspid valvular blood flow maximal elapsed time, aortic valve opening The time to the maximum flow of blood to the aortic valve, the time when the pulmonary valve is open to the maximum flow of the pulmonary valve, the time of the mitral valve, the time of mitral valve closure, the time of mitral valve closure, and the tricuspid valve The maximum flow point to the time of tricuspid valve closure, the maximum blood flow to the pulmonary valve, to the closure of the pulmonary valve Occasional blood aortic pulse lobe point to the maximum elapsed time to close the aortic valve, the present invention is based are provided to retrieve the time difference between the characteristic parameters can be monitored and the scope of the.

The following is a schematic diagram of the slope of the second database 411 of the second embodiment provided by the present invention. As shown in the figure, the second embodiment of the present invention provides The second database 411, in comparison with the tricuspid heartbeat signal acquisition method used in the prior art, can further extract the characteristic points of the blood flow of the valve through a maximum amount, such as a mitral valve. The maximum characteristic point of atrial contraction blood flow, the largest characteristic point of aortic valve blood flow or the maximum characteristic point of pulmonary valve blood flow can be obtained by using the database as a peak in at least one cardiac image signal. When the library reaches a peak value representing one of the largest characteristic points of the blood flow of the target valve, it also extracts a wave value before the peak of the wave or a wave value after the peak of the wave, and the peak value of the wave is compared with the former A segment between a wave trough is defined as an increasing segment of the target valve blood flow velocity, and a segment between the peak of the wave and the latter trough is defined as a descending segment of the target valve blood flow velocity, and then the target Valve blood The peak value of the peak value and the trough value of the increasing segment of the velocity is calculated as the increasing intensity of the blood flow velocity of the target valve. Conversely, the peak velocity of the peak and the trough value of the descending segment of the blood flow velocity of the target valve appears. It is then defined as the decreasing intensity of the target valve blood flow velocity. Therefore, the slope of the interval of the at least two feature points provided by the present invention is preferably an increasing segment of the mitral valve blood flow velocity, an increasing segment of the tricuspid valve blood flow velocity, and an increasing segment of the pulmonary valve blood flow velocity. The descending segment of the aortic valve blood flow velocity, the descending segment of the mitral valve blood flow velocity, the descending segment of the tricuspid valve blood flow velocity, the descending segment of the pulmonary valve blood flow velocity, or the descending segment of the aortic valve blood flow velocity. However, the invention is not limited thereto.

19 is a circuit block diagram of a heart beat physiological measurement system according to a preferred embodiment of the second embodiment of the present invention. As shown in the figure, the heart of the second embodiment provided by the present invention is shown. The pulsation physiological measurement system may further extend between the second signal receiving comparison module 41 and the inertial motion sensors 30 when the number of the inertial motion sensors 30 is at least two inertial motion sensors. Connecting a heartbeat signal processing module 412 for receiving and superimposing at least two acceleration measurement signals, processing the acceleration measurement signals to form a three-dimensional heartbeat signal, and transmitting the signals to the second signal reception comparison The module 41 performs signal comparison. The three-dimensional heartbeat signal is formed by superimposing the acceleration measurement signals, and can represent the X-axis of the heart valve position, the Y-axis of the heart valve position, the amplitude of the heart valve vibration, and the physiological state of the heart valve opening and closing time. It is a heart-strength map with four-dimensional meaning. The information of the X-axis, Y-axis, heart valve vibration amplitude and heart valve opening and closing time of the heart valve position provided by the three-dimensional heartbeat signal can accurately detect the vibration occurrence time and avoid the fluctuation of the excessive source and the earthquake. The amplitude attenuation affects the interpretation of the heart attack spectrum, and at the same time, it can better observe the open state of the heart valve during the heart beat, and use the graphical acceleration measurement signal to provide users with long-term and visual observations, and provide another user. In addition to observing the heartbeat, it can further replace the existing expensive and inconvenient cardiac imaging observation system, providing a more economical and convenient heartbeat physiological monitoring tool.

Please refer to the twentieth embodiment, which is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the second embodiment of the present invention. As shown in the figure, the second aspect of the present invention is provided. The heartbeat physiological measurement system of the embodiment may further be provided with a transmission unit 50 and a terminal device 60, wherein the transmission unit 50 and the terminal device 60 are the same as the first embodiment, and thus will not be further described herein.

Please refer to the twenty-first embodiment, which is a schematic structural diagram of a wearable device of the cardiac pulsation physiological measurement system according to the second embodiment of the present invention. As shown in the figure, the second signal receiving comparison module is configured. The 41 series is different from the first signal receiving comparison module 40 of the first embodiment, and the other hardware structures and information flow directions are the same as those of the first embodiment, and details are not described herein again.

Please refer to the twenty-second figure, which is a block diagram of the measuring device of the measuring device of the heartbeat physiology measuring system according to the third embodiment of the present invention. As shown in the figure, the measuring system provided in the embodiment A plurality of electrocardiographic measuring electrodes 20 and at least one inertial motion sensor 30 and a third signal receiving comparison module 42 are provided, wherein the electrocardiographic measuring electrodes 20 and the at least one inertial motion sensor 30 are disposed. The functions and functions are the same as those in the first embodiment, and thus will not be described again. The third signal receiving comparison module 42 of the embodiment is further provided with at least one microprocessor for processing the electrocardiogram signal and the at least one acceleration measuring signal, wherein the third signal receiving ratio is The step of integrating the at least one signal acceleration measurement signal into the at least one heartbeat signal and synchronizing the at least one heartbeat signal with the electrocardiogram signal is the same as the first embodiment, and details are not described herein again. . After the third signal receiving comparison module 42 synchronizes the at least one heartbeat signal and the electrocardiogram signal, an algorithm is used to select at least one heartbeat signal of the valve of the target feature point, and the ECG signal is used At least one starting point is generated on the at least one heartbeat signal, and then the at least one feature point is captured in a target time range according to the at least one starting point on the time axis of the at least one cardiogram signal.

According to the measurement system provided in the third embodiment of the present invention, the algorithm can be obtained by generating a signal on the aortic valve heartbeat signal by using the R wave peak on the electrocardiogram. a first starting point, and a peak point after a minimum valley point within 0.06 seconds after the first starting point, wherein the peak point is defined as a sidewall myocardial contraction maximum velocity feature point; or at the first starting point Then, a maximum peak point is obtained from 0.07 seconds to 0.1 seconds, and the maximum peak point is defined as the maximum characteristic point of the aortic valve blood flow; or the second peak of the R wave on the electrocardiogram is generated on the pulmonary valve heartbeat signal. Starting point, extracting a maximum peak point from 0.07 seconds to 0.1 seconds after the second starting point, wherein the maximum peak point is defined as a maximum velocity characteristic point of the middle myocardial contraction; or the R wave peak on the electrocardiogram is A second starting point is generated on the pulmonary valve heartbeat signal, and a second peak point between 0.085 seconds and 0.15 seconds after the second starting point is defined as the maximum characteristic point of pulmonary valve blood flow. Or with the R wave peak on the ECG A third starting point is generated on the signal signal of the mitral valve heartbeat, and the second peak point is calculated 0.02 seconds before the third starting point, and the peak point is defined as mitral atrial contraction blood The maximum characteristic point of the flow; or a third starting point on the mitral heartbeat signal of the R wave peak on the electrocardiogram, and one of the largest between 0.05 and 0.11 seconds after the third starting point a peak point, which is defined as a characteristic point of the wall myocardial contraction maximum velocity; or a fourth starting point is generated on the tricuspid heartbeat signal by the R wave peak on the electrocardiogram, and the fourth starting point The second peak point between 0.05 and 0.11 seconds after the start point, which is defined as the maximum speed characteristic point of the middle myocardial contraction, or any combination thereof, but the algorithm provided by the present invention should not limit.

Please refer to the twenty-third figure, which is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the third embodiment of the present invention. As shown in the figure, the present invention provides The heartbeat physiological measurement system of the second embodiment may further be provided with a transmission unit 50 and a terminal device 60, wherein the transmission unit 50 and the terminal device 60 are the same as the first embodiment, and thus will not be further described herein.

Please refer to FIG. 24 , which is a schematic structural diagram of a wearable device of a cardiac pulsation physiological measurement system according to a third embodiment of the present invention, as shown in the figure, except for a third signal receiving comparison module. The 42-series is different from the first signal receiving comparison module 40 of the first embodiment, and the other hardware structures and information flow directions are the same as those of the first embodiment, and details are not described herein again.

Please refer to the twenty-fifth figure, which is a block diagram of the measuring device of the measuring device of the heartbeat physiology measuring system according to the fourth embodiment of the present invention. As shown in the figure, the measuring system provided in the embodiment A plurality of electrocardiographic measuring electrodes 20 and at least one inertial motion sensor 30 and a fourth signal receiving comparison module 43 are provided, wherein the electrocardiographic measuring electrodes 20 and the at least one inertial motion sensor 30 are disposed. The functions and functions are the same as those in the first embodiment, and thus will not be described again. The fourth signal receiving and comparing module 43 provided in this embodiment is also provided with at least one microprocessor for performing processing of the electrocardiogram signal and at least one acceleration measuring signal, wherein the fourth signal receiving ratio is The step of integrating the at least one signal acceleration measurement signal into the at least one heartbeat signal and synchronizing the at least one heartbeat signal with the electrocardiogram signal is the same as the first embodiment, and details are not described herein again. . After the fourth signal receiving comparison module 43 synchronizes the at least one heartbeat signal and the electrocardiogram signal, an algorithm is used to select at least one heartbeat signal of the valve of the target feature point, and the ECG signal is used Generating at least one starting point on the at least one cardiogram signal, and then generating at least one corresponding point on the at least one cardiogram signal with the electrocardiogram signal, and performing the at least one feature between the at least one starting point and the at least one corresponding point Click to pick.

According to the measurement system provided in the fourth embodiment of the present invention, the algorithm can be obtained by generating a P-wave peak on the electrocardiogram on the aortic valve heartbeat signal. a corresponding point, a peak of the R wave on the electrocardiogram is generated on the aortic valve heartbeat signal to generate a first starting point, and a maximum peak point is taken between the first starting point and the first corresponding point, The maximum peak point is defined as the maximum characteristic point of the mitral atrial contraction blood flow, or a second corresponding point is generated on the aortic valve heartbeat signal by the T wave peak on the electrocardiogram, 0.1 second after the first starting point A maximum peak point is obtained to the second corresponding point, and the maximum peak point is defined as the maximum characteristic point of the pulmonary valve blood flow, or any combination thereof, but the algorithm provided by the present invention should not be limited thereto.

Referring to FIG. 26, it is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the fourth embodiment of the present invention. As shown in the figure, the present invention provides The heartbeat physiological measurement system of the second embodiment may further be provided with a transmission unit 50 and a terminal device 60, wherein the transmission unit 50 and the terminal device 60 are the same as the first embodiment, and thus will not be further described herein.

Please refer to the twenty-seventh figure, which is a schematic structural diagram of the wearable device of the cardiac pulsation physiological measurement system according to the fourth embodiment of the present invention, as shown in the figure, except for the fourth signal receiving comparison module. The 43 series is different from the first signal receiving comparison module 40 of the first embodiment, and the other hardware structures and information flow directions are the same as those of the first embodiment, and details are not described herein again.

Please refer to the twenty-eighth, which is a circuit block diagram of the measuring device of the cardiac pulsation physiological measuring system according to the fifth embodiment of the present invention. As shown in the figure, the measuring system provided in the embodiment A plurality of electrocardiographic measuring electrodes 20 and at least one inertial motion sensor 30 and a fifth signal receiving comparison module 44, wherein the electrocardiographic measuring electrodes 20 and the at least one inertial motion sensor 30 are disposed The functions and functions are the same as those in the first embodiment, and thus will not be described again. The fifth signal receiving comparison module 44 of the embodiment is further provided with at least one microprocessor for performing processing of the electrocardiogram signal and at least one acceleration measuring signal, wherein the fifth signal receiving ratio is The step of integrating the at least one signal acceleration measurement signal into the at least one heartbeat signal and synchronizing the at least one heartbeat signal with the electrocardiogram signal is the same as the first embodiment, and details are not described herein again. . After the fifth signal receiving comparison module 44 synchronizes the at least one heartbeat signal and the electrocardiogram signal, an algorithm is used to select at least one heartbeat signal of the valve of the target feature point, and the ECG signal is used At least one starting point is generated on the at least one heartbeat signal, and then the signal receiving and comparing module obtains at least two feature points on the at least one heartbeat signal according to the starting point by an algorithm to obtain the at least two features. One time difference or one interval slope.

According to the measurement system provided in the fifth embodiment of the present invention, the algorithm may be configured to capture the maximum characteristic of the mitral atrial constricted blood flow on the at least one cardiac image signal. Point and one of the trough points before the feature point, calculate the slope of the two-point line as an increasing rate of mitral valve blood flow velocity, or draw the mitral atrial systolic blood flow maximally on the at least one cardiac image signal The feature point and one of the trough points after the feature point, calculate the slope of the two-point line, appear as a deceleration rate of the mitral valve blood flow velocity, or draw the aortic valve atrial contraction blood flow on the at least one cardiac image signal The maximum feature point and one of the trough points before the feature point, calculate the slope of the two-point line as an increasing rate of aortic valve blood flow velocity, or draw the aortic valve atrial contraction blood on the at least one cardiac image signal The maximum characteristic point of the flow and one of the trough points after the characteristic point, calculate the slope of the two-point connection, as a deceleration rate of the aortic valve blood flow velocity, or draw the pulmonary valve atrium on the at least one cardiac image signal The maximum characteristic point of the contracted blood flow and one of the trough points before the characteristic point, the slope of the two-point connection is calculated as an increasing rate of the pulmonary valve blood flow velocity, or the pulmonary valve atrial contraction is captured on the at least one cardiac image signal The maximum characteristic point of the blood flow and one of the trough points after the characteristic point, the slope of the two-point connection is calculated as the deceleration rate of the pulmonary valve blood flow velocity, or any combination thereof, but the algorithm provided by the present invention should not This is limited.

Please refer to the twenty-ninth aspect, which is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the fifth embodiment of the present invention. As shown in the figure, the present invention provides The heartbeat physiological measurement system of the second embodiment may further be provided with a transmission unit 50 and a terminal device 60, wherein the transmission unit 50 and the terminal device 60 are the same as the first embodiment, and thus will not be further described herein.

Please refer to FIG. 30 , which is a schematic structural diagram of a wearable device of a heart beat physiological measurement system according to a fifth embodiment of the present invention. As shown in the figure, the structure is divided into a fifth signal receiving comparison module 44 . The same as the first signal receiving comparison module 40 of the first embodiment, the other hardware structures and information flow directions are the same as those of the first embodiment, and details are not described herein again.

In summary, the present invention provides a heartbeat physiology measurement system and method thereof, which utilizes a heartbeat state database established by using a plurality of feature points obtained by comparing a heartbeat map, an electrocardiogram, and a cardiac ultrasound. It is possible to obtain the accuracy and fineness of the measurement of the heart ultrasound instrument only when the electrocardiogram and the heart rate map are measured. At the same time, the cardiogram is performed by at least one integrated table area corresponding to the position of the four heart valves. Acceleration signal measurement, matching with feature points is based on the design of the heartbeat map closest to the feature point or the location of the feature parameters, which can overcome the prior art tricuspid heart rate map is the most common The type of heartbeat is used, but there are still many cardiac pulsation feature points that cannot be presented in the tricuspid heartbeat in the form of peak points and peaks and valleys, due to other cardiac spectroscopy such as mitral valve The heartbeat map, the aortic valve heart map, and the pulmonary valve heart map are suitable for the feature points, which can compare more and more accurate heart beats than the existing heart map measurements. The invention can accurately monitor the movement state of the specific valve and the blood flow situation, and obtain more accurate information about the physiological state of the heart beat. In addition, the present invention provides a measurement system for the heart beat physiology by providing a transmission unit and a The terminal device can use textual, digitized or graphical image presentation to enable users to more quickly and accurately understand the results obtained by the measurement system, and can further perform data comparison, massive analysis, data storage or The data is uploaded to the cloud system and other data processing, so that the measurement system can achieve more diverse functions, and even more, it can be obtained at home or regional hospitals with high hardware requirements for high precision and high. Accurate heart beat physiological monitoring to improve the convenience of the cardiac function-assisted judgment system to achieve medical popularization; finally, by combining the heart beat physiological measurement system provided by the present invention with the wearable device, it is possible to achieve the time, Local, follow-up and portable physiological monitoring targets, playing at home care for abnormal warning and efficacy evaluation When the important role. Accordingly, the present invention provides a novel cardiac pulsation physiological measurement system and measurement method, which overcomes the long-standing bottleneck in the measurement of cardiac pulsation physiological state in the related art field, and indeed has the patent requirements for patent application.

The above is only the preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and the variations, modifications, and modifications of the shapes, structures, features, and spirits described in the claims of the present invention. All should be included in the scope of the patent application of the present invention.

10‧‧‧ Subjects

11‧‧‧Aortic valve surface area

12‧‧‧ mitral valve surface area

13‧‧‧Pulmonary valve surface area

14‧‧‧ Tricuspid valve surface area

20‧‧‧ECG measuring electrode

30‧‧‧Inertial Motion Sensor

40‧‧‧First signal receiving comparison module

41‧‧‧Second signal receiving comparison module

42‧‧‧Third signal receiving comparison module

43‧‧‧fourth signal receiving comparison module

44‧‧‧Fifth signal receiving comparison module

401‧‧‧First database

411‧‧‧Second database

412‧‧‧Heart vibration signal processing module

50‧‧‧Transportation unit

60‧‧‧ Terminal devices

70‧‧‧First Wear Department

80‧‧‧Second Wear Department

90‧‧‧ Connection unit

1 is a schematic structural view of a measuring device of a cardiac pulsation physiological measuring system according to a first embodiment of the present invention; FIG. 2 is a cardiac physiology measuring system according to a first embodiment of the present invention; Circuit block diagram; FIG. 3 to FIG. 11 : It is a preferred embodiment of the method for obtaining feature points of the database provided by the present invention, and the characteristic point comparison diagrams of the cardiogram, electrocardiogram and cardiac ultrasound map are shown. Fig. 12A and Fig. 12B are schematic diagrams showing the results of measurement of four heart valve heart maps and their feature points provided by the present invention; Figs. 13A and 13B: Fig. 13 is the present invention An electrocardiogram and a cardiogram comparison chart of a heart beat physiological measurement system for normal people and heart disease measured by the mitral valve; FIG. 14 is another preferred embodiment of the first embodiment of the present invention. A circuit block diagram of a cardiac pulsation physiological measurement system of an embodiment; FIG. 15 is a schematic structural view of a wearable device of a cardiac pulsation physiological measurement system according to a first embodiment of the present invention; Second embodiment of the invention Block diagram of the measuring device of the measuring system of the heart beat physiology; FIG. 17 is a schematic diagram of the feature point extraction and comparison of the database according to the second embodiment of the present invention; FIG. 18 is a view of the present invention FIG. 19 is a circuit block diagram of a heartbeat physiological measurement system according to another preferred embodiment of the second embodiment of the present invention. FIG. FIG. 20 is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the second embodiment of the present invention; FIG. 21 is a second embodiment of the present invention; FIG. 22 is a schematic circuit diagram of a heartbeat physiological measurement system according to a third embodiment of the present invention; FIG. 23 is a schematic diagram of a circuit of the present invention. A circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the third embodiment; FIG. 24 is a wearable device of the cardiac pulsation physiological measurement system according to the third embodiment of the present invention; Figure 25 is a circuit block diagram of a heart beat physiological measurement system according to a fourth embodiment of the present invention; Figure 26 is another preferred embodiment of the fourth embodiment of the present invention. A block diagram of a circuit diagram of a heart beat physiological measurement system; FIG. 27 is a schematic structural view of a wearable device of a heart beat physiological measurement system according to a fourth embodiment of the present invention; FIG. 28 is a view of the present invention FIG. 29 is a circuit block diagram of a cardiac pulsation physiological measurement system according to another preferred embodiment of the fifth embodiment of the present invention; FIG. And FIG. 30 is a schematic structural view of a wearable device of the heartbeat physiological measurement system according to the fifth embodiment of the present invention.

10‧‧‧ Subjects

11‧‧‧Aortic valve surface area

12‧‧‧ mitral valve surface area

13‧‧‧Pulmonary valve surface area

14‧‧‧ Tricuspid valve surface area

20‧‧‧ECG measuring electrode

30‧‧‧Inertial Motion Sensor

40‧‧‧Signal receiving comparison module

Claims (55)

A heartbeat physiology measuring system, the system comprising: a plurality of electrocardiographic measuring electrodes attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal; at least one inertial motion sensor And the first signal receiving comparison module is configured to synchronously receive the at least one integrated measuring area corresponding to the position of the heart valve to be measured. The electrocardiogram signal and the at least one acceleration measurement signal cause the at least one acceleration measurement signal to form at least one heartbeat signal, and use the electrocardiogram signal to generate a starting point on the at least one heartbeat signal, by using the starting point Comparing a first database to at least one feature point on the at least one heartbeat signal to form a first comparison result, wherein the first database uses a heartbeat signal, an electrocardiogram, and a cardiac ultrasound ratio Established for the plurality of feature points obtained. The system of measuring a cardiac pulsation physiology according to the first aspect of the invention, further comprising: a transmission unit connected to the first signal comparison module, receiving the first comparison result, the electrocardiogram signal, and The at least one heartbeat signal and the transmission of a data; and a terminal device connected to the transmission unit, receiving the data transmitted by the transmission unit, and performing rendering or advanced processing of the data. The cardiac pulsation physiology measuring system according to claim 1, wherein the at least one integrated table region comprises a second rib of the left sternal border and extends to the right across the sternum stem to the second and third intercostal aorta of the right sternal border. The valve body area. The cardiac pulsation physiology measuring system according to claim 1, wherein the at least one integrated surface region comprises a mitral valve surface region in which a fifth intercostal space of the right sternum extends to the posterior tibial line. The heartbeat physiology measuring system according to the first aspect of the invention, wherein the at least one integrated table region comprises a second intercostal space of the left sternal border, extending upward to the first intercostal space, the left subclavian region, and extending downward to the sternum The area of the pulmonary valve body at the third intercostal space on the left edge. The cardiac pulsation physiology measuring system according to claim 1, wherein the at least one integrated table region comprises a tricuspid valve surface region extending to the right of the fourth and fifth intercostals of the right sternal border. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a first inertial motion sensor to one of the corresponding heart valves In the aortic valve surface region, the inertial motion sensor generates an aortic heartbeat signal, and the aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the second right edge of the sternum, Between the three ribs; a first cardiac inductance measuring module is configured to generate a first electrocardiogram signal on the measurement path of the limb conductor; and extracting one of the P peak points and the R peak point on the first electrocardiogram signal, and The P peak point and the R peak point respectively correspond to the aortic heartbeat signal generating a first corresponding point and a second corresponding point; and extracting one from the first corresponding point to the second corresponding point At the peak point, after obtaining a cardiac ultrasound map and confirming the alignment, the maximum peak point represents the maximum characteristic point of a mitral atrial contraction blood flow. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a first inertial motion sensor to one of the corresponding heart valves In the aortic valve surface region, the inertial motion sensor generates an aortic heartbeat signal, and the aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the second right edge of the sternum, Between the three ribs; a first cardiac inductance measuring module is configured to generate a first electrocardiogram signal on a limb conductor measuring area; Extracting one of the R peak points on the first electrocardiogram signal, and causing the R peak point to generate a second corresponding point corresponding to the aortic heartbeat signal; and sequentially extracting 0.06 seconds from the second corresponding point One of the minimum valley points and one of the peak points after the minimum valley point, after obtaining a cardiac ultrasound map and confirming the alignment, the peak point indicates a side wall myocardial contraction maximum velocity feature point. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a first inertial motion sensor to one of the corresponding heart valves In the aortic valve surface region, the inertial motion sensor generates an aortic heartbeat signal, and the aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the second right edge of the sternum, Between the three ribs; a first cardiac inductance measuring module is configured to generate a first electrocardiogram signal on a limb conductor measuring area; and extracting one of the R peak points on the first electrocardiogram signal, and the R peak point corresponds to The aortic heartbeat signal generates a second corresponding point; and one of the maximum peak points from 0.07 seconds to 0.1 seconds after the second corresponding point is obtained, and after obtaining a cardiac ultrasound map and confirming the comparison, The maximum peak point represents the largest characteristic point of aortic valve blood flow. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a first inertial motion sensor to one of the corresponding heart valves In the aortic valve surface region, the inertial motion sensor generates an aortic heartbeat signal, and the aortic valve surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the second right edge of the sternum, Between the three ribs; a first cardiac inductance measuring module is configured to generate a first electrocardiogram signal on a limb conductor measuring area; Extracting one R peak point and one T wave peak point on the first electrocardiogram signal, so that the R peak point and the T wave peak point respectively generate a second corresponding point and a third corresponding to the aortic heartbeat signal a point; and extracting from the second corresponding point to a maximum peak point of the third corresponding point, after obtaining a cardiac ultrasound map and confirming the comparison, the maximum peak point represents a pulmonary valve blood The largest feature point of the stream. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a second inertial motion sensor to one of the corresponding heart valves In the pulmonary valve surface region, the inertial motion sensor generates a pulmonary artery heartbeat signal, and the pulmonary valve body surface region includes a second rib of the left sternal border and extends upward to the first intercostal space, the left subclavian region, and extends downward. a third intercostal space to the left edge of the sternum; a first cardiac inductance measuring module is configured to generate a first electrocardiogram signal on a limb conductor measuring area; and extracting one of the R peak points on the first electrocardiogram signal, and The R peak point corresponds to the pulmonary artery heartbeat signal to generate a fourth corresponding point; and the maximum peak point from 0.07 seconds to 0.1 second after the fourth corresponding point is obtained, and a cardiac ultrasound map is obtained and compared After confirmation, the maximum peak point represents a maximum velocity characteristic point of myocardial contraction. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a second inertial motion sensor to one of the corresponding heart valves In the pulmonary valve surface region, the inertial motion sensor generates a pulmonary artery heartbeat signal, and the pulmonary valve body surface region includes a second rib of the left sternal border and extends upward to the first intercostal space, the left subclavian region, and extends downward. a third intercostal space to the left edge of the sternum; a first cardiac inductance measuring module is provided to generate a first electrocardiogram signal on the measurement area of the limb conductor; Extracting one of the R peak points on the first electrocardiogram signal, and causing the R peak point to generate a fourth corresponding point corresponding to the pulmonary artery heartbeat signal; and extracting 0.085 seconds to 0.15 seconds after the fourth corresponding point The second peak point between the two, after obtaining a cardiac ultrasound map and confirming the alignment, the peak point represents the maximum characteristic point of a pulmonary valve blood flow. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a third inertial motion sensor to one of the corresponding heart valves In the mitral valve surface region, the inertial motion sensor generates a mitral valve heartbeat signal, and the mitral valve surface region includes a fifth rib of the right sternal border extending to the posterior tibial line; and a first cardiac inductance measurement is set. The module generates a first electrocardiogram signal on the measurement path of the limb conductor; extracts an R peak point on the first electrocardiogram signal, and causes the R peak point to correspond to the mitral heartbeat signal to generate a signal a fifth corresponding point; and a second peak point before 0.02 seconds before the fifth corresponding point, after obtaining a cardiac ultrasound map and confirming the alignment, the peak point represents a mitral atrial contraction blood The largest feature point of the stream. The measuring system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the obtaining of the characteristic points in the first database is: setting a third inertial motion sensor to one of the corresponding heart valves In the mitral valve surface region, the inertial motion sensor generates a two-point heartbeat signal, the mitral valve surface region includes a fifth rib of the right sternal border extending to the posterior iliac line; and a first cardiac inductor is provided The group generates a first electrocardiogram signal on the measurement area of the limb conductor; extracts an R peak point on the first electrocardiogram signal, and causes the R peak point to correspond to the mitral valve heartbeat signal to generate a first Five corresponding points; Taking one of the maximum peak points from 0.05 seconds to 0.11 seconds after the fourth corresponding point, after obtaining a cardiac ultrasound map and confirming the alignment, the maximum peak point represents a side wall myocardial contraction maximum velocity feature point. The system for measuring cardiac pulsation physiology according to claim 1, wherein the method for obtaining the feature points in the first database is: setting a fourth inertial motion sensor to one of the corresponding heart valves. a tricuspid valve surface region, the inertial motion sensor generates a tricuspid heartbeat signal, the tricuspid valve surface region includes a fourth and fifth intercostal space extending to the right of the right sternal border; and a first cardiac inductance measurement is set The module generates a first electrocardiogram signal on the measurement path of the limb conductor; extracts an R peak point on the first electrocardiogram signal, and causes the R peak point corresponding to the tricuspid heartbeat signal to generate a signal a sixth corresponding point; and a second peak point within 0.05 seconds to 0.11 seconds after the sixth corresponding point is obtained, and after obtaining a cardiac ultrasound map and confirming the alignment, the peak point represents a middle myocardial Shrink the maximum speed feature point. The cardiac pulsation physiology measuring system according to the first aspect of the invention, wherein the electrocardiographic measuring electrodes and the inertial motion sensors are further disposed on an inner side of the close-fitting clothing, and the inertial motion sensors are the same The measurement is performed on the at least one integrated surface area corresponding to the position of the heart valve. The measurement system of the cardiac pulsation physiology according to the first aspect of the invention, wherein the at least one feature point is obtained by selecting a time from the starting point on a time axis of the at least one heartbeat signal. Obtaining the at least one feature point. The method for measuring a cardiac pulsation physiology according to the first aspect of the invention, wherein the first database is configured to capture at least one feature point on the at least one cardiac image signal to at least one of the database The database heartbeat signal is superimposed on the at least one heartbeat signal, and the corresponding position of the at least one cardiogram signal is compared with the plurality of database feature points of the first database to obtain the at least one feature. point. A heartbeat physiology measuring system, the system comprising: a plurality of electrocardiographic measuring electrodes attached to a plurality of measuring portions of a subject to sense and generate an electrocardiogram signal; at least one inertial motion sensor The system is disposed at least one integrated measurement area corresponding to the position of the heart to be measured for sensing at least one acceleration measurement signal; and a second signal receiving comparison module synchronously receiving the electrocardiogram signal and the at least one The acceleration measurement signal causes the at least one acceleration measurement signal to form at least one heartbeat signal, and uses the electrocardiogram signal to generate a starting point on the at least one heartbeat signal, wherein the starting point is compared with a second data The library obtains at least two feature points on the at least one heartbeat signal, and obtains a time difference or a range slope of the at least two feature points to form a second comparison result, wherein the second database uses a heartbeat map The characteristic points obtained by the signal, the electrocardiogram and the cardiac ultrasound comparison, the time difference of the feature points obtained by at least two feature points and the slope of the interval, the established heart beat State database. The heart beat physiological measurement system according to claim 19, wherein when the number of the at least one inertial motion sensor is a two inertial motion sensor, the system further comprises a heartbeat signal processing module. The group is connected between the two inertial motion sensors and the second signal receiving comparison module, and receives the two acceleration measurement signals generated by the two inertial motion sensors, and the two acceleration measurement signals are After being superimposed to generate a three-dimensional heartbeat signal, the signal is transmitted to the second signal receiving comparison module. The heart beat physiological measurement system of claim 19, further comprising: a transmission unit coupled to the second signal receiving comparison module for receiving the second comparison result, the electrocardiogram The signal and the at least one heartbeat signal transmit a data; and a terminal device connected to the transmission unit, receiving the data transmitted by the transmission unit, and performing rendering or advanced processing of the data. The heart beat physiological measurement system according to claim 19, wherein the at least one The body surface region includes a second rib of the left sternal border extending to the right across the sternum stem to the aortic valve surface region between the second and third intercostals of the right sternal border. The cardiac pulsation physiology measuring system according to claim 19, wherein the at least one integrated table region comprises a mitral valve surface region in which a fifth intercostal space of the right sternum extends to the posterior tibial line. The cardiac pulsation physiology measuring system according to claim 19, wherein the at least one integrated table region comprises a second rib of the left sternal border and extends upward to the first intercostal space, the left subclavian region and extends downward to the sternum The area of the pulmonary valve body at the third intercostal space on the left edge. The cardiac pulsation physiology measuring system according to claim 19, wherein the at least one integrated table region comprises a tricuspid valve surface region extending to the right of the fourth and fifth intercostals of the right sternal border. The cardiac pulsation physiology measuring system of claim 19, wherein the electrocardiographic measuring electrodes and the inertial motion sensors are further disposed on an inner side of the close-fitting clothing, and the inertial motion sensors The measurement is also performed on the at least one integrated surface region corresponding to the position of the heart valve. The system for measuring cardiac pulsation physiology according to claim 19, wherein the time difference of the at least two characteristic points is a time elapsed from when the valve is opened to the maximum blood flow of the valve, and when the blood flow of the pulse is maximum, the valve is closed. Time or valve opening to the total time the valve is closed. The heart beat physiological measurement system according to claim 19, wherein the slope of the interval of the at least two feature points is a slope of an increasing segment of the blood flow velocity or a slope of a decreasing segment of the blood flow velocity. The cardiac pulsation physiology measuring system according to claim 19, wherein the time difference of the at least two feature points is a total time when the mitral valve is opened to the mitral valve closing time, and the tricuspid valve is opened to the tricuspid valve. Total valve closure time, total time from pulmonary valve opening to pulmonary valve closure, total aortic valve opening to aortic valve closure, total tricuspid valve closure to total pulmonary valve opening, mitral valve closure to aortic valve opening Time, mitral valve opening to the mitral valve The elapsed time from the time when the tricuspid valve opens to the maximum flow of the tricuspid valve, the time when the aortic valve opens to the maximum flow of the aortic valve, the time when the pulmonary valve opens to the maximum flow of the pulmonary valve, The time of mitral valve venous flow to the time of mitral valve closure, the maximum time of tricuspid valvular blood flow to the time of tricuspid valve closure, the maximum time of pulmonary valvular blood flow to the time of pulmonary valve closure or The time from the maximum flow of the aortic valve to the aortic valve closure time. The measurement system of cardiac pulsation physiology according to claim 19, wherein the slope of the interval of the at least two characteristic points is an increasing segment of the mitral valve blood flow velocity, an increasing segment of the tricuspid valve blood flow velocity, and a pulmonary artery The valve blood flow velocity increases, the aortic valve blood flow velocity increases, the mitral valve blood flow velocity decreases, the tricuspid valve blood flow velocity decreases, the pulmonary valve blood flow velocity decreases, or the aortic valve The blood flow velocity appears to decrease. A heart beat physiological measurement system, the system comprising: a plurality of electrocardiographic measurement electrodes attached to a plurality of measurement sites on a subject to sense and generate an electrocardiogram; at least one inertial motion sensor, The system is disposed at at least one integrated measurement area corresponding to the position of the heart valve to be measured, and is configured to sense at least one acceleration measurement signal of the vibration of the body surface region; and a third signal receiving comparison module that synchronously receives the electrocardiogram The signal and the at least one acceleration measurement signal cause the at least one acceleration measurement signal to form at least one heartbeat signal, and use the ECG signal to generate at least one starting point on the at least one heartbeat signal, and the third signal is received The comparison module acquires at least one feature point on the at least one heartbeat signal according to the at least one starting point to form a third comparison result, wherein the algorithm uses the at least one heartbeat signal time The at least one feature point is captured on the axis based on the starting point. The system for measuring cardiac pulsation physiology as described in claim 31, the system further comprising: a transmission unit connected to the third signal receiving comparison module, receiving the third comparison result, the electrocardiogram signal and the at least one heartbeat signal, and transmitting a data; and a terminal device, The transmission unit is connected, receives the data transmitted by the transmission unit, and performs presentation or advanced processing of the data. The cardiac pulsation physiology measuring system according to claim 31, wherein the at least one integrated surface region comprises a second rib of the left sternal border and extends to the right across the sternum stem to the second and third intercostal aorta of the right sternal border. The valve body area. The cardiac pulsation physiology measuring system according to claim 31, wherein the at least one integrated table region comprises a mitral valve surface region in which a fifth intercostal space of the right sternum extends to the posterior tibial line. The cardiac pulsation physiology measuring system according to claim 31, wherein the at least one integrated table region comprises a second rib of the left sternal border and extends upward to the first intercostal space, the left subclavian region and extends downward to the sternum. The area of the pulmonary valve body at the third intercostal space on the left edge. The cardiac pulsation physiology measuring system according to claim 31, wherein the at least one integrated table region comprises a tricuspid valve surface region extending to the right of the fourth and fifth intercostals of the right sternal border. The measurement system of cardiac pulsation physiology according to claim 31, wherein the algorithm comprises: generating a first starting point on the aortic valve heartbeat signal by using the R wave peak on the electrocardiogram; A peak point is taken after a minimum valley point within 0.06 seconds after the first starting point, and the peak point is defined as a characteristic point of the wall myocardial contraction maximum velocity; and is taken within 0.07 seconds to 0.1 seconds after the first starting point a maximum peak point at which the maximum characteristic point of the aortic valve blood flow is defined; and a peak of the R wave on the electrocardiogram produces a second starting point on the pulmonary heartbeat signal, at the second start A maximum peak point is taken from 0.07 seconds to 0.1 seconds after the point, and the maximum peak point is defined as the maximum velocity characteristic point of the middle myocardial contraction; The second peak point between 0.085 seconds and 0.15 seconds after the second starting point, the peak point is defined as the maximum characteristic point of pulmonary valve blood flow; the R wave peak on the electrocardiogram is in a mitral heart attack A third starting point is generated on the signal signal, and the second peak point is calculated forward 0.02 seconds before the third starting point, and the peak point is defined as the maximum characteristic point of the mitral atrial contraction blood flow; One of the maximum peak points between 0.05 and 0.11 seconds after the third starting point, which is defined as the maximum speed characteristic point of the wall myocardial contraction; the R wave peak on the electrocardiogram is on a tricuspid heartbeat signal Generating a fourth starting point and a second peak point between 0.05 and 0.11 seconds after the fourth starting point, wherein the peak point is defined as a maximum speed characteristic point of the middle myocardial contraction; or one of the above Or any combination thereof. The cardiac pulsation physiology measuring system of claim 31, wherein the electrocardiographic measuring electrodes and the inertial motion sensors are further disposed on an inner side of a close-fitting clothing, and the inertial motion sensors The measurement is also performed on the at least one integrated surface region corresponding to the position of the heart valve. A heartbeat physiology measuring system, the system comprising: a plurality of electrocardiographic measuring electrodes attached to a measuring part of the subject to sense and generate an electrocardiogram signal; at least one inertial motion sensor, the system The at least one integrated surface area corresponding to the position of the heart valve is configured to sense at least one acceleration measurement signal of the vibration of the surface area; and the fourth signal receiving comparison module synchronously receives the electrocardiogram signal and the at least one The acceleration measurement signal is configured to form at least one heartbeat signal by the at least one acceleration measurement signal, and generate at least one starting point on the at least one heartbeat signal by using the electrocardiogram signal, and the fourth signal receiving the comparison module An algorithm extracts at least one feature point on the at least one heartbeat signal according to the at least one starting point, wherein the algorithm uses the electrocardiogram based on the starting point on the time axis of the at least one heartbeat signal The signal generates at least one corresponding point on the at least one heartbeat signal, at least A capture of the at least one feature point is performed between a starting point and the at least one corresponding point to form a fourth alignment result. The system for measuring cardiac pulsation physiology according to claim 39, further comprising: a transmission unit connected to the fourth signal receiving comparison module, receiving the fourth comparison result, and the electrocardiogram signal And the at least one heartbeat signal, and transmitting a data; and a terminal device connected to the transmission unit, receiving the data transmitted by the transmission unit, and performing rendering or advanced processing of the data. The cardiac pulsation physiology measuring system according to claim 39, wherein the at least one integrated surface region comprises a second rib of the left sternal border and extends to the right across the sternum stem to the second and third intercostal aorta of the right sternal border. The valve body area. The cardiac pulsation physiology measuring system of claim 39, wherein the at least one integrated table region comprises a mitral valve surface region extending from the fifth intercostal space of the right sternum to the posterior tibial line. The cardiac pulsation physiology measuring system according to claim 39, wherein the at least one integrated table region comprises a second rib of the left sternal border and extends upward to the first intercostal space, the left subclavian region and extends downward to the sternum The area of the pulmonary valve body at the third intercostal space on the left edge. The cardiac pulsation physiology measuring system according to claim 39, wherein the at least one integrated table region comprises a tricuspid valve surface region extending to the right from the fourth and fifth intercostals of the right sternal border. The system for measuring cardiac pulsation physiology according to claim 39, wherein the algorithm comprises: generating a first corresponding point on the electrocardiogram on the electrocardiogram by generating a first corresponding point on the signal of the P wave on the electrocardiogram The R wave peak generates a first starting point on the aortic valve heartbeat signal, and a maximum peak point is drawn between the first starting point and the first corresponding point, and the maximum peak point is defined as a cusp The maximum characteristic point of the atrial contraction of blood flow; or Generating a second corresponding point on the aortic valve heartbeat signal on the electrocardiogram, and extracting a maximum peak point from the first starting point 0.1 second to the second corresponding point to the maximum peak point Defined as the largest characteristic point of pulmonary valve blood flow; one of the above or any combination thereof. A heartbeat physiology measuring system, the system comprising: a plurality of electrocardiographic measuring electrodes attached to a measuring part of the subject to sense and generate an electrocardiogram signal; at least one inertial motion sensor, the system The at least one integrated area of the corresponding heart valve position is configured to sense at least one acceleration measurement signal of the vibration of the body surface area; and the fifth signal receiving comparison module receives the electrocardiogram signal and the at least one The acceleration measurement signal, the at least one acceleration measurement signal forms at least one heartbeat signal, and generates at least one starting point on the at least one heartbeat signal by using the electrocardiogram signal, and the fifth signal receiving comparison module performs a calculation The method obtains at least two feature points on the at least one heartbeat signal according to the starting point, and obtains a time difference or a section slope of the at least two feature points to form a fifth comparison result. The inertial motion sensor inertial motion sensor inertial motion sensor, such as the cardiac pulsation physiological measurement system of claim 46, further comprising: a transmission unit that receives the comparison mode with the fifth signal a group connection, receiving the fifth comparison result, the electrocardiogram signal and the at least one heartbeat signal, and transmitting a data; and a terminal device connected to the transmission unit for receiving the transmission by the transmission unit The information and the presentation or advanced processing of the information. The cardiac pulsation physiology measuring system according to claim 46, wherein the at least one integrated table region comprises a second rib of the left sternal border and extends to the right across the sternum stem to the second and third intercostal aorta of the right sternal border. The valve body area. The heartbeat physiology measuring system of claim 46, wherein the at least one integrated table region comprises a mitral valve surface region extending from the fifth intercostal space of the right sternal border to the posterior tibial line. area. The heartbeat physiology measuring system of claim 46, wherein the at least one integrated table region comprises a second intercostal space of the left sternal border, extending upward to the first intercostal space, the left subclavian region, and extending downward to the sternum The area of the pulmonary valve body at the third intercostal space on the left edge. The heartbeat physiology measuring system of claim 46, wherein the at least one integrated table region comprises a tricuspid valve surface region extending to the right of the fourth and fifth intercostals of the right sternal border. The cardiac pulsation physiology measuring system of claim 46, wherein the electrocardiographic measuring electrodes and the inertial motion sensors are further disposed on an inner side of a close-fitting garment, and the inertial motion sensors The measurement is also performed on the at least one integrated surface region corresponding to the position of the heart valve. The heartbeat physiology measuring system according to claim 46, wherein the characteristic points are selected from a maximum characteristic point of a mitral atrial contraction blood flow, a side wall myocardial contraction maximum velocity characteristic point, and an aorta. One of the maximum characteristic points of the valvular blood flow, one of the maximum speed characteristic points of myocardial contraction, one of the largest characteristic points of the pulmonary valve blood flow, or any combination thereof. The system for measuring cardiac pulsation physiology according to claim 46, wherein the slope of the interval of the at least two feature points is a slope of an increasing segment of the blood flow velocity or a slope of a decreasing segment of the blood flow velocity. The system for measuring cardiac pulsation physiology according to claim 46, wherein the algorithm comprises: capturing a maximum characteristic point of the mitral atrial constricted blood flow on the at least one cardiac image signal and before the characteristic point One of the trough points, the slope of the two-point line is calculated as an increasing rate of the mitral valve blood flow velocity; the maximum characteristic point of the mitral atrial systolic blood flow is captured on the at least one cardiac image signal and the characteristic point is One trough point, calculate the slope of the two-point line, as the deceleration rate of the mitral valve blood flow velocity; Obtaining a maximum characteristic point of the aortic valve atrial constricted blood flow and a trough point before the characteristic point on the at least one cardiac image signal, and calculating a slope of the two-point connection as an increasing rate of aortic valve blood flow velocity; Obtaining a maximum characteristic point of the aortic valve atrial constricted blood flow and a trough point of the characteristic point on the at least one cardiac image signal, and calculating a slope of the two-point connection as a deceleration rate of the aortic valve blood flow velocity; Obtaining a maximum characteristic point of the atrial systolic blood flow of the pulmonary valve and a trough point before the characteristic point on the at least one cardiac image signal, and calculating a slope of the two-point connection as an increasing rate of pulmonary valve blood flow velocity; or The maximum characteristic point of the atrial systolic blood flow of the pulmonary valve and the trough point of the characteristic point are obtained on the at least one cardiac image signal, and the slope of the two-point connection is calculated as a deceleration rate of the pulmonary valve blood flow velocity; One or any combination thereof.