TWI594743B - Bionic artificial crystal body - Google Patents

Description

Biomimetic artificial crystal

This invention relates to an optical component, and more particularly to a biomimetic artificial crystal.

Referring to Figures 1 and 2, the crystal lens 11 is a very important structure in the eyeball 1, and the crystal lens 11 is a transparent body having a lenticular shape, like a circular lentils. The outer layer of the crystal lens 11 is covered with a colorless transparent film called a crystal capsule 12. The front surface of the crystal lens 11 is flat and the rear surface is convex. The front side is directly connected to the back of the iris 13 (that is, the back of the pupil), and the rear side is followed by the vitreous cavity 14. The periphery of the crystal lens 11 is called the equatorial portion and has many ciliary bodies. The fibers of the belt 15 are attached, and the crystal lens 11 is fixed at a certain position, and does not drift with the rotation of the eyeball 1. However, the crystal lens 11 has two main functions in the eyeball 1, one is the accommodation function, which is clear and transparent and changes its refractive power by the change of its thickness, so that the eye can be seen as far and near as clearly. Especially when the eye 1 is looking at the close object, the ciliary muscle 16 contracts and the ciliary body band 15 relaxes. The crystal lens 11 is thickened by its own elastic force, which increases the refractive power, and the near object can be very clear (see Fig. 2). Shown). Another function is that the crystal 11 has a strong absorption force for ultraviolet rays (especially ultraviolet A, wavelengths of 300 nm to 400 nm), and can prevent ultraviolet rays from directly irradiating to the retina 17, causing damage to the retina 17.

The crystal lens 11 itself has a complicated metabolic process to maintain its transparency, and the nutrient in the aqueous humor is absorbed through the capsule of the hydrogel capsule 12 and the metabolic production is discharged. If the permeability of the aqueous humor component or the crystal capsule 12 changes or a certain factor affects the metabolic process of the crystal lens 11, the crystal lens 11 is turbid and a cataract is formed.

Referring to Figures 3 and 4, however, cataract patients typically undergo surgery to remove the turbid crystal lens 11 and implant an artificial crystal lens 18 into the crystal capsule 12 to restore normal eyesight function of the eyeball 1. A conventional artificial crystal 18 has a lens body 181 and two struts 182 which are oppositely disposed on the periphery of the lens body 181 and extend outward. The artificial crystal 18 is stretched by the support wings 182 to the crystal capsule 12 to position the lens body 181. The body of the artificial crystal lens 18 corresponds to the largest visual light area. Since it is installed in the crystal lens capsule 12, it is about 6 mm in diameter, and the actual visible light area minus the pupil shielding is about 5 mm in diameter. The lens body 181 has a centrally located refractive region 183 and a diffraction region 184 extending outwardly from the periphery of the refractive region 183. The refraction area 183 can bend the light to the retina 17 when the light penetrates the lens body 181, and the diffraction area 184 has a structure in which the diffraction step height is gradually decreased outward from the outer edge of the refraction area 183. The distance light is focused on the retina 17. However, in order to facilitate the installation of the artificial crystal 18 into the crystal capsule 12, causing the visible light area to shrink, and the design of the zoom partition structure of the lens body 181, the above factors collectively cause light to pass through the lens body. The total amount of 181 that reaches the retina 17 after entering is reduced, resulting in a darker visual sense, but it is prone to night blindness.

Accordingly, it is an object of the present invention to provide a large light zone and Bright bionic artificial crystals.

Thus, the biomimetic artificial crystal of the present invention is suitably disposed in a crystal capsule connected to a ciliary muscle by a ciliary body zonule to replace the removed crystal, comprising a front surface and a rear surface.

The front surface cooperates with the rear surface to form a soft foldable convex lens body. The convex lens body has a diameter of 7.0 mm to 9.5 mm. The convex lens body has a refractive index of 1.35 to 1.57.

Wherein the convex lens body is disposed in the hydro-crystal capsule and the peripheral portion of the convex lens body abuts against the inner surface of the ciliary body zonule against the lens capsule, when the contraction of the ciliary muscle contracts and the ciliary shape The small strip drives the convex lens body to deform, thereby adjusting the diopter of the convex lens body.

The effect of the invention is that the biomimetic artificial crystal has a large light area and is a soft deformable convex lens body, so it is placed in the crystal capsule, and can be deformed by the driving of the ciliary body strip, thereby adjusting The diopter of the convex lens body has a viewing function that can be seen from a near view, and also has the advantage of having a large light area to obtain a bright effect.

The above and other technical contents, features and advantages of the present invention will be apparent from the following detailed description of the preferred embodiments.

Referring to FIG. 5, FIG. 6, and FIG. 7, a preferred embodiment of the biomimetic artificial crystal of the present invention is adapted to be disposed in a crystal capsule 12 connected to a ciliary muscle 16 by a ciliary body strip 15 to replace The removed crystal lens includes a front surface 2, a rear surface 3, and two opposite end edges respectively opposite to the front surface 2 The edge and the peripheral surface 4 of the rear surface 3 are connected to each other.

The front surface 2, the rear surface 3 and the circumferential surface 4 cooperate to form a soft foldable convex lens body 5. The convex lens body 5 has a diameter of 7.0 mm to 9.5 mm. The convex lens body 5 has a refractive index of 1.35 to 1.57. An acute angle 6 is formed at the junction of the circumferential surface 4 and the rear surface 3, and the curvature of the acute angle 6 is less than 1.00 mm. Preferably, the curvature of the acute angle 6 is less than 0.10 mm. The acute angle 6 is connected to the inner surface of the ciliary body strip 15 by the lens capsule 12.

Preferably, the biomimetic artificial crystal is made of a hydrogel material composed of hydroxyethyl methacrylate (HEMA) having a water content of 35% to 55% and Its refractive index is between 1.47 and 1.57. In addition, the biomimetic artificial crystal can also be made of a hydrophobic acrylic material composed of a copolymer of acrylate and methacrylate, and the water content thereof. Less than 5% and its refractive index is between 1.47 and 1.57. In addition, the biomimetic artificial crystal may further comprise an ultraviolet absorber and a dye, the ultraviolet absorber being composed of one of a monoethyl ester and a benzophenone, the dye being selected from the group consisting of [2-naphthalenesulfonic acid, 7 -(Acetylamino)-4-hydroxy-3-((4-((2-(sulfonyloxy)ethyl))sulfonyl)phenyl)azo)-](Reactive Orange 78[2-naphthalenesulfonic acid ,7-(acetylamino)-4-hydroxy-3-((4-((2-(sulfooxy)ethyl)sulfonyl)phenyl)azo)-]CAS Reg.No.68189-39-9), [Benzenesulfonic acid , 4-(4,5-Dihydro-4-((2-methoxy-5-methyl-4-((2-(sulfonyloxy)ethyl)sulfonyl)phenyl)azo) -3-methyl-5-oxy-1hydro-pyrazol-1-yl-] (Reactive Yellow 15[2-benzensulfonic acid,4- (4,5-dihydro-4-((2-methoxy-5-methyl-4-((2-(sulfooxy)ethyl)sulfonyl)phenyl)azo)-3-methyl-5-oxo-1H-pyrazol-1 -yl-]CAS Reg.No.60958-41-0), [1,3-benzenedisulfonic acid, 4-((5-aminocarbonyl-1-ethyl-1,6-dihydro-2-hydrogen) Oxy-4-methyl-6-oxy-3-pyridyl)azo)-6-(4,6-dichloro-1,3,5-cubic azo-2-yl)amino]- ,DiNa salt](CIReactive Yellow 86[1,3-benzendisulfonic acid,4-((5-aminocarbonyl-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxo-3- Pyridinyl)azo)-6-(4,6-dichloro-1,3,5-triazin-2-yl)amino]-,disodium salt] CAS Reg.No.61951-86-8),[Copper, (29 Hydrogen, 31 hydrogen-phthalocyanine (2-)-nitrogen 29, nitrogen 30, nitrogen 31, nitrogen 32)-sulfo((4-((2-sulfonyloxy)ethyl)sulfonyl)phenyl) Amino)sulfonyl derivatives] (Reactive Blue 21[copper,(29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32)-sulfo((4-((2-(sulfooxy)ethyl)sulfonyl) )phenyl)amino)sulfonyl derivs] CAS Reg.No.73049-92-0) and [2- onion-sulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-(( 3-((2-(sulfonyloxy)ethyl)sulfonyl)phenyl)amino)-, disodium salt] (Reactive Blue No. 19 [2-anthracene-sufonic acid, 1-amino-9, 10 -dihydro-9,10-dioxo-4-((3-((2-(sulfooxy)ethyl)sulfonyl)phenyl)amino)-, disodium salt] CAS Reg. No 2580-78-1), and one of the aforementioned combinations .

More preferably, the convex lens body 5 can be any one of a lenticular lens, a plano-convex lens and a lenticular lens, and the front surface 2 and the rear surface 3 of the convex lens body 5 are respectively a bendable free curved surface. The front surface 2 cooperates with the curvature change of the rear surface 3 such that the diopter of the convex lens body 5 Between +5D and +35D.

Wherein, when the contraction of the ciliary muscle 16 contracts and the convex lens body 5 is deformed by the ciliary body strip 15, the diopter of the convex lens body 5 is adjusted (as shown in FIGS. 7 and 8).

FIG. 9 and FIG. 10 respectively illustrate that the convex lens body 5 of FIG. 7 and FIG. 8 is deformed by the ciliary body strip 15 so that the focal length thereof changes, that is, the diopter changes, and the viewing function of the near-looking distance is achieved.

The following are the processing methods for three kinds of biomimetic artificial crystals, and different materials are selected.

1. Turning is performed using the HF-1.2UVX universal blank of the US BENZ company. The diameter of the blank is 12.7 mm, the thickness is 3.0 mm, the refractive index is 1.48, and the water content is less than 4% (please confirm). The transmittance is greater than 99%. The blank was turned using a US-made optoform CNC machine at a temperature of -20 ° C and a humidity of 32% to 42%. The diamond tool used had a tip curvature of 0.02 mm and a rotational speed of 8000 rpm to 10,000 rpm. The speed of the roughing of the infeed is 18mm/min, the speed of the infeed is 10mm/min, and the amount of roughing is 0.12mm, the amount of fine machining is 0.03mm, and then the high speed is 50,000rpm. After polishing, a biomimetic artificial crystal with a diopter of +20.0D is obtained. The biomimetic artificial crystal has a diameter of 8.60 mm, a light region diameter of more than 7.00 mm, a thickness of 1.05 mm, an MTF value of 0.52 to 0.58, and an acute angle curvature of less than 0.05 mm. Outside the peripheral area of the pupil, which is slightly obscured by the pupil, light can pass through the area of the artificial crystal.

2. The biomimetic artificial crystal is produced by a rotary molding process. A mold was prepared, and the composition of the mold was as shown in Table 1 below. The mold is poured into a plastic mold for spin molding, the plastic mold has a circular opening, a curved bottom surface, and a vertical circumferential surface connected between the opening and the periphery of the bottom surface. a groove, the opening diameter is 7.95mm, the maximum depth of the groove (sagittal depth) of 1.20mm, the radius of curvature at the center of the bottom surface is 3.70mm, the curvature radius of the gradient of the bottom surface at the periphery of 9.20mm, the The height of the vertical circumferential surface is 0.05 mm. Then, the mold was spin-molded under the following process conditions, and a volume of 37 ml of the mold was poured into a nitrogen-filled environment, and the plastic mold was rotated at a rotation speed of 15 rpm while having a strength of ²⁰ mw/cm ² to 30 mw. The ultraviolet rays of /cm ² were irradiated for 30 minutes. The spin-molded lens blank was subjected to extraction in pure water at a temperature of 90 ° C for 24 hours, and then taken out in a 0.9% by weight sodium chloride (NaCl) solution to obtain a water content of 45. %, bionic artificial crystals having a diameter of 8.9 mm, a center thickness of 1.3 mm, an acute angle of curvature of 0.02 mm, and a refractive index of 1.423. The biomimetic artificial crystal was measured by a NIKON PL2 metric meter and the measurement range was a circular area of 3 mm in diameter at the center, and the measured diopter was +16D.

3. The biomimetic artificial crystal is produced by a compression molding production method. A mold slurry is prepared, and the composition of the mold is as shown in Table 2 below. The mold was poured into a plastic mold for compression molding. The plastic mold has an upper mold member and a lower mold member. The upper mold member has a groove for accommodating the mold and having a circular opening, a curved bottom surface, and a vertical circumferential surface connected between the opening and the periphery of the bottom surface, the opening having a diameter of 8.60 mm, the concave portion The maximum depth of the groove is 0.10 mm, the radius of curvature at the center of the bottom surface is 30.15 mm, and the radius of curvature at the periphery of the bottom surface is 35.32 mm. The lower mold member has a groove for accommodating the mold and having a circular opening, a curved bottom surface, and a vertical circumferential surface connected between the opening and the periphery of the bottom surface, the opening having a diameter of 8.60 mm, the concave portion The maximum depth of the groove is 1.02 mm, the radius of curvature at the center of the bottom surface is 4.08 mm, and the radius of curvature at the periphery of the bottom surface is gradually changed to 10.12 mm. Then, the mold was molded under the following process conditions, and a volume of 26 ml of the mold was poured into a nitrogen-filled environment, and ultraviolet rays having a strength of ²⁰ mW/cm ² to 30 mW/cm ² were used for 30 minutes. Irradiation. The lens blank after the molding of the mold is firstly extracted by an isopropanol (IPA) solution for 6 hours, and then extracted in pure water at a temperature of 90 ° C for 24 hours to obtain a water content of less than 3 %, bionic artificial crystals having a diameter of 8.6 mm, a center thickness of 1.05 mm, an acute angle of 0.06 mm, and a refractive index of 1.512. The biomimetic artificial crystal was measured by a NIKON PL2 metrology meter and measured in a circular area of 3 mm in diameter at the center, and the measured diopter was +18 D.

In summary, the biomimetic artificial crystal of the present invention is a soft and deformable convex lens body 5, and thus is placed in the crystal capsule 12, and can be deformed by the driving of the ciliary body strip 15 to adjust the convex lens. The diopter of the body 5 reaches a viewing function that can be seen from a near view, and is only covered by the iris It has a large visible light area, does not affect the amount of light reaching the retina, and achieves the effect of bionics close to the original crystal. Therefore, the object of the present invention can be achieved.

The above is only the preferred embodiment of the present invention, and the scope of the invention is not limited thereto, that is, the simple equivalent changes and modifications made by the scope of the invention and the description of the invention are All remain within the scope of the invention patent.

11‧‧‧Water Crystal

12‧‧‧Aquarium sac

15‧‧‧Ciliary body zonule

16‧‧‧Ciliary muscle

2‧‧‧ front surface

3‧‧‧Back surface

4‧‧‧Week

5‧‧‧ convex lens body

6‧‧‧ acute angle

1 is a schematic view showing the configuration of an eyeball and a ciliary muscle in a relaxed state; FIG. 2 is a schematic view showing the configuration of the eyeball and the contraction state of the ciliary muscle; FIG. 3 is a conventional artificial crystal. Figure 4 is a schematic view showing the artificial crystal lens implanted in the eyeball; Figure 5 is a side view of a preferred embodiment of the biomimetic artificial crystal of the present invention; Figure 6 is a partial enlarged view of the preferred embodiment Figure 7 is a schematic view showing the preferred embodiment implanted in the eyeball and the ciliary muscle in the relaxed state; Figure 8 is a schematic view showing the preferred embodiment implanted in the eyeball and the eyelash The muscle is in the contracted state; FIG. 9 is a schematic view showing the refractive state of the preferred embodiment of FIG. 7; Figure 10 is a schematic view showing another refractive state of the preferred embodiment of Figure 8.

2‧‧‧ front surface

3‧‧‧Back surface

4‧‧‧Week

5‧‧‧ convex lens body

6‧‧‧ acute angle

Claims (9)

A biomimetic artificial crystal, which is disposed in a crystal capsule connected to a ciliary muscle by a ciliary body zonule to replace the removed crystal. The artificial crystal is integrally formed and includes a front surface and a rear surface. The front surface cooperates with the rear surface to form a soft foldable convex lens body, and the front surface cooperates with the curvature change of the rear surface such that the convex power of the convex lens body is between +5D and +35D, and the diameter of the convex lens body Between 7.0 mm and 9.5 mm, the convex lens body has a refractive index of 1.35 to 1.57, wherein the convex lens body is disposed in the crystal capsule and the peripheral portion of the convex lens body is coupled to the ciliary body zonule against the lens capsule The inner surface of the convex lens body is adjusted when the contraction of the ciliary muscle is contracted and the convex body of the convex lens is deformed by the ciliary body zonule, thereby adjusting the diopter of the convex lens body. The bionic artificial crystal according to claim 1, wherein at least one of the front surface and the rear surface is a bendable free-form surface and at the same time has a function of eliminating the peripheral spherical phase difference. The biomimetic artificial crystal according to claim 2, which is composed of a hydrocolloid material, which is composed of hydroxyethyl methacrylate, and the water-containing material has a water content of 35% to 55% and The refractive index is between 1.35 and 1.45. The biomimetic artificial crystal according to claim 2, which is composed of a hydrophobic acrylic material, which is a copolymer composed of acrylate and methyl acrylate, and has a water content of less than 5%. Its refractive index is between 1.47 and 1.57. The biomimetic artificial crystal according to claim 2, wherein the convex lens body is any one of a meniscus lens, a plano-convex lens and a lenticular lens. The biomimetic artificial crystal according to claim 2, further comprising a circumferential surface opposite to an end edge of the front surface and an end edge of the rear surface, the front surface, the rear surface and the circumferential surface Forming the convex lens body, the peripheral surface forms an acute angle with the rear surface, and the acute angle has a curvature of less than 1.00 mm, and the acute angle is dependent on the inner surface of the liquid crystal capsule connecting the ciliary body strip The ciliary body strip is driven to deform the convex lens body. The biomimetic artificial crystal according to claim 6, wherein the acute angle has a curvature of less than 0.10 mm. The biomimetic artificial crystal according to claim 2 or 3, further comprising an ultraviolet absorber which is composed of one of an ethyl ester and a benzophenone. A biomimetic artificial crystal according to claim 2 or 3, further comprising a dye selected from the group consisting of [2-naphthalenesulfonic acid, 7-(acetylamino)-4-hydroxy-3-((4-((2) -(sulfonyloxy)ethyl)sulfonyl)phenyl)azo)-],[benzenesulfonic acid, 4-(4,5-dihydro-4-((2-methoxy-5-) 4-((2-(sulfonyloxy)ethyl)sulfonyl)phenyl)azo)-3-methyl-5-oxy-1hydro-pyrazol-1-yl-], [1,3-benzenedisulfonic acid, 4-((5-aminocarbonyl-1-ethyl-1,6-dihydro-2-hydroxy-4-methyl-6-oxy-3-pyridine) Azo)-6-(4,6-dichloro-1,3,5-cubic azo-2-yl)amino]-, disodium salt], [copper, (29 hydrogen, 31 hydrogen- Phthalocyanine (2-)-nitrogen 29, nitrogen 30, nitrogen 31, nitrogen 32)-sulfo((4-((2-sulfonyloxy)ethyl)))sulfonyl)phenyl) Sulfhydryl derivative], [2-onion-sulfonic acid, 1-amino-9,10-dihydro-9,10-dioxo-4-((3-((2-(sulfonyloxy)oxy) Ethyl)sulfonyl)phenyl)amino)-, disodium salt], and one of the foregoing combinations.