TWI578970B - A patch for promoting wound healing - Google Patents

Description

a material that promotes wound healing

The present invention relates to a dressing, and more particularly to a dressing that promotes wound healing.

The dressing is often used to cover human skin wounds or to be attached to the transmembrane or muscle lesions. The conventional dressing material has a relatively one surface layer and an applicator layer, and the applicator layer contains a drug, which can isolate the fragile wound from the outside, prevent the recurrent infection, and protect the wound from external force collision, which contains The drug also repairs injured muscle tissue, allowing the body to heal naturally in an environment that is fully protected, low in bacteria, and has appropriate therapeutics.

In order to increase the rate of wound healing, another conventional dressing material has special physical properties, such as thermal conductivity or electrical conductivity, to physically promote the release of the drug in the conventional dressing and enhance the body's ability to absorb the drug. Please refer to FIG. 1 , which is a perspective view of the conventional dressing material. The conventional dressing 9 comprises a surface layer 91 , a conductive layer 92 and a wire 93 . The surface layer 91 and the conductive layer 92 are clamped together. One end of the wire 93, the other end of the wire 93 is connected to a frequency therapy machine M, the conductive layer 92 contains a therapeutic drug, and the frequency therapy machine M is used to generate a micro current. When the patient uses the conventional dressing material 9, the conductive layer 92 is attached to the skin, and the electric frequency therapy machine M is turned on, so that the conductive layer 92 releases the drug on the one hand, and can simultaneously pass the micro current on the other hand. It activates the cells around the wound to increase the absorption of the drug by the wound and promote wound healing. The structure similar to the conventional dressing 9 has been disclosed in the sixth drawing of the Patent No. 325411 of the Republic of China.

Although the above-mentioned conventional dressing 9 can be supplemented with physical treatment, the wound healing effect is accelerated. Rate, however, the conventional dressing material 9 must be connected to the frequency therapy machine M to output a micro current to the conductive layer 92, since the price of the frequency therapy machine M is high, and when the user sticks the conventional dressing material 9 At this time, the action is not easily moved by the radio frequency therapy machine M, and thus the threshold and the burden of the use of the conventional dressing material 9 are increased, which causes considerable inconvenience to the patient.

In view of the above, it is necessary to provide a dressing material which can promote wound healing to solve the problem that the conventional dressing material 9 is required to be connected to a large voltage device.

The present invention provides a dressing that promotes wound healing, which is capable of producing a microcurrent output through a stretched dressing.

The present invention provides a dressing for promoting wound healing, comprising: a soft substrate having a first surface and a second surface; a first electrode group disposed on the first surface The first electrode group includes a first positive electrode, a first negative electrode, a first conductive line, and a second conductive line. The first positive electrode is electrically connected to the first conductive line, and the first The negative electrode is electrically connected to the second conductive line; and at least one discharge fiber is coated on the first electrode group, and the discharge fiber is respectively connected to the first conductive line and the second conductive line at different portions; Wherein, a central portion of the first surface is provided with a depletion region, and the first electrode group and the discharge fiber are disposed outside the depletion region.

The dressing for promoting wound healing of the present invention, wherein the material of the discharge fiber is a biodegradable substance.

The dressing for promoting wound healing of the present invention, wherein the discharge fiber contains a drug.

The dressing for promoting wound healing of the present invention, wherein the number of the discharge fibers is several, and the plurality of discharge fibers are radially extended from the edge of the depletion region toward the edge of the first surface.

The dressing for promoting wound healing of the present invention, wherein the first conductive thread package The first connecting wire and the at least one first extending wire are connected to the first positive electrode by the first connecting wire, and the second conductive wire comprises a second connecting wire and at least one And a second extension wire connected to the first negative electrode by the second connection wire.

The dressing for promoting wound healing according to the present invention, wherein the first extension wire extends from the first connecting wire toward the first negative electrode, and the second extending wire is oriented from the second connecting wire toward the first A positive electrode extends in the direction.

The present invention is capable of promoting wound healing, wherein the first extension wire and the second extension wire are disposed outside the depletion region, and the discharge fibers are respectively connected to the first extension wire at different portions and the The second extension wire.

The present invention is capable of promoting wound healing, wherein the number of the first extension wire and the second extension wire is several, and the plurality of first extension wires are connected to the first connection wire, and the plurality of the first Two extension wires are connected to the second connection wires.

The present invention is capable of promoting wound healing, wherein a plurality of the first extension wires are interdigitated with a plurality of the second extension wires, so that the plurality of the first extension wires and the plurality of the second extension wires are indexed Arranged in a fork.

The present invention is capable of promoting wound healing, wherein a second electrode group is further disposed, the second electrode group includes a second positive electrode, a second negative electrode, a third conductive line and a fourth conductive line. The second positive electrode is electrically connected to the third conductive line, and the second negative electrode is electrically connected to the fourth conductive line, and the discharge fiber is respectively connected to the third conductive line at different portions and the The fourth conductive line.

The present invention is capable of promoting wound healing, wherein the first surface is further provided with a conductive region, the conductive region is disposed outside the depletion region, and the first electrode group and the second electrode group are respectively disposed on the conductive layer The first conductive line, the second conductive line, the third conductive line and the fourth conductive line ring are disposed outside the depletion area.

The dressing for promoting wound healing of the present invention, wherein the first electrode group and the second electrode group are symmetrically disposed in the conductive region.

The present invention is capable of promoting wound healing, wherein the first surface is provided with a receiving groove formed by the first surface being recessed toward the second surface, the first positive electrode and the first positive electrode The second negative electrode is disposed outside the accommodating groove, and the first conductive line and the second conductive line are disposed in the accommodating groove.

The present invention can promote the wound healing material, wherein the discharge fiber is caused by the electric charge generated by the natural activity of the human body, so that the first electrode group generates a micro current, and no additional heavy and high-priced voltage equipment is needed. The utility of increasing the ease of use and saving the cost of applying the dressing which promotes wound healing is achieved.

〔this invention〕

1‧‧‧Soft substrate

11‧‧‧ first surface

111‧‧‧ Vacant Zone

112‧‧‧Conducting area

12‧‧‧ second surface

2‧‧‧First electrode group

21‧‧‧First positive electrode

22‧‧‧First negative electrode

23‧‧‧First conductive line

231‧‧‧First connecting wire

232‧‧‧First extension wire

24‧‧‧Second conductive line

241‧‧‧First connecting wire

242‧‧‧Second extension wire

3‧‧‧discharge fiber

31‧‧‧ first end

32‧‧‧second end

4‧‧‧Second electrode group

41‧‧‧second positive electrode

42‧‧‧second negative electrode

43‧‧‧ third conductive line

431‧‧‧ Third connecting wire

432‧‧‧ Third extension wire

44‧‧‧fourth conductive line

441‧‧‧fourth connecting wire

442‧‧‧4th extension wire

L‧‧‧ interval length

T‧‧‧容槽

[study]

9‧‧‧Used materials

91‧‧‧ surface layer

92‧‧‧ Conductive layer

93‧‧‧Wire

M‧‧‧frequency therapy machine

Figure 1 is a perspective view of a conventional dressing.

Figure 2 is a plan view of a first embodiment of a dressing of the present invention which promotes wound healing.

Figure 3 is a cross-sectional view showing the combination of the first embodiment of the dressing of the present invention which promotes wound healing.

Figure 4 is a combined cross-sectional view of a second embodiment of the dressing of the present invention which promotes wound healing.

The above and other objects, features and advantages of the present invention will become more <RTIgt; <RTIgt; </ RTI> <RTIgt; </ RTI> <RTIgt; The top view and the combined cross-sectional view of the first embodiment of the present invention for promoting wound healing, wherein the wound material for promoting wound healing comprises a soft substrate 1, a first electrode group 2 and at least one discharge. Fiber 3. The first electrode group 2 and the discharge fiber 3 are disposed on one surface of the flexible substrate 1, and the discharge fiber 3 is connected to the first electrode group 2, so that the discharge fiber 3 is stressed and stretched or pulled. The charge generated during stretching can be conducted to the first electrode group 2, so that the material capable of promoting wound healing can pass through the human body. Natural activity produces microcurrents that activate cells in the vicinity of the wound to improve wound healing efficiency.

In addition, the dressing for promoting wound healing of the present invention has a medicine for curing a human wound through the medicine, and the medicine may be located on the first surface 11 of the soft substrate 1, or the discharge fiber 3 may contain the medicine. Here, the member site containing the drug component is not limited as long as the drug can be released when it is attached to the skin, and the drug component can be adjusted depending on the type of wound to be treated, and the present invention is not limited.

In detail, the flexible substrate 1 is used to set the drug in the dressing capable of promoting wound healing and an electrical system for promoting absorption of the drug by the human body, so that the articles can pass through the soft substrate. 1 adheres to human skin, and the flexible substrate 1 has flexibility and elasticity, so that the dressing capable of promoting wound healing can cause relative deformation of muscle contraction or joint activity at the attachment site. In detail, the flexible substrate 1 has a first surface 11 and a second surface 12, and the flexible substrate 1 can pass through its own viscosity or another adhesive material (such as a gas permeable adhesive tape or the like). In the present embodiment, the first surface 11 of the flexible substrate 11 is viscous, so that the user can apply the first surface 11 to the wound which can promote wound healing. Attached to the human body. The material of the flexible substrate 1 of the present embodiment is Polyimide (PI), but it should not be limited thereto.

In order to attach the dressing capable of promoting wound healing to the joint of the human body, a larger amount of micro current can be generated through the joint activity to activate the cells, preferably, according to the first electrode group 2 and the discharge fiber 3 The first surface 11 can be divided into a depletion region 111 and a conductive region 112. The depletion region 111 is disposed at the center of the first surface 11 , and the conductive region 112 is located outside the depletion region 111 . The first electrode group 2 and the discharge fiber 3 are disposed in the conductive region 112. The user can attach the dressing capable of promoting wound healing to the injured skin located on the joint in the deficient area 111, thereby generating more electric charge in the dressing capable of promoting wound healing during the active joint. Follow-up will be explained later.

Referring to FIG. 2 again, the first electrode group 2 is disposed on the first surface 11 Preferably, the first electrode group 2 includes a first positive electrode 21, a first negative electrode 22, a first conductive line 23 and a second conductive line 24, the first The positive electrode 21 is electrically connected to the first conductive line 23 , and the first negative electrode 22 is electrically connected to the second conductive line 24 . In more detail, the first conductive wire 23 of the embodiment includes a first connecting wire 231 and at least one first extending wire 232. The first extending wire 232 is connected to the first connecting wire 231 by the first connecting wire 231. The first conductive electrode 24 includes a second connecting wire 241 and at least one second extending wire 242. The second extending wire 242 is connected to the second connecting wire 241 through the second connecting wire 241. a negative electrode 22, and the first positive electrode 21 and the first negative electrode 22 are disposed on opposite sides of the conductive region 112, and the first extended wire 232 is oriented by the first connecting wire 231 toward the first negative The direction of the electrode 22 extends, and the second extension wire 242 also extends from the second connection wire 241 toward the first positive electrode 21.

Preferably, the number of the first extension wire 232 and the second extension wire 242 are several, so that the first electrode group 2 can collect a larger amount of electric charge by stretching the muscle or the joint, and several of the first extensions. The wire 232 and the plurality of second extension wires 242 are interlaced with each other. Preferably, the plurality of first extension wires 232 and the plurality of second extension wires 242 are arranged in a fork shape, thereby improving the first electrode group 2 The space utilization efficiency of the conductive region 112 is set to miniaturize the size of the dressing which can promote wound healing, so that the dressing of the present invention which can promote wound healing can be applied to human body parts of various wound sizes.

The discharge fiber 3 is located in the conductive region 112 and covers the first electrode group 2, and the discharge fiber 3 has a first end 31 and a second end 32. The first end 31 is disposed in the depletion region. The edge of the 111, the second end 32 is disposed at the edge of the first surface 11. The number of the discharge fibers 3 is preferably several, and a plurality of the discharge fibers 3 extend radially from the edge of the depletion region 111 toward the edge of the first surface 11, so that the material capable of promoting wound healing can correspond to human nature. Activities such as muscle contraction or joint flexion and extension produce more microcurrent.

Referring to FIGS. 2 and 3, the discharge fiber 3 of the present embodiment has a long filament shape, and the discharge fiber 3 is connected to the first conductive line 23 and the second conductive line 24 at different portions. For ease of explanation and to enable those of ordinary skill in the art to understand the meaning of the present invention, a portion between the first end 31 and the second end 32 of the discharge fiber 3 is defined herein. The distance between the first ends 31 is a gap length L, and the discharge fibers 3 are respectively connected to the first extension wire 232 and the second extension wire 242 at different portions of the interval length L, when the first When the electrode group 2 is provided with a plurality of the first extension wires 232 and a plurality of the second extension wires 242 (as shown in FIG. 2 of the embodiment), the first end 31 to the second end 32 of the discharge fiber 3 The first extension wire 232, the second extension wire 242, the first extension wire 232, the second extension wire 242, and the first extension wire 232 are sequentially connected.

The discharge fiber 3 of the present embodiment contains a drug, and the material of the discharge fiber 3 is preferably a biodegradable substance such as Poly-L-Lactic-Acid (PLLA) or polycaprolactone (Polycaprolactone). , abbreviated as PCL) or polylactide (PLA), such that the pharmaceutical ingredient is gradually released during the decomposition of the discharge fiber 3 to improve the efficiency of the body to absorb the drug.

The discharge fiber 3 can be prepared by different methods. The discharge fiber 3 of the embodiment is obtained by using a near-field electrospinning (NFES) process. In detail, the embodiment Is a mixture of L-lactic acid and a drug solution to form a spinning solution, wherein the drug solution contains 0.5% to 50% of the drug, and then the spinning solution is injected into a syringe equipped with a stainless steel needle of a suitable size, and The syringe is fixed to the micro-injection pump, and the syringe is placed on a collecting plate, and the soft substrate 1 of the first electrode group 2 is disposed on the first surface 11 on the surface of the collecting plate. The first surface 11 of the flexible substrate 1 faces upward, and covers the depletion region 111 with a mask. The stainless steel needle is continuously applied with a positive high voltage (about 4,000 to 8000 V), and the collection plate is subjected to a negative Voltage (about -100~-1200V), at this time, a spinning solution that is simultaneously subjected to pump propulsion and electric field, in the stainless steel The tip of the needle ejects the spinning solution toward the first surface 11 in the direction of the electric field, and the spinning solution is solidified on the first surface 11, and then the covering material is removed, that is, the discharging fiber is formed in the conductive region 112 of the first surface 11. 3, and at the same time complete the preparation of the dressing which promotes wound healing. Only one preparation method of the discharge fiber 3 is shown here, but it is not limited thereto.

The second electrode group 4 includes a second positive electrode 41, a second negative electrode 42, and a third conductive wire 43, and the second electrode group 4 is further provided. a fourth conductive line 44 electrically connected to the third conductive line 43, the second negative electrode 42 is electrically connected to the fourth conductive line 44, and the discharge fiber 3 is covered by The second electrode group 4 is connected to the third conductive line 43 and the fourth conductive line 44 at different locations. The second electrode group 4 and the first electrode group 2 are respectively disposed on opposite sides of the conductive region 112 and are preferably symmetrical to each other, that is, the first positive electrode 21 and the first negative electrode 22 respectively The two positive electrodes 41 and the second negative electrode 42 are symmetrical. In addition, the third conductive line 43 includes a third connecting wire 431 and at least one third extending wire 432. The fourth conductive wire 44 includes a fourth connecting wire 441 and at least one fourth extending wire 442. The connection and the relationship with the discharge fiber 3 are the same as those of the first conductive line 23 and the second conductive line 24, and are not described here. In this embodiment, the first extension wire 232 and the second extension are used. The wire 242, the third extension wire 432 and the fourth extension wire 442 are collectively disposed outside the depletion zone 111.

When applying the dressing capable of promoting wound healing according to the present invention, the patient attaches the dressing capable of promoting wound healing to the skin with the first surface 11, and when it engages in natural labor work, muscle contraction and relaxation, or joints In the case of bending and stretching, the flexible substrate 1 is flexible, and the discharge fiber 3 provided on the flexible substrate 1 is deformed along with the flexible substrate 1, and the discharge fiber 3 is a piezoelectric device. The stress generated by the deformation of the flexible substrate 1 changes the electric dipole moment inside the discharge fiber 3, so that the discharge fiber 3 generates a positive or negative charge along the stress direction, and the discharge fiber 3 is different in two or two. Electricity is generated between the portions of the interval length L The voltage difference is such that the first conductive line 23 and the second conductive line 24 connected to the discharge fiber 3 have different voltage values, and the voltage difference between the first conductive line 23 and the second conductive line 24 respectively accumulates Up to the first positive electrode 21 and the first negative electrode 22 to release a microcurrent from the first positive electrode 21 and the second negative electrode 22, thereby activating cells in the vicinity of the wound, supplemented by microcurrents to make the human body more easily absorbed The drug increases the efficiency of wound healing.

Therefore, when the first electrode group 2 and the discharge fiber 3 are disposed outside the depletion region 111, and the plurality of discharge fibers 3 are radially extended from the edge of the depletion region 111 toward the edge of the first surface 11, the A dressing that promotes wound healing is particularly suitable for application to wounds located at joints. In detail, when the joint is active, the plurality of discharge fibers 3 are subjected to the same stress direction (for example, when the joint is bent, the direction of the stress of the plurality of discharge fibers 3 is from the depletion region 111 toward the conductive region 112. When the joint is straightened, the plurality of discharge fibers 3 are stressed in a direction from the conductive region 112 toward the depletion region 111), and the first extension wire 232 covered by the plurality of discharge fibers 3 or The charges collected by the second extension wires 233 do not cancel each other, thereby increasing the amount of current generated by the potential difference between the first positive electrode 21 and the first negative electrode 22.

Referring to FIG. 3, which is a sectional view of a first embodiment of the present invention for promoting wound healing, the first electrode group 2 is disposed on the first surface 11 of the flexible substrate 1, and The discharge fiber 3 further covers the first extension wire 232 and the second extension wire 242, and compares the horizontal height to the first positive electrode 21, the discharge fiber 3, and the first extension wire 232. (and the second extension wire 242) are arranged such that the charge generated by the stress of the discharge fiber 3 can be directly protruded after being collected by the first extension wire 232 and the second extension wire 242. The first positive electrode 21 and the first negative electrode 22 release a micro current when contacting human skin to improve the drug absorption efficiency.

Please refer to FIG. 4, which is a sectional view of a second embodiment of a dressing for promoting wound healing according to the present invention. The components of the dressing for promoting wound healing in the second embodiment and their arrangement and connection relationship are The first embodiment is similar in that the difference is in the second embodiment, the soft base The first surface 11 of the material 1 is further provided with a receiving groove t formed by the first surface 11 being recessed toward the second surface 12, the first positive electrode 21 and the first negative electrode. 22 (not shown) is disposed outside the accommodating slot t, and the first extension wire 232 and the second extension wire 242 are disposed in the accommodating groove t, and the first through the accommodating groove t The conductive wire 23 and the second conductive wire 24 have a protective effect to prevent the conductive wires 23 and 24 from falling off due to frictional collision with foreign objects or skin when the sheath for promoting wound healing is used. The dressing that promotes wound healing can maintain stress and electrical conductivity.

In summary, the first electrode group 2 and the discharge fiber 3 of the present invention for promoting wound healing are disposed on the first surface 11 of the flexible substrate 1, and the discharge fiber 3 covers the first surface. The electrode group 2 is connected to the first extension wire 232 and the second extension wire 242 at different portions, so that the electric charge generated by the stress of the discharge fiber 3 can be collected through the extension wires 232 and 242 to the first electrode. A positive electrode 21 and the first negative electrode 22 release micro-current to the surface of the skin by the first electrode group 2, thereby activating cells in the vicinity of the wound, thereby enabling the dressing of the present invention to promote wound healing to improve the wound healing rate. efficacy. Furthermore, the dressing capable of promoting wound healing transmits the micro-current of the first electrode group 2 through the electric charge generated by the discharge fiber 3 in response to the natural activity of the human body, and does not need to be connected with a cumbersome and high-priced voltage device. The utility of increasing the ease of use and saving the cost of applying the dressing which promotes wound healing is achieved.

While the invention has been described in connection with the preferred embodiments described above, it is not intended to limit the scope of the invention. The technical scope of the invention is protected, and therefore the scope of the invention is defined by the scope of the appended claims.

1‧‧‧Soft substrate

11‧‧‧ first surface

111‧‧‧ Vacant Zone

112‧‧‧Conducting area

2‧‧‧First electrode group

21‧‧‧First positive electrode

22‧‧‧First negative electrode

23‧‧‧First conductive line

231‧‧‧First connecting wire

232‧‧‧First extension wire

24‧‧‧Second conductive line

241‧‧‧First connecting wire

242‧‧‧Second extension wire

3‧‧‧discharge fiber

31‧‧‧ first end

32‧‧‧second end

4‧‧‧Second electrode group

41‧‧‧second positive electrode

42‧‧‧second negative electrode

43‧‧‧ third conductive line

431‧‧‧ Third connecting wire

432‧‧‧ Third extension wire

44‧‧‧fourth conductive line

441‧‧‧fourth connecting wire

442‧‧‧4th extension wire

Claims (13)

A soft material capable of promoting wound healing, comprising: a soft substrate having a first surface and a second surface; a first electrode group disposed on the first surface, the first The electrode group includes a first positive electrode, a first negative electrode, a first conductive line and a second conductive line. The first positive electrode is electrically connected to the first conductive line, and the first negative electrode is electrically connected. Is electrically connected to the second conductive line; and at least one discharge fiber is coated on the first electrode group, and the discharge fiber is respectively connected to the first conductive line and the second conductive line at different portions; wherein the first A depletion zone is disposed in the center of a surface, and the first electrode group and the discharge fiber are disposed outside the depletion zone. The dressing for promoting wound healing according to the first aspect of the invention, wherein the material of the discharge fiber is a biodegradable substance. The dressing for promoting wound healing as described in claim 2, wherein the discharge fiber contains a drug. The dressing for promoting wound healing according to claim 1, wherein the number of the discharge fibers is several, and the plurality of discharge fibers are radially extended from the edge of the depletion region toward the edge of the first surface. The material for promoting wound healing according to claim 4, wherein the first conductive wire comprises a first connecting wire and at least one first extending wire, wherein the first extending wire is the first extending wire The connecting wire is connected to the first positive electrode, and the second conductive wire comprises a second connecting wire and at least one second extending wire. The second extending wire is connected to the first negative electrode by the second connecting wire. The dressing for promoting wound healing according to claim 5, wherein the first extension wire is extended from the first connecting wire toward the first negative electrode. Extendingly, the second extension wire extends from the second connecting wire toward the first positive electrode. The material for promoting wound healing according to the sixth aspect of the invention, wherein the first extension wire and the second extension wire are disposed outside the depletion zone, and the discharge fibers are respectively connected to different portions. The first extension wire and the second extension wire. The material for promoting wound healing according to claim 7, wherein the number of the first extension wire and the second extension wire is several, and the plurality of first extension wires are connected to the first connection. And a plurality of the second extension wires are connected to the second connection wires. The dressing for promoting wound healing according to claim 8 , wherein the plurality of the first extension wires are interdigitated with the plurality of the second extension wires, so that the plurality of the first extension wires and the plurality of The second extension wires are arranged in the shape of a finger. The material for promoting wound healing according to claim 9 , wherein a second electrode group is further disposed, the second electrode group comprising a second positive electrode, a second negative electrode and a third conductive And a fourth conductive line electrically connected to the third conductive line, wherein the second negative electrode is electrically connected to the fourth conductive line, and the discharge fiber is respectively connected to different portions The third conductive line and the fourth conductive line. The material for promoting wound healing according to claim 10, wherein the first surface is further provided with a conductive region, the conductive region is disposed outside the depletion region, the first electrode group and the second electrode The electrode groups are respectively disposed on opposite sides of the conductive region, and the first conductive line, the second conductive line, the third conductive line, and the fourth conductive line ring are disposed outside the depletion region. The dressing for promoting wound healing according to claim 11, wherein the first electrode group and the second electrode group are symmetrically disposed in the conductive region. The accommodating material for promoting wound healing according to the first aspect of the invention, wherein the first surface is provided with a receiving groove formed by the first surface being recessed toward the second surface. The first positive electrode and the second negative electrode are disposed outside the accommodating groove, and the first conductive line and the second conductive line are disposed in the accommodating groove.