TWI542370B - Blood purification device - Google Patents

Description

Blood purification device

The present invention relates to a blood purification device.

As a blood purification device of the prior art, a blood purification device including a warmer for adjusting the temperature of a liquid flowing in an extracorporeal circulation circuit is known (see Patent Documents 1 and 2). In the blood purification device described in Patent Document 1, the blood purification device described in Patent Document 1 is configured to adjust the temperature of a liquid (blood, supplement, or the like) injected into a patient through an extracorporeal circuit to a desired temperature. In the blood purification device described in Patent Document 2, it is provided for the purpose of improving the separation and filtration function of a plasma component separator (Plasma Fractionator).

[Previous Technical Literature] [Patent Literature]

Patent Document 1: Japanese Patent Laid-Open Publication No. 2001-029459

Patent Document 2: Japanese Patent Laid-Open Publication No. 2007-215569

However, the blood pump or the like disposed in the blood purification device does not always operate continuously at the set flow rate. For example, there is also a type in which the pressure in the extracorporeal circuit is temporarily increased, and the safety is reduced in consideration of the flow rate actually transmitted from the pump (hereinafter referred to as the execution flow rate). Implementing control to reduce execution traffic in this way In the case of a blood pump or the like, if the set temperature of the warmer is fixed, there is a fear that the following problems may occur.

For example, in the blood purification device in which the warmer is disposed for the purpose of temperature adjustment of the liquid injected into the body, although the control for reducing the execution flow rate of the pump is implemented, if the set temperature of the warmer is maintained constant, the injection is performed. The temperature of the liquid in the body is likely to be higher than the desired temperature. Assuming that the temperature of the liquid rises to an undesired temperature, the composition of the liquid is adversely affected. As a result, it is conceivable that the desired therapeutic effect may not be sufficiently obtained.

On the other hand, in the case of a blood purification device equipped with a warmer for the purpose of improving the separation and filtration function of the plasma component separator, although the control for reducing the execution flow rate of the pump is implemented, if the temperature of the warmer is set Maintaining the fixation, the temperature of the liquid injected into the plasma component separator is likely to rise above the assumed value. Assuming that the temperature of the liquid rises to an undesired temperature, the composition of the liquid is adversely affected. As a result, it is conceivable that the desired therapeutic effect may not be sufficiently obtained.

Furthermore, the above-mentioned problem is not limited to the case of implementing the control for reducing the execution flow rate of the pump, and the same is true for the control for increasing the execution flow rate of the pump. If the set temperature of the warmer is maintained constant, it is conceivable that the heating is due to heating. Insufficient results may not fully achieve the desired therapeutic effect.

Further, the above problem is not limited to a blood purification device including a warmer. For example, in a blood purification therapy called a cryofiltration plasmapheresis, a blood purification device having a cooler for cooling plasma separated by a plasma separator can be used. In the blood purification apparatus including the cooler, when the control for changing the flow rate of the pump is performed, if the set temperature of the cooler is maintained at a constant temperature, it is conceivable that the cooling is excessive or the cooling is insufficient. The expected therapeutic effect may not be fully achieved.

Therefore, the present invention has been made to solve the above problems, and an object of the invention is to provide a blood purification apparatus which can sufficiently obtain an intended therapeutic effect even if the flow rate of the pump is changed.

The blood purification device of the present invention comprises: a device body detachably attached to the extracorporeal circuit; at least one pump for delivering the liquid to the extracorporeal circuit; and a heat source for flowing to the extracorporeal circuit The liquid inside is heated or cooled; and the main control unit performs various controls; and the main control unit includes an execution flow rate determining unit that determines an execution flow rate of the pump, and a pump control unit that performs the above The operation rate of the pump determined by the flow rate determining unit controls the driving of the pump, and the operating temperature determining unit determines the operating temperature of the heat source based on the execution flow rate of the pump determined by the execution flow rate determining unit. And a heat source control unit that controls heat transferred between the heat source and the liquid based on an operating temperature of the heat source determined by the operating temperature determining unit.

Preferably, the blood purification device according to the present invention further includes an input unit that inputs a flow rate value for setting an execution flow rate of the pump, wherein the execution flow rate determining unit is based on a flow rate value input to the input unit. Determine the execution flow rate of the above pump.

Further, preferably, the blood purification device according to the present invention further includes a memory unit that stores information on the execution flow rate of the pump, wherein the execution flow rate determining unit is related to the execution flow rate stored in the storage unit. Information, and determine the execution flow of the above pump.

In the blood purification device of the present invention, preferably, the heat source device is provided with a variable range that is allowed as the operating temperature, and the operating temperature is determined. The fixed portion temporarily changes the upper limit value or the lower limit value of the variable range when the operating temperature of the heat source derived from the pump flow rate is deviated from the preset variable range, and is changed after the change The operating temperature of the heat source is determined within the above-described variable range.

In the blood purification device of the present invention, the heat source device is a warmer or a cooler.

According to the blood purification device of the present invention, the operation temperature determining unit and the heat source control unit are provided. Therefore, even if the control for changing the flow rate of the pump is performed, the blood flow rate can be controlled based on the changed flow rate. The amount of heat transferred between the liquids. That is, even if the flow rate of the pump is changed, the blood or the like can be adjusted to a desired temperature, and as a result, the desired therapeutic effect can be sufficiently obtained.

1‧‧‧Blood purification system

10‧‧‧plasma separator

12‧‧‧ (plasma separator) inflow

14‧‧‧ (Peptide Separator) First Outflow

16‧‧‧ (plasma separator) second outflow

20‧‧‧Arterial side circuit

22, 32, 52‧‧‧ gas trap

24, 54, 64‧‧ ‧ Department of Transfer

30‧‧‧ Venous side circuit

40‧‧‧ plasma component separator

42‧‧‧ (in the plasma component separator) inflow section

44‧‧‧ (the plasma component separator) first outflow

46‧‧‧ (the plasma component separator) second outflow

50‧‧‧1st connection loop

60‧‧‧Circuit loop

70‧‧‧2nd connection loop

100,200‧‧‧ blood purification device

110‧‧‧ device body

120‧‧‧ blood pump

122‧‧‧plasma pump

124‧‧‧Circulating pump

130‧‧‧heat source

140‧‧‧Power Supply Department

142‧‧‧ Input Department

144‧‧‧Display Department

146‧‧‧Memory Department

160, 260‧‧‧ Main Control Department

170, 270‧‧‧ Implementation Flow Decision Department

172‧‧‧Pump Control Department

180‧‧‧Action Temperature Decision Department

182‧‧‧Hot source control department

Fig. 1 is a view for explaining the blood purification system 1 of the first embodiment.

Fig. 2 is a block diagram showing an electrical configuration of the blood purification device 100 of the first embodiment.

Fig. 3 is a block diagram showing an electrical configuration of the blood purification device 200 of the second embodiment.

Fig. 4 is a flow chart showing the driving process of the pump of the blood purification device 100 according to the first embodiment.

Fig. 5 is a flowchart showing a driving process of a heat source device of the blood purification device 100 according to the first embodiment.

Hereinafter, the blood purification device of the present invention is introduced according to the illustrated embodiment. Line description.

[First Embodiment]

First, the configuration of the blood purification system 1 and the blood purification device 100 according to the first embodiment will be described with reference to Figs. 1 and 2 .

Fig. 1 is a view for explaining the blood purification system 1 of the first embodiment. Fig. 2 is a block diagram showing an electrical configuration of the blood purification device 100 of the first embodiment.

As shown in Fig. 1, the blood purification system 1 according to the first embodiment includes an extracorporeal circulation circuit and a blood purification device 100 (see Fig. 2). The blood purification system 1 is, for example, a blood purification system for performing a warming type recycling method (also referred to as a DF thermo method or a warming-recycling type double membrane filtration plasma exchange method).

In addition, the "extracorporeal circulation circuit" as used herein means a component other than the blood purification device among the components of the blood purification system. In the blood purification system 1 of the first embodiment, the "extracorporeal circulation circuit" refers to a method in which the blood purification device 100 is removed from the components of the blood purification system 1. Specifically, the extracorporeal circulation circuit includes a plasma separator 10, an arterial side circuit 20 and a vein side circuit 30 connected to the plasma separator 10, a plasma component separator 40, and a plasma separator 10 and a plasma component separator 40. The first connection circuit 50; the circulation circuit 60 connected to the plasma component separator 40 and the first connection circuit 50; and the second connection circuit 70 connected to the plasma component separator 40 and the vein side circuit 30.

The plasma separator 10 is not described in detail. The membrane type plasma separator is a selective separation membrane that separates the inflowing blood into a blood cell component and a plasma component inside the cylindrical casing. The outer casing is provided with: an inflow portion 12 through which blood flows in; a first outflow portion 14 through which a liquid mainly containing a blood cell component is separated from blood separated by a selective separation membrane; and a selective separation membrane Mainly separated blood The second outflow portion 16 from which the liquid containing the plasma component flows out.

The arterial side circuit 20 is connected to the inflow portion 12 of the plasma separator 10. An air trap 22 and a rolling tube portion 24 are provided in the middle of the artery side circuit 20. Further, although not described in FIG. 1, an anticoagulant injection line for introducing an anticoagulant into the circuit is connected in the middle of the artery side circuit 20.

The vein side circuit 30 is connected to the first outflow portion 14 of the plasma separator 10. A gas trap 32 is provided in the middle of the vein side circuit 30. Further, although not shown in FIG. 1, a bubble detector is provided in the middle of the vein side circuit 30, and a pressure sensor is connected to the gas trap 32.

Although the plasma component separator 40 is not described in detail, the membrane type plasma component separator is disposed inside the cylindrical casing and is configured to separate the inflowing plasma component into a low molecular weight component and a high molecular weight component. Separation membrane. Among the low molecular weight components, for example, albumin or urea, creatinine, myoglobin, and the like are contained in a large amount, and among the high molecular weight components, for example, immunoglobulin (IgM or the like) or LDL (low-density lipoprotein) is contained in a large amount. Low density lipoprotein) cholesterol and the like. An inflow portion 42 into which a plasma component flows is provided on the outer casing; a first outflow portion 44 through which a liquid mainly containing a high molecular weight component is separated from a plasma component separated by a selective separation membrane; and by selective separation The plasma component separated by the membrane mainly contains the second outflow portion 46 from which the liquid of the low molecular weight component flows out.

The end of the first connecting circuit 50 is connected to the second outflow portion 16 of the plasma separator 10 and the inflow portion 42 of the plasma component separator 40, respectively. A gas trap 52 and a transfer portion 54 are provided in the middle of the first connection circuit 50. Further, although not shown in FIG. 1, a pressure sensor is connected to the air trap 52.

The end of the circulation circuit 60 is connected to the first outflow portion 44 of the plasma component separator 40 and the gas trap 52 of the first connection circuit 50, respectively. In the middle of the circulation loop 60, A turn portion 64 is provided.

The end of the second connecting circuit 70 is connected to the second outflow portion 46 of the plasma component separator 40 and the gas trap 32 of the vein side circuit 30, respectively.

As shown in FIGS. 1 and 2, the blood purification device 100 includes a device body 110, a blood pump 120 for transporting blood on the arterial side circuit 20 to the plasma separator 10, and a plasma pump 122 for The plasma component on the first connection circuit 50 is sent to the plasma component separator 40, and the circulation pump 124 is for discharging the liquid on the circulation circuit 60 (the liquid containing a high molecular weight component in a large amount) into the first connection circuit 50. The heat source 130 adjusts the temperature of the liquid flowing in the circulation circuit 60; the power supply unit 140 supplies power to each part in the apparatus body 110; and the input unit 142 receives various inputs from the operator. a display unit 144 that displays various information such as temperature information of blood flowing in the circuit or pressure information measured by a pressure sensor; a memory unit 146 that memorizes various information; and a main control unit 160 that collectively Each part in the blood purification apparatus 100 is controlled.

The blood pump 120, the plasma pump 122, and the circulation pump 124 are so-called roller pumps. Although the description of the illustration is omitted, the roller portion of the blood pump 120 can rotate (hold the tube portion 24) in contact with the tube portion 24 of the artery side circuit 20, and the liquid in the artery side circuit 20 can be (Blood) is transmitted in the intended direction. The function of the other pumps 122, 124 is also the same as in the case of the blood pump 120. The blood pump 120, the plasma pump 122, and the circulation pump 124 are attached to the apparatus body 110. The tube portion 24, the tube portion 54, and the tube portion 64 are attached to each of the blood pump 120, the plasma pump 122, and the circulation pump 124, and the plasma separator 10, the plasma component separator 40, and the like are attached. The constituent member is disposed at a predetermined position of the apparatus body 110, whereby the extracorporeal circuit is mounted on the apparatus body 110. Alternatively, the extracorporeal circuit can be removed from the device body 110 in the reverse order of the order in which the extracorporeal circuit is mounted on the device body 110.

The heat source unit 130 is omitted from the illustration, but it is a so-called dry warmer and is configured to liquidize the flow in the circulation circuit 60 by sandwiching a portion of the circulation circuit 60 from the heating plate. Warm up. A variable range of the operating temperature (for example, 36 ° C to 45 ° C) is set in advance on the heat source unit 130.

The input unit 142 is not illustrated, but it is configured such that the flow rate of each pump can be input, the operating temperature of the heat source 130, and the like.

The display unit 144 is not illustrated in the drawings, but is configured to visually display and output various calculation results of the main control unit 160.

The input unit 142 and the display unit 144 are not shown in the drawings, but they are disposed on the outer surface of the apparatus body 110. Furthermore, the input unit 142 and the display unit 144 may be configured as separate devices as an operation button and a screen, or may be, for example, a touch panel type display in which an input portion and a display portion are integrated.

The memory unit 146 is configured by a general-purpose memory such as an EEPROM (Electrically Erasable Programmable Read-Only Memory). In the memory unit 146, in addition to the performance data of the plasma separator 10 and the plasma component separator 40 used, the predetermined flow rate values of the pumps 120 to 124, the predetermined operating temperature of the heat source 130, and the operation are also stored. The range of temperature can vary.

In addition, the predetermined flow rate value of each of the pumps 120 to 124 is an initial setting value of the flow rates of the pumps 120 to 124 used when the flow rate value is not input to the input unit 142. Further, the predetermined operating temperature of the heat source unit 130 is an initial setting value of the operating temperature of the heat source unit 130 used when the operating temperature is not input to the input unit 142.

The main control unit 160 is configured by a central processing unit (CPU) or a circuit board on which a CPU is mounted. As shown in FIG. 2, the main control unit 160 can be divided into at least four functional blocks. As 4 function blocks, at least: The flow rate determining unit 170 determines the execution flow rate of each of the pumps 120 to 124 based on the flow rate value input to the input unit 142, and the pump control unit 172 executes the flow rate determined by the flow rate determining unit 170. The driving of each of the pumps 120 to 124 is controlled, and the operating temperature determining unit 180 determines the operating temperature of the heat source 130 based on the execution flow rate of the circulation pump 124 determined by the flow rate determining unit 170; and the heat source control unit 182. The heat applied to the liquid by the heat source 130 is controlled based on the operating temperature determined by the operating temperature determining unit 180. Hereinafter, the flow of processing performed by the main control unit 160 will be described with reference to the flowcharts shown in FIGS. 4 and 5.

The execution flow rate determining unit 170 refers to the execution flow rate determining program stored in the memory device (or the memory device (not shown) mounted in the device body 110) included in the main control unit 160, and inputs the input flow rate determining program to the input unit 142. In the case of the flow rate value (Yes in step S401), the flow rate value input to the input unit 142 is determined as the execution flow rate of each of the pumps 120 to 124 (step S402).

The pump control unit 172 refers to the pump control program stored in the memory device (or the memory device (not shown) mounted in the device body 110) of the main control unit 160, and the related execution flow information is determined. After the self-executing flow rate determining unit 170 transmits the pump control unit 172, the driving of each of the pumps 120 to 124 is controlled (step S403).

The operating temperature determining unit 180 determines the operating temperature of the heat source 130 by referring to the operating temperature determining program stored in the memory device (or the memory device (not shown) mounted in the device body 110) provided in the main control unit 160. . The information related to the execution flow rate determined by the execution flow rate determining unit 170 is also transmitted from the execution flow rate determining unit 170 to the operating temperature determining unit 180. Therefore, the operating temperature determining unit 180 determines the operating temperature of the heat source 130 based on the information on the execution flow rate of the circulation pump 124 transmitted from the execution flow rate determining unit 170 (step S501).

The heat source controller 182 controls the heat source control program stored in the memory device (or the memory device (not shown) mounted in the device body 110), and is controlled by the heat source 130. The heat of the liquid. After the information about the operating temperature determined by the operating temperature determining unit 180 is automatically transmitted to the heat source control unit 182, the heat source control unit 182 controls the heat applied to the liquid by the heat source 130 (step S502). .

When the operating temperature determined by the operating temperature determining unit 180 is higher than the predetermined operating temperature, the heat source control unit 182 increases the amount of heat per unit time applied from the heat source 130 to the circulation circuit 60. The operating temperature is set and the heat applied by the heat source 130 is controlled. On the other hand, when the operating temperature determined by the operating temperature determining unit 180 is lower than the predetermined operating temperature, the heat source control unit 182 makes the heat per unit time applied from the heat source 130 to the circulation circuit 60 smaller. The method sets the operating temperature and controls the amount of heat applied by the heat source 130.

Furthermore, the heat applied by the heat source unit 130 is controlled by the heat source controller 182 so as to be the operating temperature input to the input unit 142 by the operating temperature determining unit 180 before the operating temperature is determined.

When controlling the heat of the heat source 130, for example, the magnitude of the current flowing in the heat source 130 can be controlled, and the energization time of the heat source 130 or the length of the cycle thereof can also be controlled.

The operating temperature determining unit 180 refers to the "operating temperature determining program" that determines the operating temperature of the heat source 130 based on the execution flow rate of the circulation pump 124 determined by the execution flow rate determining unit 170, and refers to the change of the heat source 130 that is temporarily changed. The "temperature range change program" of the upper limit value or the lower limit value of the range is processed as described below.

That is, the temperature range changing program is determined by the operating temperature determining unit 180. When the determined operating temperature is expressed by, for example, a value higher than the allowable variable range as the operating temperature, the temperature range changing program is executed and the processing is performed to temporarily change the upper limit of the variable range of the heat source 130. . At this time, the upper limit value after the change is higher than the original upper limit value, and is a value equal to or higher than the operating temperature determined by the operating temperature determining unit 180. In this manner, the operating temperature determining unit 180 determines the amount of heat applied to the liquid by the heat source unit 130 within the variable range after the change.

Further, by changing the upper limit value by executing the temperature range changing program, for example, it is set such that the power of the blood purification device 100 is turned off (OFF) to be reset to the original upper limit value.

According to the blood purification apparatus 100 of the first embodiment configured as described above, the operation temperature determining unit 180 and the heat source control unit 182 are provided, and therefore, even if the control for changing the flow rate of the circulation pump 124 is performed, The changed flow rate is executed to control the amount of heat applied by the heat source 130. That is, even if the flow rate of the circulation pump 124 is changed, blood or the like can be adjusted to a desired temperature, and as a result, the desired therapeutic effect can be sufficiently obtained.

However, in the heat source device, in consideration of safety, there is a variable range that is allowed to be set as the operating temperature in advance so that the operating temperature does not exceed a predetermined range. Such a heat source device has a limitation in a temperature range that can be set as the operating temperature. Therefore, for example, when the operating temperature is to be set to a value other than the variable range based on the result of the comparison calculation by the arithmetic processing unit, the heat source device cannot respond to the request. As a result, it is conceivable that the operating temperature of the heat source cannot be set to a desired temperature.

In contrast, according to the blood purification device 100 of the first embodiment, the heat source control unit 182 can temporarily change the upper limit value or the lower limit value of the variable range by executing the temperature range change program. Therefore, even if a heat source having a variable range of the operating temperature is set in advance 130. The operating temperature of the heat source 130 can also be set to a desired temperature.

In the blood purification device 100 of the first embodiment, since the heat source device 130 is a warmer, it is particularly preferably used in the case of performing a blood purification therapy using a warmer such as a warming type recirculation method.

[Second Embodiment]

Fig. 3 is a block diagram showing an electrical configuration of the blood purification device 200 of the second embodiment.

In FIG. 3, the same members as those in FIG. 2 are denoted by the same reference numerals, and detailed description thereof will be omitted.

The blood purification device 200 of the second embodiment basically has the same configuration as the blood purification device 100 of the first embodiment, but the function of the execution flow rate determining unit 270 shown in Fig. 3 is different from that of the blood purification device 100 of the first embodiment. .

As a program to be executed by the execution flow rate determining unit 270, when the flow rate values of the pumps 120 to 124 are not input to the input unit 142 (NO in step S401 of FIG. 4), the predetermined value information stored in the memory unit 146 is stored. The reading program for reading the predetermined flow rate values of the pumps 120 to 124 is read (step S404), and the executed flow rate determining program for determining the predetermined flow rate value to be read is determined as the execution flow rate of each of the pumps 120 to 124 (step S405).

The blood purification device 200 of the second embodiment differs from the blood purification device 100 of the first embodiment in that the blood flow determining device 100 performs the processing executed by the flow rate determining unit. However, the blood purification device 100 of the first embodiment is similar to the blood purification device 100 of the first embodiment. Since the operating temperature determining unit 180 and the heat source control unit 182 are provided, blood or the like can be adjusted to a desired temperature even if the flow rate of the circulation pump 124 is changed, and as a result, the desired therapeutic effect can be sufficiently obtained.

The blood purification device 200 of the second embodiment is executed by the flow rate determining unit. The blood purification apparatus 100 of the first embodiment has the same configuration as the blood purification apparatus 100 of the first embodiment, and has the corresponding effects of the effects of the blood purification apparatus 100 of the first embodiment.

Although the blood purification device of the present invention has been described above based on the above-described embodiments, the present invention is not limited to the above-described embodiments, and various modifications may be made without departing from the scope of the invention. For example, the following modifications may be made.

(1) In the above-described embodiment, the blood purification system for performing the warming type recirculation method has been described as exemplifying that the heat source is disposed so as to adjust the temperature of the liquid in the circulation circuit. However, the present invention is not Limited to this. For example, in a blood purification system for performing Double Filtration Plasmapheresis (DFPP), the present invention can be applied even in the case of adjusting the temperature of a part of the extracorporeal circuit. Similarly, in the liquid feeding system for supplying liquid to the human body, the present invention can be applied even in the case where a part of the circuit is heated or cooled.

(2) In the above embodiment, the heat source has been described as a dry type warmer in which one part of the circulation circuit is heated by sandwiching the heating plate, but the present invention is not limited thereto. For example, it may be a type of dry warmer that is heated by inserting one of the circulation loops into the heating groove portion that is dug into an S-shape or the like in a plan view, or may be a heater for heating In the water tank, a type of wet warmer in which a part of the circulation circuit is arranged in a coil shape and heated. Further, in the above embodiment, the case where the heat source device is a warmer has been described. However, the present invention is not limited thereto, and may be a cooler. In this case, it is preferable to perform a blood purification therapy such as a plasma cooling filtration method or the like using a cooler. That is, when it is convenient to use any one of the warmer or the cooler as the heat source, the function of the heat source control unit is still to control the heat conducted between the heat source and the liquid.

(3) In the above-described embodiment, the case where the so-called roller pump is used has been described as an example of the pump. However, the present invention is not limited thereto, and other known liquid supply means such as a syringe pump may be used.

Here, the characteristics of the embodiment of the blood purification apparatus of the present invention described above are simply summarized and summarized in the following [1] to [6].

[1] A blood purification device (100) comprising: a device body (110) detachably attached to an extracorporeal circuit; at least one pump (120, 122, 124) for use in the extracorporeal circuit The liquid is transported internally; the heat source (130) warms or cools the liquid flowing in the extracorporeal circuit; and the main control unit (160) performs various controls; and the main control unit (160) has: The execution flow rate determining unit (170) determines the execution flow rate of the pump, and the pump control unit (172) controls the driving of the pump based on the execution flow rate of the pump determined by the execution flow rate determining unit (170). The operating temperature determining unit (180) determines the operating temperature of the heat source (130) based on the execution flow rate of the pump determined by the execution flow rate determining unit (170); and the heat source control unit (182) The heat conducted between the heat source (130) and the liquid is controlled based on the operating temperature of the heat source (130) determined by the operating temperature determining unit (180).

[2] The blood purification device according to [1] above, wherein the blood purification device (100) further includes an input unit (142) that can input a flow value for setting an execution flow rate of the pump. , The execution flow rate determining unit (170) determines the execution flow rate of the pump based on the flow rate value input to the input unit (142).

[3] The blood purification device according to [1] above, wherein the blood purification device (200) further includes a storage unit (146) that memorizes information on an execution flow rate of the pump, and the execution is performed. The flow rate determining unit (270) determines the execution flow rate of the pump based on the information on the execution flow rate stored in the storage unit (146).

[4] The blood purification device according to any one of the above [1] to [3] wherein the heat source device (130) is preliminarily set as the operating temperature. In the variable range, the operating temperature determining unit (180) temporarily changes the variable range when the operating temperature of the heat source (130) derived from the pump flow rate is deviated from the preset variable range The upper limit value or the lower limit value is determined within the above-described variable range after the change, and the operating temperature of the heat source device is determined.

[5] The blood purification device according to any one of the above [1] to [4] wherein the heat source device (130) is a warmer.

[6] The blood purification device according to any one of the above [1] to [4] wherein the heat source is a cooler.

The present invention has been described in detail with reference to the specific embodiments thereof. It is obvious to those skilled in the art that various changes or modifications may be made without departing from the spirit and scope of the invention.

The present application is based on Japanese Patent Application No. 2012-050416, filed on Jan.

(industrial availability)

According to the present invention, blood or the like can be adjusted to a desired temperature even if the flow rate of the pump is changed. As a result, it is effective in sufficiently obtaining the desired therapeutic effect, and thus it is useful in the field of blood purification devices.

100‧‧‧ blood purification device

110‧‧‧ device body

120‧‧‧ blood pump

122‧‧‧plasma pump

124‧‧‧Circulating pump

130‧‧‧heat source

140‧‧‧Power Supply Department

142‧‧‧ Input Department

144‧‧‧Display Department

146‧‧‧Memory Department

160‧‧‧Main Control Department

170‧‧‧Execution Flow Determination Department

172‧‧‧Pump Control Department

180‧‧‧Action Temperature Decision Department

182‧‧‧Hot source control department

Claims (5)

A blood purification device comprising: a device body for detachably attaching an extracorporeal circuit; at least one pump for delivering a liquid to the extracorporeal circuit; and a heat source for flowing to the extracorporeal circuit The liquid inside is heated or cooled; and the main control unit performs various controls; and the main control unit includes: an execution flow rate determining unit that determines an execution flow rate of the pump; and a pump control unit that performs the above The operation rate of the pump determined by the flow rate determining unit controls the driving of the pump, and the operating temperature determining unit determines the operating temperature of the heat source based on the execution flow rate of the pump determined by the execution flow rate determining unit. And a heat source control unit that controls heat conducted between the heat source and the liquid in accordance with an operating temperature of the heat source determined by the operating temperature determining unit; and the heat source is preset in advance The operating temperature determining unit is derived from the execution flow rate of the pump as the allowable range of the operating temperature When the operating temperature of the heat source device deviates from the preset variable range, the upper limit value or the lower limit value of the variable range is temporarily changed, and the operation of the heat source device is determined within the variable range after the change. temperature. The blood purification device according to claim 1, further comprising an input unit that can input a flow rate value for setting an execution flow rate of the pump, The execution flow rate determining unit determines the execution flow rate of the pump based on the flow rate value input to the input unit. The blood purification device according to claim 1, further comprising: a memory unit that stores information on an execution flow rate of the pump, wherein the execution flow rate determining unit performs the above-described execution in the memory unit Information about the flow rate to determine the flow rate of the above pump. The blood purification device according to any one of claims 1 to 3, wherein the heat source is a warmer. The blood purification device according to any one of claims 1 to 3, wherein the heat source is a cooler.