TWI538684B - Chinese herbal medicine composition with function of protecting eyes and manufacturing method thereof - Google Patents

Description

Medicinal material composition with eye protection function and manufacturing method thereof

The invention relates to a composition of a traditional Chinese medicine, in particular to a composition of a medicinal material having an eye-protecting function.

The main sensory functions of the human body include visual, auditory, olfactory, taste and proprioception. These functions are important bridges for human contact and communication with the outside world. Among them, vision can lead the human body to see foreign objects, read, write, drive, and go out. Activities, etc., are therefore one of the important sensory organs in contact with the external environment.

Common clinical diseases in ophthalmology include age-related macular degeneration (ARMD), night blindness, diabetic retinopathy, retinal detachment, glaucoma, etc., all of which are caused by optic nerve-related cell death. However, damage to the nerve structure is generally very difficult to recover. Therefore, for these patients with visual impairment, how to develop a treatment technique that improves or restores part of vision is an urgent task.

Among the above-mentioned clinical diseases common to ophthalmology, one of the important causes of visual diseases is oxidative stress. Oxidative stress destroys retinal ganglion cells, retinal pigment epithelial cells, and vascular endothelial cells of the eyeball. Although the body has an antioxidant system and a free radical scavenger (free radical) Scavenger and other systems with protective functions, but the constancy between the generation and elimination of reactive oxygen species may be disturbed by lack of nutrition, hypoxia, ischemia, changes in the metabolic system, or changes in the antioxidant system, causing cell membranes. Lipid peroxidation and oxidation of intracellular macromolecules, even leading to cell death. Therefore, how to prevent free radicals generated by oxidative stress and reduce damage to cells and tissues in the eyeball is a hot topic of research.

Among them, age-related macular degeneration is an age-related, photoreceptor cell in the macula of the retina and a progressive disease in which the retinal pigment epithelial cells in the outer layer are gradually degraded by oxidative stress, due to the high proportion of cone cells in the macula. And its concave structure allows light to directly stimulate photoreceptor cells, so the oxidative activity is more severe, so patients with age-related macular degeneration are likely to cause damage to central vision, and severe cases may even cause blindness.

In the eighteenth century, lutein was found in humans and primates, and in 1945 it was confirmed that there was a large amount of lutein in the retina. Therefore, it is clinically considered that lutein may play an important role in maintaining the normal function of the retina, and because lutein has a strong antioxidant capacity, it seems to suggest that lutein plays an antioxidant role in protecting the retina. .

In addition, there have been more and more researches on the development and mechanism of action of Chinese herbal medicines. In addition, the use of Chinese herbal medicines in visual health care has fewer side effects than the active ingredients, so more and more health foods are used. Add Chinese herbal extracts to increase vision and antioxidant capacity. Moreover, in addition to ancient records, the clinical use of Chinese herbal medicines can also be used to find new active ingredients by extraction, separation and purification combined with screening of activity evaluation.

However, although some Chinese herbal medicines have been found to have health care Vision and anti-oxidation effects, but there is no real test data to confirm that Chinese herbal medicine can improve vision degradation. Therefore, finding the best Chinese herbal medicine composition and its manufacturing method is an important issue for researchers in the field of Chinese herbal health food.

In view of the above-mentioned problems of the prior art, it is an object of the present invention to provide a medicinal composition having an eye-protecting function to provide lutein having a health care function.

According to another object of the present invention, a composition of a medicinal material having an eye-protecting function is proposed to prevent the human retina from being damaged by free radicals.

According to still another object of the present invention, a composition of a medicinal material having an eye-protecting function is proposed to improve the deterioration of human vision.

According to still another object of the present invention, a method for producing a medicinal material composition having an eye-protecting function is provided to obtain a medicinal material composition having health care vision and improving human retinal degeneration.

In order to achieve the above object, the present invention provides a medicinal material composition having an eye protection function, comprising at least a mixture of Chinese medicinal materials, and the Chinese medicinal material mixture comprises at least 70% to 30% by weight of the compositae, 45% by weight. Up to 15% by weight, 20% to 5% by weight of blueberries, 20% to 5% by weight of cassia, and 10% to 1% by weight of Rhodiola. Preferably, the weight percentage of Compositae is 45%, the weight percentage of mash is 30%, the weight percentage of blueberry is 10%, the weight percentage of cassia seed is 10%, and the weight percentage of Rhodiola is 5%.

In addition, the present invention further provides a method for producing a medicinal material composition having an eye protection function, comprising at least the following steps: providing a mixture of Chinese medicinal materials, wherein The Chinese medicinal material mixture comprises at least a compositae, medlar, blueberry, cassia seed and Rhodiola; an extraction step is performed, the Chinese medicinal material mixture is extracted by the extract to obtain a mixed extract; and a filtering step is performed to filter the mixed extract to obtain an extraction a filtrate; a concentration step for concentrating the extraction filtrate to obtain an extract extract; and a spray-drying process for drying the extract extract to obtain a powdery intermediate composition. Among them, in the mixture of Chinese herbal medicines, the weight percentage of Compositae is 45%, the weight percentage of sputum is 30%, the weight percentage of blueberry is 10%, the weight percentage of cassia seed is 10%, and the weight percentage of Rhodiola is 5 %. In addition, the extract consisted of 70% ethanol and 30% hexane, and the extract weight was 16 times the weight of the Chinese herbal mixture.

In the method for producing a medicinal composition having an eye-protecting function of the present invention, the extraction step is a reflux extraction step, wherein the extraction temperature of the reflux extraction step is 100 to 70 ° C and the extraction time is 2 to 4 hours. The concentration step is to concentrate the extraction filtrate by a pressure reduction step. In addition, the drying step further comprises adding an excipient, wherein the extract extract comprises 25% by weight of the composition of the Chinese herbal medicine, and the excipient comprises 75% by weight of the composition of the Chinese herbal medicine.

According to the present invention, the medicinal composition having the eye protection function according to the present invention may have one or more of the following advantages:

(1) The medicinal material composition having the eye-protecting function of the present invention can provide lutein having a health-care function by a medicinal material composition in a specific ratio.

(2) The medicinal material composition having the eye-protecting function of the present invention can prevent the human retina from being damaged by free radicals by the lutein in the composition of the Chinese medicinal material.

(3) The composition of the medicinal material having the function of protecting the eye of the present invention can be changed Good degeneration of the human retina.

(4) The method for producing a medicinal material composition having an eye-protecting function according to the present invention, which can produce a medicinal material composition having a health care vision and a function of improving human retinal degeneration.

S10‧‧‧Providing a mixture of Chinese herbal medicines

S20‧‧‧Extraction step

S30‧‧‧Filter step

S40‧‧‧ Concentration step

S50‧‧‧ Spray drying step

Fig. 1 is a flow chart showing a method for producing a composition of a medicinal material having an eye-protecting function according to the present invention.

Fig. 2 is a graph showing the statistical analysis of a wave obtained by retinal electric wave measurement in five groups of animals.

Fig. 3 is a graph showing the statistical analysis of b-waves obtained by retinal electric wave measurement in five groups of animals.

Fig. 4 is a graph showing the degree of visual acuity recovery obtained by statistical analysis of a wave obtained by retinal electric wave measurement of the present invention and a blank group.

Fig. 5 is a graph showing the degree of visual recovery of the b-wave obtained by the retinal electric wave measurement by the present invention and the blank group.

The medicinal composition having the eye-protecting function of the present invention at least comprises a mixture of medicinal materials containing compositae, medlar, blueberry, cassia seed and Rhodiola. In this Chinese herbal medicine mixture, the proportion of the components of each Chinese herbal medicine may be, for example, 70% to 30% by weight of the Compositae, 45% to 15% by weight, and 20% to 5% by weight of the blueberry. Cassia of 20% to 5% by weight and Rhodiola by weight of 10% to 1%. Preferably, the weight percentage of the compositae can be, for example, 45%, the weight percentage of sputum can be, for example, 30%, the weight percentage of the blueberry can be, for example, 10%, and the weight percentage of cassia can be, for example, 10%, the weight percentage of Rhodiola can be, for example, 5%. However, the composition ratio of each of the above-mentioned Chinese herbal medicines is not intended to limit the present invention, and any composition of the medicinal materials which uses the same Chinese medicinal ingredients and has a health care function is the scope of protection claimed in the present invention.

In the medicinal composition having the eye-protecting function of the present invention, the Compositae may be, for example, chamomile (also known as chamomile), chrysanthemum or marigold. Compositae contain Jerusalem artichoke, amino acids, flavonoids and a variety of vitamins and trace elements. Chinese medicine believes that the Compositae plants have eyesight, retreat liver fire, treat insomnia, lower blood pressure, and enhance vitality and refreshment. Enhance memory and lower cholesterol. In addition, scientists have found antioxidants and some elements that inhibit microbial growth in chrysanthemum oil. This shows that the reference to chamomile tea has a long-term health effect.

Lycium, as recorded in Li Shizhen's "Compendium of Materia Medica" in the Ming Dynasty; "Spring picking leaves, famous Tiancao grass; Xia Caihua, famous long grass; autumn picking, name scorpion; winter root, famous land "Bone skin." As the ancient medicine book "Materia Medica" contains: "枸杞 can make the gas can be filled, the blood can be supplemented, the yang can be born, the yin can be long, the fire can be lowered, the rheumatism can go, there is a perfect use of 焉Therefore, it is often used as a traditional Chinese medicine. It can nourish the liver and kidney, benefit the essence and clear eyesight, and treat dizziness, dizziness, tears, and kidney deficiency.

Blueberry, also known as blueberry, is one of the ingredients of many dim sum and delicacies. It is often used in desserts such as jelly, jam, ice cream and pie. Blueberries are not only rich in vitamin A, vitamin C, vitamin E, carotenoids, potassium and zinc, but also contain anthocyanins and antioxidants in blueberries, which can help the health of the retina and reduce the chance of cancer. In addition, at the 2004 International Longevity Conference, research scholars pointed out that some specific compounds in blueberries have a strong influence on the inhibition of brain degeneration diseases such as Alzheimer's disease. Researchers at Rutgers University in the United States have also shown that blueberries may prevent urinary tract infections.

Cassia is the seed of Senna obtusifolia. It is a commonly used traditional Chinese medicine, and the seeds are used as medicine. It has the functions of clearing the liver and improving eyesight and laxative. Indications for hypertension, headache, dizziness, acute conjunctivitis, corneal ulcers, glaucoma, hemorrhoids and other symptoms. With its leaf tea, long-term drinking of middle-aged and elderly people can make blood pressure normal and smooth stool.

Rhodiola is a kind of herbal medicine, also known as Tibetan god grass. In the "Compendium of Materia Medica" and "Shen Nong's Herbal Classic", there are records of Rhodiola: life-saving in response to the sky, non-toxic, multi-service, long service does not hurt people, It is a medicine for light body and good fortune. Rhodiola is the root and rhizome of Sedum, which is sweet, bitter and astringent. It is red because it contains anthocyanidin. The flavonoids in the ingredients can immediately activate the mitochondria and recreate energy. The various phenolic compounds contained in the plant are strong antioxidants, in addition to significantly improving the body's tolerance to hypoxia, and can promote the body's adaptation to anoxic environment and delay the occurrence and development of fatigue.

Please refer to FIG. 1 , which is a flow chart of a method for manufacturing a composition of a medicinal material having an eye protection function according to the present invention. As shown in Fig. 1, the method for producing a medicinal material composition having an eye-protecting function according to the present invention comprises at least the steps of: providing a mixture of Chinese herbal medicines S10, performing an extraction step S20, performing a filtration step S30, performing a concentration step S40, and performing a spraying Drying step S50. Wherein, the mixture of Chinese herbal medicines comprises at least 70% to 30% by weight of Compositae, 45% to 15% by weight of sputum, 20% to 5% by weight of blueberries, and 20% to 5% by weight. Cassia and Rhodiola with a weight percentage of 10% to 1%. Preferably, the weight percentage of the Compositae can be, for example, 45%, the weight percentage of the cockroach can be, for example, 30%, the weight percentage of the blueberry can be, for example, 10%, and the weight percentage of the cassia seed can be, for example, 10%, Rhodiola The weight percentage can be, for example, 5%. (The following description uses the chamomile as an example. However, the compositae used in the present invention is not limited to chamomile, and the user may select chrysanthemum or calendula according to actual needs).

The manufacturing process of the method for producing the medicinal material composition having the eye-protecting function of the present invention is as follows: First, the Chinese medicinal material mixture S10 is provided, and the Chinese medicinal materials in the above-mentioned Chinese medicinal material mixture are separately broken (the purpose of breaking the Chinese medicinal material) In order to make the Chinese herbal medicine sample evenly). The mixing step S20 is carried out by mixing the medicinal material mixture and the extract in a weight ratio of 1:16 to obtain a mixed extract, wherein the extract may be, for example, an organic solvent composed of 70% ethanol and 30% hexane, and the extraction step may be, for example, It is a reflux extraction step. The extraction temperature of the reflux extraction step may be, for example, 100 to 70 ° C and the extraction time may be, for example, 2 to 4 hours. Preferably, the extraction temperature of the reflux extraction step is 90 ° C, and the extraction time is 3 hours. After the above extraction step, the mixed extract is subjected to a filtration step S30 while hot to remove impurities in the mixed extract and obtain an extract filtrate.

Next, the extraction filtrate is subjected to a concentration step S40. Wherein, the concentration step may be performed by concentrating the extraction filtrate by a depressurization step to remove the organic solvent in the extraction filtrate, thereby obtaining an extract extract. Finally, the extracting extract is dried by a spray drying step S50 to obtain a powdery intermediate medicinal composition. Wherein, in the spray drying step, a pharmaceutically acceptable excipient may be further added, wherein the weight percentage of the extract of the Chinese herbal medicine composition may be, for example, 25%, and the excipients may be, for example, the weight percentage of the composition of the Chinese herbal medicine, for example. It is 75%, but is not limited to this. Further, the excipient may be composed, for example, of starch and crystalline cellulose.

(1) In order to confirm the extraction step S20 of the present invention using an extract composed of 70% ethanol and 30% hexane, it is effective to improve the extraction rate and chlorophyll content of the composition of the medicinal material of the present invention, the following description The procedure for the manufacture of Chinese herbal medicine compositions using four different extracts (water, alcohol, tetrahydrofuran and 70% ethanol + 30% hexane):

a. Chamomile, medlar, blueberry, cassia seed and Rhodiola After the Chinese herbal medicine is broken to make the medicine sample evenly, the four kinds of extracts with 16 times the weight of the medicine are subjected to reflux extraction. The above four kinds of extracts are respectively water; 95% alcohol; 100% tetrahydrofuran (Tetrahydrofuran, THF) ); and 70% ethanol + 30% hexane.

b. The reflux extraction set temperature was 90 ° C, the extraction time was 3 hours, and after 3 hours of extraction, it was filtered while hot.

c. The extract filtrate was concentrated to dryness under a reduced pressure concentrator.

d. After concentration and drying, the concentrated bottles containing the extract were weighed together and the extraction rate was calculated.

e. The extract was quantified to 20 ml (10 ml 95% alcohol + 8 ml THF + 2 ml Ro water), completely dissolved as a stock and stored in a refrigerator at 4 °C.

f. The stock was diluted 2 times with THF as a high performance liquid chromatography (HPLC) test sample, and 10 μl was taken for HPLC to identify lutein content.

g. The extraction rate of the obtained Chinese herbal medicine composition and its chlorophyll concentration are shown in the following Table 1. The results show that the Chinese herbal medicine composition is extracted with 70% ethanol + 30% hexane, which not only achieves a higher extraction rate but mainly protects the eyes. The content of chlorophyll components with efficacy is also significantly higher than other extraction methods.

(b) In order to confirm that the medicinal composition having the eye-protecting function of the present invention can effectively improve the visual deterioration of the user, in the evaluation test of the present invention, the electroretinogram of the rat is measured by electroretinography (electroretinography, ERG) to assess the visual function of the rat. The retinal radiography is the most important and sensitive technique for examining the retinal function of animals. It is the standard retinal function test method of the World Animal Ophthalmology Hospital.

In addition, in the evaluation test of the present invention, in addition to the timing measurement of the retinal radiometer to assess the recovery of vision, the values of GOT, GPT, BUN and γ-GT in the animal are also examined by blood sampling to evaluate the present. In the invention, the composition of the medicinal material has no effect on the liver and kidney of the animal.

The procedure of the visual acuity evaluation test of the present invention is as follows: First, experimental rats weighing 300 to 400 g are divided into five groups, the first group is a blank group (normal feeding and drinking only); the second group is a control group A ( The group of animals fed chamomile extract); the third group was control group B (animal group fed with cockroach extract); the fourth group was control group C (animal group fed with blueberry extract and cassia extract); and the present invention (An animal group fed with the medicinal composition of the present invention). Then, the above five groups of animals were subjected to a 12-hour light/12-hour dark light cycle in a fixed-temperature animal room to simulate the daily exposure time of normal animals, and to provide sufficient drinking water and feed. Before feeding the medicinal composition of the present invention, all five groups of animals were exposed to light for one week (light cycle 12 hours light / 12 hours dark, wherein the intensity of light was 10000 lux (Lux, lumens per square meter)) Rats were induced to degenerate the retina of the rat. Next, the researchers fed the control group A-C and the present invention continuously. Eat the above-mentioned Chinese herbal medicines, and regularly measure the retinal radiography and liver and kidney function tests of five groups of animals. Among them, the feeding method is feeding through a tube at a fixed time every day, and the feeding amount is 104 mg/kg/day (corresponding to an adult oral dose of 1000 mg/day).

The measurement of the retinal radiogram is as follows: First, after anesthetizing the rat with 50 mg/kg zoletil, the small animal corneal electrode is placed on the conjunctiva of the rat's eye, and the reference electrode is attached to the ear. After recording for four weeks with a retinal wave meter (AcriVet, Germany), the recorded results were analyzed by statistical analysis for the visual protection ability of the composition of the medicinal material of the present invention. Among them, the statistical analysis method is K-Kal-Wallis Test. Since the use of a retinal radiometer to observe animal vision is a non-invasive diagnostic method, the purpose of continuously observing the health of the mouse can be achieved without sacrificing the mouse.

The retinal radiography recorded by the retinal radiometer may include a-wave and b-wave. The a wave represents the action potential generated when the photoreceptor receives the light stimulus, and the b wave represents the action potential when the action potential is transmitted to the ganglion cell and the message is transmitted to the brain.

The above five groups of animals were continuously fed for four weeks and the retinal wave measurements were performed at regular intervals. The statistical analysis of the retinal radiograms obtained after the records was obtained, and the following figures 2 and 3 were obtained. Figure 2 is a statistical analysis of the a-waves obtained by retinal radio wave measurements in five groups of animals, and Figure 3 is a statistical analysis of b-waves obtained from retinal wave measurements in five groups of animals. Data map.

As shown in Fig. 2 and Fig. 3, after one week of light induction in rats (not yet fed the composition of the medicinal material of the present invention), the visual a wave of the rat was reduced to about 10 to 25% before light induction, and the rat The visual b-wave is reduced to about 30 to 50% before light induction. However, after continuously feeding the composition of the medicinal material of the present invention for four weeks, it can be seen from Fig. 2 that The visual a wave of the rat returned to about 60% before the light induction after 3 weeks of feeding, while the visual a wave of the blank group only returned to about 20% before the light induction. In addition, as can be seen from Fig. 3, the visual b wave of the rat can return to about 90% before the light induction after 3 weeks of feeding, while the visual b wave of the blank group can only return to about 50 before the light induction. %. In addition, as shown in Fig. 2 and Fig. 3, the effect of improving the visual acuity of the present invention is indeed superior to that of the control group AC. The results of the visual acuity evaluation test show that the composition of the medicinal material of the present invention does have an improvement for vision. Unpredictable effects.

Please continue to see Figures 4 and 5. Figure 4 is a data plot of the degree of visual recovery obtained by statistical analysis of the a-wave obtained by retinal radio wave measurement in the present invention and the blank group, and Figure 5 is the measurement of the retinal wave by the present invention and the blank group. B-wave data obtained by statistical analysis of the degree of visual recovery.

As shown in Fig. 4, comparing the blank group and the degree of visual recovery of the composition of the medicinal material of the present invention, it can be found that the rat of the Chinese medicinal composition of the present invention is fed one week after the composition of the medicinal material of the present invention is fed. The degree of visual recovery was approximately 20%, while the visual recovery of the blank group was only approximately 13%. Further, after feeding the medicinal composition of the present invention for three weeks, the degree of visual recovery of the rats fed the medicinal composition of the present invention was as high as about 35%, and the degree of visual recovery of the blank group was only about 10%.

Next, the degree of visual recovery of the b-wave measurement by the electroretinogram is compared. As shown in Fig. 5, it can be found that the vision recovery of the rat fed the composition of the medicinal material of the present invention after one week of feeding the medicinal composition of the present invention is found. The degree is about 13%, and the visual recovery of the blank group is only about 5%. After feeding the medicinal composition of the present invention for three weeks, the degree of visual recovery of the rats fed the medicinal composition of the present invention was as high as 38%, and the degree of visual recovery of the blank group was only about 10%. Further, as shown in Fig. 5, after feeding the composition of the medicinal material of the present invention, it is fed to the present invention. The degree of visual recovery of the medicinal composition of the rat can be as high as 45%, and it can be proved that the medicinal composition of the present invention can effectively restore the vision of the rat with retinal damage and has the effect of continuous visual recovery.

In addition, in the course of performing the above-described retinal electric wave measurement, the applicant also performed blood sampling on the two groups of rats to evaluate the influence of the composition of the medicinal material of the present invention on liver and kidney function. The method of measuring liver and kidney function is to measure 2 ml of blood in rats to detect the contents of GOT, GPT, γ-GT and BUN in blood. The detection results are shown in the following table:

cccGOT, GPT and γ-GT are the most common liver function tests, and the most important enzymes in liver cells. They are essential enzymes in the metabolism of carbohydrates and proteins. GOT (glutamate oxaloacetate transaminase, glutamic acid transamination), or PT to ammonia, AST. GPT (glutamate pyruvate transaminase, serum acetone transaminase), or OT transamination, ALT. γ-GT is a cell-binding glycoprotein, generally called an enzyme protein. Although it is abundantly present in the cell membrane of the renal urinary tract, most of the γ-GT in serum comes from the liver.

BUN (Blood Urea Nitrogen, urea nitrogen) is a protein that is metabolized by the liver. Waste from white matter is filtered by the kidneys. When the kidney is damaged or kidney dysfunction, the kidney elimination function may be reduced or completely lost, resulting in an increase in BUN. Too high a BUN can be toxic to the body and endanger the organs of the animal.

In the above table, the normal mouse is a rat which is not photoinduced and is not fed with the composition of the medicinal material of the present invention, and the blank group is a rat which is only light-induced but not fed with the composition of the medicinal material of the present invention, the present invention group That is, a rat that performs light induction and feeds the composition of the medicinal material of the present invention. As can be seen from the above table, the GOT, GPT, γ-GT and BUN contents of the rats of the present invention group and the blank group are similar, and compared with the normal values of the literature, the rats fed the Chinese medicinal composition of the present invention have The contents of GOT, GPT, γ-GT and BUN all fall within the range of normal values, indicating that the composition of the medicinal material of the present invention does not affect the liver and kidney function of the animal.

In summary, from the above-mentioned measurement of the retinal radiography and the degree of visual recovery, it is known that after continuous feeding of the composition of the medicinal material of the invention for four weeks, the visual acuity of the rat has a significant improvement effect after 3 and 4 weeks of feeding, and It can be seen from the above-mentioned liver and kidney function test that the composition of the medicinal material of the present invention does not destroy the liver and kidney function of the animal.

The above is intended to be illustrative only and not limiting. Any equivalent modifications or alterations to the spirit and scope of the invention are intended to be included in the scope of the appended claims.

S10‧‧‧Providing a mixture of Chinese herbal medicines

S20‧‧‧Extraction step

S30‧‧‧Filter step

S40‧‧‧ Concentration step

S50‧‧‧ Spray drying step

Claims (9)

A medicinal composition having an eye-protecting function, which is prepared by a method comprising the steps of: providing a mixture of Chinese medicinal materials, the Chinese medicinal material mixture being from 70% to 30% by weight of the compositae Plant, weight percentage of 45% to 15% by weight, weight percentage of 20% to 5% of one blueberry, weight percentage of 20% to 5% of one cassia, and weight percentage of 10% to 1% of one red Composition of the sky; performing an extraction step of extracting the mixture of the Chinese herbal medicine by an extract consisting of 70% ethanol and 30% hexane to obtain a mixed extract; and performing a filtration step, thereby obtaining the traditional Chinese medicine Material composition. The medicinal composition having an eye protection function according to claim 1, wherein in the method, a concentration step may be further performed after the filtering step. The medicinal composition having an ocular function as described in claim 2, wherein in the method, a spray drying step may be further performed after the concentrating step. The medicinal composition having an eye protection function according to claim 1, wherein in the method, the weight percentage of the compositae is 45%, the weight percentage of the cockroach is 30%, and the weight of the blueberry The percentage is 10%, the weight percentage of the cassia seed is 10%, and the weight percentage of the Rhodiola is 5%. The invention relates to a method for manufacturing a medicinal material composition with eye protection function, comprising at least the following steps: providing a mixture of Chinese herbal medicines, the Chinese medicinal material mixture is from 70% to 30% by weight of a compositae, 45% by weight Up to 15% 杞, a percentage by weight of 20% to 5% of blueberries, 20% to 5% by weight of cassia, and 10% to 1% by weight of Rhodiola; performing an extraction step by one Extracting the mixture of Chinese herbal medicines with an extract consisting of 70% ethanol and 30% hexane to obtain a mixed extract; performing a filtration step for filtering the mixed extract to obtain an extraction filtrate; performing a concentration step, using The extracting filtrate is concentrated to obtain an extracting extract; and a spray drying step is performed to dry the extracting extract to obtain a powdered composition of the Chinese herbal medicine. The method for producing a medicinal composition having an eye protection function according to claim 5, wherein the weight percentage of the compositae is 45%, the weight percentage of the cockroach is 30%, and the weight percentage of the blueberry is 10%, the weight percentage of the cassia seed is 10%, and the weight percentage of the Rhodiola rosea is 5%. The method for producing a medicinal composition having an eye protection function according to claim 5, wherein the extraction step is a reflux extraction step. The method for producing a medicinal composition having an eye protection function according to claim 5, wherein the extract has a weight of 16 times the weight of the mixture of the Chinese medicinal materials. The method for producing a medicinal material composition having an eye protection function according to claim 5, wherein the drying step further comprises adding an excipient, wherein the extracting extract comprises the weight percentage of the composition of the Chinese medicinal material 25%, the excipient accounted for 75% by weight of the composition of the Chinese herbal medicine.