TWI519843B - Ophthalmic lens and method for the slowing of myopia progression, and method of designing contact lens thereof, and article used to perform the method thereof - Google Patents

Description

Ophthalmic lenses and methods for slowing the development of myopia, methods for designing contact lenses thereof, and objects for performing the methods thereof

The present invention is directed to designs and methods for preventing, suppressing or slowing the progression of myopia.

Myopia (also known as short-sightedness) is a type of refractive situation in which the total focus of the eye is too high or too strong, causing the light from the distal object to focus on the retina. The observer thus perceives that the far-end object is a blurred image, and the amount of blur is related to the severity of myopia. These situations are often seen in childhood and are perceived at school age. Until the adolescence, the development or increase of the severity of myopia is common.

U.S. Patent No. 6,045,578, which is incorporated herein by reference, discloses the use of the coaxial longitudinal spherical aberration (LSA) method in an attempt to stop the development of myopia. This design does not focus on the specific wavefront/refractive force characteristics of the eye in the case, or the group average of the feature, or the change in pupil size at close range.

U.S. Patent No. 7,025,460, the disclosure of which is incorporated herein by reference to the entire entire entire entire entire entire entire entire entire entire--- The mathematics used behind this method is the "expansion conic curve", in which the simple conic equation is added with odd-order polynomials. The processing of these conic curves and polynomials allows the shape of the pre-designed contact lens to produce the desired amount of field curvature. This method focuses on off-axis design. Coaxial lens optics have not been proposed. Regarding the close-range work, changes in pupil size and wavefront have not been proposed.

U.S. Patent Application Serial Nos. 2003/0058404 and 2008/0309882 disclose a method of measuring the wavefront of the eye and correcting the case to slow the progression of myopia. It does not include wavefronts that measure near-stimulus distances, and it is not recommended to consider differences between wavefronts measured by distal and proximal stimuli. The size of the pupil during close-up work is not the level considered in the design process.

European Patent No. 1853961 discloses the measurement of wavefronts before and after work at close range. The change in wavefront aberrations is then corrected with custom contact lenses. It only focuses on the wavefront before and after work, and does not involve the difference between the wavefronts measured for the distal and proximal stimuli. During the design process, pupil changes in close-range work are not considered. It does not involve the use of group or ethnic data to control eye growth design.

There is still a need for a more complete approach to halting or slowing the development of myopia. This manual focuses on this.

One aspect of the present invention is a method and resulting design that utilizes wavefront data from the eye to create an ophthalmic lens that is useful for controlling or slowing myopia development. Ophthalmic lenses include, for example, contact lenses, intraocular lenses, corneal implant lenses, and corneal cap lenses. In addition, a pattern formed by a corneal refractive surgery such as laser in situ keratoplasty (LASIK) is included.

Another aspect of the present invention is a method and design for making a lens to slow myopia for use by a patient and having an ability to adjust.

Yet another aspect of the present invention is a design for producing an ophthalmic lens design in accordance with the method of the present invention comprising a convex surface having a central optical zone surrounded by a peripheral zone which is then surrounded by the edge zone and supported The concave surface of the wearer's eye; the lens power at any position in the optical zone is described by the sum of the wavefront derived power derived from the distal apex of the axial apex plus the correction amount, wherein The correction amount is the difference in power derived from the average wavefront of the distal and proximal ends of a single, partial complex or complex position x), and the power difference derived from the wavefront of the proximal and distal ends of the vertices. Derived; lenses made with these designs can be used to control or slow the progression of myopia.

Another aspect of the invention is a method of producing an ophthalmic lens design, the steps comprising: acquiring wavefront data, converting the wavefront data to a radial power map, and generating a lens power profile (lens power profile) ).

Yet another aspect of the present invention is to consider the wavefront data of the overall population.

Yet another aspect of the present invention is to consider the wavefront data of the subgroup.

Yet another aspect of the present invention is to consider the wavefront data of a case.

In yet another aspect of the invention, the wavefront data is an average of a plurality of wavefront files.

In yet another aspect of the invention, the lens power profile of the design is averaged over all meridians of the rotationally symmetric form.

In yet another aspect of the invention, the lens power profile of the design is calculated based on the inversion of the proximal power profile.

In yet another aspect of the invention, the lens power profile of the design is calculated to offset the negative aberration of the near-end power profile.

In yet another aspect of the invention, the lens power profile of the design is calculated by adding a distance to the proximal power profile.

In yet another aspect of the invention, the lens power profile of the design is calculated by adding a multiple of the distance to the proximal power profile.

In yet another aspect of the invention, the lens power profile of the design is calculated by adding a portion of the distance to the proximal power profile.

In yet another aspect of the invention, the lens design method for slowing the progression of myopia is encoded as instructions, such as machine instructions, and is designed as a computer program.

In another aspect of the invention, the object is a lens design execution instruction comprising a method for slowing the progression of myopia; the method comprising converting a wavefront data representative of an eye feature to a radial power map, generating a lens power profile, and Using the power profile to create a lens design comprising a convex surface having a central optical zone surrounded by a peripheral zone, the peripheral zone being surrounded by the edge zone, and a concave surface supported on the wearer's eye; The lens power at any position in the region is described by the sum of the average far-end wavefront derived power of the axial apex plus a correction amount, wherein the correction is performed by a single part. The difference between the power of the complex wavefront derived at the far end and the near end of each of the complex positions (x), and the power difference derived from the wavefront derived at the proximal and distal ends of the vertex are derived.

The method of the present invention involves the use of wavefront data to design and manufacture contact lenses for the treatment, alleviation, and in some cases, the prevention of myopia progression. Ocular wavefront data, including two levels of distal and proximal stimulation, are collected from the patient by a wavefront sensor, such as COAS (Wavefront Sciences Inc, Albuquerque N.M.). The wavefront data is generally represented by a Zernike polynomial coefficient, but it can also be specified by a set of wavefront coordinates in a Cartesian coordinate or polar coordinate. A preferred system for indicating Zernike coefficients has been described in the OSA method of the American National Standards Institute (ANSI) Z80.28.

The method of designing a lens can be to design a customized lens for an individual subject, or a general design for a group or subgroup. The method can be used to generate a rotationally symmetric design in which all of the optical zone meridians are the same, or non-rotationally symmetric, with any meridian being a unique meridian based on the results of the wavefront analysis. In some embodiments, it is known that the change in pupil size due to conditioning or brightness is considered.

A preferred method of producing an ophthalmic lens design is based in part on eye wavefront data and includes the following steps:

1. Eye wavefront data for the distal and proximal stimulation levels are collected from the patient using a wavefront sensor;

2. Convert each wavefront to a refractive power map by estimating the radial slope in the z-axis direction, which is defined as the axis from front to back, for example along the visual axis through the center of the pupil.

3. Calculate the axial focal length (ie, the radial "normal" and z-axis intersection) and the converted focal length as the optical power value (Figure 1).

In another embodiment of the method, the refractive power map is calculated by using the Zernike refractive power polynomial described below, and the resulting set of wavefront Zernike coefficients is calculated Ψ _j (ρ, θ) (see the attached file) Iskander et al., 2007).

Its c _j is the wavefront Zernike polynomial coefficient r _max corresponding to the pupil radius.

Take

And

For pupil size in the eye, it can also be estimated directly from the wavefront or through independent pupil measurements (eg using a pupil meter). If the measurement of the pupil does not involve the wavefront, the patient should be gaze at the distant target and the near target under similar illumination conditions, under the same level of adjustment stimulation as the measurement of the wavefront (eg 0 D and 3 D to adjust the stimulation level) ), take measurements. In order to obtain a wavefront map with sufficient diameter, it is preferred to measure the wavefront under medium to low brightness conditions. The distal and proximal wavefronts should be measured under the same brightness conditions, such as less than or equal to 50 candles per square meter.

Ophthalmic lenses made in accordance with the present invention have the following components and features:

a) having a convex surface of the central optical zone, surrounded by a peripheral zone, which is surrounded by an edge zone and a concave surface supported on the patient's eye;

b) The lens power at any position in the optical zone is described by the sum of the wavefront derived power derived from the average distal wavefront of the axial apex plus the correction amount, where the correction is determined by Single, partial complex or complex, the difference in power derived from the average wavefront at the distal and proximal ends of each position (x), and the difference in power derived from the wavefront at the near and far ends of the apex; These designed lenses are used to control or slow the progression of myopia.

The data file will be screened for analysis of the wavefront Zernike coefficient, pupil size and refractive power map to confirm its trend in wavefront dynamics and to remove outliers or invalid data (eg using wavefronts) File management software).

If complex wavefront data has been collected (in preferred cases), the refractive power map can be averaged to reduce random errors and variability due to factors such as adjusting for fretting.

The next step in the method produces an average refractive power profile. It is obtained by averaging the half meridians of all the measured refractive power data (in other words, the average is calculated by the radial polar coordinates, and the azimuth/meridian angle coordinates are not considered). The profile can be generated for a case or based on group average data. Assuming that, in the better case, the azimuthal frequency is unlikely to have significant significance beyond the fourth order, then there should be at least 8 meridians. Preferably, there are at least 32 meridians.

The refractive power data profile for the radial coordinate (distance from the center) is shown in FIG. All data from the semi-meridian is shown on the left. It can be used in non-rotationally symmetrical designs. The average, maximum and minimum values of the refractive power profile are shown on the right. The average value can be calculated by any conventional arithmetic average method including, but not limited to, an arithmetic mean, a median, or a geometric mean. It can be used for case-customization or group-based rotationally symmetric design.

Figure 3 shows the average right-eye refractive power profile (in other words, the adjusted stimulus is 0.17 D) for the case and the average group, adjusted for stimulation at a distance of 6 meters. It is approximately distal vision.

Figure 4 shows the adjusted left-eye refractive power profile (in other words, the modulation stimulus is 3.00 D) for the case and the average group at a distance of 0.33 meters. It represents near vision.

The group average refractive power profile for the distal and proximal stimulation levels is shown in Figure 5. These data are then used to determine the refractive power profile required for myopia control lenses.

Eye lens design method derived from power profile: Different data sources can be used to derive contact lens design for controlling myopia. Examples include: custom design based on case data, or group design based on specific subgroups in the data (for example, young Asian children aged 10-16), or based on all available data (eg all Myopia is designed for the general ethnic group.

Furthermore, both a rotationally symmetric design or a non-rotationally symmetric design can be produced by the method of the invention. Averaging the data of all considered semi-meridians (see Figure 5) can be used to generate a rotationally symmetric design, or if the data is retained in the form of a semi-meridian (left side of Figure 2), it can be used to create a non-rotationally symmetric design. Modifications for non-rotationally symmetrical designs, including but not limited to torics, spherical cylinders, spherical cylinders modified by higher order aberrations. The toric surface includes corrections to rules and irregular astigmatism.

The design produced by the present invention can be further fine-tuned according to the size of the pupil of the subject (or the group of subjects). In the natural state, the pupil size of the proximal adjustment level is usually smaller than the pupil size of the remote/distal adjustment level. Therefore, for the optical design of the orbital vision (coaxial), when measuring the near-end wavefront, based on the near-end wavefront, the power change used to control eye growth can be limited to optics corresponding to the presentation of smaller pupils. Zone diameter. Outside of the inner central region, the optical design can be restored to a distal visual state.

The following is an illustration of the design methodology for the use of average data obtained from all considered semi-meridians. In this way, a rotationally symmetric design is obtained (such designs do not need to be stabilized to reduce lens rotation).

method one:

In the first method, the average meridian and the near-end wavefront refraction are used as the starting point for the design. This design requires an increase in the refractive power of the lens (increasing the positive power) with an accompanying increase in the chord diameter from the center of the lens. This power increase is designed to offset the natural negative power offset, which is clearly visible in the group average data of the near-end wavefront power (Figure 6). The black arrow represents the desired positive power change. Therefore, the near-end wavefront is corrected to a zero-degree change.

Method Two:

In the second method, the average meridian and near-end wavefront refraction power is again used as the starting point of the design. However, in this method, the focal power changes are the average meridian and the far-end wavefront refractive power. This design requires an increase in the refractive power of the lens (increasing the positive power) with an accompanying increase in the chord diameter from the center of the lens. The increase in power is used to change the natural negative power offset, which is noticeable in the group average contour of the near-end wavefront power, greater than in the far-end wavefront power profile ( Figure 7). The black arrow represents the desired positive power change. If the patient requires a distal correction of -3.00 D, the lens power profile is: -3.000 D at the center of the lens, and the desired power is 0.25 D (net power -2.75) at a beam height of 0.6 mm. When the beam height is 1 mm, the required increase in power is 0.5 D (net power - 2.50 D). Figure 7 shows the power profile derived from the wavefront, and Figure 8 shows the power profile of a lens design that corrects the lens center error and extends to the surrounding contour in accordance with the above logic. This example shows that the design can be extended to a beam height of 1.6 mm (3.2 mm diameter), but it is understood that the design can be expanded if the wavefront measurement is expanded to a larger diameter. By appropriate mathematical calculations, the design can be extrapolated for beam heights up to 4 mm.

Figure 8 shows the final lens power profile based on the method described above.

Method three:

In another embodiment of the invention, the average meridian, near-end wavefront refractive power is again used as the starting point for the design. However, in this case, the target power change will double the difference between the average meridian and the far-end wavefront refraction. The preferred method is to double the difference, but the difference can be up to four times the far-end wavefront refraction. This design increases the refractive power of the lens (increasing the positive power) with an accompanying increase in the chord diameter from the center of the lens. The increase in power is used to change the natural negative power offset, which is clearly detectable in the group average contour of the near-end wavefront power and greater than in the far-end wavefront power profile. (Figure 9). The black arrow represents the desired positive power change. It can be understood that a multiplier of less than 1 unit is helpful, for example, a difference of 0.5. This may be closer to the patient's natural vision, but is still encompassed within the principles of the present invention.

In methods one through three, the design power profile is calculated according to the following formula: The optical power profile is described by an equation:

RPD(x) is the average far-end refractive power derived from the average wavefront, which is measured at the far end of the beam height x, and RPN(x) is the average near-end refractive power derived from the wavefront, which is tied to the beam. Height x is measured at the near end and k(x) is any suitable mathematical function. For example, a constant multiplier, preferably between 1 and 2, but the available range is extended by 0.25 to 4, or varies with x, with the inverse Stall-Croford effect (inverse Stiles Crawford) Effect). In the selected case, the RPD function can be replaced by a horizontal line with a slope of zero. RPD(0) is the refractive power of the far-end vertex derived from the average wavefront, and RPN(0) is the refractive power of the near-end vertex derived from the average wavefront measured at the beam height x.

In methods four through six, all considered half-meridian data is used instead of the average data for the semi-meridian. The result of this method is a non-rotationally symmetrical design. These designs need to be stabilized to reduce lens rotation.

Method four

In this embodiment of the invention, the near-end wavefront refractive power of the semi-meridian is the design starting point. This design requires an increase in the refractive power of the lens (increasing the positive power) with an accompanying increase in the chord diameter from the center of the lens. The increase in power is used to offset the natural negative power offset, which is clearly detectable in the group data of the near-end wavefront power.

For any meridian and chord position, when the power is negative, its power will be zeroed. This method is similar to Method 1, but can be applied to all positions of all meridians (unlike Method 1 using only average meridian data).

Method 5 and Method 6:

These methods are similar to method two and method three, respectively. In method five, each position of the power profile, when it is a negative power of the near-front wavefront, is moved to cooperate with the corresponding point of the far-end wavefront. In most instances, the far-end wavefront at either location has a positive power change, but in some instances, the power change is negative.

In method 6, each position of the power profile is doubled in such a way that the near-end wavefront is in negative power so as to match the desired power of the corresponding point of the far-end wavefront. If the far-end wavefront power change profile at either location is exactly negative, the design method can be modified so that the preset power of this position is equal to zero.

Method seven:

The wavefront diameter of the proximal stimulus is approximately 3.5 mm (beam height 1.75 mm), while the distal wavefront diameter is approximately 4 mm (beam height 2 mm). The power profile within 3.5 mm (in this example) of the central region can be designed in accordance with methods one through six described above. From the edge of the central region of 3.5 mm to the edge of the optic zone (for example: 7 mm), the design of the lens power change can be changed according to the power derived from the far-end wavefront described below (see 1.75 to 2 mm far). The black arrow in the front wave front). If the distal wavefront does not extend to the 7 mm edge of the optic zone, the power development can be extrapolated to obtain a power change or a power asymptote in the distal power profile.

This design approach attempts to limit the visual loss associated with near-end wavefront correction to control eye growth. This is by providing a correction that is specifically directed to the far-end wavefront of the optic zone of the lens (the area surrounding the optic zone) that is "activated" when the pupil optic zone is enlarged.

Another alternative, which does not optimize distal vision, is to enhance eyeball growth control by extrapolating the focal contour of the proximal wavefront edge to the 7 mm optic zone marginal zone.

Figure 10 presents an information flow diagram for implementing the method.

Figure 11 shows the application of this method to create a specific astigmatism or toric design. Figure 11A shows that the power profile is derived by subtracting the average power derived from the near end wavefront by the subtracting distal end. Figure 11B shows the meridian of a conventional toric lens having a power of -6.00 DS - 2.00 DC x 135.

Figure 12 shows a detailed power profile of a particular spherical lens design produced by this method, with vertex powers of -1.00 DS, -3.00 DS, and -6.00 DS. The profile shows the power of the shaft and the power to the periphery of the optical zone of the lens.

Figure 13 shows a detailed power profile of a special spherical lens design produced by this method, with a vertex of -9.00 DS, and a toric surface of -1.00 DS-1.00 DC x 45 and -3.00 DS-1.00 DC x 0 design. The profile is the power to display the power of the shaft to the periphery of the optical zone of the lens.

Figure 14 shows a detailed power profile of a particular astigmatic lens and toric lens design produced by the method having a vertex power of -6.00 DS-2.00 DC x 135 and -9.00 DS-1.00 DC x 90. The profile shows the power of the shaft to the peripheral power of the optical zone of the lens.

The method of the present invention can be embodied by a computer reading code on a computer reading medium. Computer-readable media refers to any storage device that can store data that can be read by a computer system. Examples of computer reading media include read only memory, random access memory, optical disk read only memory, digital video disc, magnetic tape, and optical data storage device. The computer reading medium can be distributed to a network-coupled computer system, allowing the computer to read the code for decentralized storage and execution.

The present invention is susceptible to use of computer programs and engineering techniques, including computer software, firmware, hardware, or any combination or subset. In accordance with the present invention, any program generated by a computer reading code can be embodied or supplied to one or more computer reading media to produce a computer program product, i.e., an article of manufacture. For example, the computer reading medium can be a fixed (hard) disk, a magnetic disk, a compact disk, a magnetic tape, a semiconductor memory such as a read only memory (ROM), or any like an internet, a communication network, or Connected transmission/reception medium. The article of manufacture containing the computer code can be used and/or generated by performing encoding directly from a single medium by copying the code from one medium to another, or transmitting the code from the network.

The apparatus according to the present invention may also be one or more processing systems including, but not limited to, a central processing unit (CPU), a memory, a storage device, a communication link and device, a server, an input/output device, or one to several processes. The secondary component of the system, including the software, firmware, hardware, and any combination or subset thereof, may be embodied in the invention contained in the claims.

The user input can be received by means of a keyboard, mouse, pen, sound, touch screen, or any other means by which humans can input data into the computer, including through other applications.

Those skilled in the art of computer science can combine the software created by the above-mentioned content with the computer hardware with appropriate or special purpose to create a computer system or computer subsystem that can specifically implement the present invention.

For example, using a computer to read computer instructions on the medium produces the above design. A design created in accordance with one of the above methods for producing lenses. Preferably, the lens is a contact lens. Exemplary materials for making soft contact lenses include, but are not limited to, silicone elastomers, ruthenium-containing macromolecules including, but not limited to, those disclosed in U.S. Patent Nos. 5,371,147, 5,314,960 and 5,057,578 (the aforementioned All patents are incorporated by reference in this application, as well as hydrogels and gels, and similar compositions and combinations thereof. More preferably, the surface layer is preferably a decane or a decane function, including but not limited to: polydimethyl siloxane macromolecules, methacryl oxiranes, mixtures thereof, ruthenium gels Or hydrogel. Exemplary materials include, but are not limited to, acquafilcon, etafilcon, genfilcon, lenefilcon, senefilcon, balafilcon, lotafilcon, or galyfilcon.

The lens material can be hardened by various convenient methods. For example, the material may be deposited in a mold, cured in the form of heat, radiation, chemicals, electromagnetic radiation, and the like, and similar and combinations thereof. Preferably, the molding is performed using the entire spectrum of ultraviolet or visible light. More specifically, the precise conditions suitable for curing the lens material are related to the choice of materials and the type of lens to be formed. Suitable processes are disclosed in U.S. Patent Nos. 4,495,313, 4,680,336, 4,889,664, 5,039,459, and 5,540,410, each of which is incorporated herein by reference.

The contact lenses of the present invention can be formed by a variety of convenient methods. One convenient method is to use a lathe to make a mold insert. The mold insert is then used to mold. Subsequently, a suitable lens material is placed between the dies, followed by compression and curing of the resin to form the lenses of the present invention. Those skilled in the art will recognize that any other known method can be used to produce the lenses of the present invention.

Figure 1 shows that the wavefront error is on the left side and the calculated refractive power is on the right side, both for the same eye.

Figure 2 shows a profile of the refractive power data plotted against the distance from the center. The left side shows all available meridians, and the right side shows the average, maximum and minimum values.

Figure 3 is a graph of the mean refractive power profile, which is the average of individuals or groups under adjusted stimulation conditions at a distance of 3 meters.

Figure 4 is a graph of the mean refractive power profile, which is the average of the individual or group of adjusted stimulation conditions at a distance of .33 meters.

Figure 5 shows the mean refractive power profile in the distal and proximal stimulation levels.

Figure 6 shows that the power increase is designed to offset the natural negative power offset displayed in the group average profile of the near-end wavefront power.

Figure 7 shows that the increase in power is designed to change the natural negative power offset, which is clearly visible in the group average of the average contour of the near-end wavefront power, greater than at the far end. In the wavefront power profile.

Figure 8 shows the final lens power profile of the method in accordance with the present invention.

Figure 9 shows that the increase in power is used to change the natural negative power offset, which is clearly visible in the group average data of the average contour of the near-end wavefront power, greater than the far-end wave. In the front power profile.

Figure 10 shows an information flow diagram implemented in one aspect of the method of the present invention.

Figures 11A-11B show lens power profiles designed in accordance with one aspect of the method of the present invention.

Figures 12A-12C show lens power profiles designed in accordance with one aspect of the method of the present invention.

Figures 13A-13C show lens power profiles designed in accordance with one aspect of the method of the present invention.

Figures 14A-14B show lens power profiles designed in accordance with one aspect of the method of the present invention.

Claims (29)

An ophthalmic lens comprising a design comprising a correction factor for proximal or distal vision based on wavefront data and pupil size, wherein the lens is used to slow or stop the development of myopia, wherein the wavefront data is a plurality of wavefronts The average of the files. The lens of claim 1, comprising: a convex surface having a central optical zone surrounded by a peripheral zone, the peripheral zone being surrounded by an edge zone, and a concave surface supported by the wearer On the eye; wherein the lens power at any position of the optical zone is described by the sum of the power derived from the far-end average wavefront of the axial apex plus a correction, wherein the correction is by a single, partial complex or The difference in power between the far-end and near-end average wavefronts at the respective positions (x), and the difference in power derived from the near-end and far-end wavefronts at the apex, the optical lens power is used for control Or slow down the development of myopia. A method of designing a contact lens, comprising: a) obtaining wavefront data, wherein the wavefront data is an average of a plurality of wavefront files; b) converting the wavefront data to a radial power map; c) generating a The lens power profile, which includes complex correction factors for near-end and far-end vision based on wavefront data and pupil size. The method of claim 3, wherein the wavefront data of the overall group is obtained. The method of claim 3, wherein the wavefront data of the subgroup is obtained. As described in claim 3, the wavefront data of one of the bodies is obtained. The method of claim 3, wherein the lens design has a power profile that calculates an average of all meridians for a rotationally symmetric form. The method of claim 3, wherein the focal length profile of the lens design is calculated as an inverted proximal power profile. The method of claim 3, wherein the lens design has a power profile calculated to offset negative aberrations of the near-end power profile. The method of claim 3, wherein the focal length profile of the lens design is calculated by adding a distance to the proximal power profile. The method of claim 3, wherein the lens power profile of the design is calculated by adding a near-end power profile to a multiple of the distance. The method of claim 37, wherein the lens power profile of the design is calculated by adding a portion of the distance to the proximal power profile. A device comprising a computer usable medium, and wherein the computer can use a medium to have computer readable instructions stored thereon for a processor to perform a method, wherein the method comprises: converting a wavefront data indicative of an eye feature to a Radial power diagram, and generation A lens power profile that includes a complex correction factor based on the wavefront data and the proximal or distal vision of the pupil size. An object according to claim 13 is for producing a lens design of a lens, the design comprising a convex surface having a central optical zone surrounded by a surrounding area, the surrounding area Surrounded by an edge zone and a concave surface supported on the wearer's eye. The article of claim 14, wherein the lens power at any position of the optical zone of the design is described by a sum of the power derived from the far-end average wavefront of the axial apex plus a correction amount, Wherein the correction amount is a focal difference derived from a single, partial complex or complex average wavefront at the distal and proximal ends of each position (x), and a focal length derived at the proximal and distal ends of the apex The degree difference is derived. The lens of claim 1, wherein the lens power is determined by the following: An ophthalmic lens for slowing the development of myopia comprises: a central optical zone, a surrounding zone and an edge zone; wherein the peripheral zone surrounds the central optical zone, the edge zone surrounds the surrounding zone; and the central optical zone is located The lens power includes an increasing one-degree power profile, wherein the far-end visual power to be corrected is gradually increased by at least 0.5 diopter greater than the power of the distal vision to be corrected, and the central optical zone further includes one in the optical power profile. maximum a value; wherein the optical power at the peripheral region has a power to correct a distal vision, wherein the central optical region has an outer diameter equal to or less than 8.0 mm. The lens of claim 17, wherein the central optical zone has an outer diameter equal to or less than 3.5 mm. The lens of claim 17, wherein the central optical zone has an outer diameter equal to or less than 5.3 mm. An ophthalmic lens for slowing the development of myopia comprises: a central optical zone, a surrounding zone and an edge zone; wherein the peripheral zone surrounds the central optical zone, the edge zone surrounds the surrounding zone; and the central optical zone is located The lens power includes an increasing one-degree power profile, wherein the far-end visual power to be corrected is gradually increased by at least 0.5 diopter greater than the power of the distal vision to be corrected, and the central optical zone further includes one in the optical power profile. a maximum value; wherein the optical power in the peripheral region has a power profile that is extrapolated from the optical power of the central optical zone, wherein the central optical zone has an outer diameter equal to or less than 8.0 mm. The lens of claim 20, wherein the central optical zone has an outer diameter equal to or less than 3.5 mm. The lens of claim 20, wherein the central optical zone has an outer diameter equal to or less than 5.3 mm. The lens of claim 20, wherein the extrapolation is a linear extrapolation. The lens of claim 23, wherein the linear extrapolation maintains the power gradient at the boundary of the central optical zone. The lens of claim 20, wherein the extrapolation refers to a higher order polynomial. The lens of claim 25, wherein the polynomial is at least a second order function. The lens of claim 25, wherein the polynomial is a continuous function comprising a continuous second derivative. A method for slowing the progression of myopia comprising: providing a patient lens having a central optical zone, a peripheral zone, and an edge zone; wherein the peripheral zone surrounds the central optical zone, the edge zone surrounding the peripheral zone; The lens power in the central optical zone comprises an increasing power profile which is increased by at least a greater than the power of the distal vision to be corrected by a refractive power of 0.5 diopter to be corrected, and the central optical zone is at optical power. The contour further includes a maximum value, and wherein the optical power located in the peripheral region has a power for correcting the distal vision, wherein the central optical region has an outer diameter equal to or smaller than 8.0 mm. A method for slowing the progression of myopia comprising: providing a patient-one lens having a central optical zone, a peripheral zone, and an edge zone; wherein the peripheral zone surrounds the central optical zone, the edge zone surrounding the surrounding zone The lens power in the central optical zone comprises an increasing power profile which is increased by at least a greater than the power of the distal vision to be corrected by a refractive power of 0.5 diopter to be corrected, the central optical zone being optically focused The degree profile further includes a maximum value; wherein the optical power in the peripheral region has a power profile from the central optical zone The optical power is extrapolated, wherein the central optical zone has an outer diameter equal to or less than 8.0 mm.