TWI498538B - Blood component detection device - Google Patents

Description

Blood component detecting element

The present invention relates to a blood component detecting element and a blood sampling device having the same, and more particularly to a blood component detecting element which is easy to handle and can be carried around.

According to statistics, the number of patients suffering from chronic diseases has increased in recent years. In the case of diabetes, patients with diabetes need to check their health regularly and regularly. For example, a blood sample should be taken every eight hours. The blood sample is examined for the concentration of a particular chemical composition in the blood of the patient. The diabetic patient as described above needs to test the blood glucose concentration of the diabetic patient. Therefore, for diabetic patients, blood glucose concentration testing should be performed every eight hours.

Among them, because the detection of blood glucose concentration is extremely important for diabetic patients, and needs to be performed every day, every eight hours, so the steps of blood glucose concentration detection or implementation is as simple as possible, so that every diabetic patient can easily An easy way to detect and track your health. More importantly, the conventional method of obtaining blood samples is usually to draw blood from the patient, and this will increase the pain of the patient, thereby causing the patient to reject the blood glucose concentration detection.

Furthermore, in order to maintain the accuracy of blood glucose concentration detection, a large amount of blood is drawn during the blood drawing process. Therefore, a large lancet is used in the blood drawing process to draw blood to quickly draw blood and obtain a large amount of blood sample. However, this will increase the pain of the patient and further reduce the patient's willingness to detect blood glucose. Especially for older patients, older patients are more willing to reject blood glucose levels for pain perception. As a result, the blood glucose concentration of diabetic patients cannot be effectively detected and monitored, and the health status of diabetic patients cannot be effectively grasped.

Therefore, it is a great boon for diabetic patients to develop a blood component detecting element that is easy to handle, can be carried around, and can improve the pain caused by the acquisition of a conventional blood sample.

SUMMARY OF THE INVENTION The main object of the present invention is to provide a blood component detecting element which can be carried around, is easy to handle, and can improve the pain caused by the blood sample.

In order to achieve the above object, a blood component detecting component of the present invention comprises: a capsule body having a first surface; an array of needles, the array needle comprising a plurality of needles, each of the needles having An opening and an inner hollow space, wherein each of the needles protrudes from the first surface; a detecting cavity, the detecting cavity system is located in the capsule body and communicates with the inner hollow space; The test wafer is disposed in the capsule body; and a plurality of sensing elements are disposed on the detection wafer.

The blood component detecting element is not limited in any shape. However, in the blood component detecting element of the present invention, the blood component detecting element is preferably in the form of a tablet. Furthermore, the blood component detecting element is preferably a disposable blood component detecting element.

In addition, the material of the needle described above is not limited at all. However, in the blood component detecting member of the present invention, the needle is preferably composed of a biocompatible material. Further, the material of the capsule body described above is not limited at all. However, in the blood component detecting member of the present invention, the capsule body is preferably composed of a biodegradable material.

Further, it is preferable that the needles are coated with an anesthetic agent, whereby when the needle is punctured through the skin of a subject, the subject does not feel pain due to the application of the anesthetic on the needle. It should be noted that the above-mentioned needle is preferably made by an imprinting process, and it is also worth noting that the mold used in the above-mentioned imprinting process is preferably a micro-die casting method. Process (LIGA process) is produced.

The present invention further provides a blood component detecting device comprising: a long strip having an upper surface; a plurality of the aforementioned blood component detecting elements, wherein the blood component detecting elements are disposed on the upper surface . Wherein, the blood component detecting elements are disposed on the first surface in an adhesive manner. It is to be noted that in the blood component detecting device described above, the adjacent two blood component detecting elements are preferably disposed at equal distances.

The present invention further provides a blood component sampling device, comprising: a housing having an opening; the blood component detecting device disposed in the housing; an elastic member disposed in the housing; A roller element is used to transport the blood component detecting device.

Wherein, the form of the above elastic member is not limited, and any elastic member can be applied to the blood component sampling device of the present invention. However, in the blood component sampling device of the present invention, the elastic member is preferably a spring. In addition, the blood component sampling device preferably further includes a top cover, and the top cover preferably covers one end of the opening of the housing.

The invention further provides a blood component sampling device, comprising: a casing; a finger cover disposed on the casing; a turntable disposed within the casing and having a central hole, the carousel Rotating the central hole as a shaft; a depth control resisting member having a plurality of sub-portions each having a different height; a plurality of blood component detecting groups each having a needle shape And a supporting unit; and a driving unit comprising a fixing portion and a moving portion, wherein the fixing portion is provided with a pushing portion; wherein the needle portion is disposed above the pushing portion.

The invention further provides a blood component sampling device, comprising: a casing; a finger cover disposed on the casing; a turntable disposed inside the casing and having a central hole, the carousel a plurality of blood component detecting groups each having a needle portion and a supporting portion; and a driving unit comprising a fixing portion and a moving portion; wherein The fixing portion is wound with a coil, and the moving portion is provided with a permanent magnet.

In the blood component sampling device of the present invention, the turntable is preferably rotated clockwise or counterclockwise.

The embodiments of the present invention are described by way of specific examples, and those skilled in the art can readily appreciate the other advantages and advantages of the present invention. In addition, the present invention may be embodied or applied in various other specific embodiments, and the details of the present invention may be variously modified and changed without departing from the spirit and scope of the invention. .

Example 1

Referring to FIG. 1A and FIG. 1B, FIG. 1A is a schematic diagram of a blood component detecting component according to Embodiment 1 of the present invention, and FIG. 1B is a blood component detecting method according to Embodiment 1 of the present invention. Side view of the component. As shown in FIG. 1A and FIG. 1B, the blood component detecting component 100 of the first embodiment of the present invention comprises: a capsule body 101, an array of needles 102, a detecting cavity 103, and a detecting wafer 104.

The array needle 102 described above includes a plurality of needles 1021. In addition to the above, the capsule body 101 described above surrounds the detection chamber 103 and the detection wafer 104. Furthermore, each needle 1021 protrudes from a first surface 1011 of the capsule body 101. The detection wafer 104 is located at the bottom of the detection cavity 103. Finally, as shown in Fig. 1A, the blood component detecting element 100 of the first embodiment of the present invention is in the form of a tablet.

As shown in Fig. 1B, the needle tip portion of each needle 1021 has an opening 1022 for use as an introduction port for a blood sample such as tissue blood. Furthermore, each needle 1021 also has an internal hollow space 1023 for receiving a blood sample introduced from the opening 1022, and the internal hollow space 1023 is located within the body of the needle. Furthermore, the inner hollow space 1023 in the body of each needle 1021 is in communication with the detection cavity 103 described above, so that the blood sample is introduced into the detection cavity 103 through the inner hollow space 1023, and the detection wafer 104 is This blood sample can be detected. Further, as shown in FIG. 1B, one surface of the detecting wafer 104 has one or more inductors 105 disposed therein, and the above-described inductor 105 faces the detecting cavity 103. It should be noted that, as described above, the number of the inductors 105 may be one or more, and in the blood component detecting component 100 of the first embodiment of the present invention, two inductors 105 are used to form an inductor 105. Array.

In the blood component detecting element 100 of the first embodiment of the present invention, the blood component detecting element 100 is of a disposable type. Among them, the needle 1021 on the blood component detecting element 100 is composed of a biocompatible material, and the other portion on the blood component detecting element 100 is composed of a biodegradable material. In addition to the above, the above-mentioned needle 1021 is produced by an imprinting process. Among them, the mold used in the imprint process is made by the LIGA process to maintain the high precision in size and direction of each of the needles 1021 in the array needle 102. In addition, in order to increase the efficiency of collecting blood samples, a special tapered design and grooves are formed on the tip of each needle 1021.

When the blood component detecting element 100 of the embodiment 1 of the present invention is used for determining whether a blood sample has a component to be detected and/or a concentration of the component to be detected in the blood sample (for example, determining a specific one in the blood sample) The chemical composition, or concentration of blood glucose, the array needle 102 is first driven. The above method of driving the array needle 102 is not limited, and it may be mechanical, electromagnetic, or manual. Further, the needle tip portion of the needle 1021 is pierced through the skin of a subject. It should be noted that each needle 1021 is coated with an anesthetic, so that when the needle tip portion of the needle 1021 is pierced through the skin of the subject, the subject does not have pain.

Wherein, the peripheral portion of the array needle 102 is pressed into the skin of the subject earlier than the rest of the array needle 102, thereby causing the needle 1021 at the peripheral portion of the array needle 102 to penetrate into the rest of the array needle 102. A portion of the needle 1021 is deeper to collect a blood sample. Subsequently, when the needle 1021 on the blood component detecting element 100 is placed on the skin of the subject after being taken, it is pulled away from the skin of the subject. At the same time, a negative pressure is formed in the detecting chamber 103, and the negative pressure causes the blood component detecting element 100 to draw a blood sample of the subject, and the blood sample passes through the opening 1022 of the needle 1021 and flows into the needle. The body. Finally, the blood sample is introduced into the detection chamber 103.

When the blood sample is introduced into the detection chamber 103, the blood sample flows to the sensor 105 and the detection wafer 104, so that the blood component detecting element 100 can perform detection. Subsequently, the test wafer 104, that is, the result of the detection, is output to a remote server for subsequent signal processing and analysis. The result of the detection is, for example, the blood glucose concentration in the blood sample described above or a specific chemical composition in the blood sample. In addition to this, the remote server can be, for example, a microprocessor of a blood glucose meter.

Example 2

Referring to Fig. 2, Fig. 2 is a schematic diagram of a blood component detecting device according to a second embodiment of the present invention. The embodiment of the blood component detecting device 200 according to the second embodiment of the present invention is similar to the embodiment of the blood component detecting device 100 of the first embodiment of the present invention, and the difference is that the blood component detecting device 200 of the second embodiment of the present invention is further A long strip 21 is included, and the strip has an upper surface 211.

Further, as shown in Fig. 2, the upper surface 211 is provided with a plurality of blood component detecting elements 100 as described in Embodiment 1 of the present invention. In addition to this, the blood component detecting element 100 is disposed on the first surface 211 with adhesive adhesion. Among them, the adjacent two blood component detecting elements 100 are equidistantly disposed. Other related descriptions of the same embodiment of the blood component detecting element 100 of the first embodiment of the present invention will not be described again.

Example 3

Referring to Fig. 3, Fig. 3 is a schematic diagram of a blood component sampling device according to a third embodiment of the present invention. As shown in FIG. 3, the blood component sampling device according to Embodiment 3 of the present invention comprises: a casing 31, a blood component detecting device 200 according to Embodiment 2 of the present invention, an elastic member 32, and at least one roller member 33.

The housing 31 has an opening 311, and the blood component detecting device 200 is disposed in the housing 31. Furthermore, the elastic member 32 is also disposed in the housing 31. It should be noted that, as shown in FIG. 3, the roller member 33 is configured to transport the blood component detecting device 200, and a blood component detecting device 100 on the blood component detecting device 200 protrudes from the opening 311. Outside the housing 31.

As shown in FIG. 3, the blood component sampling device of the third embodiment of the present invention further includes a top cover 34, and the top cover 34 is preferably sleeved on one end of the opening 311 of the housing 31, and is formed with The accommodation space 35. When the blood component sampling device of the third embodiment of the present invention is used, a finger 36 of a subject first extends into or through the accommodating space 35.

Subsequently, the elastic member 32 pushes the blood component detecting element 100 located at the opening 311, so that the needle on the blood component detecting element 100 can be inserted into the skin of the subject's finger to perform a blood drawing operation. After the blood is again taken, the elastic member 32 is pushed back to the original position and the roller member 33 is rotated. By the rotation of the roller member 33, the long strip is driven, the used blood component detecting element 100 is transported from the opening 311, and the untreated blood component detecting element 100 is transported to the opening 311 for the next blood. Component detection.

Therefore, the blood component detecting element 100 after use is stored in the casing 31, and after the blood component detecting element 100 mounted in the blood component sampling device of the third embodiment of the present invention is used, the blood component sampling device is discarded. . With the above-mentioned good storage mechanism, the problem of bio-waste caused by improper handling of the blood component detecting element 100 can be largely discarded.

Example 4

Referring to Figures 4A, 4B, and 4C, a blood component sampling device according to a fourth embodiment of the present invention. 4A is a side view of a blood component sampling device according to a fourth embodiment of the present invention, FIG. 4B is a first schematic view of a blood component sampling device according to a fourth embodiment of the present invention, and FIG. 4C is a blood component sampling device according to a fourth embodiment of the present invention. The second schematic. As shown in FIG. 4A, FIG. 4B, and FIG. 4C, the blood component sampling device 400 of the fourth embodiment of the present invention includes a housing 401, a finger cover 402, a turntable 403, a depth control resistor 404, and a plurality of The blood component detecting group 405 and a driving unit 406.

The turntable 403 has a central hole 4031. Therefore, the turntable 403 has a central hole 4031 corresponding to the shaft of the housing 401, so that the turntable 403 can be pivoted by the central hole 4031. Furthermore, the turntable 403 further has a plurality of openings 4032, and in the blood component sampling device of the fourth embodiment of the present invention, the number of the openings 4032 is 8. In addition, each opening 4032 is configured with a window hole 4033.

Furthermore, each blood component detecting group 405 corresponds to one opening 4032 of the turntable 403. In the blood component sampling device according to the fourth embodiment of the present invention, each of the blood component detecting groups 405 has a needle portion 4051 and a support portion 4052.

Referring again to FIG. 4A, the finger cover 402 is located at the top of the housing 401. In addition, the depth control block 404 described above is disposed within the housing 401 to control the depth of travel of the blood component detecting group 405 toward the finger cover 402. Furthermore, as shown in FIG. 4C, the depth control block 404 includes a plurality of sub-portions, each of which has a different height, so that the blood component detecting group 405 can be controlled to have different depths of travel. That is, if it is necessary to make the blood component detecting group 405 have a large traveling depth, it can be achieved by moving the above-described depth control stopper 404. There is no limitation on the manner of moving the above-mentioned depth control block 404, for example, it can be moved by electric driving or mechanically.

After the blood is collected, the turntable 403 is rotated to a position where one of the plurality of openings 4032 is located below the finger cover 402. Subsequently, the depth control block 404 is set at a preset position to control the depth of travel of the blood component detecting group 405.

Next, how the mechanism related to how the blood component detecting group 405 moves upward will be described in more detail how it is driven by the movement of the driving unit 406. Please refer to FIG. 4D, FIG. 4E, and FIG. 4F, respectively. 4D is a first schematic diagram of a driving unit of a blood component sampling device according to Embodiment 4 of the present invention, FIG. 4E is a second schematic diagram of a driving unit of the blood component sampling device according to Embodiment 4 of the present invention, and FIG. 4F is an embodiment of the present invention. A third schematic diagram of the drive unit of the blood component sampling device of 4.

As shown in FIG. 4D, the driving unit 406 includes a fixing portion 4061 and a moving portion 4062, and the fixing portion 4061 is provided with a pushing portion 4064. In addition, as shown in FIG. 4D, the pushing portion 4064 is located below the blood component detecting group 405, and the needle portion 4051 is located above the pushing portion 4064.

First, as shown in Fig. 4D, the moving portion 4062 is in an original position, as shown on the right side as shown in Fig. 4D. Next, the moving portion 4062 moves to the left side and gradually approaches the fixed portion 4061. As shown in Figure 4E. When the moving portion 4062 is gradually approached to the fixing portion 4061, the fixing portion 4061 is raised, and the pushing portion 4064 is also lifted upward, and the needle portion 4051 and the supporting portion 4052 of the blood component detecting group 405 are lifted together.

Referring to FIG. 4E again, it is worth noting that the needle portion 4051 and the support portion 4052 are not lifted without limitation. As shown in FIG. 4E, after the needle portion 4051 and the support portion 4052 are lifted to a certain height, the depth control stopper 404 can catch the support portion 4052 to prevent the needle portion 4051 and the support portion 4052 from being lifted without restriction.

As shown in FIG. 4F, the moving portion 4062 continues to move to the left side, and the fixing portion 4061 is completely removed. As such, the raised fixed portion 4061 will be returned to the position shown in FIG. 4D. As can be seen from the above description, when the fixing portion 4061 is raised to the position shown in FIG. 4E, the needle portion 4051 can penetrate the skin of a subject to perform blood sample collection. Subsequently, after the blood sample collection is completed, the turntable 403 is rotated to the next position such that the other opening 4032 is positioned below the finger cover 402. Furthermore, the rotation of the turntable 403 can be mechanical, electromagnetic, or manual. The rotation direction of the turntable 403 can be clockwise or counterclockwise.

When the needle portions 4051 on all of the blood component detecting groups 405 are used, the turntable 403 can be removed from the housing 401 and replaced with an unreturned turntable 403.

Example 5

The embodiment of the blood component sampling device of the fifth embodiment of the present invention is similar to the embodiment of the blood component sampling device of the fourth embodiment of the present invention. Therefore, the following description will be made only for the different embodiments, and the same embodiment will not be added. Narration.

Please refer to FIG. 5A, FIG. 5B, and FIG. 5C. 5A is a first schematic diagram of a driving unit of a blood component sampling device according to Embodiment 5 of the present invention, FIG. 5B is a second schematic diagram of a driving unit of a blood component sampling device according to Embodiment 5 of the present invention, and FIG. 5C is an embodiment of the present invention. A third schematic diagram of the drive unit of the blood component sampling device of 5.

The difference between the embodiment of the blood component sampling device according to the fifth embodiment of the present invention and the embodiment of the blood component sampling device of the fourth embodiment of the present invention is that the driving unit of the blood component sampling device according to the fourth embodiment of the present invention is a mechanical device. The driving unit of the blood component sampling device of the fifth embodiment of the present invention is electromagnetic.

Referring to FIG. 5A again, the moving portion 5062 is provided with a permanent magnet 501, and the supporting portion 5052 is wound with the coil 502. Next, a current (not shown) is applied to the coil 502, and the coil 502 induces a magnetic field (not shown) after the current is applied. Subsequently, under the magnetic interaction, the moving portion 5062 is lifted upward as shown in Fig. 5B. At the same time, when the support portion 505 is lifted up to the position shown in FIG. 5B by the moving portion 5062, the needle portion 5051 can penetrate the skin of a subject to perform blood sample collection.

When the collection of the blood sample is completed, the current flowing into the coil 502 is turned off, whereby the moving portion 5062 is returned to the original position as shown in Fig. 5A.

The above-mentioned embodiments are merely examples for convenience of description, and the scope of the claims is intended to be limited to the above embodiments.

100, 200‧‧‧ blood component detection components

101‧‧‧Capsule body

21‧‧‧Long strip

102‧‧‧Array needles

103‧‧‧Detecting cavity

104‧‧‧Detection wafer

105‧‧‧ sensor

1021‧‧‧ needle

1011‧‧‧ first surface

1022‧‧‧Opening

1023‧‧‧ hollow space

211‧‧‧ upper surface

31‧‧‧Shell

32‧‧‧Flexible components

33‧‧‧Rolling elements

311‧‧‧ openings

34‧‧‧ Cover

35‧‧‧ accommodating space

36‧‧‧ fingers

401‧‧‧shell

402‧‧‧ Finger cover

403‧‧‧ Turntable

404‧‧‧Deep control block

405‧‧‧ Blood Component Testing Group

406‧‧‧ drive unit

4031‧‧‧Central hole

4032‧‧‧ openings

4033‧‧‧ window hole

4051‧‧‧ needle department

4052‧‧‧Support Department

4061‧‧‧Fixed Department

4062‧‧‧Mobile Department

4064‧‧‧Promotion Department

5062‧‧‧Mobile Department

501‧‧‧ permanent magnet

5052‧‧‧Support Department

502‧‧‧ coil

5051‧‧‧ needle department

Fig. 1A is a schematic view showing a blood component detecting element according to a first embodiment of the present invention.

Fig. 1B is a side view showing a blood component detecting element of Embodiment 1 of the present invention.

Fig. 2 is a schematic view showing a blood component detecting device according to a second embodiment of the present invention.

Fig. 3 is a schematic view showing a blood component sampling device according to a third embodiment of the present invention.

Fig. 4A is a side view showing a blood component sampling device of a fourth embodiment of the present invention.

Fig. 4B is a first schematic view showing a blood component sampling device according to a fourth embodiment of the present invention.

Figure 4C is a second schematic view of the blood component sampling device of Embodiment 4 of the present invention.

Fig. 4D is a first schematic view showing the driving unit of the blood component sampling device of the fourth embodiment of the present invention.

Fig. 4E is a second schematic view showing the driving unit of the blood component sampling device of the fourth embodiment of the present invention.

Fig. 4F is a third schematic view showing the driving unit of the blood component sampling device of the fourth embodiment of the present invention.

Fig. 5A is a first schematic view showing a driving unit of a blood component sampling device according to a fifth embodiment of the present invention.

Fig. 5B is a second schematic view showing the driving unit of the blood component sampling device of the fifth embodiment of the present invention.

Fig. 5C is a third schematic view showing the driving unit of the blood component sampling device of the fifth embodiment of the present invention.

100‧‧‧ Blood component detection component

101‧‧‧Capsule body

102‧‧‧Array needles

103‧‧‧Detecting cavity

104‧‧‧Detection wafer

105‧‧‧ sensor

1021‧‧‧ needle

1011‧‧‧ first surface

1022‧‧‧Opening

1023‧‧‧ hollow space

Claims (15)

A blood component detecting component comprising: a capsule body having a first surface and a second surface opposite to the first surface, and the capsule system is composed of a biodegradable material An array of needles, the array of needles comprising a plurality of needles, each of the needles having an opening and an inner hollow space, each of the needles projecting from the first surface, wherein the needles are a needle tip and an end portion, wherein a surface of the tip portion and the first surface are at an angle smaller than an angle between the surface of the end portion and the first surface, and the needles are biocompatible a biocompatible material; a detection cavity, the detection cavity system is located in the capsule body, and is connected to the inner hollow space; a detection wafer, the detection wafer is disposed in the capsule body, and is disposed on the The second surface of the capsule body; and a plurality of sensing elements disposed on the detecting wafer. The blood component detecting element according to claim 1, wherein the blood component detecting element is in the form of a tablet. The blood component detecting element according to claim 1, wherein the blood component detecting element is a disposable blood component detecting element. The blood component detecting element according to claim 1, wherein the needles are coated with an anesthetic. The blood component detecting element according to claim 1, wherein the needles are produced by an imprinting process. The blood component detecting element according to claim 1, wherein the mold used in the imprinting process is produced by a LIGA process. A blood component sampling device comprising: a blood component detecting element comprising a long strip having an upper surface; and a plurality of blood components according to any one of claims 1 to 6 a detecting component, wherein the blood component detecting component is disposed on the upper surface; a casing having an opening; an elastic component disposed in the casing; and at least one roller component for conveying the a blood component detecting device; wherein the long strip and the blood component detecting elements are disposed in the housing. . The blood component sampling device according to claim 7, wherein the blood component detecting elements are disposed on the first surface in an adhesive manner. The blood component sampling device according to claim 7, wherein the two adjacent blood component detecting elements are equidistantly disposed. The blood component sampling device according to claim 7, wherein the elastic member is a spring. The blood component sampling device of claim 7, wherein the blood component sampling device further comprises a top cover covering one end of the opening of the housing. A blood component sampling device includes: a casing; a finger cover disposed on the casing; a turntable disposed within the casing and having a central hole, the carousel being centered on the shaft a rotation control unit having a plurality of sub-portions each having a different height; a plurality of blood component detecting groups each having a needle portion and a support portion And a driving unit comprising a fixing portion and a moving portion, and the fixing portion is provided with a pushing portion; wherein the needle portion is disposed above the pushing portion. The blood component sampling device according to claim 12, wherein the turntable rotates clockwise or counterclockwise. A blood component sampling device includes: a casing; a finger cover disposed on the casing; a turntable disposed within the casing and having a central hole, the carousel being centered on the shaft a plurality of blood component detecting groups each having a needle portion and a supporting portion; and a driving unit comprising a fixing portion and a moving portion; Wherein, the fixing portion is wound with a coil, and the moving portion is provided with a permanent magnet. The blood component sampling device according to claim 14, wherein the turntable rotates clockwise or counterclockwise.