TWI497064B - Apparatus and method for detecting vaporization - Google Patents

Description

Vaporization detecting device and method

This case relates to a system and method that can be used to measure the moisturizing efficacy of a sample to be tested. Specifically, the system and method of the present invention measure an electrical property of the sample to be tested to detect a vaporization amount of a target substance from the sample to be tested, and thereby reflect the moisturization of the sample to be tested. efficacy.

As far as the prior art is concerned, the water content of the sample or the vaporization amount of the vaporizable substance therein is currently measured by the weighing method. For example, in the patent application of No. 201028683 of the Republic of China, a method for detecting the moisture content of a high-humidity agricultural product is disclosed, which is to take an appropriate amount of the sample to be tested, and the sample to be tested is weighed and chopped, Put in a fixed volume container, and then pour the water of known density into the container to the preset volume (VC), and then subtract the volume of the water (VW) into the container and subtract the volume from the preset volume. Measure the volume (VT) of the sample, and then calculate the water content (WW) and the dry weight (WD) of the sample to be tested, or calculate one of them, and then calculate the sample to be tested and the water content or the sample to be tested and the dry matter. Knowing the moisture content (MC) of the sample to be tested, the weight or the ratio of one of them is used to solve the problem that the conventional oven method cannot quickly obtain the moisture content of the high-humidity agricultural product.

On the other hand, if the weight of the vaporizable material in the sample is measured by the weighing method Quantity, this measurement process not only requires a large number of samples, so that the vaporization amount is more obvious and easy to observe, this measurement process also takes a lot of time, and since it is difficult to automatically record the vaporization amount data in parallel, it is worth investing in The big manpower and material resources have to be completed.

The applicant has carefully designed and researched and has a spirit of perseverance and finally conceived the "vaporization detection device and method" of the case. The following is a brief description of the case.

The object of the present invention is to measure the electrical property of one of the samples to be tested to detect a vaporization amount of a target substance from the sample to be tested, and thereby reflect the moisturizing effect of the sample to be tested.

To achieve the above objective, the present invention provides a measurement system comprising: a first electrode; a first sample to be tested, comprising a first vaporizable substance, wherein the electrode is in contact with the first sample to be measured for measurement The first test sample has a first electrical property during a first measurement period, and the first vaporizable material has a first vaporization amount vaporized from the first sample to be tested during the period a second electrode; and a second sample to be tested, comprising a second vaporizable substance, wherein the electrode is in contact with the second sample to be tested to measure the second sample to be tested during a second measurement period One of the second electrical properties, and the second vaporizable material has a second vaporization amount vaporized from the second sample to be tested during the period.

To achieve the above object, the present invention provides a method for detecting vaporization properties of a sample, comprising the steps of: providing a sample to be tested comprising a vaporizable substance; and measuring one of the samples to be tested during a measurement period a property of detecting a vaporization amount of the vaporizable substance from the sample to be tested during the measurement period.

In order to achieve the above object, the present invention provides a method for continuously detecting a sample vaporization amount, which comprises the steps of: providing a sample to be tested, comprising a target substance; and measuring an electrical property of the sample to be tested during every interval. In order to detect a vaporization amount of the sample from the sample to be vaporized.

In order to achieve the above object, the present invention provides a measuring system comprising: an electrode; and a sample to be tested, comprising a target substance, wherein the electrode is in contact with the sample to be tested to measure the sample to be tested in an amount One of the electrical properties during the measurement period, and the target material has a vaporization amount vaporized from the sample to be tested during the period.

To achieve the above object, the present invention provides a method for detecting vaporization of a sample, comprising the steps of: providing a sample to be tested, comprising a target substance; and measuring an electrical property of the sample to be detected to detect the target The substance is vaporized from one of the samples to be tested.

In order to achieve the above object, the present invention provides a detection method comprising the steps of: providing a sample to be tested; measuring a change in one of the electrical properties of the sample to be tested during a measurement period; providing a reference change amount , the reference change amount Table 1 shows a concentration of the reference substance; and compares the amount of the change with the amount of the reference change to know how much the reference substance is contained in the sample to be tested.

For ease of explanation, the present invention can be further understood by the following examples.

The apparatus and method of the present invention will be fully understood from the following description of the examples and may be accomplished by those skilled in the art. However, the implementation of this case is not limited to the following examples.

Please refer to the first (A) diagram, which is a schematic diagram of the apparatus for detecting the vaporization amount of the vaporizable substance in the sample 10 to be tested. In the first (A) diagram, the sample to be tested 10 is a conductive sample having a vaporizable substance and placed on the measuring surface 111 of the electrode 11, and a space is partitioned by the space 12 to accommodate Sample 10 was measured. The sample 10 to be tested is in contact with the measuring surface 111 to form the end surface 101, and the electrode 11 is used as a measuring interface through the end surface 101 to measure an electrical property of the sample 10 to be tested.

Please refer to the first (B) diagram, which is a schematic diagram of the apparatus for detecting the vaporization amount of the vaporizable substance in the sample 10 to be tested. In detail, the one shown in the first (B) is a state which is presented after being placed for a period of time in the state shown in the first (A). In the first (B) diagram, since the sample to be tested 10 contains a vaporizable substance, the vaporizable substance will vaporize from the sample to be tested 10 as time increases. Therefore, compared to the first (A) and one (B) figures, the first (B) can be seen. The liquid level of the sample 10 to be tested in the figure is significantly lower than that shown in the first (A) diagram, which is caused by vaporization of the vaporizable substance from the sample 10 to be tested.

In the first (A) diagram, the electrode 11 has passed through the measurement interface of the end face 101, and the value of the electrical property of the sample 10 to be tested and its variation are measured. Then, in the time that the sample 10 to be tested is from the first (A) to the first (B), the electrode 11 continues to pass through the measurement interface of the end surface 101, and the electrical property of the sample 10 to be tested is measured, thereby detecting And reflecting the state in which the vaporizable substance is vaporized from the sample to be tested 10.

In detail, during the time from the first (A) to the first (B), since the vaporizable substance is vaporized from the sample to be tested 10, the concentration of the current-carrying electrolyte in the sample 10 to be tested will be caused. The rise causes the electrical properties of the sample 10 to be tested to change. This change in electrical properties will be measured by electrode 11 measurement. Therefore, with the above embodiment, the present invention does provide a method for detecting the volatile matter of a sample, and the value of the electrical property can also be converted into the actual vaporization amount of the vaporizable substance.

Wherein, the electrical property may be resistance, current, capacitive reactance, electrical impedance, or any combination thereof, etc., but the vaporization state of the vaporizable substance shall be the same. In addition, the electrode 11 can be continuously measured through the end surface 101 to measure the electrical properties of the sample 10 to be tested, and can be set to be measured after each interval. In addition, the function of the electrode 11 is to measure the electrical properties of the sample 10 to be tested, so that the electrode 11 can only pass through the end face as shown in the first (A) or (B) diagram. The 101 measurement is not only a planar electrode. Specifically, as long as the energy of the sample 10 is measured by the energy, the electrode becomes a unit of a measurement system, similar to that shown in the first (A) or (B) diagram, or Any one of the electrical mass measuring devices (commonly used as a current/voltage meter) can be used in the embodiment of the present invention. That is, a commercially available electrical quality measuring device can also be applied to the embodiments of the present invention.

Please refer to the second figure, which is a schematic diagram of the measurement of the electrical impedance of the sample to be tested to reflect the vaporization state of the vaporizable material in the sample to be tested. In the second figure, the first sample to be tested (water) and the second sample to be tested (water containing 10 w/w% glycerol) are continuously dosed for a certain period of time and under the same environmental conditions. After measuring the electrical impedance value and recording, the curves A and B are obtained. Subsequently, after taking the curves A and B as the trend lines, the trend lines a and b are obtained, respectively.

That is, as described in the above specification, since the vaporizable substance is continuously vaporized from the sample to be tested, the concentration of the current-carrying electrolyte in the sample to be tested will rise, thereby causing the electrical resistance of the sample to be tested to decrease. In the second figure, since the second sample to be tested further contains 10 w/w% of glycerol compared to the first sample to be tested, the water in the second sample to be tested will be vaporized due to the glycerol. It is slower than the water of the first sample to be tested. Therefore, in a unit time, the electrical resistance value of the second sample to be tested will decrease more slowly than that of the first sample to be tested. When this phenomenon is reflected to the trend lines a and b, it can be similarly found that the slope (resistance value/time) of the trend line b is smaller than the slope of the trend line a. In other words, in the unit time, the second test The vaporization amount of water in the sample will be smaller than that of the first sample to be tested, and the second sample to be tested can be regarded as having a better moisturizing effect than the first sample to be tested.

Summary As mentioned above, it is known that the electrical properties (such as electrical impedance) of the sample to be tested can reflect the vaporization and/or moisturizing effect of the sample to be tested.

Please refer to the third (A) and third (B) maps. When measuring the vaporization amount of water and water containing 5%, 10%, 15%, 20% and 30% (w/w) glycerol, respectively, under the same volume and environmental conditions using conventional weighing methods, The hourly actual vaporization amount (mg/hr) is summarized as shown in the third (A) chart. Under the same experimental materials and conditions as in the third (A) diagram, the above-mentioned embodiment of the present invention is used to measure the electrical impedance value to reflect the amount of change in electrical resistance per hour (ohm/hr, ie, The same as the meaning represented by the slope of the trend line b in the second figure is summarized as shown in the third (B) diagram. The measurement data of the third (A) and third (B) diagrams are shown in Table 1 below.

In the third (A) and Table 1, the hourly vaporization of water measured by the weighing method is about 3 mg, and the absolute value of the change is not large. In the case of 5% glycerol, the difference between the vaporization of water and the absence of glycerin is very small. Even if the system already contains 20% glycerol, the difference between the vaporization of water and the non-glycerin is only about 15%. That is to say, when the vaporization amount is measured by the weighing method, it is difficult to measure not only because the vaporization amount is small, but also if the content of the component (such as glycerin) which affects the vaporization amount changes, it is not easy to observe the vaporization amount. Moreover, the amount of vaporization obtained by the weighing method is small, so that some slight errors in the amount of vaporization during the measurement will cause a large gap between the actual glycerin content and the actual glycerin content.

In contrast, as shown in the third (B) and Table 1, when the vaporization amount of water measured by the electrical impedance method is changed, the electrical resistance value is more than 200 ohm/hr, which is easy to observe, and when 5% glycerin is contained. The change in electrical impedance value is more than 15% compared with those without glycerin, and with the gradual increase of glycerol content, the individual electrical impedance value changes are more than the difference between those without glycerin. It is obvious.

According to the third (B) and Table 2, when the vaporization amount is measured by the electrical impedance method, it is easy to observe not only because the value of the electrical impedance change is large, but also the content of the component (such as glycerin) which affects the vaporization amount. At the same time, the amount of change in electrical impedance will also change significantly. That is to say, it can be seen from this embodiment that the measurement of the vaporization amount by the electrical impedance method will have extremely high sensitivity. In addition, since the amount of electrical impedance change per unit time is large when the amount of vaporization is measured by the electrical impedance method, there is a slight error in measuring the amount of electrical impedance change, and when estimating the glycerin content, Nor will it cause too much disparity. Therefore, it can also be seen from this embodiment that the measurement of the vaporization amount by the electrical impedance method has extremely high accuracy.

Furthermore, by taking the data shown in the third (A) and third (B) graphs and obtaining the relationship, the electrical impedance change amount can be actually converted into the actual vaporization amount of water. In detail, the resistance change amount (ohm/hr) of each group shown in the third (B) diagram is set to x, and the actual vaporization amount of water in each group shown in the third (B) diagram (mg) /hr) Set to y, you can get: y = 0.0022x + 2.551 (Formula 1).

Through the formula 1, if the sample to be tested containing glycerol is known, it is the same as the experimental condition (such as temperature, humidity and sample vaporization area (such as the area of contact of the liquid sample with air), which affects the vaporization amount, etc. The amount of hourly electrical impedance change in the case of the three (B) diagram can be used to know the actual vaporization amount of water per hour in the sample to be tested. Of course, vice versa.

Please refer to the third (C) diagram, which is a quantified map of the data in the third (A) and third (B) diagrams. In detail, in the third (A) and three (B) graph data, the hourly vaporization amount or the electrical impedance value change amount of water is defined as 1, and then in the third (A) and third (B) graphs, respectively. The vaporization rate or the resistance change value of various glycerol per hour is calculated, and the vaporization rate relative to water is calculated separately, which is shown in the third (C) diagram. The value of 0% to 20% in the third (C) diagram represents the glycerin content contained in the figure.

According to the third (C) chart, the difference in the electrical impedance change recorded by the glycerin containing various contents is significantly greater than that measured by the weighing method. That is, the above embodiment of the present invention does provide a more sensitive apparatus and method for detecting the vaporization state and/or vaporization amount of a sample to be tested.

Please refer to Figures 4(A) and 4(B). When using the traditional weighing method, the same volume and environmental conditions, respectively, when measuring the vaporization amount of water and water containing 0.01%, 0.1% and 1% (w/w) hyaluronic acid, the hourly vaporization amount (mg/ Hr) is summarized as shown in the fourth (A) chart. Under the same experimental materials and conditions as in the fourth (A) diagram, the above-mentioned embodiment of the present invention is used to measure the electrical impedance value to reflect the amount of change in electrical resistance per hour (ohm/hr, ie, The same as the meaning represented by the slope of the trend line b in the second figure is summarized as shown in the fourth (B) diagram. Among them, the third (A), three (B), four (A) and four (B) diagrams are identical except for the respective measurement methods and the glycerol and hyaluronic acid as described above. The measurement data of the fourth (A) and fourth (B) diagrams are shown in Table 2 below.

In the fourth (A) and Table 2, the hourly vaporization amount of water measured by the weighing method is about 3.2 mg, and the absolute value of the change is not large. In the case of 0.01% hyaluronic acid, the difference between the vaporization of water and the absence of hyaluronic acid is very small. Even if the system already contains 1% hyaluronic acid, the difference between the vaporization of water and the absence of hyaluronic acid is only about 20%. That is to say, when the vaporization amount is measured by the weighing method, it is difficult to measure not only because the vaporization amount is small, but also if the content of the component (such as hyaluronic acid) which affects the vaporization amount changes, it is not easy to observe the vaporization amount. Moreover, the amount of vaporization obtained by the weighing method is small, so the slight error in the amount of vaporization during the measurement will cause a large gap between the actual hyaluronic acid content and the actual hyaluronic acid content.

In contrast, as shown in the fourth (B) and Table 2, when the vaporization amount of water measured by the electrical impedance method is changed, the electrical resistance value is more than 370 ohm/hr, which is easy to observe, and when 0.01% hyaluronic acid is contained. The change in electrical impedance value is about 20% lower than that of non-hyaluronic acid. With the increasing hyaluronic acid content, the individual electrical impedance changes are more than the difference between those without hyaluronic acid. It is obvious that even when 1% hyaluronic acid is contained, the amount of electrical impedance change is about one tenth of that without hyaluronic acid (ie, only water).

According to the fourth (B) and Table 2, when measuring the vaporization amount by the electrical impedance method, it is easy to observe not only because the value of the electrical impedance change is large, but also the content of the component (such as hyaluronic acid) which affects the vaporization amount. At the same time, the amount of change in the electrical impedance value also causes a significant change. That is to say, by using this embodiment, it is known that The electrical impedance method measures the amount of vaporization and will have extremely high sensitivity. In addition, since the amount of change in electrical resistance per unit time is large when the amount of vaporization is measured by the electrical impedance method, there is a slight error in the amount of change in the electrical resistance value, and it is not caused when the hyaluronic acid content is estimated. Too big a gap. Therefore, it can also be seen from this embodiment that the measurement of the vaporization amount by the electrical impedance method has extremely high accuracy.

Furthermore, by taking the data shown in the fourth (A) and fourth (B) graphs and obtaining the relationship, the amount of change in the electrical impedance value can be actually converted into the actual vaporization amount of water. In detail, the resistance variable value (ohm/hr) of each group shown in the fourth (B) diagram is set to x, and the actual vaporization amount of water in each group shown in the fourth (B) diagram ( When mg/hr is set to y, it can be obtained: y=0.0016x+2.5627 (Formula 2).

Through the formula 2, if the sample to be tested containing hyaluronic acid is known, it is the same as the experimental condition (such as temperature, humidity and sample vaporization area (such as the area of contact of the liquid sample with air), which affects the vaporization amount, etc. The amount of hourly electrical impedance change in the condition of the four (B) diagram can be used to know the actual vaporization amount of water per hour in the sample to be tested. Of course, vice versa.

Please refer to the fourth (C) diagram, which is a quantized graph of the data in the fourth (A) and fourth (B) diagrams. In detail, in the fourth (A) and fourth (B) graph data, the hourly vaporization amount or the electrical impedance value change amount of water is defined as 1, and then the fourth (A) and fourth (B) graphs are respectively After varying the amount of vaporization or electrical impedance per hour of various content of hyaluronic acid, the vaporization relative to water was calculated separately. The rate is shown in the fourth (C) diagram. The value of 0% to 1% in the fourth (C) diagram represents the hyaluronic acid content contained in the figure.

According to the fourth (C) diagram, the difference in the electrical impedance change recorded by the hyaluronic acid containing various contents is significantly greater than that measured by the weighing method. That is, the above embodiment of the present invention does provide a more sensitive apparatus and method for detecting the vaporization state and/or vaporization amount of a sample to be tested.

Please refer to the fifth figure, which is a summary graph of the vaporization rate of water containing glycerin and hyaluronic acid in the third (C) and fourth (C) graphs, respectively, using an electrical impedance method. As can be seen from the fifth figure, the moisturizing effects of glycerin and hyaluronic acid can correspond to each other. For example, the moisturizing effects of 0.01% and 0.1% hyaluronic acid are equivalent to the moisturizing effect of 7% and 11% glycerol, respectively. That is, through the above embodiments, various moisturizing components which reduce the vaporization amount of water can be compared with each other, and a new moisturizing component can be evaluated, which is the same as the known moisturizing component. Moisturizing effect to judge the effect of this new moisturizing ingredient.

Furthermore, it can be seen from the above embodiments that if a new sample to be tested does not know the concentration or effect of the moisturizing component, the new sample to be tested can be passed through the above electrical impedance method to measure the electrical impedance change value, and then One or more reference electrical impedance change values of a sample containing a known component and concentration of a moisturizing component (eg, various levels of glycerin) (where the reference electrical impedance change value is obtained by using the above embodiments), Experimental conditions that affect the amount of vaporization (eg temperature, Humidity and sample vaporization area (such as the area where the liquid sample is in contact with air), etc., which are the same as those obtained for the new sample to be tested, can be known by the ratio and/or the internal/external insertion method. The moisturizing component in the sample is measured as to how much glycerin is contained, and/or the moisturizing effect of the moisturizing component in the new sample to be tested, which corresponds to how much glycerin is expressed. Or, by the method described in the above embodiment, the actual vaporization amount of the vaporizable substance in the new sample to be tested is obtained.

That is, the present invention provides a detection method for knowing the amount of glycerin and/or effect corresponding to the moisturizing component in the new sample to be tested, which includes the following steps: providing a sample to be tested; Measuring a change amount of one of the electrical properties of the sample to be tested; providing a reference change amount, the reference change amount representing a concentration of a reference substance; comparing the change amount and the reference change amount to know the The sample to be tested contains the equivalent of the reference substance.

Please refer to the sixth figure, which is an embodiment of a device 60 for detecting the amount of vaporization of a sample. In the device 60 of the sixth figure, the control unit 61, the lock-in amplifier 62, the switching circuit 63 and the wafer 64 are included, wherein the members are coupled to each other, and the wafer 64 includes the receiving portions 641 and 642. Further, the bottoms of the accommodating portions 641 and 642 are individually provided with electrodes. Therefore, when the accommodating portion 641 or 642 is provided with a sample to be tested, the cross-sectional view thereof is as shown in the first (A) diagram. That is, the wafer 64 is configured with one to several devices as shown in the first (A) diagram.

The device 60 in the sixth figure detects the vaporization state/vaporization amount of the sample to be tested by measuring the electrical impedance value of the sample to be tested loaded in the measurement receiving portion 641 or 642. In detail, the impedance of the sample to be tested has DC and AC impedance, and the DC impedance can only measure the DC characteristics of the object to be measured, so the resistance characteristic (size) of the impedance can only be measured. The AC impedance can measure the capacitance characteristics of the object to be tested (including the size and phase angle). Measuring the AC impedance of the test object generally uses a lock-in amplifier, which uses a modulation technique to measure the frequency response (size and phase angle) of the object to be tested. The lock-in amplifier only measures the same signal as the measurement frequency, while ignoring the signal different from the measurement frequency. This feature also allows the lock-in amplifier to measure the signal with severe noise interference. The principle of the lock-in amplifier is as follows:

Each symbol is a table Vs: the size of the signal to be tested; Vr: reference signal size; LPF: low pass filter; I: in-phase part; Q: out-phase part; w: angular frequency; t: time; and θ _s : The phase angle difference between the signal to be tested and the reference signal.

By (3) (4) two-way cubic program, you can solve:

The in-phase voltage value and the out-of-phase voltage are measured by a lock-in amplifier to calculate the electrical impedance and capacitive reactance. In an AC RC circuit, the total impedance includes a portion of the electrical impedance R and a portion of the capacitive reactance X _C . The voltage through the capacitor will be 90° behind the current, which can be expressed as a complex plane as shown in Equation 7: Z=R- j X _C (Equation 7)

According to the partial pressure theorem, the impedance of the measured object in series with the current limiting resistor is estimated. The electrical impedance and the capacitive reactance can be expressed as (Equation 8). Among them, R ₀ : 1MΩ current limiting resistor, V ₀ : 1V reference signal, V _X : phase voltage measurement value, V _Y : phase voltage measurement value.

R = R ₀ (V _X / V ₀ ) X _C = R ₀ (V _Y / V ₀ ) (Formula 8) Further, the wafer 64 may be made of ITO glass as a base material. The ITO glass is coated on a mother glass substrate which is not electrically conductive, and is coated with a uniform transparent and electrically conductive indium tin oxide, which has characteristics such as conductivity, chemical stability, high visible light transmittance, and high infrared reflectance.

The preparation flow of the wafer 64 is briefly described below. A mother glass substrate is plated with a layer of ITO, and a photoresist layer is further coated on the ITO layer by spin coating. Then, after the photoresist layer is covered with a photomask, the photoresist layer is exposed, and the photoresist layer is removed by a developing process. Finally, after etching and demolding/cleaning, a wafer with an appropriate ITO electrode can be obtained.

The accommodating portions 641 and 642 on the wafer 64 can be formed by attaching a reusable enamel lattice to the wafer 64. The silicone gel is suitable for attaching to a smooth surface and is chemically stable and can be repeatedly cleaned, repetitively autoclaved and reusable. The number of grids of the capsules can be set to one or more grids depending on the requirements.

In the device 60, the switching circuit 63 is a signal switching circuit (Switch Box) directly connected to the chip 64, and the control unit 61 controls the switching circuit 63 to specify which one of the substrates 64 is to be detected. To achieve the function of automatic parallel detection of multiple samples.

In addition, the lock-in amplifier 61 provides an AC signal of 1 V through a 1 M Ω current limiting resistor to the switching circuit 63, and the control unit 61 controls which of the sensing portions in the housing is to be detected. The reference AC signal is connected in series to the sample to be tested in the accommodating portion through a 1 M Ω resistor, and then grounded, and then the phase-locked amplifier 61 measures the phase voltage and the phase voltage at both ends of the sample to be tested. Finally, according to the partial pressure theorem of the above formula 8, the electrical impedance value and the capacitance resistance value of the sample to be tested in the series circuit can be estimated.

In the part of the control unit 61, the ^LabVIEWTM (National Instrument Co., TX, USA) software can be used to compile the control program, and the lock-in amplifier 62 is connected through the computer RS-232 interface for parameter control, programmatic measurement, data acquisition, and The data is recorded and the switching circuit 63 is indirectly controlled by the digital output 埠 of the lock-in amplifier 62.

Through the apparatus 60 of the sixth figure, the plurality of samples to be sampled are subjected to automatic parallel detection, and further calculations are performed to obtain the results as shown in the third (B) or fourth (B) diagrams. Of course, the device 60 can detect the moisturizing effect (and the amount of vaporization) of different moisturizing ingredients.

The above-mentioned accommodating portions 641 and 642 can be disposed on the same wafer as needed, or can be respectively disposed on different wafers. In addition, the device 60 can simultaneously detect a plurality of wafers (each of which contains one or more accommodating portions) to achieve a plurality of parallel continuous measurement of the sample vaporization amount/moisturizing effect.

It should be further noted that the vaporizable substance in each of the above embodiments may be water or an organic solvent or the like, and the sample to be tested may be a liquid, a solid or a mixture thereof. The so-called vaporization can command hair, boiling, sublimation or any combination thereof.

Further, the electric resistance change amount (ohm/hr) in each of the above embodiments is expressed in hours, but the time unit can be replaced with any unit time (such as seconds, minutes, days, etc.). Moreover, the amount of electrical impedance change in each of the above embodiments may also be the difference of the electrical impedance values measured at any two different time points after the start of detection.

While the above embodiments use electrical impedance as the electrical property to reflect the amount of vaporization, the electrical properties that reflect the amount of vaporization, such as resistance, current, capacitive reactance, electrical impedance, or any combination thereof, should be It.

In particular, the illustrative embodiments set forth below may provide a clearer description of the invention:

A measuring system comprising: a first electrode; a first sample to be tested, comprising a first vaporizable substance, wherein the electrode is in contact with the first sample to be tested to measure the first to be tested a first electrical property of the sample during a first measurement period, and the first vaporizable material has a first vaporization amount vaporized from the first sample to be tested during the period; a second electrode And a second sample to be tested, comprising a second vaporizable substance, wherein the electrode is in contact with the second sample to be tested to measure the second sample to be tested in a second measurement period An electrical property, and the second vaporizable material has a second vaporization amount vaporized from the second sample to be tested during the period.

2. The system of embodiment 1, further comprising a control unit coupled to the first electrode and the second electrode for controlling when to measure the first electrical property and the second electrical The first electrode and the second electrode are disposed on the same wafer or on different wafers.

A method for detecting vaporization properties of a sample, comprising the steps of: providing a sample to be tested comprising a vaporizable substance; and measuring an electrical property of the sample to be tested during a measurement period to detect Measuring the vaporizable material in the amount One vaporization amount is vaporized from the sample to be tested during the measurement period.

4. The method of embodiment 3, further comprising: measuring the electrical property of the sample to be tested at least twice during the measuring period to obtain a first value of the electrical property and a first And determining, by the first value and the second value, the vaporization amount of the vaporizable substance vaporized from the sample to be tested during the measurement period.

5. The method of embodiment 4, wherein the vaporizable substance is vaporized from the sample to be tested during the measurement period by the difference between the first value and the second value. the amount.

6. The method of any of embodiments 3 to 5, wherein the electrical property is an electrical impedance.

7. A method for continuously detecting a sample vaporization amount, comprising the steps of: providing a sample to be tested comprising a target substance; and measuring an electrical property of the sample to be tested during every interval to detect the A vaporization amount is vaporized from the sample to be tested within the target substance.

8. A measurement system comprising: an electrode; and a sample to be tested, comprising a target substance, wherein the electrode is in contact with the sample to be tested to measure one of the samples to be tested during a measurement period An electrical property, and the target substance has a vaporization amount vaporized from the sample to be tested during the period.

9. The system of embodiment 8 wherein the sample to be tested is selected from the group consisting of One of a group consisting of a liquid, a solid, and a combination thereof.

10. A method of detecting vaporization of a sample, comprising the steps of: providing a sample to be tested comprising a target substance; and measuring an electrical property of the sample to be detected to detect the target substance from the test One of the samples is vaporized.

A detection method comprising the steps of: providing a sample to be tested; measuring a change in one of electrical properties of the sample to be tested during a measurement period; providing a reference change amount, the reference change amount Representing a concentration of a reference substance; and comparing the amount of the change with the amount of the reference change to know how much the reference substance is contained in the sample to be tested.

As can be seen from the above description, the embodiment of the present invention does provide an apparatus and method for rapidly and automatically detecting the vaporization amount of a vaporizable substance in a sample and/or the moisturizing effect of the sample. Through these devices and methods, not only can the corresponding vaporization amount of a plurality of samples be continuously recorded in parallel, but the sensitivity and accuracy are excellent, and individual samples can be detected only by a very small amount (for example, 0.1 mL). These advantages can significantly reduce the cost of testing the moisturizing effect of the sample.

It is to be noted that the present invention has been described in detail by the above examples, and may be modified by those skilled in the art without departing from the scope of the embodiments.

10‧‧‧Test samples

101‧‧‧ end face

11‧‧‧Electrode

111‧‧‧Measurement surface

12‧‧‧ interval

60‧‧‧ device

61‧‧‧Control unit

62‧‧‧Lock-in amplifier

63‧‧‧Switching circuit

64‧‧‧ wafer

641, 642‧‧‧ 容 部

The first (A) and (B) diagrams are schematic diagrams of embodiments for detecting vaporization.

The second figure is a schematic diagram showing the relationship between the change of the electrical impedance value and the time.

The third (A) and third (B) graphs show the amount of vaporization or resistance change per hour of water, respectively, and the third (C) graph shows the vaporization rate of various glycerol relative to water.

The fourth (A) and fourth (B) graphs show the hourly vaporization amount or the electrical impedance change amount of water, respectively, and the fourth (C) graph shows the vaporization rate of various contents of hyaluronic acid relative to water.

The fifth figure is an inductive graph of the vaporization rate of water with a sample containing glycerin and hyaluronic acid measured by electrical impedance method in the third (C) and fourth (C) diagrams, respectively.

The sixth figure is an example of detecting the amount of vaporization.

Claims (2)

A system for measuring vaporization of a sample, comprising: a first electrode; a first sample to be tested, comprising a first vaporizable substance, wherein the first electrode is in contact with the first sample to be measured to measure the first a first electrical property of the sample to be tested during a first measurement period, and the first vaporizable material has a first vaporization amount vaporized from the first sample to be tested during the period, wherein The first vaporization amount is obtained by the first electrical property; a second electrode; and a second sample to be tested, comprising a second vaporizable substance, wherein the second electrode is in contact with the second sample to be tested Measure a second electrical property of the second sample to be tested during a second measurement period, and the second vaporizable substance has a vaporization from the second sample to be tested during the period a second vaporization amount, wherein the second vaporization amount is derived from the second electrical property, and comparing the first vaporization amount with the second vaporization amount to evaluate the first sample to be tested compared to the first The vaporization rate and/or moisturizing effect of the sample to be tested. The system of claim 1, further comprising a control unit coupled to the first electrode and the second electrode for controlling when to measure the first electrical property and the second electrical The first electrode and the second electrode are disposed on the same wafer or on different wafers.