TWI486183B - Method for preventing odor of medicine containing olmesartan medoxomil - Google Patents

Description

Odor prevention method containing olmesartan medoxomil preparation

The present invention relates to a blister pack or a blister pack relating to a packaging material containing an odor sorbent and a packaged pharmaceutical product.

When packaging pharmaceuticals, packaging (PTP) or blister packaging is widely used, but some of the pharmaceutical products have the odor of the preparation, and the staff of the medical equipment that implements the blister or blister packaging often The smell is uncomfortable. Moreover, the user feels uncomfortable with the odor when taking the tablet from the blister pack or the blister pack or when taking it. Such formulations result in reduced compliance of the user and affect the value of the product.

In the packaging form of a blister pack or a blister pack of a pharmaceutical product, the method of adsorbing the odor emitted by the preparation is to seal the blister pack or the blister pack with a high gas-shielding aluminum laminate sheet (hereinafter referred to as "Pillow packaging"), in which an odor adsorbent is incorporated, absorbs a slight odor by a blister pack or a blister pack. However, in order to ensure the hygiene of the preparation and the stability of the preparation for a long period of time, the foam packaging or the blister packaging usually selects a packaging material having a high airtightness, so that the odorous substance remains in the bag of the blister pack or the blister pack. The effect of suppressing odor is insufficient. There is a deodorant film material in which the zeolite is uniformly dispersed and mixed in a film material (Japanese Laid-Open Patent Publication No. Hei 11-35077), and there is no packaging material for a package containing the specific drug of the present invention.

Patent Document 1: Japanese Patent Publication No. 11-35077

The object of the present invention is to provide an adsorption by containing olmesartan Medoxomil or 2-amino-5-isobutyl-4-{2-[5-(N,N'-bis((S)-) A packaging material for an odorous substance produced by the preparation of 1-ethoxycarbonyl)ethyl)phosphine decylamine]furanyl}thiazole.

As a result of intensive research to accomplish the above object, the present inventors have found that the packaging material contains an odor adsorbent, and the packaging material is adsorbed by containing olmesartan medoxomil or 2-amino-5-isobutyl-4-{2 -[5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphoniumamine]furanyl}thiazole produces an odorous substance to lower its gas concentration, thereby preventing or reducing The odor feeling at the time of taking out the preparation of the package body can reduce the discomfort and complete the present invention.

That is, the present invention provides (1) a packaging material characterized by packaging a packaging material containing olmesartan medoxomil and containing an odor adsorbent, and (2) a packaging material according to item (1). The odor adsorbent is one or more selected from the group consisting of a physical adsorbent and a chemical adsorbent. (3) The packaging material according to item (1), wherein the odor adsorbent is selected from the group consisting of (1) A packaging material according to the item (1), wherein the odor adsorbent is a synthetic zeolite 13X, and (5) is packaged according to the item (1). The odor adsorbent is a hydrophobic zeolite, (6) the packaging material according to the item (1), wherein the odor adsorbent is a hydrophobic zeolite which is subjected to hydrophobic treatment to the synthetic zeolite 13X. (7) The packaging material according to the item (1), wherein the odor adsorbent is a sorghum zeolite, (8) the packaging material according to any one of (1) to (7), wherein the packaging material is a multilayer film. (9) The packaging material according to item (8), wherein the multilayer film has an adsorption layer containing a odor adsorbent and a substrate layer, (10) a packaging material according to item (9), wherein the adsorption layer and (11) A packaging material according to item (9) or (10), wherein a side of the adsorption layer opposite to the substrate layer further has a sealant layer, (12) The packaging material according to any one of the items (9), wherein the side of the adsorption layer in contact with the substrate layer further has an outer layer, (13) according to any one of items (9) to (12) a packaging material, wherein the adsorption layer comprises a material selected from the group consisting of low density polyethylene, linear low density polyethylene, polypropylene, ionomer, ethylene acrylic acid copolymer, ethylene methacrylic acid copolymer, ethylene vinyl acetate copolymer And one or more of the compounds of ethylene vinyl acrylate copolymer, ethylene methyl acrylate copolymer, and ethylene methyl methacrylate copolymer, (14) according to any one of items (9) to (12) item The packaging material, wherein the adsorption layer contains one or more selected from the group consisting of low density polyethylene, linear low density polyethylene, and polypropylene, and (15) as in items (9) to (12). The packaging material according to any one of the items (9) to (15), wherein the substrate layer is selected from the group consisting of polychlorinated materials. Ethylene, non-ducted polypropylene, polypropylene, polyposition A packaging material according to any one of the items (9) to (15), wherein the base material is one or more of the compounds of the above-mentioned (9) to (15). The packaging material of any one of (10) to (17), wherein the adhesive layer is selected from the group consisting of low density polyethylene, linear low density polyethylene, (1) The packaging material according to any one of (10) to (17), wherein the adhesive layer contains a low density polyethylene, and (20) is as The packaging material according to any one of the items of the present invention, wherein the sealant layer contains one or more selected from the group consisting of low density polyethylene, linear low density polyethylene, and polypropylene. (21) A packaging material according to any one of items (11) to (19), wherein the sealant layer contains a linear low-density polyethylene, and (22) as in any of items (12) to (21) A packaging material, wherein the outer layer contains one or more selected from the group consisting of low density polyethylene, linear low density polyethylene, and polypropylene, and (23) as in (12) to (21) The packaging material of any of the items, wherein the outer layer A linear low-density polyethylene, (24) a blister pack or a blister pack, which is a packaging material according to any one of items (1) to (23), (25) a blister pack Or a blister pack, which is attached to the pocket sheet of the container, using the packaging material according to any one of items (1) to (23), (26) A blister pack or blister pack according to item (24) or (25), which comprises a preparation containing olmesartan medoxomil, (27) a preparation containing olmesartan medoxomil, which is A packaging material according to any one of (1) to (23), (28) a preparation containing olmesartan medoxomil, which is in a blister pack or blister as in item (24) or (25) Packaging for packaging, (29) A method for preventing odors containing a formulation of olmesartan medoxomil, characterized by packaging according to any one of items (1) to (23), (30) one containing A method for preventing odor of a valsartan ester preparation characterized by being packaged in an blister pack or a blister pack as in item (24) or (25).

Still from another viewpoint, the present invention provides (31) a packaging material which is suitable for containing 2-amino-5-isobutyl-4-{2- in the items (1) to (23). [5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphoniumamine]furanyl}thiazole formulation replaces the packaging material containing the formulation of olmesartan medoxomil, (32) An blister pack or blister pack, which is used in items (24) through (26), and is suitable for containing 2-amino-5-isobutyl-4-{2-[5-(N,N' - a preparation of bis((S)-1-ethoxycarbonyl)ethyl)phosphoniumamine]furanyl}thiazole in place of a blister pack or blister pack containing a formulation of olmesartan medoxomil, (33) a preparation In item (27) or (28), suitable for containing 2-amino-5-isobutyl-4-{2-[5-(N,N'-bis((S)-1-) An ethoxycarbonyl)ethyl)phosphine decylamine]furanyl}thiazole formulation replaces a formulation containing an olmesartan medoxomil formulation, (34) A method for preventing odor, which is suitable for containing 2-amino-5-isobutyl-4-{2-[5-(N,N) in the item (29) or (30) The '-bis((S)-1-ethoxycarbonyl)ethyl)phosphoniumamine]furanyl}thiazole formulation replaces the odor prevention method containing the olmesartan medoxomil preparation.

By using the packaging material containing the odor absorbing agent of the present invention, it is possible to provide a package which hardly feels odor when the preparation is taken out.

[Best form of implementing the invention]

The packaging material of the present invention contains an odor adsorbent. The package of the packaging material of the present invention can absorb the odor generated by the preparation.

The odor adsorbent used in the present invention, for example, a physical adsorbent such as synthetic zeolite, tannin, alumina, activated carbon, or a compound chemical deodorant based on an organic acid (Daimushen) can be used with an odor. The chemical adsorbent for chemically adsorbing the substance, etc., is preferably a synthetic zeolite, particularly preferably a hydrophobic zeolite, and particularly preferably a sorghum zeolite. Due to the adsorption rate and adsorption characteristics of the odorous substance, a physical adsorbent and a chemical adsorbent may be used in combination.

The synthetic zeolite is a porous granular material for separating substances according to a different molecular size, has a uniform pore structure, and adsorbs small molecules that enter the pore cavity to perform a sieving action. The adsorption pore diameter in the present invention is preferably from 0.3 nm to 1 nm. The synthetic zeolite having a pore diameter of about 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm is referred to as synthetic zeolite 3A, synthetic zeolite 4A, synthetic zeolite 5A, and synthetic zeolite 13X, respectively. Among them, synthetic zeolite 13X having a pore diameter of about 1 nm is particularly preferable.

The average particle diameter of the synthetic zeolite is not particularly limited, and the present invention can be completed. The purpose is, for example, a particle size of about 10 μm. Further, the adsorption characteristics of the synthetic zeolite are related to the pore diameter, and in order to improve the odor absorption characteristics, by making the powder of the synthetic zeolite finer, the surface area can be practically increased, and the number of pores can be increased.

Hydrophobic zeolite refers to a synthetic zeolite that is subjected to hydrophobic treatment. The synthetic zeolite has an adsorption odor and a moisture absorbing ability, and the more the moisture absorption, the lower the adsorption performance of the odor, so that the synthetic zeolite which is subjected to hydrophobic treatment to suppress the moisture absorbing ability is particularly preferable. A method of subjecting the synthetic zeolite to a hydrophobic treatment, for example, a method of adsorbing a surfactant to a zeolite or a method of reacting a decylating agent with a hydroxyl group on the surface of a zeolite, or a method of performing a dealumination treatment.

The sorghum zeolite refers to a synthetic zeolite which reduces aluminum atoms in the crystal framework of the synthetic zeolite by dealuminization treatment and increases the cerium oxide/alumina ratio (SiO ₂ /Al ₂ O ₃ ratio). By the dealumination treatment, the synthetic zeolite can be deprived of affinity for polar substances such as water, and a nonpolar substance such as an odor substance can be more strongly adsorbed. Among them, a high cerium zeolite having a ceria/alumina ratio of 5 or more is particularly preferable. As such a sorghum zeolite, for example, ABSCENT manufactured by Union Co., Ltd., or HSZ series manufactured by Tosoh Corporation can be used.

The packaging material of the present invention may be a resin such as a thermoplastic resin, paper, fiber, metal, various coating materials, various kinds of adhesives, etc., and is preferably a thermoplastic resin.

The thermoplastic resin is not particularly limited, and those known to use, for example, polyvinyl chloride (PVC), non-stretched polypropylene (CPP), polypropylene (PP), polyvinylidene chloride (PVDC), polychlorotrifluoride can be used. Ethylene (PCTFE), cyclic olefin copolymer (COC), polyethylene (PE), polycarbonate (PC), polyamine (PA), ethylene-vinyl acetate copolymer (EVA), ethylene-methacryl Acid ester copolymer, polystyrene (PS), polyester (PET), polyacrylic acid (PAA), etc., preferably polyvinyl chloride, non-stretched polypropylene, polypropylene, polyvinylidene chloride, polychlorotrifluoride Ethylene or cyclic olefin copolymer. In the present invention, these may be used alone or in combination of two or more.

The packaging material of the present invention is not limited to a single layer, and may be a multilayer film in which a plurality of layers are bonded. The type, amount, thickness, and number of layers of the multilayer film are not particularly limited, and may be widely used as long as the object of the present invention is completed, and are appropriately selected depending on the use.

As shown in Fig. 1, the multilayer film 1 of the present invention has an adsorption layer 2 containing an odor adsorbent as an inner layer, and a base layer (barrier layer) which is prevented from moisture and oxygen and which enters from the outside air as an outer layer. ) 3.

The resin to be used for the adsorption layer is not particularly limited, and can be appropriately selected by a user, and is preferably a resin having a high melt flow rate, a low melting point (low softening point), and excellent low-temperature shrinkability. In the case of a high melt flow rate resin, even if the melt flow rate is lowered by the addition of the adsorbent, a certain degree of flow characteristics can be maintained. If it is a low melting point, the resin softens at a low temperature, can be extruded at a low temperature, and can prevent foaming. In the case of a resin excellent in low-temperature shrinkability, it is easy to carry out extrusion molding by an extrusion molding machine even if an adsorbent is added. Among them, a resin having a melt flow rate of 10 or more and a low melting point and excellent in low-temperature shrinkage is particularly preferable.

From this point of view, resins used for the adsorption layer such as low density polyethylene (LDPE), linear low density polyethylene (LLDPE), polypropylene (PP), various copolymers (copolymers) such as ionomers (for example Salt of ethylene acrylic acid copolymer), ethylene acrylic acid copolymer (EAA), ethylene methacrylic acid copolymer (EMAA), ethylene vinyl acetate copolymer (EVA), B The methacrylic acid methyl ester copolymer (EMA), the ethylene methyl methacrylate copolymer (EMMA), and the like are preferably low density polyethylene, linear low density polyethylene, polypropylene, and particularly low density polyethylene. In the present invention, these may be used alone or in combination of two or more.

In the adsorption layer, other pigments may be blended as needed. As the pigment other than the odor absorbing agent, a pigment which does not particularly have hygroscopic property or gas adsorbing property can be used, and if it contains a functional pigment, it has various recombination effects. Such pigments are, for example, synthetic zeolites, calcium chloride, calcium oxide, calcium carbonate, titanium oxide, zinc oxide, zirconium oxide, aluminum oxide, cerium oxide, mica, talc, carbon, activated carbon and the like, and are preferably synthetic zeolites.

The content of the odor adsorbent in the adsorption layer is, for example, 5 to 70% by weight, preferably 10 to 60% by weight. When the other pigment is contained in addition to the odor absorbent, the content of the total pigment is, for example, 30 to 70% by weight, preferably 45 to 65% by weight.

The film thickness of the adsorption layer is not particularly limited, but may be accomplished by the object of the present invention, for example, 10 μm to 200 μm, preferably 30 μm to 100 μm.

The resin used for the substrate layer can block the entry of moisture and oxygen from the outside, and can be used without any particular limitation, such as polyvinyl chloride, non-ductile polypropylene, polypropylene, polyvinylidene chloride. , polychlorotrifluoroethylene, cyclic olefin copolymer, polyethylene, polycarbonate, polyamide, ethylene-vinyl acetate copolymer, ethylene methacrylate copolymer, polystyrene, polyester, polyacrylic acid Etc., it should be polyvinyl chloride, non-stretched polypropylene, polypropylene, polyvinylidene chloride, polyethylene terephthalate, especially polyvinyl chloride. In the present invention, these substances may be used alone or in combination of two kinds. Use above.

The thickness of the substrate layer is not particularly limited, and the object of the present invention can be achieved, for example, 20 μm to 400 μm, preferably 50 μm to 300 μm.

An adhesive layer may be further contained between the adsorption layer and the substrate layer. The adhesive layer is, for example, low density polyethylene, linear low density polyethylene, polypropylene or the like, and is preferably low density polyethylene. In the present invention, these may be used alone or in combination of two or more.

The method of bonding the adsorption layer and the substrate layer, such as extrusion lamination, dry lamination, wet lamination, thermal lamination, sand lamination, etc., is preferably dry lamination or sand lamination. Extrusion lamination refers to a method in which a molten resin is thinly flowed onto a substrate from a T-die and rolled and rolled. The dry lamination method refers to a method of bonding a substrate to a preformed thermoplastic resin film or the like, applying an adhesive to a substrate, drying the adhesive in a heating drying oven, and then laminating the film to perform rolling calendering. method. Wet lamination is different from dry lamination and refers to a method of bonding a substrate to a film without drying the adhesive. The heat lamination is a method in which a preformed thermoplastic resin film is superposed on a substrate and heated and rolled by a heat roller. Sand lamination refers to a method in which two base materials are taken out, a molten resin is extruded from a T die, and flows between two substrates to be rolled by rolling and adhering.

The thickness of the obtained multilayer film is not particularly limited, and the object of the present invention can be achieved, for example, 30 μm to 500 μm, preferably 100 μm to 400 μm.

As shown in Fig. 2, in the other multilayer film 1 of the present invention, the absorbing layer 2 may further include the outer layer 4 on the side of the main adsorption layer 2a which is in contact with the substrate layer 3, or may be opposed to the substrate layer 3. The main adsorption layer 2a side further contains a sealant layer 5. In order to sandwich the main adsorption layer which mainly adsorbs odor, it may also contain auxiliary adsorption. A sub-adsorption layer of odor. When the adsorption layer is formed by the main adsorption layer and the sub-adsorption layer, the content of the adsorbent in the main adsorption layer is preferably more than the content in the sub-adsorption layer. Thereby, the efficiency of adsorption can be improved.

The sealant layer such as low density polyethylene, linear low density polyethylene, polypropylene or the like is preferably a linear low density polyethylene. In the present invention, these may be used alone or in combination of two or more.

The outer layer such as low density polyethylene, linear low density polyethylene, polypropylene or the like is preferably a linear low density polyethylene. In the present invention, these may be used alone or in combination of two or more.

The adsorption layer is formed into a film or a sheet by a blown film method, a T-die method, co-extrusion or the like to form a film or a sheet, and is preferably a multilayer film formed by a blown film method. Further, the multilayer blown film method is a method of producing a multilayer film by extruding a molten resin into a tubular shape by a plurality of extruders, and sending air therein to expand. The structure of the adsorption layer is preferably two kinds of three layers or three kinds of three layers formed by the outer layer/main adsorption layer/seal layer.

The blister pack or blister pack can be made using the packaging material of the present invention, and the preparation can be packaged. As shown in Fig. 3, the embossed package 8 of the present invention is composed of a multilayer film 1 (bag-attached sheet) containing a bag portion of the preparation preparation 7, and a cover member 6 for sealing the bag portion. The bag-type sheet has a plurality of concave pocket portions of the collection preparation 7, and the preparation 7 is stored in the bag portion.

The preparation packaged in a blister pack or a blister pack, such as a tablet, a capsule, a powder, a fine granule, a granule, a tablet, etc., is preferably a tablet.

In a blister pack or blister pack, it is preferred to include a sealant layer on the side in contact with the formulation of the package. By containing a sealant in the innermost layer of the multilayer film The layer, the sealant layer, is a layer that is heat sealed to the cover material and prevents the formulation from coming into direct contact with the adsorbent layer.

A cover material such as a laminate film of aluminum foil, aluminum foil, and plastic film.

The method for producing a foamed package or a blister package according to the present invention can be used such as "medical product-food packaging design, representation, material specification, quality assurance of packaging engineering (Technical Information Association, issued on September 1, 2005) It is manufactured by the general method described in the publication, and there is no particular limitation.

In the present invention, the active ingredient contained in the preparation may be a drug containing an odor, and is not limited to its structure and degree, such as olmesartan medoxomil, 2-amino-5-isobutyl-4-{2 -[5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphoniumamine]furanyl}thiazole, L-cysteine, DL-methylthiobutyric acid, Bucillamine, methyl sulphate only sulphide chloride, ethyl cysteine hydrochloride, Bacampicillin Hydrochloridel, cephalosporin, sulinmicillin tosilate, Sulfur-containing compounds such as Diclofenamide, Ranitidine, Famotidine, Nizatidine, olmesartan medoxomil, Dindolol, C Sodium valerate, acetamidine hydrochloride (Todralazine Hydrochloride), toluidine hydrochloride, trimethylcyclodiketone, salazosulfapyridine, flurbiprofen, traditional Chinese medicine, herbal medicine and other drugs with special odor, preferably olmesartan medoxomil or 2 -Amino-5-isobutyl-4-{2-[5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphoniumamine]furanyl}thiazole. And olmesartan medoxomil is effective in diseases caused by hypertension or hypertension (more specifically, hypertension, heart disease [narrow heart disease, myocardial infarction, arrhythmia, cardiac insufficiency or cardiac hypertrophy], kidney disease The prevention or treatment of [diabetic nephropathy, glomerulonephritis or nephrosclerosis] or cerebrovascular disease [cerebral infarction or cerebral hemorrhage] can be carried out according to Patent License No. 2082519 (U.S. Patent No. 5,616,599). It is easy to manufacture by the method described. 2-Amino-5-isobutyl-4-{2-[5-(N,N'-bis((S)-1-ethoxycarbonyl)ethyl)phosphine decylamine]furanyl}thiazole It can be easily manufactured according to the method described in International Publication No. 01/47935 and the like.

Further, the preparation of the present invention may contain other active ingredients as needed. The active ingredient is, for example, a diuretic such as Trichloromethiazide, Hydrochlorothiazide or Benzylhydrochlorothiazide; Azelnidipine, Amlodipine, Beni Benidipine, Nitrendipine, Manidipine, Nicardipine, Nifedipine, Cilnidipine, Ainidipine ( Calcium blockers such as Efonidipine), Barnidipine, Felodipine, Pioglitazone, Rosiglitazone, Rivoglitazone, MCC-555, Insulin resistance improvers such as NN-2344, BMS-298585, AZ-242, LY-519818, TAK-559; Pravastatin, Simvastatin, Atorvastatin , Hels-CoA reductase inhibitors such as Rosuvastatin, Cerivastatin, Pitavastatin, Fluvastatin; SMP-797 ACAT inhibitors such as Pactimibe, etc., but are not limited thereto. The amount of these active ingredients is not particularly limited, and it can be used in an amount generally used for the preparation.

Hereinafter, the present invention will be described in more detail by way of examples, but the invention is not limited thereto.

(Example 1) (1) Adjustment of master batch containing odor sorbent

50 parts by weight of sorghum zeolite (trade name: ABSCENTS3000, manufactured by Showa Co., Ltd.) was kneaded and adjusted to a pelletized resin as a main compound (MB1).

(2) Production of adsorption layer

The following two types of three-layer films were produced according to the multilayer blown film method. The LDPE of MB1 and the base resin was blended at a ratio of 2:3, and the adsorbent content was 20% by weight. Only LLDPE was used in the outer layer and the sealant layer to prepare two kinds of three-layer adsorption layers, so that the layers were The film thickness is the outer layer/main adsorption layer/seal layer = 10 μm / 60 μm / 10 μm, which is the resin of the adsorption layer.

(3) Production of multilayer film

The LDPE was used as an adhesive layer by a sand lamination method, and the outer layer side of the above-mentioned adsorption film and polyvinyl chloride (manufactured by Sumitomo Beacont Co., Ltd.) having a thickness of 200 μm were laminated to prepare a multilayer film for embossing.

(4) Production of foaming packaging

The foam packaging was produced using the M2 type manufactured by CKD Corporation. The material of the blister pack is the above-mentioned multilayer film having an odor-absorbing function, and an aluminum foil (manufactured by Toyo Aluminum) having a thickness of 17 μm as a cover material, and filled with 10 tablets of olmesartan medoxomil (Omedek) per blister pack. (registered trademark) 20mg Ingot) preparation.

(Comparative Example 1)

The foam-free packaging of the non-stretched polypropylene was produced using the M2 type manufactured by CKD Corporation. The material of the blister pack is a non-extensible polypropylene (manufactured by Sumitomo Beclet Co., Ltd.) having a thickness of 250 μm, and an aluminum foil (manufactured by Toyo Aluminum) having a thickness of 17 μm as a cover material, and filled with 10 tablets of Omega sand per blister pack. Formulation of Tanthanum (Omedek (registered trademark) 20 mg ingot).

(Test Example 1) Functional test according to the odor tester

The measurement of the odor tester was carried out by producing a special container having a structure in which the odor at the time of taking out the tablet was immediately sealed and measured, and the content was 72 mL. Using this dedicated container and an odor tester (Portable Odor Meter FPO-1, manufactured by Futaba Electronics Co., Ltd.), the odor intensity when the olmesartan medoxomil-containing preparation was taken out from the blister pack was measured. The blister pack of the pillow-shaped sealed package and the blister pack (open) without the pillow-shaped sealed package are placed in a thermostatic bath at 25 ° C, and the pillow-shaped sealed package is opened one month later, and the odor tester is used for the measurement. The odor of the container was taken out from the blister pack at a time, and the result was as shown in Table 1.

As is apparent from the results of Table 1, the use of the embossed package of the packaging material of the present invention significantly reduces the odor when the tablet is taken out.

(Test Example 2) Functional test

The blister pack of the pillow-shaped sealed package or the blister pack (open) without the pillow-shaped sealed package shall be placed in a thermostatic bath at 40 ° C and 25 ° C, and the pillow-shaped sealed package shall be opened after 6 months, by functional test. To evaluate the odor when the tablet is taken out from the blister pack. The results are shown in Table 2.

(Functional Evaluation Benchmark)

Evaluation method 0: odorless, 0.5: very rare, 1: rare, 2: weak, 3: strong evaluation value = total value of the product reviewer / number of product evaluations (5)

As is clear from the results of Table 2, the embossed package of the present invention has no odor when the preparation is taken out in any of the storage states, and the odor absorption function can be maintained for a long period of time.

[The possibility of being applied to the industry]

According to the present invention, it is possible to provide a pharmaceutical package which hardly feels odor when the preparation is taken out.

1‧‧‧Multilayer film

2‧‧‧Adsorption layer

2a‧‧‧Main adsorption layer

3‧‧‧Substrate layer (barrier layer)

4‧‧‧ outer layer

5‧‧‧Seal layer

6‧‧‧Cover materials

7‧‧‧ preparation

8‧‧‧Voice packaging

Fig. 1 is a schematic cross-sectional view showing a multilayer film of the present invention.

Fig. 2 is another schematic cross-sectional view of the multilayer film of the present invention.

Figure 3 is a schematic cross-sectional view of the blister pack of the present invention.

Claims (13)

An odor preventing method comprising a olmesartan Medoxomil preparation characterized by being packaged in a multilayer film having an adsorption layer containing an odor adsorbent and a multilayer film comprising a polyvinyl chloride substrate layer Wherein the adsorption layer is an adsorption layer having a main adsorption layer and a sealant layer on a side opposite to the substrate layer, the main adsorption layer containing a low density polyethylene containing a synthetic zeolite as an odor adsorbent, the sealant layer Contains linear low density polyethylene. The odor preventing method containing the olmesartan medoxomil preparation according to the first aspect of the patent application, wherein the odor adsorbing agent is a synthetic zeolite 13X. The odor preventing method containing the olmesartan medoxomil preparation according to the first aspect of the patent application, wherein the odor absorbing agent is a hydrophobic zeolite. The odor-preventing method containing the olmesartan medoxomil preparation according to the first aspect of the invention, wherein the odor-adsorbing agent is a hydrophobic zeolite which is subjected to hydrophobic treatment to the synthetic zeolite 13X. The odor preventing method containing the olmesartan medoxomil preparation according to the first aspect of the patent application, wherein the odor adsorbent is sorghum zeolite. The odor preventing method containing the olmesartan medoxomil preparation according to the first aspect of the patent application, wherein an adhesive layer is further provided between the adsorption layer and the substrate layer. The odor preventing method containing the olmesartan medoxomil preparation according to claim 6, wherein the adhesive layer contains one selected from the group consisting of low density polyethylene, linear low density polyethylene, and polypropylene. Or two or more. Such as the odor prevention of the olmesartan medoxomil preparation according to item 6 of the patent application scope A method in which the adhesive layer contains low density polyethylene. The odor preventing method containing the olmesartan medoxomil preparation according to the first aspect of the invention, wherein the adsorbing layer side in contact with the substrate layer further has an outer layer. The odor preventing method containing the olmesartan medoxomil preparation according to claim 9, wherein the outer layer contains one selected from the group consisting of low density polyethylene, linear low density polyethylene, and polypropylene. 2 or more types. A method for preventing odor containing an olmesartan medoxomil formulation according to claim 9 wherein the outer layer contains a linear low-density polyethylene. The odor preventing method containing the olmesartan medoxomil formulation according to any one of claims 1 to 11, which is packaged in a blister pack or a blister pack using the multilayer film. A method for preventing odor containing an olmesartan medoxomil formulation according to any one of claims 1 to 11, which is used for a pouch pack or a bubble of the multilayer film of a pocket sheet of a container. Cover the package for packaging.