TWI484993B - Device for breaking up magnetic droplet - Google Patents
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Description
本提案係關於一種液滴處理設備，特別是用磁性液滴的分裂設備。This proposal relates to a droplet processing apparatus, particularly a splitting apparatus using magnetic droplets.
在一個自動化的實驗室晶片(lab on a chip)中，微小的磁性液滴可作為人工抗體篩選、疾病檢測或個人化用藥分子診斷時的一個載體單元。磁性液滴包含了微米或奈米等級的鐵磁性粒子(例如氧化鐵粒子)、表面活性劑(surfactant)與載基流體(例如油或水)。並且，由於磁性液滴具有順磁性，引此可藉由磁力來對磁性液滴進行多元的行為控制。In an automated lab on a chip, tiny magnetic droplets can serve as a carrier unit for artificial antibody screening, disease detection, or personalized molecular diagnostics. Magnetic droplets contain ferromagnetic particles (such as iron oxide particles), surfactants, and carrier-based fluids (such as oil or water) in micron or nanoscale. Moreover, since the magnetic droplets have paramagnetic properties, the magnetic droplets can be subjected to multiple behavioral control by magnetic force.
一般而言，微小的磁性液滴係由一體積較大的磁性母液滴透過分裂手段而產生。進一步來說，可在一個液滴儲存槽內存放磁性母液滴，並經由磁場控制而使磁性母液滴經過分裂設備而分裂出微小的磁性液滴。In general, tiny magnetic droplets are produced by a bulky magnetic mother droplet passing through a splitting means. Further, the magnetic mother droplets can be stored in a droplet storage tank, and the magnetic mother droplets are controlled by the magnetic field to split the minute magnetic droplets through the splitting device.
然而，要使微小的磁性液滴由磁性母液滴分裂出來的過程，是一個非常複雜地且多相的介面物理行為。因此，如何使每一微小的磁性液滴能夠均勻、快速且連續不斷地自磁性母液滴分裂產出，係為研究人員所欲追求的目標。However, the process of splitting tiny magnetic droplets from magnetic mother droplets is a very complex and multi-phase interface physical behavior. Therefore, how to make each tiny magnetic droplet can be split from the magnetic mother droplet uniformly, quickly and continuously is the goal that researchers are pursuing.
本提案在於提供一種磁性液滴處理設備，藉以使微小的磁性液滴能夠均勻、快速且連續不斷地分裂產出。The proposal is to provide a magnetic droplet processing apparatus whereby minute magnetic droplets can be split uniformly, quickly and continuously.
本提案所揭露之磁性液滴處理設備，用以將一磁性母液滴分 裂出一磁性子液滴。磁性液滴處理設備包含一分裂器及一時序性磁場產生器。分裂器包含一本體及一基板。本體具有一表面，表面向下凹陷而形成一第一凹槽、一第二凹槽以及介於第一凹槽及第二凹槽的一溝槽，溝槽連接第一凹槽及第二凹槽。基板貼合於表面，以令第一凹槽、第二凹槽及溝槽對應形成一第一腔室、一第二腔室及連通第一腔室及第二腔室的一流道。第一腔室用以容置磁性母液滴。時序性磁場產生器包含多個磁性元件，這些磁性元件沿著流道的延伸方向而依序排列。這些磁性元件隨著時間而改變磁極，以驅使磁性母液滴朝流道前進，令磁性母液滴的部份體積擠壓進入流道後而分裂出磁性子液滴至第二腔室。The magnetic droplet processing apparatus disclosed in the proposal for dividing a magnetic mother droplet A magnetic droplet is broken out. The magnetic droplet processing apparatus includes a splitter and a sequential magnetic field generator. The splitter includes a body and a substrate. The body has a surface, the surface is recessed downward to form a first groove, a second groove and a groove between the first groove and the second groove, the groove connecting the first groove and the second concave groove. The substrate is attached to the surface such that the first groove, the second groove and the groove correspondingly form a first chamber, a second chamber and a first-class channel connecting the first chamber and the second chamber. The first chamber is for receiving magnetic mother droplets. The time-series magnetic field generator includes a plurality of magnetic elements which are sequentially arranged along the extending direction of the flow path. These magnetic elements change the magnetic poles over time to drive the magnetic mother droplets toward the flow path, causing a portion of the magnetic mother droplets to squeeze into the flow channels and split the magnetic droplets into the second chamber.
根據上述本提案所揭露之磁性液滴分裂設備，係藉由時序性磁場產生器產生時序性的磁場，以同時對磁性母液滴施以一吸力及一斥力而驅使磁性母液滴朝流道前進，以令磁性母液滴的部份體積擠壓進入流道後而分裂出磁性子液滴。如此，使磁性母液滴能夠均勻、快速且連續不斷地分裂產出磁性子液滴。According to the magnetic droplet splitting device disclosed in the above proposal, the sequential magnetic field is generated by the sequential magnetic field generator to simultaneously apply a suction force and a repulsive force to the magnetic mother droplet to drive the magnetic mother droplet toward the flow path. The magnetic sub-droplets are split after the partial volume of the magnetic mother droplets is squeezed into the flow path. In this way, the magnetic mother droplets can be split uniformly, rapidly and continuously to produce magnetic droplets.
有關本提案的特徵、實作與功效，茲配合圖式作最佳實施例詳細說明如下。The features, implementation and efficacy of this proposal are described in detail below with reference to the preferred embodiment of the drawings.
請參照第1圖至第3圖，第1圖係為根據本提案一實施例之磁性液滴處理設備的結構示意圖，第2圖係為根據第1圖之分裂器的結構分解圖，第3圖係為根據第1圖之磁性液滴處理設備的側視圖。Please refer to FIG. 1 to FIG. 3 . FIG. 1 is a schematic structural view of a magnetic droplet processing apparatus according to an embodiment of the present proposal, and FIG. 2 is an exploded view of the splitter according to FIG. 1 , and a third The figure is a side view of the magnetic droplet processing apparatus according to Fig. 1.
本提案之磁性液滴處理設備10，係用以將一磁性母液滴以連 續且均勻的方式分裂出多個磁性子液滴。磁性液滴處理設備10包含一分裂器11及一時序性磁場產生器12。The magnetic droplet processing apparatus 10 of the present proposal is for connecting a magnetic mother droplet A plurality of magnetic sub-droplets are split in a continuous and uniform manner. The magnetic droplet processing apparatus 10 includes a splitter 11 and a time-series magnetic field generator 12.
分裂器11包含一第一腔室111、一第二腔室113以及連通第一腔室111與第二腔室113的一流道112。第二腔室113連通流道112，且流道112介於第一腔室111與第二腔室113之間。流道112概略為一狹長通道，且流道112之截面A的面積範圍為0.25mm2 至1mm2 ，流道112之長度L的範圍為1mm至3mm。並且，本實施例之流道112之截面A的外形實質上可為一0.5mm x 0.5mm或是0.1mm x 0.1mm的矩形，但流道112之截面A的外形非用以限定本提案。舉例來說，在其他實施例中，流道112之截面A的外形也可以是圓形、橢圓形等。The splitter 11 includes a first chamber 111, a second chamber 113, and a first-class passage 112 that communicates the first chamber 111 and the second chamber 113. The second chamber 113 communicates with the flow channel 112, and the flow channel 112 is interposed between the first chamber 111 and the second chamber 113. The flow passage 112 is roughly an elongated passage, and the area of the section A of the flow passage 112 ranges from 0.25 mm 2 to 1 mm 2 , and the length L of the flow passage 112 ranges from 1 mm to 3 mm. Further, the outer shape of the cross section A of the flow path 112 of the present embodiment may be substantially a rectangle of 0.5 mm x 0.5 mm or 0.1 mm x 0.1 mm, but the outer shape of the cross section A of the flow path 112 is not intended to limit the present proposal. For example, in other embodiments, the profile of the cross section A of the flow channel 112 may also be circular, elliptical, or the like.
並且，本實施例之第一腔室111的體積尺寸以及第二腔室113的體積尺寸係遠大於流道112的體積尺寸。第一腔室111用以容置磁性母液滴，第二腔室113用以收集磁性子液滴。此外，流道112的內徑係小於磁性母液滴的外徑許多。Moreover, the volume size of the first chamber 111 and the volume size of the second chamber 113 of the present embodiment are much larger than the volume size of the flow passage 112. The first chamber 111 is for accommodating magnetic mother droplets, and the second chamber 113 is for collecting magnetic droplets. Further, the inner diameter of the flow path 112 is smaller than the outer diameter of the magnetic mother droplet.
更進一步來說，本實施例之分裂器11包含一本體114及一基板115。本體114具有一表面1144，表面1144向下凹陷而形成一第一凹槽1141、一第二凹槽1142以及介於第一凹槽1141及第二凹槽1142的一溝槽1143，溝槽1143連接第一凹槽1141及第二凹槽1142。並且，第一凹槽1141與第二凹槽1142具有一底面1145以及位於底面1145相對兩側的二側壁面1146，底面1145面向基板115，溝槽1143與底面1145及二側壁面1146保持一距離。上述於本體114上形成第一凹槽1141、第二凹槽1142及溝槽1143 的製作方式，可透過微影製程、3D列印、壓克力雕刻、雷射雕刻或是射出成形，但不以此為限。Furthermore, the splitter 11 of this embodiment includes a body 114 and a substrate 115. The body 114 has a surface 1144. The surface 1144 is recessed downward to form a first recess 1141, a second recess 1142, and a trench 1143 between the first recess 1141 and the second recess 1142. The trench 1143 The first groove 1141 and the second groove 1142 are connected. The first recess 1141 and the second recess 1142 have a bottom surface 1145 and two side wall surfaces 1146 on opposite sides of the bottom surface 1145. The bottom surface 1145 faces the substrate 115. The groove 1143 maintains a distance from the bottom surface 1145 and the two side wall surfaces 1146. . Forming a first recess 1141, a second recess 1142, and a trench 1143 on the body 114. The production method can be through lithography process, 3D printing, acrylic engraving, laser engraving or injection molding, but not limited to this.
基板115可以是但不侷限於塑膠基板或是玻璃基板，基板115貼合於本體114的表面1144而覆蓋住第一凹槽1141、第二凹槽1142及溝槽1143。如此，以令本體114的第一凹槽1141對應形成第一腔室111，本體114的第二凹槽1142對應形成第二腔室113，本體114的溝槽1143對應形成流道112。此外，本體114係位於基板115上，使得流道112的相對兩端係分別連接第一腔室111的底部及第二腔室113的底部。需注意的是，本實施例之流道112的相對兩端分別連接第一腔室111的底部及第二腔室113的底部之特徵非用以限定本提案。舉例來說，在其他實施例中，流道112的相對兩端也可適當地與第一腔室111的底部及第二腔室113的底部保持一距離而具有一段差。The substrate 115 can be, but not limited to, a plastic substrate or a glass substrate. The substrate 115 is attached to the surface 1144 of the body 114 to cover the first recess 1141, the second recess 1142, and the trench 1143. Thus, the first recess 1141 of the body 114 correspondingly forms the first chamber 111, and the second recess 1142 of the body 114 correspondingly forms the second chamber 113, and the groove 1143 of the body 114 correspondingly forms the flow channel 112. In addition, the body 114 is located on the substrate 115 such that opposite ends of the flow path 112 are connected to the bottom of the first chamber 111 and the bottom of the second chamber 113, respectively. It should be noted that the feature that the opposite ends of the flow channel 112 of the present embodiment are respectively connected to the bottom of the first chamber 111 and the bottom of the second chamber 113 is not intended to limit the proposal. For example, in other embodiments, the opposite ends of the flow channel 112 may also suitably maintain a distance from the bottom of the first chamber 111 and the bottom of the second chamber 113 for a period of time.
在本實施例中，時序性磁場產生器12係為一可產生時序性磁場的磁場產生裝置，而時序性磁場意指作用於某一固定位置的磁場(磁力線分佈)係隨著時間而改變。時序性磁場產生器12位於分裂器11具有基板115的一側。換句話說，分裂器11之基板115介於分裂器11之本體114與時序性磁場產生器12之間。時序性磁場產生器12包含多個磁性元件，且本實施例的這些磁性元件係為多個線圈123。每一線圈123可以是一印刷電路板線圈(print circuit board)、一電磁鐵線圈(electromagnet)或一微線圈(micro coil)，但不以此為限。這些線圈123係沿著流道112的延伸方向而依序排列，且這些線圈123面向基板115。進一步來說，分裂器 11之基板115介於分裂器11之本體114與這些線圈123之間。並且，這些線圈123於同一時間具有相異的磁極作用於分裂器11。In the present embodiment, the time-series magnetic field generator 12 is a magnetic field generating device that generates a time-series magnetic field, and the time-series magnetic field means that the magnetic field (magnetic field line distribution) acting at a certain fixed position changes with time. The time-series magnetic field generator 12 is located on the side of the splitter 11 having the substrate 115. In other words, the substrate 115 of the splitter 11 is interposed between the body 114 of the splitter 11 and the time-series magnetic field generator 12. The sequential magnetic field generator 12 includes a plurality of magnetic elements, and the magnetic elements of the present embodiment are a plurality of coils 123. Each of the coils 123 may be a printed circuit board, an electromagnet or a micro coil, but is not limited thereto. These coils 123 are sequentially arranged along the extending direction of the flow path 112, and these coils 123 face the substrate 115. Further, the splitter The substrate 115 of 11 is interposed between the body 114 of the splitter 11 and the coils 123. Further, these coils 123 have different magnetic poles acting on the splitter 11 at the same time.
此外，如第3圖所示，這些線圈123更區分為一第一線圈組121及一第二線圈組122。第一線圈組121位於第二線圈組122之之上，第一線圈組121介於分裂器11與第二線圈組122之間，且第一線圈組121的這些線圈123與第二線圈組122的這些線圈123係交錯設置。意即，第一線圈組121的其中一線圈123係位於第二線圈組122的相鄰兩線圈123之間的上方。更進一步來說，第一線圈組121的其中一線圈123投影至第二線圈組122時，第一線圈組121的此一線圈123之投影係分別重疊於第二線圈組122之相鄰兩線圈123之一的左半部L以及另一的右半部R。Further, as shown in FIG. 3, the coils 123 are further divided into a first coil group 121 and a second coil group 122. The first coil group 121 is located above the second coil group 122, the first coil group 121 is interposed between the splitter 11 and the second coil group 122, and the coils 123 and the second coil group 122 of the first coil group 121 These coils 123 are staggered. That is, one of the coils 123 of the first coil group 121 is located above the adjacent two coils 123 of the second coil group 122. Furthermore, when one of the coils 123 of the first coil group 121 is projected to the second coil group 122, the projection of the coil 123 of the first coil group 121 is overlapped with the adjacent two coils of the second coil group 122, respectively. The left half L of one of 123 and the right half R of the other.
請接著參照第4A圖至第4D圖並同時搭配第3圖，第4A圖至第4D圖係為根據第3圖之磁性液滴處理設備運作的示意圖。Please refer to FIG. 4A to FIG. 4D together with FIG. 3, and FIG. 4A to FIG. 4D are schematic diagrams showing the operation of the magnetic droplet processing apparatus according to FIG. 3.
於實際產出磁性子液滴21時，係先將第一腔室111、第二腔室113以及流道112充滿工作液30。工作液30係可包含礦物油(mineral oil)以及0.5%的介面活性劑(山梨糖醇酐油酸酯，span-80)，但不以此為限。接著將磁性母液滴20滴入第一腔室111，並且啟動時序性磁場產生器12。When the magnetic sub-drops 21 are actually produced, the first chamber 111, the second chamber 113, and the flow path 112 are first filled with the working fluid 30. The working fluid 30 may include mineral oil and 0.5% of an surfactant (sorbitan oleate, span-80), but is not limited thereto. The magnetic mother droplets 20 are then dropped into the first chamber 111 and the time-series magnetic field generator 12 is activated.
於第一時間點，時序性磁場產生器12的第一線圈組121的這些線圈123由左至右作用於分裂器11的磁極分別為N極、無磁性(X)、S極、N極，而時序性磁場產生器12的第二線圈組122的這些線圈123由左至右作用於分裂器11的磁極分別為S極、N極、無磁性(X)(如第4A圖所示)。如此，這些線圈123具有如第4A圖 所示的等效磁力分佈折線圖，且其中每一P1點所代表的是一正磁力(即吸力)，每一P2點所代表的是一負磁力(即斥力)。故此時，磁性母液滴20係被時序性磁場產生器12所產生的其中一正磁力所吸引而位於其中一P1點的正上方。At the first time point, the magnetic poles of the coils 123 of the first coil group 121 of the sequential magnetic field generator 12 acting from the left to the right on the splitter 11 are N poles, non-magnetic (X), S poles, and N poles, respectively. The magnetic poles of the coils 123 of the second coil group 122 of the time-series magnetic field generator 12 acting from the left to the right on the splitter 11 are respectively S pole, N pole, and non-magnetic (X) (as shown in FIG. 4A). As such, these coils 123 have a picture as shown in FIG. 4A. The equivalent magnetic force distribution line diagram shown, and each of the P1 points represents a positive magnetic force (ie, suction), and each P2 point represents a negative magnetic force (ie, repulsive force). Therefore, at this time, the magnetic mother droplet 20 is attracted by one of the positive magnetic forces generated by the sequential magnetic field generator 12 and located directly above one of the P1 points.
於第二時間點(即第一時間點的下一時間點)，時序性磁場產生器12的第一線圈組121的這些線圈123由左至右作用於分裂器11的磁極分別為無磁性(X)、S極、N極、無磁性(X)，而時序性磁場產生器12的第二線圈組122的這些線圈123由左至右作用於分裂器11的磁極分別為N極、無磁性(X)、S極(如第4B圖所示)。如此，這些線圈123具有如第4B圖所示的等效磁力分佈折線圖，且第二時間點之這些P1點與這些P2點的位置相對於第一時間點係朝右位移。如此，磁性母液滴20係受到這些線圈123之吸力及斥力位置改變後的牽引，而同樣朝右移動(即朝流道112方向位移)。At the second time point (ie, the next time point of the first time point), the magnetic poles of the coils 123 of the first coil group 121 of the sequential magnetic field generator 12 acting on the splitter 11 from left to right are respectively non-magnetic ( X), S pole, N pole, non-magnetic (X), and the coils 123 of the second coil group 122 of the time-series magnetic field generator 12 are N-pole and non-magnetic, respectively, acting on the magnetic poles of the splitter 11 from left to right. (X), S pole (as shown in Figure 4B). Thus, the coils 123 have an equivalent magnetic force distribution line graph as shown in FIG. 4B, and the positions of the P1 points and the P2 points at the second time point are shifted to the right with respect to the first time point. In this manner, the magnetic mother droplets 20 are pulled by the suction and repulsive positions of the coils 123, and are also moved to the right (i.e., displaced in the direction of the flow path 112).
於第三時間點(即第二時間點的下一時間點)，時序性磁場產生器12的第一線圈組121的這些線圈123由左至右作用於分裂器11的磁極分別為S極、N極、無磁性(X)、S極，而時序性磁場產生器12的第二線圈組122的這些線圈123由左至右作用於分裂器11的磁極分別為無磁性(X)、S極、N極(如第4C圖所示)。如此，這些線圈123具有如第4C圖所示的等效磁力分佈折線圖，且第二時間點之這些P1點與這些P2點的位置相對於第二時間點係朝右位移。如此，磁性母液滴20再度受到這些線圈123之吸力及斥力位置改變後的牽引，而再度朝右移動並朝流道112前進。此時，磁性母液滴20的部份體積被迫擠壓進入流道112，並由流道112連 接第二腔室113的一端分裂出磁性子液滴21(如第4D圖所示)。At the third time point (ie, the next time point of the second time point), the magnetic poles of the coils 123 of the first coil group 121 of the sequential magnetic field generator 12 acting on the splitter 11 from left to right are respectively S poles, N pole, non-magnetic (X), S pole, and the magnetic poles of the coil 123 of the second coil group 122 of the sequential magnetic field generator 12 acting from the left to the right on the splitter 11 are respectively non-magnetic (X), S pole , N pole (as shown in Figure 4C). Thus, the coils 123 have an equivalent magnetic force distribution line graph as shown in FIG. 4C, and the positions of the P1 points and the P2 points at the second time point are shifted to the right with respect to the second time point. In this manner, the magnetic mother droplets 20 are again pulled by the suction and repulsive positions of the coils 123, and are again moved to the right and proceed toward the flow path 112. At this time, a part of the volume of the magnetic mother droplet 20 is forced into the flow path 112 and is connected by the flow path 112. One end of the second chamber 113 splits the magnetic droplets 21 (as shown in Fig. 4D).
接著，重複循環如第4A圖至第4D圖所示之時序性磁場產生器12的運作，即可使磁性母液滴20能夠均勻、快速且連續不斷地分裂產出磁性子液滴21。並且，第二腔室113內的磁性子液滴21也一併受到時序性磁場產生器12的影響而不斷往右位移，以供後續的一檢測設備(未繪示)使用。Then, by repeating the operation of the sequential magnetic field generator 12 as shown in FIGS. 4A to 4D, the magnetic mother droplets 20 can be split, and the magnetic droplets 21 can be uniformly, rapidly and continuously divided. Moreover, the magnetic sub-droplets 21 in the second chamber 113 are also continuously displaced to the right by the sequential magnetic field generator 12 for use by a subsequent detecting device (not shown).
值得一提的是，本實施例之時序性磁場產生器12所產生的磁場係可同時對磁性母液滴20施以吸力及斥力，因此可加速磁性母液滴20或是磁性子液滴21的位移速度，甚至使磁性母液滴20或是磁性子液滴21以跳躍的方式快速位移。並且，藉由第一線圈組121的這些線圈123與第二線圈組122的這些線圈123交錯設置，且搭配這些線圈123具有無磁性(X)、S極、N極的三種狀態，使得時序性磁場產生器12所產生的等效磁力分佈於不同區段具有不同的梯度絕對值。舉例來說，如第4A圖所示，等效磁力分佈折線的區段S1(斜率較陡)的梯度絕對值係大於區段S2(斜率較平緩)的梯度絕對。如此一來，除了可準確控制磁性母液滴20或磁性子液滴21的位移方向外，也可彈性地調整磁性母液滴20或磁性子液滴21於每一區段的移動速率。It is to be noted that the magnetic field generated by the sequential magnetic field generator 12 of the present embodiment can simultaneously apply suction and repulsive force to the magnetic mother droplets 20, thereby accelerating the displacement of the magnetic mother droplets 20 or the magnetic droplets 21. The speed even causes the magnetic mother droplets 20 or the magnetic droplets 21 to be rapidly displaced in a jumping manner. Moreover, the coils 123 of the first coil group 121 and the coils 123 of the second coil group 122 are alternately arranged, and the coils 123 are provided with three states of no magnetic (X), S pole, and N pole, so that the timing is achieved. The equivalent magnetic force generated by the magnetic field generator 12 has different gradient absolute values in different sections. For example, as shown in FIG. 4A, the absolute value of the gradient of the segment S1 (slope of steepness) of the equivalent magnetic force distribution line is greater than the gradient absolute of the segment S2 (slighter slope). In this way, in addition to accurately controlling the direction of displacement of the magnetic mother droplets 20 or the magnetic droplets 21, the rate of movement of the magnetic mother droplets 20 or the magnetic droplets 21 in each segment can be elastically adjusted.
請接著參照第5圖，第5圖係為根據本提案另一實施例之磁性液滴處理設備的結構示意圖。Please refer to FIG. 5, which is a schematic structural view of a magnetic droplet processing apparatus according to another embodiment of the present proposal.
本實施例之磁性液滴處理設備10a包含一分裂器11a及一時序性磁場產生器12a。由於本實施例之分裂器11a的結構與第1圖之分裂器11的結構相同，因此便不再贅述。本實施例之磁性液滴 處理設備10a與第1圖之磁性液滴處理設備10a的差異在於時序性磁場產生器12a的結構。The magnetic droplet processing apparatus 10a of the present embodiment includes a splitter 11a and a time-series magnetic field generator 12a. Since the structure of the splitter 11a of the present embodiment is the same as that of the splitter 11 of Fig. 1, it will not be described again. Magnetic droplet of this embodiment The processing device 10a differs from the magnetic droplet processing device 10a of Fig. 1 in the structure of the time-series magnetic field generator 12a.
本實施例之時序性磁場產生器12a包含多個磁性元件以及一活動件124a，且本實施例的這些磁性元件係為多個永久磁鐵123a。這些永久磁鐵123a設置於活動件124a上，且位於分裂器11a下方的這些永久磁鐵123a係沿著流道112a的延伸方向而依序排列，且這些永久磁鐵123a面向分裂器11a的基板115a。並且，這些永久磁鐵123a具有相異的磁極作用於分裂器11a。就本實施例而言，這些永久磁鐵123a面向分裂器11a的磁極係為N極與S極交錯地排列。The sequential magnetic field generator 12a of the present embodiment includes a plurality of magnetic elements and a movable member 124a, and the magnetic elements of the present embodiment are a plurality of permanent magnets 123a. These permanent magnets 123a are disposed on the movable member 124a, and the permanent magnets 123a located under the splitter 11a are sequentially arranged along the extending direction of the flow path 112a, and these permanent magnets 123a face the substrate 115a of the splitter 11a. Further, these permanent magnets 123a have different magnetic poles acting on the splitter 11a. In the present embodiment, the magnetic poles of the permanent magnets 123a facing the splitter 11a are arranged such that the N poles and the S poles are alternately arranged.
此外，活動件124a係可相對分裂器11a平移，活動件124a可譬如但不限於一履帶。因此，當活動件124a相對分裂器11a而沿著流道112a的延伸方向來回平移時，這些永久磁鐵123a便依序通過分裂器11a的下方，以使分裂器11a所承受的磁場係隨著時間而改變，以使時序性磁場產生器12a所產生的磁場具有時序性的效果。其中，本實施例係以活動件124a相對分裂器11a來回平移為例，但不以此為限。舉例來說，在其他實施例中，活動件124a也可相對分裂器11a而持續朝同一方向平移。In addition, the movable member 124a is translatable relative to the splitter 11a, which may be, for example but not limited to, a crawler. Therefore, when the movable member 124a is translated back and forth along the extending direction of the flow path 112a with respect to the splitter 11a, the permanent magnets 123a sequentially pass under the splitter 11a so that the magnetic field of the splitter 11a is with time. The change is made so that the magnetic field generated by the sequential magnetic field generator 12a has a sequential effect. In this embodiment, the movable member 124a is translated back and forth with respect to the splitter 11a as an example, but is not limited thereto. For example, in other embodiments, the movable member 124a can also continue to translate in the same direction relative to the splitter 11a.
請接著參照第6圖，第6圖係為根據本提案另一實施例之磁性液滴處理設備的結構示意圖。Please refer to FIG. 6, which is a schematic structural view of a magnetic droplet processing apparatus according to another embodiment of the present proposal.
本實施例之磁性液滴處理設備10b包含一分裂器11b及一時序性磁場產生器12b。由於本實施例之分裂器11b的結構與第1圖之分裂器11的結構相同，因此便不再贅述。本實施例之磁性液 滴處理設備10b與第1圖之磁性液滴處理設備10b的差異在於時序性磁場產生器12b的結構。The magnetic droplet processing apparatus 10b of this embodiment includes a splitter 11b and a time-series magnetic field generator 12b. Since the structure of the splitter 11b of the present embodiment is the same as that of the splitter 11 of Fig. 1, it will not be described again. Magnetic fluid of this embodiment The difference between the droplet processing apparatus 10b and the magnetic droplet processing apparatus 10b of Fig. 1 lies in the structure of the time-series magnetic field generator 12b.
本實施例之時序性磁場產生器12b包含多個磁性元件以及一活動件124b，且本實施例的這些磁性元件係為多個永久磁鐵123b。這些永久磁鐵123b設置於活動件124b的周緣上，且位於分裂器11b下方的這些永久磁鐵123b係沿著流道112b的延伸方向而依序排列，且這些永久磁鐵123b面向分裂器11b的基板115b。並且，這些永久磁鐵123b具有相異的磁極作用於分裂器11b。就本實施例而言，這些永久磁鐵123b面向分裂器11b的磁極係N極與S極交錯地排列。The sequential magnetic field generator 12b of the present embodiment includes a plurality of magnetic elements and a movable member 124b, and the magnetic elements of the present embodiment are a plurality of permanent magnets 123b. The permanent magnets 123b are disposed on the periphery of the movable member 124b, and the permanent magnets 123b located below the splitter 11b are sequentially arranged along the extending direction of the flow path 112b, and the permanent magnets 123b face the substrate 115b of the splitter 11b. . Further, these permanent magnets 123b have different magnetic poles acting on the splitter 11b. In the present embodiment, the permanent magnets 123b face the magnetic poles of the splitter 11b, and the N poles are alternately arranged with the S poles.
此外，活動件124b係可相對分裂器11旋轉，活動件124b可譬如但不限於一轉盤。因此，當活動件124b相對分裂器11b旋轉時，這些永久磁鐵123b便依序通過分裂器11b的下方，以使分裂器11b所承受的磁場係隨著時間而改變，以使時序性磁場產生器12b所產生的磁場具有時序性的效果。其中，上述活動件124b相對分裂器11b的旋轉方式可以是來回旋轉或是持續同一轉向旋轉。In addition, the movable member 124b is rotatable relative to the splitter 11, and the movable member 124b can be, for example, but not limited to, a turntable. Therefore, when the movable member 124b rotates relative to the splitter 11b, the permanent magnets 123b sequentially pass under the splitter 11b, so that the magnetic field received by the splitter 11b changes with time, so that the time-series magnetic field generator The magnetic field generated by 12b has a sequential effect. The rotation of the movable member 124b relative to the splitter 11b may be a back-and-forth rotation or a continuous steering rotation.
根據上述實施例之磁性液滴處理設備，係藉由時序性磁場產生器產生時序性的磁場，以同時對磁性母液滴施以一吸力及一斥力而驅使磁性母液滴朝流道撞擊，以令磁性母液滴的部份體積擠壓進入流道後而分裂出磁性子液滴。如此，使磁性母液滴能夠均勻、快速且連續不斷地分裂產出磁性子液滴。According to the magnetic droplet processing apparatus of the above embodiment, the sequential magnetic field is generated by the sequential magnetic field generator to simultaneously apply a suction force and a repulsive force to the magnetic mother droplet to drive the magnetic mother droplet toward the flow path, so that A portion of the volume of the magnetic mother droplet is squeezed into the flow channel to split the magnetic droplet. In this way, the magnetic mother droplets can be split uniformly, rapidly and continuously to produce magnetic droplets.
雖然本提案以前述之較佳實施例揭露如上，然其並非用以限定本提案，任何熟習相像技藝者，在不脫離本提案之精神和範圍 內，當可作些許之更動與潤飾，因此本提案之專利保護範圍須視本說明書所附之申請專利範圍所界定者為準。While the present invention has been disclosed above in the foregoing preferred embodiments, it is not intended to limit the present proposal, and any skilled person skilled in the art will not depart from the spirit and scope of the present proposal. In the meantime, the scope of patent protection of this proposal shall be determined by the scope of the patent application attached to this specification.
10‧‧‧磁性液滴處理設備10‧‧‧Magnetic droplet processing equipment
10a‧‧‧磁性液滴處理設備10a‧‧‧Magnetic droplet processing equipment
10b‧‧‧磁性液滴處理設備10b‧‧‧Magnetic droplet processing equipment
11‧‧‧分裂器11‧‧‧ splitter
11a‧‧‧分裂器11a‧‧‧ splitter
11b‧‧‧分裂器11b‧‧‧ splitter
111‧‧‧第一腔室111‧‧‧First chamber
112‧‧‧流道112‧‧‧ flow path
112a‧‧‧流道112a‧‧‧ runner
112b‧‧‧流道112b‧‧‧ runner
113‧‧‧第二腔室113‧‧‧Second chamber
114‧‧‧本體114‧‧‧Ontology
1141‧‧‧第一凹槽1141‧‧‧first groove
1142‧‧‧第二凹槽1142‧‧‧second groove
1143‧‧‧溝槽1143‧‧‧ trench
1144‧‧‧表面1144‧‧‧ surface
1145‧‧‧底面1145‧‧‧ bottom
1146‧‧‧側壁面1146‧‧‧ side wall
115‧‧‧基板115‧‧‧Substrate
115a‧‧‧基板115a‧‧‧Substrate
115b‧‧‧基板115b‧‧‧Substrate
12‧‧‧時序性磁場產生器12‧‧‧Timed magnetic field generator
12a‧‧‧時序性磁場產生器12a‧‧‧Timed magnetic field generator
12b‧‧‧時序性磁場產生器12b‧‧‧Timed Magnetic Field Generator
121‧‧‧第一線圈組121‧‧‧First coil set
122‧‧‧第二線圈組122‧‧‧second coil set
123‧‧‧線圈123‧‧‧ coil
123a‧‧‧永久磁鐵123a‧‧‧ permanent magnet
123b‧‧‧永久磁鐵123b‧‧‧ permanent magnet
124a‧‧‧活動件124a‧‧‧Activities
124b‧‧‧活動件124b‧‧‧moving parts
20‧‧‧磁性母液滴20‧‧‧ Magnetic mother droplets
21‧‧‧磁性子液滴21‧‧‧Magnetic droplets
30‧‧‧工作液30‧‧‧Working fluid
第1圖係為根據本提案一實施例之磁性液滴處理設備的結構示意圖。Fig. 1 is a schematic structural view of a magnetic droplet processing apparatus according to an embodiment of the present proposal.
第2圖係為根據第1圖之分裂器的結構分解圖。Fig. 2 is an exploded view of the structure of the splitter according to Fig. 1.
第3圖係為根據第1圖之磁性液滴處理設備的側視圖。Fig. 3 is a side view of the magnetic droplet processing apparatus according to Fig. 1.
第4A圖至第4D圖係為根據第3圖之磁性液滴處理設備運作的示意圖。4A to 4D are schematic views showing the operation of the magnetic droplet processing apparatus according to Fig. 3.
第5圖係為根據本提案另一實施例之磁性液滴處理設備的結構示意圖。Figure 5 is a schematic view showing the structure of a magnetic droplet processing apparatus according to another embodiment of the present proposal.
第6圖係為根據本提案另一實施例之磁性液滴處理設備的結構示意圖。Figure 6 is a schematic view showing the structure of a magnetic droplet processing apparatus according to another embodiment of the present proposal.
10‧‧‧磁性液滴處理設備10‧‧‧Magnetic droplet processing equipment
11‧‧‧分裂器11‧‧‧ splitter
111‧‧‧第一腔室111‧‧‧First chamber
112‧‧‧流道112‧‧‧ flow path
113‧‧‧第二腔室113‧‧‧Second chamber
114‧‧‧本體114‧‧‧Ontology
115‧‧‧基板115‧‧‧Substrate
12‧‧‧時序性磁場產生器12‧‧‧Timed magnetic field generator
123‧‧‧線圈123‧‧‧ coil
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| TWI290481B (en) * | 2006-05-09 | 2007-12-01 | Univ Nat Yunlin Sci & Tech | Method for separating circular film-shaped magnetic droplet |
| EP1919618A2 (en) * | 2005-05-21 | 2008-05-14 | Core-Microsolutions, Inc. | Mitigation of biomolecular adsorption with hydrophilic polymer additives |
| WO2008091848A2 (en) * | 2007-01-22 | 2008-07-31 | Advanced Liquid Logic, Inc. | Surface assisted fluid loading and droplet dispensing |
| US20090014394A1 (en) * | 2005-10-22 | 2009-01-15 | Uichong Brandon Yi | Droplet extraction from a liquid column for on-chip microfluidics |
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| EP1919618A2 (en) * | 2005-05-21 | 2008-05-14 | Core-Microsolutions, Inc. | Mitigation of biomolecular adsorption with hydrophilic polymer additives |
| US20090014394A1 (en) * | 2005-10-22 | 2009-01-15 | Uichong Brandon Yi | Droplet extraction from a liquid column for on-chip microfluidics |
| TWI290481B (en) * | 2006-05-09 | 2007-12-01 | Univ Nat Yunlin Sci & Tech | Method for separating circular film-shaped magnetic droplet |
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