TWI483706B - A quantification of cardiac status enabled device - Google Patents

Description

Device with quantitative function of heart state

The invention relates to a medical auxiliary device, in particular to a device having a quantitative function of a heart state.

Chronic noncommudable diseases (NCDs) are important issues in public health and preventive medicine. With the pace of economic globalization and globalization, NCDs have become a national health burden, and the prevention and control of NCDs can be positively According to the United Nations estimates, there are currently 860 million people worldwide with chronic diseases, and 75-85% of medical expenses are related to chronic diseases, of which 40% of the elderly have chronic diseases, 10 years later. It will be doubled. It is estimated that by 2030, Taiwan’s elderly population over 65 will account for 21% of the total population. Large-scale clinical trials have demonstrated that prevention of myocardial infarction and death can be detected and treated early for high-risk population assessments, but these treatments are mostly an average assessment of the general risk, but not for individual treatments. Currently, personalized medicine or stratified medicine is effective for specific treatments of individuals and has low side effects in specific ethnic groups. The current model for cardiovascular disease for risk stratification and prediction is quite comparable. Numerous factors, such as the Framingham risk score (FRS, Framingham risk score) or the European PROCAM model, can be used as quantitative predictors of cardiovascular disease.

Cardiovascular disease ranks second among the top ten causes of death among Chinese people. From the perspective of three-stage and five-level preventive medicine, if a cardiovascular risk assessment and early warning mechanism can be established to remind people of the possibility of future cardiovascular disease, the public can be raised. Cognition of cardiovascular disease must have its effect on the prevention of related diseases; medicines for assessing cardiovascular risk at home and abroad There are many tools, metabolic syndrome risk factors are mainly for abdominal obesity, blood pressure, blood sugar, triglycerides and high-density cholesterol; Framingham Risk Score variables include gender, age, smoking, diabetes, systolic blood pressure, total cholesterol, High-density cholesterol, using these variables to predict the risk of death or cardiovascular events in the next decade; the Expert system is based on high blood pressure and clinical manifestations of proteinuria, cardiac hypertrophy, cerebral vascular deterioration, stroke and heart failure. Assessing cardiovascular risk factors, early warning has become the goal of current health policy efforts to reduce the risk of cardiovascular disease. Only the current assessment tools need to collect a variety of physiological parameters (such as the cholesterol index obtained through blood collection), which has a considerable degree of inconvenience and difficulty in the application of home-based independent health care required by the general public.

In terms of physiological mechanisms, the activity of the heart can be used to indicate the extent to which the body can respond immediately to external environmental changes. Through quantitative parameters of cardiac activity, it can be applied to long-term assessment of cardiac status, early warning of cardiovascular disease, and Home-based health care; in the study of quantitative prediction of cardiovascular disease, it is pointed out that heart rate variability can be used to assess changes in heart activity, wherein Heart Rate Variability (HRV) refers to heart rate interval Statistical analysis of the sequence, or the Fourier transform to calculate the distribution of energy between different frequency bands and the proportion change to understand the effects of sympathetic and parasympathetic nerves on cardiac activity; Time Irreversibility (TI) refers to the analysis of heart beats The degree of dispersion of the time series is quantified to quantify the activity parameters of the heart.

In the physiological structure and life cycle, through the regulation of the sympathetic/parasympathetic nervous system and hormones (adrenalin), the heart can adjust the rhythm to meet the physiological needs in the face of different external environmental conditions, and its characteristics are the heart. Dirty activity, pointed out in TI's research theory, the normal heart has greater elasticity, the complexity of the heartbeat interval time series is higher, and the two can be found compared with the time series after the time series inversion. The similarity between the two is low. With the emergence and severity of chronic cardiovascular disease, the complexity will decrease. The relative degree of similarity with the reversed time series is higher, that is, the response of the heart to external changes. The ability to reduce the risk of acute heart disease, by comparing and quantifying the similarity of the two time series, will be able to understand the characteristic state of the heart.

Therefore, how to propose a device having a quantitative function of the heart state for instantly understanding the characteristic state of the heart has become an important subject of those skilled in the art.

The present invention provides a cardiac state quantification device, a filter circuit for amplifying and filtering a potential difference signal recorded by an electrode disposed on a body surface of a living body to generate an electrocardiogram signal; a heart beat interval time series detection calculation module, Calculating an interval time of each heart beat according to the ECG signal generated by the filter circuit and outputting a corresponding heartbeat time sequence; and a complexity calculation module, performing the inversion calculation on the heartbeat time series to obtain a reverse A time series, and comparing the difference in complexity between the heartbeat time sequence and the inversion time series to generate an indicator parameter indicative of the activity state of the heart of the organism.

The apparatus for quantifying the state of the heart provided by the invention can obtain the quantified cardiac state parameters only by measuring the electrocardiogram signal of the human body, and can reduce the inconvenience of collecting various physiological parameters compared with the traditional clinical evaluation tools. An auxiliary device for information management of home autonomous heart state that is simple, fast and convenient to use.

Please refer to the first diagram and the second diagram at the same time. The first diagram is a schematic diagram of the apparatus 1 for quantifying the heart state of the present invention, and the second diagram is a functional block diagram of the apparatus for quantifying the heart state of the present invention. The cardiac state quantizing apparatus 1 of the first figure includes a signal input unit 11, an analog amplification/filtering circuit unit 12, a central processing unit 13, and a signal output unit 14. The specific operation mode is as shown in the second figure. The filter (Amplifier/Filter) circuit 21 can amplify and filter the potential difference signal recorded by the electrode 3 disposed on the body surface of the living body to generate the electrocardiogram signal 4. The central processing unit of the first figure may include a heart rate interval detection algorithm (RR Interval Detection) 22 and a complexity calculation module (Complexity Calculation) 23, wherein the heartbeat interval time series detection calculation module 22 Calculate the interval time 4 of each heart beat according to the ECG signal generated by the filter circuit 21 and output a corresponding heart beat time sequence, and the complexity calculation module 23 inverts the heart beat time series to obtain the inversion time. The sequence is compared and the difference in complexity of the heartbeat time sequence from the inversion time series is compared to generate an indicator parameter indicative of the activity state of the heart of the organism.

In a preferred aspect, the functions of the heartbeat interval time series detection calculation module and the complexity calculation module can be implemented algorithmically by software or carcass. For example, the software can perform a RR Interval Detection algorithm and a Complexity Calculation algorithm, and the central processing unit executes the algorithms.

The third figure is a functional block diagram of the complexity calculation algorithm of the present invention. First, the heartbeat interval time sequence of one of the fixed data lengths is detected/inverted, and the two time series are reconstructed by phase space (Phase). The Space Reconstruction (PSR) method establishes the corresponding phase space matrix (PSR Matrix #1, respectively). PSR Matrix #2) is used to indicate the complexity of the time series. Finally, after the matrix repeating region is removed by the mutual exclusion or (XOR) operation of the matrix, the remaining non-repetitive regions can be used to compare and quantize the two. The similarity of time series.

The fourth figure is the normal heartbeat interval time series of the present invention and its complexity phase matrix, and the fifth figure shows the reverse sequence and its complexity phase matrix, which can be found to be complicated in the heartbeat interval time series in normal cases. The degree is higher and the similarity between the two time series is lower.

The sixth figure is the heartbeat interval time series and its complexity phase matrix recorded by the patient with chronic cardiovascular disease of the present invention, and the seventh figure shows the reverse sequence and its complexity phase matrix, which can be found in the abnormal case, The complexity of the heartbeat interval time series is low and the similarity between the two time series is high.

The eighth figure is the statistical result of the individual quantitative index parameters of the normal and abnormal signals collected by the present invention, the abscissa is the receipt number, and the ordinate is the quantitative index parameter, and the quantitative parameter value of the normal case can be found to be high (representing similarity) The degree is lower, both above the value of 60), while the value of the quantitative indicator parameter of the abnormal case is lower (indicating that the similarity is higher, all below the value 60).

The ninth figure is the statistical analysis result of the quantitative index parameters of the normal and abnormal signals collected by the present invention, and the average value of the quantitative index parameters of the normal case is 66.8, the standard deviation is 5.67, and the mean value of the quantitative index parameter of the abnormal case is obtained. At 46.5, the standard deviation is 9.8, and there is a significant statistical difference between the two, so the index quantified by the present invention can be applied to the auxiliary reference of the heart state.

In summary, the heart state quantification device of the present invention first finds the heartbeat time sequence of the human heart, and then inverts the heartbeat time sequence to obtain a reverse time series, and compares the heartbeat time sequence with the Reverse the complexity of the time series The difference is to generate an indicator parameter indicative of the active state of the heart of the organism. In this way, the indicator parameters can provide general users and medical staff as an auxiliary reference for early warning of cardiovascular related diseases.

The above-described embodiments are merely illustrative of the principles, features, and effects of the present invention, and are not intended to limit the scope of the present invention. Any person skilled in the art can recite the above without departing from the spirit and scope of the present invention. The embodiment is modified and changed. Any equivalent changes and modifications made by the disclosure of the present invention should still be covered by the following claims. Therefore, the scope of protection of the present invention should be as set forth in the scope of the claims described below.

1, 2‧‧‧ Quantitative device for cardiac status

11‧‧‧ Input unit

12‧‧‧ analog amplification/filtering circuit unit

13‧‧‧Central Processing Unit

14‧‧‧Signal output unit

21‧‧‧Filter circuit

22‧‧‧ Heartbeat Interval Time Series Detection and Calculation Module

23‧‧‧Complexity Calculation Module

3‧‧‧Electrode

4‧‧‧ ECG signal

5‧‧‧ Heartbeat interval time series

The first figure is a schematic illustration of a quantification device for the heart state of the present invention.

The second figure is a functional block diagram of the quantification device of the heart state of the present invention.

The third figure is a functional block diagram of the complexity calculation algorithm of the present invention.

The fourth figure is the normal heartbeat interval time series of the present invention and its complexity phase matrix.

The fifth figure is the inverse time series of the normal heartbeat interval time series and its complexity phase matrix according to the present invention.

The sixth figure is the abnormal heartbeat interval time series and its complexity phase matrix according to the present invention.

The seventh figure is the inverse time series of the abnormal heartbeat interval time series and the complexity phase matrix thereof according to the present invention.

The eighth graph is a statistical result of the individual quantitative index parameters of the normal and abnormal signals collected by the quantification device of the cardiac state of the present invention.

The ninth graph is a statistical analysis result of the quantified index parameters of the normal and abnormal signals collected by the quantification device of the cardiac state of the present invention.

2‧‧‧Quantity device for cardiac status

21‧‧‧Filter circuit

22‧‧‧ Heartbeat Interval Time Series Detection and Calculation Module

23‧‧‧Complexity Calculation Module

3‧‧‧Electrode

4‧‧‧ ECG signal

5‧‧‧ Heartbeat interval time series

Claims (4)

A device for quantifying a cardiac state, comprising: a filter circuit for amplifying and filtering a potential difference signal recorded by an electrode disposed on a body surface of a living body to generate an electrocardiogram signal; and a heartbeat interval time series detection calculation module Calculating an interval time of each heartbeat according to the ECG signal generated by the filter circuit and outputting a corresponding heartbeat time sequence; and a complexity calculation module, inverting the heartbeat time sequence to obtain a reverse time series And comparing the difference between the heartbeat time sequence and the complexity of the inversion time series to generate an indicator parameter indicative of the activity state of the heart of the organism. The apparatus for quantifying cardiac status according to claim 1, wherein the complexity calculation module inverts a time interval interval of a fixed data length to obtain the reverse time sequence, and then The heartbeat interval time series and the inversion time series respectively establish a corresponding phase space matrix by phase space reconstruction to indicate the complexity of the heartbeat interval time series and the inversion time series. The apparatus for quantizing a cardiac state according to claim 2, wherein the complexity calculation module transmits the heartbeat interval time series and the phase space of the inversion time series through mutual exclusion or operation of the matrix. After the repeated regions of the matrix are removed, the remaining non-repetitive regions are compared and quantified. The apparatus for quantifying a heart state according to claim 1, wherein the heartbeat interval time series detection calculation module and the complexity calculation module are implemented by using a software or a firmware.