TWI482636B - Desensitizing toothpaste - Google Patents

Description

Anti-sensitive toothpaste

The invention relates to an anti-sensitive toothpaste, in particular to an anti-sensitive toothpaste to which DP biomedical glass is added.

Tooth sensitivity is one of the common dental symptoms, with a prevalence of approximately 8% to 35%. Patients with sensitive symptoms often cannot find immediate and lasting treatments, so tooth sensitivity has become an important topic in dental clinics.

Fig. 1 is a perspective view showing a tooth profile and a partial surface enlarged view thereof. As shown in Fig. 1, the teeth can be divided into enamel 10, dentin 20 and pulp 30 from the outside to the inside. Among them, the dentin 20 is mainly composed of hydroxyapatite, and has a plurality of dentinal tubules 21 connecting the enamel 10 and the pulp chamber 30, and the pulp chamber 30 is filled with nerves 31, blood vessels and lymphatic vessels.

A common cause of tooth sensitivity is the exposure or densification of the enamel 10 causing the exposure of the dentin 20, causing the liquid in the dentinal tubule 21 to be easily affected by the cold, heat, acid, and alkali in the oral cavity to flow inward or outward. The flow will indirectly activate the nerve 31 and create a feeling of pain. Therefore, patients with sensitive symptoms of teeth It is easy to feel pain by activation of the nerves 31 in the pulp chamber 30 by drinking ice water or eating.

There are several common methods for treating tooth sensitivity. First, the protein precipitation method: the protein in the dentin tubules protein precipitation to reduce the flow of liquid, thereby reducing the chance of activation of the nerve, however, this method can not maintain long-term efficacy. Second, inhibition of nerve activation: the use of potassium ions to block nerve conduction of nerves to reduce pain, however, this method can only be soothed, can not achieve the effect of prevention. Third, the dentinal tubule occlusion method: the use of chemical substances to block the dentinal tubules to reduce the diameter of the dentinal tubules, thereby effectively sealing the dentinal tubules and blocking external stimuli. In the above method, if it can be combined with simple and convenient application, such as brushing, gargle, smearing, etc., it can effectively alleviate the symptoms of sensitive teeth. Among them, the application of toothpaste is the easiest and most economical.

Figure 2 is a scanning electron micrograph of a dentin test piece after using a conventional anti-sensitive toothpaste. As shown in Fig. 2, after using the anti-sensitive toothpaste based on the dentinal tubule occlusion method on the market, the crystalline substance is not deposited in the dentinal tubule, and the opening of the dentinal tubule is still not effectively blocked, resulting in Symptoms of tooth sensitivity still exist. Therefore, there is a need for an anti-sensitive toothpaste that can form deposits in dentinal tubules and block dentinal tubules.

The present invention is an anti-sensitive toothpaste comprising: DP biomedical glass; a thickener; a moisturizer; and a surfactant. Among them, DP biomedical glass contains 8.4% Na ₂ O, 40.6% CaO, 39% SiO ₂ and 12% P ₂ O ₅ based on the total weight of DP biomedical glass. The invention aims to achieve the long-term slowing of tooth sensitivity by means of occluding dentinal tubules.

The present invention provides an anti-sensitive toothpaste comprising: DP biomedical glass containing 8.4% Na ₂ O, 40.6% CaO, 39% SiO ₂ and 12% P based on the total weight of DP biomedical glass. ₂ O ₅ , DP biomedical glass accounts for between 5% and 40% of the total weight of the anti-sensitive toothpaste; thickener, which accounts for between 1% and 5% of the total weight of the anti-sensitive toothpaste; humectant, It is between 25% and 35% of the total weight of the anti-sensitive toothpaste; and the surfactant, which is between 1% and 5%, based on the total weight of the anti-sensitive toothpaste.

By the implementation of the present invention, at least the following advancements can be achieved: first, the dentinal tubules can be easily and effectively blocked; and second, the symptoms of tooth sensitivity can be slowed down for a long period of time.

In order to make those skilled in the art understand the technical content of the present invention and implement it, and according to the disclosure, the patent scope and the drawings, the related objects and advantages of the present invention can be easily understood by those skilled in the art. The detailed features and advantages of the present invention will be described in detail in the embodiments.

10‧‧‧Enamel

20‧‧‧dentine

21‧‧‧ dentinal tubules

30‧‧‧ pulp cavity

31‧‧‧ nerve

1 is a perspective view of a tooth profile and a partial surface enlargement thereof; FIG. 2 is a scanning electron micrograph of a dentin test piece after using a conventional anti-sensitive toothpaste; FIG. 3 is an embodiment of the present invention. An X-ray diffraction analysis chart of a DP medical glass; FIG. 4 is a scanning electron micrograph of a DP medical glass according to an embodiment of the present invention; 5A is a scanning electron micrograph of a surface of a dentin test piece before use of an anti-sensitive toothpaste according to an embodiment of the present invention; FIG. 5B is a cross-sectional view of a dentin test piece according to an embodiment of the present invention. Scanning electron micrograph before toothpaste; FIG. 6A is a scanning electron micrograph of the surface of a dentin test piece after using anti-sensitive toothpaste according to an embodiment of the present invention; FIG. 6B is a view of an embodiment of the present invention Scanning electron micrograph 1 of the dentin test piece after using the anti-sensitive toothpaste; FIG. 6C is a scanning electron micrograph of the cross section of the dentin test piece after using the anti-sensitive toothpaste according to the embodiment of the present invention 2; and FIG. 6D is a scanning electron micrograph 3 of a cross section of a dentin test piece according to an embodiment of the present invention after using an anti-sensitive toothpaste.

An embodiment of the present invention is an anti-sensitive toothpaste comprising: DP biomedical glass; a thickener; a moisturizer; and a surfactant.

DP biomedical glass containing 8.4% Na ₂ O, 40.6% CaO, 39% SiO ₂ and 12% P ₂ O ₅ based on the total weight of DP biomedical glass. DP biomedical glass has good biocompatibility and has been used as a material for bone filling in the past to form a stable bond with the bone surface. At the same time, since DP biomedical glass has a high calcium and phosphorus composition and a low SiO ₂ composition, it has a high solvency and can release more calcium and phosphorus ions instantaneously upon dissolution. When used for the preparation of anti-sensitive toothpaste, the dissolution can be completed instantaneously by short brushing action, and the calcium and phosphorus concentrations in the oral cavity are instantaneously increased, and the calcium and phosphorus ion product is higher than the solubility basis constant (ksp). At the time, the calcium and phosphorus ions deep into the dentinal tubules after dissolution will precipitate to form the crystal of the hydroxyapatite, thereby blocking the diameter of the dentinal tubules, so as to achieve the long-term effect of slowing the sensitivity of the teeth.

DP biomedical glass is prepared as follows: the raw materials Na ₂ O, CaO, SiO ₂ and P ₂ O ₅ are mixed according to the weight ratios of 8.4%, 40.6%, 39% and 12%, respectively, and placed in a ball mill jar, and placed in Ten alumina balls each having a diameter of 1 cm, 0.5 cm, and 0.3 cm were used as a mixed medium, and 100 ml of ethanol was added for wet grinding. After 8 hours of ball milling, the aluminum balls were taken out, and the raw materials were placed in an oven at 80 ° C to evaporate the ethanol to obtain uniformly mixed batch materials. Pour the raw meal powder into a white gold crucible and heat it in a high temperature furnace at 1410 ° C for 1.5 hours to form a glass. After the glass is melted, it is quickly taken out from the high temperature furnace and quickly poured into a stainless steel pan filled with water for quenching. The glass which was quenched by quenching was placed in an oven at 80 ° C to dry the water, and the dried glass was ground into a powder by a grinder, and the powder particles were sieved by a 400 mesh screen to complete the preparation of DP biomedical glass powder.

As shown in Fig. 3, the prepared DP biomedical glass was subjected to diffraction angle detection by a Regaku X-ray powder diffractometer (Japan). The crystal phase analysis was carried out under the operating conditions of a voltage of 30 kV, a current of 20 mA, a scanning speed of 4°/min, and a scanning angle of 2θ=10 to 60° using a CuKa (1.5432 Å) X-ray source and a Ni filter. The diffraction peak is compared with the standard map of JCPDS by a computer automatic matching system to identify the crystal phase and crystallinity of the sample to be tested.

As shown in Fig. 4, the prepared DP biomedical glass was observed with a Hitachi-S4700 field emission scanning electron microscope at a high magnification (10000X) to observe the particle shape and size of DP biomedical glass powder, and to use image 撷Acquisition and processing system (analySiS 3.0, Soft Imaging System GmbH, Germany) records DP The particle form of the biomedical glass powder, wherein the DP biomedical glass powder may have a particle size of 3 microns.

The DP biomedical glass is between 5% and 40%, preferably between 15% and 30%, more preferably between 15% and 25%, based on the total weight of the anti-sensitive toothpaste. In addition to being used as an anti-sensitive toothpaste for blocking dentinal tubules, DP Biomedical Glass is also used as an abrasive in anti-sensitive toothpaste. The abrasive is used to remove plaque, tartar and food residue, so the abrasive should have a certain hardness, so that the grinding effect can be enough to achieve the cleaning effect, but it will not damage the tooth surface and periodontal tissue. Further, the anti-sensitive toothpaste may further include calcium phosphate as an abrasive, which is between 5% and 25% by weight based on the total weight of the anti-sensitive toothpaste. The anti-sensitive toothpaste may further comprise zinc oxide as an abrasive, which is between 1% and 10% by weight based on the total weight of the anti-sensitive toothpaste.

The function of the thickener is to keep the solid and liquid components of the anti-sensitive toothpaste uniform by diffusing, expanding and absorbing water to avoid evaporation of water. The thickener affects the viscosity of the anti-sensitive toothpaste. In order to maintain the proper viscosity of the anti-sensitive toothpaste, the thickener accounts for between 1% and 5%, preferably between 1% and 3%, of the total weight of the anti-sensitive toothpaste. More preferably, it may be 1.5% by weight based on the total weight of the anti-sensitive toothpaste, wherein the thickener may be sodium carboxymethylcellulose.

The role of humectants is to maintain the wettability of sensitive toothpastes and to protect gums and tooth tissues. The humectant in the anti-sensitive toothpaste is between 25% and 35% by weight of the total anti-sensitive toothpaste, more preferably 30% by weight of the total anti-sensitive toothpaste, wherein the humectant may be glycerin.

The surfactant contains a hydrophilic group and a lipophilic group to uniformly mix the components of the anti-sensitive toothpaste. The surfactant in the anti-sensitive toothpaste accounts for between 1% and 5%, preferably between 1% and 3%, based on the total weight of the anti-sensitive toothpaste. Preferably, it may comprise 1.5% by weight of the total anti-allergic toothpaste, wherein the surfactant may be sodium lauryl sulfate.

The anti-sensitive toothpaste may further comprise potassium nitrate, which is between 1% and 5%, based on the total weight of the anti-sensitive toothpaste. When potassium nitrate is dissolved in the oral environment, potassium ions are released. When the concentration of extracellular potassium ions increases, the sodium ion channel will open, causing extracellular sodium ions to flow into the cells, causing the membrane potential to rise and depolarization. The action potential is induced, which in turn causes the potassium ion channel to open. Since the extracellular potassium ions are maintained at a high concentration state, the potassium ions in the cells cannot flow outward, so the membrane potential cannot be recovered, and the cell membrane cannot be repolarized. In this state, even if the cells are stimulated, the action potential cannot be generated, so that the effect of blocking nerve conduction is achieved, and the symptoms sensitive to the teeth can be relieved in a short period of time.

Since potassium nitrate can provide a short-acting anti-allergic effect, DP biomedical glass can effectively seal dentinal tubules through dissolution and recrystallization to achieve long-acting anti-allergy effects. Therefore, after adding potassium nitrate, the anti-sensitive toothpaste can simultaneously achieve short-acting and long-acting anti-allergy effects.

The anti-sensitive toothpaste may further comprise sodium dihydrogen phosphate, which is between 0.001% and 2% by weight based on the total weight of the anti-sensitive toothpaste. Sodium dihydrogen phosphate can provide phosphate ions in the oral environment, thus increasing the concentration of phosphorus ions and increasing the chance of calcium phosphate precipitation to form crystals of hydroxyapatite. At the same time, it is also possible to adjust the pH value of the anti-sensitive toothpaste to the desired range.

The anti-sensitive toothpaste may further comprise phosphoric acid, which is between 0.001% and 2% by weight based on the total weight of the anti-sensitive toothpaste. Phosphoric acid provides a biased environment, accelerates the dissolution of DP biomedical glass, and provides phosphate ions, which increases the concentration of phosphorus ions and increases the chance of calcium phosphate precipitation to form crystals of hydroxyl apatite. At the same time, you can Adjust the pH of the anti-sensitive toothpaste to the desired range.

The anti-sensitive toothpaste may further include a fluorine compound. In the brushing process, anti-sensitive toothpaste including fluoride can release fluoride ions in the oral cavity, which can improve the remineralization of teeth and reduce the demineralization ability. In the Republic of China, the fluoride ion concentration in toothpaste should be lower than 1450ppm. The fluoride is between 0.1% and 0.2% by weight based on the total weight of the anti-sensitive toothpaste, and more preferably about 0.15% by weight based on the total weight of the anti-sensitive toothpaste. Among them, the fluorine compound may be sodium fluoride.

The anti-sensitive toothpaste may further comprise a flavoring agent. The flavoring agent can provide a variety of odors when brushing teeth, so that the breath is fresh or the mouthfeel when brushing is improved. The flavoring agent is between 0.1% and 0.2% by weight of the total anti-sensitive toothpaste, wherein the flavoring agent may be mint and may be 0.15% by weight based on the total weight of the anti-sensitive toothpaste.

The anti-sensitive toothpaste may further comprise water, which is between 10% and 25% by weight based on the total weight of the anti-sensitive toothpaste, to dissolve or mix all of the above ingredients.

A first exemplary embodiment of an anti-sensitive toothpaste is detailed as follows: 16% calcium phosphate powder, 5% zinc oxide powder, 20% DP biomedical glass powder, 1% phosphoric acid, based on the total weight of the anti-sensitive toothpaste Sodium dihydrogen powder, 1.5% sodium carboxymethylcellulose powder, 1.5% sodium lauryl sulfate powder and 0.15% sodium fluoride powder, and the above powder was mixed. Next, 30% glycerin, 1% phosphoric acid, 0.15% mint, and 23.7% water were supplied, and the above liquid materials were mixed. Finally, the mixed powder and the mixed liquid substance are stirred until uniform in a large beaker to obtain an anti-sensitive toothpaste.

A second exemplary embodiment of the anti-sensitive toothpaste is detailed as follows: 17% calcium phosphate powder, 5% zinc oxide powder, 20% DP biomedical glass powder, 1.5% carboxy by total weight of the anti-sensitive toothpaste Methylcellulose sodium powder, 1.5% of twelve A sodium alkyl sulfate powder and 0.15% sodium fluoride powder were mixed with the above powder. Next, 30% glycerin, 2% potassium nitrate, 0.15% mint, and 22.7% water were supplied, and the above liquid materials were mixed. Finally, the mixed powder and the mixed liquid substance are stirred until uniform in a large beaker to obtain an anti-sensitive toothpaste.

A third exemplary embodiment of the anti-sensitive toothpaste is detailed as follows: 17% calcium phosphate powder, 5% zinc oxide powder, 20% DP biomedical glass powder, 1.5% carboxy by total weight of the anti-sensitive toothpaste Methylcellulose sodium powder, 1.5% sodium lauryl sulfate powder and 0.15% sodium fluoride powder, and the above powder was mixed. Next, 30% glycerin, 1% phosphoric acid, 0.15% mint, and 23.7% water were supplied, and the above liquid materials were mixed. Finally, the mixed powder and the mixed liquid substance are stirred until uniform in a large beaker to obtain an anti-sensitive toothpaste.

A fourth exemplary embodiment of the anti-sensitive toothpaste is detailed as follows: 17% calcium phosphate powder, 5% zinc oxide powder, 20% DP biomedical glass powder, 1.5% carboxy by total weight of the anti-sensitive toothpaste Methylcellulose sodium powder, 1.5% sodium lauryl sulfate powder and 0.15% sodium fluoride powder, and the above powder was mixed. Next, 30% glycerin, 0.15% mint, and 24.7% water were supplied, and the above liquid materials were mixed. Finally, the mixed powder and the mixed liquid substance are stirred until uniform in a large beaker to obtain an anti-sensitive toothpaste.

A fifth exemplary embodiment of the anti-sensitive toothpaste is detailed as follows: 16% calcium phosphate powder, 5% zinc oxide powder, 20% DP biomedical glass powder, 1% phosphoric acid, based on the total weight of the anti-sensitive toothpaste Sodium dihydrogen powder, 1.5% sodium carboxymethylcellulose powder, 1.5% sodium lauryl sulfate powder and 0.15% sodium fluoride powder, and the above powder was mixed. Next, 30% glycerin, 1% phosphoric acid, 0.15% mint, 2% potassium nitrate, and 21.7% water were supplied, and the above liquid materials were mixed. Finally, the mixed powder and the mixed liquid substance are stirred until uniform in a large beaker to obtain an anti-sensitive toothpaste.

In order to prove that the above-mentioned anti-sensitive toothpaste has the effect of filling the dentinal tubules, thereby improving the symptoms of the user's teeth. First, collect several newly removed human large molars with complete crowns and no fillings. Ultrasonic washing machines (Sonicflex 2000, Kavo Co., Biberbach, Germany) remove the calculus and teeth on the surface. Weekly organization. Next, using a slow saw blade (Isomet low speed saw, Buehler LTD., MA, USA) diamond saw blade (Buehler watering blade, 10.2 cm x 0.3 mm, arbor size 1/2 inch, series 15 LC diamond, Buehler LTD. , MA, USA) The occlusal surface enamel of all teeth was removed in the horizontal direction, and then the distance between the teeth and the neck was measured by 2 mm. The diamond saw blade was cut in parallel to obtain a dentin test piece as an experimental sample. All dentin test pieces were immersed in 17% EDTA solution and shaken in an ultrasonic oscillator for two minutes to remove impurities. After taking out, rinse with a large amount of distilled water, and place the dentin test pieces in an oven to dry.

As shown in Fig. 5A and Fig. 5B, the dentinal tubule opening and the dentinal tubule cross section on the surface of the dentin test piece were observed by an electron microscope (Topcon ABT-60, Japan). It can be seen that the opening of the dentinal tubule is free of deposition of crystalline material, and no crystal material deposition is observed in the case of sealing the dentinal tubule. The opening diameter of the dentinal tubules is approximately 3.0 microns to 4.0 microns.

Next, the dentin test piece is brushed with the artificial saliva for 10 minutes in the anti-sensitive toothpaste of the embodiment of the present invention, and the surface particles are washed away with water after the dentin test piece is brushed. After the dentin test piece is dried, the dentin test piece is removed by ultrasonic cleaning machine (Sonicflex 2000, Kavo Co., Biberbach, Germany), and dehydrated by alcohol concentration, soaked in 50% in sequence. , 70%, 80%, 90 %, 95% of the alcohol in each fifteen minutes, then soaked twice with 100% alcohol for 15 minutes each. The dried specimen was adhered to the stage with a carbon ribbon, and coated with a gold coating machine (sputter coater, BIO-RED SC 502, Fisons plc Registered Office, England) using an electron microscope (Topcon ABT-60, Japan) Observe the presence of crystalline material on the surface of the test piece and the closure of the opening of the dentinal tubule.

As shown in FIGS. 6A to 6D, FIG. 6A is an electron microscopic image of the dentinal tubule opening on the surface of the dentin test piece observed by an electron microscope after using the anti-sensitive toothpaste of the embodiment of the present invention, and FIG. 6B Figure 6D is an electron microscopic image of the dentinal tubule profile. In the electron microscopic image, crystal material deposition can be seen in the vicinity of the opening of the dentinal tubule and in the dentinal tubule, and the deposition of the crystalline material closes part of the dentinal tubule, so that the opening of the dentinal tubule becomes smaller, thereby enabling The symptoms of sensitive teeth in the user are improved. The sensitive toothpaste of the embodiment of the invention can improve the symptoms of tooth sensitivity for a long time, and can also add potassium nitrate to provide short-acting soothing, and achieve the effect of long-term and short-term treatment.

The embodiments are described to illustrate the features of the present invention, and the purpose of the present invention is to enable those skilled in the art to understand the present invention and to implement the present invention without limiting the scope of the present invention. Equivalent modifications or modifications made by the spirit of the disclosure should still be included in the scope of the claims described below.

Claims (5)

An anti-sensitive toothpaste comprising: DP biomedical glass comprising 8.4% Na ₂ O, 40.6% CaO, 39% SiO ₂ and 12% P ₂ O ₅ based on the total weight of the DP biomedical glass. The DP biomedical glass accounts for between 5% and 40% of the total weight of the anti-sensitive toothpaste; the thickener accounts for between 1% and 5% of the total weight of the anti-sensitive toothpaste; a humectant, It accounts for between 25% and 35% of the total weight of the anti-sensitive toothpaste; the surfactant, which is between 1% and 5% by weight of the total anti-sensitive toothpaste; and phosphoric acid, which accounts for the anti-sensitive The total weight of the toothpaste is between 0.001% and 2%. The anti-sensitive toothpaste of claim 1, further comprising potassium nitrate, which is between 1% and 5% by total weight of the anti-sensitive toothpaste. The anti-sensitive toothpaste of claim 1, further comprising sodium dihydrogen phosphate, which is between 0.001% and 2% by weight based on the total weight of the anti-sensitive toothpaste. The anti-sensitive toothpaste of claim 1, further comprising a fluorine compound, which is between 0.1% and 0.2% by weight based on the total weight of the anti-sensitive toothpaste. The anti-allergic toothpaste according to claim 1, which further comprises a flavoring agent, which is between 0.1% and 0.2% by weight based on the total weight of the anti-sensitive toothpaste.