TWI472737B - Gel dosimeter automated manufacturing and loading equipment for the preparation and filling of the gel dosimeter steps - Google Patents

Description

Gel Dosimeter Automated Manufacturing and Filling Equipment Manufacturing and Filling Gel Dosimeter Steps

The present invention relates to the preparation of radiation dose verification tools and, more particularly, to automated manufacturing, filling equipment and systems for gel dosimeters.

High-tech radiation therapy is known to be one of the main methods for treating cancer, and it has greatly contributed to the control of cancer lesions and cure rates. In traditional radiotherapy, it is often faced with the problem that it is impossible to completely limit the radiation to the tumor. When the tumor cells are killed by radiation, the normal tissue around the tumor is inevitably subject to some radiation dose damage. When high, the radiation dose of normal tissues also increases. Clinical treatment sometimes reduces the dose of radiation administered to the tumor in order to prevent normal tissues and vital organs from being exposed to too much radiation dose, so that the tumor cells may not be able to obtain a sufficient lethal dose, thereby affecting the overall radiation treatment effect.

At present, computerized tomography has been developed to present the anatomical positional relationship between the tumor and the surrounding normal tissue in a three-dimensional image. The incidence of the radiation beam can be changed according to the growth shape of the tumor. In other words, it is a pair of tumors. Conformal radiation therapy for degree space. Intensity Modulated Radiation Therapy (IMRT) is an extension of three-dimensional spatial conformal therapy. Using computerized tomography to reconstruct the stereoscopic image of the three-dimensional space of the tumor, and using Beam's Eye View to determine the multiple fields of the three-dimensional space, so that the doctor can make a treatment for the stereoscopic image of the patient's tumor and surrounding normal tissues. plan. IMRT can moderately adjust the percentage of radiation dose in tumors and normal tissues, increase the radiation dose at the tumor site, reduce the radiation dose of normal tissues, increase the tumor control rate and reduce the risk of normal tissue or organ damage.

The completion of the IMRT overall project involves many illuminations of the field and the giving of different strengths. Therefore, in addition to accurately depicting the extent of the lesion before treatment, whether the dose and position calculated in the treatment site and the treatment plan are different, and whether each point in the tumor receives the correct dose is very An important part. In other words, the IMRT must function under the premise of accurate positioning to avoid the loss of millimeters, and the results of the dose distribution are thousands of miles away. Therefore, the ideal dosimeter can complete the dose verification and recording to ensure the quality of treatment and to play the role of intensity regulation of radiation therapy.

Currently, the radiation dose verification tools commonly used in clinical practice include free cavity, thermal luminometer, negative film and polymer gel dosimeter, wherein the polymer gel dosimeter has better dose measurement capability and higher resolution. For the current three-dimensional space and the increasingly complex radiation therapy, it is of great help.

The formulation of the composition of the gel dosimeter, as stated in the master's thesis "Research on Polymer Gel Dosimeter - Optimization of n-NIPAM gel Formula" by Dr. Xie Baijun, Institute of Radiological Sciences, China University of Science and Technology, July 2007 The polymer gel is usually composed of deionized water, a gel matrix (gel or agarose), a monomer, other additives (antioxidants, crosslinkers...). The first three items are essential raw materials, and the use of additives depends on different gel formulations and has different considerations. Deionized water is the largest proportion of the gel component (more than 80%) and serves as a source of induced free radicals. Free radicals are generated by the cleavage of water by radiation, and the radicals are polymerized with the unit body to achieve the purpose of detecting radiation. The function of the gel matrix is to convert the aqueous monomer mixture into a gel. The monomer is the protagonist of the polymer gel. Its main function is to combine the free radicals to indirectly detect the radiation. The function of the cross-linking agent is to form a water-soluble linear polymer via cross-linking to form a three-dimensionally denser and water-insoluble polymer, which can exhibit an appearance change after irradiation of radiation, so as to be quantified. Measurement. The additive also includes a substance that removes oxygen from the gel because oxygen inhibits the polymerization reaction, and even a small amount causes the gel polymerization to fail. Two methods remove oxygen from the gel dosimeter, either by flushing with nitrogen or argon while preparing the gel, and by adding an antioxidant. The former must be prepared in a low oxygen environment, and the latter is prepared under normal circumstances.

The detailed experimental procedure for preparing a gel dosimeter is disclosed in the above paper:

1. From a pure water machine, take 89 ml of deionized water in a 250 ml beaker.

2. Add 5 g of gelatin (gel matrix) at room temperature until the powder is completely dissolved and fully expanded.

3. Inject the solution into a water-blocking heating system, and then heat and stir to 45 ° C to allow gelatin to dissolve in a clear form.

4. Add 3 g of NIPAM (monomer) and 3 g of BIS (crosslinking agent) and mix evenly until all the components are completely dissolved.

5. Add 10 mM THPC (oxygen scavenger) and mix evenly until all the components are completely dissolved.

6. Dispense the gel in a test tube.

7. After the gel is dispensed, place the tube in a test tube holder covered with tin foil and let it stand at room temperature (22 ° C ~ 25 ° C) to solidify the gel.

8. The gel was prepared for radiation exposure within 6 hours.

The above process steps are performed manually by laboratory personnel. However, the key components and the accuracy of the operation time, the control of the dissolution of the raw materials and the control of the operating temperature are not easily controlled in a manual environment. More human error, which may result in different reactivity of the gel dosimeters of each test tube to radiation, affecting the accuracy and stability of the gel dosimeter. Furthermore, the gel is dispensed manually into the test tube to extend the time required for assembly. After the gel is prepared, it needs to be irradiated within 6 hours. Therefore, the gel dosimeter cannot be mass-produced by a manufacturer other than the radiotherapy unit and then sold to the medical unit. It must be personally configured by the person in the radiotherapy unit at the IMRT. The use rate is gradually increasing, and the preparation of the gel dosimeter must be more rapid. However, the manual preparation of the gel dosimeter takes a long time and the procedure is cumbersome, which undoubtedly increases the workload of the radiotherapy unit personnel, and therefore, the development of fully automated manufacturing, Filling equipment is required and will have a high application value in the medical system.

The object of the present invention is to provide a gel dosimeter automatic manufacturing and filling device which can carry out the process of preparing a gel step by step according to the set steps, and can precisely control the temperature, the stirring time and the dissolution of each raw material. To the extent that the quality of the gel dosimeter is ensured. The apparatus of the present invention can further automatically dispense the prepared gel into a test tube to achieve high timeliness of continuous and consistent manufacturing and filling operations.

The object of the present invention is to provide a system for controlling the above-mentioned manufacturing and filling equipment, which receives an operating condition set by an operator and converts the operating condition into a control signal for controlling the manufacturing and filling equipment, so that the manufacturing and filling equipment is Operating conditions to perform various operational items, through the control of the system, to achieve precise control of the entire preparation and filling process.

The object of the present invention is to provide a solution for protecting and cleaning the above-mentioned manufacturing and filling equipment, which is also automatically executed by the above-mentioned equipment and system, eliminating the problem of manual cleaning equipment, keeping the equipment clean and ensuring each manufacturing. The gel dosimeter is free of any impurities incorporated.

The present invention is a set of automated equipment and systems for preparing and loading gel dosimeters, which can replace manual manual operations, establish flexible adjustment of operating conditions as needed, and accurately control the entire operation process. The automated apparatus and system of the present invention batches all gel dosimeter processes of the same operating conditions, operates with precise repeating standards, results in a more consistent gel dosimeter, and substantially increases throughput.

The technology of the present invention for achieving the above object includes a manufacturing and filling apparatus and system, the apparatus comprising a manufacturing unit, a loading unit, a feeding unit and a cleaning unit; the manufacturing unit manufacturing a gel dosimeter, the feeding unit will be prepared The gel dosimeter is delivered to the filling unit, and the filling unit stores the gel dosimeter in a test tube for cleaning the tubing unit and the tubing of the loading unit. A system for directing, controlling, commanding, managing the manufacturing unit, loading unit, delivery unit, and cleaning unit described above, such that the units automate the steps of manufacturing and loading the gel dosimeter.

For the convenience of the description, the central idea expressed in the column of the above summary of the present invention is expressed by a specific embodiment. Various items in the embodiments are depicted in terms of ratios, dimensions, amounts of deformation, or displacements that are suitable for illustration, and are not drawn to the proportions of actual elements, as set forth above. In the following description, like elements are denoted by the same reference numerals.

As shown in the first figure and the second figure, the gel dosimeter automatic manufacturing and filling equipment of the present invention mainly comprises: a manufacturing unit 1, a loading unit 2, a feeding unit 3 and a cleaning unit 4. The manufacturing unit 1 manufactures a gel dosimeter which delivers the prepared gel dosimeter to the filling unit 2, which loads the gel dosimeter into a test tube for storage. The cleaning unit 4 is used to clean the feeding unit 3 and the piping of the loading unit 2. The above units are on a machine 9 .

The manufacturing unit 1 includes a heating agitation device 10 and a blanking device 20. In the embodiment of the present invention, the heating and stirring device 10 is an electromagnetic heating mixer, and has the functions of safe and stable heat source, temperature feedback control, and uniform stirring of the solution. The heating and agitating device 10 has a ceramic heating panel 11, a stirring speed control knob 12, a heating temperature control knob 13, and a display panel 14. A container 15 containing deionized water is placed on the ceramic heating panel 11 in a water-tight manner. The stirring speed control button 12 is used by the operator to set the stirring speed. The electromagnetic stirring operation needs to be used together with the magnetic stirring rod. The magnetic stirring rod is placed in the container 15, and the stirring driver inside the electromagnetic heating stirrer drives the magnetic stirring rod in the container. Rotate to achieve the purpose of uniformly agitating the contents of the container 15. The temperature control knob 13 is heated for the operator to set the temperature. The heating and temperature control device inside the electromagnetic heating agitator heats the solution in the vessel 15 through the ceramic heating panel 11 to a set temperature and maintains the temperature.

A temperature feedback probe (not shown) can be used in the present embodiment, which is placed in the container 15 and coupled to the heating and stirring device 10, and receives temperature and voltage changes to detect the temperature of the contents of the container 15, and The heating and agitating device 10 is fed back to control the opening and closing of the heating and agitating device 10, and the temperature of the contents in the container 15 is controlled to be between 43 and 48 ° C, but the more desirable temperature range is 44 to 47.5 ° C.

With respect to the blanking device 20 depicted in the embodiment of the present invention, it includes a plurality of trays 21 each having a function of holding a raw material and putting the raw material into the container 15. The raw material refers to a person who needs to prepare a gel dosimeter. In the embodiment of the present invention, there are four dishes, which are respectively defined as a first dish 211, a second dish 212, a third dish 213, and a fourth. Tray 214. The first vessel 211 contains a predetermined weight of a gel matrix, such as gelatin powder. The second pan 212 holds a predetermined weight of monomer, such as NIPAM powder. The third pan 213 holds a predetermined weight of a crosslinking agent such as BIS powder. The fourth vessel 214 is used to hold a predetermined weight of an additive, such as an oxygen scavenger THPC fluid. The first to third dishes 211, 212, 213 have an open box-like structure, and the inner surface of the case has a processing for preventing the powder raw material from sticking, for example, a centrifugal film having an antistatic effect on the inner surface of the case, or a nano surface. The fourth cuvette 214 is a syringe structure. The first to fourth vessels 211, 212, 213, 214 are controlled by a driver 22 to be stepwise moved along the X axis of the machine table 9 to displace one (or both) of the vessels 21 to the feed point, and to feed the material into the container 15 in. The feeding control scheme, with respect to the first to third vessels 211, 212, 213, uses a top heighter 23 to push the rear end of the vessel upward, with the front end opening facing downward, and the raw material automatically falls into the container 15. In order to completely put the powder material in the container into the container 15, a vibrator 24 is preferably used. When the rear end of the hopper is topped to touch the micro switch of the vibrator 24, the vibrator 24 vibrates the hopper, so that the powder material is completely shaken without sticking to the inner surface of the box, thereby ensuring the input The amount of raw materials is sufficient. Another feeding scheme is the fourth vessel 214 of the syringe structure, the fourth vessel 214 is fixed to an extruder 25, and when the fourth vessel 214 is moved to the feeding position, the extruder 25 is squeezed. The liquid material is injected into the container 15 by pressing. After the raw materials are added to the above-mentioned container 15 one by one, a gel dosimeter is prepared in the process in combination with heating and stirring, and the detailed steps and operating conditions are detailed later.

With regard to the loading unit 2 of the present invention, a cup holder table 30 and a filling device 40 are included. The cup holder table 30 provides a matrix arrangement of holes 31 for placement of tubes or cups of various sizes. The filling device 40 includes a charging nozzle 41 and a driver 42 that controls the movement of the charging nozzle 41 stepwise along the X-axis and the Y-axis of the machine 9.

The delivery unit 3 of the present invention includes a delivery line 51, a peristaltic pump 52, and a lifting device 53. The delivery line 51 travels through the pusher of the peristaltic pump 52, the first end of which is controlled by the lifting device 53 and can extend into or out of the container 15, the second end of the delivery line 51 Connected to the above-described filling nozzle 41.

When the preparation of the gel dosimeter is completed, the lifting device 53 controls the first end of the delivery line 51 to extend into the container 15, and the peristaltic pump 52 takes the gel dosimeter from the filling nozzle 41 by a predetermined amount. Output, the filling nozzle 41 is controlled by the driver 42 to correspond to individual vessels or cups, and a metered gel dosimeter is injected into individual vessels or cups.

The cleaning unit 4 of the present invention actually includes the heating and agitating device 10, the charging nozzle 41, the driver 42, the delivery line 51, the peristaltic pump 52, the lifting device 53, and a drainage structure 60 of the above-described loading unit. The drainage structure 60 includes a drain groove 61 and a drain line 62 connected to the drain groove 61. After the filling is completed, the other container is filled with fresh water and heated on the heating and stirring device 10 to 60 ° C. The driving device 42 drives the charging nozzle 41 corresponding to the drain groove 61, and the lifting device 53 controls the conveying line 51. The first end of the container extends into the container, and the peristaltic pump 52 continues to operate. The pumped water is discharged from the charging nozzle 41 to the drain tank 61 via the delivery line 51, and is discharged from the drain line 62. The cleaning step continues until the entire line is completely clean and free of residual gel dosimeters.

The above manufacturing and filling equipment of the invention is controlled by a system, and the process of preparing the gel and filling is controlled according to the operating conditions set by the system, as shown in the third figure, the system comprises: a central control The module 71 is configured to command, command, control, and manage the following modules; a user interface module 72 is displayed on the display panel 14 of the system, and is connected to the central control module 71 to execute a display operation interface, Receiving and displaying operational parameters, delivering operational parameters to the central management module, and displaying the current implementation of the project. The operating parameters are determined by the operator, including: components of the raw materials (eg, gelatin, NIPAM, BIS, and THPC), and the order in which the components are placed on the unloading device (eg, the first dish is Gelatin, the second dish is NIPAM, the third dish is BIS, the fourth dish is THPC), the weight of each component (g), the stirring speed and stirring time of each component, and the heating of each component during stirring Temperature, number of filling gauges for gel dosing, filling amount per tube, start/pause/terminate of preparation procedure, start/pause/terminate of filling procedure, start/pause/terminate of cleaning procedure, duration of cleaning procedure . The central control module 71 converts the control signals of the manufacturing unit 1, the loading unit 2, the feeding unit 3, and the cleaning unit 4 by using the operating parameters.

a heating and stirring control module 73, receiving the control signal of the central control module 71, controlling the heating and agitating device 10 and the temperature feedback probe, including starting/pausing/terminating, and performing the stirring speed corresponding to the operating parameter, Stirring time, and heating temperature.

The feed control module 74 receives the control signal of the central control module 71, controls the start/stop/terminate of the unloading device 20, and the movement sequence, movement time, and timing of each material.

A loading control module 75 receives the control signal of the central management module 71, controls the start/stop/terminate of the loading unit 2 and the feeding unit 3, and the single boost amount of the peristaltic pump 52, and the command driver 42 controls The filling nozzle 41 moves to correspond to the tube to be filled.

A cleaning control module 76 receives the control signal of the central control module 71, controls the start/pause/terminate of the cleaning unit 42, and commands the driver 42 to control the movement of the filling nozzle 41 to correspond to the drain tank 61 and the control heating stirring device 10. The heater heats the clean water required for cleaning to 60 ° C and controls the continuous operation time of the peristaltic pump 52 of the pumping unit 3.

As shown in the fourth figure, the process steps of the manufacturing and filling procedures of the above systems and equipment are described as follows:

In the first step, the ionized water and the raw material are prepared; the quantitative deionized water is placed in the container 15 and placed on the ceramic heating panel 11 of the heating and stirring device 10 with water. A predetermined amount of raw materials are separately prepared in each of the above-described dishes 21, for example, the first dish 211 is gelatin, the second dish 212 is NIPAM, the third dish 213 is BIS, and the fourth dish 214 is THPC.

Step 2, the first material is unloaded; the system controls the driver 22 of the unloading device 20, moves the first hopper 211 to the container 15, and commands the ejector 23 and the vibrator 24 to start, The gelatin powder in the first hopper 211 is put into the container 15.

Step 3, stirring at room temperature; the system starts the stirring driver of the heating and stirring device 10, and uniformly stirs at room temperature for 15 minutes to uniformly dissolve the gelatin in deionized water and fully expand.

Step 4, heating and stirring; the system starts the heating and temperature control device of the heating and stirring device 10, and the above deionized water and the gelatin mixture are heated and stirred at a temperature of 45 ° C for 15 minutes to make the gelatin clear.

Step 5, the second and third trays are unloaded; the system controls the driver 22 of the unloading device 20 to displace the second tray 212 and the third tray 213 respectively to the container 15, and command the top The height 23 and the vibrator 24 are activated, and the NIPAM powder and the BIS powder are separately introduced into the container 15. The heating and stirring device 10 was continuously stirred for 25 minutes at a temperature of 45 ° C until all the components were completely dissolved.

In step six, the fourth crock 214 is unloaded; the system controls the driver 22 of the unloading device 20 to displace the fourth cuvette 214 to the container 15 and command the extruder 25 to be squeezed, and the THPC is injected into the container. 15 in. The heating and stirring device 10 was continuously stirred for 2 minutes at a temperature of 45 ° C until the entire component was completely dissolved, and the preparation of the gel dosimeter was completed.

Step 7: loading; the system controls the lifting device 53, the peristaltic pump 52, and the driver 42 of the loading unit 2 to be activated, and the first end of the conveying line 51 extends into the container 15 to extract a gel dosimeter, the peristaltic pump 52 The gel dosimeter is metered to the filling unit 2 and injected into individual tubes or cups to complete the filling operation.

The inventors actually made a gel dosimeter using the mechanism and system of the present invention with components such as gelatin, NIPAM, BIS, and THPC, and presented the test report as follows.

Experiment on the dish

The three main components of Gelatin, NIPAM and BIS are each used in three dishes. Initially, the drug was placed directly on a stainless steel dish. If the drug was left in the air for a long time, it may be clotted due to moisture static electricity or other reasons. The drug could not be completely discharged when the material was cut, and the drug residue was quite serious. Therefore, the surface material of the loaded drug was improved, and four different properties of the Teflon centrifugal film were tried, and the problem of powder sticking could not be effectively overcome. Therefore, the preferred embodiment is to improve the problem of drug residue by means of vibration. The powder problem was significantly improved after using the vibrator, and the residual amount was also acceptable in the range of about 0.01 g. THPC is the last pour-in medicine, which is injected by syringe. According to the setting of the machine, it is better to put it in the machine and wait for 55 minutes between them. It may be because of the long-term disposition. The solution is to extract the THPC before the last step.

Experiment on temperature control

According to the experiments of the inventors, the heating temperature should be different depending on the volume of the gel dosimeter manufactured in the container 15, for example, the volume of 100 ml is selected to be 150 ° C, the volume of 300 ml is selected to be 170 ° C, and the volume is 600 ml. The main reason for choosing 200 °C is to consider the problem of thermal power. During the experiment, it was found that if a large volume is selected for a small temperature, such as a volume of 600 ml to select 150 ° C, the time for preheating to 45 ° C will be lengthened, which will affect the preparation time; The surface residual temperature after the heater is turned off pulls the gel dosimeter temperature too high and causes the temperature to be too high.

About the delivery and filling experiment of the gel dosimeter

During the experiment, the original setting was filled for 20 seconds to fill a 13c.c.pyrex test tube (that is, the above-mentioned tube placed in the cup holder table 30), but there was a problem in the actual measurement, so the better filling time was shortened to 18 seconds. The delivery and filling speed and time are related to the hardware conditions of the peristaltic pump. The preferred solution is to set the number of seconds required for each tube to be filled with the gel dosimeter according to the pumping speed of the peristaltic pump. Control to ensure that the amount of loading is not excessive or insufficient.

About cleaning experiments

The result of the cleaning experiment of the present invention is satisfactory in that it can be washed out before the gel is coagulated, thereby avoiding the problem that the gel solidifies and catches the tubing.

Although the present case is illustrated by a preferred embodiment, those skilled in the art can make various forms of changes without departing from the spirit and scope of the present invention. The above embodiments are only used to illustrate the present case and are not intended to limit the scope of the present invention. All kinds of modifications or changes that are not in violation of the spirit of the case are the scope of patent application in this case.

1. . . Manufacturing unit

2. . . Loading unit

3. . . Sputum unit

4. . . Cleaning unit

9. . . Machine

10. . . Heating stirrer

11. . . Ceramic heating panel

12. . . Mixing speed control button

13. . . Heating temperature control button

14. . . Display panel

15. . . container

20. . . Cutting device

twenty one. . . Petri dish

211. . . First dish

212. . . Second dish

213. . . Third dish

214. . . Fourth dish

twenty two. . . driver

twenty three. . . Top height

twenty four. . . Vibrator

25. . . Extruder

30. . . Cup holder

31. . . Hole position

40. . . Filling device

41. . . Filling mouth

42. . . driver

51. . . Delivery line 51

52. . . Peristaltic pump

53. . . Lifting device

60. . . Drainage structure

61. . . Drainage channels

62. . . Drainage line

71. . . Central control module

72. . . User interface module

73. . . Heating and stirring control module

74. . . Cutting control module

75. . . Loading control module

76. . . Cleaning control module

The first figure is a perspective view of the device of the present invention.

The second figure is a schematic diagram of the feeding of the apparatus of the present invention.

The third figure is a block diagram of the system of the present invention.

The fourth figure is a flow chart of the present invention.

1. . . Manufacturing unit

2. . . Loading unit

3. . . Sputum unit

4. . . Cleaning unit

9. . . Machine

10. . . Heating stirrer

11. . . Ceramic heating panel

12. . . Mixing speed control button

13. . . Heating temperature control button

14. . . Display panel

15. . . container

20. . . Cutting device

twenty one. . . Feeder

211. . . First feeder

212. . . Second feeder

213. . . Third feeder

214. . . Fourth feeder

twenty two. . . driver

twenty three. . . Top height

twenty four. . . Vibrator

25. . . Extruder

30. . . Cup holder

31. . . Hole position

40. . . Filling device

41. . . Filling mouth

42. . . driver

51. . . Delivery line 51

52. . . Peristaltic pump

53. . . Lifting device

60. . . Drainage structure

61. . . Drainage channels

62. . . Drainage line

Claims (2)

The invention relates to a manufacturing process of a gel dosimeter automatic manufacturing and filling device and a step of filling a gel dosimeter, the device comprising: a manufacturing unit, a feeding unit, a filling unit, and a drainage structure; the manufacturing unit comprises a heating and stirring a device and a feeding device, a container is placed on the heating agitating device; the unloading device comprises a first vessel, a second vessel, a third vessel, and a fourth vessel respectively containing raw materials for manufacturing the gel dosimeter And driving the plurality of trays to be stepped to a feeding point for feeding; the feeding unit comprises a conveying line passing through a peristaltic pump, the first end of the conveying line is connected to the container, The second end of the conveying pipe is connected to a filling nozzle; the filling unit comprises a cup holder table for each size of the tube or the cup, and a connecting and controlling the filling nozzle along the cup holder table X a shaft and a Y-axis step-moving drive; the raw material for manufacturing the gel dosimeter includes deionized water, a gel matrix, a monomer, a crosslinking agent, and an oxygen scavenger, wherein the deionized water is placed in the container in, The container is placed on the heating agitator with water, the gel matrix is placed in the first vessel, the monomer is placed in the second vessel, and the crosslinking agent is placed in the third vessel, An oxygen scavenger is placed in the fourth vessel; the apparatus is subjected to a manufacturing and loading gel dosimeter by a system of command, control, and command, the step comprising: step one, the system controls the blanking Actuating a device for moving the first vessel to the feed point, the gel matrix being placed in the deionized water of the container; Step two, the system starts the heating and stirring device to stir the deionized water in the container and the gel matrix for 15 minutes at room temperature, so that the gel matrix is uniformly dissolved in deionized water and fully expanded; and step three, the The system starts the heating and stirring device, and the above-mentioned deionized water and gel matrix mixture is heated and stirred at a temperature of 45 ° C for 15 minutes to make the mixture clear; and in step 4, the system controls the driving device of the blanking device, so that Disposing the second material vessel and the third material tank to the feeding point respectively, and respectively inputting the monomer and the crosslinking agent into the mixture of the third step; the system controls the heating stirring device to continuously stir for 25 minutes, and the temperature is 45 ° C. And step 5, the system controls the driver of the unloading device, the fourth vessel is displaced to the feeding point, and the oxygen scavenger is put into the mixture of the fourth step; the system controls the heating stirring device to continue stirring for 2 minutes. At 45 ° C, the preparation of the gel dosimeter is completed; and in step 6, the system activates the feeding unit and the filling unit, and the gel dosimeter in the container is driven by the peristaltic pump Quantitatively passing the delivery line to the filling nozzle, the driver of the loading unit controls the filling nozzle to inject a gel dosimeter into the tube or the cup. The step of claim 1, further comprising the step of: a washing step, comprising: taking another container to hold the fresh water and heating the mixture to 60 ° C, the system commands the filling device a drive is activated, the filling nozzle corresponds to the drainage structure, the system commands the peristaltic pump to start, and the clean water in the container is output to the drainage structure via the delivery line and the filling nozzle; the cleaning step is repeated It is carried out until the delivery line and the filling nozzle have no residual gel dosimeter.