TWI441621B - Device for detecting the time of micturating by using the bioimpedance technique and the method thereof - Google Patents

Description

Method and device for detecting timing of bladder urination by bioimpedance technology

The invention relates to a bioimpedance detection method and a device thereof, in particular to a method and a device for detecting the timing of bladder urination.

According to the general urinary dysfunction patients, such as stroke, spinal injury, pelvic surgery, diabetes and neurogenic bladder dysfunction or prostate enlargement, due to spinal nerve damage or abnormal bladder function Urinary sensation, which makes it impossible to judge the timing of urination by itself, must be urinary through several times a day to solve the problem of urination.

In the past, the timing of urinating patients can only rely on the experience of medical staff to conduct trial and error, but each patient's urine metabolism time is not the same. When using the same standard for all patients, it often increases the redundantness of some patients. Moreover, the number of catheterizations is not necessary, and the risk of urinary tract infection caused by catheterization is increased, and the physical and psychological damage of the patient and the burden on the caregiver are also caused.

In order to solve the problem of urine monitoring of the above patients, the inventor proposed a bladder urine volume sensor based on ultrasonic sensing technology (Japanese Patent No. 105737, 2004), which is based on ultrasonic sound wave reflection time. And the state of attenuation, to measure the amount of urine in the bladder to determine whether it is the catheterization time of the patient, although it can greatly improve the urine monitoring and urinary tract infection, care of human resources and other issues, but Ultrasonic bladder urine volume sensor requires professional personnel to interpret its sensing results, and it is not easy to carry and expensive, and it is only suitable for large hospitals, and it is difficult to extend to personal home care environment.

In addition, for patients with dysuria, the proper timing of urination depends on the amount of urine in the bladder, and the principle of bioimpedance established by Hoffer and Nyboer et al. is attached by four electrodes. The local tissue of the human body causes a current to pass through the local tissue to generate a voltage difference to obtain the impedance value of the local tissue, so that the tissue state of the part, such as body water, body fat, lean meat, etc., can be known through the impedance change; The impedance value is inversely related to the conductivity value. When the impedance value measured by the local tissue of the human body is smaller, the conductivity value is relatively larger, indicating that the local tissue has better conductivity and more water content, thereby the invention of the present invention. It is envisaged to propose a method and device for detecting bladder urine volume based on bioimpedance technology.

In view of the above-mentioned conventional method for measuring the amount of bladder urine and the use of the device, the inventor of the present invention, with his years of experience in research and development of related products and technologies, believes that it is necessary to develop a method for detecting the timing of bladder urination by bioimpedance technology. And its equipment.

The main object of the present invention is to provide a method for detecting bladder urination time by bioimpedance technology and a device thereof, which mainly measure a bladder urine volume of a subject by a non-invasive detection method combined with a bladder urine amount detecting device. The detection method steps include: emptying the bladder of the subject, establishing a basic conductance value, establishing a standard urinary conductance value, detecting a urine volume, and informing a timing of urinating; the amount of urine prior to the bladder urine amount detecting device In the evaluation unit, the basic conductance value of the individual in the bladder emptying state and the standard urinary conductance value corresponding to the bladder effective storage urine volume are established, and then the conductance measurement of the device is repeated after the interval of one physiological metabolic time. The unit is set on the skin on both sides of the bladder position of the subject, and the bioimpedance technique is used to measure the change of the bladder urine volume and the corresponding conductance value of the test subject. The bladder urine volume of the test subject is greater than the bladder effective storage urine volume. When the obtained measured conductance value is greater than the urinary standard conductance value, the device notifies that the subject has reached the urination timing.

Another object of the present invention is to provide a bladder urine volume detecting device based on bioimpedance technology, which mainly comprises a central processing unit, a conductance measuring unit and a urine amount evaluating unit, wherein the conductance measuring unit is Having two opposite electrodes attached to the bladder surface of the subject, and a detection electrode is attached between each of the introduction electrodes and the bladder; the urine amount evaluation unit has an evaluation model, The evaluation model is pre-set with a standard urinary conductance value corresponding to the bladder volume of the bladder in which the subject is effectively stored, and the conductance measuring unit measures the amount of bladder urine of the subject to form a measured conductance value to be output to the evaluation model. To determine whether the subject's bladder urine volume reaches the bladder's effective storage urine volume.

Therefore, the non-invasive method for detecting the amount of bladder urine provided by the invention can not only effectively avoid the risk of urinary tract infection caused by catheterization, but also achieve the purpose of maintaining patient dignity and reducing labor expenditure, due to the detection of the present invention. The method is based on the comparison of the conductance of the individual in the bladder and the effective urine volume of the bladder, and has a more accurate positive correlation with the change of the conventional urine volume and the change of the conductance value; The detection method and device of the invention are easy to operate and use, and can be applied to the home care center of a non-medical system or a general community in the general community without the judgment of a professional, and for a patient and a medical system that need to monitor the urine state for a long time. In other words, patients can get urine monitoring at home, and in addition to reducing the hospitalization expenses of patients, they can also transfer medical resources to patients who need it more.

In order to enable the reviewing committee to have a better understanding and understanding of the purpose, features and effects of the present invention, please refer to the following [detailed description of the drawings] as follows: First, please refer to FIG. 1 to show the present invention. The present invention provides a preferred embodiment of a bladder urine volume detecting device for detecting a human bladder urinary timing by a bioimpedance technique, which mainly includes a central processing unit 10, a conductance measuring unit 20, and a urine amount evaluating unit 30, wherein The central processing unit 10 is electrically connected to a power source 11 , an output device 12 , and an input device 13 . The conductance measuring unit 20 is electrically connected to the central processing unit 10 and has two detecting electrodes 21 and The second introduction electrode 22 is attached to the opposite side skin of the bladder X position of the subject, and the detection electrode 21 is attached between each of the introduction electrode 22 and the bladder X; The urine amount evaluation unit 30 is electrically connected to the central processing unit 10 and has an evaluation model 31 pre-set with a standard urinary conductance value 311 corresponding to the bladder effective storage urine volume of the subject. The conductance measuring unit 20 measures the amount of bladder X urine of the subject to form a measured conductance value and outputs the measured value to the evaluation model 31 to determine whether the bladder urine of the subject reaches the bladder to effectively store urine. In the present embodiment, the urine amount evaluation unit 30 is further provided with a timer 32 for calculating the bio-metabolization time of the subject and the career measurement interval time; and the power source 11 is a battery power source or An AC battery, the output device 12 is a display, and the input device 13 is a keyboard or a button or a touch screen.

The above description is the main components of the embodiment of the present invention and the configuration description thereof. As for the detection method and the efficacy of the preferred embodiment of the bladder urine detecting device for detecting the timing of bladder urination by the bioimpedance technique, the following description will be made.

Please refer to the figures 2 and 3, the method for detecting bladder urination time by bioimpedance technology, the method steps mainly include a bladder emptying of a subject, establishing a basic conductance value b, establishing a standard urinary conductance value c Detecting the amount of urine d, the timing of urinary excretion of the subject; wherein: the bladder emptying of the subject a: causing a subject to empty the urine in the bladder; establishing a basic conductance value b: a bladder urine amount One conductivity measuring unit 20 of the detecting device is disposed on the surface skin of the subject on both sides of the X position of the bladder to measure the conductance value of the bladder when the subject is empty, and a basic conductance value is stored and stored in the bladder urine. In the present embodiment, as shown in FIG. 1, the conductance measuring unit 20 has the two lead-in electrodes 22 and the two detecting electrodes 21, which The second introduction electrode 22 is attached to the skin on the opposite sides of the bladder X position of the subject, and a detection electrode 21 is attached between each of the introduction electrodes 22 and the bladder X; in addition, the subject Before attaching the detecting electrode 21 and the introducing electrode 22, Wiping the surface skin of the bladder position with medicinal alcohol; establishing a standard urinary conductance value c: storing a bladder effective storage urine volume in the bladder urine amount detecting device, and calculating the urine amount estimating unit 30 The urinary standard conductance value 311 is stored in the urine amount evaluation unit 30 as a standard reference value; in the embodiment, the bladder effective storage urine volume is an effective storage volume of urine in the bladder of the subject. Or use the bladder volume of the bladder in the clinical literature to store 400 ml of urine as the standard value for establishing the standard value of urinary discharge; and to detect the amount of urine d: after the interval of physiological metabolism, the conductance measuring unit 20 is set in the subject. The surface skin located on both sides of the X position of the bladder, measuring the change in the conductance value of the bladder urine amount of the subject as the physiological metabolic time increases, and the output of the measured conductance value is stored in the urine amount evaluation unit 30; Urination timing e: Repeat the previous step d to detect the urine volume of the subject. When the measured conductance value measured by the subject is greater than the standard urinary conductance value 311, the bladder urine volume is loaded. One central processing unit 10 outputs a warning signal to inform the subject that the amount of bladder urine has reached the bladder effective storage urine volume, and is the urinary timing of the subject; wherein, further illustrating the bioimpedance of the present invention The biological circuit model to be tested in the method for detecting the timing of bladder urination, as shown in FIG. 4, in the step b of establishing the basic conductance value and the step c of establishing the standard urinary conductance value, the bladder urine amount detecting device The conductance value (G) obtained by measuring the X portion of the human bladder is defined as i (ω) / v (ω), and the biological circuit model to be tested is from the outside to the inside, and the skin A and the subcutaneous tissue B and muscle above the bladder X. The soft tissue such as layer C and the bladder X body and its internal urine are composed in parallel, and have the following road model:

G=G ₁ +G ₂ (1)

Wherein G represents the total conductance value, G ₁ represents the conductance value of skin A and soft tissue B, C, G ₂ represents the conductance value of bladder X and its internal urine; and, the conductance value (G) is the reciprocal of the impedance value, G=1/ I _m , so equation (1) can represent the impedance value as in equation (2):

Please refer to FIG. 5 to show the detection method based on the above circuit model and the bladder urine amount detecting device of the present invention, and measure the urine volume of the bladder to be 0 ml, 200 ml, 400 ml, 600 ml, 800 ml. The corresponding conductance value (G), as shown in Fig. 5, shows that the relationship between the conductance value (G) and the amount of bladder urine has a positive relationship, and has a correlation coefficient (r) of about 0.84.

In addition, as shown in FIG. 6 , the measured conductance value of the bladder urine amount (ie, the measured conductance value described in the detection method of the present invention) is subtracted from the post-bladder emptying conductance value (ie, the detection method of the present invention) The relationship diagram obtained from the basic conductance value is shown in Fig. 6. It is known that there is a positive relationship between the amount of change in urine volume (ΔV) and the amount of change in conductance value (ΔG), and the correlation coefficient (r) is about 0.98.

Thereby, after the regression analysis, the present invention can obtain a prediction formula of the change amount of the conductance value (ΔG) to the volume change of the urine volume (ΔV), that is, the evaluation model described in the detection method of the present invention: the change amount of the conductance value ( ΔG) is the strain number y (1/ohm), and the volume change of urine volume (ΔV) is the self-variable x (ml). The prediction formula can be obtained by regression analysis as follows:

y=0.000002*x

In summary, the present invention measures the basic conductance value and the urinary standard conductance value of the individual subject through the easy-to-operate sensing principle, and establishes a judgment criterion for judging the urinary timing of the individual subject, and then the subject's urinary timing criterion. The change of the measured conductance value during the urine metabolism time determines the appropriate urinary timing of the subject to avoid unnecessary catheterization times, to maintain the patient's dignity and reduce the burden on the caregiver, and to provide an easy operation timing for urinating. Method and device for detecting bladder urine volume.

a. . . Subject's bladder emptying

b. . . Establish basic conductance values

c. . . Establish a standard urinary conductance value

d. . . Detecting urine volume

e. . . Notification of urinary timing

10. . . CPU

11. . . power supply

12. . . Output device

13. . . Input device

20. . . Conductivity measuring unit

twenty one. . . Detection electrode

twenty two. . . Lead electrode

30. . . Urine volume evaluation unit

31. . . Evaluation model

311. . . Urinary standard conductance value

32. . . Timer

A. . . epidermis

B. . . Subcutaneous tissue

C. . . muscle

X. . . bladder

V. . . Voltmeter

r. . . Correlation coefficient

Fig. 1 is a schematic view showing the structure of a bladder urine amount detecting device of the present invention.

Fig. 2 is a schematic flow chart showing the steps of the method for detecting the timing of bladder urination by bioimpedance technique.

Fig. 3 is a schematic diagram showing the flow of the method for detecting the timing of bladder urination by bioimpedance technique.

Fig. 4 is a schematic view showing a biological circuit model for measuring a bladder portion of a human body by the bladder urine amount detecting device of the present invention.

Fig. 5 is a graph showing the relationship between the amount of bladder urine (ml) and the conductance value (G) of the present invention.

Fig. 6 is a graph showing the relationship between the amount of change in the volume of bladder urine (?V) and the amount of change in conductance (?G) of the present invention.

a. . . Subject's bladder emptying

b. . . Establish basic conductance values

c. . . Establish a standard urinary conductance value

d. . . Detecting urine volume

e. . . Notification of urinary timing

Claims (7)

A method for detecting the timing of bladder urination by bioimpedance technology, wherein the method of the detection method comprises: emptying the bladder of the subject, causing a subject to empty the urine in the bladder; establishing a basic conductance value, A conductance measuring unit of the bladder urine volume detecting device is disposed on the surface skin of the subject on both sides of the bladder position to measure the conductance value of the subject during bladder emptying, and a basic conductance value is stored in the bladder. A urine amount evaluation unit of the urine amount detecting device; establishing a standard urinary conductance value, and inputting a bladder effective storage urine volume into the bladder urine amount detecting device, and calculating a urine output by the urine amount evaluating unit The standard conductance value; wherein the urine amount evaluation unit obtains an evaluation model of the change amount of the conductance value to the volume change of the urine volume through regression analysis, which is expressed as: y=0.000002*x, Note: the change amount of the conductance value ( △G) is the strain number y (1/ohm), the volume change of urine volume (ΔV) is the self-variable x (ml); the amount of urine is detected after the interval-physiological metabolic time, the conductance measurement unit is set For the subject The surface skin on both sides of the bladder position measures the change in the conductance value of the bladder urine amount of the subject as the physiological metabolic time increases, and the measured conductance value is stored in the urine volume evaluation unit; the timing of the urination is notified. , repeatedly detecting the amount of urine of the subject, waiting for the subject When the measured conductance value measured by the tester is greater than the urinary standard conductance value, the bladder urine volume detecting device informs the subject that the bladder urine volume has reached the bladder effective storage urine volume, and is the measured The timing of urinating. The method for detecting a timing of bladder urination by a bioimpedance technique according to the first aspect of the patent application, wherein the conductance measuring unit of the bladder urine amount detecting device has two lead electrodes and two detecting electrodes; In the conductance value establishing step, the two lead-in electrodes are attached to the skin on the opposite sides of the bladder position of the subject, and a detecting electrode is attached between each of the lead-in electrodes and the bladder. A method for detecting a timing of bladder urination by a bioimpedance technique as described in claim 1, wherein the step of establishing a basic conductance value and the step of establishing a standard urinary conductance value are performed by a skin, soft tissue, and bladder above the bladder and The internal urine is composed of parallel, and its total conductance is expressed as: G=G ₁ +G ₂ where G is the total conductance value, G ₁ is the conductance value of skin and soft tissue, and G ₂ is the bladder and its internal The conductance value of urine. The method for detecting the timing of bladder urination by the bioimpedance technique according to the first aspect of the patent application, wherein the bladder effective storage urine volume described in the urinary standard conductance value establishing step is 400 ml. A bladder urine volume detecting device for detecting a urinary timing of a human bladder by a bioimpedance technique, wherein the device comprises: a central processing unit electrically connected to a power source, an output device and a The input device; the conductivity measuring unit is electrically connected to the central processing unit, and has two detecting electrodes and two lead electrodes, and the two introducing electrodes are attached to the opposite side skins of the bladder position of the subject And a detecting electrode is attached between each of the introducing electrodes and the bladder; a urine amount evaluating unit is electrically connected to the central processing unit, and has an evaluation model, and the evaluation model is pre-configured The test subject effectively stores one of the urine volume standard urinary conductance values, so that the conductance measuring unit measures the bladder urine volume of the test subject to form a measured conductance value and outputs the measured conductance value to the evaluation model to determine the subject Whether the amount of bladder urine reaches the volume of urine stored in the bladder; wherein the urine volume evaluation unit obtains an evaluation model of the change amount of the urine volume by regression analysis, which is expressed as: y= 0.000002*x, Note: The change in conductance value (ΔG) is the strain number y (1/ohm), and the change in urine volume (ΔV) is the self-variable x (ml). The bladder urine volume detecting device according to claim 5, wherein the power source is a battery power source or an alternating current battery; the output device is a display; and the input device is a keyboard or a button or a touch screen. The bladder urine volume detecting device according to claim 5, wherein the urine amount evaluating unit is electrically connected to a timer.